TINU
MCID: TBL013
MIFTS: 25

Tubulointerstitial Nephritis and Uveitis (TINU) malady

Eye, Nephrological categories

Summaries for Tubulointerstitial Nephritis and Uveitis

Sources:
47OMIM, 33MalaCards
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MalaCards: Tubulointerstitial Nephritis and Uveitis, also known as tubulointerstitial nephritis and uveitis syndrome, is related to uveitis and nephritis. An important gene associated with Tubulointerstitial Nephritis and Uveitis is HLA-DQA1 (major histocompatibility complex, class II, DQ alpha 1), and among its related pathways are TNF Signaling and Allograft rejection. The compounds dpa 1 and lapatinib have been mentioned in the context of this disorder.

Description from OMIM:47 607665

Aliases & Classifications for Tubulointerstitial Nephritis and Uveitis

Sources:
43NIH Rare Diseases, 61UMLS, 49Orphanet, 47OMIM, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye, Nephrological


Aliases & Descriptions:

tubulointerstitial nephritis and uveitis 43 61
tubulointerstitial nephritis and uveitis syndrome 49 47
tinu syndrome 43 49
acute tubulointerstitial nephritis and uveitis syndrome 49
tinu 43


External Ids:

OMIM47 607665
MESH via Orphanet36 C536922
ICD10 via Orphanet26 N10
SNOMED-CT via Orphanet58 418839003
UMLS via Orphanet62 C1639520, C2609298

Related Diseases for Tubulointerstitial Nephritis and Uveitis

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Tubulointerstitial Nephritis and Uveitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 51)
idRelated DiseaseScoreTop Affiliating Genes
1uveitis11.3
2nephritis11.3
3n syndrome11.2
4adult syndrome10.7
5fanconi syndrome10.6
6neuroretinitis10.5
7ankylosing spondylitis10.3
8choroiditis10.3
9good syndrome10.3
10worth's syndrome10.3
11spondylitis10.3
12thyroiditis10.3
13short syndrome10.3
14kid syndrome10.3
15multifocal choroiditis10.3
16anterior uveitis10.1
17pemphigus vulgaris10.0HLA-DRB1
18leprosy10.0HLA-DRB1
19narcolepsy10.0HLA-DRB1
20liver cirrhosis10.0HLA-DRB1
21pemphigus foliaceus10.0HLA-DRB1
22vogt-koyanagi-harada disease10.0HLA-DRB1
23psoriasis10.0HLA-DRB1
24hepatitis c10.0HLA-DRB1
25myasthenia gravis10.0HLA-DQB1
26encephalomyelitis10.0HLA-DQB1
27dermatitis herpetiformis10.0HLA-DQB1
28connective tissue disease10.0HLA-DRB1
29cervical cancer10.0HLA-DQB1
30atopy10.0HLA-DQA1
31hepatitis e10.0
32granulomatous hepatitis10.0
33posterior uveitis10.0
34hepatitis a10.0
35viral hepatitis10.0HLA-DRB1, HLA-DQA1
36asthma10.0HLA-DRB1, HLA-DQA1
37sarcoidosis10.0HLA-DRB1, HLA-DQB1
38dilated cardiomyopathy10.0HLA-DQB1, HLA-DRB1
39pulmonary tuberculosis10.0HLA-DRB1, HLA-DQB1
40autoimmune hepatitis10.0HLA-DRB1, HLA-DQB1
41celiac disease10.0HLA-DQB1, HLA-DQA1
42systemic scleroderma10.0HLA-DQB1, HLA-DRB1
43hypersensitivity reaction type ii disease10.0HLA-DRB1, HLA-DQB1
44juvenile rheumatoid arthritis10.0HLA-DRB1, HLA-DQA1, HLA-DQB1
45type 1 diabetes10.0HLA-DQA1, HLA-DRB1, HLA-DQB1
46systemic lupus erythematosus10.0HLA-DQA1, HLA-DRB1, HLA-DQB1
47graves' disease10.0HLA-DQB1, HLA-DRB1, HLA-DQA1
48rheumatoid arthritis10.0HLA-DQB1, HLA-DRB1
49diabetes mellitus10.0HLA-DRB1, HLA-DQB1, HLA-DQA1
50multiple sclerosis10.0HLA-DQB1, HLA-DRB1, HLA-DQA1

Graphical network of the top 20 diseases related to Tubulointerstitial Nephritis and Uveitis:



Diseases related to tubulointerstitial nephritis and uveitis

Clinical Features for Tubulointerstitial Nephritis and Uveitis

Sources:
47OMIM
See all sources

Clinical features from OMIM:

607665

Clinical synopsis from OMIM:

607665

Drugs & Therapeutics for Tubulointerstitial Nephritis and Uveitis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Tubulointerstitial Nephritis and Uveitis

Drug clinical trials:

Search ClinicalTrials for Tubulointerstitial Nephritis and Uveitis

Search NIH Clinical Center for Tubulointerstitial Nephritis and Uveitis

Search CenterWatch for Tubulointerstitial Nephritis and Uveitis

Genetic Tests for Tubulointerstitial Nephritis and Uveitis

Anatomical Context for Tubulointerstitial Nephritis and Uveitis

Animal Models for Tubulointerstitial Nephritis and Uveitis or affiliated genes

Sources:
28inGenious Targeting Laboratory
See all sources

Publications for Tubulointerstitial Nephritis and Uveitis

Genetic Variations for Tubulointerstitial Nephritis and Uveitis

Expression for genes affiliated with Tubulointerstitial Nephritis and Uveitis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Tubulointerstitial Nephritis and Uveitis

Search GEO for disease gene expression data for Tubulointerstitial Nephritis and Uveitis.

Pathways for genes affiliated with Tubulointerstitial Nephritis and Uveitis

Sources:
56SinoBiological, 30KEGG, 52QIAGEN, 54Reactome, 12EMD Millipore
See all sources

Pathways related to Tubulointerstitial Nephritis and Uveitis according to GeneCards/GeneDecks:

(show all 28)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.0HLA-DQA1, HLA-DQB1
2
Hide members
8.5HLA-DQB1, HLA-DRB1, HLA-DQA1
38.5HLA-DQB1, HLA-DRB1, HLA-DQA1
48.5HLA-DQB1, HLA-DRB1, HLA-DQA1
5
Hide members
8.5HLA-DQB1, HLA-DRB1, HLA-DQA1
6
Hide members
8.5HLA-DQB1, HLA-DRB1, HLA-DQA1
7
Hide members
8.5HLA-DQB1, HLA-DRB1, HLA-DQA1
88.5HLA-DQB1, HLA-DRB1, HLA-DQA1
98.5HLA-DQB1, HLA-DRB1, HLA-DQA1
108.5HLA-DQB1, HLA-DRB1, HLA-DQA1
11
Hide members
8.5HLA-DQB1, HLA-DRB1, HLA-DQA1
128.5HLA-DQB1, HLA-DRB1, HLA-DQA1
13
Hide members
8.5HLA-DQA1, HLA-DRB1, HLA-DQB1
14
Hide members
8.5HLA-DQA1, HLA-DRB1, HLA-DQB1
158.5HLA-DQA1, HLA-DRB1, HLA-DQB1
16
Hide members
8.5HLA-DQA1, HLA-DRB1, HLA-DQB1
17
Hide members
8.5HLA-DQA1, HLA-DRB1, HLA-DQB1
18
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8.5HLA-DQA1, HLA-DRB1, HLA-DQB1
19
Hide members
8.5HLA-DQA1, HLA-DRB1, HLA-DQB1
20
Hide members
8.5HLA-DQA1, HLA-DRB1, HLA-DQB1
218.5HLA-DQA1, HLA-DRB1, HLA-DQB1
22
Hide members
8.5HLA-DQA1, HLA-DRB1, HLA-DQB1
23
Immune response ICOS pathway in T-helper cell
Hide members
8.5HLA-DQA1, HLA-DRB1, HLA-DQB1
24
Immune response Antigen presentation by MHC class II
Hide members
8.5HLA-DQA1, HLA-DRB1, HLA-DQB1
25
Hide members
8.5HLA-DQA1, HLA-DRB1, HLA-DQB1
268.5HLA-DQA1, HLA-DRB1, HLA-DQB1
278.5HLA-DQA1, HLA-DRB1, HLA-DQB1
28
Immune response NFAT in immune response
Hide members
8.5HLA-DQA1, HLA-DRB1, HLA-DQB1

Compounds for genes affiliated with Tubulointerstitial Nephritis and Uveitis

Sources:
45Novoseek, 50PharmGKB, 11DrugBank
See all sources

Compounds related to Tubulointerstitial Nephritis and Uveitis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1dpa 1459.2HLA-DQA1, HLA-DRB1
2lapatinib45 50 1111.0HLA-DQA1, HLA-DRB1
3oligonucleotide458.5HLA-DQA1, HLA-DRB1, HLA-DQB1

GO Terms for genes affiliated with Tubulointerstitial Nephritis and Uveitis

Sources:
16Gene Ontology
See all sources

Cellular components related to Tubulointerstitial Nephritis and Uveitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endosome membraneGO:0100089.0HLA-DQA1, HLA-DQB1
2MHC class II protein complexGO:0426138.7HLA-DQA1, HLA-DRB1, HLA-DQB1
3clathrin-coated endocytic vesicle membraneGO:0306698.7HLA-DQA1, HLA-DRB1, HLA-DQB1
4integral to lumenal side of endoplasmic reticulum membraneGO:0715568.7HLA-DQB1, HLA-DRB1, HLA-DQA1
5transport vesicle membraneGO:0306588.7HLA-DQB1, HLA-DRB1, HLA-DQA1
6ER to Golgi transport vesicle membraneGO:0125078.6HLA-DQB1, HLA-DRB1, HLA-DQA1
7trans-Golgi network membraneGO:0325888.6HLA-DQA1, HLA-DRB1, HLA-DQB1
8endocytic vesicle membraneGO:0306668.5HLA-DQB1, HLA-DRB1, HLA-DQA1
9lysosomal membraneGO:0057658.4HLA-DQA1, HLA-DRB1, HLA-DQB1
10Golgi membraneGO:0001398.2HLA-DQA1, HLA-DRB1, HLA-DQB1

Biological processes related to Tubulointerstitial Nephritis and Uveitis according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1immunoglobulin production involved in immunoglobulin mediated immune responseGO:0023819.1HLA-DRB1, HLA-DQB1
2humoral immune response mediated by circulating immunoglobulinGO:0024559.0HLA-DRB1, HLA-DQB1
3interferon-gamma-mediated signaling pathwayGO:0603338.7HLA-DQA1, HLA-DRB1, HLA-DQB1
4T cell costimulationGO:0312958.7HLA-DQB1, HLA-DRB1, HLA-DQA1
5T cell receptor signaling pathwayGO:0508528.6HLA-DQA1, HLA-DRB1, HLA-DQB1
6antigen processing and presentation of exogenous peptide antigen via MHC class IIGO:0198868.6HLA-DQB1, HLA-DRB1, HLA-DQA1
7immune responseGO:0069558.5HLA-DQA1, HLA-DRB1, HLA-DQB1
8cytokine-mediated signaling pathwayGO:0192218.2HLA-DQB1, HLA-DRB1, HLA-DQA1

Molecular functions related to Tubulointerstitial Nephritis and Uveitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class II receptor activityGO:0323958.5HLA-DQA1, HLA-DRB1, HLA-DQB1

Products for genes affiliated with Tubulointerstitial Nephritis and Uveitis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Tubulointerstitial Nephritis and Uveitis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet