MCID: TRP004
MIFTS: 38

Tropical Sprue

Categories: Rare diseases, Gastrointestinal diseases

Aliases & Classifications for Tropical Sprue

MalaCards integrated aliases for Tropical Sprue:

Name: Tropical Sprue 12 72 49 14
Sprue, Tropical 41 69
Idiopathic Tropical Malabsorption Syndrome 49
Tropical Steatorrhea 12
Tropical Enteropathy 49
Sprue - Tropical 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10607
ICD10 32 K90.1
ICD9CM 34 579.1
MeSH 41 D013182
NCIt 46 C45428
UMLS 69 C0038054

Summaries for Tropical Sprue

MalaCards based summary : Tropical Sprue, also known as sprue, tropical, is related to whipple disease and celiac disease 1. An important gene associated with Tropical Sprue is GGH (Gamma-Glutamyl Hydrolase), and among its related pathways/superpathways are Selenium Micronutrient Network and FOXA2 and FOXA3 transcription factor networks. The drugs Glycine and Vaccines have been mentioned in the context of this disorder. Affiliated tissues include small intestine, testes and pancreas, and related phenotype is liver/biliary system.

Wikipedia : 72 Tropical sprue is a malabsorption disease commonly found in tropical regions, marked with abnormal... more...

Related Diseases for Tropical Sprue

Diseases related to Tropical Sprue via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 32)
# Related Disease Score Top Affiliating Genes
1 whipple disease 11.3
2 celiac disease 1 10.2
3 steatorrhea 10.1
4 diarrhea 10.1
5 blood group, i system 10.0
6 macrocytic anemia 10.0
7 pernicious anemia 10.0
8 blind loop syndrome 10.0
9 megaloblastic anemia 10.0
10 gastroenteritis 10.0
11 pancreatitis 10.0
12 pneumonia 10.0
13 intussusception 9.8
14 hypokalemic periodic paralysis, type 1 9.8
15 myeloma, multiple 9.8
16 aging 9.8
17 malaria 9.8
18 hydrops, lactic acidosis, and sideroblastic anemia 9.8
19 exocrine pancreatic insufficiency 9.8
20 hepatitis 9.8
21 thrombocytopenia 9.8
22 vitamin b12 deficiency 9.8
23 colitis 9.8
24 microscopic colitis 9.8
25 mucositis 9.8
26 megacolon 9.8
27 dysentery 9.8
28 agammaglobulinemia 9.8
29 duodenitis 9.8
30 galactosemia 9.7 ALDOB GIF
31 small intestine lymphoma 9.3 ALDOB CD3E GIF
32 nutritional deficiency disease 9.3 ALB GIF

Comorbidity relations with Tropical Sprue via Phenotypic Disease Network (PDN):


Celiac Disease 1 Deficiency Anemia
Protein-Energy Malnutrition

Graphical network of the top 20 diseases related to Tropical Sprue:



Diseases related to Tropical Sprue

Symptoms & Phenotypes for Tropical Sprue

MGI Mouse Phenotypes related to Tropical Sprue:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 liver/biliary system MP:0005370 8.8 ALB ALDOB GIF

Drugs & Therapeutics for Tropical Sprue

Drugs for Tropical Sprue (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Glycine Approved, Nutraceutical, Vet_approved Phase 3 56-40-6 750
2 Vaccines Phase 3,Phase 1
3 Neurotransmitter Agents Phase 3
4 glutamine Nutraceutical Phase 3
5 Analgesics Phase 1, Phase 2
6 Analgesics, Non-Narcotic Phase 1, Phase 2
7 Anti-Inflammatory Agents Phase 1, Phase 2
8 Anti-Inflammatory Agents, Non-Steroidal Phase 1, Phase 2
9 Antirheumatic Agents Phase 1, Phase 2
10 Mesalamine Phase 1, Phase 2 89-57-6
11 Peripheral Nervous System Agents Phase 1, Phase 2
12
Rifaximin Approved, Investigational 80621-81-4 6436173
13
Vitamin A Approved, Nutraceutical, Vet_approved 68-26-8, 11103-57-4 445354
14 Anti-Bacterial Agents
15 Antibiotics, Antitubercular
16 Anti-Infective Agents
17 Gastrointestinal Agents
18 Nucleic Acid Synthesis Inhibitors
19 rifamycin SV
20 Rifamycins
21 Antibodies
22 Immunoglobulins
23 Micronutrients
24 Retinol palmitate
25 Trace Elements
26 Vitamins
27 Disinfectants
28 retinol Nutraceutical

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Exploration of the Biologic Basis for Underperformance of Oral Polio and Rotavirus Vaccines in Bangladesh Completed NCT01375647 Phase 3
2 Intervention and Mechanisms of Alanyl-Glutamine for Inflammation, Nutrition, and Enteropathy Completed NCT01832636 Phase 3
3 Mesalamine in Environmental Enteropathy Completed NCT01841099 Phase 1, Phase 2 Mesalamine;Placebo granules
4 Exploration of the Biologic Basis for Underperformance of Oral Polio and Rotavirus Vaccines in INDIA (PROVIDE) Completed NCT01571505 Phase 1
5 Trial of Rifaximin in the Treatment of Tropical Enteropathy Completed NCT00858988 Rifaximin
6 Plasma Citrulline Concentration in Tropical Enteropathy Completed NCT00816842
7 WASH Benefits Kenya Completed NCT01704105
8 Effectiveness of Point-of-use Water Treatment Technologies to Prevent Stunting Among Children in South Africa Active, not recruiting NCT03012048
9 WASH Benefits Bangladesh Active, not recruiting NCT01590095

Search NIH Clinical Center for Tropical Sprue

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: sprue, tropical

Genetic Tests for Tropical Sprue

Anatomical Context for Tropical Sprue

MalaCards organs/tissues related to Tropical Sprue:

38
Small Intestine, Testes, Pancreas, Liver, Colon, Adrenal Gland, Whole Blood

Publications for Tropical Sprue

Articles related to Tropical Sprue:

(show top 50) (show all 356)
# Title Authors Year
1
Post-infectious IBS, tropical sprue and small intestinal bacterial overgrowth: the missing link. ( 28513629 )
2017
2
Infectious Gastroenteritis as a Risk Factor for Tropical Sprue and Malabsorption: A Case-Control Study. ( 26115751 )
2015
3
Distinguishing tropical sprue from celiac disease in returning travellers with chronic diarrhoea: a diagnostic challenge? ( 24889052 )
2014
4
Tropical sprue in 2014: the new face of an old disease. ( 24781741 )
2014
5
Tropical sprue: revisiting an underrecognized disease. ( 24441659 )
2014
6
Pathogenesis of tropical sprue: a pilot study of antroduodenal manometry, duodenocaecal transit time & fat-induced ileal brake. ( 23481053 )
2013
7
A presentation of latent tropical sprue in a Canadian hospital. ( 23636074 )
2013
8
Tropical sprue: a riddle wrapped in a mystery inside an enigma. ( 23481048 )
2013
9
Tropical sprue: two cases report and review of literature. Has anything changed in the past 40 years? ( 23590053 )
2013
10
Is the ghost of tropical sprue re-surfacing after its obituary? ( 22315742 )
2011
11
Spectrum of malabsorption in India--tropical sprue is still the leader. ( 22315745 )
2011
12
Abnormal small intestinal permeability in patients with idiopathic malabsorption in tropics (tropical sprue) does not change even after successful treatment. ( 20411417 )
2011
13
The Face of Tropical Sprue in 2010. ( 20805939 )
2010
14
Classification of villous atrophy with enhanced magnification endoscopy in patients with celiac disease and tropical sprue. ( 17643717 )
2007
15
Tropical sprue in two foreign residents, with evidence of Tropheryma whippelii in one case. ( 16706950 )
2006
16
Tropical sprue in Far North Queensland. ( 15896184 )
2005
17
Tropical sprue. ( 16168231 )
2005
18
Tropical Sprue. ( 14723833 )
2004
19
Tropical sprue: revisited. ( 15129872 )
2004
20
Images of interest. Gastrointestinal: tropical sprue. ( 15304129 )
2004
21
Tropical sprue is associated with contamination of small bowel with aerobic bacteria and reversible prolongation of orocecal transit time. ( 12702046 )
2003
22
What is tropical sprue? ( 12859716 )
2003
23
Exocrine pancreatic insufficiency in tropical sprue. ( 11173897 )
2001
24
A perspective on tropical sprue. ( 11470001 )
2001
25
Treatment of tropical sprue: the work of Dr. Bailey K. Ashford examined in retrospect. ( 11776723 )
2001
26
Tropical sprue in north Indian children. ( 11681110 )
2001
27
Tropical sprue as a cause of traveler's diarrhea. ( 10921367 )
2000
28
Tropical sprue after travel to Tanzania. ( 10689238 )
2000
29
Tropical sprue and subclinical enteropathy: a vision for the nineties. ( 9288443 )
1997
30
Hypokalemic periodic paralysis in association with tropical sprue: a case report. ( 7887139 )
1994
31
Association of lymphocytic (microscopic) colitis with tropical sprue. ( 8155860 )
1994
32
Case records of the Massachusetts General Hospital weekly clinicopathological exercises. Case 29-1992. A 76-year-old woman with recurrent diarrhea several months after treatment for tropical sprue. ( 1608409 )
1992
33
Quantitation of immunoglobulin-containing cells in the jejunal lamina propria in tropical sprue. ( 1556433 )
1992
34
Scalloping of the valvulae conniventes and mosaic mucosa in tropical sprue. ( 2070991 )
1991
35
Tropical sprue. ( 2205942 )
1990
36
Vincent Ketelaer did not describe tropical or non-tropical sprue or coeliac disease in his book De Aphthis Nostratibus seu Belgarum Sprouw. ( 2278120 )
1990
37
Intestinal transit in healthy southern Indian subjects and in patients with tropical sprue. ( 2920924 )
1989
38
Jejunal surface pH measurements in tropical sprue. ( 2603196 )
1989
39
Absorption of water and sodium and activity of adenosine triphosphatases in the rectal mucosa in tropical sprue. ( 2840363 )
1988
40
Tropical sprue in southern India. ( 3051540 )
1988
41
Role of bacterial toxins, bile acids, and free fatty acids in colonic water malabsorption in tropical sprue. ( 3568936 )
1987
42
Tropical sprue and multiple myeloma. ( 3462885 )
1986
43
Epithelial cell renewal and turnover and relationship to morphologic abnormalities in jejunal mucosa in tropical sprue. ( 3709324 )
1986
44
Tropical sprue--a clinical, biochemical and histopathological study. ( 3564147 )
1986
45
Intestinal absorption and unmediated permeation of sugars in post-infective tropical malabsorption (tropical sprue). ( 3949090 )
1986
46
Tropical sprue--its aetiology and pathogenesis. ( 3537290 )
1986
47
HLA and tropical sprue. ( 2877326 )
1986
48
Tropical sprue in visitor to Mexico. ( 2857825 )
1985
49
Aetiology and pathogenesis of tropical sprue: do viruses play a role? ( 4024249 )
1985
50
Functional and structural aspects of the epithelial lymphocyte, with implications for coeliac disease and tropical sprue. ( 2935927 )
1985

Variations for Tropical Sprue

Expression for Tropical Sprue

Search GEO for disease gene expression data for Tropical Sprue.

Pathways for Tropical Sprue

Pathways related to Tropical Sprue according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.29 ALB GIF
2 10.27 ALB ALDOB

GO Terms for Tropical Sprue

Sources for Tropical Sprue

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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