MCID: TBR006
MIFTS: 44

Tuberculoid Leprosy malady

Category: Infectious diseases

Aliases & Classifications for Tuberculoid Leprosy

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Aliases & Descriptions for Tuberculoid Leprosy:

Name: Tuberculoid Leprosy 11 13 66
Leprosy, Tuberculoid 37
Leprosy Tuberculoid 48
 
Smooth Leprosy 11
Type T Leprosy 11

Classifications:



External Ids:

Disease Ontology11 DOID:1025
ICD1028 A30.1
SNOMED-CT60 70143003
ICD9CM30 030.1
MeSH37 D015441

Summaries for Tuberculoid Leprosy

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Disease Ontology:11 A leprosy that results in one erythematous large plaque with well-defined borders that are elevated and that slope down into an atrophic center.

MalaCards based summary: Tuberculoid Leprosy, also known as leprosy, tuberculoid, is related to leprosy and hypohidrosis. An important gene associated with Tuberculoid Leprosy is CORO1A (Coronin 1A), and among its related pathways are IL-2 Gene Expression in Activated and Quiescent T-Cells and Glypican 1 network. Affiliated tissues include skin, t cells and testes, and related mouse phenotypes are digestive/alimentary and endocrine/exocrine gland.

Wikipedia:69 Tuberculoid leprosy is a skin condition characterized by solitary skin lesions that are asymmetrically... more...

Related Diseases for Tuberculoid Leprosy

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Diseases related to Tuberculoid Leprosy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 148)
idRelated DiseaseScoreTop Affiliating Genes
1leprosy11.5
2hypohidrosis10.6BMP6, TGFB1
3diamond-blackfan anemia10.6TGFB1, TGFB2
4acromicric dysplasia10.5TGFB1, TGFB2
5fibrosclerosis of breast10.5TGFB1, TGFB2
6tgfbr1-related loeys-dietz syndrome10.5TGFB2, TGFB3
7loeys-dietz syndrome 410.5TGFB2, TGFB3
8naegeli-franceschetti-jadassohn syndrome/dermatopathia pigmentosa reticularis10.5BMP6, TGFB1
9peanut allergy10.5TGFB1, TGFB2
10renal clear cell carcinoma10.4TGFB2, TGFB3
11adenosine monophosphate deaminase deficiency erythrocyte type10.4TGFB2, TGFB3
12vitreous abscess10.4TGFB1, TGFB2
13addison's disease10.4IL2, TGFB1
14leukemia10.4TGFB1, TGFB2
15ornithosis10.4CD40LG, CORO1A
16calcifying epithelial odontogenic tumor10.4IL2, TGFB1
17actinomycosis10.3BMP6, TGFB1
18renal hypertension10.3CD40LG, TGFB1
19urinary schistosomiasis10.3CD40LG, TGFB1
20tuberculosis10.3
21loin pain hematuria syndrome10.2CD40LG, TGFB1
22holoprosencephaly10.2BMP6, TGFB1, TGFB2
23leishmaniasis10.2
24cd40 ligand deficiency10.2CD4, CORO1A
25brown's tendon sheath syndrome10.2CD40LG, SDHD
26brucella abortus brucellosis10.2CD40LG, IL2
27twin-to-twin transfusion syndrome10.2TGFB1, TGFB2, TGFB3
28idiopathic corneal edema10.2TGFB1, TGFB2, TGFB3
2946 xy gonadal dysgenesis10.2TGFB1, TGFB2, TGFB3
30lung abscess10.2CD40LG, SDHD
31epidemic typhus10.1TGFB1, TGFB2, TGFB3
32lepromatous leprosy10.1
33neuritis10.1
34pulmonary tuberculosis10.1
35japanese encephalitis10.1CD40LG, IL2
36ethmoid sinus adenoid cystic carcinoma10.1BMP6, CD4
37ovarian endometrioid malignant adenofibroma10.1CD40LG, IL2
38systemic lupus erythematosus10.0
39epidermodysplasia verruciformis10.0
40mycosis fungoides10.0
41lupus erythematosus10.0
42hansen's disease10.0
43familial mitral valve prolapse10.0BMP6, TGFB3
44rectal prolapse10.0CD4, IL2
45echinococcosis9.9CD4, TGFB1
46recurrent hypersomnia9.9CD4, CD40LG
47sapho syndrome9.9CD4, CD40LG
48diphyllobothriasis9.9CD4, CD40LG
49melkersson-rosenthal syndrome9.9
50alopecia9.9

Graphical network of the top 20 diseases related to Tuberculoid Leprosy:



Diseases related to tuberculoid leprosy

Symptoms for Tuberculoid Leprosy

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Drugs & Therapeutics for Tuberculoid Leprosy

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Tuberculoid Leprosy


Cochrane evidence based reviews: leprosy, tuberculoid

Genetic Tests for Tuberculoid Leprosy

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Anatomical Context for Tuberculoid Leprosy

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MalaCards organs/tissues related to Tuberculoid Leprosy:

34
Skin, T cells, Testes, Liver, Bone, Lymph node, Bone marrow

Animal Models for Tuberculoid Leprosy or affiliated genes

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MGI Mouse Phenotypes related to Tuberculoid Leprosy:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.2CD4, IL2, TGFB1, TGFB2, TGFB3
2MP:00053797.1CD4, CD40LG, CORO1A, IL2, SDHD, TGFB1
3MP:00053846.8CD4, CD40LG, CORO1A, IL2, SDHD, TGFB1

Publications for Tuberculoid Leprosy

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Articles related to Tuberculoid Leprosy:

(show top 50)    (show all 237)
idTitleAuthorsYear
1
Borderline tuberculoid leprosy with scrofuloderma: an uncommon association. (25035384)
2014
2
Sporotrichoid pattern of nerve abscesses in borderline tuberculoid leprosy: A Case Report (sporotrichoid like abscesses in leprosy). (26411249)
2014
3
Borderline tuberculoid leprosy and type 1 leprosy reaction in a hepatitis C patient during treatment with interferon and ribavirin. (24346894)
2013
4
Borderline tuberculoid leprosy mimicking mycosis fungoides. (24517048)
2013
5
Clinical presentation of tuberculoid leprosy in an epidermodysplasia verruciformis patient. (22711134)
2012
6
Post-traumatic inoculation tuberculoid leprosy after injury with a glass bangle. (19743627)
2009
7
Borderline tuberculoid leprosy--an unusual presentation: a case report. (19295116)
2008
8
Immune reconstitution inflammatory syndrome or upgrading type 1 reaction? Report of two AIDS patients presenting a shifting from borderline lepromatous leprosy to borderline tuberculoid leprosy. (19274990)
2008
9
Greater auricular nerve abscess in borderline tuberculoid leprosy masquerading as jugular vein thrombosis. (17091546)
2006
10
Borderline tuberculoid leprosy in a woman from the state of Georgia with armadillo exposure. (17010758)
2006
11
Borderline tuberculoid leprosy with type 1 reaction in an HIV patient--a phenomenon of immune reconstitution. (16830642)
2005
12
Borderline tuberculoid leprosy localised over a scar. (16044818)
2005
13
Tuberculoid leprosy confined to glans penis in two cases. (15282972)
2004
14
A case of post-partum borderline tuberculoid leprosy complicated by a median nerve abscess, peptic ulceration and rifampicin-induced haemolytic renal failure. (15282971)
2004
15
Cutaneous granulomas masquerading as tuberculoid leprosy in a patient with congenital combined immunodeficiency. (11514920)
2001
16
Pathologic changes in a tibial nerve with surviving M. leprae in a healed tuberculoid leprosy patient. (9207758)
1997
17
Electro neuro physiological studies in early tuberculoid leprosy. (8345232)
1993
18
Tuberculoid leprosy--an unusual presentation. (2086689)
1990
19
Mycobacterium leprae-specific T cells from a tuberculoid leprosy patient suppress HLA-DR3-restricted T cell responses to an immunodominant epitope on 65-kDa hsp of mycobacteria. (1701000)
1990
20
Psoralene in repigmentation of tuberculoid leprosy. (2625362)
1989
21
Destruction of ala nasi and loss of columella in borderline tuberculoid leprosy--a case report. (2703741)
1989
22
Calcification of ulnar nerve in a patient with tuberculoid leprosy--a case report. (2539417)
1989
23
A follow up study of borderline tuberculoid leprosy under sulphone monotherapy. (3204273)
1988
24
Photoactivated topical 8-methoxypsoralen in repigmentation of a tuberculoid leprosy lesion. (3373082)
1988
25
Tuberculoid leprosy in Mexicans is associated with HLA-DR3. (3501513)
1987
26
Subpolar tuberculoid leprosy. (3440846)
1987
27
Melkersson-Rosenthal syndrome masquerading as tuberculoid leprosy. (3611858)
1987
28
Six cases of dapsone-resistant tuberculoid leprosy. (6399070)
1984
29
Clinical electrophysiologic assessment of ulnar nerve transposition in tuberculoid leprosy. (6642835)
1983
30
In vitro lymphocyte stimulation in an approach to study the expression of HLA-encoded genes predisposing to tuberculoid leprosy. (6408015)
1983
31
The pathogenesis and classification of polar tuberculoid leprosy]. (7078339)
1982
32
Serum enzyme profile in tuberculoid leprosy. (7098444)
1982
33
Nerve damage in tuberculoid leprosy. (7132297)
1982
34
Tuberculoid leprosy and HLA in Japanese. (6953616)
1981
35
Borderline tuberculoid leprosy following BCG vaccination. A case report. (7195879)
1981
36
Variation of in vitro lymphocyte responses to M. leprae antigen in borderline tuberculoid leprosy patients. (6154019)
1980
37
Some aspects of tuberculoid leprosy and chemotherapeutic trials. (116471)
1979
38
Mycobacterium leprae in the striated muscle of tuberculoid leprosy patients. (359926)
1978
39
Tuberculoid leprosy: a neurologic case report. (4504012)
1972
40
Trial of high dosages of dapsone in the treatment of tuberculoid leprosy. (5150030)
1971
41
Phenoloxidase activity in organisms isolated from lepromatous and tuberculoid leprosy. (16559125)
1970
42
Fate of Mycobacterium leprae in macrophages of patients with lepromatous or tuberculoid leprosy. (4929374)
1970
43
Solitary neural tuberculoid leprosy. (4298827)
1968
44
Pure neural tuberculoid leprosy. (4283894)
1965
45
THE ROLE OF PYRAZON IN REACTIONS IN TUBERCULOID LEPROSY. (14282489)
1964
46
Tuberculoid leprosy in identical twins. (13515394)
1958
47
Primary and secondary tuberculoid leprosy. (13405586)
1956
48
Tuberculoid leprosy. (13091392)
1953
49
Tuberculoid leprosy of lupoid appearance. (20292635)
1947
50
Tuberculoid leprosy. (21065780)
1946

Variations for Tuberculoid Leprosy

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Expression for genes affiliated with Tuberculoid Leprosy

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Search GEO for disease gene expression data for Tuberculoid Leprosy.

Pathways for genes affiliated with Tuberculoid Leprosy

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Pathways related to Tuberculoid Leprosy according to GeneCards Suite gene sharing:

(show top 50)    (show all 56)
idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.7TGFB1, TGFB2
29.7TGFB1, TGFB3
39.4BMP6, TGFB1, TGFB2
49.3TGFB1, TGFB2, TGFB3
59.3TGFB1, TGFB2, TGFB3
6
Show member pathways
9.3TGFB1, TGFB2, TGFB3
7
Show member pathways
9.3TGFB1, TGFB2, TGFB3
89.3TGFB1, TGFB2, TGFB3
9
Show member pathways
9.3TGFB1, TGFB2, TGFB3
109.3TGFB1, TGFB2, TGFB3
119.3TGFB1, TGFB2, TGFB3
12
Show member pathways
9.3TGFB1, TGFB2, TGFB3
13
Show member pathways
9.3TGFB1, TGFB2, TGFB3
149.3TGFB1, TGFB2, TGFB3
159.3TGFB1, TGFB2, TGFB3
169.3TGFB1, TGFB2, TGFB3
179.3TGFB1, TGFB2, TGFB3
189.3TGFB1, TGFB2, TGFB3
199.0CORO1A, TGFB1, TGFB2, TGFB3
208.9HSPA1A, TGFB1, TGFB2, TGFB3
218.9HSPA1A, TGFB1, TGFB2, TGFB3
22
Show member pathways
8.9BMP6, TGFB1, TGFB2, TGFB3
238.9BMP6, TGFB1, TGFB2, TGFB3
248.9BMP6, TGFB1, TGFB2, TGFB3
258.9BMP6, TGFB1, TGFB2, TGFB3
268.9BMP6, TGFB1, TGFB2, TGFB3
278.8CD4, IL2, TGFB1
288.8CD4, IL2, TGFB1
29
Show member pathways
8.8CD4, IL2, TGFB1
308.8CD4, IL2, TGFB1
318.8IL2, TGFB1, TGFB2, TGFB3
32
Show member pathways
8.8IL2, TGFB1, TGFB2, TGFB3
338.7CD40LG, TGFB1, TGFB2, TGFB3
348.7CD40LG, TGFB1, TGFB2, TGFB3
358.5BMP6, CD40LG, IL2, TGFB3
36
Show member pathways
8.5CD4, TGFB1, TGFB2, TGFB3
37
Show member pathways
8.4BMP6, IL2, TGFB1, TGFB2, TGFB3
38
Show member pathways
8.4BMP6, IL2, TGFB1, TGFB2, TGFB3
39
Show member pathways
8.4BMP6, IL2, TGFB1, TGFB2, TGFB3
408.4BMP6, IL2, TGFB1, TGFB2, TGFB3
41
Show member pathways
8.3CD40LG, HSPA1A, TGFB1, TGFB2, TGFB3
42
Show member pathways
8.2CD4, CD40LG, IL2, TGFB1
43
Show member pathways
7.8BMP6, CD40LG, IL2, TGFB1, TGFB2, TGFB3
44
Show member pathways
7.6BMP6, CD4, IL2, TGFB1, TGFB2, TGFB3
45
Show member pathways
7.6BMP6, CD4, IL2, TGFB1, TGFB2, TGFB3
46
Show member pathways
7.0CD4, CD40LG, HSPA1A, IL2, TGFB1, TGFB2
47
Show member pathways
6.9BMP6, CD4, CD40LG, IL2, TGFB1, TGFB2
48
Show member pathways
6.9BMP6, CD4, CD40LG, IL2, TGFB1, TGFB2
49
Show member pathways
6.9BMP6, CD4, CD40LG, IL2, TGFB1, TGFB2
50
Show member pathways
6.6BMP6, CD4, CD40LG, HSPA1A, IL2, TGFB1

GO Terms for genes affiliated with Tuberculoid Leprosy

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Cellular components related to Tuberculoid Leprosy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:00310939.9TGFB1, TGFB2, TGFB3
2cell surfaceGO:00099868.0CD4, CD40LG, TGFB1, TGFB3
3extracellular spaceGO:00056157.8BMP6, CD40LG, IL2, TGFB1, TGFB2, TGFB3

Biological processes related to Tuberculoid Leprosy according to GeneCards Suite gene sharing:

(show all 42)
idNameGO IDScoreTop Affiliating Genes
1T cell homeostasisGO:004302910.4CORO1A, TGFB1
2pathway-restricted SMAD protein phosphorylationGO:006038910.4TGFB1, TGFB2
3frontal suture morphogenesisGO:006036410.4TGFB1, TGFB3
4response to laminar fluid shear stressGO:003461610.4TGFB1, TGFB3
5regulation of epithelial to mesenchymal transition involved in endocardial cushion formationGO:190500510.4TGFB1, TGFB3
6positive regulation of interleukin-17 productionGO:003274010.3IL2, TGFB1
7positive regulation of protein localization to nucleusGO:190018210.3TGFB1, TGFB2
8uterine wall breakdownGO:004270410.3TGFB2, TGFB3
9negative regulation of DNA replicationGO:000815610.3TGFB1, TGFB3
10negative regulation of immune responseGO:005077710.2TGFB1, TGFB2
11mammary gland developmentGO:003087910.2TGFB1, TGFB3
12eye developmentGO:000165410.2BMP6, TGFB2
13positive regulation of regulatory T cell differentiationGO:004559110.2IL2, TGFB1
14epithelial to mesenchymal transitionGO:000183710.2TGFB1, TGFB2
15positive regulation of collagen biosynthetic processGO:003296710.1TGFB1, TGFB3
16ossification involved in bone remodelingGO:004393210.1TGFB1, TGFB3
17odontogenesisGO:004247610.1TGFB2, TGFB3
18SMAD protein import into nucleusGO:00071849.9TGFB1, TGFB2, TGFB3
19positive regulation of bone mineralizationGO:00305019.9BMP6, TGFB1, TGFB3
20salivary gland morphogenesisGO:00074359.9TGFB1, TGFB2, TGFB3
21positive regulation of T cell activationGO:00508709.9CD4, CORO1A
22positive regulation of cell divisionGO:00517819.8TGFB1, TGFB2, TGFB3
23transforming growth factor beta receptor signaling pathwayGO:00071799.8TGFB1, TGFB2, TGFB3
24negative regulation of macrophage cytokine productionGO:00109369.8TGFB1, TGFB2, TGFB3
25cell-cell junction organizationGO:00452169.7TGFB1, TGFB2, TGFB3
26platelet degranulationGO:00025769.7TGFB1, TGFB2, TGFB3
27positive regulation of SMAD protein import into nucleusGO:00603919.7BMP6, TGFB1, TGFB3
28positive regulation of epithelial to mesenchymal transitionGO:00107189.7TGFB1, TGFB2, TGFB3
29cell growthGO:00160499.6TGFB1, TGFB2, TGFB3
30response to vitamin DGO:00332809.6CD4, TGFB1
31positive regulation of NF-kappaB transcription factor activityGO:00510929.5CD40LG, HSPA1A, TGFB1
32face morphogenesisGO:00603259.5TGFB1, TGFB2, TGFB3
33SMAD protein signal transductionGO:00603959.4BMP6, TGFB1, TGFB2, TGFB3
34cell migrationGO:00164779.3CORO1A, TGFB1, TGFB2
35positive regulation of pathway-restricted SMAD protein phosphorylationGO:00108629.3BMP6, TGFB1, TGFB2, TGFB3
36response to progesteroneGO:00325709.3TGFB1, TGFB2, TGFB3
37wound healingGO:00420609.3TGFB1, TGFB2, TGFB3
38regulation of apoptotic processGO:00429819.2BMP6, TGFB1, TGFB2, TGFB3
39positive regulation of protein secretionGO:00507149.1BMP6, TGFB1, TGFB2, TGFB3
40T cell differentiationGO:00302179.0CD4, IL2, TGFB1
41response to hypoxiaGO:00016669.0TGFB1, TGFB2, TGFB3
42positive regulation of T cell proliferationGO:00421028.4CD4, CD40LG, CORO1A, IL2

Molecular functions related to Tuberculoid Leprosy according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1type I transforming growth factor beta receptor bindingGO:003471310.3TGFB1, TGFB3
2type III transforming growth factor beta receptor bindingGO:00347149.9TGFB1, TGFB2, TGFB3
3transforming growth factor beta receptor bindingGO:00051609.9BMP6, TGFB1, TGFB2
4type II transforming growth factor beta receptor bindingGO:00051149.8TGFB1, TGFB2, TGFB3
5protein heterodimerization activityGO:00469828.9BMP6, TGFB1, TGFB2, TGFB3
6growth factor activityGO:00080838.6BMP6, IL2, TGFB1, TGFB2, TGFB3
7cytokine activityGO:00051258.0BMP6, CD40LG, IL2, TGFB1, TGFB2, TGFB3

Sources for Tuberculoid Leprosy

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet