TINU
MCID: TBL013
MIFTS: 32

Tubulointerstitial Nephritis and Uveitis (TINU) malady

Eye diseases, Nephrological diseases categories

Summaries for Tubulointerstitial Nephritis and Uveitis

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46OMIM, 32MalaCards
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MalaCards: Tubulointerstitial Nephritis and Uveitis, also known as tubulointerstitial nephritis and uveitis syndrome, is related to uveitis and adult syndrome. An important gene associated with Tubulointerstitial Nephritis and Uveitis is HLA-DQA1 (major histocompatibility complex, class II, DQ alpha 1), and among its related pathways are TNF Signaling and Allograft rejection. The compounds dpa 1 and lapatinib have been mentioned in the context of this disorder. Affiliated tissues include eye.

Description from OMIM:46 607665

Aliases & Classifications for Tubulointerstitial Nephritis and Uveitis

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Sources:
42NIH Rare Diseases, 60UMLS, 48Orphanet, 46OMIM, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases, Nephrological diseases


Aliases & Descriptions:

tubulointerstitial nephritis and uveitis 42 60
tubulointerstitial nephritis and uveitis syndrome 48 46
tinu syndrome 42 48
acute tubulointerstitial nephritis and uveitis syndrome 48
tinu 42


External Ids:

OMIM46 607665
MESH via Orphanet35 C536922
ICD10 via Orphanet26 N10
SNOMED-CT via Orphanet57 418839003
UMLS via Orphanet61 C1639520, C2609298

Related Diseases for Tubulointerstitial Nephritis and Uveitis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Tubulointerstitial Nephritis and Uveitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 50)
idRelated DiseaseScoreTop Affiliating Genes
1uveitis11.2
2adult syndrome10.6
3neuroretinitis10.4
4choroiditis10.4
5fanconi syndrome10.4
6hyperthyroidism10.4
7ankylosing spondylitis10.3
8interstitial lung disease10.3
9interstitial nephritis10.3
10panuveitis10.3
11retinitis10.3
12spondylitis10.3
13thyroiditis10.3
14pemphigus vulgaris10.0HLA-DRB1
15leprosy10.0HLA-DRB1
16narcolepsy10.0HLA-DRB1
17liver cirrhosis10.0HLA-DRB1
18pemphigus foliaceus10.0HLA-DRB1
19vogt-koyanagi-harada disease10.0HLA-DRB1
20psoriasis10.0HLA-DRB1
21hepatitis c10.0HLA-DRB1
22myasthenia gravis10.0HLA-DQB1
23encephalomyelitis10.0HLA-DQB1
24dermatitis herpetiformis10.0HLA-DQB1
25connective tissue disease10.0HLA-DRB1
26cervical cancer10.0HLA-DQB1
27atopy10.0HLA-DQA1
28viral hepatitis10.0HLA-DQA1, HLA-DRB1
29asthma10.0HLA-DQA1, HLA-DRB1
30sarcoidosis10.0HLA-DRB1, HLA-DQB1
31dilated cardiomyopathy10.0HLA-DRB1, HLA-DQB1
32pulmonary tuberculosis10.0HLA-DRB1, HLA-DQB1
33autoimmune hepatitis10.0HLA-DRB1, HLA-DQB1
34celiac disease10.0HLA-DQA1, HLA-DQB1
35systemic scleroderma10.0HLA-DQB1, HLA-DRB1
36hypersensitivity reaction type ii disease10.0HLA-DRB1, HLA-DQB1
37rheumatoid arthritis10.0HLA-DRB1, HLA-DQB1
38juvenile rheumatoid arthritis10.0HLA-DQA1, HLA-DRB1, HLA-DQB1
39type 1 diabetes10.0HLA-DQB1, HLA-DRB1, HLA-DQA1
40systemic lupus erythematosus10.0HLA-DQA1, HLA-DRB1, HLA-DQB1
41graves' disease10.0HLA-DQB1, HLA-DRB1, HLA-DQA1
42diabetes mellitus10.0HLA-DQA1, HLA-DRB1, HLA-DQB1
43multiple sclerosis10.0HLA-DQA1, HLA-DRB1, HLA-DQB1
44granulomatous hepatitis10.0
45posterior uveitis10.0
46chorioretinal scar10.0
47chorioretinitis10.0
48hepatitis10.0
49scleritis10.0
50hepatitis b10.0HLA-DQA1, HLA-DRB1, HLA-DQB1

Graphical network of the top 20 diseases related to Tubulointerstitial Nephritis and Uveitis:



Diseases related to tubulointerstitial nephritis and uveitis

Clinical Features for Tubulointerstitial Nephritis and Uveitis

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Sources:
46OMIM
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Clinical features from OMIM:

607665

Clinical synopsis from OMIM:

607665

Drugs & Therapeutics for Tubulointerstitial Nephritis and Uveitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Tubulointerstitial Nephritis and Uveitis

Drug clinical trials:

Search ClinicalTrials for Tubulointerstitial Nephritis and Uveitis

Search NIH Clinical Center for Tubulointerstitial Nephritis and Uveitis

Search CenterWatch for Tubulointerstitial Nephritis and Uveitis

Genetic Tests for Tubulointerstitial Nephritis and Uveitis

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Anatomical Context for Tubulointerstitial Nephritis and Uveitis

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Sources:
32MalaCards
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MalaCards organs/tissues related to Tubulointerstitial Nephritis and Uveitis:

32
Eye

Animal Models for Tubulointerstitial Nephritis and Uveitis or affiliated genes

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Publications for Tubulointerstitial Nephritis and Uveitis

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Genetic Variations for Tubulointerstitial Nephritis and Uveitis

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Expression for genes affiliated with Tubulointerstitial Nephritis and Uveitis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Tubulointerstitial Nephritis and Uveitis

Search GEO for disease gene expression data for Tubulointerstitial Nephritis and Uveitis.

Pathways for genes affiliated with Tubulointerstitial Nephritis and Uveitis

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Sources:
55SinoBiological, 29KEGG, 51QIAGEN, 53Reactome, 12EMD Millipore
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Pathways related to Tubulointerstitial Nephritis and Uveitis according to GeneCards/GeneDecks:

(show all 28)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.0HLA-DQA1, HLA-DQB1
2
Hide members
8.5HLA-DQB1, HLA-DRB1, HLA-DQA1
38.5HLA-DQB1, HLA-DRB1, HLA-DQA1
48.5HLA-DQB1, HLA-DRB1, HLA-DQA1
5
Hide members
8.5HLA-DQB1, HLA-DRB1, HLA-DQA1
6
Hide members
8.5HLA-DQB1, HLA-DRB1, HLA-DQA1
7
Hide members
8.5HLA-DQB1, HLA-DRB1, HLA-DQA1
88.5HLA-DQB1, HLA-DRB1, HLA-DQA1
98.5HLA-DQB1, HLA-DRB1, HLA-DQA1
108.5HLA-DQB1, HLA-DRB1, HLA-DQA1
11
Hide members
8.5HLA-DQB1, HLA-DRB1, HLA-DQA1
128.5HLA-DQB1, HLA-DRB1, HLA-DQA1
13
Hide members
8.5HLA-DQA1, HLA-DRB1, HLA-DQB1
14
Hide members
8.5HLA-DQA1, HLA-DRB1, HLA-DQB1
158.5HLA-DQA1, HLA-DRB1, HLA-DQB1
16
Hide members
8.5HLA-DQA1, HLA-DRB1, HLA-DQB1
17
Hide members
8.5HLA-DQA1, HLA-DRB1, HLA-DQB1
18
Hide members
8.5HLA-DQA1, HLA-DRB1, HLA-DQB1
19
Hide members
8.5HLA-DQA1, HLA-DRB1, HLA-DQB1
20
Hide members
8.5HLA-DQA1, HLA-DRB1, HLA-DQB1
218.5HLA-DQA1, HLA-DRB1, HLA-DQB1
22
Hide members
8.5HLA-DQA1, HLA-DRB1, HLA-DQB1
23
Immune response ICOS pathway in T-helper cell
Hide members
8.5HLA-DQA1, HLA-DRB1, HLA-DQB1
24
Immune response Antigen presentation by MHC class II
Hide members
8.5HLA-DQA1, HLA-DRB1, HLA-DQB1
25
Hide members
8.5HLA-DQA1, HLA-DRB1, HLA-DQB1
268.5HLA-DQA1, HLA-DRB1, HLA-DQB1
278.5HLA-DQA1, HLA-DRB1, HLA-DQB1
28
Immune response NFAT in immune response
Hide members
8.5HLA-DQA1, HLA-DRB1, HLA-DQB1

Compounds for genes affiliated with Tubulointerstitial Nephritis and Uveitis

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank
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Compounds related to Tubulointerstitial Nephritis and Uveitis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1dpa 1449.2HLA-DQA1, HLA-DRB1
2lapatinib44 49 1111.0HLA-DQA1, HLA-DRB1
3oligonucleotide448.5HLA-DQA1, HLA-DRB1, HLA-DQB1

GO Terms for genes affiliated with Tubulointerstitial Nephritis and Uveitis

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Sources:
16Gene Ontology
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Cellular components related to Tubulointerstitial Nephritis and Uveitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endosome membraneGO:0100089.0HLA-DQA1, HLA-DQB1
2MHC class II protein complexGO:0426138.7HLA-DQA1, HLA-DRB1, HLA-DQB1
3clathrin-coated endocytic vesicle membraneGO:0306698.7HLA-DQA1, HLA-DRB1, HLA-DQB1
4integral to lumenal side of endoplasmic reticulum membraneGO:0715568.7HLA-DQB1, HLA-DRB1, HLA-DQA1
5transport vesicle membraneGO:0306588.7HLA-DQB1, HLA-DRB1, HLA-DQA1
6ER to Golgi transport vesicle membraneGO:0125078.6HLA-DQB1, HLA-DRB1, HLA-DQA1
7trans-Golgi network membraneGO:0325888.6HLA-DQA1, HLA-DRB1, HLA-DQB1
8endocytic vesicle membraneGO:0306668.5HLA-DQB1, HLA-DRB1, HLA-DQA1
9lysosomal membraneGO:0057658.4HLA-DQA1, HLA-DRB1, HLA-DQB1
10Golgi membraneGO:0001398.2HLA-DQA1, HLA-DRB1, HLA-DQB1

Biological processes related to Tubulointerstitial Nephritis and Uveitis according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1immunoglobulin production involved in immunoglobulin mediated immune responseGO:0023819.1HLA-DRB1, HLA-DQB1
2humoral immune response mediated by circulating immunoglobulinGO:0024559.0HLA-DRB1, HLA-DQB1
3interferon-gamma-mediated signaling pathwayGO:0603338.7HLA-DQA1, HLA-DRB1, HLA-DQB1
4T cell costimulationGO:0312958.7HLA-DQB1, HLA-DRB1, HLA-DQA1
5T cell receptor signaling pathwayGO:0508528.6HLA-DQA1, HLA-DRB1, HLA-DQB1
6antigen processing and presentation of exogenous peptide antigen via MHC class IIGO:0198868.6HLA-DQB1, HLA-DRB1, HLA-DQA1
7immune responseGO:0069558.5HLA-DQA1, HLA-DRB1, HLA-DQB1
8cytokine-mediated signaling pathwayGO:0192218.2HLA-DQB1, HLA-DRB1, HLA-DQA1

Molecular functions related to Tubulointerstitial Nephritis and Uveitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class II receptor activityGO:0323958.5HLA-DQA1, HLA-DRB1, HLA-DQB1

Products for genes affiliated with Tubulointerstitial Nephritis and Uveitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Tubulointerstitial Nephritis and Uveitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet