TB
MCID: TBR010
MIFTS: 82

Tuberculosis (TB) malady

Infectious category

Summaries for Tuberculosis

Sources:
8Disease Ontology, 43NIH Rare Diseases, 34MedlinePlus, 3CDC, 64Wikipedia, 47OMIM, 33MalaCards
See all sources

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MedlinePlus:34 Tuberculosis (tb) is a disease caused by bacteria called mycobacterium tuberculosis. the bacteria usually attack the lungs, but they can also damage other parts of the body. tb spreads through the air when a person with tb of the lungs or throat coughs, sneezes, or talks. if you have been exposed, you should go to your doctor for tests. you are more likely to get tb if you have a weak immune system. symptoms of tb in the lungs may include a bad cough that lasts 3 weeks or longer weight loss loss of appetite coughing up blood or mucus weakness or fatigue fever night sweats skin tests, blood tests, x-rays, and other tests can tell if you have tb. if not treated properly, tb can be deadly. you can usually cure active tb by taking several medicines for a long period of time. nih: national institute of allergy and infectious diseases

MalaCards: Tuberculosis, also known as tuberculous abscess, is related to pulmonary tuberculosis and pleural tuberculosis. An important gene associated with Tuberculosis is IFNGR1 (interferon gamma receptor 1), and among its related pathways are Allograft rejection and Immune System. The drugs aminosalicylic acid and antitubercular agents and the compounds ionomycin and sb 203580 have been mentioned in the context of this disorder. Affiliated tissues include lungs, brain and pericardium, and related mouse phenotypes are immune system and hematopoietic system.

Disease Ontology:8 A primary bacterial infectious disease that is located in lungs, located in lymph nodes, located in pericardium, located in brain, located in pleura or located in gastrointestinal tract, has material basis in mycobacterium tuberculosis, which is transmitted by droplets released into the air when an infected person coughs or sneezes.

NIH Rare Diseases:43 Tuberculosis (tb) is a contagious and often severe airborne disease caused by infection with mycobacterium tuberculosis (mtb). tb typically affects the lungs, but it also can affect any other organ of the body. it is estimated that more than one-third of the world’s population has mtb infection; however, only one in ten people infected with tb bacteria develop active tb disease. early symptoms of active tb can include weight loss, fever, night sweats, and loss of appetite. symptoms involving areas other than the lungs vary, depending upon the organ or area affected. it is usually treated with a regimen of drugs taken for 6 months to 2 years depending on the type of infection, and can be cured in most people. last updated: 5/13/2011

CDC:3 TB is a disease caused by a bacterium called Mycobacterium tuberculosis. The bacteria usually attack the lungs, but TB bacteria can attack any part of the body such as the kidney, spine, and brain. If not treated properly, TB disease can be fatal. TB disease was once the leading cause of death in the United States. Learn More »

Wikipedia:64 Tuberculosis, MTB, or TB (short for tubercle bacillus), in the past also called Phthisis or Phthisis... more...

Description from OMIM:47 607948

Aliases & Classifications for Tuberculosis

Sources:
8Disease Ontology, 43NIH Rare Diseases, 47OMIM, 10DISEASES, 45Novoseek, 34MedlinePlus, 61UMLS, 9diseasecard, 39NCBI Bookshelf, 35MeSH, 57SNOMED-CT, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious


Aliases & Descriptions:

tuberculosis 8 43 47 10 45 34 61
tuberculous abscess 8 61
tuberculoma 8 61
tb 43 39
tuberculosis, susceptibility to 9
kochs disease 43


External Ids:

Disease Ontology8 DOID:399
MeSH35 D014375
SNOMED-CT57 15202009

Related Diseases for Tuberculosis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Tuberculosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 653)
idRelated DiseaseScoreTop Affiliating Genes
1pulmonary tuberculosis31.9IL18, IL10, INHA, VDR, MBL2, IFNGR1
2pleural tuberculosis31.2ADA, IL18, IFNG
3arthritis30.9TLR2, IFNG, TNF, CISH, VDR, IL10
4hepatitis c30.6TLR2, IFNG, TNF, CISH, IL10, IL18
5crohn's disease30.6TNF, IRGM
6pulmonary sarcoidosis30.5IFNG, TNF, IL18, IL12RB1
7systemic lupus erythematosus30.4TLR2, IFNG, IFNGR1, MBL2, TNF, IL10
8vasculitis30.4TNF, MBL2
9aspergillosis30.4TLR2, IFNG, MBL2
10nephritis30.3IL18
11uveitis30.3IFNG, TNF, CISH, IL10, IL4
12asthma30.2SLC11A1, IL4, IL12RB1, IL18, IL10, VDR
13lepromatous leprosy30.2IL4, IL10, IFNG, TLR2
14viral hepatitis30.2CISH, TLR2
15adenocarcinoma30.2ADA, INHA
16bronchiectasis30.2MBL2, TLR2
17paracoccidioidomycosis30.2IL10
18allergic bronchopulmonary aspergillosis30.2MBL2, IL4
19melioidosis30.2TLR2
20tuberculoid leprosy30.1IL10, IFNG
21ankylosing spondylitis30.1TNF
22hepatitis b30.1TLR2, IFNG, MBL2, IL10, IL18
23sepsis30.0TLR2, MBL2, TNF, CISH, IL10, IL18
24synovitis30.0TLR2, TNF, IL18
25mycobacterium avium complex disease30.0IFNGR1
26atopy29.9TLR2, IFNG, IL10, IL18, IL4, SLC11A1
27septic shock29.9TLR2, MBL2, TNF, IL10
28ulcerative colitis29.9IRGM, TNF
29infertility29.9INHA
30aplastic anemia29.9IFNG
31intraocular lymphoma29.8IL10
32allergic asthma29.8TLR2, IFNG, IFNGR1, CISH, IL10, IL18
33atherosclerosis29.8TLR2, MBL2, TNF, IL10, IL18
34visceral leishmaniasis29.8SLC11A1, IL4, IL10, IFNG
35measles29.8TLR2, GNLY
36acute pancreatitis29.8IL10, IL18
37adenoma29.8VDR, INHA
38colorectal cancer29.8VDR
39lyme disease29.8TLR2
40viral infectious disease29.6TLR2, IFNG, IFNGR1, GNLY, MBL2, TNF
41cork-handlers' disease29.6TLR2, IFNGR1, MBL2, TNF, IL10, IL12RB1
42allergic rhinitis29.6TLR2, IFNG, MBL2, IL10, IL18, IL4
43behcet's disease29.6ADA, IL18, TNF, MBL2
44common variable immune deficiency29.6IL4, IL10, MBL2
45lupus nephritis29.6MBL2, IL10, IL18
46type 1 diabetes29.6IFNG, IL10, IL4
47cutaneous leishmaniasis29.6IL10, IFNG
48atypical mycobacteriosis, familial29.6IL12RB1, IFNGR1
49cystic fibrosis29.6MBL2
50rheumatic fever29.6MBL2

Graphical network of the top 20 diseases related to Tuberculosis:



Diseases related to tuberculosis

Clinical Features for Tuberculosis

Sources:
47OMIM
See all sources

Clinical features from OMIM:

607948

Drugs & Therapeutics for Tuberculosis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Tuberculosis

Drug clinical trials:

Search ClinicalTrials for Tuberculosis

Search NIH Clinical Center for Tuberculosis

Search CenterWatch for Tuberculosis

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Tuberculosis

Anatomical Context for Tuberculosis

Sources:
33MalaCards, 14FMA
See all sources

MalaCards organs/tissues related to Tuberculosis:

33
Skin, Ovary, Liver, Tongue, Spinal cord, Brain, Kidney, Lymph node, Lung, Spleen, Uterus, Bone marrow, Whole blood, Thymus, Cortex, Retina, Heart, Smooth muscle, Skeletal muscle, Small intestine, Colon, Pancreas, Thyroid, Adrenal gland, Breast, Prostate, Testis, Cervix, Tonsil, Myeloid, Monocytes, Nk cells, T cells, B cells, Fetal brain, Parietal lobe, Temporal lobe, Pons, Fetal liver, Fetal lung, Bronchial epithelium, Appendix, Fetal thyroid, Adrenal cortex, Pituitary

FMA organs/tissues related to Tuberculosis:

14
Lungs, Brain, Pericardium, Lymph nodes, Pleura or

Animal Models for Tuberculosis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Tuberculosis

Sources:
51PubMed
See all sources

Articles related to Tuberculosis:

(show top 50)    (show all 6949)
idTitleAuthorsYear
1
Reasons for defaulting from drug-resistant tuberculosis treatment in Armenia: a quantitative and qualitative study. (24429307)
2014
2
Association between vitamin D deficiency and tuberculosis in a Korean population. (24365556)
2014
3
Safe Re-administration of Tumor Necrosis Factor-alpha (TNFI+) Inhibitors in Patients with Rheumatoid Arthritis or Ankylosing Spondylitis Who Developed Active Tuberculosis on Previous Anti-TNFI+ Therapy. (24431903)
2014
4
Resistance to second-line drugs in multidrug-resistant tuberculosis - Authors' reply. (23439099)
2013
5
Human IL10 gene repression by Rev-erbI+ ameliorates Mycobacterium tuberculosis clearance. (23449984)
2013
6
Correction: Comparative Evaluation of GenoType MTBDRplus Line Probe Assay with Solid Culture Method in Early Diagnosis of Multidrug Resistant Tuberculosis (MDR-TB) at a Tertiary Care Centre in India. (24146735)
2013
7
Tuberculosis, HIV, and type 2 diabetes mellitus: a neglected priority. (24429192)
2013
8
Discovery and identification of serum potential biomarkers for pulmonary tuberculosis using iTRAQ-coupled two-dimensional LC-MS/MS. (24339194)
2013
9
Tuberculosis in the course of sarcoidosis treatment: is genotyping necessary for personalized therapy? (23557270)
2013
10
Tuberculosis-spoligo-rifampin-isoniazid typing: an all-in-one assay technique for surveillance and control of multidrug-resistant tuberculosis on Luminex devices. (23966495)
2013
11
A case of cervical tuberculosis mimicking cervical carcinoma. (24431658)
2013
12
Mycobacterium tuberculosis modulates macrophage lipid-sensing nuclear receptors PPARI^ and TR4 for survival. (22544925)
2012
13
Prevalence of tuberculosis in patients with anthracosis: study on 150 subjects. (22369298)
2012
14
Atypical lung parenchymal bronchogenic cyst complicated by tuberculosis infection. (23061072)
2012
15
Targeted drug-resistance testing strategy for multidrug-resistant tuberculosis detection, Lima, Peru, 2005-2008. (21392434)
2011
16
NRAMP1 polymorphism and susceptibility to lung tuberculosis in Surabaya, Indonesia. (21710855)
2011
17
Coronary artery bypass in a patient with Swyer-James syndrome due to pulmonary tuberculosis. (20382603)
2010
18
Constrictive pericarditis in a renal transplant recipient with tuberculosis. (21072157)
2010
19
Association between FokI polymorphism in vitamin D receptor gene and susceptibility to spinal tuberculosis in Chinese Han population. (20430254)
2010
20
SLC11A1 (Formerly NRAMP1) gene polymorphisms associated with pediatric tuberculosis in China. (19193106)
2009
21
A case of pulmonary tuberculosis and tuberculous pleuritis during treatment with etanercept for rheumatoid arthritis]. (19260544)
2009
22
Management of pediatric multidrug-resistant tuberculosis and latent tuberculosis infections in New York City from 1995 to 2003. (18756183)
2008
23
Isolated splenic tuberculosis presenting with splenomegaly and pyrexia of unknown origin. (18366419)
2008
24
Cytokine profile in fatal human immunodeficiency virus tuberculosis Epstein-Barr virus associated hemophagocytic syndrome. (17893313)
2007
25
Mortality associated with central nervous system tuberculosis. (17920686)
2007
26
Esophageal anthracosis with endobronchial tuberculosis: case report. (17140923)
2006
27
Direct detection of rifampin- and isoniazid-resistant Mycobacterium tuberculosis in auramine-rhodamine-positive sputum specimens by real-time PCR. (15071008)
2004
28
Extrapulmonary tuberculosis, clinical presentation and outcome. (15235693)
2004
29
Mycobacterium tuberculosis glycosylated phosphatidylinositol causes phagosome maturation arrest. (12702770)
2003
30
Monocyte chemotactic protein-1 production in patients with active pulmonary tuberculosis and tuberculous pleurisy. (12861395)
2003
31
Choroidal tuberculoma in miliary tuberculosis. (12652241)
2003
32
Imaging of esophageal tuberculosis: a review of 23 cases. (12752007)
2003
33
5' dinucleotide repeat polymorphism of NRAMP1 and susceptibility to tuberculosis among Caucasian patients in Houston, Texas. (12234138)
2002
34
Concurrent upregulation of urokinase plasminogen activator receptor and CD11b during tuberculosis and experimental endotoxemia. (11447203)
2001
35
Gastric outlet obstruction due to duodenal tuberculosis: a case report. (11918239)
2001
36
Intestinal tuberculosis in patients with fever of unknown origin in Egypt. (17219858)
1999
37
CD4+ T-lymphocytopenia in pulmonary tuberculosis. (9526202)
1998
38
Paradoxical progression of tuberculous lesions during chemotherapy of central nervous system tuberculosis. Report of four cases. (7616286)
1995
39
Ethanol suppresses Mycobacteria tuberculosis-induced mRNA for nitric oxide synthase in alveolar macrophages, in vivo. (7542849)
1995
40
Pleural thickening in patients with pleural tuberculosis. (8162780)
1994
41
Tuberculous fasciitis and tenosynovitis. An unusual presentation of miliary tuberculosis. (8425379)
1993
42
Assessment of tuberculosis recurrence risk in phenotyping haptoglobin in patients with post-tuberculous residual changes in the lungs]. (1528844)
1992
43
Duodenal tuberculosis presenting as duodenal obstruction. (2613652)
1989
44
On the pathogenesis of renal tuberculosis with special reference to the role of local factors. A clinical and experimental study. (5154511)
1971
45
Miliary tuberculosis in a nonagenarian. (5762656)
1969
46
Acute miliary tuberculosis presenting as a haematological problem. (5700119)
1968
47
Partial nephrectomy in the solitary kidney. II. Experience with 20 cases of renal tuberculosis. (5677040)
1968
48
COMPARATIVE STUDY OF IN VIVO AND IN VITRO GROWN MYCOBACTERIUM TUBERCULOSIS. 3. LIPID COMPOSITION. (14268684)
1965
49
Chemotherapy of renal tuberculosis]. (13203795)
1954
50
Abdominal Tuberculosis in Children. (21312477)
1926

Genetic Variations for Tuberculosis

Expression for genes affiliated with Tuberculosis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Tuberculosis

Search GEO for disease gene expression data for Tuberculosis.

Pathways for genes affiliated with Tuberculosis

Sources:
30KEGG, 52QIAGEN, 54Reactome, 38NCBI BioSystems Database, 53R&D Systems, 12EMD Millipore, 4Cell Signaling Technology
See all sources

Pathways related to Tuberculosis according to GeneCards/GeneDecks:

(show all 37)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.9IFNG, IFNGR1, TNF, IL10, IL18, IL12RB1
2
Hide members
11.9TLR2, IFNG, IFNGR1, MBL2, CISH, IL18
3
Hide members
11.9TLR2, IFNG, IFNGR1, TNF, IL10, IL18
411.9TLR2, IFNG, IFNGR1, TNF, VDR, IL10
511.7IFNG, IFNGR1, CISH, IL10, IL12RB1, IL4
6
Hide members
11.7TLR2, IFNG, IFNGR1, TNF, IL18, IL4
7
Hide members
11.7IL4, IL12RB1, IL18, IL10, TNF, TLR2
8
Hide members
11.5IL12RB1, IL18, IRGM, IFNGR1, TLR2
9
Hide members
11.5TLR2, IFNG, IFNGR1, TNF, IL10
10
Hide members
11.5TLR2, IFNG, IFNGR1, TNF, IL4
1111.5IFNG, TNF, IL10, IL18, IL4
12
Development PDGF signaling via STATs and NF-kB
Hide members
11.5IFNG, TNF, IL10, IL18, IL12RB1
13
Hide members
11.3IFNG, IFNGR1, CISH, IL18
1411.3TLR2, IFNG, IFNGR1, TNF
15
Immune response Bacterial infections in normal airways
11.3TNF, IFNGR1, IFNG, TLR2
1611.3IFNG, TNF, IL10, IL18
17
Hide members
11.3IL4, IL12RB1, IL18, IFNG
1811.3IL10, TNF, IFNG, TLR2
1911.3TLR2, IFNG, TNF, IL18
20
Hide members
11.3TLR2, TNF, IL18, P2RX7
2111.1IL18, IFNGR1, IFNG
22
Development Thrombopoetin signaling via JAK-STAT pathway
Hide members
11.1IFNG, CISH, IL4
23
Hide members
11.1TNF, IFNGR1, IFNG
2411.1IFNG, IL10, IL4
25
Hide members
11.1IL10, TNF, IFNG
26
Hide members
11.1IL4, TNF, IFNG
2711.1IL18, TNF, TLR2
28
Transcription Role of VDR in regulation of genes involved in osteoporosis
Hide members
11.1IFNG, TNF, VDR
29
Hide members
11.1P2RX7, IL18, TNF
3010.9IFNGR1, IFNG
31
Hide members
10.9IFNGR1, IL12RB1
32
Hide members
10.9IL12RB1, CISH
33
Hide members
10.9IFNG, IL4
3410.9IL18, TLR2
3510.9IL18, TLR2
3610.9VDR, TNF
3710.7IL12RB1

Compounds for genes affiliated with Tuberculosis

Sources:
45Novoseek, 60Tocris Bioscience, 11DrugBank, 24HMDB, 50PharmGKB, 29IUPHAR, 2BitterDB
See all sources

Compounds related to Tuberculosis according to GeneCards/GeneDecks:

(show top 50)    (show all 89)
idCompoundScoreTop Affiliating Genes
1ionomycin4512.6GNLY, IL4, IL18, IL12RB1, IL10, TNF
2sb 20358045 6013.6TNF, P2RX7, IFNG, IL4, IL18, IL10
3vegf4512.5ADA, IL4, MBL2, TLR2, IL10, IFNG
4nitric oxide45 11 2414.5IL10, MBL2, IL18, SLC11A1, CISH, IFNG
5polymyxin b4512.4IL10, P2RX7, IL4, TNF, MBL2, IFNG
6il 104512.4IFNG, TNF, TLR2, VDR, IL10, IL18
7neopterin4512.4IFNG, TNF, IL10, IL18, IL4, MBL2
8tacrolimus45 50 1114.4IL4, IL18, IL10, VDR, TNF, IFNG
9histamine45 29 2414.3IFNG, IL10, TLR2, TNF, IL18, IL4
10il-124512.2IL4, IL12RB1, IL10, IFNG, TNF, IL18
11polyinosinic-polycytidylic acid4512.2TLR2, IFNG, TNF, IL10, IL4, IL18
12ribavirin45 50 1114.2ADA, IL18, IL10, MBL2, IFNG, IL4
13simvastatin45 50 60 29 11 2417.1IL4, IL10, TNF, IFNG, TLR2, IL18
14calcitriol45 60 11 2415.1TLR2, IFNG, IL10, TNF, VDR, IL4
15tuberculin4512.0IFNG, MBL2, IL10, IL18, ADA
16rantes4512.0TNF, MBL2, IL4, TLR2, IFNG
17imiquimod45 29 60 1114.9IL18, TNF, IFNG, TLR2, IL10
18con a4511.9IL18, MBL2, IL4, IL10, IFNG
19lipoteichoic acid4511.9IL18, IL10, TNF, MBL2, TLR2
20poly(i-c)4511.9TLR2, IFNG, TNF, IL18, IL4
21infliximab45 50 1113.9IFNG, TNF, IL10, IL18, IL4
22tarc4511.9IL4, IL18, IL10, TNF, IFNG
23ccl345 2912.9IL18, TNF, IL10, IFNG, TLR2
24dexamethasone45 50 29 1114.8CISH, VDR, TLR2, ADA
25cyclosporin a45 29 6013.7IFNG, ADA, P2RX7, VDR
26interferon gamma4511.7IL4, IL10, TNF, IFNG
27natalizumab45 1112.7IFNG, TNF, IL10, IL18
28okt34511.7IFNG, TNF, IL10, IL4
29arginine4511.6TLR2, IL4, IL18, VDR, GNLY, ADA
302,5-oligoadenylate4511.6TNF, ADA, IFNG, IL10
31etanercept45 50 1113.6IL10, IL18, TNF, IFNG
32anti-fungal4511.6MBL2, GNLY, IFNG, TLR2
33peptidoglycan45 2912.5TLR2, MBL2, TNF, IL10
34ivig4511.5IL4, IFNG, TNF, IL10
35ifn-alpha4511.5IFNG, IL18, IL10, CISH
36gm-csf45 2912.5IFNG, IL10, TNF
3715-deoxy-delta-12,14-prostaglandin j24511.5IFNG, IL10, TNF, IL4
38allergens4511.5IL4, IL18, IL10, IFNG
39betaseron4511.4IFNG, IL10, IL4
40alpha-galactosylceramide4511.4IFNG, IL4, IL10
41chloroquine45 2 50 29 1115.3IL10, IL18, IL4, TNF
42pentoxifylline45 1112.3IL4, IL18
43mip 1alpha4511.2IL4, IL10, TNF
44thalidomide45 50 60 1114.2IL18, TNF, IL10, IFNG
45cycloheximide4511.2IL18, TLR2
46glatiramer acetate45 1112.2IFNG, IL10, IL4
47rolipram45 60 2913.1ADA
48amphotericin b4511.0ADA
49prednisolone45 29 1113.0MBL2
50pdtc4510.7IL18

GO Terms for genes affiliated with Tuberculosis

Sources:
16Gene Ontology
See all sources

Cellular components related to Tuberculosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561511.8IFNG, GNLY, MBL2, TNF, IL10, IL18
2external side of plasma membraneGO:00989711.8ADA, TLR2, IFNG, TNF, IL12RB1, IL4
3phagocytic cupGO:00189110.9IRGM, TNF

Biological processes related to Tuberculosis according to GeneCards/GeneDecks:

(show all 33)
idNameGO IDScoreTop Affiliating Genes
1inflammatory responseGO:00695412.3TLR2, TNF, IRGM, IL10, IL18, P2RX7
2positive regulation of transcription from RNA polymerase II promoterGO:04594412.3IFNG, IL4, VDR, SLC11A1, TNF, TLR2
3negative regulation of growth of symbiont in hostGO:04413011.9TLR2, IFNG, TNF, MBL2, IL10
4defense response to bacteriumGO:04274211.9IL10, SLC11A1, GNLY, IFNG, MBL2
5response to drugGO:04249311.8IFNG, TNF, IL10, IL4, P2RX7
6signal transductionGO:00716511.7VDR, IL12RB1, TLR2, SP110, INHA, IFNGR1
7positive regulation of interferon-gamma productionGO:03272911.7SLC11A1, IL12RB1, IL18, TNF
8defense response to Gram-positive bacteriumGO:05083011.7TNF, P2RX7, MBL2, TLR2
9type 2 immune responseGO:04209211.5IL18, IL4, IL10
10positive regulation of MHC class II biosynthetic processGO:04534811.5IL4, IL10, IFNG
11positive regulation of chemokine biosynthetic processGO:04508011.5IL4, TNF, IFNG
12positive regulation of chemokine productionGO:03272211.5TLR2, IL18, TNF
13defense response to protozoanGO:04283211.5IL4, SLC11A1, IFNG
14positive regulation of activated T cell proliferationGO:04210411.5IL4, IL12RB1, IL18
15positive regulation of NF-kappaB import into nucleusGO:04234611.4TLR2, TNF, IL18
16protein import into nucleus, translocationGO:00006011.4SLC11A1, IFNG, TNF
17positive regulation of cytokine secretionGO:05071511.4TLR2, IL10, TNF
18lipopolysaccharide-mediated signaling pathwayGO:03166311.4IL18, TNF, TLR2
19positive regulation of nitric oxide biosynthetic processGO:04542911.4TLR2, IFNG, TNF
20positive regulation of tumor necrosis factor productionGO:03276011.4IL18, IFNG, TLR2
21positive regulation of interleukin-6 productionGO:03275511.3P2RX7, TNF, TLR2
22positive regulation of vitamin D biosynthetic processGO:06055711.2TNF, IFNG
23positive regulation of sequence-specific DNA binding transcription factor activityGO:05109111.2IL4, TNF, IL10
24receptor biosynthetic processGO:03280011.2TNF, IL10
25regulation of isotype switchingGO:04519111.1IL10, IL4
26positive regulation of calcidiol 1-monooxygenase activityGO:06055911.1IFNG, TNF
27negative regulation of cytokine secretion involved in immune responseGO:00274011.1TNF, IL10
28positive regulation of isotype switching to IgG isotypesGO:04830411.1IFNG, IL4
29negative regulation of interleukin-17 productionGO:03270011.0TLR2, IFNG
30positive regulation of T-helper 1 type immune responseGO:00282711.0IL12RB1, SLC11A1
31positive regulation of membrane protein ectodomain proteolysisGO:05104410.9IFNG, TNF
32negative regulation of nitric oxide biosynthetic processGO:04501910.8IL4, IL10
33negative regulation of interleukin-12 productionGO:03269510.6IL10, TLR2

Molecular functions related to Tuberculosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00512511.7IL4, IL18, IL10, INHA, TNF, IFNG

Products for genes affiliated with Tuberculosis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Tuberculosis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet