MCID: TRY001
MIFTS: 48

Trypanosomiasis malady

Summaries for Trypanosomiasis

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Disease Ontology:8 A parasitic protozoa infectious disease that involves infection caused by parasitic protozoan of the genus trypanosoma in animals and humans.

MalaCards: Trypanosomiasis is related to chagas disease and sleeping sickness. An important gene associated with Trypanosomiasis is APOL1 (apolipoprotein L, 1), and among its related pathways are African trypanosomiasis and PEDF Induced Signaling. The drugs pentamidine and pentamidine isethionate and the compounds aspartate and ascorbic acid have been mentioned in the context of this disorder. Affiliated tissues include skin, brain and heart.

Wikipedia:64 Trypanosomiasis or trypanosomosis is the name of several diseases in vertebrates caused by parasitic... more...

Aliases & Classifications for Trypanosomiasis

Sources:
8Disease Ontology, 45Novoseek, 61UMLS, 27ICD9CM, 57SNOMED-CT, 35MeSH
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Aliases & Descriptions:

trypanosomiasis 8 45 61


External Ids:

Disease Ontology8 DOID:10113
ICD9CM27 086, 086.9
MeSH35 D014352

Related Diseases for Trypanosomiasis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Trypanosomiasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 72)
idRelated DiseaseScoreTop Affiliating Genes
1chagas disease31.1SRM, GSR, GAPDH, ODC1
2sleeping sickness31.0HPR, ODC1, APOL1, SRM
3tuberculosis29.9HPR, GSR, GAPDH
4trypanosomiasis, human west-african10.3
5trypanosomiasis, human east-african10.3
6amebiasis10.2
7babesiosis10.1
8trichinosis10.1
9toxoplasmosis10.1
10deficiency anemia10.0TXN, GAPDH, TF, HPR, PGD, GSR
11schizophrenia10.0GSR, PREP, GAPDH, APOL1, TACR1, ODC1
12malaria10.0SRM, GSR, ODC1, HPR, GAPDH
13diabetes mellitus10.0APOA1, GAPDH, TF, GSR, TXN, HPR
14alzheimer's disease10.0TACR1, PREP, GAPDH, TXN, GSR
15vascular disease10.0HPR, GSR, TF, GAPDH, TXN
16rheumatoid arthritis10.0TXN, TNFRSF13C, APOA1, TACR1
17arthritis10.0TACR1, TXN, HPR
18hepatitis b10.0GSR, APOA1, TXN
19asthma10.0GAPDH, TACR1, GSR
20leishmaniasis10.0SRM, PGD
21leukemia10.0ODC1, GAPDH
22multiple sclerosis10.0GSR, APOA1, TNFRSF13C
23glucosephosphate dehydrogenase deficiency10.0HPR, GSR
24cataract10.0GSR, GAPDH, TXN
25osteoarthritis10.0TACR1, GSR
26acute myocardial infarction10.0GSR, TXN, APOA1
27hepatocellular carcinoma10.0TXN, GAPDH, TF
28sarcoma10.0GAPDH, ODC1
29pneumonia10.0TXN
30breast cancer10.0TXN, ODC1, GAPDH, HPR, GSR
31glioblastoma multiforme10.0ODC1, GAPDH, TACR1
32atherosclerosis10.0APOA1, TXN
33influenza10.0TXN
34adenocarcinoma10.0TACR1, ODC1, GAPDH
35psoriasis10.0TACR1, ODC1
36ischemia10.0GSR
37infertility10.0GAPDH
38hepatitis10.0TXN, TF, GSR
39hyperglycemia10.0TXN
40cholera10.0ODC1, TF
41pancreatitis10.0TACR1
42galactosemia10.0TF, HPR
43coronary heart disease10.0GSR, APOA1
44fatty liver disease10.0APOA1, TXN, TF
45malignant glioma10.0TACR1, GSR, PREP, ODC1, CCL3L1
46acute pancreatitis10.0TACR1
47alcohol abuse10.0TF
48gastritis10.0TXN, ODC1
49prion disease10.0TF
50sarcoidosis10.0TXN, TACR1

Graphical network of the top 20 diseases related to Trypanosomiasis:



Diseases related to trypanosomiasis

Clinical Features for Trypanosomiasis

Drugs & Therapeutics for Trypanosomiasis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Trypanosomiasis

Drug clinical trials:

Search ClinicalTrials for Trypanosomiasis

Search NIH Clinical Center for Trypanosomiasis

Search CenterWatch for Trypanosomiasis

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Trypanosomiasis

Anatomical Context for Trypanosomiasis

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Trypanosomiasis:

33
Skin, Brain, Heart, Salivary gland, Myeloid, Monocytes, T cells, B cells, Endothelial

Animal Models for Trypanosomiasis or affiliated genes

Sources:
28inGenious Targeting Laboratory
See all sources

Publications for Trypanosomiasis

Sources:
51PubMed
See all sources

Articles related to Trypanosomiasis:

(show top 50)    (show all 527)
idTitleAuthorsYear
1
Haptoglobin (HP) and Haptoglobin-related protein (HPR) copy number variation, natural selection, and trypanosomiasis. (24005574)
2014
2
Evaluating paratransgenesis as a potential control strategy for African trypanosomiasis. (23967363)
2013
3
Socio-economic and cultural determinants of human african trypanosomiasis at the Kenya - Uganda transboundary. (23638206)
2013
4
Proteomics: a new way to improve human African trypanosomiasis diagnosis? (23777218)
2013
5
Genetically distinct Glossina fuscipes fuscipes populations in the Lake Kyoga region of Uganda and its relevance for human African trypanosomiasis. (24199195)
2013
6
Trypanosoma cruzi trans-sialidase as a drug target against Chagas disease (American trypanosomiasis). (24144418)
2013
7
Hemoculture and Polymerase Chain Reaction Using Primers TCZ1/TCZ2 for the Diagnosis of Canine and Feline Trypanosomiasis. (23738124)
2012
8
Human african trypanosomiasis diagnosis in first-line health services of endemic countries, a systematic review. (23209860)
2012
9
Prevalence of human African trypanosomiasis in the Democratic Republic of the Congo. (21829736)
2011
10
1-Aryl-4-nitro-1H-imidazoles, a new promising series for the treatment of human African trypanosomiasis. (21353728)
2011
11
Magnetic resonance imaging to assess blood-brain barrier damage in murine trypanosomiasis. (21292912)
2011
12
Diagnostic accuracy and feasibility of serological tests on filter paper samples for outbreak detection of T.b. gambiense human African trypanosomiasis. (20682885)
2010
13
The Atlas of human African trypanosomiasis: a contribution to global mapping of neglected tropical diseases. (21040555)
2010
14
Emerging trends in the diagnosis of human African Trypanosomiasis. (20380768)
2010
15
Tripartite interactions between tsetse flies, Sodalis glossinidius and trypanosomes--an epidemiological approach in two historical human African trypanosomiasis foci in Cameroon. (19879380)
2010
16
Atypical human trypanosomiasis: a neglected disease or just an unlucky accident? (19162551)
2009
17
Prospects for developing odour baits to control Glossina fuscipes spp., the major vector of human African trypanosomiasis. (19434232)
2009
18
Comparison of operational criteria for treatment outcome in gambiense human African trypanosomiasis. (19228348)
2009
19
Cytokines in central nervous system trypanosomiasis: cause, effect or both? (18814893)
2009
20
Contributions of experimental mouse models to the understanding of African trypanosomiasis. (18684669)
2008
21
American trypanosomiasis in dogs from an urban and rural area of Yucatan, Mexico. (18597661)
2008
22
Hypocretin and human African trypanosomiasis. (18363311)
2008
23
Polymorphic microsatellite markers for the tsetse fly Glossina fuscipes fuscipes (Diptera: Glossinidae), a vector of human African trypanosomiasis. (21586090)
2008
24
Efficacy of the diamidine DB75 and its prodrug DB289, against murine models of human African trypanosomiasis. (18722336)
2008
25
Human African trypanosomiasis: pharmacological re-engagement with a neglected disease. (17618313)
2007
26
The PCR-based detection of Trypanosoma cruzi in the faeces of Triatoma infestans fed on patients with chronic American trypanosomiasis gives higher sensitivity and a quicker result than routine xenodiagnosis. (18028728)
2007
27
Natural products to anti-trypanosomal drugs: an overview of new drug prototypes for American Trypanosomiasis. (17630949)
2007
28
Natural products from plants as drug candidates and lead compounds against leishmaniasis and trypanosomiasis. (17017912)
2006
29
Experimental African trypanosomiasis: lack of effective CD1d-restricted antigen presentation. (17096643)
2006
30
Experimental African trypanosomiasis: a subset of pathogenic, IFN-gamma-producing, MHC class II-restricted CD4+ T cells mediates early mortality in highly susceptible mice. (16424202)
2006
31
Clinical aspects of 2541 patients with second stage human African trypanosomiasis. (16157286)
2006
32
An update on Chagas disease (human American trypanosomiasis). (17227647)
2006
33
Comparison of the transmissibility of Trypanosoma congolense strains, isolated in a trypanosomiasis endemic area of eastern Zambia, by Glossina morsitans morsitans. (16719960)
2006
34
Eflornithine is safer than melarsoprol for the treatment of second-stage Trypanosoma brucei gambiense human African trypanosomiasis. (16080099)
2005
35
Protein farnesyl transferase inhibitors for the treatment of malaria and African trypanosomiasis. (16121685)
2005
36
Review Article: cerebrospinal fluid in human African trypanosomiasis: a key to diagnosis, therapeutic decision and post-treatment follow-up. (15860085)
2005
37
Current status and future prospects for a vaccine against American trypanosomiasis. (16372882)
2005
38
Bovine trypanosomiasis in south-western Uganda: packed-cell volumes and prevalences of infection in the cattle. (15000727)
2004
39
Human African trypanosomiasis amongst urban residents in Kinshasa: a case-control study. (15303991)
2004
40
American trypanosomiasis and electrocardiographic alterations among industrial workers in SALo Paulo, Brazil. (15654473)
2004
41
Novel azasterols as potential agents for treatment of leishmaniasis and trypanosomiasis. (15273104)
2004
42
American trypanosomiasis (Chagas' disease): an unrecognised cause of stroke. (12640079)
2003
43
Cattle owners' perceptions of African bovine trypanosomiasis and its control in Busia and Kwale Districts of Kenya. (12711100)
2003
44
Evaluation of a polymerase chain reaction assay for the diagnosis of bovine trypanosomiasis and epidemiological surveillance in Bolivia. (14613492)
2003
45
Eflornithine for the treatment of human African trypanosomiasis. (12811548)
2003
46
Interactions between tsetse and trypanosomes with implications for the control of trypanosomiasis. (14587696)
2003
47
Cerebral trypanosomiasis and AIDS. (12364939)
2002
48
Trypanosomiasis control. (11334951)
2001
49
Availability and affordability of treatment for Human African Trypanosomiasis. (11703853)
2001
50
Haematological studies on domestic animals in Nigeria. IV. Clinico-haematological features of bovine trypanosomiasis, theileriosis, anaplasmosis, eperythrozoonosis and helminthiasis. (7223184)
1980

Genetic Variations for Trypanosomiasis

Expression for genes affiliated with Trypanosomiasis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Trypanosomiasis

Search GEO for disease gene expression data for Trypanosomiasis.

Pathways for genes affiliated with Trypanosomiasis

Sources:
30KEGG, 52QIAGEN, 38NCBI BioSystems Database, 12EMD Millipore, 54Reactome, 50PharmGKB
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Compounds for genes affiliated with Trypanosomiasis

Sources:
45Novoseek, 24HMDB, 11DrugBank, 29IUPHAR, 50PharmGKB
See all sources

Compounds related to Trypanosomiasis according to GeneCards/GeneDecks:

(show top 50)    (show all 72)
idCompoundScoreTop Affiliating Genes
1aspartate4511.2TXN, GSR, TACR1, PGD, TF, GAPDH
2ascorbic acid45 2412.2TF, PGD, APOA1, GSR, ODC1, TXN
3alanine4511.1GSR, TXN, TACR1, HPR, PREP, TF
4lactate4511.1TXN, APOA1, GAPDH, GSR, TF, PGD
5adenylate4511.1HPR, GAPDH, GSR, TACR1, PGD, TXN
6alpha tocopherol4511.1TXN, APOA1, TF, GSR, ODC1
7trypanothione45 1112.1SRM, TXN, GSR, ODC1
8citrate4511.1TXN, PGD, TF, GAPDH, ODC1
9dehydroascorbic acid45 1112.1TF, TXN, PGD, GSR
10glyceraldehyde 3-phosphate4511.0GAPDH, PGD, GSR, PREP, ODC1
11tocopherol4511.0TF, TXN, APOA1, GSR
12vitamin a45 11 2413.0GSR, TXN, APOA1, GAPDH, TF
13fructose-1,6-bisphosphate4511.0GSR, HPR, TXN, GAPDH
14gssg4511.0PGD, GAPDH, TXN, GSR
15gsno4511.0TXN, ODC1, GAPDH, GSR
16n acetylcysteine4511.0ODC1, GSR, TF, GAPDH, TXN
17betacarotene4511.0TXN, TF, GSR, ODC1
18glutamate4511.0PREP, TACR1, APOA1
194-hydroxynonenal45 2412.0GSR, GAPDH, TXN, ODC1
20ornithine45 2412.0SRM, GAPDH, ODC1, PREP
21gnrh4511.0GSR, THOP1, PREP
22diamide4511.0GSR, TXN, GAPDH
236-phosphogluconate4511.0PGD, GSR, GAPDH
24adriamycin4511.0TF, GSR, ODC1, TXN
25selenite4510.9TF, GSR, TXN
26tert-butylhydroperoxide4510.9GAPDH, GSR, TXN
27nadp+4510.9PGD, GAPDH, GSR
28adenine45 11 2412.9ODC1, GAPDH, TF, GSR
29h2o24510.9PGD, ODC1, GAPDH
30carbohydrates4510.9HPR, TF, ODC1, TXN
31pssg4510.9GSR, GAPDH
321-aminooxy-3-aminopropane4510.9SRM, ODC1
33thyroxine45 2411.9TXN, APOA1, TF, GSR
34gamma-glutamylcysteine45 11 2412.9ODC1, TXN, GSR
35glutamine4510.9ODC1, TF, TXN, TACR1, GAPDH
36selenocystine4510.9GSR, TXN
37rotenone4510.9ODC1, TXN, GSR
38glyoxal4510.8GSR, GAPDH
39acetaldehyde45 29 2412.8GAPDH, TF, APOA1
40methotrexate45 50 1112.8GSR, ODC1, TF, PGD
41nicotinamide45 1111.8TXN, GAPDH, GSR
42malate4510.8GAPDH, PGD, TXN
43creatinine4510.7GAPDH, APOA1, TXN, GSR, TF
44selenium45 2411.7TXN, TF, GSR
45cadaverine45 2411.7ODC1, SRM
46deet4510.6GAPDH, ODC1
47mechlorethamine4510.5GAPDH, APOA1
48fotemustine45 1111.5GSR, TXN
49guanidine hydrochloride4510.5APOA1, GAPDH, GSR
50peroxynitrite4510.3GAPDH, GSR, TXN

GO Terms for genes affiliated with Trypanosomiasis

Sources:
16Gene Ontology
See all sources

Cellular components related to Trypanosomiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.7C1QC, TXN, CCL3L3, APOA1, APOL1, TF
2spherical high-density lipoprotein particleGO:03436610.4APOA1, HPR
3secretory granule lumenGO:03477410.2APOA1, TF

Biological processes related to Trypanosomiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1small molecule metabolic processGO:04428110.7PGD, ODC1, TXN, GSR, SRM, PLCB2
2nucleobase-containing small molecule interconversionGO:01594910.5TXN, GSR
3positive regulation of lymphocyte proliferationGO:05067110.4TACR1, IL12A
4polyamine metabolic processGO:00659510.2ODC1, SRM

Molecular functions related to Trypanosomiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1NADP bindingGO:05066110.6GSR, PGD, GAPDH

Products for genes affiliated with Trypanosomiasis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Trypanosomiasis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet