MCID: TBR012
MIFTS: 31

Tuberculous Uveitis malady

Rare diseases category
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Summaries for Tuberculous Uveitis

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MalaCards based summary: Tuberculous Uveitis is related to uveitis and tuberculosis. An important gene associated with Tuberculous Uveitis is IFNG (interferon, gamma), and among its related pathways are 4-1BB Pathway and Leishmaniasis. The compounds interferon gamma and taurine chloramine have been mentioned in the context of this disorder. Affiliated tissues include testes, liver and skin.

Aliases & Classifications for Tuberculous Uveitis

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Tuberculous Uveitis, Aliases & Descriptions:

Name: Tuberculous Uveitis 42 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Related Diseases for Tuberculous Uveitis

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Graphical network of the top 20 diseases related to Tuberculous Uveitis:



Diseases related to tuberculous uveitis

Symptoms for Tuberculous Uveitis

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Drugs & Therapeutics for Tuberculous Uveitis

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Drug clinical trials:

Search ClinicalTrials for Tuberculous Uveitis

Search NIH Clinical Center for Tuberculous Uveitis

Genetic Tests for Tuberculous Uveitis

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Anatomical Context for Tuberculous Uveitis

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MalaCards organs/tissues related to Tuberculous Uveitis:

32
Testes, Liver, Skin

Animal Models for Tuberculous Uveitis or affiliated genes

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Publications for Tuberculous Uveitis

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Articles related to Tuberculous Uveitis:

(show all 28)
idTitleAuthorsYear
1
Prospective head-to-head study comparing 2 commercial interferon gamma release assays for the diagnosis of tuberculous uveitis. (24508163)
2014
2
Liver failure following antituberculosis (ATT) chemotherapy for presumed tuberculous uveitis. (24136572)
2014
3
Tuberculous uveitis in China. (24479692)
2014
4
Tuberculous uveitis. (23450761)
2013
5
Diagnosis and treatment of tuberculous uveitis in a low endemic setting. (23706496)
2013
6
Clinical application of an in-house ELISPOT assay in patients with suspicious tuberculous uveitis and no signs of active tuberculosis. (22344468)
2012
7
Hypopyon in the context of tuberculous uveitis. (22229955)
2012
8
Cytokine and CXC chemokine expression patterns in aqueous humor of patients with presumed tuberculous uveitis. (22583692)
2012
9
Presumed tuberculous uveitis: diagnosis, management, and outcome. (21293496)
2011
10
Tuberculous uveitis. (20375860)
2010
11
Tuberculous uveitis. (20438968)
2010
12
Tuberculous uveitis. (20141860)
2010
13
Diagnosis of tuberculous uveitis: clinical application of an interferon-gamma release assay. (19576501)
2009
14
Tuberculous uveitis. (20404986)
2009
15
Strengths and weaknesses of diagnostic tools for tuberculous uveitis. (19831571)
2009
16
Tuberculous uveitis, a resurgent and underdiagnosed disease. (17486298)
2009
17
Tuberculous uveitis at a referral center in southeastern Brazil. (18345453)
2008
18
Interferon-gamma release assays in the diagnosis of tuberculous uveitis. (18804561)
2008
19
Interferon-gamma assay in tuberculous uveitis. (18369081)
2008
20
Clinical and optical coherence tomographic findings and outcome of treatment in patients with presumed tuberculous uveitis. (18034214)
2008
21
Tuberculous uveitis after treatment with etanercept. (17364199)
2007
22
Tuberculous uveitis: distribution of Mycobacterium tuberculosis in the retinal pigment epithelium. (17159041)
2006
23
A Case of Tuberculous Uveitis Complicated by Myelodysplastic Syndrome. (11033161)
2000
24
An airman with tuberculous uveitis: case study. (11439726)
2000
25
The tuberculin skin test in the diagnosis of tuberculous uveitis. (6614107)
1983
26
Tuberculous uveitis. (6849367)
1983
27
The role of the isoniazid therapeutic test in tuberculous uveitis. (6890314)
1982
28
Isoniazid in tuberculous uveitis. (13137643)
1954

Variations for Tuberculous Uveitis

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Expression for genes affiliated with Tuberculous Uveitis

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Expression patterns in normal tissues for genes affiliated with Tuberculous Uveitis

Search GEO for disease gene expression data for Tuberculous Uveitis.

Pathways for genes affiliated with Tuberculous Uveitis

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Pathways related to Tuberculous Uveitis according to GeneCards/GeneDecks:

(show all 35)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.1TNF, IFNG
2
Show member pathways
9.1IFNG, TNF
39.1IFNG, TNF
49.1TNF, IFNG
5
Show member pathways
IL23-mediated signaling events37
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling37
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
9.1IFNG, TNF
69.1IFNG, TNF
79.1TNF, IFNG
8
Show member pathways
BCR signaling pathway37
TCR Signaling Pathway37
9.1TNF, IFNG
9
Show member pathways
Immune response CD16 signaling in NK cells60
9.1IFNG, TNF
10
Show member pathways
9.1IFNG, TNF
11
Show member pathways
Proteasome Degradation37
Immune response Antigen presentation by MHC class I60
9.1IFNG, TNF
12
Show member pathways
9.1IFNG, TNF
13
Show member pathways
9.1IFNG, TNF
14
Show member pathways
9.1TNF, IFNG
15
Show member pathways
9.1IFNG, TNF
16
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
9.1IFNG, TNF
179.1IFNG, TNF
18
Show member pathways
Immune response MIF in innate immunity response60
9.1TNF, IFNG
19
Show member pathways
9.1IFNG, TNF
209.1IFNG, TNF
219.1IFNG, TNF
229.1TNF, IFNG
239.1IFNG, TNF
24
Show member pathways
9.1IFNG, TNF
259.1IFNG, TNF
26
Show member pathways
Ras signaling in the CD4+ TCR pathway37
9.1TNF, IFNG
279.1TNF, IFNG
28
Show member pathways
thioredoxin pathway37
9.1IFNG, TNF
29
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
9.1IFNG, TNF
309.1IFNG, TNF
31
Show member pathways
9.1TNF, IFNG
329.1IFNG, TNF
33
Show member pathways
Calcium signaling in the CD4+ TCR pathway37
9.1TNF, IFNG
34
Show member pathways
IL27-mediated signaling events37
9.1TNF, IFNG
359.1IFNG, TNF

Compounds for genes affiliated with Tuberculous Uveitis

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Compounds related to Tuberculous Uveitis according to GeneCards/GeneDecks:

(show top 50)    (show all 56)
idCompoundScoreTop Affiliating Genes
1interferon gamma449.6IFNG, TNF
2taurine chloramine449.6IFNG, TNF
3vesnarinone449.6IFNG, TNF
4gold sodium thiomalate449.6TNF, IFNG
5natalizumab44 1110.6IFNG, TNF
6il-12449.6IFNG, TNF
7adalimumab44 50 1111.6TNF, IFNG
8indoleamine449.6IFNG, TNF
9staurosporin449.6IFNG, TNF
10imiquimod44 61 28 1112.6TNF, IFNG
11polymyxin b449.6IFNG, TNF
12okt3449.6IFNG, TNF
13gm-csf44 2810.6TNF, IFNG
14triptolide449.5TNF, IFNG
15budesonide44 50 1111.5IFNG, TNF
16parthenolide44 210.5IFNG, TNF
17fluticasone propionate44 50 61 1112.5TNF, IFNG
18polyinosinic-polycytidylic acid449.5IFNG, TNF
192,5-oligoadenylate449.5IFNG, TNF
20rolipram44 61 2811.5TNF, IFNG
21etanercept44 50 1111.5IFNG, TNF
22poly(i-c)449.5IFNG, TNF
23il 10449.5TNF, IFNG
24mycophenolate mofetil44 50 1111.5TNF, IFNG
25l-nmma449.5IFNG, TNF
26tarc449.5TNF, IFNG
27infliximab44 50 1111.5TNF, IFNG
28glucosamine44 24 1111.5TNF, IFNG
29ivig449.5IFNG, TNF
30ccl344 2810.5TNF, IFNG
31pentoxifylline44 1110.5TNF, IFNG
32melphalan44 50 1111.5IFNG, TNF
33neopterin449.5TNF, IFNG
3415-deoxy-delta-12,14-prostaglandin j2449.4IFNG, TNF
35pdtc449.4IFNG, TNF
36thalidomide44 50 61 1112.4TNF, IFNG
37lactacystin449.4IFNG, TNF
38prednisolone44 28 1111.4IFNG, TNF
39hydrocortisone44 2 61 1112.4TNF, IFNG
40herbimycin a44 6110.4IFNG, TNF
41simvastatin44 50 61 28 24 1114.4IFNG, TNF
42endotoxin449.3TNF, IFNG
43ionomycin449.3IFNG, TNF
44tacrolimus44 50 1111.3IFNG, TNF
45calcitriol44 61 24 1112.2TNF, IFNG
46rantes449.2IFNG, TNF
47indomethacin44 28 61 1112.1IFNG, TNF
48histamine44 28 2411.1IFNG, TNF
49sb 20358044 6110.0TNF, IFNG
50butyrate448.8IFNG, TNF

GO Terms for genes affiliated with Tuberculous Uveitis

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Cellular components related to Tuberculous Uveitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.1IFNG, TNF

Biological processes related to Tuberculous Uveitis according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of vitamin D biosynthetic processGO:0605579.4IFNG, TNF
2positive regulation of calcidiol 1-monooxygenase activityGO:0605599.4IFNG, TNF
3positive regulation of chemokine biosynthetic processGO:0450809.4IFNG, TNF
4positive regulation of membrane protein ectodomain proteolysisGO:0510449.4TNF, IFNG
5negative regulation of growth of symbiont in hostGO:0441309.4IFNG, TNF
6positive regulation of osteoclast differentiationGO:0456729.4IFNG, TNF
7protein import into nucleus, translocationGO:0000609.3IFNG, TNF
8positive regulation of nitric oxide biosynthetic processGO:0454299.3TNF, IFNG
9extrinsic apoptotic signaling pathwayGO:0971919.3IFNG, TNF
10humoral immune responseGO:0069599.2IFNG, TNF
11regulation of insulin secretionGO:0507969.2IFNG, TNF
12response to virusGO:0096159.1TNF, IFNG
13apoptotic processGO:0069159.1IFNG, TNF
14response to drugGO:0424939.0IFNG, TNF
15negative regulation of transcription from RNA polymerase II promoterGO:0001228.8IFNG, TNF

Molecular functions related to Tuberculous Uveitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.1IFNG, TNF

Products for genes affiliated with Tuberculous Uveitis

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  • Antibodies
  • Proteins
  • Lysates

Sources for Tuberculous Uveitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet