MCID: TSH001
MIFTS: 37

Tsh Producing Pituitary Tumor malady

Categories: Endocrine diseases, Rare diseases, Cancer diseases

Aliases & Classifications for Tsh Producing Pituitary Tumor

Aliases & Descriptions for Tsh Producing Pituitary Tumor:

Name: Tsh Producing Pituitary Tumor 12 14
Thyrotroph Adenoma 12 56 69
Thyroid Stimulating Hormone-Secreting Pituitary Adenoma 56
Thyroid Stimulating Hormone-Producing Pituitary Tumor 69
Tsh Secreting Adenoma of the Pituitary 12
Tsh Secreting Tumor of Pituitary 12
Tsh-Secreting Pituitary Adenoma 56
Pituitary Thyrotrophic Adenoma 56
Tsh-Oma 56

Classifications:

Orphanet: 56  
Rare endocrine diseases


External Ids:

Disease Ontology 12 DOID:6275
NCIt 47 C8011
SNOMED-CT 64 254959007
Orphanet 56 ORPHA91347
UMLS via Orphanet 70 C0346303
ICD10 via Orphanet 34 D35.2
UMLS 69 C0346303

Summaries for Tsh Producing Pituitary Tumor

MalaCards based summary : Tsh Producing Pituitary Tumor, also known as thyrotroph adenoma, is related to pituitary adenoma and african histoplasmosis, and has symptoms including fatigue, headache and seizures. An important gene associated with Tsh Producing Pituitary Tumor is TSHB (Thyroid Stimulating Hormone Beta), and among its related pathways/superpathways are Peptide ligand-binding receptors and Peptide hormone metabolism. The drugs Octreotide and Gastrointestinal Agents have been mentioned in the context of this disorder. Affiliated tissues include pituitary, thyroid and testes.

Related Diseases for Tsh Producing Pituitary Tumor

Diseases related to Tsh Producing Pituitary Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 52)
id Related Disease Score Top Affiliating Genes
1 pituitary adenoma 10.6
2 african histoplasmosis 10.1 PRL SST
3 extragonadal nonseminomatous germ cell tumor 10.1 PRL SST
4 lung occult small cell carcinoma 10.0 PRL SST
5 nonparalytic poliomyelitis 10.0 PRL SST
6 pituitary adenoma, acth-secreting 10.0 PRL SST
7 merkel cell carcinoma 10.0 PRL SST
8 esophagus squamous cell papilloma 10.0 PRL SST
9 immune system organ benign neoplasm 10.0 PRL SST
10 adrenal cortical adenocarcinoma 10.0 PRL SST
11 aflatoxins-related hepatocellular carcinoma 10.0 PRL TSHB
12 pituitary tumors 10.0
13 pemphigus vegetans 10.0 GH1 SST
14 graves' disease 10.0
15 hyperthyroidism 10.0
16 endocrine organ benign neoplasm 10.0 PRL SST
17 7q11.23 duplication syndrome 10.0 GH1 PRL
18 grin2a-related speech disorders and epilepsy 10.0 GH1 PRL
19 congenital tricuspid stenosis 9.9 GH1 PRL
20 intermittent squint 9.9 GH1 PRL
21 vestibular gland benign neoplasm 9.9 PRL SST
22 glaucoma, hereditary adult type 1a 9.9 GH1 PRL
23 olfactory nerve neoplasm 9.9 GH1 PRL
24 osseous heteroplasia, progressive 9.9 GH1 PRL
25 plasmalogens synthesis deficiency isolated 9.9 GH1 PRL
26 leukemia, acute promyelocytic, somatic 9.9 PRL SST
27 cholesterol embolism 9.9 PRL TSHB
28 diencephalic neoplasm 9.9 GH1 PRL
29 adult i blood group with or without congenital cataract 9.9 GH1 PRL
30 anisometropia 9.9 GH1 SST
31 capillary lymphangioma 9.9 GH1 PRL
32 cervix squamous papilloma 9.9 GH1 PRL
33 hypothyroidism 9.8
34 adenoma 9.8
35 body dysmorphic disorder 9.8 PRL SST
36 protein s deficiency 9.8 GH1 PRL SST
37 caudal regression syndrome 9.8 GH1 PRL TSHB
38 pulmonary neuroendocrine tumor 9.8 GH1 PRL SST
39 infections, recurrent, with encephalopathy, hepatic dysfunction, and cardiovasuclar malformations 9.8 GH1 PRL SST
40 hemolytic anemia, cd59-mediated, with or without immune-mediated polyneuropathy 9.8 GH1 PRL
41 axial osteomalacia 9.8 GH1 PRL SST
42 mucopolysaccharidosis type vi 9.8 GH1 PRL TSHB
43 urethra clear cell adenocarcinoma 9.8 GH1 PRL SST
44 bile acid synthesis defect, congenital, 4 9.8 GH1 PRL SST
45 cold-induced sweating syndrome 2 9.8 GH1 PRL SST
46 glomangiomyoma 9.8 GH1 PRL SST
47 thrombophilia 9.7 GH1 PRL SST
48 edict syndrome 9.7 GH1 PRL SST
49 bladder colonic type adenocarcinoma 9.7 GH1 PRL SST
50 cerebral hemisphere lipoma 9.6 GH1 PRL SST TSHB

Graphical network of the top 20 diseases related to Tsh Producing Pituitary Tumor:



Diseases related to Tsh Producing Pituitary Tumor

Symptoms & Phenotypes for Tsh Producing Pituitary Tumor

Human phenotypes related to Tsh Producing Pituitary Tumor:

56 32 (show top 50) (show all 67)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 fatigue 56 32 Frequent (79-30%) HP:0012378
2 headache 56 32 Frequent (79-30%) HP:0002315
3 seizures 56 32 Occasional (29-5%) HP:0001250
4 vertigo 56 32 Occasional (29-5%) HP:0002321
5 tremor 56 32 Frequent (79-30%) HP:0001337
6 vomiting 56 32 Frequent (79-30%) HP:0002013
7 ptosis 56 32 Occasional (29-5%) HP:0000508
8 diplopia 56 32 Occasional (29-5%) HP:0000651
9 hypertension 56 32 Occasional (29-5%) HP:0000822
10 osteopenia 56 32 Frequent (79-30%) HP:0000938
11 hyperhidrosis 56 32 Frequent (79-30%) HP:0000975
12 hypotension 56 32 Frequent (79-30%) HP:0002615
13 blindness 56 32 Occasional (29-5%) HP:0000618
14 delayed puberty 56 32 Occasional (29-5%) HP:0000823
15 hypokalemia 56 32 Occasional (29-5%) HP:0002900
16 osteoporosis 56 32 Frequent (79-30%) HP:0000939
17 pallor 56 32 Frequent (79-30%) HP:0000980
18 weight loss 56 32 Frequent (79-30%) HP:0001824
19 congestive heart failure 56 32 Occasional (29-5%) HP:0001635
20 progressive visual loss 56 32 Frequent (79-30%) HP:0000529
21 increased circulating gonadotropin level 56 32 Occasional (29-5%) HP:0000837
22 hypogonadotrophic hypogonadism 56 32 Frequent (79-30%) HP:0000044
23 goiter 56 32 Very frequent (99-80%) HP:0000853
24 male hypogonadism 56 32 Frequent (79-30%) HP:0000026
25 growth hormone excess 56 32 Occasional (29-5%) HP:0000845
26 abnormality of the menstrual cycle 56 32 Frequent (79-30%) HP:0000140
27 gynecomastia 56 32 Frequent (79-30%) HP:0000771
28 infertility 56 32 Occasional (29-5%) HP:0000789
29 periodic hypokalemic paresis 56 32 Occasional (29-5%) HP:0008153
30 secondary growth hormone deficiency 56 32 Frequent (79-30%) HP:0008240
31 impotence 56 32 Frequent (79-30%) HP:0000802
32 decreased fertility in females 56 32 Frequent (79-30%) HP:0000868
33 decreased fertility in males 56 32 Frequent (79-30%) HP:0012041
34 female hypogonadism 56 32 Frequent (79-30%) HP:0000134
35 adrenocorticotropin deficient adrenal insufficiency 56 32 Frequent (79-30%) HP:0011735
36 adrenocorticotropic hormone deficiency 56 32 Frequent (79-30%) HP:0011748
37 decreased circulating acth level 56 32 Frequent (79-30%) HP:0002920
38 bitemporal hemianopia 56 32 Occasional (29-5%) HP:0030521
39 oculomotor nerve palsy 56 32 Occasional (29-5%) HP:0012246
40 prolactin excess 56 32 Occasional (29-5%) HP:0000870
41 cranial nerve vi palsy 56 32 Occasional (29-5%) HP:0006897
42 decreased female libido 56 32 Frequent (79-30%) HP:0030018
43 palpitations 56 32 Frequent (79-30%) HP:0001962
44 sudden loss of visual acuity 56 32 Occasional (29-5%) HP:0001117
45 easy fatigability 56 32 Frequent (79-30%) HP:0003388
46 fourth cranial nerve palsy 56 32 Occasional (29-5%) HP:0007011
47 internal ophthalmoplegia 56 32 Occasional (29-5%) HP:0007942
48 abnormality of hair density 56 32 Frequent (79-30%) HP:0011357
49 thyroid-stimulating hormone excess 56 32 Very frequent (99-80%) HP:0002925
50 enlarged pituitary gland 56 32 Very frequent (99-80%) HP:0012505

Drugs & Therapeutics for Tsh Producing Pituitary Tumor

Drugs for Tsh Producing Pituitary Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Octreotide Approved, Investigational Phase 3,Phase 1 83150-76-9 383414 6400441
2 Gastrointestinal Agents Phase 3,Phase 1
3 Edotreotide Phase 3,Phase 1
4 Radiopharmaceuticals Phase 3,Phase 1
5 Antineoplastic Agents, Hormonal Phase 3,Phase 1
6 Hormones Phase 2,Phase 1
7
Somatostatin Approved Phase 1 38916-34-6, 51110-01-1 53481605
8 pancreatic polypeptide Phase 1
9
Ursodeoxycholic acid Approved, Investigational 128-13-2 31401

Interventional clinical trials:


id Name Status NCT ID Phase
1 Ga-68-DOTATOC -PET in the Management of Pituitary Tumours Recruiting NCT02419664 Phase 3
2 Antineoplaston Therapy in Treating Patients With Neuroendocrine Tumor That Is Metastatic or Unlikely to Respond to Surgery or Radiation Therapy Withdrawn NCT00003514 Phase 2
3 Yttrium Y 90 SMT 487 in Treating Patients With Refractory or Recurrent Cancer Completed NCT00006368 Phase 1
4 Acute Side Effects in Patients Who Are Undergoing Stereotactic Radiosurgery for Brain Tumors or Other Brain Disorders Completed NCT00255671
5 The Treatment and Natural History of Acromegaly Recruiting NCT00001981

Search NIH Clinical Center for Tsh Producing Pituitary Tumor

Genetic Tests for Tsh Producing Pituitary Tumor

Anatomical Context for Tsh Producing Pituitary Tumor

MalaCards organs/tissues related to Tsh Producing Pituitary Tumor:

39
Pituitary, Thyroid, Testes, Heart

Publications for Tsh Producing Pituitary Tumor

Articles related to Tsh Producing Pituitary Tumor:

id Title Authors Year
1
A plurihormonal TSH-producing pituitary tumor of monoclonal origin in a patient with hypothyroidism. ( 12714791 )
2003
2
TSH producing pituitary tumor: biochemical diagnosis and long-term medical management with octreotide. ( 1612557 )
1992

Variations for Tsh Producing Pituitary Tumor

Cosmic variations for Tsh Producing Pituitary Tumor:

9
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA Conf
1 COSM22623 MEN1 pituitary,NS,adenoma,TSH c.1050-2A>G p.? 19

Expression for Tsh Producing Pituitary Tumor

Search GEO for disease gene expression data for Tsh Producing Pituitary Tumor.

Pathways for Tsh Producing Pituitary Tumor

GO Terms for Tsh Producing Pituitary Tumor

Cellular components related to Tsh Producing Pituitary Tumor according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.26 GH1 PRL SST TSHB
2 endosome lumen GO:0031904 8.62 GH1 PRL

Biological processes related to Tsh Producing Pituitary Tumor according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 response to estradiol GO:0032355 9.26 GH1 PRL
2 response to nutrient GO:0007584 9.16 PRL SST
3 positive regulation of JAK-STAT cascade GO:0046427 8.96 GH1 PRL
4 JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 8.62 GH1 PRL

Molecular functions related to Tsh Producing Pituitary Tumor according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 prolactin receptor binding GO:0005148 8.96 GH1 PRL
2 hormone activity GO:0005179 8.92 GH1 PRL SST TSHB

Sources for Tsh Producing Pituitary Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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