TINU
MCID: TBL013
MIFTS: 42

Tubulointerstitial Nephritis and Uveitis (TINU) malady

Rare diseases, Eye diseases, Nephrological diseases categories
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Summaries for Tubulointerstitial Nephritis and Uveitis

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47OMIM, 33MalaCards
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MalaCards: Tubulointerstitial Nephritis and Uveitis, also known as tubulointerstitial nephritis and uveitis syndrome, is related to uveitis and nephritis. An important gene associated with Tubulointerstitial Nephritis and Uveitis is HLA-DQA1 (major histocompatibility complex, class II, DQ alpha 1), and among its related pathways are TNF Signaling and Influenza A. The compounds dpa 1 and lapatinib have been mentioned in the context of this disorder. Affiliated tissues include eye, kidney and lung.

Description from OMIM:47 607665

Aliases & Classifications for Tubulointerstitial Nephritis and Uveitis

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43NIH Rare Diseases, 62UMLS, 49Orphanet, 47OMIM, 36MESH via Orphanet, 26ICD10 via Orphanet, 59SNOMED-CT via Orphanet, 63UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Eye diseases, Nephrological diseases


Aliases & Descriptions:

tubulointerstitial nephritis and uveitis 43 62
tubulointerstitial nephritis and uveitis syndrome 49 47
tinu syndrome 43 49
acute tubulointerstitial nephritis and uveitis syndrome 49
tinu 43


External Ids:

OMIM47 607665
MESH via Orphanet36 C536922
ICD10 via Orphanet26 N10
SNOMED-CT via Orphanet59 418839003
UMLS via Orphanet63 C1639520, C2609298

Related Diseases for Tubulointerstitial Nephritis and Uveitis

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17GeneCards, 18GeneDecks
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Diseases related to Tubulointerstitial Nephritis and Uveitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 41)
idRelated DiseaseScoreTop Affiliating Genes
1uveitis11.3
2nephritis11.3
3fanconi syndrome10.5
4neuroretinitis10.5
5choroiditis10.5
6hyperthyroidism10.5
7interstitial nephritis10.3
8ankylosing spondylitis10.3
9interstitial lung disease10.3
10panuveitis10.3
11retinitis10.3
12spondylitis10.3
13thyroiditis10.3
14multifocal choroiditis10.3
15anterior uveitis10.1
16narcolepsy10.1HLA-DRB1
17viral hepatitis10.0HLA-DRB1, HLA-DQA1
18multiple sclerosis 110.0HLA-DRB1, HLA-DQB1
19granulomatous hepatitis10.0
20posterior uveitis10.0
21chorioretinal scar10.0
22chorioretinitis10.0
23hepatitis10.0
24scleritis10.0
25pulmonary tuberculosis10.0HLA-DRB1, HLA-DQB1
26autoimmune hepatitis10.0HLA-DRB1, HLA-DQB1
27hepatitis b10.0HLA-DQB1, HLA-DRB1
28asthma10.0HLA-DRB1, HLA-DQA1
29hypersensitivity reaction type ii disease10.0HLA-DRB1, HLA-DQB1
30sarcoidosis10.0HLA-DQB1, HLA-DRB1
31celiac disease10.0HLA-DQA1, HLA-DQB1
32dilated cardiomyopathy10.0HLA-DRB1, HLA-DQB1
33systemic scleroderma10.0HLA-DRB1, HLA-DQB1
34tuberculosis10.0HLA-DQB1, HLA-DRB1
35juvenile rheumatoid arthritis9.9HLA-DRB1, HLA-DQA1, HLA-DQB1
36graves' disease9.9HLA-DQB1, HLA-DQA1, HLA-DRB1
37type 1 diabetes mellitus9.9HLA-DRB1, HLA-DQA1, HLA-DQB1
38schizophrenia9.9HLA-DRB1, HLA-DQB1
39systemic lupus erythematosus9.9HLA-DRB1, HLA-DQA1, HLA-DQB1
40multiple sclerosis9.9HLA-DQB1, HLA-DQA1, HLA-DRB1
41diabetes mellitus9.9HLA-DRB1, HLA-DQA1, HLA-DQB1

Graphical network of the top 20 diseases related to Tubulointerstitial Nephritis and Uveitis:



Diseases related to tubulointerstitial nephritis and uveitis

Symptoms for Tubulointerstitial Nephritis and Uveitis

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47OMIM
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Symptoms by clinical synopsis from OMIM:

607665

Clinical features from OMIM:

607665

Drugs & Therapeutics for Tubulointerstitial Nephritis and Uveitis

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Tubulointerstitial Nephritis and Uveitis

Search NIH Clinical Center for Tubulointerstitial Nephritis and Uveitis

Genetic Tests for Tubulointerstitial Nephritis and Uveitis

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Anatomical Context for Tubulointerstitial Nephritis and Uveitis

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33MalaCards
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MalaCards organs/tissues related to Tubulointerstitial Nephritis and Uveitis:

33
Eye, Kidney, Lung, Thyroid

Animal Models for Tubulointerstitial Nephritis and Uveitis or affiliated genes

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Publications for Tubulointerstitial Nephritis and Uveitis

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Sources:
52PubMed
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Articles related to Tubulointerstitial Nephritis and Uveitis:

(show top 50)    (show all 81)
idTitleAuthorsYear
1
Neuroretinitis: a rare feature of tubulointerstitial nephritis and uveitis syndrome. (23824660)
2013
2
HLA-DR, DQ Class II DNA Typing in Pediatric Panuveitis and Tubulointerstitial Nephritis and Uveitis (TINU). (24321473)
2013
3
A boy with IgA nephropathy complicated by tubulointerstitial nephritis and uveitis (TINU) syndrome. (24075025)
2013
4
Tubulointerstitial nephritis and uveitis syndrome in an older adult: a case report and review of the literature. (24117310)
2013
5
Moth-eaten appearance of tubulointerstitial nephritis and uveitis syndrome on (99m)technetium dimercaptosuccinic acid scintigraphy. (23092525)
2013
6
Two cases of subfoveal choroidal neovascularization with tubulointerstitial nephritis and uveitis syndrome. (23335312)
2013
7
Tubulointerstitial nephritis and uveitis syndrome in a twelve-year-old girl. (23691408)
2013
8
Tubulointerstitial nephritis and uveitis syndrome in children: a prospective multicenter study. (23511116)
2013
9
Excellent outcome of tubulointerstitial nephritis and uveitis: case report and five-year follow-up. (22681193)
2012
10
TINU (tubulointerstitial nephritis and uveitis) syndrome is not usually associated with IgG4 sclerosing disease. (22277743)
2012
11
A rare case of acute renal failure due to tubulointerstitial nephritis and uveitis syndrome successfully treated with steroid. (23560359)
2012
12
Tubulointerstitial nephritis and uveitis: report of a rare syndrome. (21189439)
2011
13
Tubulointerstitial nephritis and uveitis syndrome with transient hyperthyroidism in an elderly patient. (21823045)
2011
14
Recurrent tubulointerstitial nephritis and uveitis syndrome in a renal transplant recipient. (21673077)
2011
15
Tubulointerstitial nephritis and uveitis (TINU) syndrome caused by the Chinese herb "Goreisan". (18661195)
2009
16
Short course of cyclophosphamide therapy may reduce recurrence in patients with tubulointerstitial nephritis and uveitis syndrome. (19587511)
2009
17
A Case of Tubulointerstitial Nephritis and Uveitis (TINU) Syndrome with High ASLO Titer. (24179369)
2009
18
Syndrome of tubulointerstitial nephritis and uveitis. (19582990)
2009
19
Is tubulointerstitial nephritis and uveitis syndrome associated with IgG4-related systemic disease? (18199112)
2008
20
Tubulointerstitial nephritis and uveitis syndrome (TINU): a step forward to understanding an elusive oculorenal syndrome. (18272778)
2008
21
Recurrent and progressive nephritis in a patient with acute tubulointerstitial nephritis and uveitis syndrome. (18218320)
2008
22
Human leucocyte antigen DQ alpha heterodimers and human leucocyte antigen DR alleles in tubulointerstitial nephritis and uveitis syndrome. (19154326)
2008
23
Presence of autoantibodies against tubular and uveal cells in a patient with tubulointerstitial nephritis and uveitis (TINU) syndrome. (18156461)
2008
24
Tubulointerstitial nephritis and uveitis syndrome in a mother and her son. (18528711)
2008
25
Tubulointerstitial nephritis and uveitis syndrome. (18427256)
2008
26
Enhanced recognition, treatment, and prognosis of tubulointerstitial nephritis and uveitis syndrome. (17383731)
2007
27
Lymphoid interstitial lung disease in a patient with acute tubulointerstitial nephritis and uveitis: a new facet of a rare syndrome? (16564933)
2006
28
Elevation of serum Krebs von den Lunge-6 levels in patients with tubulointerstitial nephritis and uveitis syndrome. (17162148)
2006
29
Adult onset tubulointerstitial nephritis and uveitis syndrome. (16109092)
2005
30
A case of tubulointerstitial nephritis and uveitis syndrome with severe immunologic dysregulation. (16208535)
2005
31
Tubulointerstitial nephritis and uveitis syndrome (TINU syndrome) with unilateral neuroretinitis: a case report. (15309980)
2004
32
Tubulointerstitial nephritis and uveitis in monozygotic twin boys. (15206033)
2004
33
Strong associations between specific HLA-DQ and HLA-DR alleles and the tubulointerstitial nephritis and uveitis syndrome. (12556395)
2003
34
A case of adult-onset tubulointerstitial nephritis and uveitis ("TINU syndrome") associated with sacroileitis and Epstein-Barr virus infection with good spontaneous outcome. (12955704)
2003
35
Tubulointerstitial nephritis and uveitis syndrome: a diagnosis that should be considered by rheumatologists. (12594128)
2003
36
The tubulointerstitial nephritis and uveitis syndrome. (12052421)
2002
37
Tubulointerstitial nephritis and uveitis syndrome. (11698749)
2001
38
Tubulointerstitial nephritis and uveitis syndrome in two siblings. (11556736)
2001
39
The tubulointerstitial nephritis and uveitis syndrome. (11738428)
2001
40
Repeat renal biopsy in a girl with tubulointerstitial nephritis and uveitis syndrome. (11685594)
2001
41
Tubulointerstitial nephritis and uveitis syndrome with autoantibody directed to renal tubular cells. (11389273)
2001
42
Tubulointerstitial nephritis and uveitis with bilateral multifocal choroiditis. (10926997)
2000
43
Acute tubulointerstitial nephritis and uveitis with angiotensin-converting enzyme increase. (10529642)
1999
44
Tubulointerstitial nephritis and uveitis in children and adolescents. Four new cases and a review of the literature. (10412864)
1999
45
Tubulointerstitial nephritis and uveitis in association with Epstein-Barr virus infection. (10454786)
1999
46
Tubulointerstitial nephritis and uveitis: an immunological disorder? (7794717)
1995
47
Clinical and immune aspects of idiopathic acute tubulointerstitial nephritis and uveitis syndrome. (7503137)
1995
48
Tubulointerstitial nephritis and uveitis: association with suppressed cellular immunity. (8255514)
1993
49
Syndrome of tubulointerstitial nephritis and uveitis: is it worth considering it as a proper entity? (8367000)
1993
50
Primary tubulointerstitial nephritis and uveitis syndrome. (8148149)
1993

Variations for Tubulointerstitial Nephritis and Uveitis

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Expression for genes affiliated with Tubulointerstitial Nephritis and Uveitis

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Tubulointerstitial Nephritis and Uveitis

Search GEO for disease gene expression data for Tubulointerstitial Nephritis and Uveitis.

Pathways for genes affiliated with Tubulointerstitial Nephritis and Uveitis

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Sources:
50PathCards, 57SinoBiological, 54R&D Systems, 30KEGG, 53QIAGEN, 38NCBI BioSystems Database, 55Reactome, 60Thomson Reuters
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Pathways related to Tubulointerstitial Nephritis and Uveitis according to GeneCards/GeneDecks:

(show all 25)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.0HLA-DQA1, HLA-DQB1
2
Show member pathways
8.5HLA-DRB1, HLA-DQA1, HLA-DQB1
3
Show member pathways
8.5HLA-DRB1, HLA-DQA1, HLA-DQB1
4
Show member pathways
8.5HLA-DRB1, HLA-DQA1, HLA-DQB1
58.5HLA-DRB1, HLA-DQA1, HLA-DQB1
6
Show member pathways
8.5HLA-DRB1, HLA-DQA1, HLA-DQB1
7
Show member pathways
8.5HLA-DRB1, HLA-DQA1, HLA-DQB1
8
Show member pathways
8.5HLA-DRB1, HLA-DQA1, HLA-DQB1
9
Show member pathways
8.5HLA-DRB1, HLA-DQA1, HLA-DQB1
10
Show member pathways
8.5HLA-DRB1, HLA-DQA1, HLA-DQB1
11
Show member pathways
8.5HLA-DRB1, HLA-DQA1, HLA-DQB1
12
Show member pathways
Immune response IL 22 signaling pathway60
G protein signaling N RAS regulation pathway60
8.5HLA-DRB1, HLA-DQA1, HLA-DQB1
138.5HLA-DRB1, HLA-DQA1, HLA-DQB1
14
Show member pathways
8.5HLA-DRB1, HLA-DQA1, HLA-DQB1
158.5HLA-DRB1, HLA-DQA1, HLA-DQB1
16
Show member pathways
8.5HLA-DQB1, HLA-DQA1, HLA-DRB1
17
Show member pathways
8.5HLA-DQB1, HLA-DQA1, HLA-DRB1
188.5HLA-DQB1, HLA-DQA1, HLA-DRB1
198.5HLA-DQB1, HLA-DQA1, HLA-DRB1
208.5HLA-DQB1, HLA-DQA1, HLA-DRB1
21
Show member pathways
8.5HLA-DQB1, HLA-DQA1, HLA-DRB1
228.5HLA-DQB1, HLA-DQA1, HLA-DRB1
23
Show member pathways
Immune response T cell receptor signaling pathway60
Immune response CD28 signaling60
Immune response ICOS pathway in T helper cell60
8.5HLA-DQB1, HLA-DQA1, HLA-DRB1
248.5HLA-DQB1, HLA-DQA1, HLA-DRB1
25
Show member pathways
8.5HLA-DQB1, HLA-DQA1, HLA-DRB1

Compounds for genes affiliated with Tubulointerstitial Nephritis and Uveitis

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Sources:
45Novoseek, 51PharmGKB, 11DrugBank
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Compounds related to Tubulointerstitial Nephritis and Uveitis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1dpa 1459.3HLA-DRB1, HLA-DQA1
2lapatinib45 51 1111.2HLA-DRB1, HLA-DQA1
3aspartate459.0HLA-DQA1, HLA-DQB1
4oligonucleotide458.2HLA-DRB1, HLA-DQA1, HLA-DQB1

GO Terms for genes affiliated with Tubulointerstitial Nephritis and Uveitis

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16Gene Ontology
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Cellular components related to Tubulointerstitial Nephritis and Uveitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endosome membraneGO:0100089.0HLA-DQA1, HLA-DQB1
2MHC class II protein complexGO:0426138.7HLA-DRB1, HLA-DQA1, HLA-DQB1
3integral component of lumenal side of endoplasmic reticulum membraneGO:0715568.7HLA-DRB1, HLA-DQA1, HLA-DQB1
4clathrin-coated endocytic vesicle membraneGO:0306698.7HLA-DQB1, HLA-DQA1, HLA-DRB1
5transport vesicle membraneGO:0306588.7HLA-DRB1, HLA-DQA1, HLA-DQB1
6ER to Golgi transport vesicle membraneGO:0125078.6HLA-DQB1, HLA-DQA1, HLA-DRB1
7trans-Golgi network membraneGO:0325888.6HLA-DRB1, HLA-DQA1, HLA-DQB1
8endocytic vesicle membraneGO:0306668.5HLA-DRB1, HLA-DQA1, HLA-DQB1
9lysosomal membraneGO:0057658.4HLA-DQB1, HLA-DQA1, HLA-DRB1
10Golgi membraneGO:0001398.2HLA-DRB1, HLA-DQA1, HLA-DQB1

Biological processes related to Tubulointerstitial Nephritis and Uveitis according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1immunoglobulin production involved in immunoglobulin mediated immune responseGO:0023819.1HLA-DRB1, HLA-DQB1
2humoral immune response mediated by circulating immunoglobulinGO:0024559.0HLA-DRB1, HLA-DQB1
3interferon-gamma-mediated signaling pathwayGO:0603338.7HLA-DRB1, HLA-DQA1, HLA-DQB1
4T cell costimulationGO:0312958.7HLA-DQB1, HLA-DQA1, HLA-DRB1
5T cell receptor signaling pathwayGO:0508528.6HLA-DRB1, HLA-DQA1, HLA-DQB1
6antigen processing and presentation of exogenous peptide antigen via MHC class IIGO:0198868.6HLA-DQB1, HLA-DQA1, HLA-DRB1
7immune responseGO:0069558.5HLA-DRB1, HLA-DQA1, HLA-DQB1
8cytokine-mediated signaling pathwayGO:0192218.2HLA-DQB1, HLA-DQA1, HLA-DRB1

Molecular functions related to Tubulointerstitial Nephritis and Uveitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class II receptor activityGO:0323958.5HLA-DRB1, HLA-DQA1, HLA-DQB1

Products for genes affiliated with Tubulointerstitial Nephritis and Uveitis

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  • Antibodies
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Sources for Tubulointerstitial Nephritis and Uveitis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet