TINU
MCID: TBL013
MIFTS: 43

Tubulointerstitial Nephritis and Uveitis (TINU) malady

Rare diseases, Eye diseases, Nephrological diseases categories
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Summaries for Tubulointerstitial Nephritis and Uveitis

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MalaCards based summary: Tubulointerstitial Nephritis and Uveitis, also known as tubulointerstitial nephritis and uveitis syndrome, is related to graves' disease and uveitis, and has symptoms including An important gene associated with Tubulointerstitial Nephritis and Uveitis is HLA-DQA1 (major histocompatibility complex, class II, DQ alpha 1), and among its related pathways are TNF Signaling and Influenza A. The compounds dpa 1 and lapatinib have been mentioned in the context of this disorder. Affiliated tissues include eye, thyroid and bone marrow.

Description from OMIM:46 607665

Aliases & Classifications for Tubulointerstitial Nephritis and Uveitis

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Sources:
42NIH Rare Diseases, 48Orphanet, 46OMIM, 62UMLS, 26ICD10 via Orphanet, 63UMLS via Orphanet, 35MESH via Orphanet
See all sources

Tubulointerstitial Nephritis and Uveitis, Aliases & Descriptions:

Name: Tubulointerstitial Nephritis and Uveitis 42 62
Tubulointerstitial Nephritis and Uveitis Syndrome 48 46
Tinu Syndrome 42 48
 
Acute Tubulointerstitial Nephritis and Uveitis Syndrome 48
Tinu 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Eye diseases, Nephrological diseases


External Ids:

ICD10 via Orphanet26 N10
UMLS via Orphanet63 C1639520, C2609298
OMIM46 607665
MESH via Orphanet35 C536922

Related Diseases for Tubulointerstitial Nephritis and Uveitis

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Diseases related to Tubulointerstitial Nephritis and Uveitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 41)
idRelated DiseaseScoreTop Affiliating Genes
1graves' disease30.2HLA-DQB1, HLA-DQA1, HLA-DRB1
2uveitis11.3
3nephritis11.3
4fanconi syndrome10.5
5neuroretinitis10.5
6choroiditis10.5
7hyperthyroidism10.5
8thyroiditis10.5
9interstitial nephritis10.4
10narcolepsy10.4HLA-DRB1
11ankylosing spondylitis10.3
12interstitial lung disease10.3
13panuveitis10.3
14retinitis10.3
15spondylitis10.3
16multifocal choroiditis10.3
17anterior uveitis10.2
18viral hepatitis10.1HLA-DRB1, HLA-DQA1
19multiple sclerosis 110.0HLA-DRB1, HLA-DQB1
20hepatitis10.0
21granulomatous hepatitis10.0
22posterior uveitis10.0
23chorioretinal scar10.0
24chorioretinitis10.0
25scleritis10.0
26pulmonary tuberculosis10.0HLA-DQB1, HLA-DRB1
27autoimmune hepatitis10.0HLA-DQB1, HLA-DRB1
28hepatitis b10.0HLA-DRB1, HLA-DQB1
29asthma10.0HLA-DRB1, HLA-DQA1
30hypersensitivity reaction type ii disease9.9HLA-DRB1, HLA-DQB1
31sarcoidosis9.9HLA-DQB1, HLA-DRB1
32celiac disease9.9HLA-DQB1, HLA-DQA1
33dilated cardiomyopathy9.9HLA-DQB1, HLA-DRB1
34systemic scleroderma9.9HLA-DQB1, HLA-DRB1
35tuberculosis9.8HLA-DRB1, HLA-DQB1
36juvenile rheumatoid arthritis9.8HLA-DRB1, HLA-DQA1, HLA-DQB1
37type 1 diabetes mellitus9.8HLA-DRB1, HLA-DQB1, HLA-DQA1
38schizophrenia9.8HLA-DQB1, HLA-DRB1
39systemic lupus erythematosus9.7HLA-DQB1, HLA-DQA1, HLA-DRB1
40multiple sclerosis9.7HLA-DQB1, HLA-DQA1, HLA-DRB1
41diabetes mellitus9.7HLA-DQA1, HLA-DQB1, HLA-DRB1

Graphical network of the top 20 diseases related to Tubulointerstitial Nephritis and Uveitis:



Diseases related to tubulointerstitial nephritis and uveitis

Symptoms for Tubulointerstitial Nephritis and Uveitis

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Symptoms by clinical synopsis from OMIM:

607665

Clinical features from OMIM:

607665

HPO human phenotypes related to Tubulointerstitial Nephritis and Uveitis:

(show all 9)
id Description Frequency HPO Source Accession
1 panuveitis rare (5%) HP:0012121
2 glomerulonephritis HP:0000099
3 abnormality of the mouth HP:0000153
4 uveitis HP:0000554
5 sporadic HP:0003745
6 reversible renal failure HP:0004713
7 acute tubulointerstitial nephritis HP:0004729
8 non-caseating epithelioid cell granulomatosis HP:0012220
9 circulating immune complexes HP:0012224

Drugs & Therapeutics for Tubulointerstitial Nephritis and Uveitis

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Drug clinical trials:

Search ClinicalTrials for Tubulointerstitial Nephritis and Uveitis

Search NIH Clinical Center for Tubulointerstitial Nephritis and Uveitis

Genetic Tests for Tubulointerstitial Nephritis and Uveitis

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Anatomical Context for Tubulointerstitial Nephritis and Uveitis

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MalaCards organs/tissues related to Tubulointerstitial Nephritis and Uveitis:

32
Eye, Thyroid, Bone marrow, Bone, Kidney, Lung

Animal Models for Tubulointerstitial Nephritis and Uveitis or affiliated genes

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Publications for Tubulointerstitial Nephritis and Uveitis

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Articles related to Tubulointerstitial Nephritis and Uveitis:

(show top 50)    (show all 86)
idTitleAuthorsYear
1
Tubulointerstitial Nephritis and Uveitis Syndrome with non caseating granuloma in bone marrow biopsy. (24813498)
2014
2
Neuroretinitis: a rare feature of tubulointerstitial nephritis and uveitis syndrome. (23824660)
2013
3
HLA-DR, DQ Class II DNA Typing in Pediatric Panuveitis and Tubulointerstitial Nephritis and Uveitis (TINU). (24321473)
2013
4
A boy with IgA nephropathy complicated by tubulointerstitial nephritis and uveitis (TINU) syndrome. (24075025)
2013
5
Tubulointerstitial nephritis and uveitis syndrome in an older adult: a case report and review of the literature. (24117310)
2013
6
Moth-eaten appearance of tubulointerstitial nephritis and uveitis syndrome on (99m)technetium dimercaptosuccinic acid scintigraphy. (23092525)
2013
7
Two cases of subfoveal choroidal neovascularization with tubulointerstitial nephritis and uveitis syndrome. (23335312)
2013
8
Tubulointerstitial nephritis and uveitis syndrome in a twelve-year-old girl. (23691408)
2013
9
Tubulointerstitial nephritis and uveitis syndrome with concomitant Hashimoto's thyroiditis. (24601328)
2013
10
Excellent outcome of tubulointerstitial nephritis and uveitis: case report and five-year follow-up. (22681193)
2012
11
TINU (tubulointerstitial nephritis and uveitis) syndrome is not usually associated with IgG4 sclerosing disease. (22277743)
2012
12
Tubulointerstitial nephritis and uveitis: report of a rare syndrome. (21189439)
2011
13
Tubulointerstitial nephritis and uveitis syndrome with transient hyperthyroidism in an elderly patient. (21823045)
2011
14
Recurrent tubulointerstitial nephritis and uveitis syndrome in a renal transplant recipient. (21673077)
2011
15
Tubulointerstitial nephritis and uveitis (TINU) syndrome caused by the Chinese herb "Goreisan". (18661195)
2009
16
Short course of cyclophosphamide therapy may reduce recurrence in patients with tubulointerstitial nephritis and uveitis syndrome. (19587511)
2009
17
A Case of Tubulointerstitial Nephritis and Uveitis (TINU) Syndrome with High ASLO Titer. (24179369)
2009
18
Syndrome of tubulointerstitial nephritis and uveitis. (19582990)
2009
19
Is tubulointerstitial nephritis and uveitis syndrome associated with IgG4-related systemic disease? (18199112)
2008
20
Tubulointerstitial nephritis and uveitis syndrome (TINU): a step forward to understanding an elusive oculorenal syndrome. (18272778)
2008
21
Recurrent and progressive nephritis in a patient with acute tubulointerstitial nephritis and uveitis syndrome. (18218320)
2008
22
Human leucocyte antigen DQ alpha heterodimers and human leucocyte antigen DR alleles in tubulointerstitial nephritis and uveitis syndrome. (19154326)
2008
23
Presence of autoantibodies against tubular and uveal cells in a patient with tubulointerstitial nephritis and uveitis (TINU) syndrome. (18156461)
2008
24
Tubulointerstitial nephritis and uveitis syndrome in a mother and her son. (18528711)
2008
25
Tubulointerstitial nephritis and uveitis syndrome. (18427256)
2008
26
Enhanced recognition, treatment, and prognosis of tubulointerstitial nephritis and uveitis syndrome. (17383731)
2007
27
Lymphoid interstitial lung disease in a patient with acute tubulointerstitial nephritis and uveitis: a new facet of a rare syndrome? (16564933)
2006
28
Elevation of serum Krebs von den Lunge-6 levels in patients with tubulointerstitial nephritis and uveitis syndrome. (17162148)
2006
29
Adult onset tubulointerstitial nephritis and uveitis syndrome. (16109092)
2005
30
A case of tubulointerstitial nephritis and uveitis syndrome with severe immunologic dysregulation. (16208535)
2005
31
Tubulointerstitial nephritis and uveitis syndrome (TINU syndrome) with unilateral neuroretinitis: a case report. (15309980)
2004
32
Tubulointerstitial nephritis and uveitis in monozygotic twin boys. (15206033)
2004
33
Strong associations between specific HLA-DQ and HLA-DR alleles and the tubulointerstitial nephritis and uveitis syndrome. (12556395)
2003
34
A case of adult-onset tubulointerstitial nephritis and uveitis ("TINU syndrome") associated with sacroileitis and Epstein-Barr virus infection with good spontaneous outcome. (12955704)
2003
35
Tubulointerstitial nephritis and uveitis syndrome: a diagnosis that should be considered by rheumatologists. (12594128)
2003
36
The tubulointerstitial nephritis and uveitis syndrome. (12052421)
2002
37
Tubulointerstitial nephritis and uveitis syndrome. (11698749)
2001
38
Tubulointerstitial nephritis and uveitis syndrome in two siblings. (11556736)
2001
39
The tubulointerstitial nephritis and uveitis syndrome. (11738428)
2001
40
Repeat renal biopsy in a girl with tubulointerstitial nephritis and uveitis syndrome. (11685594)
2001
41
Tubulointerstitial nephritis and uveitis syndrome with autoantibody directed to renal tubular cells. (11389273)
2001
42
Tubulointerstitial nephritis and uveitis with bilateral multifocal choroiditis. (10926997)
2000
43
Acute tubulointerstitial nephritis and uveitis with angiotensin-converting enzyme increase. (10529642)
1999
44
Tubulointerstitial nephritis and uveitis in children and adolescents. Four new cases and a review of the literature. (10412864)
1999
45
Tubulointerstitial nephritis and uveitis in association with Epstein-Barr virus infection. (10454786)
1999
46
Tubulointerstitial nephritis and uveitis: an immunological disorder? (7794717)
1995
47
Clinical and immune aspects of idiopathic acute tubulointerstitial nephritis and uveitis syndrome. (7503137)
1995
48
Tubulointerstitial nephritis and uveitis: association with suppressed cellular immunity. (8255514)
1993
49
Syndrome of tubulointerstitial nephritis and uveitis: is it worth considering it as a proper entity? (8367000)
1993
50
Primary tubulointerstitial nephritis and uveitis syndrome. (8148149)
1993

Variations for Tubulointerstitial Nephritis and Uveitis

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Expression for genes affiliated with Tubulointerstitial Nephritis and Uveitis

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Expression patterns in normal tissues for genes affiliated with Tubulointerstitial Nephritis and Uveitis

Search GEO for disease gene expression data for Tubulointerstitial Nephritis and Uveitis.

Pathways for genes affiliated with Tubulointerstitial Nephritis and Uveitis

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Pathways related to Tubulointerstitial Nephritis and Uveitis according to GeneCards/GeneDecks:

(show all 25)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.0HLA-DQA1, HLA-DQB1
2
Show member pathways
8.5HLA-DRB1, HLA-DQA1, HLA-DQB1
3
Show member pathways
8.5HLA-DRB1, HLA-DQA1, HLA-DQB1
4
Show member pathways
8.5HLA-DRB1, HLA-DQA1, HLA-DQB1
58.5HLA-DRB1, HLA-DQA1, HLA-DQB1
6
Show member pathways
8.5HLA-DRB1, HLA-DQA1, HLA-DQB1
7
Show member pathways
8.5HLA-DRB1, HLA-DQA1, HLA-DQB1
8
Show member pathways
8.5HLA-DRB1, HLA-DQA1, HLA-DQB1
9
Show member pathways
8.5HLA-DRB1, HLA-DQA1, HLA-DQB1
10
Show member pathways
8.5HLA-DRB1, HLA-DQA1, HLA-DQB1
11
Show member pathways
8.5HLA-DRB1, HLA-DQA1, HLA-DQB1
12
Show member pathways
Immune response IL 22 signaling pathway60
G protein signaling N RAS regulation pathway60
8.5HLA-DRB1, HLA-DQA1, HLA-DQB1
138.5HLA-DRB1, HLA-DQA1, HLA-DQB1
14
Show member pathways
8.5HLA-DRB1, HLA-DQA1, HLA-DQB1
158.5HLA-DRB1, HLA-DQA1, HLA-DQB1
16
Show member pathways
8.5HLA-DQB1, HLA-DQA1, HLA-DRB1
17
Show member pathways
8.5HLA-DQB1, HLA-DQA1, HLA-DRB1
188.5HLA-DQB1, HLA-DQA1, HLA-DRB1
198.5HLA-DQB1, HLA-DQA1, HLA-DRB1
208.5HLA-DQB1, HLA-DQA1, HLA-DRB1
21
Show member pathways
8.5HLA-DQB1, HLA-DQA1, HLA-DRB1
228.5HLA-DQB1, HLA-DQA1, HLA-DRB1
23
Show member pathways
Immune response T cell receptor signaling pathway60
Immune response CD28 signaling60
Immune response ICOS pathway in T helper cell60
8.5HLA-DQB1, HLA-DQA1, HLA-DRB1
248.5HLA-DQB1, HLA-DQA1, HLA-DRB1
25
Show member pathways
8.5HLA-DQB1, HLA-DQA1, HLA-DRB1

Compounds for genes affiliated with Tubulointerstitial Nephritis and Uveitis

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Sources:
44Novoseek, 50PharmGKB, 11DrugBank
See all sources

Compounds related to Tubulointerstitial Nephritis and Uveitis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1dpa 1449.3HLA-DRB1, HLA-DQA1
2lapatinib44 50 1111.2HLA-DRB1, HLA-DQA1
3aspartate449.0HLA-DQA1, HLA-DQB1
4oligonucleotide448.2HLA-DRB1, HLA-DQA1, HLA-DQB1

GO Terms for genes affiliated with Tubulointerstitial Nephritis and Uveitis

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Cellular components related to Tubulointerstitial Nephritis and Uveitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endosome membraneGO:0100089.0HLA-DQA1, HLA-DQB1
2MHC class II protein complexGO:0426138.7HLA-DQB1, HLA-DQA1, HLA-DRB1
3integral component of lumenal side of endoplasmic reticulum membraneGO:0715568.7HLA-DQB1, HLA-DQA1, HLA-DRB1
4clathrin-coated endocytic vesicle membraneGO:0306698.7HLA-DQA1, HLA-DQB1, HLA-DRB1
5transport vesicle membraneGO:0306588.7HLA-DRB1, HLA-DQA1, HLA-DQB1
6ER to Golgi transport vesicle membraneGO:0125078.6HLA-DRB1, HLA-DQB1, HLA-DQA1
7trans-Golgi network membraneGO:0325888.6HLA-DRB1, HLA-DQA1, HLA-DQB1
8endocytic vesicle membraneGO:0306668.5HLA-DQB1, HLA-DQA1, HLA-DRB1
9lysosomal membraneGO:0057658.4HLA-DRB1, HLA-DQA1, HLA-DQB1
10Golgi membraneGO:0001398.2HLA-DQB1, HLA-DQA1, HLA-DRB1

Biological processes related to Tubulointerstitial Nephritis and Uveitis according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1immunoglobulin production involved in immunoglobulin mediated immune responseGO:0023819.1HLA-DQB1, HLA-DRB1
2humoral immune response mediated by circulating immunoglobulinGO:0024559.0HLA-DQB1, HLA-DRB1
3interferon-gamma-mediated signaling pathwayGO:0603338.7HLA-DQB1, HLA-DQA1, HLA-DRB1
4T cell costimulationGO:0312958.7HLA-DRB1, HLA-DQA1, HLA-DQB1
5T cell receptor signaling pathwayGO:0508528.6HLA-DRB1, HLA-DQA1, HLA-DQB1
6antigen processing and presentation of exogenous peptide antigen via MHC class IIGO:0198868.6HLA-DQB1, HLA-DQA1, HLA-DRB1
7immune responseGO:0069558.5HLA-DQB1, HLA-DRB1, HLA-DQA1
8cytokine-mediated signaling pathwayGO:0192218.2HLA-DRB1, HLA-DQA1, HLA-DQB1

Molecular functions related to Tubulointerstitial Nephritis and Uveitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class II receptor activityGO:0323958.5HLA-DRB1, HLA-DQA1, HLA-DQB1

Products for genes affiliated with Tubulointerstitial Nephritis and Uveitis

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  • Antibodies
  • Proteins
  • Lysates

Sources for Tubulointerstitial Nephritis and Uveitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet