MCID: TBR006
MIFTS: 43

Tuberculoid Leprosy malady

Infectious diseases category

Aliases & Classifications for Tuberculoid Leprosy

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Sources:
10Disease Ontology, 65UMLS, 47Novoseek, 36MeSH, 29ICD9CM, 59SNOMED-CT, 27ICD10
See all sources

Aliases & Descriptions for Tuberculoid Leprosy:

Name: Tuberculoid Leprosy 10 65
Leprosy, Tuberculoid 36
Leprosy Tuberculoid 47
 
Type T Leprosy 10
Smooth Leprosy 10


Classifications:



External Ids:

Disease Ontology10 DOID:1025
MeSH36 D015441
SNOMED-CT59 70143003
ICD9CM29 030.1
ICD1027 A30.1

Summaries for Tuberculoid Leprosy

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Disease Ontology:10 A leprosy that results in one erythematous large plaque with well-defined borders that are elevated and that slope down into an atrophic center.

MalaCards based summary: Tuberculoid Leprosy, also known as leprosy, tuberculoid, is related to leprosy and tuberculosis. An important gene associated with Tuberculoid Leprosy is IFNG (Interferon, Gamma), and among its related pathways are OX40 Pathway and ALK1 signaling events. Affiliated tissues include skin, bone and t cells, and related mouse phenotypes are craniofacial and respiratory system.

Wikipedia:68 Tuberculoid leprosy is a skin condition characterized by solitary skin lesions that are asymmetrically... more...

Related Diseases for Tuberculoid Leprosy

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Diseases related to Tuberculoid Leprosy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 181)
idRelated DiseaseScoreTop Affiliating Genes
1leprosy31.9CD40LG, IFNG, IL10
2tuberculosis31.0IFNG, IL10, TGFB1
3alopecia areata30.3CD4, IFNG, IL10
4melkersson-rosenthal syndrome30.2CD4, CD40LG
5colitis29.8CD4, CD40LG, IFNG, IL10
6leishmaniasis10.5
7pulmonary tuberculosis10.5
8lepromatous leprosy10.5
9neuritis10.5
10systemic lupus erythematosus10.4
11epidermodysplasia verruciformis10.4
12lupus erythematosus10.4
13hansen's disease10.4
14chronic ulcer of skin10.2TGFB1, TGFB3
15premature chromatid separation trait10.2TGFB2, TGFB3
16keratoconus10.2TGFB1, TGFB3
17clear cell adenocarcinoma10.2TGFB2, TGFB3
18basal ganglia cerebrovascular disease10.2IFNG, TGFB1
19uterine inversion10.2IFNG, TGFB1
20alopecia10.2
21cutaneous leishmaniasis10.2
22hepatitis10.2
23mycosis fungoides10.2
24ulcerative colitis10.2
25chromoblastomycosis10.2
26hepatitis c10.2
27mucocutaneous leishmaniasis10.2
28paracoccidioidomycosis10.2
29latent syphilis10.2
30molluscum contagiosum10.2
31allergic contact dermatitis10.2
32amyloidosis10.2
33cervicitis10.2
34contact dermatitis10.2
35dermatitis10.2
36histoplasmosis10.2
37neuropathy10.2
38retinitis10.2
39syphilis10.2
40neurologic diseases10.2
41cytomegalovirus retinitis10.2
42cd3epsilon deficiency10.2CD4, CORO1A
43idiopathic cd4-positive t-lymphocytopenia10.2IL10, TGFB1
44vulva adenocarcinoma10.2TGFB1, TGFB2
45branchiootorenal syndrome10.2IFNG, TGFB1
46potter's syndrome10.2IL10, TGFB1
47sensorineural hearing loss10.2IFNG, IL10
48graft-versus-host disease, protection against10.2IFNG, IL10
49buruli ulcer10.1IFNG, IL10
50chronic hiccups10.1IFNG, IL10

Graphical network of the top 20 diseases related to Tuberculoid Leprosy:



Diseases related to tuberculoid leprosy

Symptoms for Tuberculoid Leprosy

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Drugs & Therapeutics for Tuberculoid Leprosy

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Tuberculoid Leprosy


Cochrane evidence based reviews: Leprosy, Tuberculoid

Genetic Tests for Tuberculoid Leprosy

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Anatomical Context for Tuberculoid Leprosy

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MalaCards organs/tissues related to Tuberculoid Leprosy:

33
Skin, Bone, T cells, Testes, Liver, Lymph node, Bone marrow

Animal Models for Tuberculoid Leprosy or affiliated genes

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MGI Mouse Phenotypes related to Tuberculoid Leprosy:

38 (show all 15)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053829.0IFNG, IL10, TGFB1, TGFB2, TGFB3
2MP:00053888.7IFNG, IL10, TGFB1, TGFB2, TGFB3
3MP:00053678.5CD40LG, CORO1A, IFNG, TGFB1, TGFB2
4MP:00053818.4CD4, IFNG, IL10, TGFB1, TGFB2, TGFB3
5MP:00053808.2IFNG, IL10, SDHD, TGFB1, TGFB2, TGFB3
6MP:00053787.6CD4, HSPA1A, IFNG, IL10, SDHD, TGFB1
7MP:00053797.5CD40LG, IFNG, IL10, SDHD, TGFB1, TGFB2
8MP:00053897.4CD40LG, HSPA1A, IFNG, IL10, TGFB1, TGFB2
9MP:00053877.3CD4, CD40LG, CORO1A, IFNG, IL10, TGFB1
10MP:00053977.2CD4, CD40LG, CORO1A, IFNG, IL10, TGFB1
11MP:00053856.9CD40LG, HSPA1A, IFNG, IL10, SDHD, TGFB1
12MP:00107686.8CD4, CD40LG, IFNG, IL10, SDHD, TGFB1
13MP:00036316.2CD4, CD40LG, HSPA1A, IFNG, IL10, SDHD
14MP:00053766.2CD4, CD40LG, HSPA1A, IFNG, IL10, SDHD
15MP:00053846.1CD4, CD40LG, CORO1A, HSPA1A, IFNG, IL10

Publications for Tuberculoid Leprosy

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Articles related to Tuberculoid Leprosy:

(show top 50)    (show all 234)
idTitleAuthorsYear
1
Borderline tuberculoid leprosy with scrofuloderma: an uncommon association. (25035384)
2014
2
Borderline tuberculoid leprosy and type 1 leprosy reaction in a hepatitis C patient during treatment with interferon and ribavirin. (24346894)
2013
3
Borderline tuberculoid leprosy mimicking mycosis fungoides. (24517048)
2013
4
Images in clinical medicine. Tuberculoid leprosy. (21524216)
2011
5
Post-traumatic inoculation tuberculoid leprosy after injury with a glass bangle. (19743627)
2009
6
Borderline tuberculoid leprosy--an unusual presentation: a case report. (19295116)
2008
7
Immune reconstitution inflammatory syndrome or upgrading type 1 reaction? Report of two AIDS patients presenting a shifting from borderline lepromatous leprosy to borderline tuberculoid leprosy. (19274990)
2008
8
Greater auricular nerve abscess in borderline tuberculoid leprosy masquerading as jugular vein thrombosis. (17091546)
2006
9
Borderline tuberculoid leprosy in a woman from the state of Georgia with armadillo exposure. (17010758)
2006
10
Borderline tuberculoid leprosy with type 1 reaction in an HIV patient--a phenomenon of immune reconstitution. (16830642)
2005
11
Tuberculoid leprosy confined to glans penis in two cases. (15282972)
2004
12
A case of post-partum borderline tuberculoid leprosy complicated by a median nerve abscess, peptic ulceration and rifampicin-induced haemolytic renal failure. (15282971)
2004
13
Expression of cyclooxygenase type 2 in lepromatous and tuberculoid leprosy lesions. (12752141)
2003
14
Variants of HLA-DR2/DR51 group haplotypes and susceptibility to tuberculoid leprosy and pulmonary tuberculosis in Asian Indians. (7602219)
1995
15
An evaluation of the S-100 stain in the histological diagnosis of tuberculoid leprosy and other granulomatous dermatoses. (8046265)
1994
16
Borderline tuberculoid leprosy developing in a pure neuritic case. (1783794)
1991
17
Tuberculoid leprosy--an unusual presentation. (2086689)
1990
18
A case of tuberculoid leprosy in Rhode Island. (2293316)
1990
19
Suppression of delayed hypersensitivity skin reactions to tuberculin by M. leprae antigens in patients with lepromatous and tuberculoid leprosy. (3308210)
1987
20
Tuberculoid leprosy in Mexicans is associated with HLA-DR3. (3501513)
1987
21
Mycobacterium leprae-reactive T-cell clones isolated from polar lepromatous and tuberculoid leprosy patients. (2830893)
1987
22
Six cases of dapsone-resistant tuberculoid leprosy. (6399070)
1984
23
Clinical electrophysiologic assessment of ulnar nerve transposition in tuberculoid leprosy. (6642835)
1983
24
In vitro lymphocyte stimulation in an approach to study the expression of HLA-encoded genes predisposing to tuberculoid leprosy. (6408015)
1983
25
Regional lymph node involvement in tuberculoid leprosy. (6668925)
1983
26
The pathogenesis and classification of polar tuberculoid leprosy]. (7078339)
1982
27
Pure neural tuberculoid leprosy simulating a peripheral nerve tumor. (7110557)
1982
28
Serum enzyme profile in tuberculoid leprosy. (7098444)
1982
29
Tuberculoid leprosy and HLA in Japanese. (6953616)
1981
30
Borderline tuberculoid leprosy following BCG vaccination. A case report. (7195879)
1981
31
Borderline tuberculoid leprosy with a 'lepromatous' nodule of the nasal mucosa: a case report. (6991811)
1980
32
Some aspects of tuberculoid leprosy and chemotherapeutic trials. (116471)
1979
33
Tuberculoid leprosy and tuberculosis skin: a comparative histopathological study. (895075)
1977
34
Tuberculoid leprosy: a neurologic case report. (4504012)
1972
35
Trial of high dosages of dapsone in the treatment of tuberculoid leprosy. (5150030)
1971
36
Phenoloxidase activity in organisms isolated from lepromatous and tuberculoid leprosy. (16559125)
1970
37
The Kveim test in lepromatous and tuberculoid leprosy. (5394258)
1969
38
Borderline tuberculoid leprosy with neuralgia. (5350424)
1969
39
Tuberculoid leprosy. (5981448)
1966
40
Pure neural tuberculoid leprosy. (4283894)
1965
41
A NEW TECHNIQUE FOR DETECTING MYCOBACTERIUM LEPRAE AND THE PROBLEM OF INFECTIOUSNESS OF TUBERCULOID LEPROSY. (14333144)
1965
42
THE ROLE OF PYRAZON IN REACTIONS IN TUBERCULOID LEPROSY. (14282489)
1964
43
Tuberculoid leprosy in identical twins. (13515394)
1958
44
Primary and secondary tuberculoid leprosy. (13405586)
1956
45
The sulfone treatment of tuberculoid leprosy. (14803132)
1950
46
Transformation of a case of tuberculoid leprosy in reaction to the lepromatous form. (15421705)
1950
47
Tuberculoid leprosy; warty lepride. (18873454)
1948
48
Tuberculoid leprosy. (21065780)
1946
49
Tuberculoid leprosy. (21013478)
1946
50
Demonstration of South African Tuberculoid Leprosy. (19988735)
1932

Variations for Tuberculoid Leprosy

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Expression for genes affiliated with Tuberculoid Leprosy

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Search GEO for disease gene expression data for Tuberculoid Leprosy.

Pathways for genes affiliated with Tuberculoid Leprosy

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Pathways related to Tuberculoid Leprosy according to GeneCards Suite gene sharing:

(show all 45)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8IFNG, IL10
2
Show member pathways
9.7TGFB1, TGFB3
39.7TGFB1, TGFB3
49.4CD40LG, IFNG
59.3HSPA1A, IFNG, IL10
69.3IFNG, TGFB1, TGFB2
79.3CD4, IFNG, TGFB1
89.2TGFB1, TGFB2, TGFB3
9
Show member pathways
9.2TGFB1, TGFB2, TGFB3
10
Show member pathways
9.2TGFB1, TGFB2, TGFB3
119.2TGFB1, TGFB2, TGFB3
129.2TGFB1, TGFB2, TGFB3
139.2TGFB1, TGFB2, TGFB3
149.2TGFB1, TGFB2, TGFB3
15
TGF-beta Signaling Pathway (sino)
Show member pathways
9.2TGFB1, TGFB2, TGFB3
16
Show member pathways
9.2TGFB1, TGFB2, TGFB3
179.2TGFB1, TGFB2, TGFB3
18
Show member pathways
9.2TGFB1, TGFB2, TGFB3
199.2TGFB1, TGFB2, TGFB3
20
Angiogenesis (CST)
Show member pathways
9.2TGFB1, TGFB2, TGFB3
219.2TGFB1, TGFB2, TGFB3
228.9CD4, IFNG, IL10, TGFB1
23
Show member pathways
8.9CD4, IFNG, IL10, TGFB1
248.9IFNG, TGFB1, TGFB2, TGFB3
258.9IFNG, TGFB1, TGFB2, TGFB3
26
TGF-beta signaling pathway (KEGG)
Show member pathways
8.9IFNG, TGFB1, TGFB2, TGFB3
278.8IL10, TGFB1, TGFB2, TGFB3
28
Show member pathways
8.8IL10, TGFB1, TGFB2, TGFB3
298.7HSPA1A, TGFB1, TGFB2, TGFB3
308.7HSPA1A, TGFB1, TGFB2, TGFB3
31
Show member pathways
8.5IFNG, IL10, TGFB1, TGFB2, TGFB3
328.5IFNG, IL10, TGFB1, TGFB2, TGFB3
33
Show member pathways
8.5IFNG, IL10, TGFB1, TGFB2, TGFB3
348.5CD4, CD40LG, IFNG, IL10
35
Show member pathways
8.4CD40LG, TGFB1, TGFB2, TGFB3
36
Show member pathways
8.4CD4, IFNG, TGFB1, TGFB2, TGFB3
378.2CORO1A, IFNG, IL10, TGFB1, TGFB2, TGFB3
38
B cell receptor signaling pathway (KEGG)
Show member pathways
8.1CORO1A, IFNG, IL10, TGFB1, TGFB2, TGFB3
39
Show member pathways
8.0CD4, IFNG, IL10, TGFB1, TGFB2, TGFB3
407.7CD40LG, IFNG, IL10, TGFB1, TGFB2, TGFB3
41
Show member pathways
7.5CD4, CD40LG, IL10, TGFB1, TGFB2, TGFB3
42
Show member pathways
7.5CD4, CD40LG, IL10, TGFB1, TGFB2, TGFB3
43
Show member pathways
7.2CD40LG, HSPA1A, IFNG, IL10, TGFB1, TGFB2
44
Show member pathways
6.7CD4, CD40LG, HSPA1A, IFNG, IL10, TGFB1
45
Show member pathways
6.7CD4, CD40LG, HSPA1A, IFNG, IL10, TGFB1

GO Terms for genes affiliated with Tuberculoid Leprosy

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Cellular components related to Tuberculoid Leprosy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:00310939.7TGFB1, TGFB2, TGFB3
2extracellular spaceGO:00056157.7CD40LG, IFNG, IL10, TGFB1, TGFB2, TGFB3

Biological processes related to Tuberculoid Leprosy according to GeneCards Suite gene sharing:

(show all 50)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of interleukin-17 productionGO:003270010.5IFNG, TGFB1
2protein import into nucleus, translocationGO:000006010.5IFNG, TGFB1
3positive regulation of MHC class II biosynthetic processGO:004534810.4IFNG, IL10
4frontal suture morphogenesisGO:006036410.4TGFB1, TGFB3
5response to laminar fluid shear stressGO:003461610.4TGFB1, TGFB3
6positive regulation of collagen biosynthetic processGO:003296710.4TGFB1, TGFB3
7positive regulation of SMAD protein import into nucleusGO:006039110.4TGFB1, TGFB3
8defense response to protozoanGO:004283210.3IFNG, IL10
9T cell homeostasisGO:004302910.3CORO1A, TGFB1
10mammary gland developmentGO:003087910.3TGFB1, TGFB3
11leukocyte chemotaxisGO:003059510.3CORO1A, IL10
12negative regulation of growth of symbiont in hostGO:004413010.3IFNG, IL10
13negative regulation of DNA replicationGO:000815610.3TGFB1, TGFB3
14positive regulation of bone mineralizationGO:003050110.3TGFB1, TGFB3
15positive regulation of epithelial cell migrationGO:001063410.2IFNG, TGFB2
16regulation of complement-dependent cytotoxicityGO:190365910.2IL10, TGFB2
17pathway-restricted SMAD protein phosphorylationGO:006038910.2TGFB1, TGFB2
18ossification involved in bone remodelingGO:004393210.2TGFB1, TGFB3
19uterine wall breakdownGO:004270410.2TGFB2, TGFB3
20positive regulation of T cell activationGO:005087010.1CD4, CORO1A
21odontogenesisGO:004247610.1TGFB2, TGFB3
22extrinsic apoptotic signaling pathwayGO:00971919.9IFNG, TGFB1, TGFB2
23positive regulation of interleukin-12 productionGO:00327359.9CD40LG, IFNG
24SMAD protein import into nucleusGO:00071849.9TGFB1, TGFB2, TGFB3
25negative regulation of macrophage cytokine productionGO:00109369.9TGFB1, TGFB2, TGFB3
26positive regulation of protein secretionGO:00507149.8TGFB1, TGFB2, TGFB3
27positive regulation of epithelial to mesenchymal transitionGO:00107189.8TGFB1, TGFB2, TGFB3
28salivary gland morphogenesisGO:00074359.8TGFB1, TGFB2, TGFB3
29growthGO:00400079.8TGFB1, TGFB2, TGFB3
30positive regulation of pathway-restricted SMAD protein phosphorylationGO:00108629.8TGFB1, TGFB2, TGFB3
31negative regulation of immune responseGO:00507779.8TGFB1, TGFB2
32B cell proliferationGO:00421009.8CD40LG, IL10
33response to progesteroneGO:00325709.8TGFB1, TGFB2, TGFB3
34platelet degranulationGO:00025769.7TGFB1, TGFB2, TGFB3
35SMAD protein signal transductionGO:00603959.7TGFB1, TGFB2, TGFB3
36cell cycle arrestGO:00070509.7IFNG, TGFB1, TGFB2
37face morphogenesisGO:00603259.7TGFB1, TGFB2, TGFB3
38cell-cell junction organizationGO:00452169.7TGFB1, TGFB2, TGFB3
39cell developmentGO:00484689.6TGFB1, TGFB2, TGFB3
40agingGO:00075689.6IL10, TGFB1, TGFB3
41response to hypoxiaGO:00016669.5TGFB1, TGFB2, TGFB3
42transforming growth factor beta receptor signaling pathwayGO:00071799.5TGFB1, TGFB2, TGFB3
43wound healingGO:00420609.4TGFB1, TGFB2, TGFB3
44positive regulation of transcription, DNA-templatedGO:00458939.4IFNG, IL10, TGFB1, TGFB3
45cell growthGO:00160499.3TGFB1, TGFB2, TGFB3
46negative regulation of cell proliferationGO:00082859.3IFNG, TGFB1, TGFB2, TGFB3
47response to drugGO:00424939.2IFNG, IL10, TGFB1, TGFB2
48positive regulation of gene expressionGO:00106289.1HSPA1A, IFNG, TGFB1, TGFB2
49immune responseGO:00069558.8CD4, CD40LG, IFNG, IL10
50platelet activationGO:00301688.4CD40LG, TGFB1, TGFB2, TGFB3

Molecular functions related to Tuberculoid Leprosy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1type I transforming growth factor beta receptor bindingGO:003471310.2TGFB1, TGFB3
2type III transforming growth factor beta receptor bindingGO:00347149.6TGFB1, TGFB2, TGFB3
3type II transforming growth factor beta receptor bindingGO:00051149.6TGFB1, TGFB2, TGFB3
4growth factor activityGO:00080838.8IL10, TGFB1, TGFB2, TGFB3
5cytokine activityGO:00051257.7CD40LG, IFNG, IL10, TGFB1, TGFB2, TGFB3

Sources for Tuberculoid Leprosy

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet