MCID: TBL013
MIFTS: 31

Tubulointerstitial Nephritis and Uveitis malady

Categories: Rare diseases, Eye diseases, Nephrological diseases

Aliases & Classifications for Tubulointerstitial Nephritis and Uveitis

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Sources:
45NIH Rare Diseases, 65UMLS, 51Orphanet, 24GTR, 66UMLS via Orphanet, 28ICD10 via Orphanet, 37MESH via Orphanet
See all MalaCards sources

Aliases & Descriptions for Tubulointerstitial Nephritis and Uveitis:

Name: Tubulointerstitial Nephritis and Uveitis 45 65
Tubulointerstitial Nephritis and Uveitis Syndrome 51 24
Tinu Syndrome 45 51
 
Acute Tubulointerstitial Nephritis and Uveitis Syndrome 51
Tinu 45

Classifications:



External Ids:

Orphanet51 91500
UMLS via Orphanet66 C1639520, C2609298
ICD10 via Orphanet28 N10
MESH via Orphanet37 C536922
UMLS65 C1843273

Summaries for Tubulointerstitial Nephritis and Uveitis

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Wikipedia:68 Tubulointerstitial nephritis and uveitis (TINU) is a rare medical condition in which there is uveitis... more...

MalaCards based summary: Tubulointerstitial Nephritis and Uveitis, also known as tubulointerstitial nephritis and uveitis syndrome, is related to rheumatoid arthritis and prostate cancer. An important gene associated with Tubulointerstitial Nephritis and Uveitis is HLA-DQB1 (Major Histocompatibility Complex, Class II, DQ Beta 1), and among its related pathways are Interferon gamma signaling and HTLV-I infection. Affiliated tissues include eye, kidney and smooth muscle.

Related Diseases for Tubulointerstitial Nephritis and Uveitis

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Graphical network of the top 20 diseases related to Tubulointerstitial Nephritis and Uveitis:



Diseases related to tubulointerstitial nephritis and uveitis

Symptoms for Tubulointerstitial Nephritis and Uveitis

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Drugs & Therapeutics for Tubulointerstitial Nephritis and Uveitis

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Tubulointerstitial Nephritis and Uveitis

Genetic Tests for Tubulointerstitial Nephritis and Uveitis

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Anatomical Context for Tubulointerstitial Nephritis and Uveitis

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MalaCards organs/tissues related to Tubulointerstitial Nephritis and Uveitis:

33
Eye, Kidney, Smooth muscle, Monocytes, Skin, B cells, Tongue

Animal Models for Tubulointerstitial Nephritis and Uveitis or affiliated genes

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Publications for Tubulointerstitial Nephritis and Uveitis

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Articles related to Tubulointerstitial Nephritis and Uveitis:

(show top 50)    (show all 92)
idTitleAuthorsYear
1
Relation of otosclerosis and osteoporosis: A bone mineral density study. (26656733)
2016
2
Novel oncogene and tumor suppressor mutations in KIT and PDGFRA wild type gastrointestinal stromal tumors revealed by next generation sequencing. (25427437)
2015
3
Von Willebrand factor is elevated in individuals infected with Sudan virus and is associated with adverse clinical outcomes. (25387000)
2015
4
Differential expression of cardiac uncoupling proteins 2 and 3 in response to myocardial ischemia-reperfusion in rats. (24434797)
2014
5
Tyrosine sulfation of chemokine receptor CCR2 enhances interactions with both monomeric and dimeric forms of the chemokine monocyte chemoattractant protein-1 (MCP-1). (23408426)
2013
6
Primary monophasic synovial sarcoma of the kidney: a case report and review of literature. (24137053)
2013
7
A comparison of VLSM and VBM in a cohort of patients with post-stroke aphasia. (24179735)
2012
8
Contribution of TMC6 and TMC8 (EVER1 and EVER2) variants to cervical cancer susceptibility. (21387292)
2012
9
Increased serum baseline tryptase levels and extensive skin involvement are predictors for the severity of mast cell activation episodes in children with mastocytosis. (22458675)
2012
10
Imatinib mesylate treatment for platelet-derived growth factor receptor alfa-positive choroid plexus carcinoma. (24765448)
2012
11
A rare association of fibromuscular dysplasia, renal agenesis, renal arteriovenous fistulae, and vertebral anomalies: expanding the V in VACTERL association. (23023878)
2012
12
Adenocarcinoma in situ and associated human papillomavirus type distribution observed in two clinical trials of a quadrivalent human papillomavirus vaccine. (20949623)
2011
13
Learning curve for robot-assisted laparoscopic radical prostatectomy for pathologic t2 disease. (20414407)
2010
14
Duodenal hypersensitivity to acid in patients with functional dyspepsia-pathogenesis and evaluation. (20383029)
2010
15
Monocyte CD147 is induced by advanced glycation end products and high glucose concentration: possible role in diabetic complications. (20810913)
2010
16
Plasma brain natriuretic peptide can be a biological marker to distinguish cardioembolic stroke from other stroke types in acute ischemic stroke. (19252345)
2009
17
Uptake of CCR7 and acquisition of migratory properties by human KIR+ NK cells interacting with monocyte-derived DC or EBV cell lines: regulation by KIR/HLA-class I interaction. (19749090)
2009
18
Epac is involved in cAMP-stimulated proglucagon expression and hormone production but not hormone secretion in pancreatic alpha- and intestinal L-cell lines. (18854429)
2009
19
Use of rituximab for refractory cytopenias associated with autoimmune lymphoproliferative syndrome (ALPS). (19214977)
2009
20
CD133+ anaplastic thyroid cancer cells initiate tumors in immunodeficient mice and are regulated by thyrotropin. (19404394)
2009
21
Grapefruit juice and its constituents augment colchicine intestinal absorption: potential hazardous interaction and the role of p-glycoprotein. (19048359)
2009
22
CXCR4 expression is elevated in glioblastoma multiforme and correlates with an increase in intensity and extent of peritumoral T2-weighted magnetic resonance imaging signal abnormalities. (18812968)
2008
23
Response to IL-1-receptor antagonist in a child with familial cold autoinflammatory syndrome. (17300660)
2007
24
Reach performance and postural adjustments during standing in children with severe spastic diplegia using dynamic ankle-foot orthoses. (17999010)
2007
25
Integration site selection by the Bacteroides conjugative transposon CTnBST. (17616597)
2007
26
Spondylometaphyseal dysplasia-Sedaghatian type associated with intra-partum cardiac arrhythmia and neonatal death. (18097914)
2007
27
P53 mutations in urinary bladder cancer patients from Central Poland. (17495352)
2007
28
COX-2 expression of ampullary carcinoma: correlation with different histotypes and clinicopathological parameters. (16906389)
2006
29
The actin-depolymerizing factor homology and charged/helical domains of drebrin and mAbp1 direct membrane binding and localization via distinct interactions with actin. (16452483)
2006
30
Interferon-gamma levels in familial Mediterranean fever. (15681246)
2005
31
Coupling of ER exit to microtubules through direct interaction of COPII with dynactin. (15580264)
2005
32
Organ preservation with interstitial radiation for base of tongue cancer. (12393990)
2002
33
Inhibition of PDGF-stimulated and matrix-mediated proliferation of human vascular smooth muscle cells by SPARC is independent of changes in cell shape or cyclin-dependent kinase inhibitors. (11835401)
2002
34
Surgically induced diffuse scleritis: comparison of incidence in phacoemulsification and conventional extracapsular cataract extraction. (12034697)
2002
35
From gene to disease; from SDHD, a defect in the respiratory chain, to paragangliomas and pheochromocytomas]. (12467161)
2002
36
Changes in oxygen-scavenging systems and membrane lipid peroxidation during maturation and ripening in blackberry. (11312904)
2001
37
Hemorrhagic fever with renal syndrome: first imported case of hantavirus infection in Taiwan. (8772056)
1996
38
Effect of early enalapril therapy on left ventricular function and structure in acute myocardial infarction. (7572651)
1995
39
Decreased frequency of interferon-gamma- and interleukin-2-producing cells in patients with atopic diseases measured at the single cell level. (7560664)
1995
40
Human acetyl-CoA carboxylase: characterization, molecular cloning, and evidence for two isoforms. (7732023)
1995
41
Hepatic and serologic toxicity of systemic interleukin-2 and/or interferon-alpha. Evidence of a risk-benefit advantage of subcutaneous therapy. (7910716)
1994
42
Koro in an industrial setting. (21743666)
1994
43
Allele frequencies of DNA markers genetically linked to Friedreich ataxia in the German population. (8103037)
1993
44
Topical indomethacin in the treatment of chronic cystoid macular edema. (1521802)
1992
45
Putative apolipoprotein receptor gene (LRP, A2MR) is not rearranged in either myxoid liposarcoma or lipomas with translocations in 12q13-14. (1318779)
1992
46
Medical therapy for gastroesophageal reflux disease. (1595772)
1992
47
Rare subependymal giant-cell astrocytoma in a neonate with tuberous sclerosis. (2124070)
1990
48
The influence of ethnicity, an atopic family history, and maternal ascariasis on cord blood serum IgE concentrations. (3403861)
1988
49
Hemifacial spasm and facial myokymia: electrophysiological findings. (3614256)
1987
50
Localized pigmented villonodular synovitis of the knee mimicking meniscal injury. (3801100)
1986

Variations for Tubulointerstitial Nephritis and Uveitis

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Expression for genes affiliated with Tubulointerstitial Nephritis and Uveitis

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Search GEO for disease gene expression data for Tubulointerstitial Nephritis and Uveitis.

Pathways for genes affiliated with Tubulointerstitial Nephritis and Uveitis

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Pathways related to Tubulointerstitial Nephritis and Uveitis according to GeneCards Suite gene sharing:

(show all 22)
idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
8.5HLA-DQA1, HLA-DQB1, HLA-DRB1
28.5HLA-DQA1, HLA-DQB1, HLA-DRB1
3
Show member pathways
8.5HLA-DQA1, HLA-DQB1, HLA-DRB1
4
Show member pathways
8.5HLA-DQA1, HLA-DQB1, HLA-DRB1
5
Show member pathways
8.5HLA-DQA1, HLA-DQB1, HLA-DRB1
6
Show member pathways
8.5HLA-DQA1, HLA-DQB1, HLA-DRB1
7
Show member pathways
8.5HLA-DQA1, HLA-DQB1, HLA-DRB1
8
Show member pathways
8.5HLA-DQA1, HLA-DQB1, HLA-DRB1
9
Show member pathways
8.5HLA-DQA1, HLA-DQB1, HLA-DRB1
10
Show member pathways
8.5HLA-DQA1, HLA-DQB1, HLA-DRB1
118.5HLA-DQA1, HLA-DQB1, HLA-DRB1
12
Show member pathways
8.5HLA-DQA1, HLA-DQB1, HLA-DRB1
13
Show member pathways
8.5HLA-DQA1, HLA-DQB1, HLA-DRB1
148.5HLA-DQA1, HLA-DQB1, HLA-DRB1
158.5HLA-DQA1, HLA-DQB1, HLA-DRB1
168.5HLA-DQA1, HLA-DQB1, HLA-DRB1
178.5HLA-DQA1, HLA-DQB1, HLA-DRB1
188.5HLA-DQA1, HLA-DQB1, HLA-DRB1
19
Show member pathways
8.5HLA-DQA1, HLA-DQB1, HLA-DRB1
208.5HLA-DQA1, HLA-DQB1, HLA-DRB1
21
Show member pathways
8.5HLA-DQA1, HLA-DQB1, HLA-DRB1
228.5HLA-DQA1, HLA-DQB1, HLA-DRB1

GO Terms for genes affiliated with Tubulointerstitial Nephritis and Uveitis

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Cellular components related to Tubulointerstitial Nephritis and Uveitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1MHC class II protein complexGO:00426139.8HLA-DQA1, HLA-DQB1
2integral component of lumenal side of endoplasmic reticulum membraneGO:00715569.7HLA-DQA1, HLA-DQB1
3endosome membraneGO:00100089.3HLA-DQA1, HLA-DQB1
4ER to Golgi transport vesicle membraneGO:00125078.5HLA-DQA1, HLA-DQB1, HLA-DRB1
5trans-Golgi network membraneGO:00325888.4HLA-DQA1, HLA-DQB1, HLA-DRB1

Biological processes related to Tubulointerstitial Nephritis and Uveitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1antigen processing and presentation of peptide or polysaccharide antigen via MHC class IIGO:00025049.6HLA-DQA1, HLA-DRB1
2immunoglobulin production involved in immunoglobulin mediated immune responseGO:00023819.5HLA-DQB1, HLA-DRB1
3cytokine-mediated signaling pathwayGO:00192219.1HLA-DQA1, HLA-DRB1
4antigen processing and presentationGO:00198828.7HLA-DQA1, HLA-DQB1, HLA-DRB1

Sources for Tubulointerstitial Nephritis and Uveitis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet