MCID: TSH001
MIFTS: 42

Tsh Producing Pituitary Tumor

Categories: Endocrine diseases, Rare diseases, Cancer diseases

Aliases & Classifications for Tsh Producing Pituitary Tumor

MalaCards integrated aliases for Tsh Producing Pituitary Tumor:

Name: Tsh Producing Pituitary Tumor 12 14
Thyrotroph Adenoma 12 55 69
Thyroid Stimulating Hormone-Secreting Pituitary Adenoma 55
Thyroid Stimulating Hormone-Producing Pituitary Tumor 69
Tsh Secreting Adenoma of the Pituitary 12
Tsh Secreting Tumor of Pituitary 12
Tsh-Secreting Pituitary Adenoma 55
Pituitary Thyrotrophic Adenoma 55
Tsh-Oma 55

Classifications:

Orphanet: 55  
Rare endocrine diseases


Summaries for Tsh Producing Pituitary Tumor

MalaCards based summary : Tsh Producing Pituitary Tumor, also known as thyrotroph adenoma, is related to pituitary tumors and hypothyroidism, and has symptoms including male hypogonadism, hypogonadotrophic hypogonadism and female hypogonadism. An important gene associated with Tsh Producing Pituitary Tumor is CDH23 (Cadherin Related 23), and among its related pathways/superpathways are Peptide ligand-binding receptors and Jak-STAT signaling pathway (KEGG). The drugs Octreotide and Antineoplastic Agents, Hormonal have been mentioned in the context of this disorder. Affiliated tissues include pituitary, thyroid and heart.

Related Diseases for Tsh Producing Pituitary Tumor

Diseases related to Tsh Producing Pituitary Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 44)
# Related Disease Score Top Affiliating Genes
1 pituitary tumors 29.6 GH1 PRL SST
2 hypothyroidism 29.3 PRL TSHB
3 adenoma 29.3 GH1 PRL SST
4 pituitary infarct 10.1 PRL SST
5 chiasmal syndrome 10.1 PRL SST
6 prolactin producing pituitary tumor 10.1 PRL SST
7 nelson syndrome 10.0 PRL SST
8 growth hormone secreting pituitary adenoma 10.0 PRL SST
9 fibrous dysplasia/mccune-albright syndrome 10.0 GH1 PRL
10 adrenal cortex disease 10.0 PRL SST
11 adrenal gland disease 10.0 PRL SST
12 non-functioning pituitary adenoma 10.0 GH1 SST
13 adenohypophysitis 10.0 GH1 PRL
14 thyroid gland disease 10.0 PRL TSHB
15 pseudohypoparathyroidism, type ia 10.0 GH1 PRL
16 hypothalamic disease 10.0 GH1 PRL
17 pituitary-dependent cushing's disease 10.0 PRL SST
18 gigantism 10.0 GH1 PRL
19 empty sella syndrome 10.0 GH1 PRL
20 endocrine organ benign neoplasm 10.0 PRL SST
21 tetrahydrobiopterin deficiency 10.0 GH1 PRL
22 organ system benign neoplasm 9.9 PRL SST
23 pituitary stalk interruption syndrome 9.9 GH1 PRL
24 chromophobe adenoma 9.9 GH1 PRL
25 cell type benign neoplasm 9.9 PRL SST
26 hypopituitarism 9.8 GH1 PRL
27 multiple endocrine neoplasia, type i 9.8 PRL SST
28 bulimia nervosa 2 9.8 GH1 PRL
29 acquired metabolic disease 9.7 PRL SST
30 hypothyroidism, congenital, nongoitrous, 4 9.7 GH1 PRL TSHB
31 pituitary hormone deficiency, combined, 2 9.7 GH1 PRL TSHB
32 pituitary adenoma 1, multiple types 9.7 GH1 PRL SST
33 hyperpituitarism 9.7 GH1 PRL SST
34 functioning pituitary adenoma 9.7 GH1 PRL SST
35 mccune-albright syndrome 9.7 GH1 PRL SST
36 fibrous dysplasia 9.7 GH1 PRL SST
37 adrenal gland hyperfunction 9.7 GH1 PRL SST
38 pituitary gland disease 9.6 GH1 PRL SST
39 hyperprolactinemia 9.6 GH1 PRL SST
40 acromegaly 9.6 GH1 PRL SST
41 hyperthyroidism 9.6 GH1 PRL SST
42 insulin-like growth factor i 9.6 GH1 PRL SST
43 pituitary adenoma 9.3 GH1 PRL SST TSHB
44 pituitary adenoma, prolactin-secreting 9.1 CDH23 GH1 PRL SST

Graphical network of the top 20 diseases related to Tsh Producing Pituitary Tumor:



Diseases related to Tsh Producing Pituitary Tumor

Symptoms & Phenotypes for Tsh Producing Pituitary Tumor

Human phenotypes related to Tsh Producing Pituitary Tumor:

55 31 (show top 50) (show all 68)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 male hypogonadism 55 31 frequent (33%) Frequent (79-30%) HP:0000026
2 hypogonadotrophic hypogonadism 55 31 frequent (33%) Frequent (79-30%) HP:0000044
3 female hypogonadism 55 31 frequent (33%) Frequent (79-30%) HP:0000134
4 abnormality of the menstrual cycle 55 31 frequent (33%) Frequent (79-30%) HP:0000140
5 ptosis 55 31 occasional (7.5%) Occasional (29-5%) HP:0000508
6 progressive visual loss 55 31 frequent (33%) Frequent (79-30%) HP:0000529
7 blindness 55 31 occasional (7.5%) Occasional (29-5%) HP:0000618
8 diplopia 55 31 occasional (7.5%) Occasional (29-5%) HP:0000651
9 gynecomastia 55 31 frequent (33%) Frequent (79-30%) HP:0000771
10 infertility 55 31 occasional (7.5%) Occasional (29-5%) HP:0000789
11 impotence 55 31 frequent (33%) Frequent (79-30%) HP:0000802
12 hypertension 55 31 occasional (7.5%) Occasional (29-5%) HP:0000822
13 delayed puberty 55 31 occasional (7.5%) Occasional (29-5%) HP:0000823
14 increased circulating gonadotropin level 55 31 occasional (7.5%) Occasional (29-5%) HP:0000837
15 growth hormone excess 55 31 occasional (7.5%) Occasional (29-5%) HP:0000845
16 decreased fertility in females 55 31 frequent (33%) Frequent (79-30%) HP:0000868
17 goiter 55 31 hallmark (90%) Very frequent (99-80%) HP:0000853
18 prolactin excess 55 31 occasional (7.5%) Occasional (29-5%) HP:0000870
19 osteopenia 55 31 frequent (33%) Frequent (79-30%) HP:0000938
20 osteoporosis 55 31 frequent (33%) Frequent (79-30%) HP:0000939
21 hyperhidrosis 55 31 frequent (33%) Frequent (79-30%) HP:0000975
22 pallor 55 31 frequent (33%) Frequent (79-30%) HP:0000980
23 sudden loss of visual acuity 55 31 occasional (7.5%) Occasional (29-5%) HP:0001117
24 seizures 55 31 occasional (7.5%) Occasional (29-5%) HP:0001250
25 tremor 55 31 frequent (33%) Frequent (79-30%) HP:0001337
26 headache 55 31 frequent (33%) Frequent (79-30%) HP:0002315
27 congestive heart failure 55 31 occasional (7.5%) Occasional (29-5%) HP:0001635
28 pericardial effusion 55 31 occasional (7.5%) Occasional (29-5%) HP:0001698
29 weight loss 55 31 frequent (33%) Frequent (79-30%) HP:0001824
30 palpitations 55 31 frequent (33%) Frequent (79-30%) HP:0001962
31 vomiting 55 31 frequent (33%) Frequent (79-30%) HP:0002013
32 vertigo 55 31 occasional (7.5%) Occasional (29-5%) HP:0002321
33 hypotension 55 31 frequent (33%) Frequent (79-30%) HP:0002615
34 hypokalemia 55 31 occasional (7.5%) Occasional (29-5%) HP:0002900
35 decreased circulating acth level 55 31 frequent (33%) Frequent (79-30%) HP:0002920
36 easy fatigability 55 31 frequent (33%) Frequent (79-30%) HP:0003388
37 ventricular arrhythmia 55 31 occasional (7.5%) Occasional (29-5%) HP:0004308
38 supraventricular arrhythmia 55 31 occasional (7.5%) Occasional (29-5%) HP:0005115
39 cranial nerve vi palsy 55 31 occasional (7.5%) Occasional (29-5%) HP:0006897
40 fourth cranial nerve palsy 55 31 occasional (7.5%) Occasional (29-5%) HP:0007011
41 internal ophthalmoplegia 55 31 occasional (7.5%) Occasional (29-5%) HP:0007942
42 periodic hypokalemic paresis 55 31 occasional (7.5%) Occasional (29-5%) HP:0008153
43 euthyroid hyperthyroxinemia 55 31 occasional (7.5%) Occasional (29-5%) HP:0008247
44 secondary growth hormone deficiency 55 31 frequent (33%) Frequent (79-30%) HP:0008240
45 abnormality of hair density 55 31 frequent (33%) Frequent (79-30%) HP:0011357
46 adrenocorticotropin deficient adrenal insufficiency 55 31 frequent (33%) Frequent (79-30%) HP:0011735
47 adrenocorticotropic hormone deficiency 55 31 frequent (33%) Frequent (79-30%) HP:0011748
48 thyroid crisis 55 31 frequent (33%) Frequent (79-30%) HP:0011782
49 decreased fertility in males 55 31 frequent (33%) Frequent (79-30%) HP:0012041
50 oculomotor nerve palsy 55 31 occasional (7.5%) Occasional (29-5%) HP:0012246

Drugs & Therapeutics for Tsh Producing Pituitary Tumor

Drugs for Tsh Producing Pituitary Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Octreotide Approved, Investigational Phase 3,Phase 1 83150-76-9 6400441 383414
2 Antineoplastic Agents, Hormonal Phase 3,Phase 1
3 Edotreotide Phase 3,Phase 1
4 Gastrointestinal Agents Phase 3,Phase 1
5 Radiopharmaceuticals Phase 3,Phase 1
6 Hormones Phase 2,Phase 1
7
Somatostatin Approved, Investigational Phase 1 38916-34-6, 51110-01-1 53481605
8 Pancreatic Polypeptide Investigational Phase 1 59763-91-6

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Ga-68-DOTATOC -PET in the Management of Pituitary Tumours Recruiting NCT02419664 Phase 3
2 Antineoplaston Therapy in Treating Patients With Neuroendocrine Tumor That Is Metastatic or Unlikely to Respond to Surgery or Radiation Therapy Withdrawn NCT00003514 Phase 2 antineoplaston A10;antineoplaston AS2-1
3 Yttrium Y 90 SMT 487 in Treating Patients With Refractory or Recurrent Cancer Completed NCT00006368 Phase 1
4 Acute Side Effects in Patients Who Are Undergoing Stereotactic Radiosurgery for Brain Tumors or Other Brain Disorders Completed NCT00255671

Search NIH Clinical Center for Tsh Producing Pituitary Tumor

Genetic Tests for Tsh Producing Pituitary Tumor

Anatomical Context for Tsh Producing Pituitary Tumor

MalaCards organs/tissues related to Tsh Producing Pituitary Tumor:

38
Pituitary, Thyroid, Heart, Testes, Brain

Publications for Tsh Producing Pituitary Tumor

Articles related to Tsh Producing Pituitary Tumor:

# Title Authors Year
1
A plurihormonal TSH-producing pituitary tumor of monoclonal origin in a patient with hypothyroidism. ( 12714791 )
2003
2
TSH producing pituitary tumor: biochemical diagnosis and long-term medical management with octreotide. ( 1612557 )
1992

Variations for Tsh Producing Pituitary Tumor

Cosmic variations for Tsh Producing Pituitary Tumor:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA Conf
1 COSM22623 MEN1 pituitary,NS,adenoma,TSH c.1050-2A>G p.? 19

Expression for Tsh Producing Pituitary Tumor

Search GEO for disease gene expression data for Tsh Producing Pituitary Tumor.

Pathways for Tsh Producing Pituitary Tumor

GO Terms for Tsh Producing Pituitary Tumor

Cellular components related to Tsh Producing Pituitary Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.26 GH1 PRL SST TSHB
2 endosome lumen GO:0031904 8.62 GH1 PRL

Biological processes related to Tsh Producing Pituitary Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of JAK-STAT cascade GO:0046427 9.16 GH1 PRL
2 JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 8.96 GH1 PRL
3 regulation of receptor activity GO:0010469 8.92 GH1 PRL SST TSHB

Molecular functions related to Tsh Producing Pituitary Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 prolactin receptor binding GO:0005148 8.96 GH1 PRL
2 hormone activity GO:0005179 8.92 GH1 PRL SST TSHB

Sources for Tsh Producing Pituitary Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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