MCID: TRY001
MIFTS: 50

Trypanosomiasis malady

Summaries for Trypanosomiasis

About this section
Sources:
8Disease Ontology, 63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Disease Ontology:8 A parasitic protozoa infectious disease that involves infection caused by parasitic protozoan of the genus trypanosoma in animals and humans.

MalaCards: Trypanosomiasis is related to sleeping sickness and chagas disease. An important gene associated with Trypanosomiasis is APOL1 (apolipoprotein L, 1), and among its related pathways are African trypanosomiasis and PEDF Induced Signaling. The drugs pentamidine and pentamidine isethionate and the compounds aspartate and ascorbic acid have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and t cells.

Wikipedia:63 Trypanosomiasis or trypanosomosis is the name of several diseases in vertebrates caused by parasitic... more...

Aliases & Classifications for Trypanosomiasis

About this section
Sources:
8Disease Ontology, 44Novoseek, 60UMLS, 27ICD9CM, 56SNOMED-CT, 34MeSH
See all sources

Aliases & Descriptions:

trypanosomiasis 8 44 60


External Ids:

Disease Ontology8 DOID:10113
ICD9CM27 086, 086.9
MeSH34 D014352

Related Diseases for Trypanosomiasis

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Trypanosomiasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 79)
idRelated DiseaseScoreTop Affiliating Genes
1sleeping sickness31.1SRM, HPR, APOL1, ODC1
2chagas disease31.0ODC1, GAPDH, SRM, GSR
3leishmaniasis30.8PGD, SRM
4malaria30.6ODC1, GAPDH, HPR, SRM, GSR
5tuberculosis29.8GAPDH, HPR, GSR
6cerebritis10.1
7amebiasis10.1
8encephalitis10.1
9trypanosomiasis, human east-african10.1
10babesiosis10.1
11trichinosis10.1
12louping ill10.1
13schistosomiasis10.1
14toxoplasmosis10.1
15trypanosomiasis, human west-african10.1
16deficiency anemia10.0TXN, GAPDH, TF, HPR, PGD, GSR
17schizophrenia10.0ODC1, APOL1, GAPDH, PREP, TACR1, GSR
18diabetes mellitus10.0TXN, APOA1, GAPDH, TF, HPR, GSR
19alzheimer's disease10.0GSR, TACR1, PREP, GAPDH, TXN
20vascular disease10.0TXN, GAPDH, TF, HPR, GSR
21rheumatoid arthritis10.0TXN, TNFRSF13C, APOA1, TACR1
22arthritis10.0TACR1, HPR, TXN
23hepatitis b10.0GSR, APOA1, TXN
24asthma10.0GAPDH, TACR1, GSR
25leukemia10.0GAPDH, ODC1
26multiple sclerosis10.0GSR, APOA1, TNFRSF13C
27glucosephosphate dehydrogenase deficiency10.0GSR, HPR
28cataract10.0TXN, GAPDH, GSR
29osteoarthritis10.0TACR1, GSR
30acute myocardial infarction10.0TXN, APOA1, GSR
31hepatocellular carcinoma10.0TF, GAPDH, TXN
32sarcoma10.0ODC1, GAPDH
33pneumonia10.0TXN
34breast cancer10.0ODC1, TXN, GAPDH, HPR, GSR
35glioblastoma multiforme10.0TACR1, GAPDH, ODC1
36atherosclerosis10.0APOA1, TXN
37influenza10.0TXN
38adenocarcinoma10.0ODC1, GAPDH, TACR1
39psoriasis10.0ODC1, TACR1
40ischemia10.0GSR
41infertility10.0GAPDH
42hepatitis10.0TXN, TF, GSR
43hyperglycemia10.0TXN
44cholera10.0TF, ODC1
45pancreatitis10.0TACR1
46galactosemia10.0HPR, TF
47coronary heart disease10.0APOA1, GSR
48fatty liver disease10.0TF, APOA1, TXN
49malignant glioma10.0ODC1, CCL3L1, PREP, TACR1, GSR
50acute pancreatitis10.0TACR1

Graphical network of the top 20 diseases related to Trypanosomiasis:



Diseases related to trypanosomiasis

Clinical Features for Trypanosomiasis

About this section

Drugs & Therapeutics for Trypanosomiasis

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Trypanosomiasis

Drug clinical trials:

Search ClinicalTrials for Trypanosomiasis

Search NIH Clinical Center for Trypanosomiasis

Search CenterWatch for Trypanosomiasis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Trypanosomiasis

About this section

Anatomical Context for Trypanosomiasis

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Trypanosomiasis:

32
Testes, Brain, T cells, Heart, Skin, Myeloid, B cells, Endothelial

Animal Models for Trypanosomiasis or affiliated genes

About this section

Publications for Trypanosomiasis

About this section
Sources:
50PubMed
See all sources

Articles related to Trypanosomiasis:

(show top 50)    (show all 527)
idTitleAuthorsYear
1
Diagnostic accuracy of loopamp Trypanosoma brucei detection kit for diagnosis of human African trypanosomiasis in clinical samples. (24147176)
2013
2
Structure-activity relationships of synthetic cordycepin analogues as experimental therapeutics for african trypanosomiasis. (24283924)
2013
3
Human African trypanosomiasis. (23829907)
2013
4
False positivity of non-targeted infections in malaria rapid diagnostic tests: the case of human african trypanosomiasis. (23638201)
2013
5
Patrick Manson (1844-1922) FRS: Filaria (Mansonella) perstans and sleeping sickness (African trypanosomiasis). (22791871)
2012
6
Chagas disease (American trypanosomiasis) a89 fact sheet (revised in August 2012). (23311009)
2012
7
Human African trypanosomiasis in the Democratic Republic of the Congo: a looming emergency? (23272260)
2012
8
Human African trypanosomiasis in a traveler: diagnostic pitfalls. (22855756)
2012
9
The use of Loop-mediated Isothermal Amplification (LAMP) to detect the re-emerging Human African Trypanosomiasis (HAT) in the Luangwa and Zambezi valleys. (23211002)
2012
10
Disappearance of some human African trypanosomiasis transmission foci in Zambia in the absence of a tsetse fly and trypanosomiasis control program over a period of forty years. (21276598)
2011
11
Benzoxaboroles: a new class of potential drugs for human African trypanosomiasis. (21859301)
2011
12
Melarsoprol cyclodextrin inclusion complexes as promising oral candidates for the treatment of human African trypanosomiasis. (21909447)
2011
13
Improving the cost-effectiveness of visual devices for the control of riverine tsetse flies, the major vectors of human African trypanosomiasis. (21829743)
2011
14
Abnormal biochemical and haematological indices in trypanosomiasis as a threat to herd production. (21382664)
2011
15
The central role of macrophages in trypanosomiasis-associated anemia: rationale for therapeutical approaches. (20158497)
2010
16
Diamidines for human African trypanosomiasis. (20721830)
2010
17
Trypanosomiasis, cardiomyopathy and the risk of ischemic stroke. (20450304)
2010
18
Chemotherapy against human African trypanosomiasis: is there a road to success? (20961469)
2010
19
Increased CXCL-13 levels in human African trypanosomiasis meningo-encephalitis. (19298637)
2009
20
Imported human African trypanosomiasis in Europe, 2005-2009. (19758542)
2009
21
Identification of a parasitic immunomodulatory protein triggering the development of suppressive M1 macrophages during African trypanosomiasis. (19911988)
2009
22
Comment on: Diagnosing central nervous system trypanosomiasis: two stage or not to stage. (18692858)
2009
23
The reception by French physicians of Chagas' discovery of Trypanosoma cruzi and American trypanosomiasis (1909-1925). (20027917)
2009
24
Canine Chagas' disease (American trypanosomiasis) in North America. (19932362)
2009
25
East African trypanosomiasis in a pregnant traveler. (19891893)
2009
26
Regulatory T cells prevent control of experimental African trypanosomiasis. (18250461)
2008
27
Eliminating human African trypanosomiasis: where do we stand and what comes next? (18303943)
2008
28
Correlation of the serum concentrations of tumour necrosis factor and nitric oxide with disease severity in chronic Chagas disease (American trypanosomiasis). (17316498)
2007
29
Combination chemotherapy with a substance P receptor antagonist (aprepitant) and melarsoprol in a mouse model of human African trypanosomiasis. (17643344)
2007
30
Human African trypanosomiasis in a rural community, Democratic Republic of Congo. (17479887)
2007
31
Immunology and immunopathology of African trypanosomiasis. (17143404)
2006
32
Human African trypanosomiasis-neurological aspects. (16541214)
2006
33
Toxic side effects of drugs used to treat Chagas' disease (American trypanosomiasis). (16937919)
2006
34
Treatment outcomes and risk factors for relapse in patients with early-stage human African trypanosomiasis (HAT) in the Republic of the Congo. (17128357)
2006
35
Trypanosomiasis in Venezuelan water buffaloes: association of packed-cell volumes with seroprevalence and current trypanosome infection. (16762110)
2006
36
A new initiative for the development of new diagnostic tests for human African trypanosomiasis. (16638141)
2006
37
A rare case of human trypanosomiasis caused by Trypanosoma evansi. (16505565)
2006
38
Tropical Diseases Lacking Adequate Control Measures: Dengue, Leishmaniasis, and African Trypanosomiasis (21250331)
2006
39
Human trypanosomiasis caused by Trypanosoma evansi in India: the first case report. (16172469)
2005
40
Disruptions of ultradian and circadian organization of core temperature in a rat model of African trypanosomiasis using periodogram techniques on detrended data. (16021841)
2005
41
Meningoencephalitic African trypanosomiasis: Brain IL-10 and IL-6 are associated with protection from neuro-inflammatory pathology. (16054238)
2005
42
Trypanocidal activity of N-isopropyl oxamate on cultured epimastigotes and murine trypanosomiasis using different Trypanosoma cruzi strains. (15968824)
2005
43
Effective measures for controlling trypanosomiasis. (16316303)
2005
44
African trypanosomiasis gambiense, Italy. (16318728)
2005
45
Suppression of growth and metastasizing of T-cell lymphoma in mice infected with american trypanosomiasis at different stages of experimental infection. (15455122)
2004
46
Megazol combined with suramin improves a new diagnosis index of the early meningo-encephalitic phase of experimental African trypanosomiasis. (14728611)
2004
47
Trypanosoma evansi sialidase: surface localization, properties and hydrolysis of ghost red blood cells and brain cells-implications in trypanosomiasis. (12939050)
2003
48
Arsenicals (melarsoprol), pentamidine and suramin in the treatment of human African trypanosomiasis. (12743807)
2003
49
Identification of mechanisms of natural resistance to African trypanosomiasis in cattle. (12072233)
2002
50
Veterinary link to drug resistance in human African trypanosomiasis? (11530144)
2001

Genetic Variations for Trypanosomiasis

About this section

Expression for genes affiliated with Trypanosomiasis

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Trypanosomiasis

Search GEO for disease gene expression data for Trypanosomiasis.

Pathways for genes affiliated with Trypanosomiasis

About this section
Sources:
29KEGG, 51QIAGEN, 37NCBI BioSystems Database, 12EMD Millipore, 53Reactome, 49PharmGKB
See all sources

Compounds for genes affiliated with Trypanosomiasis

About this section
Sources:
44Novoseek, 24HMDB, 11DrugBank, 28IUPHAR, 49PharmGKB
See all sources

Compounds related to Trypanosomiasis according to GeneCards/GeneDecks:

(show top 50)    (show all 72)
idCompoundScoreTop Affiliating Genes
1aspartate4411.2ODC1, TXN, APOA1, GAPDH, TF, PGD
2ascorbic acid44 2412.2ODC1, TXN, APOA1, GAPDH, TF, PGD
3alanine4411.1TXN, APOA1, GAPDH, TF, PREP, HPR
4lactate4411.1ODC1, TXN, APOA1, GAPDH, TF, PGD
5adenylate4411.1ODC1, TXN, GAPDH, HPR, PGD, TACR1
6alpha tocopherol4411.1ODC1, TXN, APOA1, TF, GSR
7trypanothione44 1112.1GSR, SRM, TXN, ODC1
8citrate4411.1ODC1, TXN, GAPDH, TF, PGD
9dehydroascorbic acid44 1112.1GSR, PGD, TF, TXN
10glyceraldehyde 3-phosphate4411.0ODC1, GAPDH, PREP, PGD, GSR
11tocopherol4411.0TXN, APOA1, TF, GSR
12vitamin a44 11 2413.0TXN, APOA1, GAPDH, TF, GSR
13fructose-1,6-bisphosphate4411.0GSR, HPR, GAPDH, TXN
14gssg4411.0TXN, GAPDH, PGD, GSR
15gsno4411.0GSR, GAPDH, TXN, ODC1
16n acetylcysteine4411.0ODC1, TXN, GAPDH, TF, GSR
17betacarotene4411.0GSR, TF, TXN, ODC1
18glutamate4411.0APOA1, PREP, TACR1
194-hydroxynonenal44 2412.0ODC1, TXN, GAPDH, GSR
20ornithine44 2412.0ODC1, GAPDH, PREP, SRM
21gnrh4411.0GSR, THOP1, PREP
22diamide4411.0TXN, GAPDH, GSR
236-phosphogluconate4411.0GSR, PGD, GAPDH
24adriamycin4411.0GSR, TF, TXN, ODC1
25selenite4410.9GSR, TF, TXN
26tert-butylhydroperoxide4410.9TXN, GAPDH, GSR
27nadp+4410.9GAPDH, PGD, GSR
28adenine44 11 2412.9GSR, TF, GAPDH, ODC1
29h2o24410.9ODC1, GAPDH, PGD
30carbohydrates4410.9ODC1, TXN, TF, HPR
31pssg4410.9GSR, GAPDH
321-aminooxy-3-aminopropane4410.9SRM, ODC1
33thyroxine44 2411.9TXN, APOA1, TF, GSR
34gamma-glutamylcysteine44 11 2412.9ODC1, TXN, GSR
35glutamine4410.9ODC1, TXN, GAPDH, TF, TACR1
36selenocystine4410.9TXN, GSR
37rotenone4410.9GSR, TXN, ODC1
38glyoxal4410.8GSR, GAPDH
39acetaldehyde44 28 2412.8TF, GAPDH, APOA1
40methotrexate44 49 1112.8ODC1, TF, PGD, GSR
41nicotinamide44 1111.8TXN, GAPDH, GSR
42malate4410.8PGD, GAPDH, TXN
43creatinine4410.7TXN, APOA1, GAPDH, TF, GSR
44selenium44 2411.7GSR, TF, TXN
45cadaverine44 2411.7SRM, ODC1
46mechlorethamine4410.6APOA1, GAPDH
47deet4410.5ODC1, GAPDH
48fotemustine44 1111.5GSR, TXN
49guanidine hydrochloride4410.5GSR, GAPDH, APOA1
50peroxynitrite4410.3TXN, GAPDH, GSR

GO Terms for genes affiliated with Trypanosomiasis

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Trypanosomiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.7TXN, CCL3L3, APOA1, APOL1, TF, HPR
2spherical high-density lipoprotein particleGO:03436610.4HPR, APOA1
3secretory granule lumenGO:03477410.2TF, APOA1

Biological processes related to Trypanosomiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1small molecule metabolic processGO:04428110.7GSR, ODC1, TXN, APOA1, GAPDH, PGD
2nucleobase-containing small molecule interconversionGO:01594910.5GSR, TXN
3positive regulation of lymphocyte proliferationGO:05067110.4TACR1, IL12A
4polyamine metabolic processGO:00659510.2SRM, ODC1

Molecular functions related to Trypanosomiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1NADP bindingGO:05066110.6GSR, PGD, GAPDH

Products for genes affiliated with Trypanosomiasis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Trypanosomiasis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet