TB
MCID: TBR010
MIFTS: 83

Tuberculosis (TB) malady

Rare diseases, Infectious diseases, Respiratory diseases, Cardiovascular diseases, Neuronal diseases categories
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Summaries for Tuberculosis

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8Disease Ontology, 43NIH Rare Diseases, 34MedlinePlus, 4CDC, 65Wikipedia, 47OMIM, 33MalaCards
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MedlinePlus:34 Tuberculosis (tb) is a disease caused by bacteria called mycobacterium tuberculosis. the bacteria usually attack the lungs, but they can also damage other parts of the body. tb spreads through the air when a person with tb of the lungs or throat coughs, sneezes, or talks. if you have been exposed, you should go to your doctor for tests. you are more likely to get tb if you have a weak immune system. symptoms of tb in the lungs may include a bad cough that lasts 3 weeks or longer weight loss loss of appetite coughing up blood or mucus weakness or fatigue fever night sweats skin tests, blood tests, x-rays, and other tests can tell if you have tb. if not treated properly, tb can be deadly. you can usually cure active tb by taking several medicines for a long period of time. nih: national institute of allergy and infectious diseases

MalaCards: Tuberculosis, also known as tuberculous abscess, is related to pulmonary tuberculosis and extrapulmonary tuberculosis. An important gene associated with Tuberculosis is IFNGR1 (interferon gamma receptor 1), and among its related pathways are Immune response IL 12 signaling pathway and Hypertrophy Model. The drugs antitubercular agents and ethambutol and the compounds interferon gamma and betaseron have been mentioned in the context of this disorder. Affiliated tissues include lungs, pleura or and lymph nodes, and related mouse phenotypes are tumorigenesis and liver/biliary system.

Disease Ontology:8 A primary bacterial infectious disease that is located in lungs, located in lymph nodes, located in pericardium, located in brain, located in pleura or located in gastrointestinal tract, has material basis in mycobacterium tuberculosis, which is transmitted by droplets released into the air when an infected person coughs or sneezes.

NIH Rare Diseases:43 Tuberculosis (tb) is a contagious and often severe airborne disease caused by infection with mycobacterium tuberculosis (mtb). tb typically affects the lungs, but it also can affect any other organ of the body. it is estimated that more than one-third of the world’s population has mtb infection; however, only one in ten people infected with tb bacteria develop active tb disease. early symptoms of active tb can include weight loss, fever, night sweats, and loss of appetite. symptoms involving areas other than the lungs vary, depending upon the organ or area affected. it is usually treated with a regimen of drugs taken for 6 months to 2 years depending on the type of infection, and can be cured in most people. last updated: 5/13/2011

CDC:4 TB is a disease caused by a bacterium called Mycobacterium tuberculosis. The bacteria usually attack the lungs, but TB bacteria can attack any part of the body such as the kidney, spine, and brain. If not treated properly, TB disease can be fatal. TB disease was once the leading cause of death in the United States. Learn More »

Wikipedia:65 Tuberculosis, MTB, or TB (short for tubercle bacillus), in the past also called phthisis, phthisis... more...

Description from OMIM:47 607948

Aliases & Classifications for Tuberculosis

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8Disease Ontology, 9diseasecard, 43NIH Rare Diseases, 47OMIM, 10DISEASES, 45Novoseek, 39NCBI Bookshelf, 34MedlinePlus, 62UMLS, 58SNOMED-CT, 35MeSH, 25ICD10
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Classifications:



Aliases & Descriptions:

tuberculosis 8 43 47 10 45 34 62
tuberculous abscess 8 62
tb 43 39
tuberculosis, susceptibility to 9
kochs disease 43
tuberculoma 62


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Disease Ontology8 DOID:399
MeSH35 D014375
SNOMED-CT58 15202009

Related Diseases for Tuberculosis

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17GeneCards, 18GeneDecks
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Diseases related to Tuberculosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 723)
idRelated DiseaseScoreTop Affiliating Genes
1pulmonary tuberculosis31.9VDR, TLR2, INHA, SLC11A1, MBL2, IL12RB1
2extrapulmonary tuberculosis31.7ADA
3pleural tuberculosis31.3ADA, IFNG, IL18
4crohn's disease31.1IRGM, TNF
5meningitis31.1TLR2, ADA, MBL2
6peritonitis31.1ADA, TNF, TLR2
7sarcoidosis31.0TNF, SLC11A1, IL12RB1, IL18, IFNG, IFNGR1
8pneumonia30.9TLR2, TNF, IL10, MBL2
9arthritis30.9VDR, TLR2, TNF, CISH, IFNG, IL4
10leprosy30.9SLC11A1, TLR2
11pleurisy30.8ADA
12rheumatoid arthritis30.8TLR2, TNF, CISH, ADA, IFNG, IL4
13aspergillosis30.6MBL2, IFNG, TLR2
14brucellosis30.5SLC11A1
15systemic lupus erythematosus30.5MBL2, IL12RB1, IL10, IL18, IL4, IFNG
16pulmonary sarcoidosis30.5TNF, IFNG, IL18, IL12RB1
17uveitis30.4TNF, CISH, IFNG, IL4, IL10
18leukemia30.4VDR, TLR2, TNF, CISH, ADA, IFNG
19allergic bronchopulmonary aspergillosis30.4IL4, MBL2
20bacteremia30.4MBL2
21inflammatory bowel disease30.4VDR, TLR2, TNF, IFNG, IL4, IL18
22tuberculoid leprosy30.4IL10, IFNG
23lepromatous leprosy30.3TLR2, IFNG, IL4, IL10
24otitis media30.3MBL2, TLR2
25psoriasis30.3VDR, TLR2, TNF, IFNG, IL4, IL18
26bronchiectasis30.3MBL2, TLR2
27lymphopenia30.3ADA, IFNG, IL4, IL18, IL10
28malaria30.2SLC11A1, IL10, IFNG, IFNGR1, TIRAP, TNF
29hepatitis b30.2MBL2, IFNG, VDR
30synovitis30.2IL18, TNF, TLR2
31leishmaniasis30.2IFNGR1, IFNG, IL4, IL10, SLC11A1
32hepatitis c30.2TLR2, IFNG, IL18, IL10
33eosinophilia30.2IFNG, IL4, IL18, IL10, MBL2
34asthma30.2SLC11A1, MBL2, IL12RB1, IL10, IL18, IL4
35mycobacterium avium complex disease30.2IFNGR1
36schistosomiasis30.1IFNGR1, IFNG, IL4, IL10
37periodontitis30.1IL10, TNF, TLR2, VDR
38septic shock30.1MBL2, IL10, TNF, TLR2
39sepsis30.1TLR2, TNF, CISH, IL18, IL10, MBL2
40bacterial meningitis30.1TLR2, ADA
41atopy30.1TLR2, IFNG, IL4, IL18, IL10, SLC11A1
42ulcerative colitis30.1TLR2, TNF, IFNG, IL4, IL18, IL10
43tuberculosis, protection against30.0TIRAP, IFNG
44visceral leishmaniasis30.0SLC11A1, IL10, IL4, IFNG
45severe combined immunodeficiency30.0ADA, IFNG, IL4
46atherosclerosis29.9TLR2, TNF, IL18, IL10, MBL2
47melanoma29.9VDR, INHA, TNF, CISH, ADA, IFNG
48cutaneous leishmaniasis29.8IFNG, IL10
49atypical mycobacteriosis, familial29.8IL12RB1, IFNGR1
50rheumatic fever29.8MBL2

Graphical network of the top 20 diseases related to Tuberculosis:



Diseases related to tuberculosis

Symptoms for Tuberculosis

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47OMIM
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Clinical features from OMIM:

607948

Drugs & Therapeutics for Tuberculosis

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Tuberculosis

Search NIH Clinical Center for Tuberculosis

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Tuberculosis

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Anatomical Context for Tuberculosis

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33MalaCards, 14FMA
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MalaCards organs/tissues related to Tuberculosis:

33
Lung, Testes, T cells, Lymph node, Monocytes, Skin, Brain, Kidney, Liver, Bone, Whole blood, Bone marrow, Colon, Heart, Breast, Spleen, Thyroid, B cells, Prostate, Tongue, Small intestine, Nk cells, Eye, Tonsil, Pituitary, Adrenal gland, Uterus, Testis, Myeloid, Ovary, Pancreas, Cervix, Appendix, Cortex, Adrenal cortex, Retina, Thymus, Spinal cord, Pons, Smooth muscle

FMA organs/tissues related to Tuberculosis:

14
Lungs, Pleura or, Lymph nodes, Pericardium, Brain

Animal Models for Tuberculosis or affiliated genes

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37MGI
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Publications for Tuberculosis

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52PubMed
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Articles related to Tuberculosis:

(show top 50)    (show all 6888)
idTitleAuthorsYear
1
Pulmonary hemorrhage complicating Goodpasture's disease in the course of pulmonary tuberculosis. (22826144)
2013
2
Infertility, in vitro fertilization and congenital tuberculosis. (23803676)
2013
3
Resistance to second-line drugs in multidrug-resistant tuberculosis. (23439097)
2013
4
Molecular Epidemiology of Mycobacterium tuberculosis Complex in Singapore, 2006-2012. (24367667)
2013
5
Incidence of paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome and impact on patient outcome. (24367678)
2013
6
A cross-sectional study of sputum handling by and supervision of patients with pulmonary tuberculosis treated at home in China. (23337789)
2012
7
Cytokine-secreting activity of blood eosinophils in pulmonary tuberculosis. (22866301)
2012
8
Pulmonary tuberculosis associated retinal vasculitis presenting as xanthopsia. (21428751)
2011
9
Isolated porta hepatis lymphadenitis as a presenting feature of tuberculosis. (21841597)
2011
10
Polymorphism in the p2x7 gene increases susceptibility to extrapulmonary tuberculosis in Turkish children. (20661107)
2010
11
Variants in toll-like receptors 2 and 9 influence susceptibility to pulmonary tuberculosis in Caucasians, African-Americans, and West Africans. (19771452)
2010
12
Ultrasonography for diagnosis of abdominal tuberculosis in HIV infected people. (20693594)
2010
13
Primary nodular hepatic tuberculosis mimicking hepatic neoplasia in an immunocompetent host. (20140362)
2009
14
Monocyte chemotactic protein-1 gene polymorphism and monocyte chemotactic protein-1 expression in Chongqing Han children with tuberculosis]. (19573434)
2009
15
Genetic polymorphism of glutathione-S-transferase M1 and T1: a systematic review in Chinese population and a pilot study in smear-positive pulmonary tuberculosis cases of Jilin province]. (19799150)
2009
16
Risk factors and mortality associated with default from multidrug-resistant tuberculosis treatment. (18462099)
2008
17
Simultaneous occurrence of pulmonary tuberculosis and carcinomatous lymphangitis. (17486260)
2007
18
Tumor necrosis factor and tuberculosis. (17502865)
2007
19
Disseminated histoplasmosis and tuberculosis in a patient with HIV infection. (17594164)
2007
20
Tuberculous uveitis: distribution of Mycobacterium tuberculosis in the retinal pigment epithelium. (17159041)
2006
21
Inducible costimulator: a modulator of IFN-gamma production in human tuberculosis. (16670305)
2006
22
Sphingosine kinase 1 (SK1) is recruited to nascent phagosomes in human macrophages: inhibition of SK1 translocation by Mycobacterium tuberculosis. (15749892)
2005
23
Limited good and limited vision: multidrug-resistant tuberculosis and global health policy. (15896895)
2005
24
Morphometric analysis of Th(1) and Th(2) cytokine expression in human pulmonary tuberculosis. (15525561)
2004
25
Clinical characteristics of 110 miliary tuberculosis patients from a low HIV prevalence country. (15141744)
2004
26
The regulatory effect of the supernatant of human airway epithelial cells transfected with DNA vaccine of 30-kilodalton major secretory protein of mycobacterium tuberculosis on the Th1/Th2 balance in mite allergic asthmatics]. (14505522)
2003
27
Allelic distribution of human leukocyte antigen in Iranian patients with pulmonary tuberculosis. (12507823)
2003
28
Pseudo tumoral laryngeal tuberculosis. (12554919)
2003
29
Abdominal tuberculosis mimicking Crohn's disease: a difficult diagnosis. Report of a case. (12032437)
2002
30
Purification and biochemical characterization of Mycobacterium tuberculosis SuhB, an inositol monophosphatase involved in inositol biosynthesis. (11914086)
2002
31
Current concepts on pathogenesis of renal tuberculosis. (11768007)
2001
32
A rare complication of miliary tuberculosis: intestinal perforation. (11301949)
2001
33
Clinical aspects of miliary tuberculosis in Saudi adults. (10751072)
2000
34
Use of systemic immunomodulator xymedone in distructive pulmonary tuberculosis]. (10900981)
2000
35
Renal tuberculosis in children. (10902487)
2000
36
Live antigen carriers as tools for improved anti-tuberculosis vaccines. (10076914)
1999
37
Diagnosis of extrapulmonary tuberculosis by a commercial polymerase chain reaction kit. (9871931)
1998
38
Mycobacterium tuberculosis antigen, interleukin 2 and interleukin 2 inhibitor in patients with rheumatoid arthritis. (8575840)
1995
39
Intestinal perforation due to Mycobacterium tuberculosis in HIV-infected individuals: report of two cases. (8470647)
1993
40
Mycobacterium tuberculosis expresses two chaperonin-60 homologs. (7681982)
1993
41
Bacteriostatic and bactericidal activity of antituberculosis drugs against Mycobacterium tuberculosis, Mycobacterium avium-Mycobacterium intracellulare complex and Mycobacterium kansasii in different growth phases. (1406364)
1992
42
Systemic lupus erythematosus and miliary tuberculosis in a prepubertal girl--a case report. (2152059)
1990
43
Six months' chemotherapy for lymph node tuberculosis. (2616826)
1989
44
Gallstone disease and lithogenicity of bile in intestinal tuberculosis. (7129559)
1982
45
Experiences in the diagnosis and treatment of renal tuberculosis. (13959600)
1962
46
An unusual arteriogram of renal tuberculosis. (14419285)
1960
47
Partial nephrectomy in renal tuberculosis. (13569735)
1957
48
Cyanoacetylhydrazine in therapy of urogenital tuberculosis; test of use as sole medication]. (14395579)
1955
49
Changes in the pulse rate of intestinal tuberculosis patients by abdominal pressure. (13164003)
1954
50
Prognosis of renal tuberculosis treated by nephrectomy. (14909354)
1952

Variations for Tuberculosis

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1 National Center for Biotechnology Information (Clinvar)
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Clinvar genetic disease variations for Tuberculosis:

1
id Gene Name Type Significance SNP ID Assembly Location
1CCL2NG_012123.1: g.2493A> Gsingle nucleotide variantPathogenic, risk factorrs1024611GRCh37Chr 17, 32579788: 32579788

Expression for genes affiliated with Tuberculosis

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Tuberculosis

Search GEO for disease gene expression data for Tuberculosis.

Pathways for genes affiliated with Tuberculosis

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50PathCards, 60Thomson Reuters, 38NCBI BioSystems Database, 30KEGG, 5Cell Signaling Technology, 53QIAGEN, 54R&D Systems, 55Reactome
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Pathways related to Tuberculosis according to GeneCards/GeneDecks:

(show all 48)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3IL12RB1, IFNG
210.3IL18, IFNG
310.3IL18, TNF
410.3TNF, VDR
5
Show member pathways
10.2IFNGR1, IFNG, IL18
6
Show member pathways
Development Thrombopoetin signaling via JAK STAT pathway60
10.2CISH, IFNG, IL4
710.2IL10, IL4, CISH
8
Show member pathways
10.2TNF, IFNGR1, IFNG
910.2IFNG, IFNGR1, TNF
10
Show member pathways
10.2TNF, IFNGR1, IFNG
1110.2IL10, IL4, IFNG
12
Show member pathways
10.2TNF, IFNG, IL10
13
Show member pathways
IL-9 Signaling Pathway38
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway38
Immune response IL 9 signaling pathway60
10.2TNF, CISH, IL4
14
Show member pathways
Calcium signaling in the CD4+ TCR pathway38
10.2TNF, IFNG, IL4
1510.2IL4, IFNG, TNF
1610.2IFNG, TNF, VDR
1710.2TLR2, TNF, IL18
1810.2TNF, TIRAP, IL10
19
Show member pathways
10.2TLR2, TNF, TIRAP
20
Show member pathways
10.1CISH, IFNGR1, IFNG, IL18
2110.1IFNG, IFNGR1, TNF, TLR2
22
Show member pathways
Immune response CD16 signaling in NK cells60
10.1TNF, IFNGR1, IFNG, IL4
2310.1TLR2, TNF, IFNG, IL10
24
Show member pathways
Immune response MIF in innate immunity response60
10.1IFNG, IFNGR1, TIRAP, TNF
25
Show member pathways
10.1TLR2, IFNG, IL4, IL12RB1
2610.1IL10, IL18, IFNG, TNF
27
Show member pathways
Immune response IL 12 induced IFN gamma production60
10.1IL12RB1, IL18, IL4, IFNG
2810.1TNF, IFNG, IL4, IL10
29
Show member pathways
BCR signaling pathway38
TCR Signaling Pathway38
10.1IL10, IL4, IFNG, TNF
3010.1TLR2, TNF, IFNG, IL18
3110.1TLR2, TNF, IFNG, IL18
32
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways60
Immune response IL 1 signaling pathway60
10.1TLR2, TNF, TIRAP, IL18
33
Show member pathways
10.0IL4, IFNG, IFNGR1, TNF, TLR2
3410.0TLR2, TNF, IFNG, IL18, IL10
35
Show member pathways
IL23-mediated signaling events38
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling38
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
10.0TNF, IFNG, IL18, IL10, IL12RB1
3610.0TNF, IFNG, IL4, IL18, IL10
37
Show member pathways
10.0IL12RB1, IL10, IL18, IL4, TNF
38
Show member pathways
Type III interferon signaling38
10.0CISH, IFNGR1, IFNG, IL4, IL10, IL12RB1
39
Show member pathways
Toll-like receptor signaling pathway38
Regulation of toll-like receptor signaling pathway38
9.9TLR2, TNF, TIRAP, IFNGR1, IFNG, IL10
40
Show member pathways
9.9TLR2, TNF, IFNGR1, IFNG, IL4, IL18
41
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
9.9TLR2, TNF, TIRAP, IFNGR1, IFNG, IL4
42
Show member pathways
IL27-mediated signaling events38
9.8TLR2, TNF, IFNGR1, IFNG, IL18, IL10
43
Show member pathways
9.8TNF, IFNGR1, IFNG, IL4, IL18, IL10
44
Show member pathways
9.8TNF, IFNGR1, IFNG, IL4, IL18, IL10
45
Show member pathways
9.8TLR2, TNF, TIRAP, IL4, IL18, IL10
46
Show member pathways
9.8TNF, CISH, IFNGR1, IFNG, IL4, IL18
479.7VDR, TLR2, TNF, TIRAP, IFNGR1, IFNG
48
Show member pathways
9.7IL12RB1, TLR2, TNF, IRGM, IFNGR1, IFNG

Compounds for genes affiliated with Tuberculosis

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45Novoseek, 11DrugBank, 61Tocris Bioscience, 29IUPHAR, 51PharmGKB, 24HMDB
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Compounds related to Tuberculosis according to GeneCards/GeneDecks:

(show top 50)    (show all 121)
idCompoundScoreTop Affiliating Genes
1interferon gamma4510.5TNF, IL4, IFNG, IL10
2betaseron4510.5IL10, IL4, IFNG
3amphotericin b4510.5TLR2, ADA, IFNG, IL4
4natalizumab45 1111.5IL10, TNF, IFNG, IL18
5tuberculin4510.4IFNG, IL18, MBL2, IL10, ADA
6indoleamine4510.4TNF, IL18, IL10, IFNG
7imiquimod45 61 29 1113.4TLR2, TNF, IL18, IL10, IFNG
8rolipram45 61 2912.4IL10, ADA, TNF, IL4, IFNG
9okt34510.4TNF, IFNG, IL10, IL4
10gm-csf45 2911.4IL10, IL18, TNF, IL4, IFNG
11con a4510.4IL4, IL18, IL10, MBL2, IFNG
12poly(i-c)4510.4TNF, IFNG, TLR2, IL18, IL4
132,5-oligoadenylate4510.4IL10, IFNG, TNF, ADA
14infliximab45 51 1112.4IL10, IL18, IL4, IFNG, TNF
15lipoteichoic acid4510.4IL18, IL10, TNF, TLR2, MBL2
16tarc4510.4IFNG, IL10, IL18, IL4, TNF
17ccl345 2911.4IL10, IFNG, TNF, TLR2, IL18
18pentoxifylline45 1111.4IL18, IL4, IFNG, TNF, IL10
19etanercept45 51 1112.4TNF, IFNG, IL18, IL10
20il-124510.3IL12RB1, IL10, IL18, IL4, IFNG, TNF
21polyinosinic-polycytidylic acid4510.3IFNG, IL4, TNF, TLR2, IL10, IL18
22mycophenolate mofetil45 51 1112.3IL18, TNF, IFNG, IL10
23ribavirin45 51 1112.3MBL2, IL18, IFNG, ADA, IL10, IL4
24polymyxin b4510.3TLR2, MBL2, TNF, IL10, IL4, IFNG
25alpha-galactosylceramide4510.3IL10, IL4, IFNG
26simvastatin45 51 61 29 24 1115.3IL10, IL18, IFNG, TNF, TLR2, IL4
27prednisolone45 29 1112.3MBL2, TNF, IFNG, IL18, IL10
28anti-fungal4510.3TLR2, MBL2, IFNG, GNLY
29peptidoglycan45 2911.2IL10, TLR2, TNF, MBL2
30il 104510.2IL18, IL10, IL4, IFNG, TNF, TLR2
31calcitriol45 61 24 1113.2IFNG, IL4, TLR2, IL10, VDR, TNF
32neopterin4510.2IL4, ADA, TNF, IL18, IL10, MBL2
33ivig4510.2IFNG, IL10, TNF, IL4
34endotoxin4510.2TLR2, IL10, TNF, IL18, IFNG
35tacrolimus45 51 1112.2IFNG, IL10, IL18, IL4, TLR2, VDR
36ifn-alpha4510.2IL10, IL18, IFNG, CISH
37histamine45 29 2412.2IL18, IL4, IFNG, ADA, TNF, TLR2
38sb 20358045 6111.2IL10, IL4, TLR2, IL18, IFNG, TNF
39pge24510.1IL18, TNF, IFNG, IL10, TLR2, VDR
40cyclosporin a45 29 6112.1VDR, IFNG, IL10, ADA, TNF, IL4
41ionomycin4510.1TLR2, GNLY, TNF, IL18, IL4, IFNG
42allergens4510.1IFNG, IL18, IL10, IL4
43rantes4510.1TNF, GNLY, TLR2, IFNG, IL18, IL10
44cycloheximide4510.1TNF, IL18, VDR, IL10, IFNG, IL4
45nitric oxide45 24 1112.1CISH, IFNG, MBL2, SLC11A1, IL18, TLR2
46vegf4510.0IFNG, ADA, IL10, MBL2, IL18, TNF
47dexamethasone45 51 29 1112.9IL4, IFNG, ADA, CISH, TNF, TLR2
4815-deoxy-delta-12,14-prostaglandin j2459.8IL10, IFNG, IL4, TNF
49arginine459.8GNLY, VDR, TLR2, ADA, IFNG, IL4
50tyrosine459.5TIRAP, IL4, CISH, IFNGR1, IL12RB1, TLR2

GO Terms for genes affiliated with Tuberculosis

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16Gene Ontology
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Cellular components related to Tuberculosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:00998610.1MBL2, ADA, TNF, TLR2
2phagocytic cupGO:00189110.0TNF, IRGM
3external side of plasma membraneGO:0098979.9IL12RB1, TLR2, TNF, ADA, IFNG, IL4
4extracellular spaceGO:0056159.6GNLY, TNF, ADA, IFNG, IL4, IL18

Biological processes related to Tuberculosis according to GeneCards/GeneDecks:

(show top 50)    (show all 51)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of vitamin D biosynthetic processGO:06055710.7IFNG, TNF
2positive regulation of calcidiol 1-monooxygenase activityGO:06055910.7TNF, IFNG
3regulation of isotype switchingGO:04519110.7IL4, IL10
4cellular response to bacterial lipopeptideGO:07122110.7TLR2, TIRAP
5receptor biosynthetic processGO:03280010.7TNF, IL10
6positive regulation of interleukin-18 productionGO:03274110.6TLR2, TNF
7positive regulation of isotype switching to IgG isotypesGO:04830410.6IFNG, IL4
8negative regulation of cytokine secretion involved in immune responseGO:00274010.6IL10, TNF
9defense response to protozoanGO:04283210.6SLC11A1, IL4, IFNG
10positive regulation of MHC class II biosynthetic processGO:04534810.6IL10, IL4, IFNG
11type 2 immune responseGO:04209210.6IL10, IL18, IL4
12negative regulation of interleukin-17 productionGO:03270010.6IFNG, TLR2
13positive regulation of T-helper 1 type immune responseGO:00282710.6IL12RB1, SLC11A1
14positive regulation of interleukin-6 biosynthetic processGO:04541010.6IFNG, TIRAP
15protein import into nucleus, translocationGO:00006010.6SLC11A1, IFNG, TNF
16positive regulation of chemokine (C-X-C motif) ligand 2 productionGO:200034310.6TNF, TIRAP
17positive regulation of chemokine biosynthetic processGO:04508010.6TNF, IFNG, IL4
18cellular response to lipoteichoic acidGO:07122310.6TIRAP, TLR2
19positive regulation of interleukin-12 productionGO:03273510.6TLR2, TIRAP, IFNG
20positive regulation of activated T cell proliferationGO:04210410.6IL12RB1, IL18, IL4
21positive regulation of NF-kappaB import into nucleusGO:04234610.6TLR2, TNF, IL18
22positive regulation of cytokine secretionGO:05071510.6IL10, TNF, TLR2
23positive regulation of nitric oxide biosynthetic processGO:04542910.6TLR2, TNF, IFNG
24negative regulation of nitric oxide biosynthetic processGO:04501910.6IL4, IL10
25negative regulation of interleukin-12 productionGO:03269510.6IL10, TLR2
26lipopolysaccharide-mediated signaling pathwayGO:03166310.6IL18, TNF, TLR2
27positive regulation of tumor necrosis factor productionGO:03276010.6TLR2, TIRAP, IFNG
28positive regulation of B cell proliferationGO:03089010.6TIRAP, ADA, IL4
29positive regulation of membrane protein ectodomain proteolysisGO:05104410.6IFNG, TNF
30regulation of interferon-gamma-mediated signaling pathwayGO:06033410.5IFNG, IFNGR1
31positive regulation of interferon-gamma productionGO:03272910.5TNF, IL18, IL12RB1, SLC11A1
32positive regulation of chemokine productionGO:03272210.5TLR2, TNF
33embryonic digestive tract developmentGO:04856610.5ADA, TNF
34positive regulation of sequence-specific DNA binding transcription factor activityGO:05109110.5IL10, IL4, TNF
35defense response to Gram-positive bacteriumGO:05083010.5MBL2, TIRAP, TNF, TLR2
36response to virusGO:00961510.5IFNG, IFNGR1, TNF
37positive regulation of interleukin-10 productionGO:03273310.5TLR2, IL4
38positive regulation of cytokine productionGO:00181910.4TNF, SLC11A1
39defense response to bacteriumGO:04274210.4GNLY, IFNG, IL10, MBL2, SLC11A1
40response to drugGO:04249310.4IL10, IL4, IFNG, TNF
41positive regulation of osteoclast differentiationGO:04567210.4IFNG, TNF
42positive regulation of NF-kappaB transcription factor activityGO:05109210.4TLR2, TNF, TIRAP
43negative regulation of growth of symbiont in hostGO:04413010.3MBL2, IL10, IFNG, TIRAP, TNF, TLR2
44positive regulation of interleukin-8 productionGO:03275710.3TLR2, TIRAP
45inflammatory responseGO:00695410.3TLR2, TNF, TIRAP, IRGM, IL18, IL10
46positive regulation of gene expressionGO:01062810.3SLC11A1, IL18, VDR
47positive regulation of transcription from RNA polymerase II promoterGO:04594410.2VDR, TLR2, TNF, IFNG, IL4, IL10
48cell surface receptor signaling pathwayGO:00716610.2IFNG, TIRAP, INHA
49negative regulation of interleukin-6 productionGO:03271510.2IL10, TNF
50response to hypoxiaGO:0016669.9ADA, TNF, TLR2

Molecular functions related to Tuberculosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:00808310.2IL10, IL4, INHA
2cytokine activityGO:0051259.6IL10, IL18, IL4, IFNG, TNF, INHA

Products for genes affiliated with Tuberculosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Tuberculosis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet