MCID: TBR006
MIFTS: 43

Tuberculoid Leprosy malady

Category: Infectious diseases

Aliases & Classifications for Tuberculoid Leprosy

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Aliases & Descriptions for Tuberculoid Leprosy:

Name: Tuberculoid Leprosy 11 13 68
Leprosy, Tuberculoid 39
Leprosy Tuberculoid 50
 
Smooth Leprosy 11
Type T Leprosy 11

Classifications:



External Ids:

Disease Ontology11 DOID:1025
ICD1030 A30.1
SNOMED-CT62 70143003
ICD9CM32 030.1
MeSH39 D015441

Summaries for Tuberculoid Leprosy

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Disease Ontology:11 A leprosy that results in one erythematous large plaque with well-defined borders that are elevated and that slope down into an atrophic center.

MalaCards based summary: Tuberculoid Leprosy, also known as leprosy, tuberculoid, is related to leprosy and thalassemia minor. An important gene associated with Tuberculoid Leprosy is CORO1A (Coronin 1A), and among its related pathways are OX40 Pathway and African trypanosomiasis. Affiliated tissues include skin, t cells and testes, and related mouse phenotypes are Decreased viability with paclitaxel and Decreased shRNA abundance (Z-score < -2).

Wikipedia:71 Tuberculoid leprosy is a skin condition characterized by solitary skin lesions that are asymmetrically... more...

Related Diseases for Tuberculoid Leprosy

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Diseases related to Tuberculoid Leprosy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 82)
idRelated DiseaseScoreTop Affiliating Genes
1leprosy11.3
2thalassemia minor10.2TGFB2, TGFB3
3legionaire disease10.2TGFB2, TGFB3
4intellectual developmental disorder with persistence of fetal hemoglobin10.2TGFB2, TGFB3
5geleophysic dysplasia 210.2TGFB1, TGFB2
6renal tubular transport disease10.2TGFB2, TGFB3
7tuberculosis10.2
8refractory celiac disease10.2IL10, TGFB1
9distal trisomy 14q10.1IFNG, TGFB1
10anhidrosis10.1BMP6, TGFB1
11vibratory urticaria10.1TGFB1, TGFB3
12gastroschisis abdominal wall defects, included10.1BMP6, IFNG
13papillary adenocarcinoma10.1IL10, TGFB1
14lubani-al saleh-teebi syndrome10.1TGFB1, TGFB2, TGFB3
15endemic typhus10.1TGFB1, TGFB2, TGFB3
16speech and communication disorders10.1BMP6, TGFB1, TGFB3
17spastic diplegia10.1IFNG, TGFB1
18leishmaniasis10.1
19brown shrimp allergy10.1IL10, TGFB1
20human venous malformation10.1BMP6, TGFB1, TGFB2
21asymptomatic neurosyphilis10.0IFNG, IL10
22severe combined immunodeficiency, t cell-negative, b-cell/natural killer-cell positive10.0IFNG, IL10
23tungiasis10.0IFNG, IL10
24lepromatous leprosy10.0
25neuritis10.0
26pulmonary tuberculosis10.0
27orbit alveolar rhabdomyosarcoma10.0IL10, TGFB1, TGFB2
28transient tic disorder10.0BMP6, IL10
29demyelinating polyneuropathy10.0BMP6, IL10, TGFB1
30exhibitionism10.0MLLT1, SDHD
31plantar wart10.0IFNG, IL10, TGFB1
32chronic thromboembolic pulmonary hypertension10.0IFNG, IL10, TGFB1
33loiasis10.0IFNG, IL10, TGFB1
34myiasis10.0IFNG, IL10, TGFB1
35burns9.9IFNG, IL10, TGFB1
36liver inflammatory pseudotumor9.9IFNG, IL10, TGFB1
37sclerosing adenosis of breast9.9IFNG, IL10, TGFB1
38pigmentation disease9.9IFNG, IL10, TGFB1
39bone angioendothelial sarcoma9.9IFNG, IL10, TGFB1
40detrusor sphincter dyssynergia9.9IFNG, IL10, TGFB1
41erythematosquamous dermatosis9.9IFNG, IL10, TGFB1
42acute chest syndrome9.9IFNG, IL10, TGFB1
43nervous system cancer9.9IFNG, IL10, TGFB1
44systemic lupus erythematosus9.9
45epidermodysplasia verruciformis9.9
46mycosis fungoides9.9
47lupus erythematosus9.9
48hansen's disease9.9
49childhood malignant hemangiopericytoma9.9IFNG, IL10, TGFB1
50ciliary discoordination, due to random ciliary orientation9.9IFNG, IL10

Graphical network of the top 20 diseases related to Tuberculoid Leprosy:



Diseases related to tuberculoid leprosy

Symptoms & Phenotypes for Tuberculoid Leprosy

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GenomeRNAi Phenotypes related to Tuberculoid Leprosy according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00293-A10.6IL10, TGFB1
2GR00366-A-848.1MLLT1, SDHD, TGFB2, HSPA1A, TGFB1, TGFB2

MGI Mouse Phenotypes related to Tuberculoid Leprosy according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053829.4IFNG, IL10, TGFB1, TGFB2, TGFB3
2MP:00053679.2CORO1A, IFNG, MLLT1, TGFB1, TGFB2
3MP:00020068.9IFNG, IL10, MLLT1, SDHD, TGFB1
4MP:00053798.6CORO1A, IFNG, IL10, SDHD, TGFB1, TGFB2
5MP:00053808.5IFNG, IL10, SDHD, TGFB1, TGFB2, TGFB3
6MP:00053978.5CORO1A, IFNG, IL10, MLLT1, TGFB1, TGFB2
7MP:00053878.5CORO1A, IFNG, IL10, MLLT1, TGFB1, TGFB2
8MP:00053907.9BMP6, IFNG, IL10, TGFB1, TGFB2, TGFB3

Drugs & Therapeutics for Tuberculoid Leprosy

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Tuberculoid Leprosy


Cochrane evidence based reviews: leprosy, tuberculoid

Genetic Tests for Tuberculoid Leprosy

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Anatomical Context for Tuberculoid Leprosy

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MalaCards organs/tissues related to Tuberculoid Leprosy:

36
Skin, T cells, Testes, Liver, Bone, Lymph node, Bone marrow

Publications for Tuberculoid Leprosy

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Articles related to Tuberculoid Leprosy:

(show top 50)    (show all 238)
idTitleAuthorsYear
1
Borderline Tuberculoid Leprosy Associated with Histoid Leprosy. (27688462)
2016
2
Autochthonous borderline tuberculoid leprosy in a man from Florida. (27255063)
2016
3
Perineural and intraneural cutaneous granulomas in granulomatous mycosis fungoides mimicking tuberculoid leprosy. (27653439)
2016
4
Surgical treatment of type I neuritis in a teenage boy with borderline tuberculoid leprosy. (25992943)
2015
5
Borderline tuberculoid leprosy in childhood onset systemic lupus erythematosus patient. (26113359)
2015
6
Tuberculoid leprosy presenting as a "racket" lesion. (26131879)
2015
7
Compound heterozygous CORO1A mutations in siblings with a mucocutaneous-immunodeficiency syndrome of epidermodysplasia verruciformis-HPV, molluscum contagiosum and granulomatous tuberculoid leprosy. (25073507)
2014
8
Tuberculoid leprosy presenting as unilateral big toe drop. (24451978)
2014
9
Tuberculoid leprosy revealed by active ulcerative colitis: a case report. (25152018)
2014
10
Borderline tuberculoid leprosy with scrofuloderma: an uncommon association. (25035384)
2014
11
Borderline tuberculoid leprosy with type 1/reversal reaction. (24481019)
2014
12
Sporotrichoid pattern of nerve abscesses in borderline tuberculoid leprosy: A Case Report (sporotrichoid like abscesses in leprosy). (26411249)
2014
13
Nerve conduction studies in early tuberculoid leprosy. (25593812)
2014
14
S-100 immunostaining in the Distinction of Borderline Tuberculoid Leprosy from other Cutaneous Granulomas. (25071276)
2014
15
Borderline tuberculoid leprosy and type 1 leprosy reaction in a hepatitis C patient during treatment with interferon and ribavirin. (24346894)
2013
16
Borderline tuberculoid leprosy mimicking mycosis fungoides. (24517048)
2013
17
Cutaneous and mucocutaneous leishmaniasis resembling borderline-tuberculoid leprosy: a new clinical presentation? (22434112)
2013
18
Extensive ulnar nerve necrosis: a complication of tuberculoid leprosy. (23741888)
2013
19
Post traumatic borderline tuberculoid leprosy over knee in an Indian male. (24428119)
2013
20
Borderline tuberculoid leprosy associated with primary cutaneous histoplasmosis. (22481668)
2012
21
Tuberculoid leprosy and cytomegalovirus retinitis as immune restoration disease in a patient with AIDS. (22169463)
2012
22
Trigeminal trophic syndrome complicating a case of borderline tuberculoid leprosy. (22655477)
2012
23
Clinical presentation of tuberculoid leprosy in an epidermodysplasia verruciformis patient. (22711134)
2012
24
Incidental Hailey-Hailey like acantholysis in a lesion of borderline tuberculoid leprosy. (23130240)
2011
25
Considered "negative" for MAP, these results would be very "positive" for tuberculoid leprosy. (21683311)
2011
26
Images in clinical medicine. Tuberculoid leprosy. (21524216)
2011
27
Facial tuberculoid leprosy: case report. (20188445)
2011
28
Lupus vulgaris and borderline tuberculoid leprosy: an interesting co-occurrence. (21220903)
2011
29
Presence of intestinal helminths decreases T helper type 1 responses in tuberculoid leprosy patients and may increase the risk for multi-bacillary leprosy. (20491787)
2010
30
Ornamental tattoos and skin lesions. Tattoo inoculation borderline tuberculoid leprosy. (19126044)
2009
31
Post-traumatic inoculation tuberculoid leprosy after injury with a glass bangle. (19743627)
2009
32
Question: Can you identify this condition? Tuberculoid leprosy. (19155370)
2009
33
Borderline tuberculoid leprosy with upgrading Type 1 reaction in a HIV seropositive patient, after antiretroviral therapy: an immune reconstitution inflammatory syndrome. (19472856)
2009
34
Total agranulocytosis caused by dapsone therapy for tuberculoid leprosy--an unappreciated serious side effect of anti-leprosy treatment with clinical implications. (20408505)
2009
35
Borderline tuberculoid leprosy--an unusual presentation: a case report. (19295116)
2008
36
Immune reconstitution inflammatory syndrome or upgrading type 1 reaction? Report of two AIDS patients presenting a shifting from borderline lepromatous leprosy to borderline tuberculoid leprosy. (19274990)
2008
37
Post-kala-azar dermal leishmaniasis and borderline tuberculoid leprosy. (18047513)
2008
38
Paracoccidioidomycosis: infiltrated, sarcoid-like cutaneous lesions misinterpreted as tuberculoid leprosy. (18327487)
2008
39
Leprosy type 1 reaction spares the scars in a patch of borderline tuberculoid leprosy. (18205873)
2008
40
Immunohistochemical analysis of the immune cells in the epithelioid cell granuloma of tuberculoid leprosy. (18086607)
2008
41
Tuberculoid leprosy and Type 1 lepra reaction. (18760255)
2008
42
Postkala-azar dermal leishmaniasis coexisting with borderline tuberculoid leprosy. (17627788)
2007
43
Borderline tuberculoid leprosy in a woman from the state of Georgia with armadillo exposure. (17010758)
2006
44
Greater auricular nerve abscess in borderline tuberculoid leprosy masquerading as jugular vein thrombosis. (17091546)
2006
45
Multiple superficial sporotrichoid nerve abscesses with a hyperpigmented lesion in a tuberculoid leprosy patient: a rare and unusual presentation. (16503914)
2006
46
S-100 as a useful auxiliary diagnostic aid in tuberculoid leprosy. (16872470)
2006
47
Borderline tuberculoid leprosy localised over a scar. (16044818)
2005
48
Distribution and density of mast cells in tuberculoid leprosy. (16173422)
2005
49
Bigger may not always be better: giant borderline tuberculoid leprosy lesion. (16038255)
2005
50
Borderline tuberculoid leprosy with type 1 reaction in an HIV patient--a phenomenon of immune reconstitution. (16830642)
2005

Variations for Tuberculoid Leprosy

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Expression for genes affiliated with Tuberculoid Leprosy

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Search GEO for disease gene expression data for Tuberculoid Leprosy.

Pathways for genes affiliated with Tuberculoid Leprosy

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Pathways related to Tuberculoid Leprosy according to GeneCards Suite gene sharing:

(show top 50)    (show all 52)
idSuper pathwaysScoreTop Affiliating Genes
19.8IFNG, IL10
29.8IFNG, IL10
39.8IFNG, TGFB1
49.7TGFB1, TGFB3
5
Show member pathways
9.7TGFB1, TGFB3
6
Show member pathways
9.6TGFB1, TGFB2
79.4IFNG, IL10, TGFB1
8
Show member pathways
9.4IFNG, IL10, TGFB1
99.4IFNG, IL10, TGFB1
109.4HSPA1A, IFNG, IL10
119.3IFNG, TGFB1, TGFB2
12
Show member pathways
9.2TGFB1, TGFB2, TGFB3
139.2TGFB1, TGFB2, TGFB3
14
Show member pathways
9.2TGFB1, TGFB2, TGFB3
159.2TGFB1, TGFB2, TGFB3
169.2TGFB1, TGFB2, TGFB3
179.2TGFB1, TGFB2, TGFB3
18
Show member pathways
9.2TGFB1, TGFB2, TGFB3
19
Show member pathways
9.2TGFB1, TGFB2, TGFB3
20
Show member pathways
9.2TGFB1, TGFB2, TGFB3
219.2TGFB1, TGFB2, TGFB3
229.2TGFB1, TGFB2, TGFB3
239.2TGFB1, TGFB2, TGFB3
24
Show member pathways
9.2TGFB1, TGFB2, TGFB3
259.1HSPA1A, TGFB1, TGFB2
269.1BMP6, IL10, TGFB3
27
Show member pathways
9.0HSPA1A, IFNG, IL10, TGFB1
289.0BMP6, TGFB1, TGFB2
298.9IFNG, TGFB1, TGFB2, TGFB3
308.9IFNG, TGFB1, TGFB2, TGFB3
31
Show member pathways
8.9IFNG, TGFB1, TGFB2, TGFB3
328.8IL10, TGFB1, TGFB2, TGFB3
33
Show member pathways
8.8IL10, TGFB1, TGFB2, TGFB3
34
Show member pathways
8.7HSPA1A, TGFB1, TGFB2, TGFB3
358.7HSPA1A, TGFB1, TGFB2, TGFB3
368.5BMP6, TGFB1, TGFB2, TGFB3
37
Show member pathways
8.5BMP6, TGFB1, TGFB2, TGFB3
388.5BMP6, TGFB1, TGFB2, TGFB3
398.5BMP6, TGFB1, TGFB2, TGFB3
408.5BMP6, TGFB1, TGFB2, TGFB3
418.5BMP6, TGFB1, TGFB2, TGFB3
42
Show member pathways
8.5IFNG, IL10, TGFB1, TGFB2, TGFB3
438.5IFNG, IL10, TGFB1, TGFB2, TGFB3
44
Show member pathways
8.5IFNG, IL10, TGFB1, TGFB2, TGFB3
458.5IFNG, IL10, TGFB1, TGFB2, TGFB3
46
Show member pathways
8.5IFNG, IL10, TGFB1, TGFB2, TGFB3
47
Show member pathways
8.2BMP6, IFNG, TGFB1, TGFB2, TGFB3
488.2CORO1A, IFNG, IL10, TGFB1, TGFB2, TGFB3
49
Show member pathways
8.2BMP6, IL10, TGFB1, TGFB2, TGFB3
50
Show member pathways
8.0HSPA1A, IFNG, IL10, TGFB1, TGFB2, TGFB3

GO Terms for genes affiliated with Tuberculoid Leprosy

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Cellular components related to Tuberculoid Leprosy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:00310939.2TGFB1, TGFB2, TGFB3
2extracellular spaceGO:00056158.4BMP6, IFNG, IL10, TGFB1, TGFB2, TGFB3
3extracellular regionGO:00055768.2BMP6, HSPA1A, IFNG, IL10, TGFB1, TGFB2

Biological processes related to Tuberculoid Leprosy according to GeneCards Suite gene sharing:

(show top 50)    (show all 61)
idNameGO IDScoreTop Affiliating Genes
1leukocyte chemotaxisGO:003059510.6CORO1A, IL10
2defense response to protozoanGO:004283210.6IFNG, IL10
3negative regulation of growth of symbiont in hostGO:004413010.6IFNG, IL10
4positive regulation of MHC class II biosynthetic processGO:004534810.6IFNG, IL10
5negative regulation of interleukin-17 productionGO:003270010.6IFNG, TGFB1
6liver regenerationGO:009742110.5IL10, TGFB1
7positive regulation of protein complex assemblyGO:003133410.5IFNG, TGFB1
8negative regulation of mitotic cell cycleGO:004593010.5IL10, TGFB1
9negative regulation of vascular smooth muscle cell proliferationGO:190470610.5IL10, TGFB3
10protein import into nucleus, translocationGO:000006010.5IFNG, TGFB1
11digestive tract developmentGO:004856510.5TGFB1, TGFB3
12frontal suture morphogenesisGO:006036410.5TGFB1, TGFB3
13mammary gland developmentGO:003087910.5TGFB1, TGFB3
14negative regulation of DNA replicationGO:000815610.5TGFB1, TGFB3
15ossification involved in bone remodelingGO:004393210.5TGFB1, TGFB3
16positive regulation of collagen biosynthetic processGO:003296710.5TGFB1, TGFB3
17T cell homeostasisGO:004302910.4CORO1A, TGFB1
18regulation of epithelial to mesenchymal transition involved in endocardial cushion formationGO:190500510.4TGFB1, TGFB3
19heart valve morphogenesisGO:000317910.4TGFB1, TGFB2
20negative regulation of immune responseGO:005077710.4TGFB1, TGFB2
21pathway-restricted SMAD protein phosphorylationGO:006038910.4TGFB1, TGFB2
22positive regulation of protein localization to nucleusGO:190018210.3TGFB1, TGFB2
23response to laminar fluid shear stressGO:003461610.3TGFB1, TGFB3
24odontogenesisGO:004247610.3TGFB2, TGFB3
25regulation of complement-dependent cytotoxicityGO:190365910.3IL10, TGFB2
26agingGO:000756810.1IL10, TGFB1, TGFB3
27eye developmentGO:000165410.1BMP6, TGFB2
28cell migrationGO:001647710.1CORO1A, TGFB1, TGFB2
29uterine wall breakdownGO:004270410.1TGFB2, TGFB3
30cell cycle arrestGO:000705010.1IFNG, TGFB1, TGFB2
31extrinsic apoptotic signaling pathwayGO:009719110.0IFNG, TGFB1, TGFB2
32negative regulation of gene expressionGO:001062910.0IFNG, TGFB1, TGFB2
33negative regulation of transforming growth factor beta receptor signaling pathwayGO:003051210.0HSPA1A, TGFB1, TGFB3
34cell developmentGO:004846810.0TGFB1, TGFB2, TGFB3
35cell growthGO:001604910.0TGFB1, TGFB2, TGFB3
36cell-cell junction organizationGO:004521610.0TGFB1, TGFB2, TGFB3
37face morphogenesisGO:006032510.0TGFB1, TGFB2, TGFB3
38inner ear developmentGO:004883910.0TGFB1, TGFB2, TGFB3
39negative regulation of macrophage cytokine productionGO:00109369.9TGFB1, TGFB2, TGFB3
40platelet degranulationGO:00025769.9TGFB1, TGFB2, TGFB3
41positive regulation of cell divisionGO:00517819.9TGFB1, TGFB2, TGFB3
42positive regulation of epithelial to mesenchymal transitionGO:00107189.9TGFB1, TGFB2, TGFB3
43negative regulation of cell growthGO:00303089.9HSPA1A, TGFB1, TGFB2
44positive regulation of bone mineralizationGO:00305019.8BMP6, TGFB1, TGFB3
45positive regulation of SMAD protein import into nucleusGO:00603919.8BMP6, TGFB1, TGFB3
46response to hypoxiaGO:00016669.8TGFB1, TGFB2, TGFB3
47response to progesteroneGO:00325709.8TGFB1, TGFB2, TGFB3
48salivary gland morphogenesisGO:00074359.8TGFB1, TGFB2, TGFB3
49SMAD protein import into nucleusGO:00071849.8TGFB1, TGFB2, TGFB3
50positive regulation of transcription, DNA-templatedGO:00458939.7IFNG, IL10, TGFB1, TGFB3

Molecular functions related to Tuberculoid Leprosy according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1type I transforming growth factor beta receptor bindingGO:00347139.9TGFB1, TGFB3
2type II transforming growth factor beta receptor bindingGO:00051149.2TGFB1, TGFB2, TGFB3
3type III transforming growth factor beta receptor bindingGO:00347149.2TGFB1, TGFB2, TGFB3
4protein heterodimerization activityGO:00469829.0BMP6, TGFB1, TGFB2, TGFB3
5transforming growth factor beta receptor bindingGO:00051608.9BMP6, TGFB1, TGFB2, TGFB3
6growth factor activityGO:00080838.9BMP6, IL10, TGFB1, TGFB2, TGFB3
7cytokine activityGO:00051258.6BMP6, IFNG, IL10, TGFB1, TGFB2, TGFB3

Sources for Tuberculoid Leprosy

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet