Trypanosomiasis malady

Disease Ontology: A parasitic protozoa infectious disease that involves infection caused by parasitic protozoan of the genus trypanosoma in animals and humans.⁶

MalaCards: Trypanosomiasis is related to sleeping sickness and malaria. An important gene associated with Trypanosomiasis is APOL1 (apolipoprotein L, 1), and among its related pathways are Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1 and Pancreatic cancer. The drugs pentamidine and pentamidine isethionate and the compounds glucose and nadph have been mentioned in the context of this disorder. Affiliated tissues include brain and b cells, and related mouse phenotypes are hematopoietic system and respiratory system.

Wikipedia: Trypanosomiasis or trypanosomosis is the name of several diseases in vertebrates caused by parasitic...⁴⁴ more...

Aliases & Descriptions:

trypanosomiasis 6 32 43

Diseases related to trypanosomiasis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 703)

id	Related Disease	Score	Top Affiliating Genes
1	sleeping sickness	33.5	GSR, APOA1, APOL1, HPR, TXN, SRM
2	malaria	27.7	IL10, IL1A, IL4, IFNG, IFNGR2, GNAS
3	encephalitis	23.5	PIK3CG, SELE, VCAM1, MYD88, BMP6, JUN
4	chagas disease	19.7	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
5	leishmaniasis	18.8	RELA, MYD88, BMP6, JUN, FOS, IRAK1
6	cerebral cavernous malformations 3	13.9	PPP2R1A, PPP2R2D, PPP2R2A, PPP2R2C, PPP2CB, PPP2CA
7	pseudohypoparathyroidism	13.8	GNA11, GNA15, GNAL, GNAS, HP, ADCY1
8	fainting	13.7	SERPINE1, GNA11, GNA14, GNA15, GNAI1, GNAI2
9	transient cerebral ischemia	13.5	JUN, FOS, GSR, IDO1, AMD1, ODC1
10	splenomegaly	13.5	IL10, FASLG, FAS, GPT, CASP8, HP
11	coccidioidomycosis	13.5	IL10, IL12A, IFNG, IFNGR1, TLR4
12	relapsing-remitting multiple sclerosis	13.4	IL10, IL18, IL1RN, CCL5, IFNB1, IFNG
13	cblc	13.4	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
14	salivary gland cancer	13.4	CHUK, CFLAR, FAS, CASP8, AKT1, AKT3
15	african tick-bite fever	13.4	SELE, IL10, CCL3, CCL5, GPT, IFNG
16	invasive aspergillosis	13.4	IFNG, HBB, TLR4, TLR6, CXCL10, CSF3
17	tick-borne encephalitis	13.4	GSR, CCL2, CCL3, GPT, IGHV4-39, IFNB1
18	cryptosporidiosis	13.3	IL1A, IL4, CCL5, CXCL10, CSF3
19	miliary tuberculosis	13.3	IL10, IL18, IFNG, ALB, CSF3, ADA
20	beta thalassemia	13.3	GSR, GPT, ALB, HP, HBA1, HBA2
21	oral cavity cancer	13.3	IL18, IL4, FADD, MAPK14, CASP8, TLR2
22	plasmodium falciparum malaria	13.3	SELE, GSR, IL10, IL18, IFNG, ICAM1
23	coronary arteriosclerosis	13.3	SELE, IL6, APOA1, CCL2, CCL5, TF
24	japanese encephalitis	13.2	JUN, IL4, FADD, MAPK14, IGHV4-39, CASP8
25	burkitt's lymphoma	13.2	BMP6, CFLAR, IL4, FASLG, FAS, CCL3
26	b-cell lymphomas	13.2	CHUK, CFLAR, FAS, MAPK3, MAPK14, CASP8
27	spotted fever	13.1	IL10, CCL5, IGHV4-39, IFNG, IDO1, TNF
28	pleural tuberculosis	13.1	IL18, IL4, IFNG, TNF, ADA
29	extrinsic allergic alveolitis	13.1	IL8, CCL2, CCL3, CCL5, TNFRSF1A, TGFB2
30	chronic mucocutaneous candidiasis	13.1	IL10, IL2, IL4, IFNB1, IFNG, STAT1
31	multinodular goiter	13.1	GSR, IL1A, IL1B, IFNG, GNAS, TGFB2
32	hypersensitivity reaction type iv disease	13.0	SELE, IL2, IL4, IFNG, ICAM1, TF
33	omenn syndrome	13.0	IL10, IL1RN, IL4, IFNG, IFNGR1, TNF
34	lepromatous leprosy	13.0	IL10, IL2, IL4, IFNG, TLR2
35	herpes zoster	13.0	IL10, IL4, IGHV4-39, IFNG, HP, TNF
36	meningococcemia	13.0	SERPINE1, IL1A, IL1B, IL1RN, CCL5
37	primary systemic mycosis	13.0	IL10, IL4, IGHV4-39, TNF
38	scleritis	13.0	IL4, CCL2, IFNG, TNF, TNFRSF1B
39	brain cancer	13.0	PIK3CA, PIK3CG, BDKRB2, FASLG, MAPK8, MAPK9
40	glioblastoma	12.9	PIK3CA, PIK3CG, FASLG, MAPK8, IFNB1, CASP8
41	multifocal motor neuropathy	12.9	IL10, IL2, IL4, IFNG
42	campylobacteriosis	12.9	JUN, IL1B, IFNG, TLR4, STAT1
43	pulmonary tuberculosis	12.9	CD247, IL10, IL12B, IL18, IL2, IL4
44	poliomyelitis	12.9	IL10, IL4, IGHV4-39, IFNG, ICAM1, TNF
45	viral meningitis	12.9	IL6, IL8, CCL5, CXCL10, ADA
46	extrapulmonary tuberculosis	12.9	IL10, IL1A, IL1B, IL1RN, CCL2, IFNG
47	chronic lymphocytic leukemia	12.9	CFLAR, IL2, IL4, CASP8, TXN, TNFRSF13C
48	guillain-barre syndrome	12.9	IL10, FAS, IFNG, HP, TNF, TNFRSF1A
49	cytomegalovirus retinitis	12.9	IL2, FASLG, IFNB1, IFNG, IDO1, TNF
50	cutaneous t cell lymphoma	12.9	SELE, IL2, IL4, FAS, IFNG, TGFBR1

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 pentamidine, pentamidine isethionate

MalaCards organs/tissues related to trypanosomiasis:

²²

MGI Mouse Phenotypes related to trypanosomiasis:

²⁵ (show all 25)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system phenotype	MP:0005397	10.6	MYD88, BDKRB2, CHUK, LAMA4, CFLAR, CD3D
2	respiratory system phenotype	MP:0005388	10.5	IL12A, IL12B, GNA11, GNAQ, CRH, ADA
3	renal/urinary system phenotype	MP:0005367	10.3	MYD88, BDKRB2, CHUK, MAPK9, IFNGR1, F2RL1
4	craniofacial phenotype	MP:0005382	9.9	IL12B, MAPK8, MAPK9, GNA11, GNAQ, GNAS
5	no phenotypic analysis	MP:0003012	9.7	PIK3CD, PIK3R1, VCAM1, MYD88, FADD, MAPK13
6	endocrine/exocrine gland phenotype	MP:0005379	9.7	BDKRB2, IL2, FASLG, IFNG, GNA11, GNAI2
7	embryogenesis phenotype	MP:0005380	9.5	PIK3CB, PIK3CA, CHUK, CFLAR, CD247, FOS
8	liver/biliary system phenotype	MP:0005370	9.0	IL2, IL6, APOA1, MAP2K4, MAPK11, MAPK9
9	digestive/alimentary phenotype	MP:0005381	8.9	BDKRB2, IL12B, IL18, MAPK8, MAPK11, MAPK9
10	integument phenotype	MP:0010771	8.7	PIK3CG, RELA, CHUK, FOS, IL4, FASLG
11	immune system phenotype	MP:0005387	8.0	PIK3CD, PIK3R5, MYD88, BDKRB2, CHUK, CFLAR
12	skeleton phenotype	MP:0005390	8.0	PIK3CD, PIK3CG, RELA, MYD88, BMP6, BDKRB2
13	nervous system phenotype	MP:0003631	7.8	RELA, MYD88, CHUK, LAMA4, CD3E, CD247
14	normal phenotype	MP:0002873	7.6	PIK3R1, RELA, SELE, BDKRB2, JUN, FOS
15	adipose tissue phenotype	MP:0005375	6.8	PIK3CA, PIK3R1, SERPINE1, MYD88, BDKRB2, IL18
16	reproductive system phenotype	MP:0005389	6.7	PIK3CA, BDKRB2, CHUK, FOS, IL10, IL1RN
17	vision/eye phenotype	MP:0005391	6.4	PIK3CA, RELA, SELE, MYD88, CHUK, JUN
18	mortality/aging	MP:0010768	6.2	PIK3CB, PIK3CA, RELA, SELE, SERPINE1, VCAM1
19	muscle phenotype	MP:0005369	5.9	PIK3CA, PIK3R2, PIK3R1, PIK3CG, RELA, LAMA4
20	tumorigenesis	MP:0002006	4.7	PIK3CB, PIK3CA, PIK3R2, PIK3R1, SERPINE1, MYD88
21	growth/size phenotype	MP:0005378	4.6	PIK3CB, PIK3CA, PIK3R1, PIK3CG, RELA, SELE
22	behavior/neurological phenotype	MP:0005386	4.2	PIK3CA, SELE, MYD88, BDKRB2, LAMA4, JUN
23	homeostasis/metabolism phenotype	MP:0005376	3.9	PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, PIK3CG
24	cellular phenotype	MP:0005384	3.4	PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3R5, PIK3CG
25	cardiovascular system phenotype	MP:0005385	2.9	PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, PIK3CG

Articles related to trypanosomiasis:

(show all 24)

id	Title	Authors	Year	Affiliating Genes
1	Novel S-adenosylmethionine decarboxylase inhibitors for the treatment of human African trypanosomiasis. (19289530)	Barker R.H.... Sybertz E.	2009	AMD1
2	Discovery of new S-adenosylmethionine decarboxylase i nhibitors for the treatment of Human African Trypanosomiasis (HAT). (19419862)	Hirth B.... Xiang Y.	2009	AMD1
3	Expression and role of CXCL10 during the encephalitic stage of experimental and clinical African trypanosomiasis. (19827943)	Amin D.N.... Masocha W.	2009	CXCL10
4	A combined CXCL10, CXCL8 and H-FABP panel for the sta ging of human African trypanosomiasis patients. (19554086)	Hainard A.... Sanchez J.C.	2009	CCL2, IFNG, IL10
5	Trypanosomiasis-induced B cell apoptosis results in loss of protective anti-parasite antibody responses and abolishment of vaccine-induced memory responses. (18516300)	Radwanska M.... Magez S.	2008	TNFRSF13C
6	The anti-oxidant defence response in individuals with the indeterminate form of Chagas disease (American trypanosomiasis). (18348773)	PAcrez-Fuentes R.... SA!nchez-GuillAcn M.C.	2008	SOD1
7	Combination chemotherapy with a substance P receptor antagonist (aprepitant) and melarsoprol in a mouse model of human African trypanosomiasis. (17643344)	Rodgers J.... Kennedy P.G.	2007	TACR1
8	Association between human African trypanosomiasis and the IL6 gene in a Congolese population. (16720107)	Courtin D.... Garcia A.	2007	TNF, IL6, IL8
9	Experimental therapy of African trypanosomiasis with a nanobody-conjugated human trypanolytic factor. (16604085)	Baral T.N.... De Baetselier P.	2006	APOL1
10	Harbouring in the brain: A focus on immune evasion mechanisms and their deleterious effects in malaria and human African trypanosomiasis. (16600243)	Bisser S.... Mazier D.	2006	IL10
11	Interest of tumor necrosis factor-alpha -308 G/A and interleukin-10 -592 C/A polymorphisms in human African trypanosomiasis. (15894515)	Courtin D.... Garcia A.	2006	TNF, IL10
12	Haptoglobin phenotype appears to affect the pathogenesis of American trypanosomiasis. (16630378)	Calderoni D.R.... Grotto H.Z.	2006	HP
13	Treatment of African trypanosomiasis with cordycepin and adenosine deaminase inhibitors in a mouse model. (16206083)	Rottenberg M.E.... Wigzell H.	2005	ADA
14	Antibodies directed against nitrosylated neoepitopes in sera of patients with human African trypanosomiasis. (15482403)	Semballa S.... Vincendeau P.	2004	ALB
15	P75 tumor necrosis factor-receptor shedding occurs as a protective host response during African trypanosomiasis. (14745712)	Magez S.... De Baetselier P.	2004	TNFRSF1B
16	Severity of human african trypanosomiasis in East Afr ica is associated with geographic location, parasite genotype, and host inflamm atory cytokine response profile. (15557627)	MacLean L.... Sternberg J.M.	2004	BMP6
17	Glycosylinositolphosphate soluble variant surface glycoprotein inhibits IFN-gamma-induced nitric oxide production via reduction in STAT1 phosphorylation in African trypanosomiasis. (12874239)	Coller S.P.... Paulnock D.M.	2003	STAT1
18	Perspectives for new drugs against trypanosomiasis and leishmaniasis. (11966468)	Barrett M.P.... Gilbert I.H.	2002	PGD
19	Importance of L-tryptophan metabolism in trypanosomiasis. (10721096)	Vincendeau P.... Costa C.V.	1999	IFNG, IDO1
20	Trypanosoma brucei brucei: a long-term model of human African trypanosomiasis in mice, meningo-encephalitis, astrocytosis, and neurological disorders. (9030668)	Keita M.... Dumas M.	1997	GFAP
21	Blood levels of protein markers of inflammation and nutrition in the meningo-encephalitis phase of human African trypanosomiasis (9289245)	Monnet D.... Yapo A.E.	1997	TF
22	Contribution of biochemical tests in the diagnosis of the nervous phase of human African trypanosomiasis (9507761)	Bisser S.... Breton J.C.	1997	TF, ALB, GPT
23	Impairment of adrenocortical function associated with increased plasma tumor necrosis factor-alpha and interleukin-6 concentrations in African trypanosomiasis. (8528879)	Reincke M.... Chrousos G.P.	1994	CRH
24	Towards more efficacious chemotherapy of trypanosomiasis: combination of alpha-difluoromethylornithine (DFMO) with reactive oxygen generating drugs. (1787820)	Eze M.O.	1991	ODC1

Genes related to trypanosomiasis according to GeneCards:

(show top 50)    (show all 151)

id	Symbol	Description	Score	GeneCards Section Context
1	APOL1	apolipoprotein L, 1	11.0	Pathways & Interactions, Publications
2	SRM	spermidine synthase	11.0
3	HPR	haptoglobin-related protein	11.0	Pathways & Interactions
4	TICAM1	toll-like receptor adaptor molecule 1	11.0	Pathways & Interactions
5	PGD	phosphogluconate dehydrogenase	11.0	Publications
6	PREP	prolyl endopeptidase	11.0
7	ODC1	ornithine decarboxylase 1	11.0	Publications
8	TACR1	tachykinin receptor 1	11.0	Publications
9	TXN	thioredoxin	11.0
10	TF	transferrin	11.0	Publications
11	ARHGAP15	Rho GTPase activating protein 15	11.0
12	GAPDH	glyceraldehyde-3-phosphate dehydrogenase	11.0
13	APOA1	apolipoprotein A-I	11.0	Pathways & Interactions
14	GSR	glutathione reductase	11.0
15	IGHV4-39	immunoglobulin heavy variable 4-39	10.9
16	CCL3L3	chemokine (C-C motif) ligand 3-like 3	10.9	Pathways & Interactions
17	PPP2R2D	protein phosphatase 2, regulatory subunit B, delta	10.9	Pathways & Interactions
18	CCL3L1	chemokine (C-C motif) ligand 3-like 1	10.9	Pathways & Interactions
19	C1QC	complement component 1, q subcomponent, C chain	10.9	Pathways & Interactions
20	C1QB	complement component 1, q subcomponent, B chain	10.9	Pathways & Interactions
21	CD3G	CD3g molecule, gamma (CD3-TCR complex)	10.9	Pathways & Interactions
22	HBD	hemoglobin, delta	10.9	Pathways & Interactions
23	CD3D	CD3d molecule, delta (CD3-TCR complex)	10.9	Pathways & Interactions
24	C1QA	complement component 1, q subcomponent, A chain	10.9	Pathways & Interactions
25	TNFRSF13C	tumor necrosis factor receptor superfamily, member 13C	10.9	Publications
26	THOP1	thimet oligopeptidase 1	10.9	Pathways & Interactions
27	PLCB3	phospholipase C, beta 3 (phosphatidylinositol-specific)	10.9	Pathways & Interactions
28	PLCB2	phospholipase C, beta 2	10.9	Pathways & Interactions
29	AMD1	adenosylmethionine decarboxylase 1	10.9	Publications
30	PPP2CB	protein phosphatase 2, catalytic subunit, beta isozyme	10.9	Pathways & Interactions
31	MAPK13	mitogen-activated protein kinase 13	10.9	Pathways & Interactions
32	GNA15	guanine nucleotide binding protein (G protein), alpha 15 (Gq class)	10.9	Pathways & Interactions
33	PIK3R2	phosphoinositide-3-kinase, regulatory subunit 2 (beta)	10.9	Pathways & Interactions
34	GNA11	guanine nucleotide binding protein (G protein), alpha 11 (Gq class)	10.9	Pathways & Interactions
35	IFNGR2	interferon gamma receptor 2 (interferon gamma transducer 1)	10.9	Pathways & Interactions
36	MAPK12	mitogen-activated protein kinase 12	10.9	Pathways & Interactions
37	GNAI3	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	10.9	Pathways & Interactions
38	CD3E	CD3e molecule, epsilon (CD3-TCR complex)	10.9	Pathways & Interactions
39	MYD88	myeloid differentiation primary response gene (88)	10.9	Pathways & Interactions
40	IL12A	interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)	10.9	Pathways & Interactions
41	IRAK1	interleukin-1 receptor-associated kinase 1	10.9	Pathways & Interactions
42	IRAK4	interleukin-1 receptor-associated kinase 4	10.9	Pathways & Interactions
43	LAMA4	laminin, alpha 4	10.9	Pathways & Interactions
44	IFNGR1	interferon gamma receptor 1	10.9	Pathways & Interactions
45	IDO1	indoleamine 2,3-dioxygenase 1	10.9	Publications, Pathways & Interactions
46	IDO2	indoleamine 2,3-dioxygenase 2	10.9	Pathways & Interactions
47	IL12B	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)	10.9	Pathways & Interactions
48	HBA2	hemoglobin, alpha 2	10.9	Pathways & Interactions
49	IKBKG	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma	10.9	Pathways & Interactions
50	HBA1	hemoglobin, alpha 1	10.9	Pathways & Interactions

Pathways related to trypanosomiasis according to GeneDecks:

(show top 50)    (show all 583)

id	Pathway	Score	Top Affiliating Genes
1	Apoptosis and survival Anti-apoptotic action of membrane-bound ESR110	10.7	MAPK9, PIK3R2, PIK3CD
2	Pancreatic cancer20	10.6	PIK3R5, PIK3R2, PIK3R3, IKBKG, AKT2, AKT3
3	CTLA4 Signaling36	10.2	PPP2R2C, PPP2R2A, PPP2R1A, PPP2R2B, AKT3, AKT2
4	Immune response_ICOS pathway in T-helper cell41	10.2	PIK3CG, PIK3CA, PIK3CD, PIK3CB, CD3D, CD3G
5	Tight junction20	10.2	PPP2R2D, PPP2R1A, PPP2R2B, AKT3, AKT2, AKT1
6	Immune response IL-9 signaling pathway10	10.1	STAT1, NFKBIA, NFKB1, TNFRSF1A, IKBKB, MAPK3
7	Apoptosis and survival APRIL and BAFF signaling10	10.1	RELA, CHUK, NFKBIA, NFKB1, TNFRSF13C, TRAF6
8	Renal cell carcinoma20	10.0	TGFB3, AKT3, AKT2, MAPK3, JUN, PIK3R5
9	CD27 Pathway36	9.8	IKBKB, MAPK9, MAPK10, MAP2K4, MAPK8, FOS
10	WNT Signaling36	9.7	GNAI1, GNA15, GNA14, GNA11, MAPK9, MAPK10
11	Development_Leptin signaling via PI3K-dependent pathway41	9.7	NFKBIA, NFKB1, AKT3, AKT2, AKT1, IKBKB
12	Immune response IL-23 signaling pathway10	9.7	PIK3CD, PIK3CB, PIK3CA, PIK3R3, PIK3R2, STAT1
13	PKC-Theta Pathway36	9.6	PIK3R2, PIK3R3, PIK3R1, GNAL, IKBKG, IKBKB
14	Signal transduction_Erk Interactions- Inhibition of Erk41	9.6	AKT1, MAPK9, MAPK1, MAPK10, MAPK3, MAPK8
15	Thrombin Signaling36	9.6	GNAI1, GNA15, GNA14, GNA11, IKBKB, MAPK11
16	Development_A3 receptor signaling41	9.6	GNAI2, GNAI1, GNA11, IKBKB, MAPK3, CHUK
17	Thrombopoietin Pathway36	9.5	PIK3R3, PIK3R2, PRKCA, PRKCG, STAT1, MAPK1
18	TNFR1 Pathway36	9.5	NFKBIA, NFKB1, TNFRSF1A, TNF, CASP8, IKBKG
19	Development PDGF signaling via STATs and NF-kB10	9.4	CHUK, RELA, PIK3R1, PIK3R2, PIK3R3, PIK3CA
20	Immune response_IL-12-induced IFN-gamma production41	9.4	NFKB1, NOS2, TRAF6, IFNG, IKBKB, MAPK9
21	Translation _Regulation of EIF4F activity41	9.4	MAP2K4, MAPK12, PIK3R1, PIK3R2, PIK3R3, PIK3CA
22	fMLP Pathway36	9.3	PRKCA, MAPK1, MAPK3, PIK3R1, PIK3R2, PIK3R3
23	Leukocyte transendothelial migration20	9.3	PIK3CB, GNAI1, ICAM1, MAPK11, MAPK14, MAPK13
24	Immune response_CD28 signaling41	9.2	CD3E, CD3G, CD3D, JUN, CHUK, RELA
25	Development_A1 receptor signaling41	9.2	ADCY1, PRKCA, NFKBIA, NFKB1, PLCB3, AKT3
26	G-AlphaQ Signaling36	9.2	PLCB1, PLCB4, PLCB2, AKT3, AKT2, AKT1
27	PKR Pathway36	9.2	JUN, CHUK, RELA, FOS, PPP2R2B, IFNGR1
28	Endometrial cancer20	9.2	AKT2, AKT1, MAPK1, MAPK3, PIK3CG, PIK3R5
29	Development Neurotrophin family signaling10	9.1	MAPK8, JUN, PIK3R1, PIK3R2, PIK3R3, PIK3CA
30	Insulin signaling pathway20	9.1	PIK3CB, AKT3, AKT2, IKBKB, MAPK1, MAPK10
31	Development Thrombopoietin-regulated cell processes10	9.0	PRKCA, AKT3, AKT2, AKT1, MAPK1, MAPK3
32	Development HGF signaling pathway10	8.9	PIK3R1, PIK3R2, PIK3R3, PIK3CA, PIK3CD, PIK3CB
33	Immune response IL-22 signaling pathway10	8.9	MAPK8, IL2, IL12B, IL12A, FOS, JUN
34	IL-10 Pathway36	8.9	TLR4, NFKB1, TNF, MAPK11, MAPK14, MAPK13
35	Immune response_IL-9 signaling pathway41	8.8	STAT1, NFKBIA, NFKB1, TNFRSF1A, TNF, IKBKB
36	CXCR4 Pathway36	8.7	GNAI1, PIK3R3, PIK3R2, GNA15, GNA14, GNA11
37	Development_Thrombopoietin-regulated cell processes41	8.6	PIK3CD, PIK3CB, PIK3CA, PIK3R3, PIK3R2, PRKCA
38	PPAR Pathway36	8.5	TGFBR1, TGFB3, TGFB2, PIK3R3, TNFRSF1B, TNFRSF1A
39	ErbB signaling pathway20	8.3	PRKCA, PIK3R2, PIK3R3, PIK3CA, PIK3CD, PIK3CB
40	Neurotrophin signaling pathway20	8.3	NFKBIA, NFKB1, TRAF6, AKT3, AKT2, AKT1
41	14-3-3 Induced Intracellular Signaling36	8.2	PRKCA, MAPK14, MAPK3, MAPK13, MAP2K4, MAPK12
42	IL-2 Pathway36	8.2	MAP2K4, MAPK12, MAPK8, IL2, FOS, JUN
43	Cholinergic synapse20	7.8	PRKCB, PRKCG, PLCB3, PLCB1, PLCB4, PLCB2
44	Cytokine Network36	7.7	TNF, IFNG, IFNB1, IL8, IL6, IL4
45	14-3-3 Induced Apoptosis36	7.7	TLR4, NFKBIA, NFKB1, TNFRSF1A, TNF, FADD
46	NF-KappaB (p50-p65) Pathway36	7.5	IKBKG, IKBKB, FADD, IL6, IL2, IL1B
47	all-trans-Retinoic Acid Signaling in Brain36	7.3	CCL5, CCL3, CCL3L1, CCL2, IL8, IL6
48	MAPK signaling pathway20	6.9	PRKCA, PRKCB, PRKCG, TGFBR2, TGFBR1, MAPK10
49	MAPK Signaling36	5.7	TGFB2, TGFB1, NFKB1, PLCB3, PLCB1, PLCB4
50	Antioxidant Action of Vitamin-C36	4.7	IL4, IL2, IL1B, IL1A, IL18, IL12B

Compounds related to trypanosomiasis according to GeneDecks:

(show top 50)    (show all 356)

id	Compound	Score	Top Affiliating Genes
1	glucose32	10.7	CHUK, CFLAR, MAP2K4, IKBKB, IKBKG, GNAI1
2	nadph32 18	11.5	PIK3CA, MYD88, BDKRB2, AKT1, PGD
3	l-nmma32	10.1	VCAM1, BDKRB2, IL1RN, CRH, NOS2, TACR1
4	ionomycin32	10.0	PIK3CB, CHUK, FOS, MAPK3, CCL3, CALR
5	n acetylcysteine32	9.4	SELE, VCAM1, CHUK, FOS, IL18, MAPK10
6	dopamine32 9 18 9	12.2	PIK3CA, SELE, BMP6, FOS, FAS, IFNB1
7	atorvastatin32 34 9 18 9	13.2	SELE, VCAM1, BMP6, IL10, IL18, IL1RN
8	pge232	9.2	SELE, VCAM1, BDKRB2, GSR, IL1A, IL1RN
9	sulfasalazine32 9 9	11.2	SELE, CHUK, IL12B, IL1A, IL1B, IL1RN
10	estrogen32	9.2	PIK3CB, PIK3R1, SERPINE1, GSR, IL18, IL1RN
11	c2ceramide32	9.0	PIK3CG, CHUK, JUN, IL1B, MAPK8, MAPK14
12	chloroquine32 34 9 9	11.9	BMP6, GSR, IL10, IL18, IL1RN, IL2
13	ribavirin32 34 9 9	11.8	IL10, IL18, IL2, IL4, CCL3, GPT
14	ceramide32	8.8	PIK3CA, PIK3R1, MAP2K4, MAPK3, MAPK14, MAPK10
15	gf 109203x32 42	9.7	PIK3CB, PIK3CG, JUN, FOS, MAPK8, MAPK3
16	calcitriol32 42 9 18 9	12.6	PIK3CB, BMP6, JUN, FOS, IL2, CCL5
17	glutamine32	8.6	PIK3CG, BMP6, IL18, IL1A, FADD, FAS
18	flagellin32	8.6	MYD88, IRAK1, IL18, IL1B, IL8, IFNB1
19	4-hydroxynonenal32 18	9.5	CHUK, JUN, FOS, GSR, IL10, FAS
20	tamoxifen32 34 9 9	11.4	PIK3CA, SELE, VCAM1, BMP6, CHUK, JUN
21	helenalin32	8.4	PIK3CG, VCAM1, CHUK, JUN, IL1B, IL6
22	calcium32 9 18 9	11.4	PIK3CD, RELA, BDKRB2, CFLAR, CD247, FOS
23	peptidoglycan32	8.3	PIK3CA, MYD88, CHUK, IRAK1, IL10, IL12B
24	infliximab32 9 9	10.3	SELE, IL10, IL18, IL1B, IL1RN, IL4
25	norepinephrine32 9 18 9	11.2	SELE, VCAM1, BMP6, IL18, IL1A, IL1RN
26	rottlerin32 42	9.1	PIK3R1, PIK3CG, VCAM1, JUN, IL8, MAPK8
27	imiquimod32 42 9 9	11.1	BMP6, IL10, IL12B, IL18, IL1A, IL6
28	okt332	8.1	SELE, VCAM1, BMP6, IL10, IL2, IL4
29	thapsigargin32 42	9.0	PIK3CG, SERPINE1, BDKRB2, IL2, IL4, MAPK8
30	arsenite32 18	8.7	PIK3CA, PIK3R1, PIK3CG, CHUK, CFLAR, JUN
31	rosiglitazone32 9 18 9	10.4	PIK3CA, PIK3CG, SELE, SERPINE1, VCAM1, JUN
32	mg 13232 42	8.4	PIK3CG, CFLAR, JUN, IL1A, IL1B, IL8
33	methotrexate32 34 42 9 9	11.4	SELE, SERPINE1, BMP6, GSR, IL10, IL18
34	hydrocortisone32 9 9	9.1	BMP6, IL10, IL1A, IL1B, IL1RN, IL2
35	butyrate32	7.0	BMP6, JUN, FOS, IL18, IL8, FASLG
36	pentoxifylline32 9 9	8.9	VCAM1, BMP6, IL10, IL12B, IL18, IL1A
37	ciglitazone32	6.9	SERPINE1, JUN, IL1B, IL6, IL8, MAPK14
38	superoxide32 18	7.8	PIK3CA, PIK3R1, VCAM1, CHUK, GSR, IL1B
39	rantes32	6.6	SELE, VCAM1, MYD88, BMP6, CHUK, JUN
40	simvastatin32 34 42 9 18 9	11.6	SELE, SERPINE1, VCAM1, BMP6, CHUK, IL10
41	cholesterol32 9 18 9	9.5	PIK3CB, PIK3CA, PIK3R1, SELE, SERPINE1, VCAM1
42	fmlp32	6.4	PIK3CG, VCAM1, IL1A, IL1B, IL1RN, IL8
43	lactate32	6.3	PIK3CA, SELE, VCAM1, BMP6, GSR, IL18
44	lipid32	5.7	PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3CG, SELE
45	thymidine32 18	6.4	PIK3CA, PIK3R1, BMP6, CFLAR, JUN, FOS
46	nitric oxide32 9 18 9	8.2	PIK3CB, SELE, VCAM1, MYD88, BMP6, BDKRB2
47	retinoic acid32 42 18	6.7	PIK3CA, PIK3CG, SERPINE1, VCAM1, BMP6, CHUK
48	herbimycin a32 42	5.7	PIK3CG, SELE, VCAM1, BMP6, JUN, FOS
49	pd 98,05932	4.3	PIK3CA, PIK3R1, PIK3CG, SERPINE1, VCAM1, BMP6
50	genistein32 9 18 9	7.1	PIK3CA, PIK3R1, PIK3CG, SELE, SERPINE1, VCAM1

Cellular components related to trypanosomiasis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	alpha-beta T cell receptor complex	GO:042105	10.2	CD3E, CD3G, CD3D, CD247
2	protein phosphatase type 2A complex	GO:000159	10.1	PPP2CA, PPP2CB, PPP2R2C, PPP2R2A, PPP2R2D, PPP2R1A
3	death-inducing signaling complex	GO:031264	10.1	CASP8, FAS, FADD, CFLAR
4	membrane raft	GO:045121	9.4	PRKCA, TLR4, TNFRSF1B, TNFRSF1A, TNF, CASP8
5	external side of plasma membrane	GO:009897	8.5	TNFRSF13C, ACE, TLR2, TLR4, TGFBR2, CXCL10
6	plasma membrane	GO:005886	6.9	TNFRSF1B, PPP2CA, SMAD3, PLCB2, NFKBIA, TNFRSF1A
7	cytosol	GO:005829	6.1	PLCB3, ADA, GAPDH, PGD, SOD1, PRKCA
8	extracellular region	GO:005576	6.0	C1QC, C1QA, CRH, TNFRSF1B, TNFRSF1A, TXN
9	extracellular space	GO:005615	4.4	SELE, SERPINE1, VCAM1, BMP6, IL10, IL12A

Biological processes related to trypanosomiasis according to GeneDecks:

(show top 50)    (show all 103)

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of tumor necrosis factor production	GO:032760	10.4	CCL3, MYD88, TLR4, IL12B, TICAM1, FADD
2	JNK cascade	GO:007254	10.1	IRAK1, MYD88, IRAK4, MAPK8, MAP2K4, MAPK10
3	positive regulation of type I interferon production	GO:032481	10.0	CHUK, NFKB1, RELA, IKBKB, TICAM1, IKBKG
4	T cell receptor signaling pathway	GO:050852	10.0	CHUK, RELA, PIK3R1, PIK3R2, PIK3CA, PIK3CD
5	T cell costimulation	GO:031295	9.9	CD3E, CD3G, PIK3R1, PIK3CA, CD3D, PIK3R3
6	response to virus	GO:009615	9.8	IKBKG, IFNG, IL12A, IKBKB, CHUK, IFNB1
7	positive regulation of inflammatory response	GO:050729	9.7	IL12B, TLR9, PRKCA, IL2, IL18, MAPK13
8	induction of apoptosis by extracellular signals	GO:008624	9.7	CFLAR, CD3E, CASP8, PRKCA, TICAM1, TNFRSF1A
9	response to lipopolysaccharide	GO:032496	9.6	CXCL10, IRAK1, SELE, FAS, TNFRSF1A, CASP8
10	positive regulation of T cell proliferation	GO:042102	9.6	VCAM1, IL6, TRAF6, IL1B, IL12B, IL12A
11	positive regulation of smooth muscle cell proliferation	GO:048661	9.5	JUN, STAT1, PRKCA, TRAF6, TNF, CCL5
12	stress-activated MAPK cascade	GO:051403	9.4	TRAF6, FOS, JUN, IRAK1, MAPK8, IKBKG
13	positive regulation of I-kappaB kinase/NF-kappaB cascade	GO:043123	9.4	PRKCB, TICAM1, TLR9, TLR6, TLR4, TNFRSF1A
14	positive regulation of nitric oxide biosynthetic process	GO:045429	9.4	TICAM1, IL1B, IFNG, ICAM1, AKT1, TNF
15	regulation of sequence-specific DNA binding transcription factor activity	GO:051090	9.4	MAPK9, MAPK14, MAPK1, MAPK11, JUN, MAPK10
16	cellular response to mechanical stimulus	GO:071260	9.4	MAPK8, NFKB1, TNFRSF1A, CASP8, MAPK3, MYD88
17	positive regulation of interleukin-6 production	GO:032755	9.3	MYD88, IL1A, IL1B, IL6, MAPK13, TNF
18	fibroblast growth factor receptor signaling pathway	GO:008543	9.2	ADCY1, PRKCA, PPP2CB, PRKCG, AKT1, PPP2R1A
19	aging	GO:007568	9.2	IL1B, C1QB, TGFB1, TGFB2, VCAM1, TGFB3
20	activation of MAPK activity	GO:000187	9.1	TRAF6, MAPK10, IRAK1, MAPK14, MAPK11, MAPK1
21	MyD88-independent toll-like receptor signaling pathway	GO:002756	9.1	MAPK14, MAPK10, MAPK11, MAPK1, MAPK9, IKBKB
22	protein kinase B signaling cascade	GO:043491	9.0	TNF, CCL5, AKT1, TGFB1, CCL2, PIK3CA
23	lipopolysaccharide-mediated signaling pathway	GO:031663	9.0	CCL2, MAPK14, MAPK3, IL1B, IL18, IRAK1
24	toll-like receptor 3 signaling pathway	GO:034138	9.0	TLR4, MAPK3, MAP2K4, MAPK8, IRAK1, FOS
25	TRIF-dependent toll-like receptor signaling pathway	GO:035666	9.0	TRAF6, IRAK1, FOS, JUN, CHUK, RELA
26	nerve growth factor receptor signaling pathway	GO:048011	8.9	NFKB1, TRAF6, AKT1, IKBKB, MAPK1, MAPK11
27	induction of apoptosis	GO:006917	8.9	STAT1, FASLG, TNF, PPP2R1A, IFNB1, MAPK1
28	toll-like receptor 4 signaling pathway	GO:034142	8.9	TICAM1, TLR6, TLR4, TLR2, NFKBIA, NFKB1
29	MAPK cascade	GO:000165	8.9	MAPK1, MAPK12, MAPK3, CCL2, IL1B, IL18
30	Toll signaling pathway	GO:008063	8.9	TLR2, NFKBIA, NFKB1, TRAF6, IKBKG, IKBKB
31	toll-like receptor 2 signaling pathway	GO:034134	8.9	TLR6, TLR4, TLR2, MAP2K4, MAPK8, IRAK4
32	toll-like receptor 1 signaling pathway	GO:034130	8.9	TLR6, MAPK10, MAPK14, MAPK3, MAP2K4, MAPK8
33	cellular response to lipopolysaccharide	GO:071222	8.9	TLR4, NOS2, TNFRSF1B, ICAM1, IFNG, CCL2
34	toll-like receptor signaling pathway	GO:002224	8.8	RELA, NFKBIA, TLR2, TLR4, TLR6, NFKB1
35	MyD88-dependent toll-like receptor signaling pathway	GO:002755	8.8	RELA, MYD88, CHUK, JUN, FOS, IRAK1
36	positive regulation of interferon-gamma production	GO:032729	8.8	IL12B, TNF, IL2, IL12A, CD3E, TLR4
37	neutrophil chemotaxis	GO:030593	8.8	PRKCA, CCL3, TGFB2, PIK3CD, PIK3CG, IL1B
38	cytokine-mediated signaling pathway	GO:019221	8.7	IFNGR2, IFNG, IFNB1, CCL2, MAPK3, IL6
39	innate immune response	GO:045087	8.5	MAPK10, CHUK, MYD88, RELA, PIK3CG, PIK3CD
40	positive regulation of NF-kappaB transcription factor activity	GO:051092	8.5	PRKCB, TGFB1, TICAM1, TLR9, TLR4, TLR2
41	response to drug	GO:042493	8.5	TGFBR2, CALR, TGFB2, GNAO1, TGFB1, IFNG
42	response to hypoxia	GO:001666	8.3	TNFRSF1A, SMAD3, TNF, CCL2, FAS, IL1A
43	immune response	GO:006955	8.2	C1QC, TLR2, CCL3L3, FASLG, IL8, CXCL10
44	anti-apoptosis	GO:006916	8.2	IKBKB, PIK3CA, RELA, CFLAR, IRAK1, IL10
45	apoptotic process	GO:006915	7.5	IFNG, NFKBIA, TGFBR1, TGFBR2, PRKCB, PRKCA
46	platelet activation	GO:030168	7.3	PRKCA, GNAI1, GNA15, GNA14, GNA11, ALB
47	signal transduction	GO:007165	7.3	PIK3CB, PIK3CD, MYD88, IRAK1, IL1B, TXN
48	blood coagulation	GO:007596	7.2	SOD1, PIK3R1, PIK3R5, PIK3CG, SERPINE1, APOA1
49	positive regulation of transcription from RNA polymerase II promoter	GO:045944	6.8	TLR9, TLR4, TLR2, NFKBIA, NFKB1, SMAD3
50	inflammatory response	GO:006954	6.6	BMP6, TNFRSF1A, TNFRSF1B, CRH, NFKB1, TLR2

Molecular functions related to trypanosomiasis according to GeneDecks:

(show all 13)

id	Name	GO ID	Score	Top Affiliating Genes
1	1-phosphatidylinositol-3-kinase activity	GO:016303	10.1	PIK3CG, PIK3R2, PIK3R3, PIK3CA, PIK3CD, PIK3CB
2	phosphatidylinositol phospholipase C activity	GO:004435	10.1	PLCB1, PLCB4, PLCB2, CCL5, BDKRB2, PLCB3
3	protein heterodimerization activity	GO:046982	10.0	PPP2R1A, TLR2, TLR6, TGFB1, TGFB2, TGFB3
4	transmembrane signaling receptor activity	GO:004888	10.0	TLR6, TLR4, TLR2, ICAM1, CD247, CD3E
5	MAP kinase activity	GO:004707	10.0	MAPK1, MAPK11, MAPK14, MAPK3, MAPK13, MAPK12
6	phosphatidylinositol-4,5-bisphosphate 3-kinase activity	GO:046934	9.8	PIK3CG, PIK3CA, PIK3CD, PIK3CB
7	interleukin-1 receptor binding	GO:005149	9.8	TLR9, IL1RN, IL1B, IL1A, IRAK4
8	protein kinase activity	GO:004672	9.8	PRKCA, PRKCG, TGFBR1, AKT3, AKT1, IKBKB
9	phosphatidylinositol 3-kinase activity	GO:035004	9.6	PIK3CG, PIK3CA, PIK3CD, PIK3CB
10	protein serine/threonine kinase activity	GO:004674	9.0	MAPK1, IKBKB, AKT1, AKT2, AKT3, TGFBR1
11	growth factor activity	GO:008083	8.3	IL6, TGFB1, TGFB2, TGFB3, CSF3, IL4
12	cytokine activity	GO:005125	8.0	IL6, FASLG, IFNB1, IFNG, TNF, TGFB2
13	protein binding	GO:005515	2.5	GNAI2, PPP2R1A, PPP2R2A, PPP2CB, PPP2CA, PPP2R1B