TB
MCID: TBR010
MIFTS: 84

Tuberculosis (TB) malady

Infectious diseases category

Summaries for Tuberculosis

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 33MedlinePlus, 3CDC, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 Tuberculosis (tb) is a disease caused by bacteria called mycobacterium tuberculosis. the bacteria usually attack the lungs, but they can also damage other parts of the body. tb spreads through the air when a person with tb of the lungs or throat coughs, sneezes, or talks. if you have been exposed, you should go to your doctor for tests. you are more likely to get tb if you have a weak immune system. symptoms of tb in the lungs may include a bad cough that lasts 3 weeks or longer weight loss loss of appetite coughing up blood or mucus weakness or fatigue fever night sweats skin tests, blood tests, x-rays, and other tests can tell if you have tb. if not treated properly, tb can be deadly. you can usually cure active tb by taking several medicines for a long period of time. nih: national institute of allergy and infectious diseases

MalaCards: Tuberculosis, also known as tuberculous abscess, is related to pulmonary tuberculosis and extrapulmonary tuberculosis. An important gene associated with Tuberculosis is IFNGR1 (interferon gamma receptor 1), and among its related pathways are Allograft rejection and Immune System. The drugs antitubercular agents and ethambutol and the compounds ionomycin and sb 203580 have been mentioned in the context of this disorder. Affiliated tissues include lungs, lymph nodes and pleura or, and related mouse phenotypes are immune system and hematopoietic system.

Disease Ontology:8 A primary bacterial infectious disease that is located in lungs, located in lymph nodes, located in pericardium, located in brain, located in pleura or located in gastrointestinal tract, has material basis in mycobacterium tuberculosis, which is transmitted by droplets released into the air when an infected person coughs or sneezes.

NIH Rare Diseases:42 Tuberculosis (tb) is a contagious and often severe airborne disease caused by infection with mycobacterium tuberculosis (mtb). tb typically affects the lungs, but it also can affect any other organ of the body. it is estimated that more than one-third of the world’s population has mtb infection; however, only one in ten people infected with tb bacteria develop active tb disease. early symptoms of active tb can include weight loss, fever, night sweats, and loss of appetite. symptoms involving areas other than the lungs vary, depending upon the organ or area affected. it is usually treated with a regimen of drugs taken for 6 months to 2 years depending on the type of infection, and can be cured in most people. last updated: 5/13/2011

CDC:3 TB is a disease caused by a bacterium called Mycobacterium tuberculosis. The bacteria usually attack the lungs, but TB bacteria can attack any part of the body such as the kidney, spine, and brain. If not treated properly, TB disease can be fatal. TB disease was once the leading cause of death in the United States. Learn More »

Wikipedia:63 Tuberculosis, MTB, or TB (short for tubercle bacillus), in the past also called phthisis, phthisis... more...

Description from OMIM:46 607948

Aliases & Classifications for Tuberculosis

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 46OMIM, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 9diseasecard, 38NCBI Bookshelf, 34MeSH, 56SNOMED-CT, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Aliases & Descriptions:

tuberculosis 8 42 46 10 44 33 60
tuberculous abscess 8 60
tuberculoma 8 60
tb 42 38
tuberculosis, susceptibility to 9
kochs disease 42


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Disease Ontology8 DOID:399
MeSH34 D014375
SNOMED-CT56 15202009

Related Diseases for Tuberculosis

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Tuberculosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 697)
idRelated DiseaseScoreTop Affiliating Genes
1pulmonary tuberculosis31.9IL18, IL10, INHA, VDR, MBL2, IFNGR1
2extrapulmonary tuberculosis31.4ADA
3pleural tuberculosis31.2ADA, IL18, IFNG
4hepatitis31.1TLR2, IL18
5meningitis30.9ADA, MBL2, TLR2
6crohn's disease30.9TNF, IRGM
7peritonitis30.8TLR2, TNF, ADA
8arthritis30.8TLR2, IFNG, TNF, CISH, VDR, IL10
9sarcoidosis30.8SLC11A1, P2RX7, IL12RB1, IL18, TNF, IFNGR1
10rheumatoid arthritis30.7TLR2, IFNG, MBL2, TNF, CISH, IL10
11pneumonia30.7TLR2, MBL2, TNF, IL10
12leprosy30.6SLC11A1, TLR2
13pleurisy30.5ADA
14pancreatitis30.5IL10
15diabetes mellitus30.5TNF, VDR
16pulmonary sarcoidosis30.4IFNG, TNF, IL18, IL12RB1
17lupus erythematosus30.4IL18
18systemic lupus erythematosus30.4TLR2, IFNG, IFNGR1, MBL2, TNF, IL10
19vasculitis30.4TNF, MBL2
20aspergillosis30.3TLR2, IFNG, MBL2
21leukemia30.3TLR2, IFNG, MBL2, TNF, CISH, VDR
22glomerulonephritis30.3MBL2
23brucellosis30.3SLC11A1
24uveitis30.3IFNG, TNF, CISH, IL10, IL4
25osteomyelitis30.2IFNGR1
26inflammatory bowel disease30.2TLR2, IFNG, TNF, VDR, IL10, IL18
27psoriasis30.2TLR2, IFNG, TNF, VDR, IL10, IL18
28lepromatous leprosy30.2IL4, IL10, IFNG, TLR2
29viral hepatitis30.1CISH, TLR2
30adenocarcinoma30.1ADA, INHA
31otitis media30.1TLR2, MBL2
32bronchiectasis30.1MBL2, TLR2
33sarcoma30.1ADA, VDR
34paracoccidioidomycosis30.1IL10
35thyroiditis30.1MBL2
36allergic bronchopulmonary aspergillosis30.1MBL2, IL4
37melioidosis30.1TLR2
38asthma30.1SLC11A1, IL4, IL12RB1, IL18, IL10, VDR
39tuberculoid leprosy30.1IL10, IFNG
40ankylosing spondylitis30.1TNF
41hepatitis c30.1TLR2, IFNG, TNF, CISH, IL10, IL18
42malaria30.0TLR2, IFNG, IFNGR1, TNF, IL10, SLC11A1
43lymphopenia30.0IFNG, IL10, IL18, IL4, ADA
44prostatitis30.0VDR
45leishmaniasis30.0SLC11A1, IL4, IL10, IFNGR1, IFNG
46hepatitis b30.0TLR2, IFNG, MBL2, IL10, IL18
47eosinophilia30.0IFNG, MBL2, IL10, IL18, IL4
48breast cancer30.0IFNGR1, CISH, VDR, INHA, ADA
49synovitis30.0TLR2, TNF, IL18
50mycobacterium avium complex disease30.0IFNGR1

Graphical network of the top 20 diseases related to Tuberculosis:



Diseases related to tuberculosis

Clinical Features for Tuberculosis

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Sources:
46OMIM
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Clinical features from OMIM:

607948

Drugs & Therapeutics for Tuberculosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Tuberculosis

Drug clinical trials:

Search ClinicalTrials for Tuberculosis

Search NIH Clinical Center for Tuberculosis

Search CenterWatch for Tuberculosis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Tuberculosis

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Anatomical Context for Tuberculosis

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Sources:
32MalaCards, 14FMA
See all sources

MalaCards organs/tissues related to Tuberculosis:

32
Lung, Testes, T cells, Lymph node, Monocytes, Skin, Brain, Kidney, Liver, Bone, Whole blood, Bone marrow, Heart, Colon, Breast, Spleen, Thyroid, B cells, Prostate, Tongue, Pituitary, Eye, Tonsil, Nk cells, Small intestine, Adrenal gland, Pancreas, Ovary, Myeloid, Testis, Uterus, Cervix, Appendix, Cortex, Adrenal cortex, Thymus, Retina, Pons, Spinal cord, Smooth muscle

FMA organs/tissues related to Tuberculosis:

14
Lungs, Lymph nodes, Pleura or, Brain, Pericardium

Animal Models for Tuberculosis or affiliated genes

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36MGI
See all sources

MGI Mouse Phenotypes related to Tuberculosis:

36 (show all 15)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538713.9ADA, TLR2, IFNG, IFNGR1, MBL2, TNF
2MP:000539713.7VDR, TNF, MBL2, IFNGR1, IFNG, TLR2
3MP:000537613.4TLR2, IFNG, IFNGR1, MBL2, TNF, IRGM
4MP:000538112.8TLR2, IFNG, IFNGR1, TNF, VDR, INHA
5MP:001076812.8VDR, TNF, IFNGR1, IFNG, INHA, IL10
6MP:000538412.6TLR2, IFNG, IFNGR1, TNF, VDR, IL10
7MP:000538512.5TLR2, IFNG, IFNGR1, TNF, VDR, INHA
8MP:000537012.4TLR2, IFNG, IFNGR1, TNF, INHA, IL10
9MP:000537812.3TLR2, IFNG, TNF, VDR, INHA, IL10
10MP:000200611.9IFNG, IFNGR1, TNF, INHA, IL10, SLC11A1
11MP:000537911.9TLR2, IFNG, TNF, VDR, INHA, IL4
12MP:000539011.4IFNGR1, INHA, IL4
13MP:001077111.2P2RX7, VDR, TLR2
14MP:000538911.0IFNGR1, VDR, INHA
15MP:000536711.0TLR2, IFNGR1

Publications for Tuberculosis

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Sources:
50PubMed
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Articles related to Tuberculosis:

(show top 50)    (show all 6947)
idTitleAuthorsYear
1
Improved survival in multidrug-resistant tuberculosis patients receiving integrated tuberculosis and antiretroviral treatment in the SAPiT Trial. (24429305)
2014
2
An update on the use of rifapentine for tuberculosis therapy. (24397259)
2014
3
Solution structure of Rv0569, potent hypoxic signal transduction protein, from Mycobacterium tuberculosis. (24275361)
2014
4
Pulmonary hemorrhage complicating Goodpasture's disease in the course of pulmonary tuberculosis. (22826144)
2013
5
$ 1.4 billion funding shortfall for tuberculosis control. (24400359)
2013
6
Cost-effectiveness of routine diagnostic evaluation of pulmonary tuberculosis in a primary care unit in Brazil. (24025387)
2013
7
Idiopathic infantile hypercalcemia or an extrapulmonary complication of tuberculosis? (23581265)
2013
8
Tuberculosis Incidence in HIV/AIDS Patients in Israel, 1983-2010. (24278157)
2013
9
Interferon I^ in patients with HIV/AIDS and suspicion or latent tuberculosis infection. (23339916)
2013
10
Farm-level risk factors for the occurrence, new infection or persistence of tuberculosis in cattle herds from South-Central Spain. (24299905)
2013
11
Meta-analysis to compare the accuracy of GeneXpert, MODS and the WHO 2007 algorithm for diagnosis of smear-negative pulmonary tuberculosis. (24172543)
2013
12
Generation of Mycobacterium tuberculosis-specific recombinant antigens and evaluation of the clinical value of antibodyA detection for serological diagnosis of pulmonary tuberculosis. (23338746)
2013
13
Comparison of direct versus concentrated smear microscopy in detection of pulmonary tuberculosis. (23885922)
2013
14
Splenic tuberculosis presenting as ascites in immunocompetant patient. (23634345)
2013
15
Altered microRNA expression levels in mononuclear cells of patients with pulmonary and pleural tuberculosis and their relation with components of the immune response. (22964481)
2013
16
Bronchoscopic evaluation in childhood pulmonary tuberculosis: risk factors of airway involvement and contribution to the bacteriologic diagnosis. (23470678)
2013
17
Bronchoscopy for the diagnosis of pulmonary tuberculosis in patients with negative sputum smear microscopy results. (22576423)
2012
18
An unusual presentation of pulmonary cryptococcosis with co-existing disseminated tuberculosis in an AIDS patient. (22290112)
2012
19
Moxifloxacin in multidrug-resistant tuberculosis: is there any indication for therapeutic drug monitoring? (23024328)
2012
20
Tuberculosis of knee joint and tubercular pyomyositis of gastrocnemius muscle. (22081197)
2011
21
Analysis of genetic predisposition to pulmonary tuberculosis in native Russians]. (20297661)
2010
22
Genetic polymorphism of glutathione-S-transferase M1 and T1: a systematic review in Chinese population and a pilot study in smear-positive pulmonary tuberculosis cases of Jilin province]. (19799150)
2009
23
Prevalence and risk factors for multidrug-resistant tuberculosis in the Republic of Georgia: a population-based study. (19105881)
2009
24
Blocking TNF in vitro with infliximab determines the inhibition of expansion and interferon gamma production of Vgamma9/Vdelta2 T lymphocytes from patients with active rheumatoid arthritis. A role in the susceptibility to tuberculosis? (19370184)
2009
25
Interferon-gamma release assay on suspicion of active tuberculosis?]. (19758505)
2009
26
Tuberculosis and silicosis: epidemiology, diagnosis and chemoprophylaxis. (19099104)
2008
27
Invariant NKT cells from HIV-1 or Mycobacterium tuberculosis-infected patients express an activated phenotype. (18304877)
2008
28
Emergence of levofloxacin-non-susceptible Streptococcus pneumoniae and treatment for multidrug-resistant tuberculosis in children in South Africa: a cohort observational surveillance study. (18359074)
2008
29
Comparison of interferon-gamma release assay versus tuberculin skin test for tuberculosis screening in inflammatory bowel disease. (18684188)
2008
30
The immuno-endocrine component in the pathogenesis of tuberculosis. (17635794)
2007
31
Polymerase chain reaction for detection of Mycobacterium tuberculosis in papanicolaou-stained fine needle aspirated smears for diagnosis of cervical tuberculous lymphadenitis. (17333737)
2006
32
Linezolid for the treatment of multidrug-resistant tuberculosis. (15911549)
2005
33
Effect of deletion or overexpression of the 19-kilodalton lipoprotein Rv3763 on the innate response to Mycobacterium tuberculosis. (16177361)
2005
34
Skeletal tuberculosis in children. (15278319)
2004
35
Interferon-gamma receptor-1 gene polymorphism in tuberculosis patients from Croatia. (12753505)
2003
36
Differential regulation of MMP-1/9 and TIMP-1 secretion in human monocytic cells in response to Mycobacterium tuberculosis. (11827797)
2002
37
Genetic basis of tuberculosis susceptibility in India. (12501922)
2002
38
Colorectal cancer and intestinal tuberculosis. (8129360)
1993
39
Differential cytokine gene expression and secretion after phagocytosis by a human monocytic cell line of Toxoplasma gondii compared with Mycobacterium tuberculosis. (8428393)
1993
40
Mycobacterium tuberculosis polymerase chain reaction findings in neurosarcoidosis. (8289073)
1993
41
Undernutrition in lepromatous leprosy. V. Severe nutritional deficit in lepromatous patients co-infected with pulmonary tuberculosis. (2707215)
1989
42
Liver in abdominal tuberculosis. (3759877)
1986
43
Extrapulmonary tuberculosis. Experience of a community hospital and review of the literature. (4050833)
1985
44
Lymph node tuberculosis: a comparison of treatments 18 months after completion of chemotherapy. (473381)
1979
45
Liver in abdominal tuberculosis. (5700154)
1968
46
Renal tuberculosis in the Japanese. (6023230)
1967
47
Cyanoacetylhydrazine in therapy of urogenital tuberculosis; test of use as sole medication]. (14395579)
1955
48
Renal tuberculosis; prognosis after nephrectomy. (13188559)
1954
49
A case of gall bladder tuberculosis. (18120767)
1949
50
Current views on renal tuberculosis. (18871087)
1948

Genetic Variations for Tuberculosis

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Expression for genes affiliated with Tuberculosis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Tuberculosis

Search GEO for disease gene expression data for Tuberculosis.

Pathways for genes affiliated with Tuberculosis

About this section
Sources:
29KEGG, 51QIAGEN, 53Reactome, 37NCBI BioSystems Database, 52R&D Systems, 12EMD Millipore, 4Cell Signaling Technology
See all sources

Pathways related to Tuberculosis according to GeneCards/GeneDecks:

(show all 37)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.9IFNG, IFNGR1, TNF, IL10, IL18, IL12RB1
2
Hide members
11.9TLR2, IFNG, IFNGR1, MBL2, CISH, IL18
3
Hide members
11.9TLR2, IFNG, IFNGR1, TNF, IL10, IL18
411.9TLR2, IFNG, IFNGR1, TNF, VDR, IL10
511.7IFNG, IFNGR1, CISH, IL10, IL12RB1, IL4
6
Hide members
11.7TLR2, IFNG, IFNGR1, TNF, IL18, IL4
7
Hide members
11.7IL4, IL12RB1, IL18, IL10, TNF, TLR2
8
Hide members
11.5IL12RB1, IL18, IRGM, IFNGR1, TLR2
9
Hide members
11.5TLR2, IFNG, IFNGR1, TNF, IL10
10
Hide members
11.5TLR2, IFNG, IFNGR1, TNF, IL4
1111.5IFNG, TNF, IL10, IL18, IL4
12
Development PDGF signaling via STATs and NF-kB
Hide members
11.5IFNG, TNF, IL10, IL18, IL12RB1
13
Hide members
11.3IFNG, IFNGR1, CISH, IL18
1411.3TLR2, IFNG, IFNGR1, TNF
15
Immune response Bacterial infections in normal airways
11.3TNF, IFNGR1, IFNG, TLR2
1611.3IFNG, TNF, IL10, IL18
17
Hide members
11.3IL4, IL12RB1, IL18, IFNG
1811.3IL10, TNF, IFNG, TLR2
1911.3TLR2, IFNG, TNF, IL18
20
Hide members
11.3TLR2, TNF, IL18, P2RX7
2111.1IL18, IFNGR1, IFNG
22
Development Thrombopoetin signaling via JAK-STAT pathway
Hide members
11.1IFNG, CISH, IL4
23
Hide members
11.1TNF, IFNGR1, IFNG
2411.1IFNG, IL10, IL4
25
Hide members
11.1IL10, TNF, IFNG
26
Hide members
11.1IL4, TNF, IFNG
2711.1IL18, TNF, TLR2
28
Transcription Role of VDR in regulation of genes involved in osteoporosis
Hide members
11.1IFNG, TNF, VDR
29
Hide members
11.1P2RX7, IL18, TNF
3010.9IFNGR1, IFNG
31
Hide members
10.9IFNGR1, IL12RB1
32
Hide members
10.9IL12RB1, CISH
33
Hide members
10.9IFNG, IL4
3410.9IL18, TLR2
3510.9IL18, TLR2
3610.9VDR, TNF
3710.7IL12RB1

Compounds for genes affiliated with Tuberculosis

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Sources:
44Novoseek, 59Tocris Bioscience, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 2BitterDB
See all sources

Compounds related to Tuberculosis according to GeneCards/GeneDecks:

(show top 50)    (show all 89)
idCompoundScoreTop Affiliating Genes
1ionomycin4412.6GNLY, IL4, IL18, IL12RB1, IL10, TNF
2sb 20358044 5913.6TNF, P2RX7, IFNG, IL4, IL18, IL10
3vegf4412.5ADA, IL4, MBL2, TLR2, IL10, IFNG
4nitric oxide44 11 2414.5IL10, MBL2, IL18, SLC11A1, CISH, IFNG
5polymyxin b4412.4IL10, P2RX7, IL4, TNF, MBL2, IFNG
6il 104412.4IFNG, TNF, TLR2, VDR, IL10, IL18
7neopterin4412.4IFNG, TNF, IL10, IL18, IL4, MBL2
8tacrolimus44 49 1114.4IL4, IL18, IL10, VDR, TNF, IFNG
9histamine44 28 2414.3IFNG, IL10, TLR2, TNF, IL18, IL4
10il-124412.2IL4, IL12RB1, IL10, IFNG, TNF, IL18
11polyinosinic-polycytidylic acid4412.2TLR2, IFNG, TNF, IL10, IL4, IL18
12ribavirin44 49 1114.2ADA, IL18, IL10, MBL2, IFNG, IL4
13simvastatin44 49 59 28 11 2417.1IL4, IL10, TNF, IFNG, TLR2, IL18
14calcitriol44 59 11 2415.1TLR2, IFNG, IL10, TNF, VDR, IL4
15tuberculin4412.0IFNG, MBL2, IL10, IL18, ADA
16rantes4412.0TNF, MBL2, IL4, TLR2, IFNG
17imiquimod44 28 59 1114.9IL18, TNF, IFNG, TLR2, IL10
18con a4411.9IL18, MBL2, IL4, IL10, IFNG
19lipoteichoic acid4411.9IL18, IL10, TNF, MBL2, TLR2
20poly(i-c)4411.9TLR2, IFNG, TNF, IL18, IL4
21infliximab44 49 1113.9IFNG, TNF, IL10, IL18, IL4
22tarc4411.9IL4, IL18, IL10, TNF, IFNG
23ccl344 2812.9IL18, TNF, IL10, IFNG, TLR2
24dexamethasone44 49 28 1114.8CISH, VDR, TLR2, ADA
25cyclosporin a44 28 5913.7IFNG, ADA, P2RX7, VDR
26interferon gamma4411.7IL4, IL10, TNF, IFNG
27natalizumab44 1112.7IFNG, TNF, IL10, IL18
28okt34411.7IFNG, TNF, IL10, IL4
29arginine4411.6TLR2, IL4, IL18, VDR, GNLY, ADA
302,5-oligoadenylate4411.6TNF, ADA, IFNG, IL10
31etanercept44 49 1113.6IL10, IL18, TNF, IFNG
32anti-fungal4411.6MBL2, GNLY, IFNG, TLR2
33peptidoglycan44 2812.5TLR2, MBL2, TNF, IL10
34ivig4411.5IL4, IFNG, TNF, IL10
35ifn-alpha4411.5IFNG, IL18, IL10, CISH
36gm-csf44 2812.5IFNG, IL10, TNF
3715-deoxy-delta-12,14-prostaglandin j24411.5IFNG, IL10, TNF, IL4
38allergens4411.5IL4, IL18, IL10, IFNG
39betaseron4411.4IFNG, IL10, IL4
40alpha-galactosylceramide4411.4IFNG, IL4, IL10
41chloroquine44 2 49 28 1115.3IL10, IL18, IL4, TNF
42pentoxifylline44 1112.3IL4, IL18
43mip 1alpha4411.2IL4, IL10, TNF
44thalidomide44 49 59 1114.2IL18, TNF, IL10, IFNG
45cycloheximide4411.2IL18, TLR2
46glatiramer acetate44 1112.2IFNG, IL10, IL4
47rolipram44 59 2813.1ADA
48amphotericin b4411.0ADA
49prednisolone44 28 1113.0MBL2
50pdtc4410.7IL18

GO Terms for genes affiliated with Tuberculosis

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Sources:
16Gene Ontology
See all sources

Cellular components related to Tuberculosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561511.8IFNG, GNLY, MBL2, TNF, IL10, IL18
2external side of plasma membraneGO:00989711.8ADA, TLR2, IFNG, TNF, IL12RB1, IL4
3phagocytic cupGO:00189110.9IRGM, TNF

Biological processes related to Tuberculosis according to GeneCards/GeneDecks:

(show all 33)
idNameGO IDScoreTop Affiliating Genes
1inflammatory responseGO:00695412.3TLR2, TNF, IRGM, IL10, IL18, P2RX7
2positive regulation of transcription from RNA polymerase II promoterGO:04594412.3TLR2, IFNG, TNF, VDR, IL10, IL4
3negative regulation of growth of symbiont in hostGO:04413011.9IL10, TNF, MBL2, IFNG, TLR2
4defense response to bacteriumGO:04274211.9IFNG, GNLY, MBL2, IL10, SLC11A1
5response to drugGO:04249311.8IFNG, TNF, IL10, IL4, P2RX7
6signal transductionGO:00716511.7TLR2, IFNGR1, VDR, INHA, IL12RB1, SP110
7positive regulation of interferon-gamma productionGO:03272911.7SLC11A1, IL12RB1, IL18, TNF
8defense response to Gram-positive bacteriumGO:05083011.7TLR2, MBL2, TNF, P2RX7
9type 2 immune responseGO:04209211.5IL10, IL18, IL4
10positive regulation of MHC class II biosynthetic processGO:04534811.5IL4, IL10, IFNG
11positive regulation of chemokine biosynthetic processGO:04508011.5IFNG, TNF, IL4
12defense response to protozoanGO:04283211.5IFNG, IL4, SLC11A1
13positive regulation of chemokine productionGO:03272211.5TLR2, TNF, IL18
14positive regulation of activated T cell proliferationGO:04210411.5IL18, IL12RB1, IL4
15positive regulation of NF-kappaB import into nucleusGO:04234611.4IL18, TNF, TLR2
16protein import into nucleus, translocationGO:00006011.4IFNG, TNF, SLC11A1
17positive regulation of cytokine secretionGO:05071511.4IL10, TNF, TLR2
18lipopolysaccharide-mediated signaling pathwayGO:03166311.4IL18, TNF, TLR2
19positive regulation of nitric oxide biosynthetic processGO:04542911.4TNF, IFNG, TLR2
20positive regulation of tumor necrosis factor productionGO:03276011.4TLR2, IFNG, IL18
21positive regulation of interleukin-6 productionGO:03275511.3TLR2, TNF, P2RX7
22positive regulation of vitamin D biosynthetic processGO:06055711.2IFNG, TNF
23positive regulation of sequence-specific DNA binding transcription factor activityGO:05109111.2IL4, IL10, TNF
24positive regulation of calcidiol 1-monooxygenase activityGO:06055911.2IFNG, TNF
25regulation of isotype switchingGO:04519111.1IL10, IL4
26receptor biosynthetic processGO:03280011.1TNF, IL10
27negative regulation of cytokine secretion involved in immune responseGO:00274011.1IL10, TNF
28positive regulation of isotype switching to IgG isotypesGO:04830411.1IL4, IFNG
29negative regulation of interleukin-17 productionGO:03270011.0IFNG, TLR2
30positive regulation of T-helper 1 type immune responseGO:00282711.0IL12RB1, SLC11A1
31positive regulation of membrane protein ectodomain proteolysisGO:05104410.9TNF, IFNG
32negative regulation of nitric oxide biosynthetic processGO:04501910.8IL4, IL10
33negative regulation of interleukin-12 productionGO:03269510.6IL10, TLR2

Molecular functions related to Tuberculosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00512511.7IL4, IL18, IL10, INHA, TNF, IFNG

Products for genes affiliated with Tuberculosis

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  • Antibodies
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Sources for Tuberculosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet