MCID: TBR011
MIFTS: 46

Tuberculous Meningitis

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Tuberculous Meningitis

MalaCards integrated aliases for Tuberculous Meningitis:

Name: Tuberculous Meningitis 50
Tuberculosis, Meningeal 69
Meningitis Tuberculous 52
Tubercular Meningitis 50
Tb Meningitis 50

Classifications:



External Ids:

ICD10 33 A17.0

Summaries for Tuberculous Meningitis

MalaCards based summary : Tuberculous Meningitis, also known as tuberculosis, meningeal, is related to choroiditis and pulmonary tuberculosis. An important gene associated with Tuberculous Meningitis is ADA (Adenosine Deaminase), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Dexamethasone and Anti-Inflammatory Agents have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and t cells, and related phenotypes are immune system and renal/urinary system

Wikipedia : 72 Tuberculous meningitis is also known as TB meningitis or tubercular meningitis. Tuberculous meningitis... more...

Related Diseases for Tuberculous Meningitis

Diseases related to Tuberculous Meningitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 199)
id Related Disease Score Top Affiliating Genes
1 choroiditis 30.2 CCL2 CXCL8 TNF
2 pulmonary tuberculosis 30.2 CCL2 CXCL8 TNF
3 meningitis 11.0
4 mycobacterium malmoense 10.7 CXCL8 TLR2
5 cytomegalovirus retinitis 10.7 CCL2 CXCL8
6 basidiobolomycosis 10.7 CXCL8 TNF
7 spirillary rat-bite fever 10.6 CXCL8 TNF
8 mycobacterium xenopi 10.6 CXCL8 TLR2
9 pneumoconiosis 10.6 ADA CCL2 CXCL8
10 ovarian mucinous adenofibroma 10.6 CCL2 CXCL8 TNF
11 rickettsialpox 10.6 TLR2 TNF
12 cutaneous leishmaniasis 10.6 TNF VEGFA
13 halal setton wang syndrome 10.6 CXCL8 TLR2 TNF
14 sinusitis 10.6 CCL2 CXCL8 TNF
15 mycobacterium kansasii 10.6 CXCL8 TLR2 TNF
16 flinders island spotted fever 10.6 CCL2 CXCL8
17 arthus reaction 10.6 ADA ALOX5 TNF
18 testicular infarct 10.6 CXCL8 TLR2 TNF
19 asbestosis 10.6 CCL2 CXCL8 TNF
20 alopecia 10.6 CCL2 CXCL8 TNF
21 palmoplantar keratosis 10.5 CXCL8 TLR2 TNF
22 antigen-peptide-transporter 2 deficiency 10.5 CCL2 TLR2 TNF
23 churg-strauss syndrome 10.5 CXCL8 NAT2 TNF
24 neovascular glaucoma 10.5 CCL2 CXCL8 TNF
25 opportunistic bacterial infectious disease 10.5 ADA TLR2 TNF
26 askin's tumor 10.5 ADA CCL2 TLR2
27 mesenchymal cell neoplasm 10.5 CCL2 CXCL8 TNF
28 mixed mineral dust pneumoconiosis 10.5 CXCL8 TLR2 TNF
29 mucocutaneous leishmaniasis 10.5 CXCL8 TLR2 TNF
30 keratomalacia 10.5 CXCL8 TLR2 TNF
31 spontaneous ocular nystagmus 10.5 ALOX5 CXCL8 TNF
32 urinary bladder posterior wall cancer 10.5 ADA NPPA VEGFA
33 spondylolysis 10.5 CXCL8 TNF VEGFA
34 premature ovarian failure 12 10.5 CXCL8 TLR2 TNF
35 pneumoconiosis due to talc 10.5 CCL2 TNF
36 uveitis 10.4 CCL2 LYZ TNF
37 ichthyosis, congenital, autosomal recessive 12 10.4 CXCL8 MMP9
38 periampullary adenoma 10.4 CXCL8 TNF VEGFA
39 steatorrhea 10.4 ADA CCL2 CXCL8 TNF
40 posterior urethra cancer 10.4 ENO2 VEGFA
41 early invasive cervical adenocarcinoma 10.4 ENO2 LYZ
42 middle lobe syndrome 10.4 CCL2 CXCL8 VEGFA
43 tuberculosis 10.4
44 tricho onychic dysplasia 10.4 CXCL8 MMP9 TNF
45 myopathy 10.4 CXCL8 MMP9 TNF
46 drug rash with eosinophilia and systemic symptoms 10.4 CXCL8 MMP9
47 renal adenoma 10.3 LYZ TNF VEGFA
48 urethral intrinsic sphincter deficiency 10.3 CCL2 MMP9 TNF
49 schwannoma of ureter 10.3 CCL2 CXCL8
50 burn scar 10.3 CXCL8 MMP9 TNF

Graphical network of the top 20 diseases related to Tuberculous Meningitis:



Diseases related to Tuberculous Meningitis

Symptoms & Phenotypes for Tuberculous Meningitis

MGI Mouse Phenotypes related to Tuberculous Meningitis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.96 LYZ MMP9 TLR2 TNF VEGFA ADA
2 renal/urinary system MP:0005367 9.7 MMP9 NPPA TLR2 VEGFA ADA GGT1
3 respiratory system MP:0005388 9.5 LYZ MMP9 TLR2 TNF VEGFA ADA
4 skeleton MP:0005390 9.23 LYZ MMP9 TLR2 TNF VEGFA ADA

Drugs & Therapeutics for Tuberculous Meningitis

Drugs for Tuberculous Meningitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 77)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3 50-02-2 5743
2 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2
3 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2
4 Antiemetics Phase 4,Phase 2,Phase 3
5 Antineoplastic Agents, Hormonal Phase 4,Phase 2,Phase 3
6 Autonomic Agents Phase 4,Phase 2,Phase 3
7 BB 1101 Phase 4,Phase 2,Phase 3
8 Dexamethasone acetate Phase 4,Phase 2,Phase 3 1177-87-3
9 Gastrointestinal Agents Phase 4,Phase 2,Phase 3
10 glucocorticoids Phase 4,Phase 2,Phase 3
11 HIV Protease Inhibitors Phase 4,Phase 2,Phase 3
12 Hormone Antagonists Phase 4,Phase 2,Phase 3
13 Hormones Phase 4,Phase 2,Phase 3
14 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3
15
protease inhibitors Phase 4,Phase 2,Phase 3
16
Meloxicam Approved, Vet_approved Phase 3 71125-38-7 5281106 54677470
17
Ethambutol Approved Phase 2, Phase 3,Phase 1 74-55-5 3279 14052
18
Pyrazinamide Approved Phase 2, Phase 3,Phase 1 98-96-4 1046
19
Rifampin Approved Phase 2, Phase 3,Phase 1 13292-46-1 5458213 5381226
20
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2, Phase 3 59-30-3 6037
21
Pyridoxal Approved, Nutraceutical Phase 2, Phase 3 66-72-8 1050
22
Pyridoxine Approved, Nutraceutical, Vet_approved Phase 2, Phase 3 65-23-6 1054
23 Analgesics Phase 3,Phase 2
24 Analgesics, Non-Narcotic Phase 3,Phase 2
25 Anti-Inflammatory Agents, Non-Steroidal Phase 3,Phase 2
26 Antirheumatic Agents Phase 3,Phase 2
27 Cyclooxygenase 2 Inhibitors Phase 3
28 Cyclooxygenase Inhibitors Phase 3,Phase 2
29 Anti-Infective Agents Phase 2, Phase 3,Phase 1
30 Cytochrome P-450 CYP3A Inducers Phase 2, Phase 3,Phase 1
31 Nucleic Acid Synthesis Inhibitors Phase 2, Phase 3,Phase 1
32 Anti-Bacterial Agents Phase 2, Phase 3,Phase 1
33 Antibiotics, Antitubercular Phase 2, Phase 3,Phase 1
34 Antitubercular Agents Phase 2, Phase 3, Phase 1
35 Micronutrients Phase 2, Phase 3
36 Trace Elements Phase 2, Phase 3
37 Vitamin B 6 Phase 2, Phase 3
38 Vitamin B Complex Phase 2, Phase 3
39 Vitamins Phase 2, Phase 3
40 Liver Extracts Phase 3
41 Folate Nutraceutical Phase 2, Phase 3
42 Vitamin B9 Nutraceutical Phase 2, Phase 3
43
Aspirin Approved, Vet_approved Phase 2 50-78-2 2244
44
Estradiol Approved, Investigational, Vet_approved Phase 2 50-28-2 5757
45
Ethinyl Estradiol Approved Phase 2 57-63-6 5991
46
Moxifloxacin Approved, Investigational Phase 2 354812-41-2, 151096-09-2 152946
47
Norgestimate Approved Phase 2 35189-28-7 6540478
48
Isoniazid Approved Phase 1, Phase 2 54-85-3 3767
49
Levofloxacin Approved, Investigational Phase 1, Phase 2 100986-85-4 149096
50
Ofloxacin Approved Phase 1, Phase 2 82419-36-1 4583

Interventional clinical trials:

(show all 17)

id Name Status NCT ID Phase Drugs
1 The Relationships Between Gene Polymorphisms of LTA4H and Dexamethasone Treatment for Tuberculous Meningitis Not yet recruiting NCT02588196 Phase 4 Dexamethasone acetate
2 TB-IRIS NSAID Cox-2 Inhibitor Prevention Trial Unknown status NCT02060006 Phase 3 Meloxicam 7.5mg daily for 8 weeks
3 High-dose Rifampicin for the Treatment of Tuberculous Meningitis: a Dose-finding Study Completed NCT02169882 Phase 2, Phase 3 Placebo;Rifampicin;Other TB drugs;Adjuvant dexamethasone
4 Treatment Duration for Abdominal Tuberculosis Completed NCT01124929 Phase 3 RNTCP Category I treatment for 6 months;RNTCP Category I treatment for 9months
5 Adjunctive Corticosteroids for Tuberculous Meningitis in HIV-infected Adults (The ACT HIV Trial) Recruiting NCT03092817 Phase 3 Dexamethasone
6 Leukotriene A4 Hydrolase Stratified Trial of Adjunctive Corticosteroids for HIV-uninfected Adults With Tuberculous Meningitis Not yet recruiting NCT03100786 Phase 3 Dexamethasone
7 A Pilot Study of Adjunctive Aspirin for the Treatment of HIV Negative Adults With Tuberculous Meningitis Completed NCT02237365 Phase 2 81mg aspirin;1000mg aspirin;Placebo
8 Rifampicin Explorative PK Study for Tuberculous Meningitis Comparing Oral and Intravenous Preparation Completed NCT01802502 Phase 2 Rifampicin intravenous;Oral rifampicin
9 Intensified Treatment Regimens for TB Meningitis: PK, PD and Tolerability Study Completed NCT01158755 Phase 2 Moxifloxacin
10 Safety and Immunogenicity of MVA85A Prime and Bacille Calmette-Guerin Boost Vaccination Completed NCT01650389 Phase 2
11 Optimizing Treatment to Improve TBM Outcomes in Children Recruiting NCT02958709 Phase 1, Phase 2 High-dose: RIF, INH, PZA, EMB;High dose: RIF, INH, PZA, LEVO;Standard of care: RIF, INH, PZA, EMB
12 Study of the Safety and Immunogenicity of Bacille Calmette Guerin (BCG) Vaccine Completed NCT00654316 Phase 1
13 Immediate Versus Deferred Antiretroviral Therapy for HIV-Associated Tuberculous Meningitis Unknown status NCT00433719 Combivir and efavirenz
14 Diagnosis of Tuberculous Meningitis by ESAT-6 in CSF Completed NCT01371916
15 Study Of The Long Term Outcome Of Tuberculous Meningitis In Vietnamese Adults Treated With Adjunctive Dexamethasone Completed NCT01317654
16 Driving Reduced AIDS-associated Meningo-encephalitis Mortality Recruiting NCT03226379
17 A Prospective Household Observational Cohort Study of Influenza, Respiratory Syncytial Virus and Other Respiratory Pathogens Community Burden and Transmission Dynamics in South Africa Not yet recruiting NCT02519803

Search NIH Clinical Center for Tuberculous Meningitis

Genetic Tests for Tuberculous Meningitis

Anatomical Context for Tuberculous Meningitis

MalaCards organs/tissues related to Tuberculous Meningitis:

39
Testes, Brain, T Cells, Spinal Cord, Liver, Endothelial, B Cells

Publications for Tuberculous Meningitis

Articles related to Tuberculous Meningitis:

(show top 50) (show all 683)
id Title Authors Year
1
Spotted fever rickettsiae and tuberculous meningitis dual infection presenting as acute encephalitis syndrome: A fatal case report. ( 28748844 )
2017
2
Cytokines do play a role in pathogenesis of tuberculous meningitis: A prospective study from a tertiary care center in India. ( 28716226 )
2017
3
Diagnostic accuracy of Xpert MTB/RIF Ultra for tuberculous meningitis in HIV-infected adults: a prospective cohort study. ( 28919338 )
2017
4
Tuberculous Meningitis in Children and Adults: New Insights for an Ancient Foe. ( 28932979 )
2017
5
Recent advances in the diagnosis and management of tuberculous meningitis. ( 27798497 )
2017
6
Contribution of brain CT in the diagnosis of tuberculous meningitis: a case report from Djibouti. ( 28721934 )
2017
7
Surgical Management of Syringomyelia Associated with Spinal Adhesive Arachnoiditis, a Late Complication of Tuberculous Meningitis: A Case Report. ( 28512616 )
2017
8
A study of neuroendocrine dysfunction in patients of tuberculous meningitis. ( 28716240 )
2017
9
The application of IS6110-baced loop-mediated isothermal amplification (LAMP) in the early diagnosis of tuberculous meningitis. ( 28915693 )
2017
10
Tuberculous meningitis. ( 28884751 )
2017
11
Predictors of adverse outcome in patients of tuberculous meningitis in a multi-centric study from India. ( 28941852 )
2017
12
Cerebrospinal Fluid Leukotriene B4 and Soluble Tumor Necrosis Factor Receptor II Levels and Treatment Outcome in Tuberculous Meningitis. ( 28859433 )
2017
13
Rapid Accurate Identification of Tuberculous Meningitis Among South African Children Using a Novel Clinical Decision Tool. ( 28777205 )
2017
14
Clinical Parameters, Routine Inflammatory Markers, and LTA4H Genotype as Predictors of Mortality Among 608 Patients With Tuberculous Meningitis in Indonesia. ( 28419315 )
2017
15
Cerebrospinal fluid matrix metalloproteinase 9 levels, blood-brain barrier permeability, and treatment outcome in tuberculous meningitis. ( 28704492 )
2017
16
High-performance liquid chromatography with time-programmed fluorescence detection for the quantification of Levofloxacin in human plasma and cerebrospinal fluid in adults with tuberculous meningitis. ( 28756357 )
2017
17
Unusual case of tuberculous meningitis with discordant ventricular and lumbar cerebrospinal fluid; lessons in the era of world-wide migration. ( 28805285 )
2017
18
Xpert MTB/RIF Ultra: a gamechanger for tuberculous meningitis? ( 28919337 )
2017
19
Performance of nested RT-PCR on CSF for tuberculous meningitis diagnosis in HIV-infected patients. ( 28911358 )
2017
20
Tuberculous meningitis and hydrocephalus in Filippino de' Medici. ( 28504108 )
2017
21
A predictive score followed by nucleic acid amplification for adult tuberculous meningitis diagnosis in Southern Brazil. ( 28716254 )
2017
22
Optic disc swelling in a patient with tuberculous meningitis: a diagnostic challenge. ( 28794092 )
2017
23
Neurosyphilis with Concomitant Cryptococcal and Tuberculous Meningitis in a Patient with AIDS: Report of a Unique Case. ( 28928997 )
2017
24
Leukotriene A4 Hydrolase Genotype and HIV Infection Influence Intracerebral Inflammation and Survival From Tuberculous Meningitis. ( 28419368 )
2017
25
Comparison of clinical features and prognostic factors in HIV-negative adults with cryptococcal meningitis and tuberculous meningitis: a retrospective study. ( 28068915 )
2017
26
Diagnosis of tuberculous meningitis: Current scenario from a Tertiary Neurocare Centre in India. ( 28709486 )
2017
27
Prevalence and outcome of headache in tuberculous meningitis. ( 27094524 )
2016
28
Significance of immune response to Mycobacterium tuberculosis culture filtrate protein antigens in cerebrospinal fluid of tuberculous meningitis patients: A search for diagnostic marker. ( 27454259 )
2016
29
Paroxysmal Sympathetic Hyperactivity in a Child with Tuberculous Meningitis A Case Study and Review of Related Literature. ( 27398825 )
2016
30
A study of hyponatremia in tuberculous meningitis. ( 27423581 )
2016
31
Vitamin D status, vitamin D receptor and toll like receptor-2 polymorphisms in tuberculous meningitis: a case-control study. ( 27207494 )
2016
32
Visual pathway abnormalities in tuberculous meningitis. ( 27612674 )
2016
33
Diagnostic accuracy of interferon-gamma release assays for tuberculous meningitis: a meta-analysis. ( 26970159 )
2016
34
Clinical indicators of an early therapeutic response in tuberculous meningitis. ( 27625217 )
2016
35
Development tuberculous meningitis during chemotherapy for CD5-positive diffuse large B-cell lymphoma. ( 27263784 )
2016
36
Multitargeted loop-mediated isothermal amplification for rapid diagnosis of tuberculous meningitis. ( 27084816 )
2016
37
Validation of Thwaites Index for diagnosing tuberculous meningitis in a Colombian population. ( 27772738 )
2016
38
Hyponatremia in children with tuberculous meningitis: A hospital-based cohort study. ( 27857783 )
2016
39
Possible role of transforming growth factor I^ in tuberculous meningitis. ( 27865204 )
2016
40
Neuroimaging in tuberculous meningitis. ( 26954796 )
2016
41
High rate of drug resistance among tuberculous meningitis cases in Shaanxi province, China. ( 27143630 )
2016
42
GeneXpert MTB/Rif to Diagnose Tuberculous Meningitis: Perhaps the First Test but not the Last. ( 26966284 )
2016
43
Comparative study of CD4 and CD45RO T cells and CD20 B cells in cerebrospinal fluid of syphilitic meningitis and tuberculous meningitis patients. ( 27467195 )
2016
44
Microglia activation in a pediatric rabbit model of tuberculous meningitis. ( 27935825 )
2016
45
NaA^ve-pooled pharmacokinetic analysis of pyrazinamide, isoniazid and rifampicin in plasma and cerebrospinal fluid of Vietnamese children with tuberculous meningitis. ( 27039088 )
2016
46
Use of corticosteroids in tuberculous meningitis. ( 27353808 )
2016
47
Cerebrospinal fluid in tuberculous meningitis exhibits only the L-enantiomer of lactic acid. ( 27267176 )
2016
48
Role of (18)F-FDG PET in demonstrating disease burden in patients with tuberculous meningitis. ( 27772758 )
2016
49
Predictors of Neurological Outcome of Tuberculous Meningitis in Childhood: A Prospective Cohort Study From a Developing Country. ( 27655469 )
2016
50
Outcome of tuberculous meningitis in children: the first comprehensive retrospective cohort study in Indonesia. ( 27287643 )
2016

Variations for Tuberculous Meningitis

Expression for Tuberculous Meningitis

Search GEO for disease gene expression data for Tuberculous Meningitis.

Pathways for Tuberculous Meningitis

Pathways related to Tuberculous Meningitis according to GeneCards Suite gene sharing:

(show all 32)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.93 ALOX5 CCL2 CCL3 CXCL8 LTA4H LYZ
2
Show member pathways
13.26 ALOX5 CCL2 CCL3 CXCL8 MMP9 TNF
3
Show member pathways
12.77 CCL2 CCL3 CXCL8 TLR2 TNF
4 12.42 ALOX5 CCL2 TLR2 TNF
5 12.2 MMP9 TLR2 TNF VEGFA
6
Show member pathways
12.19 CCL2 CXCL8 MMP9 TLR2 TNF
7 12.08 MMP9 TLR2 TNF VEGFA
8 11.99 CCL2 MMP9 TNF VEGFA
9
Show member pathways
11.91 CCL2 CCL3 CXCL8
10 11.9 CCL2 CXCL8 MMP9 TNF
11
Show member pathways
11.88 ALOX5 GGT1 LTA4H
12 11.84 CCL2 MMP9 TNF
13 11.79 ENO2 NPPA VEGFA
14 11.78 CXCL8 TLR2 TNF
15 11.77 CCL2 CXCL8 TNF VEGFA
16 11.65 CXCL8 MMP9 VEGFA
17 11.5 CXCL8 TLR2 TNF
18
Show member pathways
11.5 CXCL8 MMP9 TNF VEGFA
19 11.49 ALOX5 CCL2 CXCL8 MMP9 TNF VEGFA
20 11.42 CCL2 TLR2 TNF
21 11.36 CCL2 CCL3 CXCL8 TNF
22 11.35 CCL2 CCL3 CXCL8 MMP9 TNF
23 11.31 CCL2 CXCL8 TLR2 TNF
24 11.24 CCL2 CXCL8 MMP9
25 11.11 CCL2 CCL3 CXCL8 TNF
26 11.08 CCL2 MMP9 TLR2
27 11.05 ALOX5 GGT1 LTA4H
28 11.05 CCL2 CCL3 CXCL8 TLR2 TNF VEGFA
29 10.93 CCL2 VEGFA
30 10.93 CXCL8 TNF
31 10.81 CCL2 CCL3 TNF
32 10.34 ALOX5 GGT1 LTA4H

GO Terms for Tuberculous Meningitis

Cellular components related to Tuberculous Meningitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.7 ALOX5 CCL2 CCL3 CXCL8 LTA4H LYZ
2 ficolin-1-rich granule lumen GO:1904813 9.43 ALOX5 LTA4H MMP9
3 extracellular space GO:0005615 9.4 ADA ALOX5 CCL2 CCL3 CXCL8 ENO2
4 tertiary granule lumen GO:1904724 9.33 LTA4H LYZ MMP9

Biological processes related to Tuberculous Meningitis according to GeneCards Suite gene sharing:

(show all 29)
id Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.91 CCL2 CCL3 CXCL8 TLR2 TNF
2 neutrophil degranulation GO:0043312 9.89 ALOX5 LTA4H LYZ MMP9 TLR2
3 cellular response to tumor necrosis factor GO:0071356 9.81 CCL2 CCL3 CXCL8
4 cellular response to organic cyclic compound GO:0071407 9.72 CCL2 CCL3 TNF
5 cellular response to interleukin-1 GO:0071347 9.71 CCL2 CCL3 CXCL8
6 chemokine-mediated signaling pathway GO:0070098 9.7 CCL2 CCL3 CXCL8
7 neutrophil chemotaxis GO:0030593 9.65 CCL2 CCL3 CXCL8
8 response to hypoxia GO:0001666 9.65 ADA CCL2 NPPA TLR2 VEGFA
9 positive regulation of calcium-mediated signaling GO:0050850 9.64 ADA CCL3
10 macrophage differentiation GO:0030225 9.63 MMP9 VEGFA
11 positive regulation of chemokine production GO:0032722 9.63 TLR2 TNF
12 positive regulation of calcium ion import GO:0090280 9.62 CCL2 CCL3
13 cell activation GO:0001775 9.62 CCL3 TLR2
14 positive regulation of leukocyte migration GO:0002687 9.61 CCL2 VEGFA
15 induction of positive chemotaxis GO:0050930 9.61 CXCL8 VEGFA
16 positive regulation of tumor necrosis factor production GO:0032760 9.61 CCL2 CCL3 TLR2
17 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.6 CCL2 TLR2
18 macrophage chemotaxis GO:0048246 9.59 CCL2 CCL3
19 response to molecule of bacterial origin GO:0002237 9.58 CXCL8 TLR2
20 defense response to Gram-positive bacterium GO:0050830 9.58 TLR2 TNF
21 positive regulation of cell adhesion GO:0045785 9.58 CCL2 TNF VEGFA
22 leukotriene biosynthetic process GO:0019370 9.57 ALOX5 LTA4H
23 PERK-mediated unfolded protein response GO:0036499 9.56 CCL2 CXCL8
24 protein kinase B signaling GO:0043491 9.54 CCL2 CCL3 TNF
25 embryonic digestive tract development GO:0048566 9.5 ADA CXCL8 TNF
26 inflammatory response GO:0006954 9.5 ALOX5 CCL2 CCL3 CXCL8 LYZ TLR2
27 astrocyte cell migration GO:0043615 9.46 CCL2 CCL3
28 lipopolysaccharide-mediated signaling pathway GO:0031663 9.46 CCL2 CCL3 TLR2 TNF
29 leukotriene metabolic process GO:0006691 8.92 ALOX5 GGT1 LTA4H TLR2

Molecular functions related to Tuberculous Meningitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 chemokine activity GO:0008009 9.13 CCL2 CCL3 CXCL8
2 cytokine activity GO:0005125 9.02 CCL2 CCL3 CXCL8 TNF VEGFA

Sources for Tuberculous Meningitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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