MCID: TBL013
MIFTS: 37

Tubulointerstitial Nephritis and Uveitis malady

Rare diseases, Eye diseases, Nephrological diseases categories

Summaries for Tubulointerstitial Nephritis and Uveitis

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MalaCards based summary: Tubulointerstitial Nephritis and Uveitis, also known as acute tubulointerstitial nephritis and uveitis syndrome, is related to graves' disease and uveitis, and has symptoms including panuveitis, glomerulonephritis and abnormality of the mouth. An important gene associated with Tubulointerstitial Nephritis and Uveitis is HLA-DQA1 (major histocompatibility complex, class II, DQ alpha 1), and among its related pathways are TNF Signaling and Influenza A. The compounds dpa 1 and lapatinib have been mentioned in the context of this disorder. Affiliated tissues include eye, thyroid and bone marrow.

Aliases & Classifications for Tubulointerstitial Nephritis and Uveitis

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Sources:
41NIH Rare Diseases, 60UMLS, 47Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet, 34MESH via Orphanet
See all sources

Tubulointerstitial Nephritis and Uveitis, Aliases & Descriptions:

Name: Tubulointerstitial Nephritis and Uveitis 41 60
Acute Tubulointerstitial Nephritis and Uveitis Syndrome 41 47
Tubulointerstitial Nephritis and Uveitis Syndrome 41 47
 
Tinu Syndrome 41 47
Tinu 41


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Eye diseases, Nephrological diseases


External Ids:

Orphanet47 91500
ICD10 via Orphanet26 N10
UMLS via Orphanet61 C1639520, C2609298
MESH via Orphanet34 C536922

Related Diseases for Tubulointerstitial Nephritis and Uveitis

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Graphical network of the top 20 diseases related to Tubulointerstitial Nephritis and Uveitis:



Diseases related to tubulointerstitial nephritis and uveitis

Symptoms for Tubulointerstitial Nephritis and Uveitis

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HPO human phenotypes related to Tubulointerstitial Nephritis and Uveitis:

(show all 9)
id Description Frequency HPO Source Accession
1 panuveitis rare (5%) HP:0012121
2 glomerulonephritis HP:0000099
3 abnormality of the mouth HP:0000153
4 uveitis HP:0000554
5 sporadic HP:0003745
6 reversible renal failure HP:0004713
7 acute tubulointerstitial nephritis HP:0004729
8 non-caseating epithelioid cell granulomatosis HP:0012220
9 circulating immune complexes HP:0012224

Drugs & Therapeutics for Tubulointerstitial Nephritis and Uveitis

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Drug clinical trials:

Search ClinicalTrials for Tubulointerstitial Nephritis and Uveitis

Search NIH Clinical Center for Tubulointerstitial Nephritis and Uveitis

Genetic Tests for Tubulointerstitial Nephritis and Uveitis

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Anatomical Context for Tubulointerstitial Nephritis and Uveitis

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MalaCards organs/tissues related to Tubulointerstitial Nephritis and Uveitis:

31
Eye, Thyroid, Bone marrow, Bone, Kidney, Lung

Animal Models for Tubulointerstitial Nephritis and Uveitis or affiliated genes

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Publications for Tubulointerstitial Nephritis and Uveitis

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Articles related to Tubulointerstitial Nephritis and Uveitis:

(show top 50)    (show all 88)
idTitleAuthorsYear
1
A report of an adult case of tubulointerstitial nephritis and uveitis (TINU) syndrome, with a review of 102 Japanese cases. (25725230)
2015
2
Acute granulomatous iridocyclitis in a child with tubulointerstitial nephritis and uveitis syndrome. (25861394)
2015
3
Tubulointerstitial Nephritis and Uveitis Syndrome with non caseating granuloma in bone marrow biopsy. (24813498)
2014
4
Neuroretinitis: a rare feature of tubulointerstitial nephritis and uveitis syndrome. (23824660)
2013
5
HLA-DR, DQ Class II DNA Typing in Pediatric Panuveitis and Tubulointerstitial Nephritis and Uveitis (TINU). (24321473)
2013
6
A boy with IgA nephropathy complicated by tubulointerstitial nephritis and uveitis (TINU) syndrome. (24075025)
2013
7
Tubulointerstitial nephritis and uveitis syndrome in an older adult: a case report and review of the literature. (24117310)
2013
8
Moth-eaten appearance of tubulointerstitial nephritis and uveitis syndrome on (99m)technetium dimercaptosuccinic acid scintigraphy. (23092525)
2013
9
Two cases of subfoveal choroidal neovascularization with tubulointerstitial nephritis and uveitis syndrome. (23335312)
2013
10
Tubulointerstitial nephritis and uveitis syndrome in a twelve-year-old girl. (23691408)
2013
11
Tubulointerstitial nephritis and uveitis syndrome with concomitant Hashimoto's thyroiditis. (24601328)
2013
12
Excellent outcome of tubulointerstitial nephritis and uveitis: case report and five-year follow-up. (22681193)
2012
13
TINU (tubulointerstitial nephritis and uveitis) syndrome is not usually associated with IgG4 sclerosing disease. (22277743)
2012
14
Tubulointerstitial nephritis and uveitis: report of a rare syndrome. (21189439)
2011
15
Tubulointerstitial nephritis and uveitis syndrome with transient hyperthyroidism in an elderly patient. (21823045)
2011
16
Recurrent tubulointerstitial nephritis and uveitis syndrome in a renal transplant recipient. (21673077)
2011
17
Tubulointerstitial nephritis and uveitis (TINU) syndrome caused by the Chinese herb "Goreisan". (18661195)
2009
18
Short course of cyclophosphamide therapy may reduce recurrence in patients with tubulointerstitial nephritis and uveitis syndrome. (19587511)
2009
19
A Case of Tubulointerstitial Nephritis and Uveitis (TINU) Syndrome with High ASLO Titer. (24179369)
2009
20
Syndrome of tubulointerstitial nephritis and uveitis. (19582990)
2009
21
Is tubulointerstitial nephritis and uveitis syndrome associated with IgG4-related systemic disease? (18199112)
2008
22
Tubulointerstitial nephritis and uveitis syndrome (TINU): a step forward to understanding an elusive oculorenal syndrome. (18272778)
2008
23
Recurrent and progressive nephritis in a patient with acute tubulointerstitial nephritis and uveitis syndrome. (18218320)
2008
24
Human leucocyte antigen DQ alpha heterodimers and human leucocyte antigen DR alleles in tubulointerstitial nephritis and uveitis syndrome. (19154326)
2008
25
Presence of autoantibodies against tubular and uveal cells in a patient with tubulointerstitial nephritis and uveitis (TINU) syndrome. (18156461)
2008
26
Tubulointerstitial nephritis and uveitis syndrome. (18427256)
2008
27
Enhanced recognition, treatment, and prognosis of tubulointerstitial nephritis and uveitis syndrome. (17383731)
2007
28
Lymphoid interstitial lung disease in a patient with acute tubulointerstitial nephritis and uveitis: a new facet of a rare syndrome? (16564933)
2006
29
Elevation of serum Krebs von den Lunge-6 levels in patients with tubulointerstitial nephritis and uveitis syndrome. (17162148)
2006
30
Adult onset tubulointerstitial nephritis and uveitis syndrome. (16109092)
2005
31
A case of tubulointerstitial nephritis and uveitis syndrome with severe immunologic dysregulation. (16208535)
2005
32
Tubulointerstitial nephritis and uveitis syndrome (TINU syndrome) with unilateral neuroretinitis: a case report. (15309980)
2004
33
Strong associations between specific HLA-DQ and HLA-DR alleles and the tubulointerstitial nephritis and uveitis syndrome. (12556395)
2003
34
A case of adult-onset tubulointerstitial nephritis and uveitis ("TINU syndrome") associated with sacroileitis and Epstein-Barr virus infection with good spontaneous outcome. (12955704)
2003
35
Tubulointerstitial nephritis and uveitis syndrome: a diagnosis that should be considered by rheumatologists. (12594128)
2003
36
The tubulointerstitial nephritis and uveitis syndrome. (12052421)
2002
37
Tubulointerstitial nephritis and uveitis syndrome. (11698749)
2001
38
Tubulointerstitial nephritis and uveitis syndrome in two siblings. (11556736)
2001
39
The tubulointerstitial nephritis and uveitis syndrome. (11738428)
2001
40
Repeat renal biopsy in a girl with tubulointerstitial nephritis and uveitis syndrome. (11685594)
2001
41
Tubulointerstitial nephritis and uveitis syndrome with autoantibody directed to renal tubular cells. (11389273)
2001
42
Tubulointerstitial nephritis and uveitis with bilateral multifocal choroiditis. (10926997)
2000
43
Acute tubulointerstitial nephritis and uveitis with angiotensin-converting enzyme increase. (10529642)
1999
44
Tubulointerstitial nephritis and uveitis in children and adolescents. Four new cases and a review of the literature. (10412864)
1999
45
Tubulointerstitial nephritis and uveitis in association with Epstein-Barr virus infection. (10454786)
1999
46
Tubulointerstitial nephritis and uveitis: an immunological disorder? (7794717)
1995
47
Clinical and immune aspects of idiopathic acute tubulointerstitial nephritis and uveitis syndrome. (7503137)
1995
48
Tubulointerstitial nephritis and uveitis: association with suppressed cellular immunity. (8255514)
1993
49
Syndrome of tubulointerstitial nephritis and uveitis: is it worth considering it as a proper entity? (8367000)
1993
50
Primary tubulointerstitial nephritis and uveitis syndrome. (8148149)
1993

Variations for Tubulointerstitial Nephritis and Uveitis

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Expression for genes affiliated with Tubulointerstitial Nephritis and Uveitis

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Search GEO for disease gene expression data for Tubulointerstitial Nephritis and Uveitis.

Pathways for genes affiliated with Tubulointerstitial Nephritis and Uveitis

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Pathways related to Tubulointerstitial Nephritis and Uveitis according to GeneCards Suite gene sharing:

(show all 25)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.0HLA-DQA1, HLA-DQB1
2
Show member pathways
8.5HLA-DRB1, HLA-DQA1, HLA-DQB1
3
Show member pathways
8.5HLA-DRB1, HLA-DQA1, HLA-DQB1
4
Show member pathways
8.5HLA-DRB1, HLA-DQA1, HLA-DQB1
58.5HLA-DRB1, HLA-DQA1, HLA-DQB1
6
Show member pathways
8.5HLA-DRB1, HLA-DQA1, HLA-DQB1
7
Show member pathways
8.5HLA-DRB1, HLA-DQA1, HLA-DQB1
8
Show member pathways
8.5HLA-DRB1, HLA-DQA1, HLA-DQB1
9
Show member pathways
8.5HLA-DRB1, HLA-DQA1, HLA-DQB1
10
Show member pathways
8.5HLA-DRB1, HLA-DQA1, HLA-DQB1
11
Show member pathways
8.5HLA-DRB1, HLA-DQA1, HLA-DQB1
12
Show member pathways
Immune response IL 22 signaling pathway58
G protein signaling N RAS regulation pathway58
8.5HLA-DRB1, HLA-DQA1, HLA-DQB1
138.5HLA-DRB1, HLA-DQA1, HLA-DQB1
14
Show member pathways
8.5HLA-DRB1, HLA-DQA1, HLA-DQB1
158.5HLA-DRB1, HLA-DQA1, HLA-DQB1
16
Show member pathways
8.5HLA-DQB1, HLA-DQA1, HLA-DRB1
17
Show member pathways
8.5HLA-DQB1, HLA-DQA1, HLA-DRB1
188.5HLA-DQB1, HLA-DQA1, HLA-DRB1
198.5HLA-DQB1, HLA-DQA1, HLA-DRB1
208.5HLA-DQB1, HLA-DQA1, HLA-DRB1
21
Show member pathways
8.5HLA-DQB1, HLA-DQA1, HLA-DRB1
228.5HLA-DQB1, HLA-DQA1, HLA-DRB1
23
Show member pathways
Immune response T cell receptor signaling pathway58
Immune response CD28 signaling58
Immune response ICOS pathway in T helper cell58
8.5HLA-DQB1, HLA-DQA1, HLA-DRB1
248.5HLA-DQB1, HLA-DQA1, HLA-DRB1
25
Show member pathways
8.5HLA-DQB1, HLA-DQA1, HLA-DRB1

Compounds for genes affiliated with Tubulointerstitial Nephritis and Uveitis

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Sources:
43Novoseek, 49PharmGKB, 12DrugBank
See all sources

Compounds related to Tubulointerstitial Nephritis and Uveitis according to GeneCards Suite gene sharing:

idCompoundScoreTop Affiliating Genes
1dpa 1439.3HLA-DRB1, HLA-DQA1
2lapatinib43 49 1211.2HLA-DRB1, HLA-DQA1
3aspartate439.0HLA-DQA1, HLA-DQB1
4oligonucleotide438.2HLA-DRB1, HLA-DQA1, HLA-DQB1

GO Terms for genes affiliated with Tubulointerstitial Nephritis and Uveitis

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Cellular components related to Tubulointerstitial Nephritis and Uveitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1endosome membraneGO:00100089.0HLA-DQA1, HLA-DQB1
2MHC class II protein complexGO:00426138.7HLA-DRB1, HLA-DQA1, HLA-DQB1
3integral component of lumenal side of endoplasmic reticulum membraneGO:00715568.7HLA-DRB1, HLA-DQA1, HLA-DQB1
4clathrin-coated endocytic vesicle membraneGO:00306698.7HLA-DQB1, HLA-DQA1, HLA-DRB1
5transport vesicle membraneGO:00306588.7HLA-DRB1, HLA-DQA1, HLA-DQB1
6ER to Golgi transport vesicle membraneGO:00125078.6HLA-DQB1, HLA-DQA1, HLA-DRB1
7trans-Golgi network membraneGO:00325888.6HLA-DRB1, HLA-DQA1, HLA-DQB1
8endocytic vesicle membraneGO:00306668.5HLA-DRB1, HLA-DQA1, HLA-DQB1
9lysosomal membraneGO:00057658.4HLA-DQB1, HLA-DQA1, HLA-DRB1
10Golgi membraneGO:00001398.2HLA-DRB1, HLA-DQA1, HLA-DQB1

Biological processes related to Tubulointerstitial Nephritis and Uveitis according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1immunoglobulin production involved in immunoglobulin mediated immune responseGO:00023819.1HLA-DRB1, HLA-DQB1
2humoral immune response mediated by circulating immunoglobulinGO:00024559.0HLA-DRB1, HLA-DQB1
3interferon-gamma-mediated signaling pathwayGO:00603338.7HLA-DRB1, HLA-DQA1, HLA-DQB1
4T cell costimulationGO:00312958.7HLA-DQB1, HLA-DQA1, HLA-DRB1
5T cell receptor signaling pathwayGO:00508528.6HLA-DRB1, HLA-DQA1, HLA-DQB1
6antigen processing and presentation of exogenous peptide antigen via MHC class IIGO:00198868.6HLA-DQB1, HLA-DQA1, HLA-DRB1
7immune responseGO:00069558.5HLA-DRB1, HLA-DQA1, HLA-DQB1
8cytokine-mediated signaling pathwayGO:00192218.2HLA-DQB1, HLA-DQA1, HLA-DRB1

Molecular functions related to Tubulointerstitial Nephritis and Uveitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1MHC class II receptor activityGO:00323958.5HLA-DRB1, HLA-DQA1, HLA-DQB1

Products for genes affiliated with Tubulointerstitial Nephritis and Uveitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Tubulointerstitial Nephritis and Uveitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet