MCID: TBR010
MIFTS: 73

Tuberculosis malady

Rare diseases, Infectious diseases, Reproductive diseases, Respiratory diseases, Endocrine diseases, Cardiovascular diseases, Neuronal diseases categories

Summaries for Tuberculosis

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MedlinePlus:32 Tuberculosis (tb) is a disease caused by bacteria called mycobacterium tuberculosis. the bacteria usually attack the lungs, but they can also damage other parts of the body. tb spreads through the air when a person with tb of the lungs or throat coughs, sneezes, or talks. if you have been exposed, you should go to your doctor for tests. you are more likely to get tb if you have a weak immune system. symptoms of tb in the lungs may include a bad cough that lasts 3 weeks or longer weight loss loss of appetite coughing up blood or mucus weakness or fatigue fever night sweats skin tests, blood tests, x-rays, and other tests can tell if you have tb. if not treated properly, tb can be deadly. you can usually cure active tb by taking several medicines for a long period of time. nih: national institute of allergy and infectious diseases

MalaCards based summary: Tuberculosis, also known as tb, is related to pulmonary tuberculosis and extrapulmonary tuberculosis. An important gene associated with Tuberculosis is CCL2 (chemokine (C-C motif) ligand 2), and among its related pathways are LDL Oxidation in Atherogenesis and Hypertrophy Model. The drugs antitubercular agents and ethambutol and the compounds interferon gamma and tuberculin have been mentioned in the context of this disorder. Affiliated tissues include lungs, lymph nodes and pericardium, and related mouse phenotypes are tumorigenesis and liver/biliary system.

Disease Ontology:9 A primary bacterial infectious disease that is located in lungs, located in lymph nodes, located in pericardium, located in brain, located in pleura or located in gastrointestinal tract, has material basis in mycobacterium tuberculosis, which is transmitted by droplets released into the air when an infected person coughs or sneezes.

NIH Rare Diseases:41 Tuberculosis (tb) is a contagious and often severe airborne disease caused by infection with mycobacterium tuberculosis (mtb). tb typically affects the lungs, but it also can affect any other organ of the body. it is estimated that more than one-third of the world’s population has mtb infection; however, only one in ten people infected with tb bacteria develop active tb disease. early symptoms of active tb can include weight loss, fever, night sweats, and loss of appetite. symptoms involving areas other than the lungs vary, depending upon the organ or area affected. it is usually treated with a regimen of drugs taken for 6 months to 2 years depending on the type of infection, and can be cured in most people. last updated: 5/13/2011

CDC:3 Signs and Symptoms, Transmission, Risk Factors, Exposure, TB Personal Stories…

Wikipedia:63 Tuberculosis, MTB, or TB (short for tubercle bacillus), in the past also called phthisis, phthisis... more...

Aliases & Classifications for Tuberculosis

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Sources:
9Disease Ontology, 41NIH Rare Diseases, 11DISEASES, 43Novoseek, 47Orphanet, 32MedlinePlus, 3CDC, 60UMLS, 10diseasecard, 37NCBI Bookshelf, 55SNOMED-CT, 33MeSH, 34MESH via Orphanet, 61UMLS via Orphanet, 25ICD10
See all sources

Tuberculosis, Aliases & Descriptions:

Name: Tuberculosis 9 41 11 43 47 32 3 60
Tb 41 37 3
Tuberculous Abscess 9 60
 
Tuberculosis, Susceptibility to 10
Kochs Disease 41


Classifications:



Characteristics (Orphanet epidemiological data):

47
tuberculosis:
Inheritance: Not applicable; Prevalence: 1-5/10000 (Europe),1-9/100000 (United States),1-5/10000 (Japan),1-9/100000 (Australia),1-9/100000 (France),1-9/100000 (Finland),1-5/10000 (Hungary),>1/1000 (India),1-9/100000 (Netherlands),1-5/10000 (United Kingdom),1-9/100000 (Norway),1-9/100000 (Sweden),6-9/10000 (China),1-5/10000 (Latin America),>1/1000 (South Africa),1-9/100000 (Denmark),1-9/100000 (Czech Republic),1-9/100000 (Germany),1-5/10000 (Ireland),1-9/100000 (Italy),1-5/10000 (Estonia),1-9/100000 (Greece),1-9/100000 (Iceland),1-9/100000 (Israel),1-5/10000 (Spain),1-5/10000 (Portugal),1-9/100000 (Belgium),1-9/100000 (Austria),6-9/10000 (Algeria),1-5/10000 (Poland),1-5/10000 (Latvia),1-5/10000 (Lithuania),1-5/10000 (Bosnia and Herzegovina),1-5/10000 (Croatia),>1/1000 (Romania),6-9/10000 (Russian Federation),1-5/10000 (Turkey),6-9/10000 (Ukraine),1-9/100000 (Europe); Age of onset: All ages; Age of death: normal life expectancy


External Ids:

Disease Ontology9 DOID:399
MeSH33 D014375
Orphanet47 3389
SNOMED-CT55 15202009
MESH via Orphanet34 D014376
UMLS via Orphanet61 C0041296

Related Diseases for Tuberculosis

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Diseases related to Tuberculosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 728)
idRelated DiseaseScoreTop Affiliating Genes
1pulmonary tuberculosis32.4MBL2, SLC11A1, IFNG, IL4, IL18, IL10
2extrapulmonary tuberculosis32.4ADA
3pleural tuberculosis32.0ADA, CCL2, IFNG, IL18
4crohn's disease31.9IRGM, TNF
5meningitis31.8MBL2, TLR2, ADA
6peritonitis31.7CCL2, ADA, TLR2, TNF
7leprosy31.7TLR2, SLC11A1
8pleurisy31.6ADA
9pneumonia31.6IL10, CCL2, TNF, MBL2, TLR2
10arthritis31.5IL18, VDR, TLR2, SLC11A1, IL10, IL4
11aspergillosis31.3MBL2, TLR2, IFNG
12rheumatoid arthritis31.3IL4, IFNG, CCL2, MBL2, IL12RB1, IL10
13brucellosis31.3SLC11A1
14vasculitis31.2MBL2, CCL2, TNF
15nephritis31.1IL18, CD209, CCL2
16uveitis31.1IL10, CCL2, TNF, IFNG, IL4
17pulmonary sarcoidosis31.1TNF, CCL2, IFNG, IL18, IL12RB1
18leukemia31.1ADA, VDR, TLR2, MBL2, IL4, IFNG
19lepromatous leprosy31.1IL4, IL10, TLR2, IFNG
20tuberculoid leprosy31.1IL10, IFNG
21allergic bronchopulmonary aspergillosis31.1IL4, MBL2
22malaria31.1IL10, IFNG, TNF
23bacteremia31.0MBL2
24inflammatory bowel disease31.0IFNG, CCL2, IL4, IL18, SLC11A1, IL10
25systemic lupus erythematosus31.0TLR2, MBL2, IL12RB1, IL10, IL18, TNF
26synovitis31.0TLR2, IL18, TNF
27lymphopenia30.9IL18, IL10, ADA, IFNG, IL4
28mycobacterium avium complex disease30.9IFNGR1
29psoriasis30.9IL4, IL10, IL18, IFNG, CCL2, TNF
30hepatitis c30.9IFNG, CD209, IL10, IL18, TLR2
31leishmaniasis30.9IL4, IFNG, IFNGR1, IL10, SLC11A1
32kidney disease30.9VDR, CCL2, TNF
33eosinophilia30.8MBL2, IL10, IL18, IL4, IFNG
34colitis30.8IL10, TLR2, IL18, IL4, IFNG, TNF
35schistosomiasis30.8IFNG, IFNGR1, IL4, IL10
36hepatitis b30.8IFNG, MBL2, VDR
37atopy30.7SLC11A1, IFNG, IL18, IL4, IL10, TLR2
38asthma30.7VDR, TLR2, IL4, SLC11A1, MBL2, IL12RB1
39tetanus30.7IL10, TLR2, IFNG, IL4
40visceral leishmaniasis30.7IFNG, IL4, IL10, SLC11A1
41typhoid fever30.7SLC11A1, IFNGR1
42severe combined immunodeficiency30.7IFNG, IL4, ADA
43bacterial meningitis30.7ADA, TLR2
44periodontitis30.7IL10, TNF, CCL2, TLR2, VDR, CD209
45ulcerative colitis30.7IL18, IL10, TNF, IFNG, IL4, IL12RB1
46bronchiectasis30.6TLR2, MBL2
47melanoma30.5ADA, IL4, IL10, TNF, IFNG, VDR
48cutaneous leishmaniasis30.5IFNG, IL10
49rheumatic fever30.5MBL2
50atherosclerosis30.5TNF, TLR2, IL18, IL10, MBL2, CD209

Graphical network of the top 20 diseases related to Tuberculosis:



Diseases related to tuberculosis

Symptoms for Tuberculosis

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Drugs & Therapeutics for Tuberculosis

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Drug clinical trials:

Search ClinicalTrials for Tuberculosis

Search NIH Clinical Center for Tuberculosis

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Tuberculosis

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Anatomical Context for Tuberculosis

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MalaCards organs/tissues related to Tuberculosis:

31
Lung, Testes, T cells, Lymph node, Monocytes, Skin, Liver, Bone, Brain, Neutrophil, Whole blood, Kidney, Bone marrow, Spleen, Heart, Breast, Colon, Thyroid, Eye, Small intestine, Prostate, Nk cells, B cells, Tongue, Pancreas, Tonsil, Pituitary, Ovary, Uterus, Testis, Myeloid, Thymus, Cortex, Retina, Spinal cord, Adrenal gland, Cervix, Endothelial, Pons, Trachea, Appendix, Adrenal cortex, Smooth muscle

FMA organs/tissues related to Tuberculosis:

14
Lungs, Lymph nodes, Pericardium, Brain, Pleura or

Animal Models for Tuberculosis or affiliated genes

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MGI Mouse Phenotypes related to Tuberculosis:

35 (show all 22)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000200610.3TLR2, INHA, TNF, CCL2, IFNGR1, IFNG
2MP:000537010.3TLR2, INHA, TNF, ADA, CCL2, IFNGR1
3MP:000536710.3VDR, TLR2, ADA, IFNGR1, IFNG, IL4
4MP:000536910.2VDR, TLR2, TNF, CCL2, IFNG, IL18
5MP:001077110.2VDR, TLR2, TNF, CCL2, IFNGR1, IFNG
6MP:000537910.2VDR, TLR2, INHA, TNF, IFNGR1, IFNG
7MP:000539010.2VDR, TLR2, INHA, TNF, ADA, CCL2
8MP:000538910.2VDR, INHA, TNF, ADA, CCL2, IFNGR1
9MP:000538210.2VDR, TNF, CCL2, IFNG, IL4, IL10
10MP:000538110.2VDR, TLR2, INHA, TNF, CCL2, IFNGR1
11MP:000538510.2VDR, TLR2, INHA, TNF, TIRAP, CCL2
12MP:000538410.1VDR, TLR2, TNF, ADA, CCL2, IFNGR1
13MP:000539110.1IL10, IL18, IL4, IFNG, CCL2, TNF
14MP:000287310.1TLR2, INHA, ADA, CCL2, IFNG, IL4
15MP:000537810.1VDR, TLR2, INHA, TNF, ADA, CCL2
16MP:000363110.1VDR, TLR2, TNF, CCL2, IFNGR1, IFNG
17MP:001076810.0ADA, TIRAP, TNF, INHA, TLR2, VDR
18MP:00053979.9ADA, TIRAP, TNF, INHA, TLR2, VDR
19MP:00053869.9VDR, TLR2, TNF, CCL2, IFNGR1, IFNG
20MP:00053769.9ADA, IRGM, TIRAP, TNF, INHA, TLR2
21MP:00053889.8TLR2, TNF, ADA, IFNG, IL4, IL10
22MP:00053879.8SLC11A1, VDR, TLR2, INHA, TNF, TIRAP

Publications for Tuberculosis

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Articles related to Tuberculosis:

(show top 50)    (show all 7271)
idTitleAuthorsYear
1
A sensitive urinary lipoarabinomannan test for tuberculosis. (25905641)
2015
2
Potential role of F18 FDG PET-CT as an imaging biomarker for the noninvasive evaluation in uncomplicated skeletal tuberculosis: a prospective clinical observational study. (25070791)
2014
3
Unilateral snow banking in tuberculosis-related intermediate uveitis. (24507077)
2014
4
Pericardial effusion as the first manifestation of occupational tuberculosis in a health care worker. (25720029)
2014
5
Pulmonary hemorrhage complicating Goodpasture's disease in the course of pulmonary tuberculosis. (22826144)
2013
6
Infertility, in vitro fertilization and congenital tuberculosis. (23803676)
2013
7
Resistance to second-line drugs in multidrug-resistant tuberculosis. (23439097)
2013
8
Molecular Epidemiology of Mycobacterium tuberculosis Complex in Singapore, 2006-2012. (24367667)
2013
9
A cross-sectional study of sputum handling by and supervision of patients with pulmonary tuberculosis treated at home in China. (23337789)
2012
10
Cytokine-secreting activity of blood eosinophils in pulmonary tuberculosis. (22866301)
2012
11
Pulmonary tuberculosis associated retinal vasculitis presenting as xanthopsia. (21428751)
2011
12
Isolated porta hepatis lymphadenitis as a presenting feature of tuberculosis. (21841597)
2011
13
Polymorphism in the p2x7 gene increases susceptibility to extrapulmonary tuberculosis in Turkish children. (20661107)
2010
14
Variants in toll-like receptors 2 and 9 influence susceptibility to pulmonary tuberculosis in Caucasians, African-Americans, and West Africans. (19771452)
2010
15
Ultrasonography for diagnosis of abdominal tuberculosis in HIV infected people. (20693594)
2010
16
Primary nodular hepatic tuberculosis mimicking hepatic neoplasia in an immunocompetent host. (20140362)
2009
17
Monocyte chemotactic protein-1 gene polymorphism and monocyte chemotactic protein-1 expression in Chongqing Han children with tuberculosis]. (19573434)
2009
18
Genetic polymorphism of glutathione-S-transferase M1 and T1: a systematic review in Chinese population and a pilot study in smear-positive pulmonary tuberculosis cases of Jilin province]. (19799150)
2009
19
Risk factors and mortality associated with default from multidrug-resistant tuberculosis treatment. (18462099)
2008
20
Simultaneous occurrence of pulmonary tuberculosis and carcinomatous lymphangitis. (17486260)
2007
21
Tumor necrosis factor and tuberculosis. (17502865)
2007
22
Disseminated histoplasmosis and tuberculosis in a patient with HIV infection. (17594164)
2007
23
Tuberculous uveitis: distribution of Mycobacterium tuberculosis in the retinal pigment epithelium. (17159041)
2006
24
Inducible costimulator: a modulator of IFN-gamma production in human tuberculosis. (16670305)
2006
25
Sphingosine kinase 1 (SK1) is recruited to nascent phagosomes in human macrophages: inhibition of SK1 translocation by Mycobacterium tuberculosis. (15749892)
2005
26
Limited good and limited vision: multidrug-resistant tuberculosis and global health policy. (15896895)
2005
27
Morphometric analysis of Th(1) and Th(2) cytokine expression in human pulmonary tuberculosis. (15525561)
2004
28
Clinical characteristics of 110 miliary tuberculosis patients from a low HIV prevalence country. (15141744)
2004
29
The regulatory effect of the supernatant of human airway epithelial cells transfected with DNA vaccine of 30-kilodalton major secretory protein of mycobacterium tuberculosis on the Th1/Th2 balance in mite allergic asthmatics]. (14505522)
2003
30
Allelic distribution of human leukocyte antigen in Iranian patients with pulmonary tuberculosis. (12507823)
2003
31
Pseudo tumoral laryngeal tuberculosis. (12554919)
2003
32
Abdominal tuberculosis mimicking Crohn's disease: a difficult diagnosis. Report of a case. (12032437)
2002
33
Purification and biochemical characterization of Mycobacterium tuberculosis SuhB, an inositol monophosphatase involved in inositol biosynthesis. (11914086)
2002
34
Current concepts on pathogenesis of renal tuberculosis. (11768007)
2001
35
A rare complication of miliary tuberculosis: intestinal perforation. (11301949)
2001
36
Use of systemic immunomodulator xymedone in distructive pulmonary tuberculosis]. (10900981)
2000
37
Renal tuberculosis in children. (10902487)
2000
38
Diagnosis of extrapulmonary tuberculosis by a commercial polymerase chain reaction kit. (9871931)
1998
39
Intestinal perforation due to Mycobacterium tuberculosis in HIV-infected individuals: report of two cases. (8470647)
1993
40
Mycobacterium tuberculosis expresses two chaperonin-60 homologs. (7681982)
1993
41
Bacteriostatic and bactericidal activity of antituberculosis drugs against Mycobacterium tuberculosis, Mycobacterium avium-Mycobacterium intracellulare complex and Mycobacterium kansasii in different growth phases. (1406364)
1992
42
Systemic lupus erythematosus and miliary tuberculosis in a prepubertal girl--a case report. (2152059)
1990
43
Six months' chemotherapy for lymph node tuberculosis. (2616826)
1989
44
Gallstone disease and lithogenicity of bile in intestinal tuberculosis. (7129559)
1982
45
Experiences in the diagnosis and treatment of renal tuberculosis. (13959600)
1962
46
An unusual arteriogram of renal tuberculosis. (14419285)
1960
47
Partial nephrectomy in renal tuberculosis. (13569735)
1957
48
Cyanoacetylhydrazine in therapy of urogenital tuberculosis; test of use as sole medication]. (14395579)
1955
49
Changes in the pulse rate of intestinal tuberculosis patients by abdominal pressure. (13164003)
1954
50
Prognosis of renal tuberculosis treated by nephrectomy. (14909354)
1952

Variations for Tuberculosis

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Clinvar genetic disease variations for Tuberculosis:

6
id Gene Variation Type Significance SNP ID Assembly Location
1CCL2NG_012123.1: g.2493A> Gsingle nucleotide variantPathogenic, risk factorrs1024611GRCh37Chr 17, 32579788: 32579788
2TLR2NM_003264.3(TLR2): c.2258G> A (p.Arg753Gln)single nucleotide variantrisk factorrs5743708GRCh37Chr 4, 154626317: 154626317
3CD209CD209, -871G-Asingle nucleotide variantrisk factor
4SP110NM_080424.2(SP110): c.1274C= (p.Ser425=)single nucleotide variantrisk factorrs3948464GRCh37Chr 2, 231050715: 231050715
5SP110SP110, C-T, INTRON 6single nucleotide variantrisk factor

Expression for genes affiliated with Tuberculosis

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Search GEO for disease gene expression data for Tuberculosis.

Pathways for genes affiliated with Tuberculosis

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Pathways related to Tuberculosis according to GeneCards Suite gene sharing:

(show all 48)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.4CCL2, TNF
210.4IL18, IFNG
310.3TNF, IL18
410.3TNF, VDR
510.3MBL2, TLR2, CD209
6
Show member pathways
thioredoxin pathway36
10.3IFNG, TNF, CCL2
7
Show member pathways
10.3IL18, IFNG, IFNGR1
8
Show member pathways
10.3TNF, IL18, CCL2
910.3TNF, TLR2, IL18
1010.3IFNG, IL10, IL4
1110.3TNF, IFNGR1, IFNG
12
Show member pathways
10.3TNF, IFNGR1, IFNG
13
Show member pathways
10.3TNF, IFNG, IFNGR1
14
Show member pathways
10.3TNF, IFNG, IL10
15
Show member pathways
10.3TNF, TLR2, TIRAP
16
Show member pathways
Calcium signaling in the CD4+ TCR pathway36
10.3IL4, IFNG, TNF
1710.3TNF, VDR, IFNG
1810.3TIRAP, IL10, TNF
1910.3TNF, IFNGR1, IFNG, TLR2
20
Show member pathways
10.2TLR2, IFNG, IL4, IL12RB1
2110.2TNF, TLR2, IFNG, IL10
2210.2IFNG, CCL2, TNF, IL4
23
Show member pathways
Immune response IL 12 induced IFN gamma production58
10.2IL18, IL12RB1, IFNG, IL4
2410.2TNF, IFNG, IL18, IL10
25
Show member pathways
Immune response CD16 signaling in NK cells58
10.2IFNGR1, IL4, IFNG, TNF
26
Show member pathways
BCR signaling pathway36
TCR Signaling Pathway36
10.2IFNG, IL10, IL4, TNF
2710.2TNF, IL10, IL4, IFNG
28
Show member pathways
Immune response MIF in innate immunity response58
10.2IFNG, TNF, TIRAP, IFNGR1
2910.2CCL2, TLR2, TNF, IL18, IFNG
3010.2IL18, TLR2, TNF, CCL2, IFNG
31
Show member pathways
10.2IL4, TLR2, TNF, IFNGR1, IFNG
32
Show member pathways
Type III interferon signaling36
10.2IFNG, IL4, IL12RB1, IL10, IFNGR1
33
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways58
Immune response IL 1 signaling pathway58
10.2TIRAP, CD209, IL18, TLR2, TNF
3410.2IL10, IL18, IL4, IFNG, TNF
3510.1TNF, TLR2, CCL2, IFNG, IL18, IL10
36
Show member pathways
IL23-mediated signaling events36
Immune response IL 10 signaling pathway58
Angiopoietin receptor Tie2-mediated signaling36
Development PDGF signaling via STATs and NF kB58
Development Angiopoietin Tie2 signaling58
10.1TNF, CCL2, IFNG, IL18, IL10, IL12RB1
37
Show member pathways
10.1IL12RB1, CCL2, IL4, IL18, IL10, TNF
38
Show member pathways
10.1IL18, TNF, CCL2, IL4, IL10, IL12RB1
39
Show member pathways
Transcription NF kB signaling pathway58
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response58
10.1TLR2, TNF, TIRAP, IFNGR1, IFNG, IL4
40
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
10.1TLR2, IFNG, TIRAP, CCL2, IFNGR1, IL10
41
Show member pathways
IL27-mediated signaling events36
10.1TLR2, TNF, IFNGR1, IL18, IL10, IL12RB1
42
Show member pathways
10.0IL10, TNF, IFNG, IL4, IL18, IL12RB1
43
Show member pathways
10.0CCL2, IFNG, IL4, IL18, CD209, IFNGR1
44
Show member pathways
10.0IL12RB1, IL10, IL18, IL4, IFNGR1, CCL2
45
Show member pathways
10.0IFNG, IL12RB1, IL10, IFNGR1, TNF, CCL2
46
Show member pathways
10.0TLR2, IL12RB1, TNF, TIRAP, CCL2, IL4
47
Show member pathways
9.9IFNG, IFNGR1, IRGM, TNF, IL18, IL12RB1
489.9CD209, IL18, IFNG, IFNGR1, IL10, VDR

Compounds for genes affiliated with Tuberculosis

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Compounds related to Tuberculosis according to GeneCards Suite gene sharing:

(show top 50)    (show all 142)
idCompoundScoreTop Affiliating Genes
1interferon gamma4310.6IFNG, IL4, TNF, IL10
2tuberculin4310.6MBL2, IL10, IL18, IFNG, ADA
3mip 1alpha4310.6IL10, CCL2, TNF, IL4
4imiquimod43 59 28 1213.6IL18, TLR2, TNF, IFNG, IL10
5amphotericin b4310.6TLR2, IL4, IFNG, ADA
6natalizumab43 1211.6IL10, IFNG, IL18, TNF
7ccl343 2811.6TNF, TLR2, CCL2, IFNG, IL10, IL18
8gm-csf43 2811.6IFNG, IL10, TNF, CCL2, IL18, IL4
9lipoteichoic acid4310.6TLR2, IL18, MBL2, TNF, CCL2, IL10
10polyinosinic-polycytidylic acid4310.5IL4, IFNG, TLR2, TNF, IL18, IL10
11rolipram43 59 2812.5IL4, IL10, IFNG, ADA, TNF
12con a4310.5IL4, MBL2, IL10, IL18, IFNG
13poly(i-c)4310.5IL18, IL4, TLR2, TNF, IFNG
14tarc4310.5IFNG, IL4, IL18, IL10, TNF, CCL2
15ribavirin43 49 1212.5MBL2, ADA, IFNG, IL4, IL10, IL18
16infliximab43 49 1212.5IL10, IFNG, TNF, IL4, IL18
17polymyxin b4310.5TLR2, IL4, IL10, MBL2, IFNG, TNF
18il-124310.5IL18, IFNG, CCL2, TNF, IL10, IL12RB1
19allergens4310.5IL18, IL4, IFNG, IL10, CD209
20pentoxifylline43 1211.5IL10, TNF, IFNG, IL4, IL18
21indoleamine4310.5TNF, IFNG, IL18, IL10
2215-deoxy-delta-12,14-prostaglandin j24310.5CCL2, TNF, IL10, IL4, IFNG
23simvastatin43 49 59 28 24 1215.5TNF, CCL2, TLR2, IFNG, IL4, IL10
24endotoxin4310.5CCL2, IL10, IL18, TLR2, IFNG, TNF
25neopterin4310.5TNF, IL10, IL4, IL18, IFNG, MBL2
26pdtc4310.5TNF, CCL2, IFNG, IL4, IL18
27il 104310.5VDR, TLR2, TNF, CCL2, IFNG, IL4
28tacrolimus43 49 1212.4IL10, VDR, IL4, TLR2, IFNG, TNF
29groalpha4310.4IL10, IL18, CCL2, TNF
30histamine43 28 2412.4IL4, CCL2, TLR2, TNF, ADA, IFNG
31sb 20358043 5911.4TNF, CCL2, IL10, IL18, IL4, IFNG
32ionomycin4310.4IL18, IFNG, TNF, IL10, IL12RB1, IL4
33calcitriol43 59 24 1213.4IL10, IL4, IFNG, TNF, VDR, TLR2
34okt34310.4TNF, IFNG, IL10, IL4
35pge24310.4CCL2, VDR, TLR2, IL10, IL18, IL4
36cyclosporin a43 28 5912.4VDR, IL10, IL18, IL4, ADA, TLR2
37cycloheximide4310.4IL10, IFNG, IL4, VDR, TLR2, TNF
38betaseron4310.4IFNG, IL4, IL10
39vegf4310.3TLR2, ADA, CCL2, IFNG, IL4, TNF
40rantes4310.3IL4, TLR2, GNLY, TNF, CCL2, IFNG
41prednisolone43 28 1212.3IFNG, IL18, TNF, MBL2, IL10
42aspartate4310.3SLC11A1, ADA, MBL2, CCL2, IL18, VDR
43arginine4310.3TLR2, GNLY, ADA, CCL2, IL4, IL18
44nitric oxide43 24 1212.3SLC11A1, IL10, TNF, CCL2, IFNG, IL18
45vitamin d4310.3VDR, CCL2, IL10, MBL2, SLC11A1, TLR2
462,5-oligoadenylate4310.2TNF, ADA, IL10, IFNG
47mycophenolate mofetil43 49 1212.2TNF, IFNG, IL10, IL18
48dexamethasone43 49 28 1213.2VDR, TLR2, TNF, ADA, CCL2, IFNG
49etanercept43 49 1212.1IL18, IL10, IFNG, TNF
50actinomycin d439.8VDR, TLR2, IL4, IFNG, CCL2, TNF

GO Terms for genes affiliated with Tuberculosis

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Cellular components related to Tuberculosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:000998610.2MBL2, ADA, TNF, TLR2
2external side of plasma membraneGO:000989710.2ADA, TLR2, IFNG, IL4, IL12RB1, TNF
3phagocytic cupGO:000189110.1IRGM, TNF
4extracellular regionGO:000557610.0INHA, TNF, CCL2, IL18, MBL2, CD209
5extracellular spaceGO:00056159.9IFNG, ADA, TNF, GNLY, IL4, IL18

Biological processes related to Tuberculosis according to GeneCards Suite gene sharing:

(show top 50)    (show all 65)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of vitamin D biosynthetic processGO:006055710.7IFNG, TNF
2defense response to protozoanGO:004283210.7SLC11A1, IL4, IFNG
3type 2 immune responseGO:004209210.7IL10, IL4, IL18
4positive regulation of MHC class II biosynthetic processGO:004534810.7IL10, IL4, IFNG
5positive regulation of NF-kappaB import into nucleusGO:004234610.7TNF, IL18, TLR2
6positive regulation of chemokine biosynthetic processGO:004508010.7IL4, TNF, IFNG
7protein import into nucleus, translocationGO:000006010.7TNF, SLC11A1, IFNG
8positive regulation of interleukin-12 productionGO:003273510.7IFNG, TIRAP, TLR2
9positive regulation of interleukin-18 productionGO:003274110.7TLR2, TNF
10receptor biosynthetic processGO:003280010.7TNF, IL10
11regulation of isotype switchingGO:004519110.7IL4, IL10
12positive regulation of cytokine secretionGO:005071510.7TNF, IL10, TLR2
13response to activityGO:001482310.7CCL2, TNF, IL10
14positive regulation of activated T cell proliferationGO:004210410.7IL4, IL18, IL12RB1
15cellular response to bacterial lipopeptideGO:007122110.7TIRAP, TLR2
16positive regulation of nitric oxide biosynthetic processGO:004542910.7IFNG, TLR2, TNF
17lipopolysaccharide-mediated signaling pathwayGO:003166310.7IL18, CCL2, TLR2, TNF
18positive regulation of calcidiol 1-monooxygenase activityGO:006055910.7IFNG, TNF
19positive regulation of tumor necrosis factor productionGO:003276010.7TLR2, TIRAP, IFNG
20cellular response to organic cyclic compoundGO:007140710.7CCL2, IL18, TNF
21positive regulation of interferon-gamma productionGO:003272910.7SLC11A1, TNF, IL18, IL12RB1
22positive regulation of B cell proliferationGO:003089010.7IL4, TIRAP, ADA
23positive regulation of chemokine (C-X-C motif) ligand 2 productionGO:0200034310.7TIRAP, TNF
24negative regulation of cytokine secretion involved in immune responseGO:000274010.7IL10, TNF
25defense response to Gram-positive bacteriumGO:005083010.7MBL2, TNF, TLR2, TIRAP
26positive regulation of isotype switching to IgG isotypesGO:004830410.6IL4, IFNG
27response to hypoxiaGO:000166610.6CCL2, ADA, TNF, TLR2
28humoral immune responseGO:000695910.6IFNG, CCL2, TNF
29cellular response to lipoteichoic acidGO:007122310.6TIRAP, TLR2
30cell surface receptor signaling pathwayGO:000716610.6INHA, IFNG, TIRAP, CCL2
31positive regulation of interleukin-6 biosynthetic processGO:004541010.6IFNG, TIRAP
32defense response to bacteriumGO:004274210.6GNLY, IL10, IFNG, MBL2, SLC11A1
33response to drugGO:004249310.6TNF, CCL2, IL10, IFNG, IL4
34MAPK cascadeGO:000016510.6CCL2, TNF, IL18
35negative regulation of interleukin-17 productionGO:003270010.6IFNG, TLR2
36cytokine-mediated signaling pathwayGO:001922110.6IL12RB1, IFNG, IFNGR1, CCL2
37cellular response to lipopolysaccharideGO:007122210.6IL10, IFNG, CCL2
38negative regulation of growth of symbiont in hostGO:004413010.6IFNG, IL10, TNF, MBL2, TIRAP, TLR2
39positive regulation of T-helper 1 type immune responseGO:000282710.5SLC11A1, IL12RB1
40response to glucocorticoidGO:005138410.5IL10, TNF, CCL2
41signal transductionGO:000716510.5CCL2, IL12RB1, IFNGR1, INHA, TLR2, SP110
42positive regulation of transcription from RNA polymerase II promoterGO:004594410.5VDR, TLR2, IL4, SLC11A1, TNF, IFNG
43inflammatory responseGO:000695410.5SLC11A1, CCL2, IRGM, TIRAP, IL10, TNF
44organ morphogenesisGO:000988710.4TNF, CCL2, VDR
45positive regulation of nitric-oxide synthase biosynthetic processGO:005177010.4CCL2, TLR2
46viral genome replicationGO:001907910.4CD209, CCL2
47positive regulation of sequence-specific DNA binding transcription factor activityGO:005109110.3IL10, IL4, TNF
48innate immune responseGO:004508710.3CD209, MBL2, TLR2, TIRAP, IRGM
49positive regulation of synaptic transmissionGO:005080610.3CCL2, TNF
50negative regulation of nitric oxide biosynthetic processGO:004501910.1IL4, IL10

Molecular functions related to Tuberculosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1mannose bindingGO:000553710.4CD209, MBL2
2cytokine activityGO:00051259.8IL10, IL18, IL4, IFNG, TNF, INHA

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