MCID: TBR011
MIFTS: 40

Tuberculous Meningitis malady

Infectious diseases category

Summaries for Tuberculous Meningitis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Tuberculous meningitis is also known as TB meningitis or tubercular meningitis. more...

MalaCards: Tuberculous Meningitis, also known as tuberculosis, meningeal, is related to meningitis and tuberculosis. An important gene associated with Tuberculous Meningitis is ADA (adenosine deaminase), and among its related pathways are Malaria and Rheumatoid arthritis. The compounds pge2 and cycloheximide have been mentioned in the context of this disorder. Related mouse phenotypes are skeleton and liver/biliary system.

Aliases & Classifications for Tuberculous Meningitis

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42NIH Rare Diseases, 44Novoseek, 60UMLS, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Aliases & Descriptions:

tuberculous meningitis 42
tuberculosis, meningeal 60
meningitis tuberculous 44
tubercular meningitis 42
tb meningitis 42


External Ids:

ICD1025 A17.0

Related Diseases for Tuberculous Meningitis

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17GeneCards, 18GeneDecks
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Diseases related to Tuberculous Meningitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 302)
idRelated DiseaseScoreTop Affiliating Genes
1meningitis32.0LYZ, ADA, IL1B, IL8, CRP, MBL2
2tuberculosis31.1LYZ, ADA, ALOX5, IL1B, IL10, POMC
3bacterial meningitis30.4ADA, IL1B, IL8, CRP, TLR2, CCL3
4aseptic meningitis30.2ADA, CCL3
5vasculitis30.2CRP, TNF, MBL2
6pulmonary tuberculosis30.2ADA, IL10, MBL2, IFNG, TLR2, CCL3
7extrapulmonary tuberculosis30.0ADA
8ischemia30.0ALOX5
9herpes simplex30.0TLR2
10panic disorder30.0POMC
11leishmaniasis30.0IL10, IFNG
12hepatitis30.0GGT1, TLR2
13encephalitis30.0IL1B, TLR2, CCL3
14alcohol dependence30.0GGT1
15visceral leishmaniasis30.0IL10, IFNG
16hypertension30.0GGT1, POMC, CRP, NPPA
17sarcoidosis30.0LYZ, ADA, IL1B, TNF, IFNG, CCL3
18leukemia30.0LYZ, ADA, ALOX5, IL1B, TNF, MBL2
19systemic lupus erythematosus29.9ADA, ALOX5, IL10, CRP, TNF, MBL2
20hydrocephalus10.7
21cerebritis10.6
22miliary tuberculosis10.6
23arachnoiditis10.6
24syringomyelia10.4
25chronic meningitis10.3
26internuclear ophthalmoplegia10.2
27cervicitis10.2
28cranial nerve palsy10.2
29ophthalmoplegia10.2
30stroke, ischemic10.0
31bone fracture10.0
32tuberculous epididymitis10.0
33central nervous system tuberculosis10.0
34multidrug-resistant tuberculosis10.0
35status epilepticus10.0
36diabetic ketoacidosis10.0
37choroiditis10.0
38sensorineural hearing loss10.0
39brain edema10.0
40panhypopituitarism10.0
41agoraphobia10.0
42atypical teratoid rhabdoid tumor10.0
43neuronitis10.0
44oculopharyngeal muscular dystrophy10.0
45cerebral lymphoma10.0
46obstructive hydrocephalus10.0
47sick sinus syndrome10.0
48bronchopneumonia10.0
49acute leukemia10.0
50hepatitis a10.0

Graphical network of the top 20 diseases related to Tuberculous Meningitis:



Diseases related to tuberculous meningitis

Clinical Features for Tuberculous Meningitis

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Drugs & Therapeutics for Tuberculous Meningitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Tuberculous Meningitis

Drug clinical trials:

Search ClinicalTrials for Tuberculous Meningitis

Search NIH Clinical Center for Tuberculous Meningitis

Search CenterWatch for Tuberculous Meningitis

Genetic Tests for Tuberculous Meningitis

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Anatomical Context for Tuberculous Meningitis

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Animal Models for Tuberculous Meningitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Tuberculous Meningitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053909.3ALOX5, GGT1, IL1B
2MP:00053708.8ADA, IL10, POMC, TNF, IFNG, TLR2
3MP:00020068.6IFNG, TNF, POMC, IL10, IL1B
4MP:00053857.8IFNG, IL1B, IL10, POMC, CRP, NPPA
5MP:00053767.4CCL3, ALOX5, GGT1, POMC, CRP, NPPA
6MP:00053976.8IFNG, ALOX5, GGT1, IL8, TLR2, POMC
7MP:00053876.3GGT1, IL1B, IL8, IL10, POMC, CRP

Publications for Tuberculous Meningitis

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Genetic Variations for Tuberculous Meningitis

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Expression for genes affiliated with Tuberculous Meningitis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Tuberculous Meningitis

Search GEO for disease gene expression data for Tuberculous Meningitis.

Pathways for genes affiliated with Tuberculous Meningitis

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29KEGG, 12EMD Millipore, 37NCBI BioSystems Database, 51QIAGEN, 49PharmGKB, 4Cell Signaling Technology, 53Reactome, 52R&D Systems
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Pathways related to Tuberculous Meningitis according to GeneCards/GeneDecks:

(show all 40)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2TLR2
210.2TLR2
3
Transcription Role of VDR in regulation of genes involved in osteoporosis
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10.2IFNG
4
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10.2IFNG
510.2IL8
6
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10.0ALOX5, TLR2
7
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9.9CCL3
8
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9.7ALOX5, GGT1
99.7IL1B, TNF
109.7IL8, POMC, IFNG
119.6IL1B, IL8, TLR2
129.5IFNG, TNF, IL8
13
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9.5IFNG, TNF, IL8
149.5IL1B, TNF, TLR2
15
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9.4TNF, IL8, IL1B
169.4IL1B, IL8, TNF
179.4TNF, IL10, IL1B
18
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9.2CCL3, IFNG, IL1B
19
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9.2IL1B, TNF, IFNG, TLR2
209.2IL1B, TNF, IFNG, TLR2
219.2TLR2, TNF, IL8, IL1B
22
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9.2IL1B, IL8, TNF, TLR2
23
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9.1IFNG, TNF, IL8, IL1B
249.1IFNG, TNF, IL10, IL1B
25
Development PDGF signaling via STATs and NF-kB
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9.1IFNG, TNF, IL10, IL1B
26
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9.1IL1B, IL10, TNF, IFNG
279.1TNF, IL10, IL8, IL1B
289.1TNF, IL10, IL8, IL1B
299.1IL1B, TNF, CCL3
308.9CCL3, IFNG, IL8, IL1B
31
Immune response Bacterial infections in normal airways
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8.9TLR2, IFNG, TNF, IL8, IL1B
32
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8.9IL1B, IL8, TNF, IFNG, TLR2
33
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8.8TLR2, IFNG, TNF, IL10, IL1B
348.8TLR2, IFNG, TNF, IL10, IL1B
35
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8.8CCL3, IFNG, TNF, IL10
368.8IFNG, TNF, IL10, IL8, IL1B
378.5TLR2, IFNG, TNF, IL10, IL8, IL1B
388.3ALOX5, GGT1, IL1B, CRP, TNF, IFNG
39
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8.2IL1B, IL8, IL10, TNF, TLR2, CCL3
40
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7.9CCL3, TLR2, IFNG, TNF, IL10, IL8

Compounds for genes affiliated with Tuberculous Meningitis

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Sources:
44Novoseek, 59Tocris Bioscience, 28IUPHAR, 2BitterDB, 11DrugBank, 49PharmGKB, 24HMDB
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Compounds related to Tuberculous Meningitis according to GeneCards/GeneDecks:

(show top 50)    (show all 184)
idCompoundScoreTop Affiliating Genes
1pge24410.7POMC
2cycloheximide4410.6TLR2
3rolipram44 59 2812.5ALOX5, ADA
4tenidap44 2811.4ALOX5
5hydrocortisone44 2 59 1113.3IL8, POMC
6pentoxifylline44 1111.3GGT1
7prednisolone44 28 1112.1MBL2, CRP, POMC
8indomethacin44 59 28 1112.9GGT1, POMC, ALOX5
9gm-csf44 2810.9IL10, TNF, IFNG
10cyclosporin a44 28 5911.7ADA, CCL3, IFNG
11ivig449.7CRP, IFNG
12fmlp449.4CCL3, ALOX5, ADA
13ribavirin44 49 1111.3GGT1, ADA, IFNG, MBL2, IL10
14taurine chloramine449.3IL8, IL1B, IFNG, TNF
15imiquimod44 28 59 1112.2IL8, IL10, TNF, IFNG, TLR2
165 aminosalicylic acid449.2ALOX5, IL1B, TNF, IL10, IL8
17budesonide44 49 1111.2IL1B, IL8, POMC, IFNG, TNF
18aspartate449.1POMC, MBL2, ADA, ENO2, ALOX5
19il-12449.1IL8, IL1B, IL10, TNF, IFNG
20fluticasone propionate44 49 59 1112.1POMC, TNF, IL1B, IL8, IFNG
21sulfasalazine44 28 49 1112.1IL8, IL1B, ALOX5, CRP, TNF
22tuberculin449.0ENO2, ADA, IL10, MBL2, IFNG
23tacrolimus44 49 1110.9IFNG, GGT1, ALOX5, TLR2, CCL3
24infliximab44 49 1110.9IFNG, TNF, IL1B, IL10, CRP
25toxin-1448.9IL1B, TNF, IL10, IL8, CCL3
26etanercept44 49 1110.9IL1B, IL10, CRP, IFNG, TNF, IL8
27mip 1alpha448.8TNF, CCL3, IL8, IL1B, IL10
28gold sodium thiomalate448.8IL1B, TNF, IFNG, IL8
29polymyxin b448.8IL1B, TLR2, IL8, IL10, TNF, IFNG
30triptolide448.8CCL3, IFNG, TNF, IL8, IL1B
31groalpha448.8IL8, IL10, IL1B, CCL3, TNF
32rantes448.7CCL3, TLR2, IFNG, MBL2, TNF, IL1B
33dexamethasone44 49 28 1111.7ALOX5, ENO2, GGT1, POMC, TLR2, ADA
348-isoprostane448.7IL8, IL10, CRP, TNF, CCL3
35poly(i-c)448.6IL1B, IL8, TNF, IFNG, CCL3, TLR2
36l-nmma448.6TNF, CCL3, IFNG, NPPA, IL1B
37tarc448.5IFNG, CCL3, IL10, TNF, IL8
38leukotriene b444 59 2410.5TLR2, CCL3, TNF, IL8, IL1B, ALOX5
39lipoteichoic acid448.4IL8, IL1B, IL10, MBL2, TLR2, CCL3
40peptidoglycan44 289.4TLR2, IL8, CCL3, TNF, IL1B, IL10
41polyinosinic-polycytidylic acid448.4IFNG, CCL3, IL1B, IL8, IL10, TLR2
42il 10448.4IL1B, TNF, IFNG, IL8, TLR2, CCL3
43ccl344 289.4IL1B, IL8, IL10, TNF, IFNG, TLR2
44simvastatin44 49 59 28 11 2413.3CCL3, IL8, CRP, TNF, IFNG, TLR2
45histamine44 28 249.9TNF, ADA, ALOX5, IL1B, IL8, IL10
46neopterin447.9CCL3, ADA, IL1B, IL8, IL10, CRP
47sb 20358044 598.8IL8, ALOX5, IL10, CRP, TNF, IFNG
48methotrexate44 49 119.8GGT1, ENO2, IL1B, IL10, CRP, ADA
49nitric oxide44 11 249.0CCL3, TLR2, IFNG, MBL2, TNF, ENO2
50vegf446.1NPPA, POMC, TNF, MBL2, IFNG, TLR2

GO Terms for genes affiliated with Tuberculous Meningitis

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16Gene Ontology
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Cellular components related to Tuberculous Meningitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.3ADA, TNF, IFNG, TLR2
2extracellular regionGO:0055767.0TNF, MBL2, IFNG, CCL3, NPPA, CRP
3extracellular spaceGO:0056156.6LYZ, CCL3, IFNG, MBL2, TNF, NPPA

Biological processes related to Tuberculous Meningitis according to GeneCards/GeneDecks:

(show all 39)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of cytokine secretion involved in immune responseGO:00274010.5IL10
2positive regulation of vitamin D biosynthetic processGO:06055710.2TNF, IFNG
3opsonizationGO:00822810.1MBL2, CRP
4positive regulation of MHC class II biosynthetic processGO:04534810.1IFNG, IL10
5negative regulation of interleukin-17 productionGO:03270010.1IFNG, TLR2
6receptor biosynthetic processGO:03280010.1IL10, TNF
7positive regulation of interleukin-6 biosynthetic processGO:04541010.1IFNG, IL1B
8sequestering of triglycerideGO:03073010.0IL1B, TNF
9positive regulation of heterotypic cell-cell adhesionGO:03411610.0IL1B, TNF
10positive regulation of fever generationGO:03162210.0IL1B, TNF
11embryonic digestive tract developmentGO:04856610.0ADA, IL8, TNF
12negative regulation of lipid storageGO:01088810.0TNF, CRP
13negative regulation of interleukin-12 productionGO:0326959.9IL10, TLR2
14positive regulation of cytokine secretionGO:0507159.9TLR2, TNF, IL10
15response to molecule of bacterial originGO:0022379.9IL8, IL10
16defense response to bacteriumGO:0427429.8LYZ, IL10, MBL2, IFNG
17positive regulation of NF-kappaB import into nucleusGO:0423469.8TLR2, TNF, IL1B
18positive regulation of calcidiol 1-monooxygenase activityGO:0605599.8IFNG, TNF, IL1B
19positive regulation of chemokine biosynthetic processGO:0450809.8IL1B, TNF, IFNG
20positive regulation of membrane protein ectodomain proteolysisGO:0510449.8IFNG, TNF, IL1B
21positive regulation of interleukin-6 productionGO:0327559.8TLR2, TNF, IL1B
22cellular response to lipopolysaccharideGO:0712229.7IFNG, IL10, IL8
23positive regulation of tumor necrosis factor productionGO:0327609.7IFNG, TLR2, CCL3
24defense response to Gram-positive bacteriumGO:0508309.7CRP, TNF, MBL2, TLR2
25cell activationGO:0017759.6CCL3, TNF
26positive regulation of nitric oxide biosynthetic processGO:0454299.6TLR2, IFNG, TNF, IL1B
27calcium-mediated signalingGO:0197229.5IL8, TNF, CCL3
28positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.4IL1B, IL10, TNF
29cellular response to organic cyclic compoundGO:0714079.4IL1B, TNF, CCL3
30negative regulation of growth of symbiont in hostGO:0441309.4IL10, TNF, MBL2, IFNG, TLR2
31protein kinase B signaling cascadeGO:0434919.4CCL3, TNF, IL1B
32regulation of I-kappaB kinase/NF-kappaB cascadeGO:0431229.4IL1B, TNF
33MAPK cascadeGO:0001659.4CCL3, TNF, IL1B
34regulation of insulin secretionGO:0507969.3IFNG, TNF, IL1B
35neutrophil chemotaxisGO:0305939.3CCL3, IFNG, IL8, IL1B
36lipopolysaccharide-mediated signaling pathwayGO:0316639.2IL1B, TNF, TLR2, CCL3
37cell-cell signalingGO:0072679.1CCL3, POMC, IL10, IL1B
38positive regulation of transcription from RNA polymerase II promoterGO:0459448.9TLR2, IFNG, TNF, POMC, IL10, IL1B
39inflammatory responseGO:0069548.1CCL3, TLR2, TNF, CRP, IL10, IL8

Molecular functions related to Tuberculous Meningitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.1IL1B, IL10, TNF, IFNG

Products for genes affiliated with Tuberculous Meningitis

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  • Antibodies
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Sources for Tuberculous Meningitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet