MCID: TRY001
MIFTS: 49

Trypanosomiasis malady

Infectious diseases category
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Summaries for Trypanosomiasis

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8Disease Ontology, 65Wikipedia, 33MalaCards
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Disease Ontology:8 A parasitic protozoa infectious disease that involves infection caused by parasitic protozoan of the genus trypanosoma in animals and humans.

MalaCards: Trypanosomiasis is related to sleeping sickness and chagas disease. An important gene associated with Trypanosomiasis is APOL1 (apolipoprotein L, 1), and among its related pathways are Cholesterol and Sphingolipids transport Recycling to plasma membrane in lung normal and CF and Primary immunodeficiency. The drugs pentamidine and pentamidine isethionate and the compounds 1-aminooxy-3-aminopropane and selenocystine have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and t cells.

Wikipedia:65 Trypanosomiasis or trypanosomosis is the name of several diseases in vertebrates caused by parasitic... more...

Aliases & Classifications for Trypanosomiasis

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8Disease Ontology, 45Novoseek, 62UMLS, 58SNOMED-CT, 27ICD9CM, 35MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Aliases & Descriptions:

trypanosomiasis 8 45 62


External Ids:

Disease Ontology8 DOID:10113
ICD9CM27 086, 086.9
MeSH35 D014352

Related Diseases for Trypanosomiasis

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17GeneCards, 18GeneDecks
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Diseases related to Trypanosomiasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 52)
idRelated DiseaseScoreTop Affiliating Genes
1sleeping sickness31.2ODC1, APOL1, SRM, HPR
2chagas disease31.2ODC1, SRM, GSR
3leishmaniasis31.0PGD, SRM
4malaria30.8GSR, HPR, SRM, ODC1
5amebiasis10.2
6cerebritis10.2
7encephalitis10.2
8trypanosomiasis, human east-african10.2
9babesiosis10.1
10trichinosis10.1
11louping ill10.1
12schistosomiasis10.1
13toxoplasmosis10.1
14trypanosomiasis, human west-african10.1
15glucosephosphate dehydrogenase deficiency10.1GSR, HPR
16gastric ulcer10.1GSR, ODC1
17beta thalassemia10.1GSR, TF
18primary hyperoxaluria10.1HPR, APOL1, APOA1
19hepatitis10.0TF, TXN, GSR
20adult respiratory distress syndrome10.0TXN, TF
21fatty liver disease10.0TF, TXN, APOA1
22hepatitis c10.0GSR, TXN, TF
23congenital heart disease10.0TXN, APOA1, GSR
24acute myocardial infarction10.0GSR, APOA1, TXN
25b-cell lymphomas10.0TNFRSF13C, TXN, SRM
26schizophrenia10.0ODC1, APOL1, PREP, GSR
27hepatitis b10.0GSR, APOA1, TXN
28vascular disease10.0GSR, HPR, TXN, TF
29deficiency anemia10.0TF, TXN, PGD, HPR, GSR
30chronic kidney failure10.0GSR, APOA1, TF
31diabetes mellitus10.0GSR, HPR, APOA1, TXN, TF
32c1q deficiency10.0C1QA, C1QC, C1QB
33malignant glioma10.0ODC1, PREP, CCL3L1, GSR
34trichomoniasis9.9
35orchitis9.9
36endomyocardial fibrosis9.9
37eastern equine encephalitis9.9
38onchocerciasis9.9
39pseudobulbar palsy9.9
40loiasis9.9
41cutaneous leishmaniasis9.9
42lymphocytic choriomeningitis9.9
43filariasis9.9
44microsporidiosis9.9
45myocarditis9.9
46relapsing fever9.9
47tuberculosis9.9
48yaws9.9
49helminthiasis9.9
50hiv-19.9

Graphical network of the top 20 diseases related to Trypanosomiasis:



Diseases related to trypanosomiasis

Symptoms for Trypanosomiasis

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Drugs & Therapeutics for Trypanosomiasis

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Trypanosomiasis

Search NIH Clinical Center for Trypanosomiasis

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Trypanosomiasis

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Anatomical Context for Trypanosomiasis

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33MalaCards
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MalaCards organs/tissues related to Trypanosomiasis:

33
Testes, Brain, T cells, Heart, Skin, Myeloid, B cells, Endothelial

Animal Models for Trypanosomiasis or affiliated genes

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Publications for Trypanosomiasis

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Sources:
52PubMed
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Articles related to Trypanosomiasis:

(show top 50)    (show all 523)
idTitleAuthorsYear
1
Social factors affecting seasonal variation in bovine trypanosomiasis on the Jos Plateau, Nigeria. (24172046)
2013
2
HLA-G 3' UTR-2 haplotype is associated with Human African trypanosomiasis susceptibility. (23541412)
2013
3
An exploratory GIS-based method to identify and characterise landscapes with an elevated epidemiological risk of Rhodesian human African trypanosomiasis. (23171150)
2012
4
Modeling the control of trypanosomiasis using trypanocides or insecticide-treated livestock. (22616017)
2012
5
Human African trypanosomiasis in South Sudan: how can we prevent a new epidemic? (22666506)
2012
6
Trypanosomiasis in an infant from India. (21715739)
2011
7
Transmission of human African trypanosomiasis in the Komo-Mondah focus, Gabon. (22121444)
2011
8
Dental management of the tropical disease human African trypanosomiasis: an unusual case of pseudobulbar palsy. (21217721)
2011
9
Disappearance of some human African trypanosomiasis transmission foci in Zambia in the absence of a tsetse fly and trypanosomiasis control program over a period of forty years. (21276598)
2011
10
African trypanosomiasis. (21609334)
2011
11
Potential new drugs for human African trypanosomiasis: some progress at last. (20844428)
2010
12
Identification of Selective Inhibitors of Phosphofructokinase as Lead Compounds Against Trypanosomiasis (24027803)
2010
13
Identification of stage biomarkers for human African trypanosomiasis. (20519589)
2010
14
Novel biomarkers for late-stage human African trypanosomiasis--the search goes on. (20519588)
2010
15
Increased CXCL-13 levels in human African trypanosomiasis meningo-encephalitis. (19298637)
2009
16
Atypical human trypanosomiasis: a neglected disease or just an unlucky accident? (19162551)
2009
17
Justice where justice is due: A posthumous Nobel Prize to Carlos Chagas (1879-1934), the discoverer of American Trypanosomiasis (Chagas' disease). (19185367)
2009
18
Discovery of new S-adenosylmethionine decarboxylase inhibitors for the treatment of Human African Trypanosomiasis (HAT). (19419862)
2009
19
Chemical validation of trypanothione synthetase: a potential drug target for human trypanosomiasis. (19828449)
2009
20
Regulatory T cells prevent control of experimental African trypanosomiasis. (18250461)
2008
21
Contributions of experimental mouse models to the understanding of African trypanosomiasis. (18684669)
2008
22
American trypanosomiasis in dogs from an urban and rural area of Yucatan, Mexico. (18597661)
2008
23
Novel markers for treatment outcome in late-stage Trypanosoma brucei gambiense trypanosomiasis. (18494605)
2008
24
Sleeping glands? - The role of endocrine disorders in sleeping sickness (T.b. gambiense Human African Trypanosomiasis). (17767911)
2007
25
Trypanosomiasis by Trypanosoma vivax in cattle in the Brazilian semiarid: Description of an outbreak and lesions in the nervous system. (16965857)
2007
26
Correlation of the serum concentrations of tumour necrosis factor and nitric oxide with disease severity in chronic Chagas disease (American trypanosomiasis). (17316498)
2007
27
Drugs and drug resistance in African trypanosomiasis. (17409013)
2007
28
Development and evaluation of new diagnostic tests for human African trypanosomiasis. (16671230)
2006
29
Experimental therapy of African trypanosomiasis with a nanobody-conjugated human trypanolytic factor. (16604085)
2006
30
Transfusion-associated Chagas disease (American trypanosomiasis) in Mexico: implications for transfusion medicine in the United States. (16441610)
2006
31
Eflornithine is safer than melarsoprol for the treatment of second-stage Trypanosoma brucei gambiense human African trypanosomiasis. (16080099)
2005
32
Human trypanosomiasis caused by Trypanosoma evansi in India: the first case report. (16172469)
2005
33
Experimental trypanosomiasis in Yankasa ewes: the body weight response. (15977439)
2004
34
Congenital trypanosomiasis. (15537729)
2004
35
American trypanosomiasis (Chagas' disease): an unrecognised cause of stroke. (12640079)
2003
36
Trypanosoma evansi sialidase: surface localization, properties and hydrolysis of ghost red blood cells and brain cells-implications in trypanosomiasis. (12939050)
2003
37
Recent advances in research and control of malaria, leishmaniasis, trypanosomiasis and schistosomiasis. (15748049)
2003
38
Experimental African trypanosomiasis: IFN-gamma mediates early mortality. (12594839)
2003
39
A bloodstream Trypanosoma congolense sialidase could be involved in anemia during experimental trypanosomiasis. (12869528)
2003
40
African trypanosomiasis acquired in an urban area. (14769501)
2003
41
Types of arrhythmia among cases of American trypanosomiasis, compared with those in other cardiology patients. (12803869)
2003
42
American trypanosomiasis (Chagas' disease) and the role of molecular epidemiology in guiding control strategies. (12829559)
2003
43
African trypanosomiasis research: 100 years of progress, but questions and problems still remain. (11334927)
2001
44
Trypanosomiasis control. (11334951)
2001
45
Modeling household transmission of American trypanosomiasis. (11474111)
2001
46
An evaluation of the reactivity of the card agglutination test for trypanosomiasis (CATT) reagent in the Fontem sleeping sickness focus, Cameroon. (7839945)
1994
47
Human African trypanosomiasis (T.b. gambiense): a study of 16 fatal cases of sleeping sickness with some observations on acute reactive arsenical encephalopathy. (3703156)
1986
48
Field evaluation of Cellognost indirect haemagglutination test in the diagnosis of human trypanosomiasis (sleeping sickness) in Kura local government area of Kano State, Nigeria. (2862781)
1985
49
The experimental use of 'sentinel' goats to monitor trypanosomiasis in a Zambian sleeping sickness focus. Part I. The isolation of Trypanosoma brucei rhodesiense-like organisms from a 'sentinel' domestic goat. (6476933)
1984
50
Immunosuppression in experimental trypanosomiasis: effects of Trypanosoma brucei on immunization against louping-ill virus and lymphocytic choriomeningitis virus. (232108)
1979

Variations for Trypanosomiasis

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Expression for genes affiliated with Trypanosomiasis

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Trypanosomiasis

Search GEO for disease gene expression data for Trypanosomiasis.

Pathways for genes affiliated with Trypanosomiasis

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Sources:
50PathCards, 60Thomson Reuters, 30KEGG, 55Reactome, 51PharmGKB, 54R&D Systems, 38NCBI BioSystems Database, 53QIAGEN, 57SinoBiological
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Pathways related to Trypanosomiasis according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0APOA1, APOL1
29.8CD3D, TNFRSF13C
3
Show member pathways
9.7TXN, GSR
4
Show member pathways
9.6IL12A, CD3D
5
Show member pathways
thioredoxin pathway38
9.5GSR, APOA1, TXN
6
Show member pathways
Complement Activation, Classical Pathway38
Complement and Coagulation Cascades38
9.4C1QB, C1QC, C1QA
7
Show member pathways
Immune response Alternative complement pathway60
Immune response Lectin Induced complement pathway60
Immune response Classic complement pathway60
9.4C1QB, C1QC, C1QA
8
Show member pathways
9.4C1QA, C1QC, C1QB
99.4C1QA, C1QC, C1QB
109.4C1QA, C1QC, C1QB
11
Show member pathways
9.4HPR, APOL1, APOA1
12
Show member pathways
9.3TNFRSF13C, IL12A, CD3D
13
Show member pathways
glutathione-mediated detoxification I38
glutathione redox reactions I38
glutathione redox reactions II38
4-hydroxy-2-nonenal detoxification38
Glutathione metabolism60
Glutathione metabolism38
9.3GSR, SRM, PGD, ODC1
14
Show member pathways
9.2APOA1, C1QA, C1QC, C1QB
15
Show member pathways
9.0CD3D, IL12A, CCL3L1, TNFRSF13C
169.0C1QB, C1QC, C1QA, IL12A
178.9APOA1, APOL1, IL12A, HPR
18
Show member pathways
8.5GSR, SRM, PGD, APOA1, TXN, ODC1
19
Show member pathways
Toll-like receptor signaling pathway38
Regulation of toll-like receptor signaling pathway38
8.3CD3D, IL12A, CCL3L1, C1QA, C1QC, C1QB

Compounds for genes affiliated with Trypanosomiasis

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Sources:
45Novoseek, 51PharmGKB, 11DrugBank, 24HMDB
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Compounds related to Trypanosomiasis according to GeneCards/GeneDecks:

(show top 50)    (show all 84)
idCompoundScoreTop Affiliating Genes
11-aminooxy-3-aminopropane4510.1ODC1, SRM
2selenocystine4510.0TXN, GSR
3tositumomab51 1110.9C1QA, C1QC, C1QB
4ibritumomab51 1110.9C1QA, C1QC, C1QB
5alefacept45 1110.9C1QA, C1QC, C1QB
6bevacizumab51 1110.9C1QB, C1QC, C1QA
7gssg459.9GSR, PGD, TXN
8efalizumab45 1110.9C1QA, C1QC, C1QB
9daclizumab45 1110.9C1QB, C1QC, C1QA
10basiliximab45 1110.8C1QA, C1QC, C1QB
11natalizumab45 1110.8C1QB, C1QC, C1QA
12alemtuzumab45 1110.8C1QB, C1QC, C1QA
13gemtuzumab ozogamicin51 45 1111.8C1QA, C1QC, C1QB
14adalimumab45 51 1111.8C1QB, C1QC, C1QA
15selenite459.8TF, TXN, GSR
16gamma-glutamylcysteine45 24 1111.8ODC1, TXN, GSR
17abciximab45 1110.8C1QA, C1QC, C1QB
18gsno459.8GSR, TXN, ODC1
19cetuximab45 51 1111.8C1QB, C1QC, C1QA
20rotenone459.8ODC1, TXN, GSR
21etanercept45 51 1111.7C1QA, C1QC, C1QB
22methotrexate51 45 1111.7TF, ODC1, PGD, GSR
23dehydroascorbic acid45 1110.7TF, TXN, PGD, GSR
24betacarotene459.6TF, ODC1, TXN, GSR
25tocopherol459.6TF, TXN, APOA1, GSR
26cadaverine45 2410.6ODC1, SRM
27selenium45 2410.6TF, TXN, GSR
28citrate459.6TF, ODC1, TXN, PGD
29adriamycin459.6GSR, TXN, ODC1, TF
30trastuzumab45 51 1111.6C1QB, C1QC, C1QA
31thyroxine45 2410.5GSR, APOA1, TXN, TF
32fructose-1,6-bisphosphate459.5TXN, HPR, GSR
334-hydroxynonenal45 2410.5GSR, TXN, ODC1
34vitamin a45 24 1111.5GSR, APOA1, TXN, TF
35rituximab45 51 1111.4C1QA, C1QC, C1QB
36trypanothione45 1110.4GSR, SRM, TXN, ODC1
37alpha tocopherol459.4TF, ODC1, TXN, APOA1, GSR
38n acetylcysteine459.3TF, ODC1, TXN, GSR
39glyceraldehyde 3-phosphate459.3ODC1, PGD, PREP, GSR
40carbohydrates459.2TF, ODC1, TXN, HPR
41ascorbic acid45 2410.2TF, ODC1, TXN, APOA1, PGD, GSR
42lactate459.2TF, ODC1, TXN, APOA1, PGD, GSR
43aspartate459.2TF, ODC1, TXN, APOA1, PGD, GSR
44pge1459.2TXN, ODC1, TF
45h2o2459.1ODC1, TXN, APOA1, PGD, GSR
46gnrh458.9GSR, PREP, TXN, ODC1
47adenylate458.8ODC1, TXN, PGD, HPR, GSR
48estrogen458.6TF, ODC1, TXN, APOA1, HPR, GSR
49glutamate458.4TF, ODC1, TXN, APOA1, PGD, PREP
50alanine458.1TF, TXN, APOA1, PREP, HPR, GSR

GO Terms for genes affiliated with Trypanosomiasis

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Sources:
16Gene Ontology
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Cellular components related to Trypanosomiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1complement component C1 complexGO:00560210.0C1QA, C1QB
2secretory granule lumenGO:03477410.0APOA1, TF
3very-low-density lipoprotein particleGO:0343619.9APOL1, APOA1
4high-density lipoprotein particleGO:0343649.7APOA1, APOL1
5spherical high-density lipoprotein particleGO:0343669.7HPR, APOA1
6collagenGO:0055819.5C1QB, C1QC, C1QA
7extracellular spaceGO:0056158.9IL12A, APOL1, APOA1, C1QC, TF
8blood microparticleGO:0725628.6HPR, TF, C1QB, C1QC, APOA1, APOL1
9extracellular regionGO:0055768.2TF, C1QB, C1QC, C1QA, APOA1, APOL1

Biological processes related to Trypanosomiasis according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1lipoprotein metabolic processGO:04215710.0APOL1, APOA1
2polyamine metabolic processGO:0065959.6SRM, ODC1
3complement activationGO:0069569.6C1QA, C1QC, C1QB
4complement activation, classical pathwayGO:0069589.5C1QA, C1QC, C1QB
5nucleobase-containing small molecule interconversionGO:0159499.4GSR, TXN
6innate immune responseGO:0450878.8C1QB, C1QC, C1QA, TXN, APOL1
7small molecule metabolic processGO:0442818.5ODC1, TXN, APOA1, PGD, SRM, GSR

Molecular functions related to Trypanosomiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1NADP bindingGO:05066110.0GSR, PGD

Products for genes affiliated with Trypanosomiasis

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  • Antibodies
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Sources for Trypanosomiasis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet