MCID: TRY001
MIFTS: 50

Trypanosomiasis malady

Summaries for Trypanosomiasis

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A parasitic protozoa infectious disease that involves infection caused by parasitic protozoan of the genus trypanosoma in animals and humans.

MalaCards: Trypanosomiasis is related to sleeping sickness and chagas disease. An important gene associated with Trypanosomiasis is APOL1 (apolipoprotein L, 1), and among its related pathways are African trypanosomiasis and PEDF Induced Signaling. The drugs pentamidine and pentamidine isethionate and the compounds aspartate and ascorbic acid have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and t cells.

Wikipedia:63 Trypanosomiasis or trypanosomosis is the name of several diseases in vertebrates caused by parasitic... more...

Aliases & Classifications for Trypanosomiasis

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8Disease Ontology, 44Novoseek, 60UMLS, 27ICD9CM, 56SNOMED-CT, 34MeSH
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Aliases & Descriptions:

trypanosomiasis 8 44 60


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Disease Ontology8 DOID:10113
ICD9CM27 086, 086.9
MeSH34 D014352

Related Diseases for Trypanosomiasis

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17GeneCards, 18GeneDecks
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Diseases related to Trypanosomiasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 79)
idRelated DiseaseScoreTop Affiliating Genes
1sleeping sickness31.1SRM, HPR, APOL1, ODC1
2chagas disease31.0ODC1, GAPDH, SRM, GSR
3leishmaniasis30.8PGD, SRM
4malaria30.6ODC1, GAPDH, HPR, SRM, GSR
5tuberculosis29.8GAPDH, HPR, GSR
6cerebritis10.1
7amebiasis10.1
8encephalitis10.1
9trypanosomiasis, human east-african10.1
10babesiosis10.1
11trichinosis10.1
12louping ill10.1
13schistosomiasis10.1
14toxoplasmosis10.1
15trypanosomiasis, human west-african10.1
16deficiency anemia10.0TXN, GAPDH, TF, HPR, PGD, GSR
17schizophrenia10.0ODC1, APOL1, GAPDH, PREP, TACR1, GSR
18diabetes mellitus10.0TXN, APOA1, GAPDH, TF, HPR, GSR
19alzheimer's disease10.0GSR, TACR1, PREP, GAPDH, TXN
20vascular disease10.0TXN, GAPDH, TF, HPR, GSR
21rheumatoid arthritis10.0TXN, TNFRSF13C, APOA1, TACR1
22arthritis10.0TACR1, HPR, TXN
23hepatitis b10.0GSR, APOA1, TXN
24asthma10.0GAPDH, TACR1, GSR
25leukemia10.0GAPDH, ODC1
26multiple sclerosis10.0GSR, APOA1, TNFRSF13C
27glucosephosphate dehydrogenase deficiency10.0GSR, HPR
28cataract10.0TXN, GAPDH, GSR
29osteoarthritis10.0TACR1, GSR
30acute myocardial infarction10.0TXN, APOA1, GSR
31hepatocellular carcinoma10.0TF, GAPDH, TXN
32sarcoma10.0ODC1, GAPDH
33pneumonia10.0TXN
34breast cancer10.0ODC1, TXN, GAPDH, HPR, GSR
35glioblastoma multiforme10.0TACR1, GAPDH, ODC1
36atherosclerosis10.0APOA1, TXN
37influenza10.0TXN
38adenocarcinoma10.0ODC1, GAPDH, TACR1
39psoriasis10.0ODC1, TACR1
40ischemia10.0GSR
41infertility10.0GAPDH
42hepatitis10.0TXN, TF, GSR
43hyperglycemia10.0TXN
44cholera10.0TF, ODC1
45pancreatitis10.0TACR1
46galactosemia10.0HPR, TF
47coronary heart disease10.0APOA1, GSR
48fatty liver disease10.0TF, APOA1, TXN
49malignant glioma10.0ODC1, CCL3L1, PREP, TACR1, GSR
50acute pancreatitis10.0TACR1

Graphical network of the top 20 diseases related to Trypanosomiasis:



Diseases related to trypanosomiasis

Clinical Features for Trypanosomiasis

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Drugs & Therapeutics for Trypanosomiasis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Trypanosomiasis

Drug clinical trials:

Search ClinicalTrials for Trypanosomiasis

Search NIH Clinical Center for Trypanosomiasis

Search CenterWatch for Trypanosomiasis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Trypanosomiasis

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Anatomical Context for Trypanosomiasis

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32MalaCards
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MalaCards organs/tissues related to Trypanosomiasis:

32
Testes, Brain, T cells, Heart, Skin, Myeloid, B cells, Endothelial

Animal Models for Trypanosomiasis or affiliated genes

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Publications for Trypanosomiasis

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50PubMed
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Articles related to Trypanosomiasis:

(show top 50)    (show all 527)
idTitleAuthorsYear
1
Activity of diimidazoline amides against African trypanosomiasis. (24398295)
2013
2
An exploratory GIS-based method to identify and characterise landscapes with an elevated epidemiological risk of Rhodesian human African trypanosomiasis. (23171150)
2012
3
Diagnostic accuracy of molecular amplification tests for human African trypanosomiasis--systematic review. (22253934)
2012
4
American trypanosomiasis (Chagas disease). (22632639)
2012
5
Human African trypanosomiasis in a Belgian traveller returning from the Masai Mara area, Kenya, February 2012. (22433595)
2012
6
Stoking the drug target pipeline for human African trypanosomiasis. (22925123)
2012
7
Tsetse fly control and trypanosomiasis in Africa, quo vadis? (21104211)
2011
8
Human African trypanosomiasis: a review of non-endemic cases in the past 20 years. (21683638)
2011
9
Outbreaks of trypanosomiasis and the seroprevalence of T. evansi in a deer breeding centre in Perak, Malaysia. (19642008)
2010
10
Bayesian geostatistical analysis and prediction of Rhodesian human African trypanosomiasis. (21200429)
2010
11
Metal-based drugs for malaria, trypanosomiasis and leishmaniasis: recent achievements and perspectives. (20974285)
2010
12
How can tsetse population genetics contribute to African trypanosomiasis control? (20202905)
2010
13
Cross-resistance to nitro drugs and implications for treatment of human African trypanosomiasis. (20439607)
2010
14
Scrutinizing the mechanisms underlying the induction of anemia of inflammation through GPI-mediated modulation of macrophage activation in a model of African trypanosomiasis. (20197106)
2010
15
Justice where justice is due: A posthumous Nobel Prize to Carlos Chagas (1879-1934), the discoverer of American Trypanosomiasis (Chagas' disease). (19185367)
2009
16
Spatial predictions of Rhodesian Human African Trypanosomiasis (sleeping sickness) prevalence in Kaberamaido and Dokolo, two newly affected districts of Uganda. (20016846)
2009
17
African trypanosomiasis and antibodies: implications for vaccination, therapy and diagnosis. (19824795)
2009
18
Novel markers for treatment outcome in late-stage Trypanosoma brucei gambiense trypanosomiasis. (18494605)
2008
19
Neglected diseases in the news: a content analysis of recent international media coverage focussing on leishmaniasis and trypanosomiasis. (18478048)
2008
20
Trypanosomiasis-induced B cell apoptosis results in loss of protective anti-parasite antibody responses and abolishment of vaccine-induced memory responses. (18516300)
2008
21
The anti-oxidant defence response in individuals with the indeterminate form of Chagas disease (American trypanosomiasis). (18348773)
2008
22
Seasonal variation in human African trypanosomiasis in Tarangire National Park in Babati district, Tanzania. (17722418)
2007
23
Skin features accompanying imported human African trypanosomiasis: hemolymphatic Trypanosoma gambiense infection among two French expatriates with dermatologic manifestations. (17437477)
2007
24
Manifestations of Chagas disease (American trypanosomiasis) in patients with HIV/AIDS. (17244408)
2007
25
Cost-effectiveness of algorithms for confirmation test of human African trypanosomiasis. (18257991)
2007
26
African trypanosomiasis: naturally occurring regulatory T cells favor trypanotolerance by limiting pathology associated with sustained type 1 inflammation. (17709488)
2007
27
Stroke: a neglected complication of American trypanosomiasis (Chagas' disease). (17663015)
2007
28
Experimental therapy of African trypanosomiasis with a nanobody-conjugated human trypanolytic factor. (16604085)
2006
29
Randomized controlled trial of three regimens of melarsoprol in the treatment of Trypanosoma brucei gambiense trypanosomiasis. (16483622)
2006
30
Parenteral transmission during excision and treatment of tuberculosis and trypanosomiasis may be responsible for the HIV-2 epidemic in Guinea-Bissau. (16816560)
2006
31
Short report: Human trypanosomiasis caused by Trypanosoma evansi in a village in India: preliminary serologic survey of the local population. (17123979)
2006
32
Diagnosing human African trypanosomiasis in Angola using a card agglutination test: observational study of active and passive case finding strategies. (16777858)
2006
33
Itraconazole or allopurinol in the treatment of chronic American trypanosomiasis: the results of clinical and parasitological examinations 11 years post-treatment. (16297286)
2005
34
Human African trypanosomiasis: emergency action in southern Sudan. (15571175)
2004
35
History of sleeping sickness (African trypanosomiasis). (15145378)
2004
36
African trypanosomiasis acquired in an urban area. (14769501)
2003
37
Clinical follow-up in the rat experimental model of African trypanosomiasis. (14681551)
2003
38
Stage determination and therapeutic decision in human African trypanosomiasis: value of polymerase chain reaction and immunoglobulin M quantification on the cerebrospinal fluid of sleeping sickness patients in CA'te d'Ivoire. (12828540)
2003
39
Case definitions. African trypanosomiasis (sleeping sickness). (15112631)
2003
40
Recent developments in human African trypanosomiasis. (12686879)
2002
41
Control of human African trypanosomiasis in the QuiAsama focus, Angola. (12378293)
2002
42
Genetic characterization of Trypanosoma brucei gambiense and clinical evolution of human African trypanosomiasis in CA'te d'Ivoire. (12100445)
2002
43
Clinical description of encephalopathic syndromes and risk factors for their occurrence and outcome during melarsoprol treatment of human African trypanosomiasis. (11348533)
2001
44
Sylvatic focus of American Trypanosomiasis in the State of Morelos, Mexico. (11935921)
2001
45
Geographic Information Systems and the Selection of Priority Areas for Control of Tsetse-transmitted Trypanosomiasis in Africa. (17040848)
1998
46
Drug used in the treatment of sleeping sickness (human African trypanosomiasis: HAT). (18611614)
1994
47
Prevalence of domestic animal trypanosomiasis in the Fontem sleeping sickness focus, Cameroon. (2263747)
1990
48
Amebiasis and trypanosomiasis. (2504524)
1989
49
Mixed outbreak of trypanosomiasis and babesiosis in pigs in Nigeria. (3194972)
1988
50
The experimental use of 'sentinel' goats to monitor trypanosomiasis in a Zambian sleeping sickness focus. Part I. The isolation of Trypanosoma brucei rhodesiense-like organisms from a 'sentinel' domestic goat. (6476933)
1984

Genetic Variations for Trypanosomiasis

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Expression for genes affiliated with Trypanosomiasis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Trypanosomiasis

Search GEO for disease gene expression data for Trypanosomiasis.

Pathways for genes affiliated with Trypanosomiasis

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29KEGG, 51QIAGEN, 37NCBI BioSystems Database, 12EMD Millipore, 53Reactome, 49PharmGKB
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Compounds for genes affiliated with Trypanosomiasis

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44Novoseek, 24HMDB, 11DrugBank, 28IUPHAR, 49PharmGKB
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Compounds related to Trypanosomiasis according to GeneCards/GeneDecks:

(show top 50)    (show all 72)
idCompoundScoreTop Affiliating Genes
1aspartate4411.2TXN, GSR, TACR1, PGD, TF, GAPDH
2ascorbic acid44 2412.2TF, PGD, APOA1, GSR, ODC1, TXN
3alanine4411.1GSR, TXN, TACR1, HPR, PREP, TF
4lactate4411.1TXN, APOA1, GAPDH, GSR, TF, PGD
5adenylate4411.1HPR, GAPDH, GSR, TACR1, PGD, TXN
6alpha tocopherol4411.1TXN, APOA1, TF, GSR, ODC1
7trypanothione44 1112.1SRM, TXN, GSR, ODC1
8citrate4411.1TXN, PGD, TF, GAPDH, ODC1
9dehydroascorbic acid44 1112.1TF, TXN, PGD, GSR
10glyceraldehyde 3-phosphate4411.0GAPDH, PGD, GSR, PREP, ODC1
11tocopherol4411.0TF, TXN, APOA1, GSR
12vitamin a44 11 2413.0GSR, TXN, APOA1, GAPDH, TF
13fructose-1,6-bisphosphate4411.0GSR, HPR, TXN, GAPDH
14gssg4411.0PGD, GAPDH, TXN, GSR
15gsno4411.0TXN, ODC1, GAPDH, GSR
16n acetylcysteine4411.0ODC1, GSR, TF, GAPDH, TXN
17betacarotene4411.0TXN, TF, GSR, ODC1
18glutamate4411.0PREP, TACR1, APOA1
194-hydroxynonenal44 2412.0GSR, GAPDH, TXN, ODC1
20ornithine44 2412.0SRM, GAPDH, ODC1, PREP
21gnrh4411.0GSR, THOP1, PREP
22diamide4411.0GSR, TXN, GAPDH
236-phosphogluconate4411.0PGD, GSR, GAPDH
24adriamycin4411.0TF, GSR, ODC1, TXN
25selenite4410.9TF, GSR, TXN
26tert-butylhydroperoxide4410.9GAPDH, GSR, TXN
27nadp+4410.9PGD, GAPDH, GSR
28adenine44 11 2412.9GSR, TF, GAPDH, ODC1
29h2o24410.9PGD, ODC1, GAPDH
30carbohydrates4410.9TXN, HPR, TF, ODC1
31pssg4410.9GSR, GAPDH
321-aminooxy-3-aminopropane4410.9SRM, ODC1
33thyroxine44 2411.9TXN, APOA1, TF, GSR
34gamma-glutamylcysteine44 11 2412.9ODC1, GSR, TXN
35glutamine4410.9TXN, TF, TACR1, ODC1, GAPDH
36selenocystine4410.9GSR, TXN
37rotenone4410.9GSR, ODC1, TXN
38glyoxal4410.8GAPDH, GSR
39acetaldehyde44 28 2412.8APOA1, GAPDH, TF
40methotrexate44 49 1112.8GSR, ODC1, TF, PGD
41nicotinamide44 1111.8TXN, GAPDH, GSR
42malate4410.8PGD, TXN, GAPDH
43creatinine4410.7GSR, GAPDH, APOA1, TXN, TF
44selenium44 2411.7GSR, TF, TXN
45cadaverine44 2411.7ODC1, SRM
46mechlorethamine4410.6APOA1, GAPDH
47deet4410.5ODC1, GAPDH
48lipoamide44 2411.5TXN, GSR
49guanidine hydrochloride4410.5GAPDH, APOA1, GSR
50peroxynitrite4410.3GAPDH, TXN, GSR

GO Terms for genes affiliated with Trypanosomiasis

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16Gene Ontology
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Cellular components related to Trypanosomiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.7TXN, CCL3L3, APOA1, APOL1, TF, HPR
2spherical high-density lipoprotein particleGO:03436610.4HPR, APOA1
3secretory granule lumenGO:03477410.2TF, APOA1

Biological processes related to Trypanosomiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1small molecule metabolic processGO:04428110.7GSR, ODC1, TXN, APOA1, GAPDH, PGD
2nucleobase-containing small molecule interconversionGO:01594910.5GSR, TXN
3positive regulation of lymphocyte proliferationGO:05067110.4TACR1, IL12A
4polyamine metabolic processGO:00659510.2SRM, ODC1

Molecular functions related to Trypanosomiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1NADP bindingGO:05066110.6GSR, PGD, GAPDH

Products for genes affiliated with Trypanosomiasis

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  • Antibodies
  • Proteins
  • Lysates
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Sources for Trypanosomiasis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet