MCID: TRY001
MIFTS: 50

Trypanosomiasis malady

Infectious diseases category
Download this MalaCard

Summaries for Trypanosomiasis

About this section


Fully expand this MalaCard
Disease Ontology:8 A parasitic protozoa infectious disease that involves infection caused by parasitic protozoan of the genus trypanosoma in animals and humans.

MalaCards based summary: Trypanosomiasis is related to chagas disease and sleeping sickness. An important gene associated with Trypanosomiasis is APOL1 (apolipoprotein L, 1), and among its related pathways are Cholesterol and Sphingolipids transport Recycling to plasma membrane in lung normal and CF and Primary immunodeficiency. The drugs pentamidine and pentamidine isethionate and the compounds 1-aminooxy-3-aminopropane and selenocystine have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and t cells.

Wikipedia:65 Trypanosomiasis or trypanosomosis is the name of several diseases in vertebrates caused by parasitic... more...

Aliases & Classifications for Trypanosomiasis

About this section
Sources:
8Disease Ontology, 44Novoseek, 62UMLS, 57SNOMED-CT, 34MeSH, 27ICD9CM
See all sources

Trypanosomiasis, Aliases & Descriptions:

Name: Trypanosomiasis 8 44 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


External Ids:

Disease Ontology8 DOID:10113
MeSH34 D014352
ICD9CM27 086.9, 086

Related Diseases for Trypanosomiasis

About this section

Diseases related to Trypanosomiasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 52)
idRelated DiseaseScoreTop Affiliating Genes
1chagas disease31.6ODC1, SRM, GSR
2sleeping sickness31.5ODC1, APOL1, SRM, HPR
3leishmaniasis31.4PGD, SRM
4malaria31.0GSR, HPR, SRM, ODC1
5glucosephosphate dehydrogenase deficiency10.4GSR, HPR
6gastric ulcer10.3GSR, ODC1
7cerebritis10.3
8beta thalassemia10.3GSR, TF
9primary hyperoxaluria10.2HPR, APOL1, APOA1
10amebiasis10.2
11encephalitis10.2
12schistosomiasis10.2
13hepatitis10.2TF, TXN, GSR
14adult respiratory distress syndrome10.2TXN, TF
15fatty liver disease10.2TF, TXN, APOA1
16hepatitis c10.2GSR, TXN, TF
17congenital heart disease10.2TXN, APOA1, GSR
18acute myocardial infarction10.2GSR, APOA1, TXN
19b-cell lymphomas10.1TNFRSF13C, TXN, SRM
20babesiosis10.1
21trichinosis10.1
22louping ill10.1
23toxoplasmosis10.1
24trypanosomiasis, human east-african10.1
25trypanosomiasis, human west-african10.1
26schizophrenia10.1ODC1, APOL1, PREP, GSR
27hepatitis b10.1GSR, APOA1, TXN
28vascular disease10.1GSR, HPR, TXN, TF
29deficiency anemia10.0TF, TXN, PGD, HPR, GSR
30chronic kidney failure10.0GSR, APOA1, TF
31diabetes mellitus10.0GSR, HPR, APOA1, TXN, TF
32cutaneous leishmaniasis10.0
33hiv/aids10.0
34hiv-110.0
35orchitis10.0
36trichomoniasis10.0
37endomyocardial fibrosis10.0
38loiasis10.0
39onchocerciasis10.0
40pseudobulbar palsy10.0
41lymphocytic choriomeningitis10.0
42eastern equine encephalitis10.0
43filariasis10.0
44microsporidiosis10.0
45myocarditis10.0
46relapsing fever10.0
47tuberculosis10.0
48yaws10.0
49helminthiasis10.0
50endotheliitis10.0

Graphical network of the top 20 diseases related to Trypanosomiasis:



Diseases related to trypanosomiasis

Symptoms for Trypanosomiasis

About this section

Drugs & Therapeutics for Trypanosomiasis

About this section

Drug clinical trials:

Search ClinicalTrials for Trypanosomiasis

Search NIH Clinical Center for Trypanosomiasis

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Trypanosomiasis

About this section

Anatomical Context for Trypanosomiasis

About this section

MalaCards organs/tissues related to Trypanosomiasis:

32
Testes, Brain, T cells, Heart, Skin, Myeloid, B cells, Endothelial

Animal Models for Trypanosomiasis or affiliated genes

About this section

Publications for Trypanosomiasis

About this section

Articles related to Trypanosomiasis:

(show top 50)    (show all 541)
idTitleAuthorsYear
1
Delivery of Antihuman African Trypanosomiasis Drugs Across the Blood-Brain and Blood-CSF Barriers. (25307219)
2014
2
Oral Multicomponent DNA Vaccine Delivered by Attenuated Salmonella Elicited Immunoprotection Against American Trypanosomiasis. (25160983)
2014
3
Social factors affecting seasonal variation in bovine trypanosomiasis on the Jos Plateau, Nigeria. (24172046)
2013
4
HLA-G 3' UTR-2 haplotype is associated with Human African trypanosomiasis susceptibility. (23541412)
2013
5
An exploratory GIS-based method to identify and characterise landscapes with an elevated epidemiological risk of Rhodesian human African trypanosomiasis. (23171150)
2012
6
Modeling the control of trypanosomiasis using trypanocides or insecticide-treated livestock. (22616017)
2012
7
Trypanosomiasis in an infant from India. (21715739)
2011
8
Transmission of human African trypanosomiasis in the Komo-Mondah focus, Gabon. (22121444)
2011
9
Dental management of the tropical disease human African trypanosomiasis: an unusual case of pseudobulbar palsy. (21217721)
2011
10
Disappearance of some human African trypanosomiasis transmission foci in Zambia in the absence of a tsetse fly and trypanosomiasis control program over a period of forty years. (21276598)
2011
11
African trypanosomiasis. (21609334)
2011
12
Potential new drugs for human African trypanosomiasis: some progress at last. (20844428)
2010
13
Identification of Selective Inhibitors of Phosphofructokinase as Lead Compounds Against Trypanosomiasis (24027803)
2010
14
Identification of stage biomarkers for human African trypanosomiasis. (20519589)
2010
15
Novel biomarkers for late-stage human African trypanosomiasis--the search goes on. (20519588)
2010
16
Increased CXCL-13 levels in human African trypanosomiasis meningo-encephalitis. (19298637)
2009
17
Atypical human trypanosomiasis: a neglected disease or just an unlucky accident? (19162551)
2009
18
Justice where justice is due: A posthumous Nobel Prize to Carlos Chagas (1879-1934), the discoverer of American Trypanosomiasis (Chagas' disease). (19185367)
2009
19
Discovery of new S-adenosylmethionine decarboxylase inhibitors for the treatment of Human African Trypanosomiasis (HAT). (19419862)
2009
20
Chemical validation of trypanothione synthetase: a potential drug target for human trypanosomiasis. (19828449)
2009
21
Regulatory T cells prevent control of experimental African trypanosomiasis. (18250461)
2008
22
Contributions of experimental mouse models to the understanding of African trypanosomiasis. (18684669)
2008
23
American trypanosomiasis in dogs from an urban and rural area of Yucatan, Mexico. (18597661)
2008
24
Novel markers for treatment outcome in late-stage Trypanosoma brucei gambiense trypanosomiasis. (18494605)
2008
25
Sleeping glands? - The role of endocrine disorders in sleeping sickness (T.b. gambiense Human African Trypanosomiasis). (17767911)
2007
26
Trypanosomiasis by Trypanosoma vivax in cattle in the Brazilian semiarid: Description of an outbreak and lesions in the nervous system. (16965857)
2007
27
Correlation of the serum concentrations of tumour necrosis factor and nitric oxide with disease severity in chronic Chagas disease (American trypanosomiasis). (17316498)
2007
28
Drugs and drug resistance in African trypanosomiasis. (17409013)
2007
29
Development and evaluation of new diagnostic tests for human African trypanosomiasis. (16671230)
2006
30
Experimental therapy of African trypanosomiasis with a nanobody-conjugated human trypanolytic factor. (16604085)
2006
31
Transfusion-associated Chagas disease (American trypanosomiasis) in Mexico: implications for transfusion medicine in the United States. (16441610)
2006
32
Eflornithine is safer than melarsoprol for the treatment of second-stage Trypanosoma brucei gambiense human African trypanosomiasis. (16080099)
2005
33
Human trypanosomiasis caused by Trypanosoma evansi in India: the first case report. (16172469)
2005
34
Experimental trypanosomiasis in Yankasa ewes: the body weight response. (15977439)
2004
35
Congenital trypanosomiasis. (15537729)
2004
36
Trypanosoma evansi sialidase: surface localization, properties and hydrolysis of ghost red blood cells and brain cells-implications in trypanosomiasis. (12939050)
2003
37
Recent advances in research and control of malaria, leishmaniasis, trypanosomiasis and schistosomiasis. (15748049)
2003
38
Experimental African trypanosomiasis: IFN-gamma mediates early mortality. (12594839)
2003
39
A bloodstream Trypanosoma congolense sialidase could be involved in anemia during experimental trypanosomiasis. (12869528)
2003
40
African trypanosomiasis acquired in an urban area. (14769501)
2003
41
Types of arrhythmia among cases of American trypanosomiasis, compared with those in other cardiology patients. (12803869)
2003
42
American trypanosomiasis (Chagas' disease) and the role of molecular epidemiology in guiding control strategies. (12829559)
2003
43
African trypanosomiasis research: 100 years of progress, but questions and problems still remain. (11334927)
2001
44
Trypanosomiasis control. (11334951)
2001
45
Modeling household transmission of American trypanosomiasis. (11474111)
2001
46
An evaluation of the reactivity of the card agglutination test for trypanosomiasis (CATT) reagent in the Fontem sleeping sickness focus, Cameroon. (7839945)
1994
47
Human African trypanosomiasis (T.b. gambiense): a study of 16 fatal cases of sleeping sickness with some observations on acute reactive arsenical encephalopathy. (3703156)
1986
48
Field evaluation of Cellognost indirect haemagglutination test in the diagnosis of human trypanosomiasis (sleeping sickness) in Kura local government area of Kano State, Nigeria. (2862781)
1985
49
The experimental use of 'sentinel' goats to monitor trypanosomiasis in a Zambian sleeping sickness focus. Part I. The isolation of Trypanosoma brucei rhodesiense-like organisms from a 'sentinel' domestic goat. (6476933)
1984
50
Immunosuppression in experimental trypanosomiasis: effects of Trypanosoma brucei on immunization against louping-ill virus and lymphocytic choriomeningitis virus. (232108)
1979

Variations for Trypanosomiasis

About this section

Expression for genes affiliated with Trypanosomiasis

About this section
Expression patterns in normal tissues for genes affiliated with Trypanosomiasis

Search GEO for disease gene expression data for Trypanosomiasis.

Pathways for genes affiliated with Trypanosomiasis

About this section

Pathways related to Trypanosomiasis according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0APOA1, APOL1
29.8CD3D, TNFRSF13C
3
Show member pathways
9.7TXN, GSR
4
Show member pathways
9.6IL12A, CD3D
5
Show member pathways
thioredoxin pathway37
9.5GSR, APOA1, TXN
6
Show member pathways
Complement Activation, Classical Pathway37
Complement and Coagulation Cascades37
9.4C1QB, C1QC, C1QA
7
Show member pathways
Immune response Alternative complement pathway60
Immune response Lectin Induced complement pathway60
Immune response Classic complement pathway60
9.4C1QB, C1QC, C1QA
8
Show member pathways
9.4C1QA, C1QC, C1QB
99.4C1QA, C1QC, C1QB
109.4C1QA, C1QC, C1QB
11
Show member pathways
9.4HPR, APOL1, APOA1
12
Show member pathways
9.3TNFRSF13C, IL12A, CD3D
13
Show member pathways
glutathione-mediated detoxification I37
glutathione redox reactions I37
glutathione redox reactions II37
4-hydroxy-2-nonenal detoxification37
Glutathione metabolism60
Glutathione metabolism37
9.3GSR, SRM, PGD, ODC1
14
Show member pathways
9.2APOA1, C1QA, C1QC, C1QB
15
Show member pathways
9.0CD3D, IL12A, CCL3L1, TNFRSF13C
169.0C1QB, C1QC, C1QA, IL12A
178.9APOA1, APOL1, IL12A, HPR
18
Show member pathways
8.5GSR, SRM, PGD, APOA1, TXN, ODC1
19
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
8.3CD3D, IL12A, CCL3L1, C1QA, C1QC, C1QB

Compounds for genes affiliated with Trypanosomiasis

About this section
Sources:
44Novoseek, 50PharmGKB, 11DrugBank, 24HMDB
See all sources

Compounds related to Trypanosomiasis according to GeneCards/GeneDecks:

(show top 50)    (show all 84)
idCompoundScoreTop Affiliating Genes
11-aminooxy-3-aminopropane4410.1SRM, ODC1
2selenocystine4410.0GSR, TXN
3tositumomab50 1110.9C1QC, C1QA, C1QB
4ibritumomab50 1110.9C1QC, C1QA, C1QB
5alefacept44 1110.9C1QA, C1QC, C1QB
6bevacizumab50 1110.9C1QC, C1QB, C1QA
7gssg449.9TXN, GSR, PGD
8efalizumab44 1110.9C1QA, C1QC, C1QB
9daclizumab44 1110.9C1QB, C1QA, C1QC
10basiliximab44 1110.8C1QA, C1QC, C1QB
11alemtuzumab44 1110.8C1QB, C1QC, C1QA
12natalizumab44 1110.8C1QA, C1QC, C1QB
13gemtuzumab ozogamicin50 44 1111.8C1QA, C1QC, C1QB
14adalimumab44 50 1111.8C1QB, C1QC, C1QA
15selenite449.8TF, GSR, TXN
16gamma-glutamylcysteine44 24 1111.8ODC1, TXN, GSR
17abciximab44 1110.8C1QB, C1QA, C1QC
18gsno449.8TXN, ODC1, GSR
19cetuximab44 50 1111.8C1QC, C1QB, C1QA
20rotenone449.8ODC1, TXN, GSR
21etanercept44 50 1111.7C1QB, C1QC, C1QA
22methotrexate50 44 1111.7GSR, TF, ODC1, PGD
23dehydroascorbic acid44 1110.7GSR, TF, TXN, PGD
24betacarotene449.6GSR, TXN, ODC1, TF
25tocopherol449.6GSR, TF, APOA1, TXN
26cadaverine44 2410.6SRM, ODC1
27selenium44 2410.6GSR, TF, TXN
28citrate449.6PGD, TXN, ODC1, TF
29adriamycin449.6TF, ODC1, TXN, GSR
30trastuzumab44 50 1111.6C1QB, C1QA, C1QC
31thyroxine44 2410.5GSR, TXN, APOA1, TF
32fructose-1,6-bisphosphate449.5GSR, HPR, TXN
334-hydroxynonenal44 2410.5TXN, GSR, ODC1
34vitamin a44 24 1111.5TXN, GSR, APOA1, TF
35rituximab44 50 1111.4C1QB, C1QC, C1QA
36trypanothione44 1110.4ODC1, TXN, SRM, GSR
37alpha tocopherol449.4GSR, APOA1, TXN, ODC1, TF
38n acetylcysteine449.3ODC1, GSR, TXN, TF
39glyceraldehyde 3-phosphate449.3ODC1, PGD, PREP, GSR
40carbohydrates449.2TXN, HPR, TF, ODC1
41ascorbic acid44 2410.2ODC1, TXN, APOA1, PGD, GSR, TF
42lactate449.2ODC1, TF, TXN, APOA1, PGD, GSR
43aspartate449.2TXN, APOA1, TF, ODC1, PGD, GSR
44pge1449.2TXN, TF, ODC1
45h2o2449.1GSR, PGD, APOA1, TXN, ODC1
46gnrh448.9GSR, PREP, ODC1, TXN
47adenylate448.8PGD, TXN, ODC1, HPR, GSR
48estrogen448.6ODC1, TXN, APOA1, HPR, GSR, TF
49glutamate448.4GSR, PGD, APOA1, PREP, ODC1, TF
50alanine448.1GSR, HPR, PREP, APOA1, TXN, TF

GO Terms for genes affiliated with Trypanosomiasis

About this section

Cellular components related to Trypanosomiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1complement component C1 complexGO:00560210.0C1QA, C1QB
2secretory granule lumenGO:03477410.0APOA1, TF
3very-low-density lipoprotein particleGO:0343619.9APOL1, APOA1
4high-density lipoprotein particleGO:0343649.7APOA1, APOL1
5spherical high-density lipoprotein particleGO:0343669.7HPR, APOA1
6collagenGO:0055819.5C1QB, C1QC, C1QA
7extracellular spaceGO:0056158.9IL12A, APOL1, APOA1, C1QC, TF
8blood microparticleGO:0725628.6HPR, TF, C1QB, C1QC, APOA1, APOL1
9extracellular regionGO:0055768.2TF, C1QB, C1QC, C1QA, APOA1, APOL1

Biological processes related to Trypanosomiasis according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1lipoprotein metabolic processGO:04215710.0APOL1, APOA1
2polyamine metabolic processGO:0065959.6SRM, ODC1
3complement activationGO:0069569.6C1QA, C1QC, C1QB
4complement activation, classical pathwayGO:0069589.5C1QA, C1QC, C1QB
5nucleobase-containing small molecule interconversionGO:0159499.4GSR, TXN
6innate immune responseGO:0450878.8C1QB, C1QC, C1QA, TXN, APOL1
7small molecule metabolic processGO:0442818.5ODC1, TXN, APOA1, PGD, SRM, GSR

Molecular functions related to Trypanosomiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1NADP bindingGO:05066110.0GSR, PGD

Products for genes affiliated with Trypanosomiasis

About this section
  • Antibodies
  • Proteins
  • Lysates

Sources for Trypanosomiasis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet