MCID: TRY001
MIFTS: 42

Trypanosomiasis malady

Summaries for Trypanosomiasis

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Disease Ontology:9 A parasitic protozoa infectious disease that involves infection caused by parasitic protozoan of the genus trypanosoma in animals and humans.

MalaCards based summary: Trypanosomiasis is related to chagas disease and sleeping sickness. An important gene associated with Trypanosomiasis is APOL1 (apolipoprotein L, 1), and among its related pathways are Cholesterol and Sphingolipids transport Recycling to plasma membrane in lung normal and CF and Primary immunodeficiency. The drugs pentamidine and pentamidine isethionate and the compounds 1-aminooxy-3-aminopropane and selenocystine have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and t cells.

Wikipedia:63 Trypanosomiasis or trypanosomosis is the name of several diseases in vertebrates caused by parasitic... more...

Aliases & Classifications for Trypanosomiasis

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Sources:
9Disease Ontology, 43Novoseek, 60UMLS, 33MeSH, 27ICD9CM, 55SNOMED-CT
See all sources

Trypanosomiasis, Aliases & Descriptions:

Name: Trypanosomiasis 9 43 60


External Ids:

Disease Ontology9 DOID:10113
MeSH33 D014352
ICD9CM27 086.9, 086

Related Diseases for Trypanosomiasis

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Diseases related to Trypanosomiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 52)
idRelated DiseaseScoreTop Affiliating Genes
1chagas disease31.6ODC1, SRM, GSR
2sleeping sickness31.5ODC1, APOL1, SRM, HPR
3leishmaniasis31.4PGD, SRM
4malaria31.0GSR, HPR, SRM, ODC1
5glucosephosphate dehydrogenase deficiency10.4GSR, HPR
6gastric ulcer10.3GSR, ODC1
7cerebritis10.3
8trypanosomiasis, human east-african10.3
9thalassemia, hispanic gamma-delta-beta10.3GSR, TF
10kidney disease10.2HPR, APOL1, APOA1
11amebiasis10.2
12encephalitis10.2
13schistosomiasis10.2
14trypanosomiasis, human west-african10.2
15hepatitis10.2TF, TXN, GSR
16acute respiratory distress syndrome10.2TXN, TF
17fatty liver disease10.2TF, TXN, APOA1
18hepatitis c10.2GSR, TXN, TF
19congenital heart disease10.2TXN, APOA1, GSR
20acute myocardial infarction10.2GSR, APOA1, TXN
21b-cell lymphomas10.1TNFRSF13C, TXN, SRM
22babesiosis10.1
23trichinosis10.1
24louping ill10.1
25toxoplasmosis10.1
26schizophrenia10.1ODC1, APOL1, PREP, GSR
27hepatitis b10.1GSR, APOA1, TXN
28vascular disease10.1GSR, HPR, TXN, TF
29primary hyperoxaluria10.0TF, ODC1, APOA1, GSR
30deficiency anemia10.0TF, TXN, PGD, HPR, GSR
31chronic kidney failure10.0GSR, APOA1, TF
32hiv-110.0
33cutaneous leishmaniasis10.0
34trichomoniasis10.0
35orchitis10.0
36neuronitis10.0
37endomyocardial fibrosis10.0
38onchocerciasis10.0
39pseudobulbar palsy10.0
40loiasis10.0
41lymphocytic choriomeningitis10.0
42filariasis10.0
43megacolon10.0
44microsporidiosis10.0
45myocarditis10.0
46relapsing fever10.0
47tuberculosis10.0
48yaws10.0
49endotheliitis10.0
50diabetes mellitus, insulin-dependent10.0GSR, HPR, APOA1, TXN, TF

Graphical network of the top 20 diseases related to Trypanosomiasis:



Diseases related to trypanosomiasis

Symptoms for Trypanosomiasis

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Drugs & Therapeutics for Trypanosomiasis

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Drug clinical trials:

Search ClinicalTrials for Trypanosomiasis

Search NIH Clinical Center for Trypanosomiasis

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Trypanosomiasis

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Anatomical Context for Trypanosomiasis

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MalaCards organs/tissues related to Trypanosomiasis:

31
Testes, Brain, T cells, Heart, Colon, Skin, Myeloid, B cells, Endothelial

Animal Models for Trypanosomiasis or affiliated genes

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Publications for Trypanosomiasis

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Articles related to Trypanosomiasis:

(show top 50)    (show all 565)
idTitleAuthorsYear
1
Nanobody conjugated PLGA nanoparticles for active targeting of African Trypanosomiasis. (25445702)
2015
2
Trypanosomiasis-induced megacolon illustrates how myenteric neurons modulate the risk for colon cancer in rats and humans. (25884710)
2015
3
Delivery of Antihuman African Trypanosomiasis Drugs Across the Blood-Brain and Blood-CSF Barriers. (25307219)
2014
4
Oral Multicomponent DNA Vaccine Delivered by Attenuated Salmonella Elicited Immunoprotection Against American Trypanosomiasis. (25160983)
2014
5
Social factors affecting seasonal variation in bovine trypanosomiasis on the Jos Plateau, Nigeria. (24172046)
2013
6
An exploratory GIS-based method to identify and characterise landscapes with an elevated epidemiological risk of Rhodesian human African trypanosomiasis. (23171150)
2012
7
Modeling the control of trypanosomiasis using trypanocides or insecticide-treated livestock. (22616017)
2012
8
Trypanosomiasis in an infant from India. (21715739)
2011
9
Transmission of human African trypanosomiasis in the Komo-Mondah focus, Gabon. (22121444)
2011
10
Dental management of the tropical disease human African trypanosomiasis: an unusual case of pseudobulbar palsy. (21217721)
2011
11
Disappearance of some human African trypanosomiasis transmission foci in Zambia in the absence of a tsetse fly and trypanosomiasis control program over a period of forty years. (21276598)
2011
12
African trypanosomiasis. (21609334)
2011
13
Potential new drugs for human African trypanosomiasis: some progress at last. (20844428)
2010
14
Identification of Selective Inhibitors of Phosphofructokinase as Lead Compounds Against Trypanosomiasis (24027803)
2010
15
Identification of stage biomarkers for human African trypanosomiasis. (20519589)
2010
16
Increased CXCL-13 levels in human African trypanosomiasis meningo-encephalitis. (19298637)
2009
17
Atypical human trypanosomiasis: a neglected disease or just an unlucky accident? (19162551)
2009
18
Justice where justice is due: A posthumous Nobel Prize to Carlos Chagas (1879-1934), the discoverer of American Trypanosomiasis (Chagas' disease). (19185367)
2009
19
Discovery of new S-adenosylmethionine decarboxylase inhibitors for the treatment of Human African Trypanosomiasis (HAT). (19419862)
2009
20
Chemical validation of trypanothione synthetase: a potential drug target for human trypanosomiasis. (19828449)
2009
21
Regulatory T cells prevent control of experimental African trypanosomiasis. (18250461)
2008
22
Contributions of experimental mouse models to the understanding of African trypanosomiasis. (18684669)
2008
23
American trypanosomiasis in dogs from an urban and rural area of Yucatan, Mexico. (18597661)
2008
24
Novel markers for treatment outcome in late-stage Trypanosoma brucei gambiense trypanosomiasis. (18494605)
2008
25
Sleeping glands? - The role of endocrine disorders in sleeping sickness (T.b. gambiense Human African Trypanosomiasis). (17767911)
2007
26
Trypanosomiasis by Trypanosoma vivax in cattle in the Brazilian semiarid: Description of an outbreak and lesions in the nervous system. (16965857)
2007
27
Correlation of the serum concentrations of tumour necrosis factor and nitric oxide with disease severity in chronic Chagas disease (American trypanosomiasis). (17316498)
2007
28
Drugs and drug resistance in African trypanosomiasis. (17409013)
2007
29
Development and evaluation of new diagnostic tests for human African trypanosomiasis. (16671230)
2006
30
Experimental therapy of African trypanosomiasis with a nanobody-conjugated human trypanolytic factor. (16604085)
2006
31
Transfusion-associated Chagas disease (American trypanosomiasis) in Mexico: implications for transfusion medicine in the United States. (16441610)
2006
32
Eflornithine is safer than melarsoprol for the treatment of second-stage Trypanosoma brucei gambiense human African trypanosomiasis. (16080099)
2005
33
Human trypanosomiasis caused by Trypanosoma evansi in India: the first case report. (16172469)
2005
34
Experimental trypanosomiasis in Yankasa ewes: the body weight response. (15977439)
2004
35
Congenital trypanosomiasis. (15537729)
2004
36
American trypanosomiasis (Chagas' disease): an unrecognised cause of stroke. (12640079)
2003
37
Trypanosoma evansi sialidase: surface localization, properties and hydrolysis of ghost red blood cells and brain cells-implications in trypanosomiasis. (12939050)
2003
38
Recent advances in research and control of malaria, leishmaniasis, trypanosomiasis and schistosomiasis. (15748049)
2003
39
Experimental African trypanosomiasis: IFN-gamma mediates early mortality. (12594839)
2003
40
A bloodstream Trypanosoma congolense sialidase could be involved in anemia during experimental trypanosomiasis. (12869528)
2003
41
African trypanosomiasis acquired in an urban area. (14769501)
2003
42
Types of arrhythmia among cases of American trypanosomiasis, compared with those in other cardiology patients. (12803869)
2003
43
African trypanosomiasis research: 100 years of progress, but questions and problems still remain. (11334927)
2001
44
Trypanosomiasis control. (11334951)
2001
45
Modeling household transmission of American trypanosomiasis. (11474111)
2001
46
An evaluation of the reactivity of the card agglutination test for trypanosomiasis (CATT) reagent in the Fontem sleeping sickness focus, Cameroon. (7839945)
1994
47
Human African trypanosomiasis (T.b. gambiense): a study of 16 fatal cases of sleeping sickness with some observations on acute reactive arsenical encephalopathy. (3703156)
1986
48
Field evaluation of Cellognost indirect haemagglutination test in the diagnosis of human trypanosomiasis (sleeping sickness) in Kura local government area of Kano State, Nigeria. (2862781)
1985
49
The experimental use of 'sentinel' goats to monitor trypanosomiasis in a Zambian sleeping sickness focus. Part I. The isolation of Trypanosoma brucei rhodesiense-like organisms from a 'sentinel' domestic goat. (6476933)
1984
50
Immunosuppression in experimental trypanosomiasis: effects of Trypanosoma brucei on immunization against louping-ill virus and lymphocytic choriomeningitis virus. (232108)
1979

Variations for Trypanosomiasis

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Expression for genes affiliated with Trypanosomiasis

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Search GEO for disease gene expression data for Trypanosomiasis.

Pathways for genes affiliated with Trypanosomiasis

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Pathways related to Trypanosomiasis according to GeneCards Suite gene sharing:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0APOA1, APOL1
29.8CD3D, TNFRSF13C
3
Show member pathways
9.7TXN, GSR
4
Show member pathways
9.6IL12A, CD3D
5
Show member pathways
thioredoxin pathway36
9.5GSR, APOA1, TXN
6
Show member pathways
Complement Activation, Classical Pathway36
Complement and Coagulation Cascades36
9.4C1QB, C1QC, C1QA
7
Show member pathways
Immune response Alternative complement pathway58
Immune response Lectin Induced complement pathway58
Immune response Classic complement pathway58
9.4C1QB, C1QC, C1QA
8
Show member pathways
9.4C1QA, C1QC, C1QB
99.4C1QA, C1QC, C1QB
109.4C1QA, C1QC, C1QB
11
Show member pathways
9.4HPR, APOL1, APOA1
12
Show member pathways
9.3TNFRSF13C, IL12A, CD3D
13
Show member pathways
glutathione-mediated detoxification I36
glutathione redox reactions I36
glutathione redox reactions II36
4-hydroxy-2-nonenal detoxification36
Glutathione metabolism58
Glutathione metabolism36
9.3GSR, SRM, PGD, ODC1
14
Show member pathways
9.2APOA1, C1QA, C1QC, C1QB
15
Show member pathways
9.0CD3D, IL12A, CCL3L1, TNFRSF13C
169.0C1QB, C1QC, C1QA, IL12A
178.9APOA1, APOL1, IL12A, HPR
18
Show member pathways
8.5GSR, SRM, PGD, APOA1, TXN, ODC1
19
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
8.3CD3D, IL12A, CCL3L1, C1QA, C1QC, C1QB

Compounds for genes affiliated with Trypanosomiasis

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Sources:
43Novoseek, 49PharmGKB, 12DrugBank, 24HMDB
See all sources

Compounds related to Trypanosomiasis according to GeneCards Suite gene sharing:

(show top 50)    (show all 84)
idCompoundScoreTop Affiliating Genes
11-aminooxy-3-aminopropane4310.1SRM, ODC1
2selenocystine4310.0GSR, TXN
3tositumomab49 1210.9C1QC, C1QA, C1QB
4ibritumomab49 1210.9C1QC, C1QA, C1QB
5alefacept43 1210.9C1QA, C1QC, C1QB
6bevacizumab49 1210.9C1QC, C1QB, C1QA
7gssg439.9TXN, GSR, PGD
8efalizumab43 1210.9C1QA, C1QC, C1QB
9daclizumab43 1210.9C1QB, C1QA, C1QC
10basiliximab43 1210.8C1QA, C1QC, C1QB
11alemtuzumab43 1210.8C1QB, C1QC, C1QA
12natalizumab43 1210.8C1QA, C1QC, C1QB
13gemtuzumab ozogamicin49 43 1211.8C1QA, C1QC, C1QB
14adalimumab43 49 1211.8C1QB, C1QC, C1QA
15selenite439.8TF, GSR, TXN
16gamma-glutamylcysteine43 24 1211.8ODC1, TXN, GSR
17abciximab43 1210.8C1QB, C1QA, C1QC
18gsno439.8TXN, ODC1, GSR
19cetuximab43 49 1211.8C1QC, C1QB, C1QA
20rotenone439.8ODC1, TXN, GSR
21etanercept43 49 1211.7C1QB, C1QC, C1QA
22methotrexate49 43 1211.7GSR, TF, ODC1, PGD
23dehydroascorbic acid43 1210.7GSR, TF, TXN, PGD
24betacarotene439.6GSR, TXN, ODC1, TF
25tocopherol439.6GSR, TF, APOA1, TXN
26cadaverine43 2410.6SRM, ODC1
27selenium43 2410.6GSR, TF, TXN
28citrate439.6PGD, TXN, ODC1, TF
29adriamycin439.6TF, ODC1, TXN, GSR
30trastuzumab43 49 1211.6C1QB, C1QA, C1QC
31thyroxine43 2410.5GSR, TXN, APOA1, TF
32fructose-1,6-bisphosphate439.5GSR, HPR, TXN
334-hydroxynonenal43 2410.5TXN, GSR, ODC1
34vitamin a43 24 1211.5TXN, GSR, APOA1, TF
35rituximab43 49 1211.4C1QB, C1QC, C1QA
36trypanothione43 1210.4ODC1, TXN, SRM, GSR
37alpha tocopherol439.4GSR, APOA1, TXN, ODC1, TF
38n acetylcysteine439.3ODC1, GSR, TXN, TF
39glyceraldehyde 3-phosphate439.3ODC1, PGD, PREP, GSR
40carbohydrates439.2TXN, HPR, TF, ODC1
41ascorbic acid43 2410.2ODC1, TXN, APOA1, PGD, GSR, TF
42lactate439.2ODC1, TF, TXN, APOA1, PGD, GSR
43aspartate439.2TXN, APOA1, TF, ODC1, PGD, GSR
44pge1439.2TXN, TF, ODC1
45h2o2439.1GSR, PGD, APOA1, TXN, ODC1
46gnrh438.9GSR, PREP, ODC1, TXN
47adenylate438.8PGD, TXN, ODC1, HPR, GSR
48estrogen438.6ODC1, TXN, APOA1, HPR, GSR, TF
49glutamate438.4GSR, PGD, APOA1, PREP, ODC1, TF
50alanine438.1GSR, HPR, PREP, APOA1, TXN, TF

GO Terms for genes affiliated with Trypanosomiasis

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Cellular components related to Trypanosomiasis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1complement component C1 complexGO:000560210.0C1QA, C1QB
2secretory granule lumenGO:003477410.0APOA1, TF
3very-low-density lipoprotein particleGO:00343619.9APOL1, APOA1
4high-density lipoprotein particleGO:00343649.7APOA1, APOL1
5spherical high-density lipoprotein particleGO:00343669.7HPR, APOA1
6collagenGO:00055819.5C1QB, C1QC, C1QA
7extracellular spaceGO:00056158.9IL12A, APOL1, APOA1, C1QC, TF
8blood microparticleGO:00725628.6HPR, TF, C1QB, C1QC, APOA1, APOL1
9extracellular regionGO:00055768.2TF, C1QB, C1QC, C1QA, APOA1, APOL1

Biological processes related to Trypanosomiasis according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1lipoprotein metabolic processGO:004215710.0APOL1, APOA1
2polyamine metabolic processGO:00065959.6SRM, ODC1
3complement activationGO:00069569.6C1QA, C1QC, C1QB
4complement activation, classical pathwayGO:00069589.5C1QA, C1QC, C1QB
5nucleobase-containing small molecule interconversionGO:00159499.4GSR, TXN
6innate immune responseGO:00450878.8C1QB, C1QC, C1QA, TXN, APOL1
7small molecule metabolic processGO:00442818.5ODC1, TXN, APOA1, PGD, SRM, GSR

Molecular functions related to Trypanosomiasis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1NADP bindingGO:005066110.0GSR, PGD

Products for genes affiliated with Trypanosomiasis

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Sources for Trypanosomiasis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet