MCID: TBR011
MIFTS: 54

Tuberculous Meningitis

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Tuberculous Meningitis

MalaCards integrated aliases for Tuberculous Meningitis:

Name: Tuberculous Meningitis 49 55
Tubercular Meningitis 49 55
Tuberculosis, Meningeal 69
Meningitis Tuberculous 51
Tb Meningitis 49
Tbm 55

Classifications:



External Ids:

Orphanet 55 ORPHA499004
ICD10 32 A17.0
UMLS 69 C0041318

Summaries for Tuberculous Meningitis

MalaCards based summary : Tuberculous Meningitis, also known as tubercular meningitis, is related to extrapulmonary tuberculosis and mycobacterium tuberculosis 1. An important gene associated with Tuberculous Meningitis is ADA (Adenosine Deaminase), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Dexamethasone and Dexamethasone acetate have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and t cells, and related phenotypes are homeostasis/metabolism and cardiovascular system

Wikipedia : 72 Tuberculous meningitis is also known as TB meningitis or tubercular meningitis. Tuberculous meningitis... more...

Related Diseases for Tuberculous Meningitis

Diseases related to Tuberculous Meningitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 215)
# Related Disease Score Top Affiliating Genes
1 extrapulmonary tuberculosis 32.5 ADA CCL2 TLR2
2 mycobacterium tuberculosis 1 31.0 ADA NAT2 TLR2 TNF
3 meningitis 30.9 ADA CCL2 CXCL8 LYZ MMP9 TLR2
4 bacterial meningitis 30.4 CXCL8 MMP9 TLR2 TNF
5 miliary tuberculosis 30.3 ADA ENO2
6 endocarditis 30.0 CXCL8 TLR2 TNF
7 leishmaniasis 29.9 TGFB1 TLR2 TNF
8 visceral leishmaniasis 29.9 ADA CXCL8 TLR2 TNF
9 pulmonary tuberculosis 29.1 ADA CCL3 NAT2 TLR2 TNF
10 tracheobronchomalacia 11.8
11 tuberculous peritonitis 11.1
12 mycobacterium chelonae 10.6 CXCL8 TLR2
13 beryllium disease 10.5 TGFB1 TNF
14 tungiasis 10.5 CXCL8 TNF
15 mycobacterium kansasii 10.5 CXCL8 TLR2
16 clonorchiasis 10.4 CXCL8 TGFB1 TNF
17 vibratory urticaria 10.4 CXCL8 MMP9
18 leukoregulin 10.4 CXCL8 TGFB1
19 haemophilus influenzae 10.4 CXCL8 TLR2 TNF
20 mycobacterium abscessus 10.4 CXCL8 TLR2 TNF
21 trench fever 10.4 TLR2 TNF
22 prostatitis 10.4 CXCL8 TGFB1 TNF
23 middle ear disease 10.4 CXCL8 TLR2 TNF
24 streptococcal toxic-shock syndrome 10.4 CXCL8 TNF
25 transverse myelitis 10.4 CXCL8 MMP9 TNF
26 bacterial vaginosis 10.4 CXCL8 TLR2 TNF
27 diabetic foot ulcers 10.4 MMP9 TGFB1
28 hydrocephalus 10.4
29 primary bacterial infectious disease 10.4 ADA TLR2 TNF
30 acute transverse myelitis 10.4 CXCL8 MMP9
31 rheumatic heart disease 10.4 TGFB1 TLR2 TNF
32 bronchiolitis obliterans 10.4 CXCL8 MMP9 TNF
33 carotid stenosis 10.4 CXCL8 MMP9 TNF
34 spinal cord injury 10.4 CXCL8 MMP9 TNF
35 chronic fatigue syndrome 10.4 CXCL8 TGFB1 TNF
36 gingivitis 10.4 CXCL8 MMP9 TNF
37 herpes simplex virus keratitis 10.4 CCL2 CXCL8
38 chlamydia 10.4 CXCL8 TLR2 TNF
39 otitis media 10.4 CXCL8 TLR2 TNF
40 critical limb ischemia 10.4 TNF VEGFA
41 allergic contact dermatitis 10.3 CXCL8 NAT2 TNF
42 alcoholic liver cirrhosis 10.3 CXCL8 NAT2 TNF
43 cerebritis 10.3
44 viral meningitis 10.3 ADA CCL2 CXCL8
45 viral encephalitis 10.3 CCL2 CXCL8 TNF
46 pyelonephritis 10.3 CCL2 CXCL8 TNF
47 congenital granular cell tumor 10.3 ENO2 LYZ
48 bronchial disease 10.3 ALOX5 CXCL8 TNF
49 angiokeratoma circumscriptum 10.3 MMP9 VEGFA
50 severe acute respiratory syndrome 10.3 CCL2 CXCL8 TNF

Graphical network of the top 20 diseases related to Tuberculous Meningitis:



Diseases related to Tuberculous Meningitis

Symptoms & Phenotypes for Tuberculous Meningitis

MGI Mouse Phenotypes related to Tuberculous Meningitis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.14 GGT1 LYZ ADA MMP9 NAT2 ALOX5
2 cardiovascular system MP:0005385 10.13 TGFB1 LYZ ADA MMP9 ALOX5 NPPA
3 hematopoietic system MP:0005397 10.13 TGFB1 LYZ ADA MMP9 ALOX5 NPPA
4 immune system MP:0005387 10.11 TGFB1 LTA4H LYZ ADA MMP9 ALOX5
5 digestive/alimentary MP:0005381 10 TGFB1 LYZ ADA MMP9 VEGFA TLR2
6 muscle MP:0005369 9.87 TGFB1 ADA MMP9 NPPA VEGFA TLR2
7 renal/urinary system MP:0005367 9.76 LYZ ADA MMP9 NPPA GGT1 TGFB1
8 neoplasm MP:0002006 9.73 TGFB1 LYZ MMP9 VEGFA TLR2 TNF
9 respiratory system MP:0005388 9.56 TGFB1 LYZ ADA MMP9 ENO2 TLR2
10 skeleton MP:0005390 9.28 TGFB1 LYZ ADA MMP9 ALOX5 GGT1

Drugs & Therapeutics for Tuberculous Meningitis

Drugs for Tuberculous Meningitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 75)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3 50-02-2 5743
2 Dexamethasone acetate Phase 4,Phase 2,Phase 3 1177-87-3
3 glucocorticoids Phase 4,Phase 2,Phase 3
4
protease inhibitors Phase 4,Phase 2,Phase 3
5 Gastrointestinal Agents Phase 4,Phase 2,Phase 3
6 HIV Protease Inhibitors Phase 4,Phase 2,Phase 3
7 Hormone Antagonists Phase 4,Phase 2,Phase 3
8 Hormones Phase 4,Phase 2,Phase 3
9 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3
10 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3
11 Antiemetics Phase 4,Phase 2,Phase 3
12 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3
13 Antineoplastic Agents, Hormonal Phase 4,Phase 2,Phase 3
14 BB 1101 Phase 4,Phase 2,Phase 3
15 Autonomic Agents Phase 4,Phase 2,Phase 3
16
Rifampin Approved Phase 2, Phase 3,Phase 1 13292-46-1 5381226 5458213
17
Pyrazinamide Approved, Investigational Phase 2, Phase 3,Phase 1 98-96-4 1046
18
Ethambutol Approved Phase 2, Phase 3,Phase 1 74-55-5 14052 3279
19
Pyridoxine Approved, Investigational, Nutraceutical, Vet_approved Phase 2, Phase 3 65-23-6 1054
20
Pyridoxal Approved, Nutraceutical Phase 2, Phase 3 66-72-8 1050
21
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2, Phase 3 59-30-3 6037
22 Cytochrome P-450 CYP3A Inducers Phase 2, Phase 3,Phase 1
23 Nucleic Acid Synthesis Inhibitors Phase 2, Phase 3,Phase 1
24 Anti-Infective Agents Phase 2, Phase 3,Phase 1
25 Micronutrients Phase 2, Phase 3
26 Trace Elements Phase 2, Phase 3
27 Vitamin B 6 Phase 2, Phase 3
28 Vitamin B Complex Phase 2, Phase 3
29 Vitamins Phase 2, Phase 3
30 Anti-Bacterial Agents Phase 2, Phase 3,Phase 1
31 Antibiotics, Antitubercular Phase 2, Phase 3,Phase 1
32 Antitubercular Agents Phase 2, Phase 3, Phase 1
33 Liver Extracts Phase 3
34 Folate Nutraceutical Phase 2, Phase 3
35 Vitamin B9 Nutraceutical Phase 2, Phase 3
36
Aspirin Approved, Vet_approved Phase 2 50-78-2 2244
37
Estradiol Approved, Investigational, Vet_approved Phase 2 50-28-2 5757
38
Norgestimate Approved, Investigational Phase 2 35189-28-7 6540478
39
Moxifloxacin Approved, Investigational Phase 2 151096-09-2, 354812-41-2 152946
40
Ethinyl Estradiol Approved Phase 2 57-63-6 5991
41
Isoniazid Approved, Investigational Phase 1, Phase 2 54-85-3 3767
42
Ofloxacin Approved Phase 1, Phase 2 82419-36-1 4583
43
Levofloxacin Approved, Investigational Phase 1, Phase 2 100986-85-4 149096
44
BCG vaccine Investigational Phase 2
45 Cytochrome P-450 Enzyme Inhibitors Phase 1, Phase 2
46 Estradiol valerate Phase 2 979-32-8
47 Analgesics Phase 2
48 Fibrinolytic Agents Phase 2
49 Adjuvants, Immunologic Phase 2
50 Topoisomerase Inhibitors Phase 2,Phase 1

Interventional clinical trials:

(show all 15)

# Name Status NCT ID Phase Drugs
1 The Relationships Between Gene Polymorphisms of LTA4H and Dexamethasone Treatment for Tuberculous Meningitis Not yet recruiting NCT02588196 Phase 4 Dexamethasone acetate
2 High-dose Rifampicin for the Treatment of Tuberculous Meningitis: a Dose-finding Study Completed NCT02169882 Phase 2, Phase 3 Placebo;Rifampicin;Other TB drugs;Adjuvant dexamethasone
3 Treatment Duration for Abdominal Tuberculosis Completed NCT01124929 Phase 3 RNTCP Category I treatment for 6 months;RNTCP Category I treatment for 9months
4 Adjunctive Corticosteroids for Tuberculous Meningitis in HIV-infected Adults (The ACT HIV Trial) Recruiting NCT03092817 Phase 3 Dexamethasone
5 Leukotriene A4 Hydrolase Stratified Trial of Adjunctive Corticosteroids for HIV-uninfected Adults With Tuberculous Meningitis Not yet recruiting NCT03100786 Phase 3 Dexamethasone
6 A Pilot Study of Adjunctive Aspirin for the Treatment of HIV Negative Adults With Tuberculous Meningitis Completed NCT02237365 Phase 2 81mg aspirin;1000mg aspirin;Placebo
7 Rifampicin Explorative PK Study for Tuberculous Meningitis Comparing Oral and Intravenous Preparation Completed NCT01802502 Phase 2 Rifampicin intravenous;Oral rifampicin
8 Intensified Treatment Regimens for TB Meningitis: PK, PD and Tolerability Study Completed NCT01158755 Phase 2 Moxifloxacin
9 Safety and Immunogenicity of MVA85A Prime and Bacille Calmette-Guerin Boost Vaccination Completed NCT01650389 Phase 2
10 Optimizing Treatment to Improve TBM Outcomes in Children Recruiting NCT02958709 Phase 1, Phase 2 High-dose: RIF, INH, PZA, EMB;High dose: RIF, INH, PZA, LEVO;Standard of care: RIF, INH, PZA, EMB
11 Study of the Safety and Immunogenicity of Bacille Calmette Guerin (BCG) Vaccine Completed NCT00654316 Phase 1
12 Immediate Versus Deferred Antiretroviral Therapy for HIV-Associated Tuberculous Meningitis Unknown status NCT00433719 Combivir and efavirenz
13 Diagnosis of Tuberculous Meningitis by ESAT-6 in CSF Completed NCT01371916
14 Study Of The Long Term Outcome Of Tuberculous Meningitis In Vietnamese Adults Treated With Adjunctive Dexamethasone Completed NCT01317654
15 Driving Reduced AIDS-associated Meningo-encephalitis Mortality Recruiting NCT03226379

Search NIH Clinical Center for Tuberculous Meningitis

Genetic Tests for Tuberculous Meningitis

Anatomical Context for Tuberculous Meningitis

MalaCards organs/tissues related to Tuberculous Meningitis:

38
Testes, Brain, T Cells, Spinal Cord, Liver, Endothelial, B Cells

Publications for Tuberculous Meningitis

Articles related to Tuberculous Meningitis:

(show top 50) (show all 704)
# Title Authors Year
1
Diffuse Leptomeningeal Glioneural Tumour Simulating Tuberculous Meningitis in a 13-Year-Old Girl. ( 29301133 )
2018
2
Microbiological diagnosis of adult tuberculous meningitis in a ten-year cohort in Indonesia. ( 29444749 )
2018
3
Isoniazid and rifampicin heteroresistant Mycobacterium tuberculosis isolated from tuberculous meningitis patients in India. ( 29332649 )
2018
4
Is drug-induced hepatitis related to the severity of tuberculous meningitis? ( 29438557 )
2018
5
Scrub Typhus Meningitis Versus Acute Bacterial Meningitis and Tuberculous Meningitis. ( 29396931 )
2018
6
Absence of cerebrospinal fluid pleocytosis in tuberculous meningitis is a common occurrence in HIV co-infection and a predictor of poor outcomes. ( 29391245 )
2018
7
Development of a clinical prediction rule for tuberculous meningitis in adults in Lima, Peru. ( 29446860 )
2018
8
Comparison of Scrub Typhus Meningitis with Acute Bacterial Meningitis and Tuberculous Meningitis. ( 29396933 )
2018
9
Could omics unlock the secret of surviving tuberculous meningitis? ( 29398390 )
2018
10
Cerebral tryptophan metabolism and outcome of tuberculous meningitis: an observational cohort study. ( 29395996 )
2018
11
Vitamin D deficiency in patients with tuberculous meningitis and its relationship with treatment outcome. ( 29297432 )
2018
12
Tuberculous meningitis is associated with higher cerebrospinal HIV-1 viral loads compared to other HIV-1-associated meningitides. ( 29394269 )
2018
13
Mycobacterium marinum Infection in Zebrafish and Microglia Imitates the Early Stage of Tuberculous Meningitis. ( 29352446 )
2018
14
Diagnosis of tuberculous meningitis with invasive pulmonary sampling. ( 29303733 )
2018
15
Correction: optic disc swelling in a patient with tuberculous meningitis: a diagnostic challenge. ( 29348273 )
2018
16
Clinical presentations and outcomes of the children with tuberculous meningitis: An experience at a tertiary care hospital. ( 29371710 )
2018
17
Rapid Development of Intracranial Aneurysm Associated with Tuberculous Meningitis. ( 29391085 )
2017
18
Neurosyphilis with Concomitant Cryptococcal and Tuberculous Meningitis in a Patient with AIDS: Report of a Unique Case. ( 28928997 )
2017
19
A study of neuroendocrine dysfunction in patients of tuberculous meningitis. ( 28716240 )
2017
20
Spotted fever rickettsiae and tuberculous meningitis dual infection presenting as acute encephalitis syndrome: A fatal case report. ( 28748844 )
2017
21
Performance of nested RT-PCR on CSF for tuberculous meningitis diagnosis in HIV-infected patients. ( 28911358 )
2017
22
Cerebrospinal Fluid Leukotriene B4 and Soluble Tumor Necrosis Factor Receptor II Levels and Treatment Outcome in Tuberculous Meningitis. ( 28859433 )
2017
23
Unusual case of tuberculous meningitis with discordant ventricular and lumbar cerebrospinal fluid; lessons in the era of world-wide migration. ( 28805285 )
2017
24
Tuberculous Meningitis in Children and Adults: New Insights for an Ancient Foe. ( 28932979 )
2017
25
Cytokines do play a role in pathogenesis of tuberculous meningitis: A prospective study from a tertiary care center in India. ( 28716226 )
2017
26
Correlation of Lactate Concentration in Peripheral Plasma and Cerebrospinal Fluid with Glasgow Outcome Scale for Patients with Tuberculous Meningitis Complicated by Acute Hydrocephalus Treated with Fluid Diversions. ( 29248780 )
2017
27
Contribution of brain CT in the diagnosis of tuberculous meningitis: a case report from Djibouti. ( 28721934 )
2017
28
Surgical Management of Syringomyelia Associated with Spinal Adhesive Arachnoiditis, a Late Complication of Tuberculous Meningitis: A Case Report. ( 28512616 )
2017
29
Tuberculous meningitis and hydrocephalus in Filippino de' Medici. ( 28504108 )
2017
30
Tuberculous meningitis. ( 28884751 )
2017
31
High-performance liquid chromatography with time-programmed fluorescence detection for the quantification of Levofloxacin in human plasma and cerebrospinal fluid in adults with tuberculous meningitis. ( 28756357 )
2017
32
Leukotriene A4 Hydrolase Genotype and HIV Infection Influence Intracerebral Inflammation and Survival From Tuberculous Meningitis. ( 28419368 )
2017
33
Predictors of adverse outcome in patients of tuberculous meningitis in a multi-centric study from India. ( 28941852 )
2017
34
Clinical Parameters, Routine Inflammatory Markers, and LTA4H Genotype as Predictors of Mortality Among 608 Patients With Tuberculous Meningitis in Indonesia. ( 28419315 )
2017
35
Diagnostic accuracy of Xpert MTB/RIF Ultra for tuberculous meningitis in HIV-infected adults: a prospective cohort study. ( 28919338 )
2017
36
Rare Clinical Presentation of Tuberculous Meningitis: A Case Report. ( 29386980 )
2017
37
Differential diagnosis of scrub typhus meningitis from tuberculous meningitis using clinical and laboratory features. ( 29078126 )
2017
38
Optic disc swelling in a patient with tuberculous meningitis: a diagnostic challenge. ( 28794092 )
2017
39
Diagnosis of tuberculous meningitis: Current scenario from a Tertiary Neurocare Centre in India. ( 28709486 )
2017
40
Identification of potential metabolic biomarkers of cerebrospinal fluids that differentiate tuberculous meningitis from other types of meningitis by a metabolomics study. ( 29245963 )
2017
41
Recent advances in the diagnosis and management of tuberculous meningitis. ( 27798497 )
2017
42
Xpert MTB/RIF Ultra: a gamechanger for tuberculous meningitis? ( 28919337 )
2017
43
A predictive score followed by nucleic acid amplification for adult tuberculous meningitis diagnosis in Southern Brazil. ( 28716254 )
2017
44
Rapid Accurate Identification of Tuberculous Meningitis Among South African Children Using a Novel Clinical Decision Tool. ( 28777205 )
2017
45
Comparison of clinical features and prognostic factors in HIV-negative adults with cryptococcal meningitis and tuberculous meningitis: a retrospective study. ( 28068915 )
2017
46
Cerebrospinal fluid matrix metalloproteinase 9 levels, blood-brain barrier permeability, and treatment outcome in tuberculous meningitis. ( 28704492 )
2017
47
The application of IS6110-baced loop-mediated isothermal amplification (LAMP) in the early diagnosis of tuberculous meningitis. ( 28915693 )
2017
48
Imaging Features of the Brain, Cerebral Vessels and Spine in Pediatric Tuberculous Meningitis with Associated Hydrocephalus. ( 27213261 )
2016
49
Predictors of Neurological Outcome of Tuberculous Meningitis in Childhood: A Prospective Cohort Study From a Developing Country. ( 27655469 )
2016
50
Significance of immune response to Mycobacterium tuberculosis culture filtrate protein antigens in cerebrospinal fluid of tuberculous meningitis patients: A search for diagnostic marker. ( 27454259 )
2016

Variations for Tuberculous Meningitis

Expression for Tuberculous Meningitis

Search GEO for disease gene expression data for Tuberculous Meningitis.

Pathways for Tuberculous Meningitis

Pathways related to Tuberculous Meningitis according to GeneCards Suite gene sharing:

(show all 40)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.97 ALOX5 CCL2 CCL3 CXCL8 LTA4H LYZ
2
Show member pathways
13.3 ALOX5 CCL2 CCL3 CXCL8 MMP9 TGFB1
3
Show member pathways
12.47 CXCL8 MMP9 TGFB1 TLR2 TNF VEGFA
4
Show member pathways
12.42 CCL2 CCL3 CXCL8 TGFB1 TLR2 TNF
5
Show member pathways
12.29 ALOX5 CCL2 GGT1 TNF
6
Show member pathways
12.28 CCL2 CXCL8 MMP9 TLR2 TNF
7 12.24 MMP9 TGFB1 TLR2 TNF VEGFA
8
Show member pathways
12.21 ALOX5 TGFB1 TLR2 TNF
9 12.11 MMP9 TGFB1 TLR2 TNF VEGFA
10 12.05 CCL2 MMP9 TNF VEGFA
11 11.89 CCL2 MMP9 TNF
12 11.88 CCL3 CXCL8 TGFB1
13
Show member pathways
11.87 TGFB1 TLR2 TNF
14 11.85 ENO2 NPPA VEGFA
15 11.85 CCL2 CXCL8 MMP9 TGFB1 TNF
16 11.84 CXCL8 TGFB1 TLR2 TNF
17 11.78 CCL2 MMP9 TGFB1
18 11.72 CCL2 CXCL8 TGFB1 TNF VEGFA
19 11.69 CXCL8 MMP9 VEGFA
20 11.64 TGFB1 TLR2 TNF
21 11.63 MMP9 TGFB1 VEGFA
22
Show member pathways
11.61 CXCL8 MMP9 TNF VEGFA
23 11.56 ALOX5 CCL2 CXCL8 MMP9 TGFB1 TNF
24 11.54 CXCL8 TLR2 TNF
25 11.5 CXCL8 TGFB1 VEGFA
26 11.47 CCL2 TLR2 TNF
27 11.43 CCL2 CCL3 CXCL8 MMP9 TGFB1 TNF
28 11.42 CCL2 CCL3 CXCL8 TNF
29 11.34 CCL2 CXCL8 TGFB1 TLR2 TNF
30
Show member pathways
11.33 CCL3 TGFB1 TNF
31 11.3 CCL2 CXCL8 MMP9
32 11.16 CCL2 CCL3 CXCL8 TNF
33 11.15 CCL2 MMP9 TLR2
34 11.12 ALOX5 GGT1 LTA4H
35 11.12 CCL2 CCL3 CXCL8 TGFB1 TLR2 TNF
36 10.96 CCL2 CCL3 CXCL8 TGFB1 TNF
37 10.91 MMP9 TGFB1
38 10.9 CCL2 CCL3 TNF
39 10.81 TGFB1 TNF
40 10.48 ALOX5 GGT1 LTA4H

GO Terms for Tuberculous Meningitis

Cellular components related to Tuberculous Meningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.73 ALOX5 CCL2 CCL3 CXCL8 LTA4H LYZ
2 cell surface GO:0009986 9.65 ADA TGFB1 TLR2 TNF VEGFA
3 extracellular space GO:0005615 9.44 ADA ALOX5 CCL2 CCL3 CXCL8 ENO2
4 tertiary granule lumen GO:1904724 9.33 LTA4H LYZ MMP9

Biological processes related to Tuberculous Meningitis according to GeneCards Suite gene sharing:

(show all 36)
# Name GO ID Score Top Affiliating Genes
1 neutrophil degranulation GO:0043312 9.99 ALOX5 LTA4H LYZ MMP9 TLR2
2 MAPK cascade GO:0000165 9.94 CCL2 CCL3 TGFB1 TNF
3 positive regulation of gene expression GO:0010628 9.92 CCL3 TGFB1 TLR2 TNF VEGFA
4 negative regulation of gene expression GO:0010629 9.88 CCL3 TGFB1 TNF VEGFA
5 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.86 CCL2 CCL3 TGFB1 TNF
6 positive regulation of cell migration GO:0030335 9.85 CCL3 MMP9 TGFB1 VEGFA
7 defense response to Gram-positive bacterium GO:0050830 9.83 LYZ TLR2 TNF
8 positive regulation of protein phosphorylation GO:0001934 9.81 MMP9 TGFB1 TNF VEGFA
9 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.8 TGFB1 TNF VEGFA
10 regulation of receptor activity GO:0010469 9.8 CCL2 CCL3 CXCL8 NPPA TGFB1 TNF
11 cellular response to interleukin-1 GO:0071347 9.79 CCL2 CCL3 CXCL8
12 chemokine-mediated signaling pathway GO:0070098 9.78 CCL2 CCL3 CXCL8
13 response to hypoxia GO:0001666 9.77 ADA NPPA TGFB1 TLR2 VEGFA
14 neutrophil chemotaxis GO:0030593 9.75 CCL2 CCL3 CXCL8
15 positive regulation of MAP kinase activity GO:0043406 9.74 TGFB1 TNF VEGFA
16 cellular response to organic cyclic compound GO:0071407 9.73 CCL2 CCL3 TGFB1 TNF
17 positive regulation of calcium-mediated signaling GO:0050850 9.67 ADA CCL3
18 positive regulation of calcium ion import GO:0090280 9.67 CCL2 CCL3
19 induction of positive chemotaxis GO:0050930 9.66 CXCL8 VEGFA
20 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.66 CCL2 TLR2
21 macrophage chemotaxis GO:0048246 9.65 CCL2 CCL3
22 response to molecule of bacterial origin GO:0002237 9.65 CXCL8 TLR2
23 positive regulation of protein complex assembly GO:0031334 9.65 TGFB1 TNF VEGFA
24 negative regulation of phagocytosis GO:0050765 9.64 TGFB1 TLR2
25 PERK-mediated unfolded protein response GO:0036499 9.63 CCL2 CXCL8
26 leukotriene biosynthetic process GO:0019370 9.63 ALOX5 LTA4H
27 embryonic digestive tract development GO:0048566 9.63 ADA CXCL8 TNF
28 response to cholesterol GO:0070723 9.62 CCL3 TGFB1
29 protein kinase B signaling GO:0043491 9.62 CCL2 CCL3 TGFB1 TNF
30 cell activation GO:0001775 9.58 CCL3 TGFB1 TLR2
31 inflammatory response GO:0006954 9.56 ALOX5 CCL2 CCL3 CXCL8 LYZ TGFB1
32 astrocyte cell migration GO:0043615 9.54 CCL2 CCL3
33 positive regulation of mononuclear cell migration GO:0071677 9.49 TGFB1 TNF
34 leukotriene metabolic process GO:0006691 9.46 ALOX5 GGT1 LTA4H TLR2
35 lipopolysaccharide-mediated signaling pathway GO:0031663 9.02 CCL2 CCL3 TGFB1 TLR2 TNF
36 immune response GO:0006955 10 CCL2 CCL3 CXCL8 TLR2 TNF

Molecular functions related to Tuberculous Meningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.86 ADA ALOX5 CCL2 CCL3 CXCL8 ENO2
2 identical protein binding GO:0042802 9.73 CCL3 LYZ MMP9 TGFB1 TNF VEGFA
3 chemokine activity GO:0008009 9.33 CCL2 CCL3 CXCL8
4 cytokine activity GO:0005125 9.1 CCL2 CCL3 CXCL8 TGFB1 TNF VEGFA

Sources for Tuberculous Meningitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
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35 IUPHAR
36 KEGG
37 LifeMap
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41 MeSH
42 MESH via Orphanet
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54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
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67 TGDB
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70 UMLS via Orphanet
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