MCID: TBR012
MIFTS: 24

Tuberculous Uveitis malady

Summaries for Tuberculous Uveitis

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33MalaCards
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MalaCards: Tuberculous Uveitis is related to uveitis and tuberculosis. An important gene associated with Tuberculous Uveitis is IFNG (interferon, gamma), and among its related pathways are Spinal Cord Injury and 4-1BB Pathway. The compounds interferon gamma and taurine chloramine have been mentioned in the context of this disorder. Affiliated tissues include liver and skin.

Aliases & Classifications for Tuberculous Uveitis

Sources:
43NIH Rare Diseases, 61UMLS
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Aliases & Descriptions:

tuberculous uveitis 43 61


Related Diseases for Tuberculous Uveitis

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Tuberculous Uveitis:



Diseases related to tuberculous uveitis

Clinical Features for Tuberculous Uveitis

Drugs & Therapeutics for Tuberculous Uveitis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Tuberculous Uveitis

Drug clinical trials:

Search ClinicalTrials for Tuberculous Uveitis

Search NIH Clinical Center for Tuberculous Uveitis

Search CenterWatch for Tuberculous Uveitis

Genetic Tests for Tuberculous Uveitis

Anatomical Context for Tuberculous Uveitis

Sources:
33MalaCards
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MalaCards organs/tissues related to Tuberculous Uveitis:

33
Liver, Skin

Animal Models for Tuberculous Uveitis or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Tuberculous Uveitis

Sources:
51PubMed
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Articles related to Tuberculous Uveitis:

(show all 27)
idTitleAuthorsYear
1
Liver failure following antituberculosis (ATT) chemotherapy for presumed tuberculous uveitis. (24136572)
2014
2
Tuberculous uveitis. (23450761)
2013
3
Diagnosis and treatment of tuberculous uveitis in a low endemic setting. (23706496)
2013
4
Clinical application of an in-house ELISPOT assay in patients with suspicious tuberculous uveitis and no signs of active tuberculosis. (22344468)
2012
5
Uveitis with occult choroiditis due to Mycobacterium kansasii: limitations of interferon-gamma release assay (IGRA) tests (case report and mini-review on ocular non-tuberculous mycobacteria and IGRA cross-reactivity). (22661050)
2012
6
Hypopyon in the context of tuberculous uveitis. (22229955)
2012
7
Cytokine and CXC chemokine expression patterns in aqueous humor of patients with presumed tuberculous uveitis. (22583692)
2012
8
Presumed tuberculous uveitis: diagnosis, management, and outcome. (21293496)
2011
9
Tuberculous uveitis. (20375860)
2010
10
Tuberculous uveitis. (20438968)
2010
11
Tuberculous uveitis. (20141860)
2010
12
Diagnosis of tuberculous uveitis: clinical application of an interferon-gamma release assay. (19576501)
2009
13
Tuberculous uveitis. (20404986)
2009
14
Strengths and weaknesses of diagnostic tools for tuberculous uveitis. (19831571)
2009
15
Tuberculous uveitis, a resurgent and underdiagnosed disease. (17486298)
2009
16
Tuberculous uveitis at a referral center in southeastern Brazil. (18345453)
2008
17
Interferon-gamma release assays in the diagnosis of tuberculous uveitis. (18804561)
2008
18
Interferon-gamma assay in tuberculous uveitis. (18369081)
2008
19
Clinical and optical coherence tomographic findings and outcome of treatment in patients with presumed tuberculous uveitis. (18034214)
2008
20
Tuberculous uveitis after treatment with etanercept. (17364199)
2007
21
Tuberculous uveitis: distribution of Mycobacterium tuberculosis in the retinal pigment epithelium. (17159041)
2006
22
A Case of Tuberculous Uveitis Complicated by Myelodysplastic Syndrome. (11033161)
2000
23
An airman with tuberculous uveitis: case study. (11439726)
2000
24
The tuberculin skin test in the diagnosis of tuberculous uveitis. (6614107)
1983
25
Tuberculous uveitis. (6849367)
1983
26
The role of the isoniazid therapeutic test in tuberculous uveitis. (6890314)
1982
27
Isoniazid in tuberculous uveitis. (13137643)
1954

Genetic Variations for Tuberculous Uveitis

Expression for genes affiliated with Tuberculous Uveitis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Tuberculous Uveitis

Search GEO for disease gene expression data for Tuberculous Uveitis.

Pathways for genes affiliated with Tuberculous Uveitis

Sources:
38NCBI BioSystems Database, 52QIAGEN, 30KEGG, 12EMD Millipore, 54Reactome, 53R&D Systems
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Pathways related to Tuberculous Uveitis according to GeneCards/GeneDecks:

(show all 28)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0TNF
2
Hide members
9.1TNF, IFNG
39.1TNF, IFNG
49.1IFNG, TNF
59.1TNF, IFNG
6
Hide members
9.1TNF, IFNG
7
Development PDGF signaling via STATs and NF-kB
Hide members
9.1IFNG, TNF
89.1TNF, IFNG
9
Hide members
9.1TNF, IFNG
10
Hide members
9.1TNF, IFNG
11
Hide members
9.1TNF, IFNG
129.1IFNG, TNF
13
Hide members
9.1TNF, IFNG
149.1TNF, IFNG
159.1IFNG, TNF
169.1TNF, IFNG
179.1TNF, IFNG
189.1IFNG, TNF
199.1TNF, IFNG
209.1TNF, IFNG
21
Hide members
9.1IFNG, TNF
229.1TNF, IFNG
23
Transcription Role of VDR in regulation of genes involved in osteoporosis
Hide members
9.1TNF, IFNG
24
Immune response Bacterial infections in normal airways
9.1TNF, IFNG
25
Hide members
9.1IFNG, TNF
269.1IFNG, TNF
27
Hide members
9.1TNF, IFNG
28
Hide members
9.1TNF, IFNG

Compounds for genes affiliated with Tuberculous Uveitis

Sources:
45Novoseek, 11DrugBank, 50PharmGKB, 29IUPHAR, 60Tocris Bioscience, 2BitterDB, 24HMDB
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Compounds related to Tuberculous Uveitis according to GeneCards/GeneDecks:

(show all 41)
idCompoundScoreTop Affiliating Genes
1interferon gamma459.6TNF, IFNG
2taurine chloramine459.6IFNG, TNF
3vesnarinone459.6IFNG, TNF
4gold sodium thiomalate459.6TNF, IFNG
5natalizumab45 1110.5TNF, IFNG
6adalimumab45 50 1111.5IFNG, TNF
7il-12459.5TNF, IFNG
8staurosporin459.5IFNG, TNF
9indoleamine459.5IFNG, TNF
10imiquimod45 29 60 1112.5TNF, IFNG
11polymyxin b459.5IFNG, TNF
12okt3459.5TNF, IFNG
13gm-csf45 2910.5TNF, IFNG
14triptolide459.5TNF, IFNG
15budesonide45 50 1111.5IFNG, TNF
16parthenolide45 210.5IFNG, TNF
17fluticasone propionate45 50 60 1112.5TNF, IFNG
18polyinosinic-polycytidylic acid459.5IFNG, TNF
192,5-oligoadenylate459.5IFNG, TNF
20etanercept45 50 1111.5TNF, IFNG
21poly(i-c)459.5IFNG, TNF
22il 10459.5TNF, IFNG
23l-nmma459.5IFNG, TNF
24infliximab45 50 1111.5IFNG, TNF
25tarc459.4TNF, IFNG
26ivig459.4IFNG, TNF
27ccl345 2910.4TNF, IFNG
28melphalan45 1110.4TNF, IFNG
29neopterin459.4IFNG, TNF
3015-deoxy-delta-12,14-prostaglandin j2459.4TNF, IFNG
31thalidomide45 50 60 1112.4IFNG, TNF
32lactacystin459.4TNF, IFNG
33simvastatin45 50 60 29 11 2414.3TNF, IFNG
34herbimycin a45 6010.3IFNG, TNF
35ionomycin459.3TNF, IFNG
36tacrolimus45 50 1111.2IFNG, TNF
37calcitriol45 60 11 2412.2TNF, IFNG
38rantes459.1TNF, IFNG
39butyrate459.1TNF, IFNG
40indomethacin45 60 29 1112.0IFNG, TNF
41sb 20358045 609.8TNF, IFNG

GO Terms for genes affiliated with Tuberculous Uveitis

Sources:
16Gene Ontology
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Cellular components related to Tuberculous Uveitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.1TNF, IFNG

Biological processes related to Tuberculous Uveitis according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of vitamin D biosynthetic processGO:0605579.4TNF, IFNG
2positive regulation of calcidiol 1-monooxygenase activityGO:0605599.4TNF, IFNG
3positive regulation of chemokine biosynthetic processGO:0450809.4TNF, IFNG
4positive regulation of membrane protein ectodomain proteolysisGO:0510449.4IFNG, TNF
5negative regulation of growth of symbiont in hostGO:0441309.3TNF, IFNG
6positive regulation of osteoclast differentiationGO:0456729.3TNF, IFNG
7protein import into nucleus, translocationGO:0000609.3IFNG, TNF
8extrinsic apoptotic signaling pathwayGO:0971919.2TNF, IFNG
9positive regulation of nitric oxide biosynthetic processGO:0454299.2TNF, IFNG
10humoral immune responseGO:0069599.1IFNG, TNF
11response to drugGO:0424939.1TNF, IFNG
12regulation of insulin secretionGO:0507969.0TNF, IFNG
13response to virusGO:0096158.8TNF, IFNG

Molecular functions related to Tuberculous Uveitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.1TNF, IFNG

Products for genes affiliated with Tuberculous Uveitis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Tuberculous Uveitis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet