MCID: TSH001
MIFTS: 39

Tsh Producing Pituitary Tumor

Categories: Endocrine diseases, Rare diseases, Cancer diseases

Aliases & Classifications for Tsh Producing Pituitary Tumor

MalaCards integrated aliases for Tsh Producing Pituitary Tumor:

Name: Tsh Producing Pituitary Tumor 12 14
Thyrotroph Adenoma 12 56 69
Thyroid Stimulating Hormone-Secreting Pituitary Adenoma 56
Thyroid Stimulating Hormone-Producing Pituitary Tumor 69
Tsh Secreting Adenoma of the Pituitary 12
Tsh Secreting Tumor of Pituitary 12
Tsh-Secreting Pituitary Adenoma 56
Pituitary Thyrotrophic Adenoma 56
Tsh-Oma 56

Classifications:

Orphanet: 56  
Rare endocrine diseases


Summaries for Tsh Producing Pituitary Tumor

MalaCards based summary : Tsh Producing Pituitary Tumor, also known as thyrotroph adenoma, is related to pituitary adenoma and african histoplasmosis, and has symptoms including male hypogonadism, hypogonadotrophic hypogonadism and female hypogonadism. An important gene associated with Tsh Producing Pituitary Tumor is CDH23 (Cadherin Related 23), and among its related pathways/superpathways are Peptide ligand-binding receptors and Peptide hormone metabolism. The drugs Octreotide and Antineoplastic Agents, Hormonal have been mentioned in the context of this disorder. Affiliated tissues include pituitary, thyroid and heart.

Related Diseases for Tsh Producing Pituitary Tumor

Diseases related to Tsh Producing Pituitary Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 49)
id Related Disease Score Top Affiliating Genes
1 pituitary adenoma 10.6
2 african histoplasmosis 10.2 PRL SST
3 lymphoepithelioma-like carcinoma 10.2 PRL SST
4 water-clear cell adenoma 10.2 PRL SST
5 actinobacillosis 10.1 PRL SST
6 g6pc3 deficiency 10.1 GH1 PRL
7 trabecular follicular adenocarcinoma 10.1 PRL SST
8 simple cryoglobulinemia 10.1 GH1 SST
9 bronchiectasis 10.1 PRL SST
10 aortic valve atresia 10.1 GH1 PRL
11 intermittent squint 10.1 GH1 PRL
12 fibrolamellar carcinoma 10.1 PRL TSHB
13 cardiovascular organ benign neoplasm 10.1 PRL SST
14 lactic acidosis 10.1 GH1 PRL
15 glassy cell carcinoma of the cervix 10.0 GH1 PRL
16 acute myocarditis 10.0 PRL SST
17 pityriasis rotunda 10.0 GH1 PRL
18 osseous heteroplasia, progressive 10.0 GH1 PRL
19 47,xyy syndrome 10.0 GH1 PRL
20 pituitary tumors 10.0
21 diencephalic neoplasm 10.0 GH1 PRL
22 vestibular gland benign neoplasm 10.0 PRL SST
23 male reproductive organ benign neoplasm 9.9 PRL SST
24 acute myeloid leukemia, susceptibility, gata2-related 9.9 GH1 PRL
25 cholesterol embolism 9.9 PRL TSHB
26 hypothyroidism 9.8
27 adenoma 9.8
28 immunodeficiency, common variable, 5 9.8 PRL SST
29 allergic asthma 9.8 GH1 PRL
30 survival motor neuron spinal muscular atrophy 9.7 PRL SST
31 hypothyroidism, congenital, nongoitrous 4 9.7 GH1 PRL TSHB
32 molybdenum cofactor deficiency b 9.7 GH1 PRL TSHB
33 protein s deficiency 9.6 GH1 PRL SST
34 strabismus 9.6 GH1 PRL SST
35 worth's syndrome 9.6 GH1 PRL SST
36 adrenal cortex disease 9.6 GH1 PRL SST
37 uterine ligament clear cell adenocarcinoma 9.6 GH1 PRL SST
38 alpha-methylacyl-coa racemase deficiency 9.6 GH1 PRL SST
39 skin meningioma 9.6 GH1 PRL SST
40 lung cancer susceptibility 2 9.6 GH1 PRL SST
41 childhood optic nerve glioma 9.5 GH1 PRL SST
42 chromosome 11p13 deletion syndrome, distal 9.4 GH1 PRL
43 psychogenic movement 9.2 GH1 PRL SST TSHB
44 pituitary adenoma, prolactin-secreting 8.8 CDH23 GH1 PRL SST
45 cold-induced sweating syndrome 2 8.8 CDH23 GH1 PRL SST
46 pituitary adenoma, acth-secreting 8.8 CDH23 GH1 PRL SST
47 thrombophilia 8.8 CDH23 GH1 PRL SST
48 combined t cell and b cell immunodeficiency 8.3 CDH23 GH1 PRL SST TSHB
49 usher syndrome, type 1f 8.3 CDH23 GH1 PRL SST TSHB

Graphical network of the top 20 diseases related to Tsh Producing Pituitary Tumor:



Diseases related to Tsh Producing Pituitary Tumor

Symptoms & Phenotypes for Tsh Producing Pituitary Tumor

Human phenotypes related to Tsh Producing Pituitary Tumor:

56 32 (show top 50) (show all 68)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 male hypogonadism 56 32 frequent (33%) Frequent (79-30%) HP:0000026
2 hypogonadotrophic hypogonadism 56 32 frequent (33%) Frequent (79-30%) HP:0000044
3 female hypogonadism 56 32 frequent (33%) Frequent (79-30%) HP:0000134
4 abnormality of the menstrual cycle 56 32 frequent (33%) Frequent (79-30%) HP:0000140
5 ptosis 56 32 occasional (7.5%) Occasional (29-5%) HP:0000508
6 progressive visual loss 56 32 frequent (33%) Frequent (79-30%) HP:0000529
7 blindness 56 32 occasional (7.5%) Occasional (29-5%) HP:0000618
8 diplopia 56 32 occasional (7.5%) Occasional (29-5%) HP:0000651
9 gynecomastia 56 32 frequent (33%) Frequent (79-30%) HP:0000771
10 infertility 56 32 occasional (7.5%) Occasional (29-5%) HP:0000789
11 impotence 56 32 frequent (33%) Frequent (79-30%) HP:0000802
12 hypertension 56 32 occasional (7.5%) Occasional (29-5%) HP:0000822
13 delayed puberty 56 32 occasional (7.5%) Occasional (29-5%) HP:0000823
14 increased circulating gonadotropin level 56 32 occasional (7.5%) Occasional (29-5%) HP:0000837
15 growth hormone excess 56 32 occasional (7.5%) Occasional (29-5%) HP:0000845
16 decreased fertility in females 56 32 frequent (33%) Frequent (79-30%) HP:0000868
17 goiter 56 32 hallmark (90%) Very frequent (99-80%) HP:0000853
18 prolactin excess 56 32 occasional (7.5%) Occasional (29-5%) HP:0000870
19 osteopenia 56 32 frequent (33%) Frequent (79-30%) HP:0000938
20 osteoporosis 56 32 frequent (33%) Frequent (79-30%) HP:0000939
21 hyperhidrosis 56 32 frequent (33%) Frequent (79-30%) HP:0000975
22 pallor 56 32 frequent (33%) Frequent (79-30%) HP:0000980
23 sudden loss of visual acuity 56 32 occasional (7.5%) Occasional (29-5%) HP:0001117
24 seizures 56 32 occasional (7.5%) Occasional (29-5%) HP:0001250
25 tremor 56 32 frequent (33%) Frequent (79-30%) HP:0001337
26 headache 56 32 frequent (33%) Frequent (79-30%) HP:0002315
27 congestive heart failure 56 32 occasional (7.5%) Occasional (29-5%) HP:0001635
28 pericardial effusion 56 32 occasional (7.5%) Occasional (29-5%) HP:0001698
29 weight loss 56 32 frequent (33%) Frequent (79-30%) HP:0001824
30 palpitations 56 32 frequent (33%) Frequent (79-30%) HP:0001962
31 vomiting 56 32 frequent (33%) Frequent (79-30%) HP:0002013
32 vertigo 56 32 occasional (7.5%) Occasional (29-5%) HP:0002321
33 hypotension 56 32 frequent (33%) Frequent (79-30%) HP:0002615
34 hypokalemia 56 32 occasional (7.5%) Occasional (29-5%) HP:0002900
35 decreased circulating acth level 56 32 frequent (33%) Frequent (79-30%) HP:0002920
36 easy fatigability 56 32 frequent (33%) Frequent (79-30%) HP:0003388
37 ventricular arrhythmia 56 32 occasional (7.5%) Occasional (29-5%) HP:0004308
38 supraventricular arrhythmia 56 32 occasional (7.5%) Occasional (29-5%) HP:0005115
39 cranial nerve vi palsy 56 32 occasional (7.5%) Occasional (29-5%) HP:0006897
40 fourth cranial nerve palsy 56 32 occasional (7.5%) Occasional (29-5%) HP:0007011
41 internal ophthalmoplegia 56 32 occasional (7.5%) Occasional (29-5%) HP:0007942
42 periodic hypokalemic paresis 56 32 occasional (7.5%) Occasional (29-5%) HP:0008153
43 euthyroid hyperthyroxinemia 56 32 occasional (7.5%) Occasional (29-5%) HP:0008247
44 secondary growth hormone deficiency 56 32 frequent (33%) Frequent (79-30%) HP:0008240
45 abnormality of hair density 56 32 frequent (33%) Frequent (79-30%) HP:0011357
46 adrenocorticotropin deficient adrenal insufficiency 56 32 frequent (33%) Frequent (79-30%) HP:0011735
47 adrenocorticotropic hormone deficiency 56 32 frequent (33%) Frequent (79-30%) HP:0011748
48 thyroid crisis 56 32 frequent (33%) Frequent (79-30%) HP:0011782
49 decreased fertility in males 56 32 frequent (33%) Frequent (79-30%) HP:0012041
50 oculomotor nerve palsy 56 32 occasional (7.5%) Occasional (29-5%) HP:0012246

Drugs & Therapeutics for Tsh Producing Pituitary Tumor

Drugs for Tsh Producing Pituitary Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Octreotide Approved, Investigational Phase 3,Phase 1 83150-76-9 383414 6400441
2 Antineoplastic Agents, Hormonal Phase 3,Phase 1
3 Edotreotide Phase 3,Phase 1
4 Gastrointestinal Agents Phase 3,Phase 1
5 Radiopharmaceuticals Phase 3,Phase 1
6 Hormones Phase 2,Phase 1
7
Somatostatin Approved Phase 1 38916-34-6, 51110-01-1 53481605
8 Pancreatic Polypeptide Investigational Phase 1 59763-91-6
9
Ursodeoxycholic acid Approved, Investigational 128-13-2 31401

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Ga-68-DOTATOC -PET in the Management of Pituitary Tumours Recruiting NCT02419664 Phase 3
2 Antineoplaston Therapy in Treating Patients With Neuroendocrine Tumor That Is Metastatic or Unlikely to Respond to Surgery or Radiation Therapy Withdrawn NCT00003514 Phase 2 antineoplaston A10;antineoplaston AS2-1
3 Yttrium Y 90 SMT 487 in Treating Patients With Refractory or Recurrent Cancer Completed NCT00006368 Phase 1
4 Acute Side Effects in Patients Who Are Undergoing Stereotactic Radiosurgery for Brain Tumors or Other Brain Disorders Completed NCT00255671
5 The Treatment and Natural History of Acromegaly Recruiting NCT00001981

Search NIH Clinical Center for Tsh Producing Pituitary Tumor

Genetic Tests for Tsh Producing Pituitary Tumor

Anatomical Context for Tsh Producing Pituitary Tumor

MalaCards organs/tissues related to Tsh Producing Pituitary Tumor:

39
Pituitary, Thyroid, Heart, Testes, Brain

Publications for Tsh Producing Pituitary Tumor

Articles related to Tsh Producing Pituitary Tumor:

id Title Authors Year
1
A plurihormonal TSH-producing pituitary tumor of monoclonal origin in a patient with hypothyroidism. ( 12714791 )
2003
2
TSH producing pituitary tumor: biochemical diagnosis and long-term medical management with octreotide. ( 1612557 )
1992

Variations for Tsh Producing Pituitary Tumor

Cosmic variations for Tsh Producing Pituitary Tumor:

9
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA Conf
1 COSM22623 MEN1 pituitary,NS,adenoma,TSH c.1050-2A>G p.? 18

Expression for Tsh Producing Pituitary Tumor

Search GEO for disease gene expression data for Tsh Producing Pituitary Tumor.

Pathways for Tsh Producing Pituitary Tumor

GO Terms for Tsh Producing Pituitary Tumor

Cellular components related to Tsh Producing Pituitary Tumor according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.26 GH1 PRL SST TSHB
2 endosome lumen GO:0031904 8.62 GH1 PRL

Biological processes related to Tsh Producing Pituitary Tumor according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 positive regulation of JAK-STAT cascade GO:0046427 8.96 GH1 PRL
2 JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 8.62 GH1 PRL

Molecular functions related to Tsh Producing Pituitary Tumor according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 prolactin receptor binding GO:0005148 8.96 GH1 PRL
2 hormone activity GO:0005179 8.92 GH1 PRL SST TSHB

Sources for Tsh Producing Pituitary Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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