MCID: TBR012
MIFTS: 31

Tuberculous Uveitis malady

Rare diseases category

Summaries for Tuberculous Uveitis

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34MalaCards
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MalaCards: Tuberculous Uveitis is related to uveitis and tuberculosis. An important gene associated with Tuberculous Uveitis is IFNG (interferon, gamma), and among its related pathways are 4-1BB Pathway and Leishmaniasis. The compounds interferon gamma and taurine chloramine have been mentioned in the context of this disorder. Affiliated tissues include testes, liver and skin.

Aliases & Classifications for Tuberculous Uveitis

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Sources:
44NIH Rare Diseases, 63UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Aliases & Descriptions:

tuberculous uveitis 44 63


Related Diseases for Tuberculous Uveitis

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Sources:
18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Tuberculous Uveitis:



Diseases related to tuberculous uveitis

Symptoms for Tuberculous Uveitis

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Drugs & Therapeutics for Tuberculous Uveitis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Tuberculous Uveitis

Drug clinical trials:

Search ClinicalTrials for Tuberculous Uveitis

Search NIH Clinical Center for Tuberculous Uveitis

Search CenterWatch for Tuberculous Uveitis

Genetic Tests for Tuberculous Uveitis

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Anatomical Context for Tuberculous Uveitis

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34MalaCards
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MalaCards organs/tissues related to Tuberculous Uveitis:

34
Testes, Liver, Skin

Animal Models for Tuberculous Uveitis or affiliated genes

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Publications for Tuberculous Uveitis

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53PubMed
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Articles related to Tuberculous Uveitis:

(show all 26)
idTitleAuthorsYear
1
Liver failure following antituberculosis (ATT) chemotherapy for presumed tuberculous uveitis. (24136572)
2014
2
Tuberculous uveitis. (23450761)
2013
3
Diagnosis and treatment of tuberculous uveitis in a low endemic setting. (23706496)
2013
4
Clinical application of an in-house ELISPOT assay in patients with suspicious tuberculous uveitis and no signs of active tuberculosis. (22344468)
2012
5
Hypopyon in the context of tuberculous uveitis. (22229955)
2012
6
Cytokine and CXC chemokine expression patterns in aqueous humor of patients with presumed tuberculous uveitis. (22583692)
2012
7
Presumed tuberculous uveitis: diagnosis, management, and outcome. (21293496)
2011
8
Tuberculous uveitis. (20375860)
2010
9
Tuberculous uveitis. (20438968)
2010
10
Tuberculous uveitis. (20141860)
2010
11
Diagnosis of tuberculous uveitis: clinical application of an interferon-gamma release assay. (19576501)
2009
12
Tuberculous uveitis. (20404986)
2009
13
Strengths and weaknesses of diagnostic tools for tuberculous uveitis. (19831571)
2009
14
Tuberculous uveitis, a resurgent and underdiagnosed disease. (17486298)
2009
15
Tuberculous uveitis at a referral center in southeastern Brazil. (18345453)
2008
16
Interferon-gamma release assays in the diagnosis of tuberculous uveitis. (18804561)
2008
17
Interferon-gamma assay in tuberculous uveitis. (18369081)
2008
18
Clinical and optical coherence tomographic findings and outcome of treatment in patients with presumed tuberculous uveitis. (18034214)
2008
19
Tuberculous uveitis after treatment with etanercept. (17364199)
2007
20
Tuberculous uveitis: distribution of Mycobacterium tuberculosis in the retinal pigment epithelium. (17159041)
2006
21
A Case of Tuberculous Uveitis Complicated by Myelodysplastic Syndrome. (11033161)
2000
22
An airman with tuberculous uveitis: case study. (11439726)
2000
23
The tuberculin skin test in the diagnosis of tuberculous uveitis. (6614107)
1983
24
Tuberculous uveitis. (6849367)
1983
25
The role of the isoniazid therapeutic test in tuberculous uveitis. (6890314)
1982
26
Isoniazid in tuberculous uveitis. (13137643)
1954

Variations for Tuberculous Uveitis

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Expression for genes affiliated with Tuberculous Uveitis

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Tuberculous Uveitis

Search GEO for disease gene expression data for Tuberculous Uveitis.

Pathways for genes affiliated with Tuberculous Uveitis

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Sources:
51PathCards, 54QIAGEN, 31KEGG, 61Thomson Reuters, 39NCBI BioSystems Database, 56Reactome, 55R&D Systems, 58SinoBiological
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Pathways related to Tuberculous Uveitis according to GeneCards/GeneDecks:

(show all 35)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.1TNF, IFNG
2
Show member pathways
9.1IFNG, TNF
39.1IFNG, TNF
49.1TNF, IFNG
5
Show member pathways
IL23-mediated signaling events39
Immune response IL 10 signaling pathway61
Angiopoietin receptor Tie2-mediated signaling39
Development PDGF signaling via STATs and NF kB61
Development Angiopoietin Tie2 signaling61
9.1IFNG, TNF
69.1IFNG, TNF
79.1TNF, IFNG
8
Show member pathways
BCR signaling pathway39
TCR Signaling Pathway39
9.1TNF, IFNG
9
Show member pathways
Immune response CD16 signaling in NK cells61
9.1IFNG, TNF
10
Show member pathways
9.1IFNG, TNF
11
Show member pathways
Proteasome Degradation39
Immune response Antigen presentation by MHC class I61
9.1IFNG, TNF
12
Show member pathways
9.1IFNG, TNF
13
Show member pathways
9.1IFNG, TNF
14
Show member pathways
9.1TNF, IFNG
15
Show member pathways
9.1IFNG, TNF
16
Show member pathways
Toll-like receptor signaling pathway39
Regulation of toll-like receptor signaling pathway39
9.1IFNG, TNF
179.1IFNG, TNF
18
Show member pathways
Immune response MIF in innate immunity response61
9.1TNF, IFNG
19
Show member pathways
9.1IFNG, TNF
209.1IFNG, TNF
219.1IFNG, TNF
229.1TNF, IFNG
239.1IFNG, TNF
24
Show member pathways
9.1IFNG, TNF
259.1IFNG, TNF
26
Show member pathways
Ras signaling in the CD4+ TCR pathway39
9.1TNF, IFNG
279.1TNF, IFNG
28
Show member pathways
thioredoxin pathway39
9.1IFNG, TNF
29
Show member pathways
Transcription NF kB signaling pathway61
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response61
9.1IFNG, TNF
309.1IFNG, TNF
31
Show member pathways
9.1TNF, IFNG
329.1IFNG, TNF
33
Show member pathways
Calcium signaling in the CD4+ TCR pathway39
9.1TNF, IFNG
34
Show member pathways
IL27-mediated signaling events39
9.1TNF, IFNG
359.1IFNG, TNF

Compounds for genes affiliated with Tuberculous Uveitis

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Sources:
46Novoseek, 12DrugBank, 52PharmGKB, 62Tocris Bioscience, 30IUPHAR, 3BitterDB, 25HMDB
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Compounds related to Tuberculous Uveitis according to GeneCards/GeneDecks:

(show top 50)    (show all 56)
idCompoundScoreTop Affiliating Genes
1interferon gamma469.6IFNG, TNF
2taurine chloramine469.6IFNG, TNF
3vesnarinone469.6IFNG, TNF
4gold sodium thiomalate469.6TNF, IFNG
5natalizumab46 1210.6IFNG, TNF
6il-12469.6IFNG, TNF
7adalimumab46 52 1211.6TNF, IFNG
8indoleamine469.6IFNG, TNF
9staurosporin469.6IFNG, TNF
10imiquimod46 62 30 1212.6TNF, IFNG
11polymyxin b469.6IFNG, TNF
12okt3469.6IFNG, TNF
13gm-csf46 3010.6TNF, IFNG
14triptolide469.5TNF, IFNG
15budesonide46 52 1211.5IFNG, TNF
16parthenolide46 310.5IFNG, TNF
17fluticasone propionate46 52 62 1212.5TNF, IFNG
18polyinosinic-polycytidylic acid469.5IFNG, TNF
192,5-oligoadenylate469.5IFNG, TNF
20rolipram46 62 3011.5TNF, IFNG
21etanercept46 52 1211.5IFNG, TNF
22poly(i-c)469.5IFNG, TNF
23il 10469.5TNF, IFNG
24mycophenolate mofetil46 52 1211.5TNF, IFNG
25l-nmma469.5IFNG, TNF
26tarc469.5TNF, IFNG
27infliximab46 52 1211.5TNF, IFNG
28glucosamine46 25 1211.5TNF, IFNG
29ivig469.5IFNG, TNF
30ccl346 3010.5TNF, IFNG
31pentoxifylline46 1210.5TNF, IFNG
32melphalan46 52 1211.5IFNG, TNF
33neopterin469.5TNF, IFNG
3415-deoxy-delta-12,14-prostaglandin j2469.4IFNG, TNF
35pdtc469.4IFNG, TNF
36thalidomide46 52 62 1212.4TNF, IFNG
37lactacystin469.4IFNG, TNF
38prednisolone46 30 1211.4IFNG, TNF
39hydrocortisone46 3 62 1212.4TNF, IFNG
40herbimycin a46 6210.4IFNG, TNF
41simvastatin46 52 62 30 25 1214.4IFNG, TNF
42endotoxin469.3TNF, IFNG
43ionomycin469.3IFNG, TNF
44tacrolimus46 52 1211.3IFNG, TNF
45calcitriol46 62 25 1212.2TNF, IFNG
46rantes469.2IFNG, TNF
47indomethacin46 30 62 1212.1IFNG, TNF
48histamine46 30 2511.1IFNG, TNF
49sb 20358046 6210.0TNF, IFNG
50butyrate468.8IFNG, TNF

GO Terms for genes affiliated with Tuberculous Uveitis

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Sources:
17Gene Ontology
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Cellular components related to Tuberculous Uveitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.1IFNG, TNF

Biological processes related to Tuberculous Uveitis according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of vitamin D biosynthetic processGO:0605579.4IFNG, TNF
2positive regulation of calcidiol 1-monooxygenase activityGO:0605599.4IFNG, TNF
3positive regulation of chemokine biosynthetic processGO:0450809.4IFNG, TNF
4positive regulation of membrane protein ectodomain proteolysisGO:0510449.4TNF, IFNG
5negative regulation of growth of symbiont in hostGO:0441309.4IFNG, TNF
6positive regulation of osteoclast differentiationGO:0456729.4IFNG, TNF
7protein import into nucleus, translocationGO:0000609.3IFNG, TNF
8positive regulation of nitric oxide biosynthetic processGO:0454299.3TNF, IFNG
9extrinsic apoptotic signaling pathwayGO:0971919.3IFNG, TNF
10humoral immune responseGO:0069599.2IFNG, TNF
11regulation of insulin secretionGO:0507969.2IFNG, TNF
12response to virusGO:0096159.1TNF, IFNG
13apoptotic processGO:0069159.1IFNG, TNF
14response to drugGO:0424939.0IFNG, TNF
15negative regulation of transcription from RNA polymerase II promoterGO:0001228.8IFNG, TNF

Molecular functions related to Tuberculous Uveitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.1IFNG, TNF

Products for genes affiliated with Tuberculous Uveitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Tuberculous Uveitis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet