MCID: TBR006
MIFTS: 44

Tuberculoid Leprosy malady

Category: Infectious diseases

Aliases & Classifications for Tuberculoid Leprosy

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Aliases & Descriptions for Tuberculoid Leprosy:

Name: Tuberculoid Leprosy 11 13 67
Leprosy, Tuberculoid 38
Leprosy Tuberculoid 49
 
Smooth Leprosy 11
Type T Leprosy 11

Classifications:



External Ids:

Disease Ontology11 DOID:1025
ICD1029 A30.1
SNOMED-CT61 70143003
ICD9CM31 030.1
MeSH38 D015441

Summaries for Tuberculoid Leprosy

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Disease Ontology:11 A leprosy that results in one erythematous large plaque with well-defined borders that are elevated and that slope down into an atrophic center.

MalaCards based summary: Tuberculoid Leprosy, also known as leprosy, tuberculoid, is related to leprosy and diamond-blackfan anemia. An important gene associated with Tuberculoid Leprosy is IFNG (Interferon Gamma), and among its related pathways are IL12 signaling mediated by STAT4 and African trypanosomiasis. Affiliated tissues include skin, t cells and testes, and related mouse phenotypes are renal/urinary system and craniofacial.

Wikipedia:70 Tuberculoid leprosy is a skin condition characterized by solitary skin lesions that are asymmetrically... more...

Related Diseases for Tuberculoid Leprosy

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Diseases related to Tuberculoid Leprosy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 126)
idRelated DiseaseScoreTop Affiliating Genes
1leprosy11.3
2diamond-blackfan anemia10.5TGFB1, TGFB2
3acromicric dysplasia10.5TGFB1, TGFB2
4fibrosclerosis of breast10.5TGFB1, TGFB2
5hypohidrosis10.5BMP6, TGFB1
6tgfbr1-related loeys-dietz syndrome10.5TGFB2, TGFB3
7vitreous abscess10.4TGFB1, TGFB2
8loeys-dietz syndrome 410.4TGFB2, TGFB3
9renal clear cell carcinoma10.4TGFB2, TGFB3
10adenosine monophosphate deaminase deficiency erythrocyte type10.4TGFB2, TGFB3
11keratopathy10.4IFNG, TGFB1
12leukemia10.4TGFB1, TGFB2
13cholesteatoma of middle ear10.4IFNG, TGFB1
14tertiary neurosyphilis10.4IFNG, TGFB1
15naegeli-franceschetti-jadassohn syndrome/dermatopathia pigmentosa reticularis10.3BMP6, TGFB1
16gastroschisis abdominal wall defects, included10.3BMP6, IFNG
17papillary cystadenocarcinoma10.3IL10, TGFB1
18actinomycosis10.3BMP6, TGFB1
19crustacean allergy10.3IL10, TGFB1
20malignant neoplasm of acoustic nerve10.3IFNG, TGFB1
21burns10.2IL10, TGFB1
22renal cell carcinoma 410.2BMP6, IFNG
23holoprosencephaly10.2BMP6, TGFB1, TGFB2
24ethmoid sinus adenoid cystic carcinoma10.2BMP6, IL10
25twin-to-twin transfusion syndrome10.2TGFB1, TGFB2, TGFB3
26idiopathic corneal edema10.2TGFB1, TGFB2, TGFB3
2746 xy gonadal dysgenesis10.2TGFB1, TGFB2, TGFB3
28epidemic typhus10.2TGFB1, TGFB2, TGFB3
29tuberculosis10.2
30eye accommodation disease10.1IFNG, IL10
31thelaziasis10.1IFNG, IL10
32graft-versus-host disease, protection against10.1IFNG, IL10
33chronic hiccups10.1IFNG, IL10
34buruli ulcer10.1IFNG, IL10
35nelson syndrome10.1IFNG, IL10
36leishmaniasis10.1
37primary orthostatic tremor10.1IFNG, IL10
38herpangina10.1IFNG, IL10
39hernia of ovary and fallopian tube10.1IFNG, IL10
40orbit alveolar rhabdomyosarcoma10.1IFNG, IL10
41lipodermatosclerosis10.1IFNG, IL10
42meninges hemangiopericytoma10.1IFNG, IL10
43idiopathic neutropenia10.0IFNG, IL10
44pseudoretinitis pigmentosa10.0IFNG, IL10
45peanut allergy10.0IL10, TGFB1, TGFB2
46pneumonic tularemia10.0IFNG, IL10
47sensorineural hearing loss10.0IFNG, IL10
48scn8a encephalopathy10.0IFNG, IL10
49lepromatous leprosy10.0
50neuritis10.0

Graphical network of the top 20 diseases related to Tuberculoid Leprosy:



Diseases related to tuberculoid leprosy

Symptoms for Tuberculoid Leprosy

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Drugs & Therapeutics for Tuberculoid Leprosy

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Tuberculoid Leprosy


Cochrane evidence based reviews: leprosy, tuberculoid

Genetic Tests for Tuberculoid Leprosy

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Anatomical Context for Tuberculoid Leprosy

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MalaCards organs/tissues related to Tuberculoid Leprosy:

35
Skin, T cells, Testes, Liver, Bone, Lymph node, Bone marrow

Animal Models for Tuberculoid Leprosy or affiliated genes

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MGI Mouse Phenotypes related to Tuberculoid Leprosy:

40 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053679.3CORO1A, IFNG, MLLT1, TGFB1, TGFB2
2MP:00053829.3IFNG, IL10, TGFB1, TGFB2, TGFB3
3MP:00053819.2IFNG, IL10, TGFB1, TGFB2, TGFB3
4MP:00053889.2IFNG, IL10, TGFB1, TGFB2, TGFB3
5MP:00020068.9IFNG, IL10, MLLT1, SDHD, TGFB1
6MP:00053798.7CORO1A, IFNG, IL10, SDHD, TGFB1, TGFB2
7MP:00053808.4IFNG, IL10, SDHD, TGFB1, TGFB2, TGFB3
8MP:00053848.2CORO1A, IFNG, IL10, SDHD, TGFB1, TGFB2
9MP:00053907.9BMP6, IFNG, IL10, TGFB1, TGFB2, TGFB3

Publications for Tuberculoid Leprosy

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Articles related to Tuberculoid Leprosy:

(show top 50)    (show all 238)
idTitleAuthorsYear
1
Borderline tuberculoid leprosy with scrofuloderma: an uncommon association. (25035384)
2014
2
Sporotrichoid pattern of nerve abscesses in borderline tuberculoid leprosy: A Case Report (sporotrichoid like abscesses in leprosy). (26411249)
2014
3
Borderline tuberculoid leprosy and type 1 leprosy reaction in a hepatitis C patient during treatment with interferon and ribavirin. (24346894)
2013
4
Borderline tuberculoid leprosy mimicking mycosis fungoides. (24517048)
2013
5
Clinical presentation of tuberculoid leprosy in an epidermodysplasia verruciformis patient. (22711134)
2012
6
Post-traumatic inoculation tuberculoid leprosy after injury with a glass bangle. (19743627)
2009
7
Borderline tuberculoid leprosy--an unusual presentation: a case report. (19295116)
2008
8
Immune reconstitution inflammatory syndrome or upgrading type 1 reaction? Report of two AIDS patients presenting a shifting from borderline lepromatous leprosy to borderline tuberculoid leprosy. (19274990)
2008
9
Greater auricular nerve abscess in borderline tuberculoid leprosy masquerading as jugular vein thrombosis. (17091546)
2006
10
Borderline tuberculoid leprosy in a woman from the state of Georgia with armadillo exposure. (17010758)
2006
11
Borderline tuberculoid leprosy with type 1 reaction in an HIV patient--a phenomenon of immune reconstitution. (16830642)
2005
12
Borderline tuberculoid leprosy localised over a scar. (16044818)
2005
13
Tuberculoid leprosy confined to glans penis in two cases. (15282972)
2004
14
A case of post-partum borderline tuberculoid leprosy complicated by a median nerve abscess, peptic ulceration and rifampicin-induced haemolytic renal failure. (15282971)
2004
15
Cutaneous granulomas masquerading as tuberculoid leprosy in a patient with congenital combined immunodeficiency. (11514920)
2001
16
Pathologic changes in a tibial nerve with surviving M. leprae in a healed tuberculoid leprosy patient. (9207758)
1997
17
Electro neuro physiological studies in early tuberculoid leprosy. (8345232)
1993
18
Tuberculoid leprosy--an unusual presentation. (2086689)
1990
19
Mycobacterium leprae-specific T cells from a tuberculoid leprosy patient suppress HLA-DR3-restricted T cell responses to an immunodominant epitope on 65-kDa hsp of mycobacteria. (1701000)
1990
20
Psoralene in repigmentation of tuberculoid leprosy. (2625362)
1989
21
Destruction of ala nasi and loss of columella in borderline tuberculoid leprosy--a case report. (2703741)
1989
22
Calcification of ulnar nerve in a patient with tuberculoid leprosy--a case report. (2539417)
1989
23
A follow up study of borderline tuberculoid leprosy under sulphone monotherapy. (3204273)
1988
24
Photoactivated topical 8-methoxypsoralen in repigmentation of a tuberculoid leprosy lesion. (3373082)
1988
25
Tuberculoid leprosy in Mexicans is associated with HLA-DR3. (3501513)
1987
26
Subpolar tuberculoid leprosy. (3440846)
1987
27
Melkersson-Rosenthal syndrome masquerading as tuberculoid leprosy. (3611858)
1987
28
Six cases of dapsone-resistant tuberculoid leprosy. (6399070)
1984
29
Clinical electrophysiologic assessment of ulnar nerve transposition in tuberculoid leprosy. (6642835)
1983
30
In vitro lymphocyte stimulation in an approach to study the expression of HLA-encoded genes predisposing to tuberculoid leprosy. (6408015)
1983
31
The pathogenesis and classification of polar tuberculoid leprosy]. (7078339)
1982
32
Serum enzyme profile in tuberculoid leprosy. (7098444)
1982
33
Nerve damage in tuberculoid leprosy. (7132297)
1982
34
Tuberculoid leprosy and HLA in Japanese. (6953616)
1981
35
Borderline tuberculoid leprosy following BCG vaccination. A case report. (7195879)
1981
36
Variation of in vitro lymphocyte responses to M. leprae antigen in borderline tuberculoid leprosy patients. (6154019)
1980
37
Some aspects of tuberculoid leprosy and chemotherapeutic trials. (116471)
1979
38
Mycobacterium leprae in the striated muscle of tuberculoid leprosy patients. (359926)
1978
39
Tuberculoid leprosy: a neurologic case report. (4504012)
1972
40
Trial of high dosages of dapsone in the treatment of tuberculoid leprosy. (5150030)
1971
41
Phenoloxidase activity in organisms isolated from lepromatous and tuberculoid leprosy. (16559125)
1970
42
Fate of Mycobacterium leprae in macrophages of patients with lepromatous or tuberculoid leprosy. (4929374)
1970
43
Solitary neural tuberculoid leprosy. (4298827)
1968
44
Pure neural tuberculoid leprosy. (4283894)
1965
45
THE ROLE OF PYRAZON IN REACTIONS IN TUBERCULOID LEPROSY. (14282489)
1964
46
Tuberculoid leprosy in identical twins. (13515394)
1958
47
Primary and secondary tuberculoid leprosy. (13405586)
1956
48
Tuberculoid leprosy. (13091392)
1953
49
Tuberculoid leprosy of lupoid appearance. (20292635)
1947
50
Tuberculoid leprosy. (21065780)
1946

Variations for Tuberculoid Leprosy

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Expression for genes affiliated with Tuberculoid Leprosy

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Search GEO for disease gene expression data for Tuberculoid Leprosy.

Pathways for genes affiliated with Tuberculoid Leprosy

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Pathways related to Tuberculoid Leprosy according to GeneCards Suite gene sharing:

(show all 48)
idSuper pathwaysScoreTop Affiliating Genes
19.8IFNG, TGFB1
29.8IFNG, IL10
39.8IFNG, IL10
4
Show member pathways
9.7TGFB1, TGFB2
5
Show member pathways
9.5TGFB1, TGFB3
69.5TGFB1, TGFB3
7
Show member pathways
9.5IFNG, IL10, TGFB1
89.5IFNG, IL10, TGFB1
99.5IFNG, IL10, TGFB1
109.4IFNG, TGFB1, TGFB2
119.3HSPA1A, IFNG, IL10
129.2BMP6, TGFB1, TGFB2
139.1TGFB1, TGFB2, TGFB3
14
Show member pathways
9.1TGFB1, TGFB2, TGFB3
159.1TGFB1, TGFB2, TGFB3
169.1TGFB1, TGFB2, TGFB3
17
Show member pathways
9.1TGFB1, TGFB2, TGFB3
18
Show member pathways
9.1TGFB1, TGFB2, TGFB3
199.1TGFB1, TGFB2, TGFB3
209.1TGFB1, TGFB2, TGFB3
219.1TGFB1, TGFB2, TGFB3
22
Show member pathways
9.1TGFB1, TGFB2, TGFB3
239.1TGFB1, TGFB2, TGFB3
249.0BMP6, IL10, TGFB3
258.8IFNG, TGFB1, TGFB2, TGFB3
26
Show member pathways
8.8IFNG, TGFB1, TGFB2, TGFB3
278.8IFNG, TGFB1, TGFB2, TGFB3
28
Show member pathways
8.7IL10, TGFB1, TGFB2, TGFB3
298.7IL10, TGFB1, TGFB2, TGFB3
308.6HSPA1A, TGFB1, TGFB2, TGFB3
318.6HSPA1A, TGFB1, TGFB2, TGFB3
328.6BMP6, TGFB1, TGFB2, TGFB3
338.6BMP6, TGFB1, TGFB2, TGFB3
348.6BMP6, TGFB1, TGFB2, TGFB3
358.6BMP6, TGFB1, TGFB2, TGFB3
368.6BMP6, TGFB1, TGFB2, TGFB3
37
Show member pathways
8.6BMP6, TGFB1, TGFB2, TGFB3
38
Show member pathways
8.4IFNG, IL10, TGFB1, TGFB2, TGFB3
39
Show member pathways
8.4IFNG, IL10, TGFB1, TGFB2, TGFB3
408.4IFNG, IL10, TGFB1, TGFB2, TGFB3
418.4IFNG, IL10, TGFB1, TGFB2, TGFB3
42
Show member pathways
8.2BMP6, IL10, TGFB1, TGFB2, TGFB3
438.1CORO1A, IFNG, IL10, TGFB1, TGFB2, TGFB3
44
Show member pathways
8.0HSPA1A, IFNG, IL10, TGFB1, TGFB2, TGFB3
45
Show member pathways
8.0HSPA1A, IFNG, IL10, TGFB1, TGFB2, TGFB3
46
Show member pathways
7.9BMP6, IFNG, IL10, TGFB1, TGFB2, TGFB3
47
Show member pathways
7.9BMP6, IFNG, IL10, TGFB1, TGFB2, TGFB3
48
Show member pathways
7.4BMP6, HSPA1A, IFNG, IL10, TGFB1, TGFB2

GO Terms for genes affiliated with Tuberculoid Leprosy

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Cellular components related to Tuberculoid Leprosy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:00310939.6TGFB1, TGFB2, TGFB3
2extracellular spaceGO:00056157.9BMP6, IFNG, IL10, TGFB1, TGFB2, TGFB3

Biological processes related to Tuberculoid Leprosy according to GeneCards Suite gene sharing:

(show all 50)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of interleukin-17 productionGO:003270010.5IFNG, TGFB1
2protein import into nucleus, translocationGO:000006010.5IFNG, TGFB1
3positive regulation of MHC class II biosynthetic processGO:004534810.4IFNG, IL10
4T cell homeostasisGO:004302910.4CORO1A, TGFB1
5defense response to protozoanGO:004283210.4IFNG, IL10
6regulation of complement-dependent cytotoxicityGO:190365910.4IL10, TGFB2
7pathway-restricted SMAD protein phosphorylationGO:006038910.4TGFB1, TGFB2
8positive regulation of protein localization to nucleusGO:190018210.4TGFB1, TGFB2
9negative regulation of growth of symbiont in hostGO:004413010.3IFNG, IL10
10negative regulation of immune responseGO:005077710.3TGFB1, TGFB2
11leukocyte chemotaxisGO:003059510.2CORO1A, IL10
12frontal suture morphogenesisGO:006036410.2TGFB1, TGFB3
13response to laminar fluid shear stressGO:003461610.2TGFB1, TGFB3
14regulation of epithelial to mesenchymal transition involved in endocardial cushion formationGO:190500510.2TGFB1, TGFB3
15uterine wall breakdownGO:004270410.2TGFB2, TGFB3
16negative regulation of DNA replicationGO:000815610.2TGFB1, TGFB3
17eye developmentGO:000165410.1BMP6, TGFB2
18positive regulation of collagen biosynthetic processGO:003296710.1TGFB1, TGFB3
19ossification involved in bone remodelingGO:004393210.1TGFB1, TGFB3
20odontogenesisGO:004247610.0TGFB2, TGFB3
21extrinsic apoptotic signaling pathwayGO:009719110.0IFNG, TGFB1, TGFB2
22mammary gland developmentGO:003087910.0TGFB1, TGFB3
23cell cycle arrestGO:00070509.9IFNG, TGFB1, TGFB2
24negative regulation of gene expressionGO:00106299.8IFNG, TGFB1, TGFB2
25SMAD protein import into nucleusGO:00071849.8TGFB1, TGFB2, TGFB3
26salivary gland morphogenesisGO:00074359.8TGFB1, TGFB2, TGFB3
27cell migrationGO:00164779.8CORO1A, TGFB1, TGFB2
28response to progesteroneGO:00325709.7TGFB1, TGFB2, TGFB3
29positive regulation of cell divisionGO:00517819.7TGFB1, TGFB2, TGFB3
30transforming growth factor beta receptor signaling pathwayGO:00071799.7TGFB1, TGFB2, TGFB3
31negative regulation of macrophage cytokine productionGO:00109369.7TGFB1, TGFB2, TGFB3
32platelet degranulationGO:00025769.7TGFB1, TGFB2, TGFB3
33cell-cell junction organizationGO:00452169.7TGFB1, TGFB2, TGFB3
34positive regulation of bone mineralizationGO:00305019.7BMP6, TGFB1, TGFB3
35positive regulation of epithelial to mesenchymal transitionGO:00107189.6TGFB1, TGFB2, TGFB3
36cell growthGO:00160499.6TGFB1, TGFB2, TGFB3
37face morphogenesisGO:00603259.5TGFB1, TGFB2, TGFB3
38positive regulation of SMAD protein import into nucleusGO:00603919.5BMP6, TGFB1, TGFB3
39agingGO:00075689.4IL10, TGFB1, TGFB3
40wound healingGO:00420609.4TGFB1, TGFB2, TGFB3
41positive regulation of transcription, DNA-templatedGO:00458939.2IFNG, IL10, TGFB1, TGFB3
42SMAD protein signal transductionGO:00603959.2BMP6, TGFB1, TGFB2, TGFB3
43positive regulation of gene expressionGO:00106289.1HSPA1A, IFNG, TGFB1, TGFB2
44positive regulation of pathway-restricted SMAD protein phosphorylationGO:00108629.1BMP6, TGFB1, TGFB2, TGFB3
45response to hypoxiaGO:00016669.0TGFB1, TGFB2, TGFB3
46positive regulation of protein secretionGO:00507149.0BMP6, TGFB1, TGFB2, TGFB3
47regulation of apoptotic processGO:00429818.9BMP6, TGFB1, TGFB2, TGFB3
48negative regulation of cell proliferationGO:00082858.9IFNG, TGFB1, TGFB2, TGFB3
49response to drugGO:00424938.7IFNG, IL10, TGFB1, TGFB2
50positive regulation of transcription from RNA polymerase II promoterGO:00459448.3BMP6, IFNG, IL10, TGFB1, TGFB3

Molecular functions related to Tuberculoid Leprosy according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1type I transforming growth factor beta receptor bindingGO:003471310.1TGFB1, TGFB3
2transforming growth factor beta receptor bindingGO:00051609.7BMP6, TGFB1, TGFB2
3type III transforming growth factor beta receptor bindingGO:00347149.7TGFB1, TGFB2, TGFB3
4type II transforming growth factor beta receptor bindingGO:00051149.7TGFB1, TGFB2, TGFB3
5protein heterodimerization activityGO:00469828.6BMP6, TGFB1, TGFB2, TGFB3
6growth factor activityGO:00080838.4BMP6, IL10, TGFB1, TGFB2, TGFB3
7cytokine activityGO:00051258.2BMP6, IFNG, IL10, TGFB1, TGFB2, TGFB3

Sources for Tuberculoid Leprosy

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet