MCID: TBR012
MIFTS: 20

Tuberculous Uveitis malady

Summaries for Tuberculous Uveitis

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32MalaCards
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MalaCards: Tuberculous Uveitis is related to uveitis and tuberculosis. An important gene associated with Tuberculous Uveitis is IFNG (interferon, gamma), and among its related pathways are Spinal Cord Injury and 4-1BB Pathway. The compounds interferon gamma and taurine chloramine have been mentioned in the context of this disorder.

Aliases & Classifications for Tuberculous Uveitis

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42NIH Rare Diseases, 60UMLS
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Aliases & Descriptions:

tuberculous uveitis 42 60


Related Diseases for Tuberculous Uveitis

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Tuberculous Uveitis:



Diseases related to tuberculous uveitis

Clinical Features for Tuberculous Uveitis

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Drugs & Therapeutics for Tuberculous Uveitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Tuberculous Uveitis

Drug clinical trials:

Search ClinicalTrials for Tuberculous Uveitis

Search NIH Clinical Center for Tuberculous Uveitis

Search CenterWatch for Tuberculous Uveitis

Genetic Tests for Tuberculous Uveitis

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Anatomical Context for Tuberculous Uveitis

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Animal Models for Tuberculous Uveitis or affiliated genes

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Publications for Tuberculous Uveitis

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Genetic Variations for Tuberculous Uveitis

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Expression for genes affiliated with Tuberculous Uveitis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Tuberculous Uveitis

Search GEO for disease gene expression data for Tuberculous Uveitis.

Pathways for genes affiliated with Tuberculous Uveitis

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Sources:
37NCBI BioSystems Database, 51QIAGEN, 29KEGG, 12EMD Millipore, 53Reactome, 52R&D Systems
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Pathways related to Tuberculous Uveitis according to GeneCards/GeneDecks:

(show all 28)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0TNF
2
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9.1TNF, IFNG
39.1TNF, IFNG
49.1IFNG, TNF
59.1TNF, IFNG
6
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9.1TNF, IFNG
7
Development PDGF signaling via STATs and NF-kB
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9.1IFNG, TNF
89.1TNF, IFNG
9
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9.1TNF, IFNG
10
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9.1TNF, IFNG
11
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9.1TNF, IFNG
129.1IFNG, TNF
13
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9.1TNF, IFNG
149.1TNF, IFNG
159.1IFNG, TNF
169.1TNF, IFNG
179.1TNF, IFNG
189.1IFNG, TNF
199.1TNF, IFNG
209.1TNF, IFNG
21
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9.1IFNG, TNF
229.1TNF, IFNG
23
Transcription Role of VDR in regulation of genes involved in osteoporosis
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9.1TNF, IFNG
24
Immune response Bacterial infections in normal airways
9.1TNF, IFNG
25
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9.1IFNG, TNF
269.1IFNG, TNF
27
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9.1TNF, IFNG
28
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9.1TNF, IFNG

Compounds for genes affiliated with Tuberculous Uveitis

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Sources:
44Novoseek, 11DrugBank, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience, 2BitterDB, 24HMDB
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Compounds related to Tuberculous Uveitis according to GeneCards/GeneDecks:

(show all 41)
idCompoundScoreTop Affiliating Genes
1interferon gamma449.6TNF, IFNG
2taurine chloramine449.6IFNG, TNF
3vesnarinone449.6IFNG, TNF
4gold sodium thiomalate449.6TNF, IFNG
5natalizumab44 1110.5TNF, IFNG
6adalimumab44 49 1111.5IFNG, TNF
7il-12449.5TNF, IFNG
8staurosporin449.5IFNG, TNF
9indoleamine449.5IFNG, TNF
10imiquimod44 28 59 1112.5TNF, IFNG
11polymyxin b449.5IFNG, TNF
12okt3449.5TNF, IFNG
13gm-csf44 2810.5TNF, IFNG
14triptolide449.5TNF, IFNG
15budesonide44 49 1111.5IFNG, TNF
16parthenolide44 210.5IFNG, TNF
17fluticasone propionate44 49 59 1112.5TNF, IFNG
18polyinosinic-polycytidylic acid449.5IFNG, TNF
192,5-oligoadenylate449.5IFNG, TNF
20etanercept44 49 1111.5TNF, IFNG
21poly(i-c)449.5IFNG, TNF
22il 10449.5TNF, IFNG
23l-nmma449.5IFNG, TNF
24infliximab44 49 1111.5IFNG, TNF
25tarc449.4TNF, IFNG
26ivig449.4IFNG, TNF
27ccl344 2810.4TNF, IFNG
28melphalan44 1110.4TNF, IFNG
29neopterin449.4IFNG, TNF
3015-deoxy-delta-12,14-prostaglandin j2449.4TNF, IFNG
31thalidomide44 49 59 1112.4IFNG, TNF
32lactacystin449.4TNF, IFNG
33simvastatin44 49 59 28 11 2414.3TNF, IFNG
34herbimycin a44 5910.3IFNG, TNF
35ionomycin449.3TNF, IFNG
36tacrolimus44 49 1111.2IFNG, TNF
37calcitriol44 59 11 2412.2TNF, IFNG
38rantes449.1TNF, IFNG
39butyrate449.1TNF, IFNG
40indomethacin44 59 28 1112.0IFNG, TNF
41sb 20358044 599.8TNF, IFNG

GO Terms for genes affiliated with Tuberculous Uveitis

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Sources:
16Gene Ontology
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Cellular components related to Tuberculous Uveitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.1TNF, IFNG

Biological processes related to Tuberculous Uveitis according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of vitamin D biosynthetic processGO:0605579.4TNF, IFNG
2positive regulation of calcidiol 1-monooxygenase activityGO:0605599.4TNF, IFNG
3positive regulation of chemokine biosynthetic processGO:0450809.4TNF, IFNG
4positive regulation of membrane protein ectodomain proteolysisGO:0510449.4IFNG, TNF
5negative regulation of growth of symbiont in hostGO:0441309.3TNF, IFNG
6positive regulation of osteoclast differentiationGO:0456729.3TNF, IFNG
7protein import into nucleus, translocationGO:0000609.3IFNG, TNF
8extrinsic apoptotic signaling pathwayGO:0971919.2TNF, IFNG
9positive regulation of nitric oxide biosynthetic processGO:0454299.2TNF, IFNG
10humoral immune responseGO:0069599.1IFNG, TNF
11response to drugGO:0424939.1TNF, IFNG
12regulation of insulin secretionGO:0507969.0TNF, IFNG
13response to virusGO:0096158.8TNF, IFNG

Molecular functions related to Tuberculous Uveitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.1TNF, IFNG

Products for genes affiliated with Tuberculous Uveitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Tuberculous Uveitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet