MCID: TRY001
MIFTS: 49

Trypanosomiasis malady

Infectious diseases category

Summaries for Trypanosomiasis

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9Disease Ontology, 66Wikipedia, 34MalaCards
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Disease Ontology:9 A parasitic protozoa infectious disease that involves infection caused by parasitic protozoan of the genus trypanosoma in animals and humans.

MalaCards: Trypanosomiasis is related to sleeping sickness and chagas disease. An important gene associated with Trypanosomiasis is APOL1 (apolipoprotein L, 1), and among its related pathways are Cholesterol and Sphingolipids transport Recycling to plasma membrane in lung normal and CF and Primary immunodeficiency. The drugs pentamidine and pentamidine isethionate and the compounds 1-aminooxy-3-aminopropane and selenocystine have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and t cells.

Wikipedia:66 Trypanosomiasis or trypanosomosis is the name of several diseases in vertebrates caused by parasitic... more...

Aliases & Classifications for Trypanosomiasis

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9Disease Ontology, 46Novoseek, 63UMLS, 59SNOMED-CT, 28ICD9CM, 36MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Aliases & Descriptions:

trypanosomiasis 9 46 63


External Ids:

Disease Ontology9 DOID:10113
ICD9CM28 086, 086.9
MeSH36 D014352

Related Diseases for Trypanosomiasis

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18GeneCards, 19GeneDecks
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Diseases related to Trypanosomiasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 52)
idRelated DiseaseScoreTop Affiliating Genes
1sleeping sickness31.2ODC1, APOL1, SRM, HPR
2chagas disease31.2ODC1, SRM, GSR
3leishmaniasis31.0PGD, SRM
4malaria30.8GSR, HPR, SRM, ODC1
5amebiasis10.2
6cerebritis10.2
7encephalitis10.2
8trypanosomiasis, human east-african10.2
9babesiosis10.1
10trichinosis10.1
11louping ill10.1
12schistosomiasis10.1
13toxoplasmosis10.1
14trypanosomiasis, human west-african10.1
15glucosephosphate dehydrogenase deficiency10.1GSR, HPR
16gastric ulcer10.1GSR, ODC1
17beta thalassemia10.1GSR, TF
18primary hyperoxaluria10.1HPR, APOL1, APOA1
19hepatitis10.0TF, TXN, GSR
20adult respiratory distress syndrome10.0TXN, TF
21fatty liver disease10.0TF, TXN, APOA1
22hepatitis c10.0GSR, TXN, TF
23congenital heart disease10.0TXN, APOA1, GSR
24acute myocardial infarction10.0GSR, APOA1, TXN
25b-cell lymphomas10.0TNFRSF13C, TXN, SRM
26schizophrenia10.0ODC1, APOL1, PREP, GSR
27hepatitis b10.0GSR, APOA1, TXN
28vascular disease10.0GSR, HPR, TXN, TF
29deficiency anemia10.0TF, TXN, PGD, HPR, GSR
30chronic kidney failure10.0GSR, APOA1, TF
31diabetes mellitus10.0GSR, HPR, APOA1, TXN, TF
32c1q deficiency10.0C1QA, C1QC, C1QB
33malignant glioma10.0ODC1, PREP, CCL3L1, GSR
34trichomoniasis9.9
35orchitis9.9
36endomyocardial fibrosis9.9
37eastern equine encephalitis9.9
38onchocerciasis9.9
39pseudobulbar palsy9.9
40loiasis9.9
41cutaneous leishmaniasis9.9
42lymphocytic choriomeningitis9.9
43filariasis9.9
44microsporidiosis9.9
45myocarditis9.9
46relapsing fever9.9
47tuberculosis9.9
48yaws9.9
49helminthiasis9.9
50hiv-19.9

Graphical network of the top 20 diseases related to Trypanosomiasis:



Diseases related to trypanosomiasis

Symptoms for Trypanosomiasis

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Drugs & Therapeutics for Trypanosomiasis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Trypanosomiasis

Drug clinical trials:

Search ClinicalTrials for Trypanosomiasis

Search NIH Clinical Center for Trypanosomiasis

Search CenterWatch for Trypanosomiasis

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Trypanosomiasis

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Anatomical Context for Trypanosomiasis

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34MalaCards
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MalaCards organs/tissues related to Trypanosomiasis:

34
Testes, Brain, T cells, Heart, Skin, Myeloid, B cells, Endothelial

Animal Models for Trypanosomiasis or affiliated genes

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Publications for Trypanosomiasis

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Sources:
53PubMed
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Articles related to Trypanosomiasis:

(show top 50)    (show all 523)
idTitleAuthorsYear
1
Social factors affecting seasonal variation in bovine trypanosomiasis on the Jos Plateau, Nigeria. (24172046)
2013
2
HLA-G 3' UTR-2 haplotype is associated with Human African trypanosomiasis susceptibility. (23541412)
2013
3
An exploratory GIS-based method to identify and characterise landscapes with an elevated epidemiological risk of Rhodesian human African trypanosomiasis. (23171150)
2012
4
Modeling the control of trypanosomiasis using trypanocides or insecticide-treated livestock. (22616017)
2012
5
Human African trypanosomiasis in South Sudan: how can we prevent a new epidemic? (22666506)
2012
6
Trypanosomiasis in an infant from India. (21715739)
2011
7
Transmission of human African trypanosomiasis in the Komo-Mondah focus, Gabon. (22121444)
2011
8
Dental management of the tropical disease human African trypanosomiasis: an unusual case of pseudobulbar palsy. (21217721)
2011
9
Disappearance of some human African trypanosomiasis transmission foci in Zambia in the absence of a tsetse fly and trypanosomiasis control program over a period of forty years. (21276598)
2011
10
African trypanosomiasis. (21609334)
2011
11
Potential new drugs for human African trypanosomiasis: some progress at last. (20844428)
2010
12
Identification of Selective Inhibitors of Phosphofructokinase as Lead Compounds Against Trypanosomiasis (24027803)
2010
13
Identification of stage biomarkers for human African trypanosomiasis. (20519589)
2010
14
Novel biomarkers for late-stage human African trypanosomiasis--the search goes on. (20519588)
2010
15
Increased CXCL-13 levels in human African trypanosomiasis meningo-encephalitis. (19298637)
2009
16
Atypical human trypanosomiasis: a neglected disease or just an unlucky accident? (19162551)
2009
17
Justice where justice is due: A posthumous Nobel Prize to Carlos Chagas (1879-1934), the discoverer of American Trypanosomiasis (Chagas' disease). (19185367)
2009
18
Discovery of new S-adenosylmethionine decarboxylase inhibitors for the treatment of Human African Trypanosomiasis (HAT). (19419862)
2009
19
Chemical validation of trypanothione synthetase: a potential drug target for human trypanosomiasis. (19828449)
2009
20
Regulatory T cells prevent control of experimental African trypanosomiasis. (18250461)
2008
21
Contributions of experimental mouse models to the understanding of African trypanosomiasis. (18684669)
2008
22
American trypanosomiasis in dogs from an urban and rural area of Yucatan, Mexico. (18597661)
2008
23
Novel markers for treatment outcome in late-stage Trypanosoma brucei gambiense trypanosomiasis. (18494605)
2008
24
Sleeping glands? - The role of endocrine disorders in sleeping sickness (T.b. gambiense Human African Trypanosomiasis). (17767911)
2007
25
Trypanosomiasis by Trypanosoma vivax in cattle in the Brazilian semiarid: Description of an outbreak and lesions in the nervous system. (16965857)
2007
26
Correlation of the serum concentrations of tumour necrosis factor and nitric oxide with disease severity in chronic Chagas disease (American trypanosomiasis). (17316498)
2007
27
Drugs and drug resistance in African trypanosomiasis. (17409013)
2007
28
Development and evaluation of new diagnostic tests for human African trypanosomiasis. (16671230)
2006
29
Experimental therapy of African trypanosomiasis with a nanobody-conjugated human trypanolytic factor. (16604085)
2006
30
Transfusion-associated Chagas disease (American trypanosomiasis) in Mexico: implications for transfusion medicine in the United States. (16441610)
2006
31
Eflornithine is safer than melarsoprol for the treatment of second-stage Trypanosoma brucei gambiense human African trypanosomiasis. (16080099)
2005
32
Human trypanosomiasis caused by Trypanosoma evansi in India: the first case report. (16172469)
2005
33
Experimental trypanosomiasis in Yankasa ewes: the body weight response. (15977439)
2004
34
Congenital trypanosomiasis. (15537729)
2004
35
American trypanosomiasis (Chagas' disease): an unrecognised cause of stroke. (12640079)
2003
36
Trypanosoma evansi sialidase: surface localization, properties and hydrolysis of ghost red blood cells and brain cells-implications in trypanosomiasis. (12939050)
2003
37
Recent advances in research and control of malaria, leishmaniasis, trypanosomiasis and schistosomiasis. (15748049)
2003
38
Experimental African trypanosomiasis: IFN-gamma mediates early mortality. (12594839)
2003
39
A bloodstream Trypanosoma congolense sialidase could be involved in anemia during experimental trypanosomiasis. (12869528)
2003
40
African trypanosomiasis acquired in an urban area. (14769501)
2003
41
Types of arrhythmia among cases of American trypanosomiasis, compared with those in other cardiology patients. (12803869)
2003
42
American trypanosomiasis (Chagas' disease) and the role of molecular epidemiology in guiding control strategies. (12829559)
2003
43
African trypanosomiasis research: 100 years of progress, but questions and problems still remain. (11334927)
2001
44
Trypanosomiasis control. (11334951)
2001
45
Modeling household transmission of American trypanosomiasis. (11474111)
2001
46
An evaluation of the reactivity of the card agglutination test for trypanosomiasis (CATT) reagent in the Fontem sleeping sickness focus, Cameroon. (7839945)
1994
47
Human African trypanosomiasis (T.b. gambiense): a study of 16 fatal cases of sleeping sickness with some observations on acute reactive arsenical encephalopathy. (3703156)
1986
48
Field evaluation of Cellognost indirect haemagglutination test in the diagnosis of human trypanosomiasis (sleeping sickness) in Kura local government area of Kano State, Nigeria. (2862781)
1985
49
The experimental use of 'sentinel' goats to monitor trypanosomiasis in a Zambian sleeping sickness focus. Part I. The isolation of Trypanosoma brucei rhodesiense-like organisms from a 'sentinel' domestic goat. (6476933)
1984
50
Immunosuppression in experimental trypanosomiasis: effects of Trypanosoma brucei on immunization against louping-ill virus and lymphocytic choriomeningitis virus. (232108)
1979

Variations for Trypanosomiasis

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Expression for genes affiliated with Trypanosomiasis

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Trypanosomiasis

Search GEO for disease gene expression data for Trypanosomiasis.

Pathways for genes affiliated with Trypanosomiasis

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Sources:
51PathCards, 61Thomson Reuters, 31KEGG, 56Reactome, 52PharmGKB, 55R&D Systems, 39NCBI BioSystems Database, 54QIAGEN, 58SinoBiological
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Pathways related to Trypanosomiasis according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0APOA1, APOL1
29.8CD3D, TNFRSF13C
3
Show member pathways
9.7TXN, GSR
4
Show member pathways
9.6IL12A, CD3D
5
Show member pathways
thioredoxin pathway39
9.5GSR, APOA1, TXN
6
Show member pathways
Complement Activation, Classical Pathway39
Complement and Coagulation Cascades39
9.4C1QB, C1QC, C1QA
7
Show member pathways
Immune response Alternative complement pathway61
Immune response Lectin Induced complement pathway61
Immune response Classic complement pathway61
9.4C1QB, C1QC, C1QA
8
Show member pathways
9.4C1QA, C1QC, C1QB
99.4C1QA, C1QC, C1QB
109.4C1QA, C1QC, C1QB
11
Show member pathways
9.4HPR, APOL1, APOA1
12
Show member pathways
9.3TNFRSF13C, IL12A, CD3D
13
Show member pathways
glutathione-mediated detoxification I39
glutathione redox reactions I39
glutathione redox reactions II39
4-hydroxy-2-nonenal detoxification39
Glutathione metabolism61
Glutathione metabolism39
9.3GSR, SRM, PGD, ODC1
14
Show member pathways
9.2APOA1, C1QA, C1QC, C1QB
15
Show member pathways
9.0CD3D, IL12A, CCL3L1, TNFRSF13C
169.0C1QB, C1QC, C1QA, IL12A
178.9APOA1, APOL1, IL12A, HPR
18
Show member pathways
8.5GSR, SRM, PGD, APOA1, TXN, ODC1
19
Show member pathways
Toll-like receptor signaling pathway39
Regulation of toll-like receptor signaling pathway39
8.3CD3D, IL12A, CCL3L1, C1QA, C1QC, C1QB

Compounds for genes affiliated with Trypanosomiasis

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Sources:
46Novoseek, 52PharmGKB, 12DrugBank, 25HMDB
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Compounds related to Trypanosomiasis according to GeneCards/GeneDecks:

(show top 50)    (show all 84)
idCompoundScoreTop Affiliating Genes
11-aminooxy-3-aminopropane4610.1ODC1, SRM
2selenocystine4610.0TXN, GSR
3tositumomab52 1210.9C1QA, C1QC, C1QB
4ibritumomab52 1210.9C1QA, C1QC, C1QB
5alefacept46 1210.9C1QA, C1QC, C1QB
6bevacizumab52 1210.9C1QB, C1QC, C1QA
7gssg469.9GSR, PGD, TXN
8efalizumab46 1210.9C1QA, C1QC, C1QB
9daclizumab46 1210.9C1QB, C1QC, C1QA
10basiliximab46 1210.8C1QA, C1QC, C1QB
11natalizumab46 1210.8C1QB, C1QC, C1QA
12alemtuzumab46 1210.8C1QB, C1QC, C1QA
13gemtuzumab ozogamicin52 46 1211.8C1QA, C1QC, C1QB
14adalimumab46 52 1211.8C1QB, C1QC, C1QA
15selenite469.8TF, TXN, GSR
16gamma-glutamylcysteine46 25 1211.8ODC1, TXN, GSR
17abciximab46 1210.8C1QA, C1QC, C1QB
18gsno469.8GSR, TXN, ODC1
19cetuximab46 52 1211.8C1QB, C1QC, C1QA
20rotenone469.8ODC1, TXN, GSR
21etanercept46 52 1211.7C1QA, C1QC, C1QB
22methotrexate52 46 1211.7TF, ODC1, PGD, GSR
23dehydroascorbic acid46 1210.7TF, TXN, PGD, GSR
24betacarotene469.6TF, ODC1, TXN, GSR
25tocopherol469.6TF, TXN, APOA1, GSR
26cadaverine46 2510.6ODC1, SRM
27selenium46 2510.6TF, TXN, GSR
28citrate469.6TF, ODC1, TXN, PGD
29adriamycin469.6GSR, TXN, ODC1, TF
30trastuzumab46 52 1211.6C1QB, C1QC, C1QA
31thyroxine46 2510.5GSR, APOA1, TXN, TF
32fructose-1,6-bisphosphate469.5TXN, HPR, GSR
334-hydroxynonenal46 2510.5GSR, TXN, ODC1
34vitamin a46 25 1211.5GSR, APOA1, TXN, TF
35rituximab46 52 1211.4C1QA, C1QC, C1QB
36trypanothione46 1210.4GSR, SRM, TXN, ODC1
37alpha tocopherol469.4TF, ODC1, TXN, APOA1, GSR
38n acetylcysteine469.3TF, ODC1, TXN, GSR
39glyceraldehyde 3-phosphate469.3ODC1, PGD, PREP, GSR
40carbohydrates469.2TF, ODC1, TXN, HPR
41ascorbic acid46 2510.2TF, ODC1, TXN, APOA1, PGD, GSR
42lactate469.2TF, ODC1, TXN, APOA1, PGD, GSR
43aspartate469.2TF, ODC1, TXN, APOA1, PGD, GSR
44pge1469.2TXN, ODC1, TF
45h2o2469.1ODC1, TXN, APOA1, PGD, GSR
46gnrh468.9GSR, PREP, TXN, ODC1
47adenylate468.8ODC1, TXN, PGD, HPR, GSR
48estrogen468.6TF, ODC1, TXN, APOA1, HPR, GSR
49glutamate468.4TF, ODC1, TXN, APOA1, PGD, PREP
50alanine468.1TF, TXN, APOA1, PREP, HPR, GSR

GO Terms for genes affiliated with Trypanosomiasis

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Sources:
17Gene Ontology
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Cellular components related to Trypanosomiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1complement component C1 complexGO:00560210.0C1QA, C1QB
2secretory granule lumenGO:03477410.0APOA1, TF
3very-low-density lipoprotein particleGO:0343619.9APOL1, APOA1
4high-density lipoprotein particleGO:0343649.7APOA1, APOL1
5spherical high-density lipoprotein particleGO:0343669.7HPR, APOA1
6collagenGO:0055819.5C1QB, C1QC, C1QA
7extracellular spaceGO:0056158.9IL12A, APOL1, APOA1, C1QC, TF
8blood microparticleGO:0725628.6HPR, TF, C1QB, C1QC, APOA1, APOL1
9extracellular regionGO:0055768.2TF, C1QB, C1QC, C1QA, APOA1, APOL1

Biological processes related to Trypanosomiasis according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1lipoprotein metabolic processGO:04215710.0APOL1, APOA1
2polyamine metabolic processGO:0065959.6SRM, ODC1
3complement activationGO:0069569.6C1QA, C1QC, C1QB
4complement activation, classical pathwayGO:0069589.5C1QA, C1QC, C1QB
5nucleobase-containing small molecule interconversionGO:0159499.4GSR, TXN
6innate immune responseGO:0450878.8C1QB, C1QC, C1QA, TXN, APOL1
7small molecule metabolic processGO:0442818.5ODC1, TXN, APOA1, PGD, SRM, GSR

Molecular functions related to Trypanosomiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1NADP bindingGO:05066110.0GSR, PGD

Products for genes affiliated with Trypanosomiasis

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  • Antibodies
  • Proteins
  • Lysates
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Sources for Trypanosomiasis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet