MCID: TBR006
MIFTS: 39

Tuberculoid Leprosy malady

Infectious diseases category
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Summaries for Tuberculoid Leprosy

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Sources:
8Disease Ontology, 65Wikipedia, 33MalaCards
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Disease Ontology:8 A leprosy that results in one erythematous large plaque with well-defined borders that are elevated and that slope down into an atrophic center.

MalaCards: Tuberculoid Leprosy, also known as leprosy tuberculoid, is related to leprosy and tuberculosis. An important gene associated with Tuberculoid Leprosy is HSPA1A (heat shock 70kDa protein 1A), and among its related pathways are MAPK signaling pathway and Influenza A. The compounds 8-isoprostane and alpha lipoic acid have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and testes.

Wikipedia:65 Tuberculoid leprosy is a skin condition characterized by solitary skin lesions that are asymmetrically... more...

Aliases & Classifications for Tuberculoid Leprosy

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8Disease Ontology, 62UMLS, 45Novoseek, 58SNOMED-CT, 35MeSH, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Aliases & Descriptions:

tuberculoid leprosy 8 62
leprosy tuberculoid 45
smooth leprosy 8
type t leprosy 8


External Ids:

Disease Ontology8 DOID:1025
MeSH35 D015441
SNOMED-CT58 70143003
ICD9CM27 030.1
ICD1025 A30.1

Related Diseases for Tuberculoid Leprosy

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Tuberculoid Leprosy:



Diseases related to tuberculoid leprosy

Symptoms for Tuberculoid Leprosy

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Drugs & Therapeutics for Tuberculoid Leprosy

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Tuberculoid Leprosy

Search NIH Clinical Center for Tuberculoid Leprosy

Genetic Tests for Tuberculoid Leprosy

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Anatomical Context for Tuberculoid Leprosy

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33MalaCards
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MalaCards organs/tissues related to Tuberculoid Leprosy:

33
Skin, T cells, Testes, Liver, Bone, Lymph node, Bone marrow

Animal Models for Tuberculoid Leprosy or affiliated genes

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Publications for Tuberculoid Leprosy

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52PubMed
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Articles related to Tuberculoid Leprosy:

(show top 50)    (show all 221)
idTitleAuthorsYear
1
Borderline tuberculoid leprosy and type 1 leprosy reaction in a hepatitis C patient during treatment with interferon and ribavirin. (24346894)
2013
2
Images in clinical medicine. Tuberculoid leprosy. (21524216)
2011
3
Post-traumatic inoculation tuberculoid leprosy after injury with a glass bangle. (19743627)
2009
4
Borderline tuberculoid leprosy--an unusual presentation: a case report. (19295116)
2008
5
Immune reconstitution inflammatory syndrome or upgrading type 1 reaction? Report of two AIDS patients presenting a shifting from borderline lepromatous leprosy to borderline tuberculoid leprosy. (19274990)
2008
6
Greater auricular nerve abscess in borderline tuberculoid leprosy masquerading as jugular vein thrombosis. (17091546)
2006
7
Borderline tuberculoid leprosy in a woman from the state of Georgia with armadillo exposure. (17010758)
2006
8
Borderline tuberculoid leprosy with type 1 reaction in an HIV patient--a phenomenon of immune reconstitution. (16830642)
2005
9
Tuberculoid leprosy confined to glans penis in two cases. (15282972)
2004
10
A case of post-partum borderline tuberculoid leprosy complicated by a median nerve abscess, peptic ulceration and rifampicin-induced haemolytic renal failure. (15282971)
2004
11
Expression of cyclooxygenase type 2 in lepromatous and tuberculoid leprosy lesions. (12752141)
2003
12
Variants of HLA-DR2/DR51 group haplotypes and susceptibility to tuberculoid leprosy and pulmonary tuberculosis in Asian Indians. (7602219)
1995
13
An evaluation of the S-100 stain in the histological diagnosis of tuberculoid leprosy and other granulomatous dermatoses. (8046265)
1994
14
Borderline tuberculoid leprosy developing in a pure neuritic case. (1783794)
1991
15
Tuberculoid leprosy--an unusual presentation. (2086689)
1990
16
A case of tuberculoid leprosy in Rhode Island. (2293316)
1990
17
Mycobacterium leprae-specific T cells from a tuberculoid leprosy patient suppress HLA-DR3-restricted T cell responses to an immunodominant epitope on 65-kDa hsp of mycobacteria. (1701000)
1990
18
Psoralene in repigmentation of tuberculoid leprosy. (2625362)
1989
19
Suppression of delayed hypersensitivity skin reactions to tuberculin by M. leprae antigens in patients with lepromatous and tuberculoid leprosy. (3308210)
1987
20
Tuberculoid leprosy in Mexicans is associated with HLA-DR3. (3501513)
1987
21
Mycobacterium leprae-reactive T-cell clones isolated from polar lepromatous and tuberculoid leprosy patients. (2830893)
1987
22
Six cases of dapsone-resistant tuberculoid leprosy. (6399070)
1984
23
Clinical electrophysiologic assessment of ulnar nerve transposition in tuberculoid leprosy. (6642835)
1983
24
In vitro lymphocyte stimulation in an approach to study the expression of HLA-encoded genes predisposing to tuberculoid leprosy. (6408015)
1983
25
Regional lymph node involvement in tuberculoid leprosy. (6668925)
1983
26
The pathogenesis and classification of polar tuberculoid leprosy]. (7078339)
1982
27
Pure neural tuberculoid leprosy simulating a peripheral nerve tumor. (7110557)
1982
28
Serum enzyme profile in tuberculoid leprosy. (7098444)
1982
29
Tuberculoid leprosy and HLA in Japanese. (6953616)
1981
30
Borderline tuberculoid leprosy following BCG vaccination. A case report. (7195879)
1981
31
Borderline tuberculoid leprosy with a 'lepromatous' nodule of the nasal mucosa: a case report. (6991811)
1980
32
Some aspects of tuberculoid leprosy and chemotherapeutic trials. (116471)
1979
33
Tuberculoid leprosy and tuberculosis skin: a comparative histopathological study. (895075)
1977
34
Tuberculoid leprosy: a neurologic case report. (4504012)
1972
35
Trial of high dosages of dapsone in the treatment of tuberculoid leprosy. (5150030)
1971
36
Phenoloxidase activity in organisms isolated from lepromatous and tuberculoid leprosy. (16559125)
1970
37
The Kveim test in lepromatous and tuberculoid leprosy. (5394258)
1969
38
Borderline tuberculoid leprosy with neuralgia. (5350424)
1969
39
Tuberculoid leprosy. (5981448)
1966
40
Pure neural tuberculoid leprosy. (4283894)
1965
41
A NEW TECHNIQUE FOR DETECTING MYCOBACTERIUM LEPRAE AND THE PROBLEM OF INFECTIOUSNESS OF TUBERCULOID LEPROSY. (14333144)
1965
42
THE ROLE OF PYRAZON IN REACTIONS IN TUBERCULOID LEPROSY. (14282489)
1964
43
Tuberculoid leprosy in identical twins. (13515394)
1958
44
Primary and secondary tuberculoid leprosy. (13405586)
1956
45
The sulfone treatment of tuberculoid leprosy. (14803132)
1950
46
Transformation of a case of tuberculoid leprosy in reaction to the lepromatous form. (15421705)
1950
47
Tuberculoid leprosy; warty lepride. (18873454)
1948
48
Tuberculoid leprosy. (21065780)
1946
49
Tuberculoid leprosy. (21013478)
1946
50
Demonstration of South African Tuberculoid Leprosy. (19988735)
1932

Variations for Tuberculoid Leprosy

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Expression for genes affiliated with Tuberculoid Leprosy

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Tuberculoid Leprosy

Search GEO for disease gene expression data for Tuberculoid Leprosy.

Pathways for genes affiliated with Tuberculoid Leprosy

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Sources:
50PathCards, 30KEGG, 38NCBI BioSystems Database, 53QIAGEN, 57SinoBiological, 54R&D Systems, 60Thomson Reuters, 55Reactome
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Pathways related to Tuberculoid Leprosy according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
MAPK signaling pathway38
9.1TNF, HSPA1A
2
Show member pathways
9.1HSPA1A, TNF
3
Show member pathways
9.1TNF, HSPA1A
4
Show member pathways
9.1TNF, HSPA1A
5
Show member pathways
9.1TNF, HSPA1A
69.1HSPA1A, TNF
7
Show member pathways
9.1TNF, HSPA1A
8
Show member pathways
Apoptosis and survival TNFR1 signaling pathway60
TWEAK Signaling Pathway38
Apoptosis Modulation by HSP7038
HIV-1 Nef- Negative effector of Fas and TNF-alpha38
9.1TNF, HSPA1A
9
Show member pathways
9.1HSPA1A, TNF

Compounds for genes affiliated with Tuberculoid Leprosy

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45Novoseek, 51PharmGKB, 11DrugBank, 61Tocris Bioscience, 29IUPHAR, 24HMDB
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Compounds related to Tuberculoid Leprosy according to GeneCards/GeneDecks:

(show all 21)
idCompoundScoreTop Affiliating Genes
18-isoprostane459.5HSPA1A, TNF
2alpha lipoic acid459.5TNF, HSPA1A
3carbamazepine45 51 1111.5TNF, HSPA1A
4manganese superoxide459.5HSPA1A, TNF
515-deoxy-delta-12,14-prostaglandin j2459.4TNF, HSPA1A
6mg 13245 6110.4TNF, HSPA1A
7endotoxin459.4HSPA1A, TNF
8fmlp459.4TNF, HSPA1A
9n acetylcysteine459.4HSPA1A, TNF
10sb 20358045 6110.4HSPA1A, TNF
11pd 98,059459.4HSPA1A, TNF
12actinomycin d459.4TNF, HSPA1A
13cyclosporin a45 29 6111.3HSPA1A, TNF
14lactate459.3TNF, HSPA1A
15superoxide45 2410.3TNF, HSPA1A
16cycloheximide459.2TNF, HSPA1A
17h2o2459.2HSPA1A, TNF
18dexamethasone45 51 29 1112.1HSPA1A, TNF
19lipid459.1HSPA1A, TNF
20nitric oxide45 24 1111.0TNF, HSPA1A
21oxygen45 249.8TNF, HSPA1A

GO Terms for genes affiliated with Tuberculoid Leprosy

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Products for genes affiliated with Tuberculoid Leprosy

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Tuberculoid Leprosy

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet