MCID: TBR012
MIFTS: 26

Tuberculous Uveitis malady

Rare diseases category

Aliases & Classifications for Tuberculous Uveitis

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Aliases & Descriptions for Tuberculous Uveitis:

Name: Tuberculous Uveitis 42 61


Classifications:



Summaries for Tuberculous Uveitis

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MalaCards based summary: Tuberculous Uveitis is related to uveitis and tuberculosis. An important gene associated with Tuberculous Uveitis is IFNG (interferon, gamma), and among its related pathways are Colorectal Cancer Metastasis and Leishmaniasis. The compounds interferon gamma and vesnarinone have been mentioned in the context of this disorder. Affiliated tissues include testes, skin and liver.

Related Diseases for Tuberculous Uveitis

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Graphical network of the top 20 diseases related to Tuberculous Uveitis:



Diseases related to tuberculous uveitis

Symptoms for Tuberculous Uveitis

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Drugs & Therapeutics for Tuberculous Uveitis

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Drug clinical trials:

Search ClinicalTrials for Tuberculous Uveitis

Search NIH Clinical Center for Tuberculous Uveitis

Genetic Tests for Tuberculous Uveitis

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Anatomical Context for Tuberculous Uveitis

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MalaCards organs/tissues related to Tuberculous Uveitis:

31
Testes, Skin, Liver

Animal Models for Tuberculous Uveitis or affiliated genes

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Publications for Tuberculous Uveitis

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Articles related to Tuberculous Uveitis:

(show all 30)
idTitleAuthorsYear
1
Cost-effectiveness of alternative strategies for interferon-I^ release assays and tuberculin skin test in tuberculous uveitis. (25573149)
2015
2
Tuberculous uveitis. (25615806)
2015
3
Prospective head-to-head study comparing 2 commercial interferon gamma release assays for the diagnosis of tuberculous uveitis. (24508163)
2014
4
Liver failure following antituberculosis (ATT) chemotherapy for presumed tuberculous uveitis. (24136572)
2014
5
Tuberculous uveitis in China. (24479692)
2014
6
Tuberculous uveitis. (23450761)
2013
7
Diagnosis and treatment of tuberculous uveitis in a low endemic setting. (23706496)
2013
8
Clinical application of an in-house ELISPOT assay in patients with suspicious tuberculous uveitis and no signs of active tuberculosis. (22344468)
2012
9
Hypopyon in the context of tuberculous uveitis. (22229955)
2012
10
Cytokine and CXC chemokine expression patterns in aqueous humor of patients with presumed tuberculous uveitis. (22583692)
2012
11
Presumed tuberculous uveitis: diagnosis, management, and outcome. (21293496)
2011
12
Tuberculous uveitis. (20375860)
2010
13
Tuberculous uveitis. (20438968)
2010
14
Tuberculous uveitis. (20141860)
2010
15
Diagnosis of tuberculous uveitis: clinical application of an interferon-gamma release assay. (19576501)
2009
16
Tuberculous uveitis. (20404986)
2009
17
Strengths and weaknesses of diagnostic tools for tuberculous uveitis. (19831571)
2009
18
Tuberculous uveitis, a resurgent and underdiagnosed disease. (17486298)
2009
19
Tuberculous uveitis at a referral center in southeastern Brazil. (18345453)
2008
20
Interferon-gamma release assays in the diagnosis of tuberculous uveitis. (18804561)
2008
21
Interferon-gamma assay in tuberculous uveitis. (18369081)
2008
22
Clinical and optical coherence tomographic findings and outcome of treatment in patients with presumed tuberculous uveitis. (18034214)
2008
23
Tuberculous uveitis after treatment with etanercept. (17364199)
2007
24
Tuberculous uveitis: distribution of Mycobacterium tuberculosis in the retinal pigment epithelium. (17159041)
2006
25
A Case of Tuberculous Uveitis Complicated by Myelodysplastic Syndrome. (11033161)
2000
26
An airman with tuberculous uveitis: case study. (11439726)
2000
27
The tuberculin skin test in the diagnosis of tuberculous uveitis. (6614107)
1983
28
Tuberculous uveitis. (6849367)
1983
29
The role of the isoniazid therapeutic test in tuberculous uveitis. (6890314)
1982
30
Isoniazid in tuberculous uveitis. (13137643)
1954

Variations for Tuberculous Uveitis

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Expression for genes affiliated with Tuberculous Uveitis

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Search GEO for disease gene expression data for Tuberculous Uveitis.

Pathways for genes affiliated with Tuberculous Uveitis

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Pathways related to Tuberculous Uveitis according to GeneCards Suite gene sharing:

(show all 35)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1TNF, IFNG
2
Show member pathways
9.1TNF, IFNG
39.1IFNG, TNF
4
Show member pathways
9.1TNF, IFNG
5
Show member pathways
IL23-mediated signaling events36
Immune response IL 10 signaling pathway59
Angiopoietin receptor Tie2-mediated signaling36
Development PDGF signaling via STATs and NF kB59
Development Angiopoietin Tie2 signaling59
9.1TNF, IFNG
69.1TNF, IFNG
79.1IFNG, TNF
8
Show member pathways
BCR signaling pathway36
TCR Signaling Pathway36
9.1TNF, IFNG
9
Show member pathways
Immune response CD16 signaling in NK cells59
9.1TNF, IFNG
10
Show member pathways
9.1IFNG, TNF
11
Show member pathways
Proteasome Degradation36
Immune response Antigen presentation by MHC class I59
9.1IFNG, TNF
12
Show member pathways
9.1TNF, IFNG
13
Show member pathways
9.1IFNG, TNF
14
Show member pathways
9.1IFNG, TNF
15
Show member pathways
9.1TNF, IFNG
16
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
9.1IFNG, TNF
179.1TNF, IFNG
18
Show member pathways
Immune response MIF in innate immunity response59
9.1IFNG, TNF
19
Show member pathways
9.1IFNG, TNF
209.1IFNG, TNF
219.1IFNG, TNF
229.1IFNG, TNF
239.1TNF, IFNG
24
Show member pathways
9.1IFNG, TNF
259.1IFNG, TNF
26
Show member pathways
Ras signaling in the CD4+ TCR pathway36
9.1IFNG, TNF
27
Show member pathways
Calcium signaling in the CD4+ TCR pathway36
9.1IFNG, TNF
28
Show member pathways
thioredoxin pathway36
9.1TNF, IFNG
29
Show member pathways
Transcription NF kB signaling pathway59
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response59
9.1TNF, IFNG
309.1IFNG, TNF
31
Show member pathways
9.1TNF, IFNG
329.1IFNG, TNF
339.1IFNG, TNF
34
Show member pathways
IL27-mediated signaling events36
9.1IFNG, TNF
359.1IFNG, TNF

Compounds for genes affiliated with Tuberculous Uveitis

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Compounds related to Tuberculous Uveitis according to GeneCards Suite gene sharing:

(show top 50)    (show all 56)
idCompoundScoreTop Affiliating Genes
1interferon gamma449.6IFNG, TNF
2vesnarinone449.6IFNG, TNF
3taurine chloramine449.6TNF, IFNG
4gold sodium thiomalate449.6IFNG, TNF
5natalizumab44 1110.6IFNG, TNF
6il-12449.6IFNG, TNF
7adalimumab44 50 1111.6IFNG, TNF
8indoleamine449.6TNF, IFNG
9staurosporin449.6TNF, IFNG
10imiquimod44 60 28 1112.6IFNG, TNF
11polymyxin b449.6TNF, IFNG
12okt3449.6IFNG, TNF
13gm-csf44 2810.6IFNG, TNF
14triptolide449.5IFNG, TNF
15budesonide44 50 1111.5TNF, IFNG
16parthenolide44 110.5TNF, IFNG
17fluticasone propionate44 50 60 1112.5IFNG, TNF
18polyinosinic-polycytidylic acid449.5IFNG, TNF
192,5-oligoadenylate449.5TNF, IFNG
20rolipram44 60 2811.5IFNG, TNF
21etanercept44 50 1111.5TNF, IFNG
22poly(i-c)449.5IFNG, TNF
23mycophenolate mofetil44 50 1111.5IFNG, TNF
24il 10449.5IFNG, TNF
25l-nmma449.5IFNG, TNF
26glucosamine44 24 1111.5TNF, IFNG
27infliximab44 50 1111.5IFNG, TNF
28tarc449.5IFNG, TNF
29ivig449.5TNF, IFNG
30pentoxifylline44 1110.5TNF, IFNG
31ccl344 2810.5TNF, IFNG
32melphalan44 50 1111.5TNF, IFNG
33neopterin449.5IFNG, TNF
3415-deoxy-delta-12,14-prostaglandin j2449.4TNF, IFNG
35pdtc449.4TNF, IFNG
36thalidomide44 50 60 1112.4TNF, IFNG
37lactacystin449.4TNF, IFNG
38prednisolone44 28 1111.4TNF, IFNG
39hydrocortisone44 1 60 1112.4TNF, IFNG
40herbimycin a44 6010.4IFNG, TNF
41simvastatin44 50 60 28 24 1114.4TNF, IFNG
42endotoxin449.3IFNG, TNF
43ionomycin449.3TNF, IFNG
44tacrolimus44 50 1111.3IFNG, TNF
45calcitriol44 60 24 1112.2IFNG, TNF
46rantes449.2TNF, IFNG
47indomethacin44 28 60 1112.1TNF, IFNG
48histamine44 28 2411.1IFNG, TNF
49sb 20358044 6010.0IFNG, TNF
50butyrate448.8TNF, IFNG

GO Terms for genes affiliated with Tuberculous Uveitis

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Cellular components related to Tuberculous Uveitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098979.1IFNG, TNF

Biological processes related to Tuberculous Uveitis according to GeneCards Suite gene sharing:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of vitamin D biosynthetic processGO:00605579.4IFNG, TNF
2positive regulation of calcidiol 1-monooxygenase activityGO:00605599.4IFNG, TNF
3positive regulation of chemokine biosynthetic processGO:00450809.4IFNG, TNF
4positive regulation of membrane protein ectodomain proteolysisGO:00510449.4TNF, IFNG
5negative regulation of growth of symbiont in hostGO:00441309.4IFNG, TNF
6positive regulation of osteoclast differentiationGO:00456729.4IFNG, TNF
7protein import into nucleus, translocationGO:00000609.3IFNG, TNF
8positive regulation of nitric oxide biosynthetic processGO:00454299.3TNF, IFNG
9extrinsic apoptotic signaling pathwayGO:00971919.3IFNG, TNF
10humoral immune responseGO:00069599.2IFNG, TNF
11regulation of insulin secretionGO:00507969.2IFNG, TNF
12response to virusGO:00096159.1TNF, IFNG
13apoptotic processGO:00069159.1IFNG, TNF
14response to drugGO:00424939.0IFNG, TNF
15negative regulation of transcription from RNA polymerase II promoterGO:00001228.8IFNG, TNF

Molecular functions related to Tuberculous Uveitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051259.1IFNG, TNF

Sources for Tuberculous Uveitis

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet