MCID: TBR012
MIFTS: 31

Tuberculous Uveitis malady

Rare diseases category
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Summaries for Tuberculous Uveitis

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33MalaCards
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MalaCards: Tuberculous Uveitis is related to uveitis and tuberculosis. An important gene associated with Tuberculous Uveitis is IFNG (interferon, gamma), and among its related pathways are 4-1BB Pathway and Leishmaniasis. The compounds interferon gamma and taurine chloramine have been mentioned in the context of this disorder. Affiliated tissues include testes, liver and skin.

Aliases & Classifications for Tuberculous Uveitis

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43NIH Rare Diseases, 62UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Aliases & Descriptions:

tuberculous uveitis 43 62


Related Diseases for Tuberculous Uveitis

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Tuberculous Uveitis:



Diseases related to tuberculous uveitis

Symptoms for Tuberculous Uveitis

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Drugs & Therapeutics for Tuberculous Uveitis

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Tuberculous Uveitis

Search NIH Clinical Center for Tuberculous Uveitis

Genetic Tests for Tuberculous Uveitis

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Anatomical Context for Tuberculous Uveitis

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33MalaCards
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MalaCards organs/tissues related to Tuberculous Uveitis:

33
Testes, Liver, Skin

Animal Models for Tuberculous Uveitis or affiliated genes

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Publications for Tuberculous Uveitis

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52PubMed
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Articles related to Tuberculous Uveitis:

(show all 26)
idTitleAuthorsYear
1
Liver failure following antituberculosis (ATT) chemotherapy for presumed tuberculous uveitis. (24136572)
2014
2
Tuberculous uveitis. (23450761)
2013
3
Diagnosis and treatment of tuberculous uveitis in a low endemic setting. (23706496)
2013
4
Clinical application of an in-house ELISPOT assay in patients with suspicious tuberculous uveitis and no signs of active tuberculosis. (22344468)
2012
5
Hypopyon in the context of tuberculous uveitis. (22229955)
2012
6
Cytokine and CXC chemokine expression patterns in aqueous humor of patients with presumed tuberculous uveitis. (22583692)
2012
7
Presumed tuberculous uveitis: diagnosis, management, and outcome. (21293496)
2011
8
Tuberculous uveitis. (20375860)
2010
9
Tuberculous uveitis. (20438968)
2010
10
Tuberculous uveitis. (20141860)
2010
11
Diagnosis of tuberculous uveitis: clinical application of an interferon-gamma release assay. (19576501)
2009
12
Tuberculous uveitis. (20404986)
2009
13
Strengths and weaknesses of diagnostic tools for tuberculous uveitis. (19831571)
2009
14
Tuberculous uveitis, a resurgent and underdiagnosed disease. (17486298)
2009
15
Tuberculous uveitis at a referral center in southeastern Brazil. (18345453)
2008
16
Interferon-gamma release assays in the diagnosis of tuberculous uveitis. (18804561)
2008
17
Interferon-gamma assay in tuberculous uveitis. (18369081)
2008
18
Clinical and optical coherence tomographic findings and outcome of treatment in patients with presumed tuberculous uveitis. (18034214)
2008
19
Tuberculous uveitis after treatment with etanercept. (17364199)
2007
20
Tuberculous uveitis: distribution of Mycobacterium tuberculosis in the retinal pigment epithelium. (17159041)
2006
21
A Case of Tuberculous Uveitis Complicated by Myelodysplastic Syndrome. (11033161)
2000
22
An airman with tuberculous uveitis: case study. (11439726)
2000
23
The tuberculin skin test in the diagnosis of tuberculous uveitis. (6614107)
1983
24
Tuberculous uveitis. (6849367)
1983
25
The role of the isoniazid therapeutic test in tuberculous uveitis. (6890314)
1982
26
Isoniazid in tuberculous uveitis. (13137643)
1954

Variations for Tuberculous Uveitis

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Expression for genes affiliated with Tuberculous Uveitis

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Tuberculous Uveitis

Search GEO for disease gene expression data for Tuberculous Uveitis.

Pathways for genes affiliated with Tuberculous Uveitis

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Sources:
50PathCards, 53QIAGEN, 30KEGG, 60Thomson Reuters, 38NCBI BioSystems Database, 55Reactome, 54R&D Systems, 57SinoBiological
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Pathways related to Tuberculous Uveitis according to GeneCards/GeneDecks:

(show all 35)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.1TNF, IFNG
2
Show member pathways
9.1IFNG, TNF
39.1IFNG, TNF
49.1TNF, IFNG
5
Show member pathways
IL23-mediated signaling events38
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling38
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
9.1IFNG, TNF
69.1IFNG, TNF
79.1TNF, IFNG
8
Show member pathways
BCR signaling pathway38
TCR Signaling Pathway38
9.1TNF, IFNG
9
Show member pathways
Immune response CD16 signaling in NK cells60
9.1IFNG, TNF
10
Show member pathways
9.1IFNG, TNF
11
Show member pathways
Proteasome Degradation38
Immune response Antigen presentation by MHC class I60
9.1IFNG, TNF
12
Show member pathways
9.1IFNG, TNF
13
Show member pathways
9.1IFNG, TNF
14
Show member pathways
9.1TNF, IFNG
15
Show member pathways
9.1IFNG, TNF
16
Show member pathways
Toll-like receptor signaling pathway38
Regulation of toll-like receptor signaling pathway38
9.1IFNG, TNF
179.1IFNG, TNF
18
Show member pathways
Immune response MIF in innate immunity response60
9.1TNF, IFNG
19
Show member pathways
9.1IFNG, TNF
209.1IFNG, TNF
219.1IFNG, TNF
229.1TNF, IFNG
239.1IFNG, TNF
24
Show member pathways
9.1IFNG, TNF
259.1IFNG, TNF
26
Show member pathways
Ras signaling in the CD4+ TCR pathway38
9.1TNF, IFNG
279.1TNF, IFNG
28
Show member pathways
thioredoxin pathway38
9.1IFNG, TNF
29
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
9.1IFNG, TNF
309.1IFNG, TNF
31
Show member pathways
9.1TNF, IFNG
329.1IFNG, TNF
33
Show member pathways
Calcium signaling in the CD4+ TCR pathway38
9.1TNF, IFNG
34
Show member pathways
IL27-mediated signaling events38
9.1TNF, IFNG
359.1IFNG, TNF

Compounds for genes affiliated with Tuberculous Uveitis

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Sources:
45Novoseek, 11DrugBank, 51PharmGKB, 61Tocris Bioscience, 29IUPHAR, 3BitterDB, 24HMDB
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Compounds related to Tuberculous Uveitis according to GeneCards/GeneDecks:

(show top 50)    (show all 56)
idCompoundScoreTop Affiliating Genes
1interferon gamma459.6IFNG, TNF
2taurine chloramine459.6IFNG, TNF
3vesnarinone459.6IFNG, TNF
4gold sodium thiomalate459.6TNF, IFNG
5natalizumab45 1110.6IFNG, TNF
6il-12459.6IFNG, TNF
7adalimumab45 51 1111.6TNF, IFNG
8indoleamine459.6IFNG, TNF
9staurosporin459.6IFNG, TNF
10imiquimod45 61 29 1112.6TNF, IFNG
11polymyxin b459.6IFNG, TNF
12okt3459.6IFNG, TNF
13gm-csf45 2910.6TNF, IFNG
14triptolide459.5TNF, IFNG
15budesonide45 51 1111.5IFNG, TNF
16parthenolide45 310.5IFNG, TNF
17fluticasone propionate45 51 61 1112.5TNF, IFNG
18polyinosinic-polycytidylic acid459.5IFNG, TNF
192,5-oligoadenylate459.5IFNG, TNF
20rolipram45 61 2911.5TNF, IFNG
21etanercept45 51 1111.5IFNG, TNF
22poly(i-c)459.5IFNG, TNF
23il 10459.5TNF, IFNG
24mycophenolate mofetil45 51 1111.5TNF, IFNG
25l-nmma459.5IFNG, TNF
26tarc459.5TNF, IFNG
27infliximab45 51 1111.5TNF, IFNG
28glucosamine45 24 1111.5TNF, IFNG
29ivig459.5IFNG, TNF
30ccl345 2910.5TNF, IFNG
31pentoxifylline45 1110.5TNF, IFNG
32melphalan45 51 1111.5IFNG, TNF
33neopterin459.5TNF, IFNG
3415-deoxy-delta-12,14-prostaglandin j2459.4IFNG, TNF
35pdtc459.4IFNG, TNF
36thalidomide45 51 61 1112.4TNF, IFNG
37lactacystin459.4IFNG, TNF
38prednisolone45 29 1111.4IFNG, TNF
39hydrocortisone45 3 61 1112.4TNF, IFNG
40herbimycin a45 6110.4IFNG, TNF
41simvastatin45 51 61 29 24 1114.4IFNG, TNF
42endotoxin459.3TNF, IFNG
43ionomycin459.3IFNG, TNF
44tacrolimus45 51 1111.3IFNG, TNF
45calcitriol45 61 24 1112.2TNF, IFNG
46rantes459.2IFNG, TNF
47indomethacin45 29 61 1112.1IFNG, TNF
48histamine45 29 2411.1IFNG, TNF
49sb 20358045 6110.0TNF, IFNG
50butyrate458.8IFNG, TNF

GO Terms for genes affiliated with Tuberculous Uveitis

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16Gene Ontology
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Cellular components related to Tuberculous Uveitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.1IFNG, TNF

Biological processes related to Tuberculous Uveitis according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of vitamin D biosynthetic processGO:0605579.4IFNG, TNF
2positive regulation of calcidiol 1-monooxygenase activityGO:0605599.4IFNG, TNF
3positive regulation of chemokine biosynthetic processGO:0450809.4IFNG, TNF
4positive regulation of membrane protein ectodomain proteolysisGO:0510449.4TNF, IFNG
5negative regulation of growth of symbiont in hostGO:0441309.4IFNG, TNF
6positive regulation of osteoclast differentiationGO:0456729.4IFNG, TNF
7protein import into nucleus, translocationGO:0000609.3IFNG, TNF
8positive regulation of nitric oxide biosynthetic processGO:0454299.3TNF, IFNG
9extrinsic apoptotic signaling pathwayGO:0971919.3IFNG, TNF
10humoral immune responseGO:0069599.2IFNG, TNF
11regulation of insulin secretionGO:0507969.2IFNG, TNF
12response to virusGO:0096159.1TNF, IFNG
13apoptotic processGO:0069159.1IFNG, TNF
14response to drugGO:0424939.0IFNG, TNF
15negative regulation of transcription from RNA polymerase II promoterGO:0001228.8IFNG, TNF

Molecular functions related to Tuberculous Uveitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.1IFNG, TNF

Products for genes affiliated with Tuberculous Uveitis

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Sources for Tuberculous Uveitis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet