MCID: TRY001
MIFTS: 51

Trypanosomiasis malady

Categories: Infectious diseases

Aliases & Classifications for Trypanosomiasis

Aliases & Descriptions for Trypanosomiasis:

Name: Trypanosomiasis 12 52 42 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:10113
ICD10 33 B57.2
ICD9CM 35 086 086.9
MeSH 42 D014352
UMLS 69 C0041227

Summaries for Trypanosomiasis

Disease Ontology : 12 A parasitic protozoa infectious disease that involves infection caused by parasitic protozoan of the genus Trypanosoma in animals and humans.

MalaCards based summary : Trypanosomiasis is related to loiasis and tuberculosis. An important gene associated with Trypanosomiasis is APOL1 (Apolipoprotein L1), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Carvedilol and Enalapril have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and t cells, and related phenotypes are cellular and hematopoietic system

Wikipedia : 71 Trypanosomiasis or trypanosomosis is the name of several diseases in vertebrates caused by parasitic... more...

Related Diseases for Trypanosomiasis

Diseases related to Trypanosomiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 362)
id Related Disease Score Top Affiliating Genes
1 loiasis 29.8 IFNG IL10 IL4
2 tuberculosis 29.6 CCL2 IL10 IL1B IL2 IL4 IL6
3 sleeping sickness 12.1
4 chagas disease 11.9
5 trypanosomiasis, human east-african 11.8
6 trypanosomiasis, human west-african 11.8
7 intussusception 10.4 IL1B TNF
8 pyridoxal 5'-phosphate-dependent epilepsy 10.4 IL10 TNF
9 transient tic disorder 10.4 IL10 IL6 TNF
10 stocco dos santos syndrome 10.4 IFNG IL1B TNF
11 tarsal tunnel syndrome 10.4 IDO1 IL10 TNF
12 lepromatous leprosy 10.4 IFNG IL10 IL6
13 chronic apical periodontitis 10.4 IDO1 IL10 TNF
14 multiple mitochondrial dysfunctions syndrome 10.4 IFNG IL10 IL6
15 neonatal hypoxic and ischemic brain injury 10.4 CXCL8 IL10 IL6
16 anal paget's disease 10.4 IL1B IL6 TNF
17 bipolar i disorder 10.4 IL1B IL6 TNF
18 primary ciliary dyskinesia 10.3 IL10 IL6 TNF
19 human immunodeficiency virus infectious disease 10.3 IL1B IL6 TNF
20 measles 10.3 IL1B IL6 TNF
21 oculomotor nerve paralysis 10.3 CXCL8 IL1B IL6
22 dextrocardia 10.3 IL1B IL6 TNF
23 common peroneal nerve lesion 10.3 CXCL8 IL1B IL6
24 congenital dyserythropoietic anemia 10.3 ALB TNF
25 megaloblastic anemia 10.3 IDO1 IL10 IL1B
26 benign neonatal seizures 10.3 IL1B IL6 TNF
27 urea cycle disorder 10.3 IL10 IL1B IL6
28 schwannoma of ureter 10.3 CCL2 CXCL8 IL6
29 cicatricial lagophthalmos 10.3 CXCL8 IL6 TNF
30 usher syndrome, type 2a 10.3 IFNG IL10 IL6
31 immunodeficiency due to a late component of complement deficiency 10.3 CXCL8 IFNG IL10
32 bullous retinoschisis 10.3 CXCL8 IL1B IL6
33 carbuncle 10.3 CXCL8 IL1B IL6
34 keratoconus 10.3 IL1B IL6 TNF
35 splenic artery aneurysm 10.3 IL1B IL6 TNF
36 conduct disorder 10.3 IFNG IL10 IL6 TNF
37 pancreatic signet ring cell adenocarcinoma 10.3 IFNG IL10 IL6 TNF
38 myoglobinuria recurrent 10.3 IFNG IL4
39 orthostatic proteinuria 10.3 CXCL8 IL6 TNF
40 disease of mental health 10.3 IFNG IL10 IL6 TNF
41 follicular adenoma 10.3 IFNG IL10 IL6 TNF
42 lateral cystocele 10.3 CCL2 CXCL8 IL6
43 ciliary discoordination, due to random ciliary orientation 10.3 ALB IFNG IL10
44 phlyctenulosis 10.3 IDO1 IL10 IL6 TNF
45 rickettsialpox 10.3 IFNG IL10 IL1B TNF
46 tubular renal disease-cardiomyopathy syndrome 10.3 IL10 IL4 TNF
47 hypoparathyroidism-retardation-dysmorphism syndrome 10.3 IL10 IL1B IL6 TNF
48 rheumatoid factor-negative juvenile idiopathic arthritis without anti-nuclear antibodies 10.3 IL10 IL1B IL6 TNF
49 asymptomatic neurosyphilis 10.3 IFNG IL10 IL4
50 pancreas lymphoma 10.3 IL1B IL6 TNF

Graphical network of the top 20 diseases related to Trypanosomiasis:



Diseases related to Trypanosomiasis

Symptoms & Phenotypes for Trypanosomiasis

MGI Mouse Phenotypes related to Trypanosomiasis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.06 ALB CALR HP IDO1 IFNG IL10
2 hematopoietic system MP:0005397 10 CCL5 HP IDO1 IFNG IL10 IL1B
3 immune system MP:0005387 9.9 CCL2 CCL5 HP IDO1 IFNG IL10
4 liver/biliary system MP:0005370 9.56 HP IFNG IL10 IL2 IL4 IL6
5 neoplasm MP:0002006 9.23 ALB HP IFNG IL10 IL1B IL2

Drugs & Therapeutics for Trypanosomiasis

Drugs for Trypanosomiasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 72)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Carvedilol Approved, Investigational Phase 4 72956-09-3 2585
2
Enalapril Approved, Vet_approved Phase 4 75847-73-3 5362032 40466924
3
Enalaprilat Approved Phase 4 76420-72-9 6917719
4
Warfarin Approved Phase 4 81-81-2 6691 54678486
5
Aspirin Approved, Vet_approved Phase 4 50-78-2 2244
6 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1
7 Antiparasitic Agents Phase 4,Phase 3,Phase 2,Phase 1
8 Antiprotozoal Agents Phase 4,Phase 3,Phase 2,Phase 1
9 Benzonidazole Phase 4,Phase 3,Phase 2
10 Immunosuppressive Agents Phase 4,Phase 3,Phase 2
11 Nifurtimox Phase 4,Phase 3,Phase 2,Phase 1
12 Adrenergic Agents Phase 4,Phase 3
13 Adrenergic alpha-1 Receptor Antagonists Phase 4
14 Adrenergic alpha-Antagonists Phase 4
15 Adrenergic Antagonists Phase 4,Phase 3
16 Adrenergic beta-Antagonists Phase 4,Phase 3
17 Angiotensin-Converting Enzyme Inhibitors Phase 4
18 Antihypertensive Agents Phase 4,Phase 3
19 HIV Protease Inhibitors Phase 4
20 Natriuretic Peptide, Brain Phase 4
21 Neurotransmitter Agents Phase 4,Phase 3
22
protease inhibitors Phase 4
23 Vasodilator Agents Phase 4
24 Anticoagulants Phase 4
25 Peripheral Nervous System Agents Phase 4,Phase 3
26 Analgesics Phase 4
27 Analgesics, Non-Narcotic Phase 4
28 Anti-Inflammatory Agents Phase 4
29 Anti-Inflammatory Agents, Non-Steroidal Phase 4
30 Antipyretics Phase 4
31 Antirheumatic Agents Phase 4
32 Cyclooxygenase Inhibitors Phase 4
33 Fibrinolytic Agents Phase 4
34 Platelet Aggregation Inhibitors Phase 4
35
Ornithine Nutraceutical Phase 4,Phase 3,Phase 2 3184-13-2 6262 389
36
Coumarin Nutraceutical Phase 4 91-64-5 323
37
Bisoprolol Approved Phase 3 66722-44-9 2405
38
Selenium Approved, Vet_approved Phase 3 7782-49-2
39
Coal tar Approved Phase 3 8007-45-2
40 Adrenergic beta-1 Receptor Antagonists Phase 3
41 Autonomic Agents Phase 3
42 Sympatholytics Phase 3
43 Antioxidants Phase 3
44 Micronutrients Phase 3
45 Protective Agents Phase 3
46 Sodium Selenite Phase 3
47 Trace Elements Phase 3
48 Melarsoprol Phase 3
49
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
50
Pentamidine Approved Phase 2 100-33-4 4735

Interventional clinical trials:

(show top 50) (show all 67)
id Name Status NCT ID Phase
1 Optimization of PCR Technique to Assess Parasitological Response for Patients With Chronic Chagas Disease Unknown status NCT01678599 Phase 4
2 Population Pharmacokinetics Study of Benznidazole in Children With Chagas'Disease Unknown status NCT01549236 Phase 4
3 Clinical Study to Assess the Tolerability, Feasibility and Effectiveness of Nifurtimox and Eflornithine (NECT) for the Treatment of Trypanosoma Brucei Gambiense Human African Trypanosomiasis (HAT) in the Meningo-encephalitic Phase Completed NCT00906880 Phase 4
4 Population Pharmacokinetics in Benznidazole-treated Adults With Chronic With Chagas Disease Completed NCT01755403 Phase 4
5 Exercise Training in Chagas Cardiomyopathy Completed NCT01006473 Phase 4
6 A Randomized Trial of Carvedilol in Chronic Chagas Cardiomyopathy Completed NCT01557140 Phase 4
7 Outcomes of an Anticoagulation Clinic in an University Hospital Completed NCT01006486 Phase 4
8 Clinical Assessment, Neuroimaging and Immunomarkers in Chagas Disease Study (CLINICS) Recruiting NCT01650792 Phase 4
9 Reveal Chagas: Clinical Evidence of the Implantable Cardiac Monitor in Patients With Chagas Disease Terminated NCT01539161 Phase 4
10 BENEFIT: Evaluation of the Use of Antiparasital Drug (Benznidazole) in the Treatment of Chronic Chagas' Disease Unknown status NCT00123916 Phase 3
11 Efficacy - Safety of Eflornithine-Nifurtimox Combination Versus Eflornithine to Treat Human African Trypanosomiasis Completed NCT00146627 Phase 3
12 Rapid Diagnostic Tests and Clinical/Laboratory Predictors of Tropical Diseases in Neurological Disorders in DRC Completed NCT01589289 Phase 3
13 Etiologic Treatment With Benznidazole in Adult Patients With Chronic Chagas Disease. A Randomized Clinical Trial Completed NCT02386358 Phase 3
14 Cardiac Rehabilitation in Chagas Heart Failure Completed NCT02516293 Phase 2, Phase 3
15 Chagas Cardiomyopathy Bisoprolol Intervention Study: Charity Completed NCT00323973 Phase 3
16 Prospective Study on Efficacy and Safety of SCYX-7158 in Patients Infected by Human African Trypanosomiasis Due to T.b. Gambiense Recruiting NCT03087955 Phase 2, Phase 3
17 Fexinidazole in Human African Trypanosomiasis Due to T.b. Gambiense at Any Stage Recruiting NCT03025789 Phase 3
18 CHICAMOCHA 3 - Equivalence of Usual Interventions for Trypanosomiasis (EQUITY) Recruiting NCT02369978 Phase 2, Phase 3
19 Prospective Study of a Pediatric Nifurtimox Formulation for Chagas' Disease Recruiting NCT02625974 Phase 3
20 Selenium Treatment and Chagasic Cardiopathy (STCC) Recruiting NCT00875173 Phase 3
21 Pivotal Study of Fexinidazole for Human African Trypanosomiasis in Stage 2 Active, not recruiting NCT01685827 Phase 2, Phase 3
22 Efficacy and Safety of Fexinidazole in Patients With Stage 1 or Early Stage 2 Human African Trypanosomiasis (HAT) Due to T.b. Gambiense: a Prospective, Multicentre, Open-label Cohort Study, plug-in to the Pivotal Study Active, not recruiting NCT02169557 Phase 2, Phase 3
23 Efficacy and Safety of Fexinidazole in Children at Least 6 Years Old and Weighing Over 20 kg With Human African Trypanosomiasis (HAT) Due to T.b. Gambiense: a Prospective, Multicentre, Open Study, plug-in to the Pivotal Study Active, not recruiting NCT02184689 Phase 2, Phase 3
24 Physical Exercise Program in Chronic Chagas Heart Disease Active, not recruiting NCT02517632 Phase 3
25 Eflornithine + Nifurtimox Late-Stage Human African Trypanosomiasis (HAT)in West Nile, Uganda Terminated NCT00489658 Phase 2, Phase 3
26 Randomized Clinical Trial of Three Drug Combinations for Late-Stage Gambiense Human African Trypanosomiasis Terminated NCT00330148 Phase 3
27 Cell Therapy in Chagas Cardiomyopathy Terminated NCT00349271 Phase 3
28 Proof-of-Concept Study of E1224 to Treat Adult Patients With Chagas Disease Unknown status NCT01489228 Phase 2
29 Trial of DB289 for the Treatment of Stage I African Trypanosomiasis Completed NCT00803933 Phase 2
30 A Trial of DB289 for the Treatment of Stage I African Trypanosomiasis Completed NCT00802594 Phase 2
31 A Study of the Use of Oral Posaconazole (POS) in the Treatment of Asymptomatic Chronic Chagas Disease (P05267) Completed NCT01377480 Phase 2
32 Clinical Trial For The Treatment Of Chronic Chagas Disease With Posaconazole And Benznidazole Completed NCT01162967 Phase 2
33 Study to Evaluate Fexinidazole Dosing Regimens for the Treatment of Adult Patients With Chagas Disease Recruiting NCT02498782 Phase 2
34 Evaluation of G-CSF (Colony Stimulating Factor) in Patients With Chronic Chagas Cardiomyopathy Enrolling by invitation NCT02154269 Phase 2
35 Human African Trypanosomiasis: First in Man Clinical Trial of a New Medicinal Product, the Fexinidazole Completed NCT00982904 Phase 1
36 Human African Trypanosomiasis: First in Man Clinical Trial of a New Medicinal Product, the SCYX-7158 Completed NCT01533961 Phase 1
37 Bioequivalence Study - Reference Clinical Fexinidazole Tablet Versus Proposed Market Formulation Completed NCT02571062 Phase 1
38 Fexinidazole (1200mg) Bioavailability Under Different Food Intake Conditions Completed NCT01340157 Phase 1
39 Study to Assess the Food Effect on the Pharmacokinetics of Nifurtimox Tablets in Chronic Chagas' Patients Completed NCT02606864 Phase 1
40 Study to Assess Bioequivalence of 30 and 120 mg Nifurtimox Tablets in Chronic Chagas' Patients Completed NCT01927224 Phase 1
41 Multiple Dose Study to Evaluate Security, Tolerance and Pharmacokinetic of Fexinidazole (Drug Candidate for Human African Trypanosomiasis) Administered With a Loading Dose and With Food Terminated NCT01483170 Phase 1
42 Prevalence of Chagas Disease in Immigrant Patients With Conduction Abnormalities on Electrocardiogram Unknown status NCT00453700
43 Exercise Training in Patients With Chagasic Heart Disease Without Ventricular Dysfunction Unknown status NCT02295215
44 Renal Denervation in Patients With Heart Failure Secondary to Chagas Disease Unknown status NCT02099903
45 Improving Blood Safety and HIV Testing in Brazil Unknown status NCT01681420
46 Rapid Diagnostic Tests and Clinical/Laboratory Predictors of Tropical Diseases In Patients With Persistent Fever in Cambodia, Nepal, Democratic Republic of the Congo and Sudan (NIDIAG-Fever) Completed NCT01766830
47 Abbott ESA Chagas Assay Post-Market Study Completed NCT01662362
48 Assessment of Speckle Tracking Strain Predictive Value for Myocardial Fibrosis in Chagas Disease Completed NCT02327052
49 MicroRNAs as Biomarkers in Patients With Chagas Disease Completed NCT01842880
50 Syndecan-4 as a Biomarker in Patients With Chagas Disease Completed NCT01842867

Search NIH Clinical Center for Trypanosomiasis

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: trypanosomiasis

Genetic Tests for Trypanosomiasis

Anatomical Context for Trypanosomiasis

MalaCards organs/tissues related to Trypanosomiasis:

39
Testes, Brain, T Cells, Heart, Endothelial, Myeloid, B Cells

Publications for Trypanosomiasis

Articles related to Trypanosomiasis:

(show top 50) (show all 620)
id Title Authors Year
1
Erratum: Discovery of a Carbazole-Derived Lead Drug for Human African Trypanosomiasis. ( 28074881 )
2017
2
An overlooked horticultural crop, Smyrnium olusatrum, as a potential source of compounds effective against African trypanosomiasis. ( 28087440 )
2017
3
Combatting African Animal Trypanosomiasis (AAT) in livestock: The potential role of trypanotolerance. ( 27369574 )
2016
4
African Trypanosomiasis. ( 27974038 )
2016
5
WC-9 a Lead Drug with Great Prospects for American Trypanosomiasis and Toxoplasmosis. ( 27290911 )
2016
6
Human Leukocyte Antigen-G: A Promising Prognostic Marker of Disease Progression to Improve the Control of Human African Trypanosomiasis. ( 27470243 )
2016
7
Human African Trypanosomiasis in the Kafue National Park, Zambia. ( 27196336 )
2016
8
Human African Trypanosomiasis Encephalitis in the United States: Serial Magnetic Resonance Imaging. ( 27695600 )
2016
9
Kynurenine Pathway Activation in Human African Trypanosomiasis. ( 28013248 )
2016
10
Characteristics, behaviors and association between Human African Trypanosomiasis and HIV seropositivity among volunteer blood donors in a semi-rural area: A survey from Kikwit, the Democratic Republic of Congo. ( 27787206 )
2016
11
Factors Influencing Passive Surveillance for T. b. rhodesiense Human African Trypanosomiasis in Uganda. ( 27212706 )
2016
12
Beyond Tsetse - Implications for Research and Control of Human African Trypanosomiasis Epidemics. ( 26826783 )
2016
13
Congenital Trypanosomiasis in Child Born in France to African Mother. ( 27088460 )
2016
14
The Inhibition of Cysteine Proteases Rhodesain and TbCatB: a Valuable Approach to Treat Human African Trypanosomiasis. ( 27156518 )
2016
15
Forecasting Human African Trypanosomiasis Prevalences from Population Screening Data Using Continuous Time Models. ( 27657937 )
2016
16
Food and pathogen adaptations in the Angolan Namib desert: Tracing the spread of lactase persistence and human African trypanosomiasis resistance into southwestern Africa. ( 27402285 )
2016
17
Evaluation of Antigens for Development of a Serological Test for Human African Trypanosomiasis. ( 27936225 )
2016
18
Assessment of animal African trypanosomiasis (AAT) vulnerability in cattle-owning communities of sub-Saharan Africa. ( 26825496 )
2016
19
Urea Derivatives of 2-Aryl-benzothiazol-5-amines: A New Class of Potential Drugs for Human African Trypanosomiasis. ( 27992217 )
2016
20
Anterior uveitis as the first sign of human African trypanosomiasis: a case report. ( 27694095 )
2016
21
Comparative evaluation of the nested ITS PCR against the 18S PCR-RFLP in a survey of bovine trypanosomiasis in Kwale County, Kenya. ( 27423733 )
2016
22
Animal African Trypanosomiasis: Time to Increase Focus on Clinically Relevant Parasite and Host Species. ( 27167665 )
2016
23
Neemazal Ar as a possible alternative control tool for malaria and African trypanosomiasis? ( 27146309 )
2016
24
PREVALENCE OF AMERICAN TRYPANOSOMIASIS AND LEISHMANIASES IN DOMESTIC DOGS IN A RURAL AREA OF THE MUNICIPALITY OF SA8O JOA8O DO PIAUA8, PIAUA8 STATE, BRAZIL. ( 27828620 )
2016
25
Human Trypanosomiasis in the Eastern Plains of Colombia: New Transmission Scenario. ( 26728765 )
2016
26
Metabolomics Identifies Multiple Candidate Biomarkers to Diagnose and Stage Human African Trypanosomiasis. ( 27941966 )
2016
27
A Multi-Host Agent-Based Model for a Zoonotic, Vector-Borne Disease. A Case Study on Trypanosomiasis in Eastern Province, Zambia. ( 28027323 )
2016
28
Bioluminescence Imaging to Detect Late Stage Infection of African Trypanosomiasis. ( 27284970 )
2016
29
Computer-Aided Drug Discovery Approaches against the Tropical Infectious Diseases Malaria, Tuberculosis, Trypanosomiasis, and Leishmaniasis. ( 27622945 )
2016
30
Past and Ongoing Tsetse and Animal Trypanosomiasis Control Operations in Five African Countries: A Systematic Review. ( 28027299 )
2016
31
Tsetse Flies (Glossina) as Vectors of Human African Trypanosomiasis: A Review. ( 27034944 )
2016
32
Discovery of a Carbazole-Derived Lead Drug for Human African Trypanosomiasis. ( 27561392 )
2016
33
The relationship of endotoxaemia to peripheral and central nervous system inflammatory responses in Human African Trypanosomiasis. ( 27894360 )
2016
34
Impact of mass chemotherapy in domestic livestock for control of zoonotic T. b. rhodesiense human African trypanosomiasis in Eastern Uganda. ( 27570206 )
2016
35
Human African trypanosomiasis diagnosis by peripheral blood smear review in a Spanish traveler. ( 27127825 )
2016
36
Co-infection with Plasmodium berghei and Trypanosoma brucei increases severity of malaria and trypanosomiasis in mice. ( 27021269 )
2016
37
Bug Smash, Bug Splash: A Case Report of an Unusual Transmission of American Trypanosomiasis with a Brief Review of the Literature. ( 28031550 )
2016
38
Host Intracellular Signaling Events and Pro-inflammatory Cytokine Production in African Trypanosomiasis. ( 27242788 )
2016
39
Performance of Microscopy for the Diagnosis of Malaria and Human African Trypanosomiasis by Diagnostic Laboratories in the Democratic Republic of the Congo: Results of a Nation-Wide External Quality Assessment. ( 26788725 )
2016
40
Prevalence of tuberculosis, brucellosis and trypanosomiasis in cattle in Tanzania: a systematic review and meta-analysis. ( 27427190 )
2016
41
Revisiting zoonotic human African trypanosomiasis control in Uganda. ( 26779716 )
2016
42
Recent Updates on Development of Drug Molecules for Human African Trypanosomiasis. ( 27072715 )
2016
43
Knowledge and prevalence of Human African Trypanosomiasis among residents of Kachia grazing reserve, Kachia local government area, Kaduna state, Nigeria, 2012. ( 27222686 )
2016
44
Editorial (Thematic Issue: Therapeutic Interventions Against Trypanosomiasis). ( 27297226 )
2016
45
West African Trypanosomiasis with Central Nervous System Involvement. ( 27582522 )
2016
46
Determinants of Human African Trypanosomiasis Elimination via Paratransgenesis. ( 26954675 )
2016
47
Stakeholder Narratives on Trypanosomiasis, Their Effect on Policy and the Scope for One Health. ( 26658646 )
2015
48
Human African trypanosomiasis in non-endemic countries. ( 25650203 )
2015
49
Mathematical models of human african trypanosomiasis epidemiology. ( 25765194 )
2015
50
Preventing the transmission of American trypanosomiasis and its spread into non-endemic countries. ( 26715535 )
2015

Variations for Trypanosomiasis

Expression for Trypanosomiasis

Search GEO for disease gene expression data for Trypanosomiasis.

Pathways for Trypanosomiasis

Pathways related to Trypanosomiasis according to GeneCards Suite gene sharing:

(show top 50) (show all 77)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
14.14 CALR CCL2 CCL3 CCL5 CXCL8 HP
2
Show member pathways
13.79 CCL2 CCL3 CCL5 CXCL8 IFNG IL10
3
Show member pathways
13.67 CCL2 CCL3 CCL5 CXCL8 IFNG IL10
4
Show member pathways
13.54 CCL2 CCL3 CCL5 CXCL8 IL10 IL1B
5
Show member pathways
13.49 CCL2 CCL3 CCL5 CXCL8 IFNG IL10
6
Show member pathways
13.44 CCL2 CCL3 CCL5 CXCL8 IL10 IL1B
7
Show member pathways
13.06 CCL2 CCL5 CXCL8 IL1B IL6 TNF
8
Show member pathways
13.03 CALR CCL2 CCL3 CCL5 CXCL8 IFNG
9
Show member pathways
12.98 CALR CXCL8 IFNG IL10 IL1B IL2
10
Show member pathways
12.92 CCL2 CCL5 CXCL8 IFNG IL1B IL2
11
Show member pathways
12.85 CCL5 CXCL8 IFNG IL1B IL6 TNF
12
Show member pathways
12.75 IFNG IL10 IL1B IL2 IL4 IL6
13
Show member pathways
12.74 CCL2 IFNG IL10 IL1B IL2 IL6
14
Show member pathways
12.71 IFNG IL10 IL2 IL4 TNF
15 12.67 CCL2 CCL5 IDO1 IFNG IL10 IL1B
16
Show member pathways
12.59 IFNG IL10 IL1B IL2 IL4 IL6
17
Show member pathways
12.49 CCL2 CXCL8 IFNG IL1B IL4 IL6
18
Show member pathways
12.44 ALB CCL2 CCL5 IFNG IL1B IL2
19
Show member pathways
12.41 CXCL8 IFNG IL1B IL6 TNF
20
Show member pathways
12.4 IFNG IL10 IL1B IL4 TNF
21 12.37 IFNG IL10 IL1B IL6 TNF
22
Show member pathways
12.36 IFNG IL10 IL2 IL4 IL6
23
Show member pathways
12.34 CXCL8 IFNG IL1B IL4 IL6 TNF
24 12.33 CXCL8 IL10 IL1B IL6 TF TNF
25
Show member pathways
12.29 CXCL8 IFNG IL10 IL1B IL2 IL4
26 12.19 CCL2 IFNG IL1B TNF
27 12.17 IFNG IL10 IL2 IL4 IL6 TNF
28
Show member pathways
12.14 CCL3 IFNG IL1B IL2 IL4
29 12.14 CCL2 CXCL8 IL10 IL1B IL4 IL6
30
Show member pathways
12.13 CCL2 CCL3 CCL5 CXCL8
31 12.12 CCL2 CCL5 IL1B IL6 TNF
32 12.11 CCL3 CXCL8 IFNG IL1B IL6
33
Show member pathways
12.11 IFNG IL10 IL1B IL2 IL6 TNF
34 12.11 CCL2 CXCL8 IFNG IL1B IL2 IL4
35
Show member pathways
12.1 ALB APOL1 CALR HP HPR
36 12.07 CCL2 CXCL8 IL1B IL6 TNF
37
Show member pathways
12.05 IFNG IL1B IL4 IL6
38 12.05 CXCL8 IFNG IL10 IL1B IL6 TNF
39 12.02 IL1B IL4 IL6 TNF
40 12 CCL3 CXCL8 IFNG IL1B IL6
41 11.97 CXCL8 IFNG IL2 IL4 IL6
42 11.94 CCL3 IFNG IL10 IL1B IL2 IL4
43
Show member pathways
11.93 CXCL8 IFNG IL2 IL4 TNF
44 11.93 CXCL8 IL10 IL1B IL6 TNF
45 11.92 IFNG IL10 IL1B IL2 IL6 TNF
46 11.92 CCL2 CCL3 CCL5 CXCL8 IFNG IL1B
47 11.87 IL10 IL4 IL6 TNF
48 11.84 IFNG IL10 IL2 IL6
49
Show member pathways
11.82 CXCL8 IFNG IL1B IL2 IL6 TNF
50 11.75 CXCL8 IL1B IL6 TNF

GO Terms for Trypanosomiasis

Cellular components related to Trypanosomiasis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.89 ALB APOL1 CALR CCL2 CCL3 CCL5
2 endoplasmic reticulum lumen GO:0005788 9.72 ALB APOL1 CALR IL6 TF
3 external side of plasma membrane GO:0009897 9.65 CALR IFNG IL4 IL6 TNF
4 blood microparticle GO:0072562 9.55 ALB APOL1 HP HPR TF
5 extracellular space GO:0005615 9.53 ALB APOL1 CALR CCL2 CCL3 CCL5

Biological processes related to Trypanosomiasis according to GeneCards Suite gene sharing:

(show top 50) (show all 80)
id Name GO ID Score Top Affiliating Genes
1 response to virus GO:0009615 9.99 CCL5 IFNG ODC1 TNF
2 cellular calcium ion homeostasis GO:0006874 9.98 CALR CCL2 CCL3 CCL5
3 response to glucocorticoid GO:0051384 9.96 CCL2 IL10 IL6 TNF
4 chemokine-mediated signaling pathway GO:0070098 9.96 CCL2 CCL3 CCL5 CXCL8
5 cellular response to tumor necrosis factor GO:0071356 9.95 CCL2 CCL3 CCL5 CXCL8 IL6
6 regulation of insulin secretion GO:0050796 9.94 CCL5 IFNG IL1B TNF
7 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.93 IL10 IL1B IL4 IL6 TNF
8 cellular response to lipopolysaccharide GO:0071222 9.93 CCL2 CXCL8 IFNG IL10 IL6 TNF
9 cell chemotaxis GO:0060326 9.92 CCL2 CCL3 CCL5
10 response to cytokine GO:0034097 9.92 CCL5 IL4 IL6
11 cellular response to interleukin-1 GO:0071347 9.92 CCL2 CCL3 CCL5 CXCL8 IL6
12 cellular response to interferon-gamma GO:0071346 9.91 CCL2 CCL3 CCL5
13 positive regulation of smooth muscle cell proliferation GO:0048661 9.91 CCL5 IL6 TNF
14 humoral immune response GO:0006959 9.91 CCL2 IFNG IL6 TNF
15 cellular response to organic cyclic compound GO:0071407 9.91 CCL2 CCL3 CCL5 IL1B TNF
16 positive regulation of tumor necrosis factor production GO:0032760 9.9 CCL2 CCL3 IFNG
17 positive regulation of cell adhesion GO:0045785 9.9 CCL2 CCL5 IFNG TNF
18 positive regulation of interferon-gamma production GO:0032729 9.89 IL1B IL2 TNF
19 positive regulation of interleukin-6 production GO:0032755 9.89 IL1B IL6 TNF
20 positive regulation of nitric oxide biosynthetic process GO:0045429 9.88 IFNG IL1B IL6 TNF
21 cellular response to estradiol stimulus GO:0071392 9.87 CCL2 IL10 IL6
22 cellular response to fibroblast growth factor stimulus GO:0044344 9.86 CCL2 CCL5 CXCL8
23 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.86 IL1B IL2 IL4
24 monocyte chemotaxis GO:0002548 9.86 CCL2 CCL3 CCL5 IL6
25 positive regulation of phagocytosis GO:0050766 9.85 CALR IL1B TNF
26 negative regulation of growth of symbiont in host GO:0044130 9.83 IFNG IL10 TNF
27 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.83 CCL5 IFNG IL2 IL4 IL6
28 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.82 IFNG IL1B TNF
29 macrophage chemotaxis GO:0048246 9.8 CCL2 CCL3 CCL5
30 defense response to protozoan GO:0042832 9.8 IFNG IL10 IL4 IL6
31 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.78 IL10 IL1B TNF
32 positive regulation of isotype switching to IgG isotypes GO:0048304 9.77 IFNG IL2 IL4
33 protein kinase B signaling GO:0043491 9.77 CCL2 CCL3 CCL5 IL1B TNF
34 negative regulation of lipid storage GO:0010888 9.75 IL6 TNF
35 polyamine metabolic process GO:0006595 9.75 AMD1 ODC1
36 neutrophil activation GO:0042119 9.75 CCL5 CXCL8
37 eosinophil chemotaxis GO:0048245 9.75 CCL3 CCL5
38 positive regulation of interleukin-6 biosynthetic process GO:0045410 9.75 IFNG IL1B
39 endothelial cell apoptotic process GO:0072577 9.74 IL10 TNF
40 negative regulation of T cell apoptotic process GO:0070233 9.74 CCL5 IDO1
41 regulation of defense response to virus by host GO:0050691 9.74 IFNG IL1B
42 positive regulation of T cell apoptotic process GO:0070234 9.74 CCL5 IDO1
43 positive regulation of MHC class II biosynthetic process GO:0045348 9.74 IFNG IL10 IL4
44 regulation of establishment of endothelial barrier GO:1903140 9.73 IL1B TNF
45 negative regulation of cytokine secretion involved in immune response GO:0002740 9.73 IL10 TNF
46 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.73 IL6 TNF
47 astrocyte cell migration GO:0043615 9.73 CCL2 CCL3
48 type 2 immune response GO:0042092 9.73 IL10 IL4
49 neutrophil chemotaxis GO:0030593 9.73 CCL2 CCL3 CCL5 CXCL8 IFNG IL1B
50 positive regulation of natural killer cell chemotaxis GO:2000503 9.72 CCL3 CCL5

Molecular functions related to Trypanosomiasis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.62 IL10 IL2 IL4 IL6
2 phospholipase activator activity GO:0016004 9.4 CCL3 CCL5
3 CCR5 chemokine receptor binding GO:0031730 9.37 CCL3 CCL5
4 cytokine activity GO:0005125 9.36 CCL2 CCL3 CCL5 CXCL8 IFNG IL10
5 CCR1 chemokine receptor binding GO:0031726 9.26 CCL3 CCL5
6 chemokine activity GO:0008009 9.26 CCL2 CCL3 CCL5 CXCL8
7 hemoglobin binding GO:0030492 9.16 HP HPR

Sources for Trypanosomiasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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