MCID: TBR011
MIFTS: 51

Tuberculous Meningitis malady

Infectious category

Summaries for Tuberculous Meningitis

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Tuberculous meningitis is also known as TB meningitis or tubercular meningitis. more...

MalaCards: Tuberculous Meningitis, also known as tuberculosis, meningeal, is related to tuberculosis and bacterial meningitis. An important gene associated with Tuberculous Meningitis is ADA (adenosine deaminase), and among its related pathways are Malaria and Rheumatoid arthritis. The compounds pge2 and cycloheximide have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and t cells, and related mouse phenotypes are skeleton and liver/biliary system.

Aliases & Classifications for Tuberculous Meningitis

Sources:
43NIH Rare Diseases, 45Novoseek, 61UMLS, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious


Aliases & Descriptions:

tuberculous meningitis 43
tuberculosis, meningeal 61
meningitis tuberculous 45
tubercular meningitis 43
tb meningitis 43


External Ids:

ICD1025 A17.0

Related Diseases for Tuberculous Meningitis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Tuberculous Meningitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 294)
idRelated DiseaseScoreTop Affiliating Genes
1tuberculosis31.2LYZ, ADA, ALOX5, IL1B, IL10, POMC
2bacterial meningitis30.5ADA, IL1B, IL8, CRP, TLR2, CCL3
3aseptic meningitis30.3ADA, CCL3
4vasculitis30.3CRP, TNF, MBL2
5pulmonary tuberculosis30.3ADA, IL10, MBL2, IFNG, TLR2, CCL3
6panic disorder30.0POMC
7visceral leishmaniasis30.0IL10, IFNG
8systemic lupus erythematosus30.0ADA, ALOX5, IL10, CRP, TNF, MBL2
9miliary tuberculosis10.7
10arachnoiditis10.6
11syringomyelia10.4
12n syndrome10.4
13neonatal meningitis10.3
14internuclear ophthalmoplegia10.2
15venous thrombosis10.1
16stroke, ischemic10.0
17bone fracture10.0
18tuberculous epididymitis10.0
19central nervous system tuberculosis10.0
20status epilepticus10.0
21diabetic ketoacidosis10.0
22lutembacher's syndrome10.0
23sensorineural hearing loss10.0
24asperger syndrome10.0
25brain edema10.0
26panhypopituitarism10.0
27agoraphobia10.0
28atypical teratoid rhabdoid tumor10.0
29oculopharyngeal muscular dystrophy10.0
30cerebral lymphoma10.0
31obstructive hydrocephalus10.0
32sarcoid meningitis10.0
33sick sinus syndrome10.0
34bronchopneumonia10.0
35acute leukemia10.0
36arteriosclerosis10.0
37strabismus10.0
38toxoplasmosis10.0
39germinoma10.0
40herpes simplex encephalitis10.0
41kikuchi disease10.0
42periarteritis nodosa10.0
43rhabdoid tumor10.0
44syringobulbia10.0
45cerebral arteriosclerosis10.0
46neurosarcoidosis10.0
47epididymitis10.0
48moyamoya disease10.0
49multidrug-resistant tuberculosis10.0
50chronic granulomatous disease10.0

Graphical network of the top 20 diseases related to Tuberculous Meningitis:



Diseases related to tuberculous meningitis

Clinical Features for Tuberculous Meningitis

Drugs & Therapeutics for Tuberculous Meningitis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Tuberculous Meningitis

Drug clinical trials:

Search ClinicalTrials for Tuberculous Meningitis

Search NIH Clinical Center for Tuberculous Meningitis

Search CenterWatch for Tuberculous Meningitis

Genetic Tests for Tuberculous Meningitis

Anatomical Context for Tuberculous Meningitis

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Tuberculous Meningitis:

33
Spinal cord, Brain, T cells, B lymphoblasts, B cells, Endothelial, Medulla oblongata

Animal Models for Tuberculous Meningitis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Tuberculous Meningitis

Sources:
51PubMed
See all sources

Articles related to Tuberculous Meningitis:

(show top 50)    (show all 558)
idTitleAuthorsYear
1
Unusual fundus examination findings in tuberculous meningitis. (23396930)
2013
2
Comparison of clinical and CSF profiles in children with tuberculous and pyogenic meningitis; role of CSF protein: glucose ratio as diagnostic marker of tuberculous meningitis. (23894896)
2013
3
An iTRAQ approach to quantitative proteome analysis of cerebrospinal fluid from patients with tuberculous meningitis. (24056169)
2013
4
Simultaneous cryptococcal and tuberculous meningitis in a patient with systemic lupus erythematosus. (23751767)
2013
5
Primary Diffuse Leptomeningeal Gliomatosis Mimicking Tuberculous Meningitis. (24284232)
2013
6
Tuberculous meningitis: do modern diagnostic tools offer better prognosis prediction? (23540083)
2013
7
Directly observed treatment, short course in tuberculous meningitis: Indian perspective. (23661969)
2013
8
Intensified regimen containing rifampicin and moxifloxacin for tuberculous meningitis: an open-label, randomised controlled phase 2 trial. (23103177)
2013
9
Management of hydrocephalus in tuberculous meningitis. (22919205)
2012
10
MR angiography in tuberculous meningitis. (22371623)
2012
11
Case of Mycobacterium tuberculosis meningitis: Gram staining as a useful initial diagnostic clue for tuberculous meningitis. (22476652)
2012
12
Description of primary multidrug-resistant tuberculous meningitis in an Italian child. (21711151)
2012
13
Tuberculous meningitis in adults: a review of 160 cases. (22619611)
2012
14
Computed tomography angiography in patients with tuberculous meningitis. (22446495)
2012
15
Importance of differentiating Mycobaterium bovis in tuberculous meningitis. (22368776)
2011
16
Impact of bacille Calmette-GuAcrin vaccination on neuroradiological manifestations of pediatric tuberculous meningitis. (19794100)
2010
17
Role of aspirin in tuberculous meningitis: a randomized open label placebo controlled trial. (20421121)
2010
18
Correlation of CSF proinflammatory cytokines with MRI in tuberculous meningitis. (20004599)
2010
19
Duration of anti-tubercular treatment in tuberculous meningitis: challenges and opportunity. (21045495)
2010
20
Neurological and systemic complications of tuberculous meningitis and its treatment at Auckland City Hospital, New Zealand. (20605462)
2010
21
Cerebral salt wasting syndrome in tuberculous meningitis. (21375206)
2010
22
Tuberculous meningitis: a uniform case definition for use in clinical research. (20822958)
2010
23
Tuberculous meningitis in a patient with acute human immunodeficiency virus infection. (20392364)
2010
24
Tuberculous meningitis in HIV-infected and non-infected patients: comparison of cerebrospinal fluid findings. (19146759)
2009
25
Diagnostic value of early secreted antigenic target-6 for the diagnosis of tuberculous meningitis patients. (19669088)
2009
26
Atypical cerebrospinal fluid profile in tuberculous meningitis. (19299285)
2009
27
Drug susceptibility profiling of tuberculous meningitis. (18173886)
2008
28
Presentation and outcome of tuberculous meningitis in adults in the province of Castellon, Spain: a retrospective study. (18205976)
2008
29
Tuberculous and syphilitic meningitis in a patient infected with the human immunodeficiency virus. (17409609)
2007
30
Pretreatment intracerebral and peripheral blood immune responses in Vietnamese adults with tuberculous meningitis: diagnostic value and relationship to disease severity and outcome. (16424233)
2006
31
Differentiation of tuberculous meningitis from acute bacterial meningitis using simple clinical and laboratory parameters. (16626906)
2006
32
Tuberculous meningitis in adults: MRI contribution to the diagnosis in 29 patients. (16839793)
2006
33
Value of early follow-up CT in paediatric tuberculous meningitis. (16079979)
2005
34
Role of neuroendoscopy in the management of patients with tuberculous meningitis hydrocephalus. (15983833)
2005
35
It is too early to discount the contribution of isoniazid to the treatment of tuberculous meningitis. (15942887)
2005
36
Tuberculous meningitis masked by delirium in an alcohol-dependent patient: a case report. (16279879)
2005
37
Tuberculous meningitis with initial manifestation of isolated oculomotor nerve palsy. (15835285)
2005
38
Dexamethasone for Treatment of Tuberculous Meningitis in Adolescents and Adults. (15963328)
2005
39
Tuberculous meningitis with multiple intracranial tuberculomas mimicking neurocysticercosis clinical and radiological findings. (16377875)
2005
40
Dexamethasone for the treatment of tuberculous meningitis in adolescents and adults. (15496623)
2004
41
Asymptomatic spinal arachnoiditis in patients with tuberculous meningitis. (14504848)
2003
42
Tuberculous meningitis in a district hospital from Southern Ethiopia. (15296413)
2003
43
The possible role of cerebrospinal fluid adenosine deaminase activity in the diagnosis of tuberculous meningitis in adults. (11792470)
2002
44
Tuberculous meningitis following correction of kyphosis by spinal osteotomy. A case report. (12063339)
2002
45
Adjunctive thalidomide therapy of childhood tuberculous meningitis: possible anti-inflammatory role. (10961786)
2000
46
Tuberculous meningitis. (12295051)
1999
47
Concentrations of interferon gamma, tumor necrosis factor alpha, and interleukin-1 beta in the cerebrospinal fluid of children treated for tuberculous meningitis. (8645841)
1995
48
Arachnoiditis ossificans with arachnoid cyst after cranial tuberculous meningitis. (2320252)
1990
49
Rapid diagnosis of lymphocytic meningitis by frequency-pulsed electron capture gas-liquid chromatography: differentiation of tuberculous, cryptococcal, and viral meningitis. (886006)
1977
50
CHEMOTHERAPY of miliary tuberculosis and tuberculous meningitis; a Public Health Service cooperative investigation. (13073310)
1953

Genetic Variations for Tuberculous Meningitis

Expression for genes affiliated with Tuberculous Meningitis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Tuberculous Meningitis

Search GEO for disease gene expression data for Tuberculous Meningitis.

Pathways for genes affiliated with Tuberculous Meningitis

Sources:
30KEGG, 12EMD Millipore, 38NCBI BioSystems Database, 52QIAGEN, 50PharmGKB, 4Cell Signaling Technology, 54Reactome, 53R&D Systems
See all sources

Pathways related to Tuberculous Meningitis according to GeneCards/GeneDecks:

(show all 40)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2TLR2
210.2TLR2
3
Transcription Role of VDR in regulation of genes involved in osteoporosis
Hide members
10.2IFNG
4
Hide members
10.2IFNG
510.2IL8
6
Hide members
10.0ALOX5, TLR2
7
Hide members
9.9CCL3
8
Hide members
9.7ALOX5, GGT1
99.7IL1B, TNF
109.7IL8, POMC, IFNG
119.6IL1B, IL8, TLR2
129.5IFNG, TNF, IL8
13
Hide members
9.5IFNG, TNF, IL8
149.5IL1B, TNF, TLR2
15
Hide members
9.4TNF, IL8, IL1B
169.4IL1B, IL8, TNF
179.4TNF, IL10, IL1B
18
Hide members
9.2CCL3, IFNG, IL1B
19
Hide members
9.2IL1B, TNF, IFNG, TLR2
209.2IL1B, TNF, IFNG, TLR2
219.2TLR2, TNF, IL8, IL1B
22
Hide members
9.2IL1B, IL8, TNF, TLR2
23
Hide members
9.1IFNG, TNF, IL8, IL1B
249.1IFNG, TNF, IL10, IL1B
25
Development PDGF signaling via STATs and NF-kB
Hide members
9.1IFNG, TNF, IL10, IL1B
26
Hide members
9.1IL1B, IL10, TNF, IFNG
279.1TNF, IL10, IL8, IL1B
289.1TNF, IL10, IL8, IL1B
299.1IL1B, TNF, CCL3
308.9CCL3, IFNG, IL8, IL1B
31
Immune response Bacterial infections in normal airways
Hide members
8.9TLR2, IFNG, TNF, IL8, IL1B
32
Hide members
8.9IL1B, IL8, TNF, IFNG, TLR2
33
Hide members
8.8TLR2, IFNG, TNF, IL10, IL1B
348.8TLR2, IFNG, TNF, IL10, IL1B
35
Hide members
8.8CCL3, IFNG, TNF, IL10
368.8IFNG, TNF, IL10, IL8, IL1B
378.5TLR2, IFNG, TNF, IL10, IL8, IL1B
388.3ALOX5, GGT1, IL1B, CRP, TNF, IFNG
39
Hide members
8.2IL1B, IL8, IL10, TNF, TLR2, CCL3
40
Hide members
7.9CCL3, TLR2, IFNG, TNF, IL10, IL8

Compounds for genes affiliated with Tuberculous Meningitis

Sources:
45Novoseek, 60Tocris Bioscience, 29IUPHAR, 2BitterDB, 11DrugBank, 50PharmGKB, 24HMDB
See all sources

Compounds related to Tuberculous Meningitis according to GeneCards/GeneDecks:

(show top 50)    (show all 184)
idCompoundScoreTop Affiliating Genes
1pge24510.7POMC
2cycloheximide4510.6TLR2
3rolipram45 60 2912.5ALOX5, ADA
4tenidap45 2911.4ALOX5
5hydrocortisone45 2 60 1113.3IL8, POMC
6pentoxifylline45 1111.3GGT1
7prednisolone45 29 1112.1MBL2, CRP, POMC
8indomethacin45 60 29 1112.9GGT1, POMC, ALOX5
9gm-csf45 2910.9IL10, TNF, IFNG
10cyclosporin a45 29 6011.7ADA, CCL3, IFNG
11ivig459.7CRP, IFNG
12fmlp459.4CCL3, ALOX5, ADA
13ribavirin45 50 1111.3GGT1, ADA, IFNG, MBL2, IL10
14taurine chloramine459.3IL8, IL1B, IFNG, TNF
15imiquimod45 29 60 1112.2IL8, IL10, TNF, IFNG, TLR2
165 aminosalicylic acid459.2ALOX5, IL1B, TNF, IL10, IL8
17budesonide45 50 1111.2IL1B, IL8, POMC, IFNG, TNF
18aspartate459.1POMC, MBL2, ADA, ENO2, ALOX5
19il-12459.1IL8, IL1B, IL10, TNF, IFNG
20fluticasone propionate45 50 60 1112.1POMC, TNF, IL1B, IL8, IFNG
21sulfasalazine45 29 50 1112.1IL8, IL1B, ALOX5, CRP, TNF
22tuberculin459.0ENO2, ADA, IL10, MBL2, IFNG
23tacrolimus45 50 1110.9IFNG, GGT1, ALOX5, TLR2, CCL3
24infliximab45 50 1110.9IFNG, TNF, IL1B, IL10, CRP
25toxin-1458.9IL1B, TNF, IL10, IL8, CCL3
26etanercept45 50 1110.9IL1B, IL10, CRP, IFNG, TNF, IL8
27mip 1alpha458.8TNF, CCL3, IL8, IL1B, IL10
28gold sodium thiomalate458.8IL1B, TNF, IFNG, IL8
29polymyxin b458.8IL1B, TLR2, IL8, IL10, TNF, IFNG
30triptolide458.8CCL3, IFNG, TNF, IL8, IL1B
31groalpha458.8IL8, IL10, IL1B, CCL3, TNF
32rantes458.7CCL3, TLR2, IFNG, MBL2, TNF, IL1B
33dexamethasone45 50 29 1111.7ALOX5, ENO2, GGT1, POMC, TLR2, ADA
348-isoprostane458.7IL8, IL10, CRP, TNF, CCL3
35poly(i-c)458.6IL1B, IL8, TNF, IFNG, CCL3, TLR2
36l-nmma458.6TNF, CCL3, IFNG, NPPA, IL1B
37tarc458.5IFNG, CCL3, IL10, TNF, IL8
38leukotriene b445 60 2410.5TLR2, CCL3, TNF, IL8, IL1B, ALOX5
39lipoteichoic acid458.4IL8, IL1B, IL10, MBL2, TLR2, CCL3
40peptidoglycan45 299.4TLR2, IL8, CCL3, TNF, IL1B, IL10
41polyinosinic-polycytidylic acid458.4IFNG, CCL3, IL1B, IL8, IL10, TLR2
42il 10458.4IL1B, TNF, IFNG, IL8, TLR2, CCL3
43ccl345 299.4IL1B, IL8, IL10, TNF, IFNG, TLR2
44simvastatin45 50 60 29 11 2413.3CCL3, IL8, CRP, TNF, IFNG, TLR2
45histamine45 29 249.9TNF, ADA, ALOX5, IL1B, IL8, IL10
46neopterin457.9CCL3, ADA, IL1B, IL8, IL10, CRP
47sb 20358045 608.8IL8, ALOX5, IL10, CRP, TNF, IFNG
48methotrexate45 50 119.8GGT1, ENO2, IL1B, IL10, CRP, ADA
49nitric oxide45 11 249.0CCL3, TLR2, IFNG, MBL2, TNF, ENO2
50vegf456.1NPPA, POMC, TNF, MBL2, IFNG, TLR2

GO Terms for genes affiliated with Tuberculous Meningitis

Sources:
16Gene Ontology
See all sources

Cellular components related to Tuberculous Meningitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.3ADA, TNF, IFNG, TLR2
2extracellular regionGO:0055767.0TNF, MBL2, IFNG, CCL3, NPPA, CRP
3extracellular spaceGO:0056156.6LYZ, CCL3, IFNG, MBL2, TNF, NPPA

Biological processes related to Tuberculous Meningitis according to GeneCards/GeneDecks:

(show all 39)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of cytokine secretion involved in immune responseGO:00274010.5IL10
2positive regulation of vitamin D biosynthetic processGO:06055710.2TNF, IFNG
3opsonizationGO:00822810.1MBL2, CRP
4positive regulation of MHC class II biosynthetic processGO:04534810.1IFNG, IL10
5negative regulation of interleukin-17 productionGO:03270010.1IFNG, TLR2
6receptor biosynthetic processGO:03280010.1IL10, TNF
7positive regulation of interleukin-6 biosynthetic processGO:04541010.1IFNG, IL1B
8sequestering of triglycerideGO:03073010.0IL1B, TNF
9positive regulation of heterotypic cell-cell adhesionGO:03411610.0IL1B, TNF
10positive regulation of fever generationGO:03162210.0IL1B, TNF
11embryonic digestive tract developmentGO:04856610.0ADA, IL8, TNF
12negative regulation of lipid storageGO:01088810.0TNF, CRP
13negative regulation of interleukin-12 productionGO:0326959.9IL10, TLR2
14positive regulation of cytokine secretionGO:0507159.9TLR2, TNF, IL10
15response to molecule of bacterial originGO:0022379.9IL8, IL10
16defense response to bacteriumGO:0427429.8LYZ, IL10, MBL2, IFNG
17positive regulation of NF-kappaB import into nucleusGO:0423469.8TLR2, TNF, IL1B
18positive regulation of calcidiol 1-monooxygenase activityGO:0605599.8IFNG, TNF, IL1B
19positive regulation of chemokine biosynthetic processGO:0450809.8IL1B, TNF, IFNG
20positive regulation of membrane protein ectodomain proteolysisGO:0510449.8IFNG, TNF, IL1B
21positive regulation of interleukin-6 productionGO:0327559.8TLR2, TNF, IL1B
22cellular response to lipopolysaccharideGO:0712229.7IFNG, IL10, IL8
23positive regulation of tumor necrosis factor productionGO:0327609.7IFNG, TLR2, CCL3
24defense response to Gram-positive bacteriumGO:0508309.7CRP, TNF, MBL2, TLR2
25cell activationGO:0017759.6CCL3, TNF
26positive regulation of nitric oxide biosynthetic processGO:0454299.6TLR2, IFNG, TNF, IL1B
27calcium-mediated signalingGO:0197229.5IL8, TNF, CCL3
28positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.4IL1B, IL10, TNF
29cellular response to organic cyclic compoundGO:0714079.4IL1B, TNF, CCL3
30negative regulation of growth of symbiont in hostGO:0441309.4IL10, TNF, MBL2, IFNG, TLR2
31protein kinase B signaling cascadeGO:0434919.4CCL3, TNF, IL1B
32regulation of I-kappaB kinase/NF-kappaB cascadeGO:0431229.4IL1B, TNF
33MAPK cascadeGO:0001659.4CCL3, TNF, IL1B
34regulation of insulin secretionGO:0507969.3IFNG, TNF, IL1B
35neutrophil chemotaxisGO:0305939.3CCL3, IFNG, IL8, IL1B
36lipopolysaccharide-mediated signaling pathwayGO:0316639.2IL1B, TNF, TLR2, CCL3
37cell-cell signalingGO:0072679.1CCL3, POMC, IL10, IL1B
38positive regulation of transcription from RNA polymerase II promoterGO:0459448.9TLR2, IFNG, TNF, POMC, IL10, IL1B
39inflammatory responseGO:0069548.1CCL3, TLR2, TNF, CRP, IL10, IL8

Molecular functions related to Tuberculous Meningitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.1IL1B, IL10, TNF, IFNG

Products for genes affiliated with Tuberculous Meningitis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Tuberculous Meningitis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet