TB
MCID: TBR010
MIFTS: 87

Tuberculosis (TB) malady

Rare diseases, Infectious diseases, Respiratory diseases, Cardiovascular diseases, Neuronal diseases categories
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Summaries for Tuberculosis

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MedlinePlus:33 Tuberculosis (tb) is a disease caused by bacteria called mycobacterium tuberculosis. the bacteria usually attack the lungs, but they can also damage other parts of the body. tb spreads through the air when a person with tb of the lungs or throat coughs, sneezes, or talks. if you have been exposed, you should go to your doctor for tests. you are more likely to get tb if you have a weak immune system. symptoms of tb in the lungs may include a bad cough that lasts 3 weeks or longer weight loss loss of appetite coughing up blood or mucus weakness or fatigue fever night sweats skin tests, blood tests, x-rays, and other tests can tell if you have tb. if not treated properly, tb can be deadly. you can usually cure active tb by taking several medicines for a long period of time. nih: national institute of allergy and infectious diseases

MalaCards based summary: Tuberculosis, also known as tuberculous abscess, is related to pulmonary tuberculosis and extrapulmonary tuberculosis. An important gene associated with Tuberculosis is IFNGR1 (interferon gamma receptor 1), and among its related pathways are LDL Oxidation in Atherogenesis and Hypertrophy Model. The drugs antitubercular agents and ethambutol and the compounds interferon gamma and tuberculin have been mentioned in the context of this disorder. Affiliated tissues include lungs, lymph nodes and pericardium, and related mouse phenotypes are tumorigenesis and liver/biliary system.

Disease Ontology:8 A primary bacterial infectious disease that is located in lungs, located in lymph nodes, located in pericardium, located in brain, located in pleura or located in gastrointestinal tract, has material basis in mycobacterium tuberculosis, which is transmitted by droplets released into the air when an infected person coughs or sneezes.

NIH Rare Diseases:42 Tuberculosis (tb) is a contagious and often severe airborne disease caused by infection with mycobacterium tuberculosis (mtb). tb typically affects the lungs, but it also can affect any other organ of the body. it is estimated that more than one-third of the world’s population has mtb infection; however, only one in ten people infected with tb bacteria develop active tb disease. early symptoms of active tb can include weight loss, fever, night sweats, and loss of appetite. symptoms involving areas other than the lungs vary, depending upon the organ or area affected. it is usually treated with a regimen of drugs taken for 6 months to 2 years depending on the type of infection, and can be cured in most people. last updated: 5/13/2011

CDC:3 TB is a disease caused by a bacterium called Mycobacterium tuberculosis. The bacteria usually attack the lungs, but TB bacteria can attack any part of the body such as the kidney, spine, and brain. If not treated properly, TB disease can be fatal. TB disease was once the leading cause of death in the United States. Learn More »

Wikipedia:65 Tuberculosis, MTB, or TB (short for tubercle bacillus), in the past also called phthisis, phthisis... more...

Description from OMIM:46 607948

Aliases & Classifications for Tuberculosis

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Tuberculosis, Aliases & Descriptions:

Name: Tuberculosis 8 42 46 10 44 33 62
Tuberculous Abscess 8 62
Kochs Disease 42 62
 
Tb 42 38
Tuberculosis, Susceptibility to 9


Classifications:



External Ids:

Disease Ontology8 DOID:399
MeSH34 D014375
SNOMED-CT57 15202009

Related Diseases for Tuberculosis

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Diseases related to Tuberculosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 756)
idRelated DiseaseScoreTop Affiliating Genes
1pulmonary tuberculosis32.6SLC11A1, MBL2, IL12RB1, IL10, VDR, TLR2
2extrapulmonary tuberculosis32.4ADA
3pleural tuberculosis32.1ADA, CCL2, IFNG, IL18
4crohn's disease31.9TNF, IRGM
5meningitis31.9TLR2, ADA, MBL2
6peritonitis31.8TLR2, TNF, ADA, CCL2
7leprosy31.7TLR2, SLC11A1
8sarcoidosis31.6TNF, ADA, CCL2, IFNGR1, IFNG, IL18
9pneumonia31.6TLR2, TNF, CCL2, IL10, MBL2
10pleurisy31.6ADA
11aspergillosis31.4TLR2, IFNG, MBL2
12arthritis31.3VDR, TLR2, TNF, CISH, CCL2, IFNG
13vasculitis31.3TNF, CCL2, MBL2
14brucellosis31.2SLC11A1
15nephritis31.2CCL2, IL18, CD209
16pulmonary sarcoidosis31.2TNF, CCL2, IFNG, IL18, IL12RB1
17systemic lupus erythematosus31.2MBL2, IL12RB1, IL10, IL18, TLR2, TNF
18bacteremia31.1MBL2
19lepromatous leprosy31.1TLR2, IFNG, IL4, IL10
20rheumatoid arthritis31.1MBL2, SLC11A1, IL12RB1, IL10, IL18, TLR2
21allergic bronchopulmonary aspergillosis31.1IL4, MBL2
22tuberculoid leprosy31.1IFNG, IL10
23inflammatory bowel disease31.1VDR, TLR2, TNF, CCL2, IFNG, IL4
24malaria31.0SLC11A1, IL10, TLR2, TNF, TIRAP, IFNGR1
25lymphopenia31.0ADA, IFNG, IL4, IL18, IL10
26psoriasis31.0VDR, TLR2, TNF, CCL2, IFNG, IL4
27hepatitis c31.0TLR2, IFNG, IL18, IL10, CD209
28leishmaniasis31.0IFNGR1, IFNG, IL4, IL10, SLC11A1
29mycobacterium avium complex disease30.9IFNGR1
30hepatitis b30.9MBL2, IFNG, VDR
31synovitis30.9IL18, TNF, TLR2
32eosinophilia30.9IFNG, IL4, IL18, IL10, MBL2
33colitis30.9TLR2, TNF, IFNG, IL4, IL18, IL10
34uveitis30.9TNF, CISH, CCL2, IFNG, IL4, IL10
35leukemia30.9VDR, TLR2, TNF, CISH, ADA, IFNG
36schistosomiasis30.9IL10, IL4, IFNG, IFNGR1
37septic shock30.8TLR2, TNF, IL10, MBL2
38atopy30.8TLR2, IFNG, IL4, IL18, IL10, SLC11A1
39ulcerative colitis30.8TLR2, TNF, IFNG, IL4, IL18, IL10
40periodontitis30.8VDR, TLR2, TNF, CCL2, IL10, CD209
41tuberculosis, protection against30.8TIRAP, IFNG
42visceral leishmaniasis30.7SLC11A1, IL10, IL4, IFNG
43severe combined immunodeficiency30.7ADA, IFNG, IL4
44bacterial meningitis30.7ADA, TLR2
45bronchiectasis30.7TLR2, MBL2
46sepsis30.6TLR2, TNF, CISH, CCL2, IL18, IL10
47atherosclerosis30.6TLR2, TNF, CCL2, IL18, IL10, MBL2
48cutaneous leishmaniasis30.5IFNG, IL10
49asthma30.5VDR, TLR2, TNF, CISH, CCL2, IFNG
50type 1 diabetes mellitus30.5IFNG, IL4, IL10

Graphical network of the top 20 diseases related to Tuberculosis:



Diseases related to tuberculosis

Symptoms for Tuberculosis

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Clinical features from OMIM:

607948

Drugs & Therapeutics for Tuberculosis

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Drug clinical trials:

Search ClinicalTrials for Tuberculosis

Search NIH Clinical Center for Tuberculosis

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Tuberculosis

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Anatomical Context for Tuberculosis

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MalaCards organs/tissues related to Tuberculosis:

32
Lung, Testes, T cells, Lymph node, Monocytes, Skin, Brain, Kidney, Liver, Bone, Neutrophil, Whole blood, Bone marrow, Heart, Spleen, Colon, Breast, Thyroid, Small intestine, Prostate, Nk cells, B cells, Tongue, Eye, Pancreas, Tonsil, Pituitary, Adrenal gland, Ovary, Uterus, Testis, Myeloid, Thymus, Cortex, Retina, Spinal cord, Cervix, Endothelial, Pons, Trachea, Appendix, Adrenal cortex, Smooth muscle

FMA organs/tissues related to Tuberculosis:

14
Lungs, Lymph nodes, Pericardium, Brain, Pleura or

Animal Models for Tuberculosis or affiliated genes

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MGI Mouse Phenotypes related to Tuberculosis:

36 (show all 22)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000200610.5TLR2, INHA, TNF, CCL2, IFNGR1, IFNG
2MP:000537010.4TLR2, INHA, TNF, ADA, CCL2, IFNGR1
3MP:000536710.4VDR, TLR2, ADA, IFNGR1, IFNG, IL4
4MP:000537910.4VDR, TLR2, INHA, TNF, CISH, IFNGR1
5MP:000539010.4VDR, TLR2, INHA, TNF, ADA, CCL2
6MP:001077110.4VDR, TLR2, TNF, CCL2, IFNGR1, IFNG
7MP:000538110.4VDR, TLR2, INHA, TNF, CCL2, IFNGR1
8MP:000538810.3TLR2, TNF, CISH, ADA, IFNG, IL4
9MP:000538910.3VDR, INHA, TNF, ADA, CCL2, IFNGR1
10MP:000538510.3VDR, TLR2, INHA, TNF, TIRAP, CCL2
11MP:000536910.3VDR, TLR2, TNF, CCL2, IFNG, IL18
12MP:000538410.3VDR, TLR2, TNF, ADA, CCL2, IFNGR1
13MP:000537810.2VDR, TLR2, INHA, TNF, ADA, CCL2
14MP:001076810.2ADA, TIRAP, TNF, INHA, TLR2, VDR
15MP:000539110.2CCL2, IFNG, IL4, IL18, IL10, TNF
16MP:000538210.2VDR, TNF, CCL2, IFNG, IL4, IL10
17MP:000363110.2VDR, TLR2, TNF, CCL2, IFNGR1, IFNG
18MP:000539710.1ADA, CISH, TIRAP, TNF, INHA, TLR2
19MP:000287310.1TLR2, INHA, ADA, CCL2, IFNG, IL4
20MP:000537610.1IRGM, CISH, TIRAP, TNF, INHA, TLR2
21MP:000538710.1SLC11A1, VDR, TLR2, INHA, TNF, TIRAP
22MP:00053869.9VDR, TLR2, TNF, CCL2, IFNGR1, IFNG

Publications for Tuberculosis

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Articles related to Tuberculosis:

(show top 50)    (show all 7130)
idTitleAuthorsYear
1
Potential role of F18 FDG PET-CT as an imaging biomarker for the noninvasive evaluation in uncomplicated skeletal tuberculosis: a prospective clinical observational study. (25070791)
2014
2
Unilateral snow banking in tuberculosis-related intermediate uveitis. (24507077)
2014
3
Pulmonary hemorrhage complicating Goodpasture's disease in the course of pulmonary tuberculosis. (22826144)
2013
4
Infertility, in vitro fertilization and congenital tuberculosis. (23803676)
2013
5
Resistance to second-line drugs in multidrug-resistant tuberculosis. (23439097)
2013
6
Molecular Epidemiology of Mycobacterium tuberculosis Complex in Singapore, 2006-2012. (24367667)
2013
7
Incidence of paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome and impact on patient outcome. (24367678)
2013
8
A cross-sectional study of sputum handling by and supervision of patients with pulmonary tuberculosis treated at home in China. (23337789)
2012
9
Cytokine-secreting activity of blood eosinophils in pulmonary tuberculosis. (22866301)
2012
10
Pulmonary tuberculosis associated retinal vasculitis presenting as xanthopsia. (21428751)
2011
11
Isolated porta hepatis lymphadenitis as a presenting feature of tuberculosis. (21841597)
2011
12
Polymorphism in the p2x7 gene increases susceptibility to extrapulmonary tuberculosis in Turkish children. (20661107)
2010
13
Variants in toll-like receptors 2 and 9 influence susceptibility to pulmonary tuberculosis in Caucasians, African-Americans, and West Africans. (19771452)
2010
14
Ultrasonography for diagnosis of abdominal tuberculosis in HIV infected people. (20693594)
2010
15
Primary nodular hepatic tuberculosis mimicking hepatic neoplasia in an immunocompetent host. (20140362)
2009
16
Monocyte chemotactic protein-1 gene polymorphism and monocyte chemotactic protein-1 expression in Chongqing Han children with tuberculosis]. (19573434)
2009
17
Genetic polymorphism of glutathione-S-transferase M1 and T1: a systematic review in Chinese population and a pilot study in smear-positive pulmonary tuberculosis cases of Jilin province]. (19799150)
2009
18
Risk factors and mortality associated with default from multidrug-resistant tuberculosis treatment. (18462099)
2008
19
Simultaneous occurrence of pulmonary tuberculosis and carcinomatous lymphangitis. (17486260)
2007
20
Tumor necrosis factor and tuberculosis. (17502865)
2007
21
Disseminated histoplasmosis and tuberculosis in a patient with HIV infection. (17594164)
2007
22
Tuberculous uveitis: distribution of Mycobacterium tuberculosis in the retinal pigment epithelium. (17159041)
2006
23
Inducible costimulator: a modulator of IFN-gamma production in human tuberculosis. (16670305)
2006
24
Sphingosine kinase 1 (SK1) is recruited to nascent phagosomes in human macrophages: inhibition of SK1 translocation by Mycobacterium tuberculosis. (15749892)
2005
25
Limited good and limited vision: multidrug-resistant tuberculosis and global health policy. (15896895)
2005
26
Morphometric analysis of Th(1) and Th(2) cytokine expression in human pulmonary tuberculosis. (15525561)
2004
27
Clinical characteristics of 110 miliary tuberculosis patients from a low HIV prevalence country. (15141744)
2004
28
The regulatory effect of the supernatant of human airway epithelial cells transfected with DNA vaccine of 30-kilodalton major secretory protein of mycobacterium tuberculosis on the Th1/Th2 balance in mite allergic asthmatics]. (14505522)
2003
29
Allelic distribution of human leukocyte antigen in Iranian patients with pulmonary tuberculosis. (12507823)
2003
30
Pseudo tumoral laryngeal tuberculosis. (12554919)
2003
31
Abdominal tuberculosis mimicking Crohn's disease: a difficult diagnosis. Report of a case. (12032437)
2002
32
Purification and biochemical characterization of Mycobacterium tuberculosis SuhB, an inositol monophosphatase involved in inositol biosynthesis. (11914086)
2002
33
Current concepts on pathogenesis of renal tuberculosis. (11768007)
2001
34
A rare complication of miliary tuberculosis: intestinal perforation. (11301949)
2001
35
Clinical aspects of miliary tuberculosis in Saudi adults. (10751072)
2000
36
Use of systemic immunomodulator xymedone in distructive pulmonary tuberculosis]. (10900981)
2000
37
Renal tuberculosis in children. (10902487)
2000
38
Diagnosis of extrapulmonary tuberculosis by a commercial polymerase chain reaction kit. (9871931)
1998
39
Intestinal perforation due to Mycobacterium tuberculosis in HIV-infected individuals: report of two cases. (8470647)
1993
40
Mycobacterium tuberculosis expresses two chaperonin-60 homologs. (7681982)
1993
41
Bacteriostatic and bactericidal activity of antituberculosis drugs against Mycobacterium tuberculosis, Mycobacterium avium-Mycobacterium intracellulare complex and Mycobacterium kansasii in different growth phases. (1406364)
1992
42
Systemic lupus erythematosus and miliary tuberculosis in a prepubertal girl--a case report. (2152059)
1990
43
Six months' chemotherapy for lymph node tuberculosis. (2616826)
1989
44
Gallstone disease and lithogenicity of bile in intestinal tuberculosis. (7129559)
1982
45
Experiences in the diagnosis and treatment of renal tuberculosis. (13959600)
1962
46
An unusual arteriogram of renal tuberculosis. (14419285)
1960
47
Partial nephrectomy in renal tuberculosis. (13569735)
1957
48
Cyanoacetylhydrazine in therapy of urogenital tuberculosis; test of use as sole medication]. (14395579)
1955
49
Changes in the pulse rate of intestinal tuberculosis patients by abdominal pressure. (13164003)
1954
50
Prognosis of renal tuberculosis treated by nephrectomy. (14909354)
1952

Variations for Tuberculosis

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Clinvar genetic disease variations for Tuberculosis:

6
id Gene Name Type Significance SNP ID Assembly Location
1CCL2NG_012123.1: g.2493A> Gsingle nucleotide variantPathogenicrs1024611GRCh37Chr 17, 32579788: 32579788
2TLR2NM_003264.3(TLR2): c.2258G> A (p.Arg753Gln)single nucleotide variantrisk factorrs5743708GRCh37Chr 4, 154626317: 154626317
3CD209CD209, -336A-Gsingle nucleotide variantprotective
4CD209CD209, -871G-Asingle nucleotide variantrisk factor
5SP110NM_080424.2(SP110): c.1274C= (p.Ser425=)single nucleotide variantrisk factorrs3948464GRCh37Chr 2, 231050715: 231050715
6SP110SP110, C-T, INTRON 6single nucleotide variantrisk factor

Expression for genes affiliated with Tuberculosis

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Expression patterns in normal tissues for genes affiliated with Tuberculosis

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Pathways for genes affiliated with Tuberculosis

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Pathways related to Tuberculosis according to GeneCards/GeneDecks:

(show top 50)    (show all 51)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.4CCL2, TNF
210.4IL18, IFNG
310.4IL18, TNF
410.4TNF, VDR
5
Show member pathways
10.4IFNGR1, IFNG, IL18
6
Show member pathways
Development Thrombopoetin signaling via JAK STAT pathway60
10.4IL4, IFNG, CISH
7
Show member pathways
10.4IFNG, IFNGR1, TNF
8
Show member pathways
10.4TNF, IFNGR1, IFNG
910.4TNF, IFNGR1, IFNG
10
Show member pathways
thioredoxin pathway37
10.4TNF, CCL2, IFNG
1110.4CD209, MBL2, TLR2
12
Show member pathways
10.3IL18, CCL2, TNF
1310.3TLR2, TNF, IL18
1410.3IFNG, IL4, IL10
15
Show member pathways
10.3IL10, IFNG, TNF
16
Show member pathways
10.3TIRAP, TNF, TLR2
17
Show member pathways
Calcium signaling in the CD4+ TCR pathway37
10.3TNF, IFNG, IL4
18
Show member pathways
10.3IL18, IFNG, IFNGR1, CISH
1910.3VDR, TNF, IFNG
2010.3IL10, TIRAP, TNF
2110.3TLR2, TNF, IFNGR1, IFNG
22
Show member pathways
10.3IL12RB1, IL4, IFNG, TLR2
2310.3TLR2, TNF, IFNG, IL10
24
Show member pathways
Immune response CD16 signaling in NK cells60
10.3IL4, IFNG, IFNGR1, TNF
2510.3IL4, IFNG, CCL2, TNF
26
Show member pathways
Immune response MIF in innate immunity response60
10.3IFNG, IFNGR1, TIRAP, TNF
27
Show member pathways
Immune response IL 12 induced IFN gamma production60
10.3IFNG, IL4, IL18, IL12RB1
2810.3TNF, IFNG, IL18, IL10
2910.3IL10, IL4, IFNG, TNF
30
Show member pathways
BCR signaling pathway37
TCR Signaling Pathway37
10.3TNF, IFNG, IL4, IL10
31
Show member pathways
10.3TLR2, TNF, IFNGR1, IFNG, IL4
3210.3TLR2, TNF, CCL2, IFNG, IL18
3310.3TLR2, TNF, CCL2, IFNG, IL18
34
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways60
Immune response IL 1 signaling pathway60
10.3TLR2, TNF, TIRAP, IL18, CD209
3510.2TNF, IFNG, IL4, IL18, IL10
36
Show member pathways
Type III interferon signaling37
10.2CISH, IFNGR1, IFNG, IL4, IL10, IL12RB1
3710.2TLR2, TNF, CCL2, IFNG, IL18, IL10
38
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
10.2TLR2, TNF, TIRAP, IFNGR1, IFNG, IL4
39
Show member pathways
IL23-mediated signaling events37
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling37
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
10.2TNF, CCL2, IFNG, IL18, IL10, IL12RB1
40
Show member pathways
10.2TNF, CCL2, IL4, IL18, IL10, IL12RB1
41
Show member pathways
10.2TNF, CCL2, IL4, IL18, IL10, IL12RB1
42
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
10.2TLR2, TNF, TIRAP, CCL2, IFNGR1, IFNG
43
Show member pathways
IL27-mediated signaling events37
10.2TLR2, TNF, IFNGR1, IFNG, IL18, IL10
44
Show member pathways
10.2TNF, IFNGR1, IFNG, IL4, IL18, IL10
45
Show member pathways
10.2TLR2, TNF, CCL2, IFNGR1, IFNG, IL4
46
Show member pathways
10.1TNF, CCL2, IFNGR1, IFNG, IL4, IL18
47
Show member pathways
10.1TLR2, TNF, TIRAP, CCL2, IL4, IL18
48
Show member pathways
10.1TNF, CISH, CCL2, IFNGR1, IFNG, IL4
49
Show member pathways
10.1IL12RB1, TLR2, IL10, IL18, IL4, IFNG
5010.1VDR, TLR2, TNF, TIRAP, IFNGR1, IFNG

Compounds for genes affiliated with Tuberculosis

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Compounds related to Tuberculosis according to GeneCards/GeneDecks:

(show top 50)    (show all 144)
idCompoundScoreTop Affiliating Genes
1interferon gamma4410.7IFNG, IL4, IL10, TNF
2tuberculin4410.7ADA, IFNG, IL18, MBL2, IL10
3imiquimod44 61 28 1113.7IL18, TNF, IL10, TLR2, IFNG
4gm-csf44 2811.7IL4, IL10, IL18, IFNG, CCL2, TNF
5lipoteichoic acid4410.7IL18, MBL2, CCL2, TLR2, TNF, IL10
6ccl344 2811.6TNF, CCL2, IL10, IL18, TLR2, IFNG
7mip 1alpha4410.6TNF, CCL2, IL10, IL4
8polyinosinic-polycytidylic acid4410.6TLR2, IL18, IFNG, IL4, IL10, TNF
9tarc4410.6TNF, IL18, IL10, CCL2, IFNG, IL4
10con a4410.6IL10, MBL2, IL18, IL4, IFNG
11polymyxin b4410.6MBL2, IL4, IL10, TLR2, TNF, CCL2
12rolipram44 61 2812.6TNF, ADA, IL10, IL4, IFNG
13ribavirin44 50 1112.6ADA, IFNG, IL4, IL18, IL10, MBL2
14poly(i-c)4410.6TLR2, TNF, IFNG, IL4, IL18
15natalizumab44 1111.6IFNG, IL18, IL10, TNF
16il-124410.6IL12RB1, IL10, IL18, IL4, IFNG, CCL2
17amphotericin b4410.6IL4, IFNG, ADA, TLR2
18simvastatin44 50 61 28 24 1115.6TNF, CCL2, IFNG, IL4, TLR2, IL18
19infliximab44 50 1112.6IFNG, TNF, IL4, IL18, IL10
20neopterin4410.6IFNG, ADA, TNF, MBL2, IL10, IL18
21pentoxifylline44 1111.6IL18, IL4, TNF, IL10, IFNG
22il 104410.6IFNG, TLR2, TNF, CCL2, VDR, IL18
2315-deoxy-delta-12,14-prostaglandin j24410.6TNF, CCL2, IFNG, IL4, IL10
24ionomycin4410.6TLR2, IFNG, TNF, IL4, IL10, IL18
25allergens4410.6IFNG, IL4, CD209, IL10, IL18
26endotoxin4410.6TLR2, TNF, CCL2, IFNG, IL18, IL10
27tacrolimus44 50 1112.6IL18, IL4, TNF, TLR2, VDR, IL10
28sb 20358044 6111.6VDR, IL10, IL18, IL4, IFNG, CCL2
29histamine44 28 2412.6IL18, IL4, IFNG, CCL2, TNF, TLR2
30indoleamine4410.5TNF, IL10, IL18, IFNG
31rantes4410.5CD209, MBL2, IL10, IL18, IL4, IFNG
32pdtc4410.5IFNG, IL4, TNF, CCL2, IL18
33pge24410.5IFNG, IL10, IL4, TNF, TLR2, VDR
34cyclosporin a44 28 6112.5IL18, TNF, IL4, IFNG, ADA, IL10
35groalpha4410.5IL10, IL18, TNF, CCL2
36calcitriol44 61 24 1113.5IL4, IL10, TNF, VDR, IFNG, TLR2
37cycloheximide4410.5IFNG, TNF, TLR2, VDR, IL4, IL18
38nitric oxide44 24 1112.5MBL2, IL18, IFNG, CCL2, TNF, TLR2
39okt34410.5IL10, IL4, IFNG, TNF
40vegf4410.5MBL2, CCL2, ADA, TNF, TLR2, IFNG
41aspartate4410.4VDR, CCL2, IL10, ADA, IL18, MBL2
42betaseron4410.4IFNG, IL4, IL10
43prednisolone44 28 1112.4MBL2, IL18, IL10, IFNG, TNF
44dexamethasone44 50 28 1113.4TNF, CISH, ADA, CCL2, IFNG, IL18
45vitamin d4410.3MBL2, SLC11A1, CCL2, TLR2, VDR, IL10
462,5-oligoadenylate4410.3IFNG, IL10, ADA, TNF
47mycophenolate mofetil44 50 1112.3TNF, IFNG, IL10, IL18
48tyrosine4410.3IFNGR1, IL4, IL18, CISH, TIRAP, INHA
49etanercept44 50 1112.2IL10, IFNG, TNF, IL18
50actinomycin d449.9TLR2, CCL2, IFNG, TNF, VDR, IL4

GO Terms for genes affiliated with Tuberculosis

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Cellular components related to Tuberculosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:00998610.3MBL2, ADA, TNF, TLR2
2external side of plasma membraneGO:00989710.3IL12RB1, TLR2, TNF, ADA, IFNG, IL4
3extracellular spaceGO:00561510.1TNF, ADA, CCL2, IFNG, IL4, IL18
4phagocytic cupGO:00189110.1IRGM, TNF
5extracellular regionGO:00557610.1INHA, TNF, CCL2, IFNG, IL18, MBL2

Biological processes related to Tuberculosis according to GeneCards/GeneDecks:

(show top 50)    (show all 65)
idNameGO IDScoreTop Affiliating Genes
1type 2 immune responseGO:04209210.8IL4, IL18, IL10
2positive regulation of MHC class II biosynthetic processGO:04534810.8IFNG, IL4, IL10
3defense response to protozoanGO:04283210.8SLC11A1, IL4, IFNG
4positive regulation of vitamin D biosynthetic processGO:06055710.8IFNG, TNF
5positive regulation of NF-kappaB import into nucleusGO:04234610.8TLR2, TNF, IL18
6positive regulation of chemokine biosynthetic processGO:04508010.8IL4, IFNG, TNF
7lipopolysaccharide-mediated signaling pathwayGO:03166310.8IL18, CCL2, TNF, TLR2
8protein import into nucleus, translocationGO:00006010.8TNF, IFNG, SLC11A1
9positive regulation of activated T cell proliferationGO:04210410.8IL12RB1, IL18, IL4
10positive regulation of interleukin-12 productionGO:03273510.8IFNG, TIRAP, TLR2
11positive regulation of cytokine secretionGO:05071510.8TLR2, TNF, IL10
12cellular response to bacterial lipopeptideGO:07122110.8TLR2, TIRAP
13response to activityGO:01482310.8IL10, CCL2, TNF
14positive regulation of nitric oxide biosynthetic processGO:04542910.7TLR2, TNF, IFNG
15positive regulation of calcidiol 1-monooxygenase activityGO:06055910.7TNF, IFNG
16regulation of isotype switchingGO:04519110.7IL4, IL10
17positive regulation of interferon-gamma productionGO:03272910.7TNF, IL18, IL12RB1, SLC11A1
18cellular response to organic cyclic compoundGO:07140710.7IL18, CCL2, TNF
19positive regulation of tumor necrosis factor productionGO:03276010.7TLR2, TIRAP, IFNG
20positive regulation of interleukin-18 productionGO:03274110.7TLR2, TNF
21receptor biosynthetic processGO:03280010.7TNF, IL10
22defense response to Gram-positive bacteriumGO:05083010.7MBL2, TIRAP, TNF, TLR2
23defense response to bacteriumGO:04274210.7IFNG, IL10, MBL2, SLC11A1
24positive regulation of B cell proliferationGO:03089010.7TIRAP, ADA, IL4
25positive regulation of chemokine (C-X-C motif) ligand 2 productionGO:200034310.7TIRAP, TNF
26response to hypoxiaGO:00166610.7CCL2, ADA, TNF, TLR2
27negative regulation of cytokine secretion involved in immune responseGO:00274010.7IL10, TNF
28positive regulation of isotype switching to IgG isotypesGO:04830410.7IL4, IFNG
29cell surface receptor signaling pathwayGO:00716610.7INHA, TIRAP, CCL2, IFNG
30humoral immune responseGO:00695910.7TNF, CCL2, IFNG
31response to drugGO:04249310.7TNF, CCL2, IFNG, IL4, IL10
32cellular response to lipoteichoic acidGO:07122310.7TLR2, TIRAP
33negative regulation of growth of symbiont in hostGO:04413010.6MBL2, TLR2, TNF, TIRAP, IFNG, IL10
34cytokine-mediated signaling pathwayGO:01922110.6CCL2, IFNGR1, IFNG, IL12RB1
35positive regulation of interleukin-6 biosynthetic processGO:04541010.6TIRAP, IFNG
36signal transductionGO:00716510.6VDR, SP110, TLR2, INHA, CCL2, IFNGR1
37MAPK cascadeGO:00016510.6IL18, CCL2, TNF
38negative regulation of interleukin-17 productionGO:03270010.6IFNG, TLR2
39positive regulation of transcription from RNA polymerase II promoterGO:04594410.6VDR, TLR2, TNF, IFNG, IL4, IL10
40cellular response to lipopolysaccharideGO:07122210.6IL10, IFNG, CCL2
41inflammatory responseGO:00695410.6TLR2, TNF, TIRAP, IRGM, CCL2, IL18
42response to glucocorticoidGO:05138410.6TNF, CCL2, IL10
43positive regulation of T-helper 1 type immune responseGO:00282710.6IL12RB1, SLC11A1
44organ morphogenesisGO:00988710.5CCL2, TNF, VDR
45viral genome replicationGO:01907910.4CD209, CCL2
46innate immune responseGO:04508710.4TLR2, TIRAP, IRGM, MBL2, CD209
47positive regulation of sequence-specific DNA binding transcription factor activityGO:05109110.4TNF, IL4, IL10
48negative regulation of nitric oxide biosynthetic processGO:04501910.4IL10, IL4
49positive regulation of synaptic transmissionGO:05080610.3CCL2, TNF
50positive regulation of nitric-oxide synthase biosynthetic processGO:05177010.1CCL2, TLR2

Molecular functions related to Tuberculosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mannose bindingGO:00553710.4CD209, MBL2
2cytokine activityGO:0051259.9IL10, IL18, IL4, IFNG, TNF, INHA

Products for genes affiliated with Tuberculosis

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  • Antibodies
  • Proteins
  • Lysates

Sources for Tuberculosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet