MCID: TBL013
MIFTS: 37

Tubulointerstitial Nephritis and Uveitis malady

Categories: Rare diseases, Eye diseases, Nephrological diseases

Aliases & Classifications for Tubulointerstitial Nephritis and Uveitis

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Sources:
45NIH Rare Diseases, 65UMLS, 51Orphanet, 24GTR, 66UMLS via Orphanet, 28ICD10 via Orphanet, 37MESH via Orphanet
See all MalaCards sources

Aliases & Descriptions for Tubulointerstitial Nephritis and Uveitis:

Name: Tubulointerstitial Nephritis and Uveitis 45 65
Tubulointerstitial Nephritis and Uveitis Syndrome 51 24
Tinu Syndrome 45 51
 
Acute Tubulointerstitial Nephritis and Uveitis Syndrome 51
Tinu 45

Classifications:



External Ids:

Orphanet51 91500
UMLS via Orphanet66 C1639520, C2609298
ICD10 via Orphanet28 N10
MESH via Orphanet37 C536922
UMLS65 C1843273

Summaries for Tubulointerstitial Nephritis and Uveitis

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Wikipedia:68 Tubulointerstitial nephritis and uveitis (TINU) is a rare medical condition in which there is uveitis... more...

MalaCards based summary: Tubulointerstitial Nephritis and Uveitis, also known as tubulointerstitial nephritis and uveitis syndrome, is related to uveitis and choroiditis. An important gene associated with Tubulointerstitial Nephritis and Uveitis is HLA-DQB1 (Major Histocompatibility Complex, Class II, DQ Beta 1), and among its related pathways are Interferon gamma signaling and HTLV-I infection. Affiliated tissues include eye, kidney and prostate.

Related Diseases for Tubulointerstitial Nephritis and Uveitis

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Diseases related to Tubulointerstitial Nephritis and Uveitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 66)
idRelated DiseaseScoreTop Affiliating Genes
1uveitis11.0
2choroiditis10.2
3neuroretinitis10.1
4fanconi syndrome10.1
5thyroiditis10.1
6hyperthyroidism10.1
7focal hand dystonia10.1HLA-DQA1, HLA-DQB1
8duodenum cancer10.1HLA-DQA1, HLA-DQB1
9cogan syndrome10.0
10panuveitis10.0
11graves' disease10.0
12interstitial lung disease10.0
13retinitis10.0
14spondylitis10.0
15lung disease10.0
16iridocyclitis10.0
17acute posterior multifocal placoid pigment epitheliopathy10.0
18multifocal choroiditis10.0
19bullous pemphigoid10.0HLA-DQA1, HLA-DQB1
20autoimmune disease of musculoskeletal system10.0HLA-DQA1, HLA-DQB1
21drug-induced mental disorder9.9HLA-DQA1, HLA-DRB1
22cryptosporidiosis9.9HLA-DQA1, HLA-DRB1
23lichen planus pemphigoides9.9HLA-DQB1, HLA-DRB1
24heavy chain deposition disease9.9HLA-DQB1, HLA-DRB1
25autoimmune polyglandular syndrome type 29.8HLA-DQB1, HLA-DRB1
26best1 retinopathy9.8HLA-DQB1, HLA-DRB1
27idiopathic juxtafoveal retinal telangiectasia9.8HLA-DQB1, HLA-DRB1
28neurotic excoriation9.8HLA-DQA1, HLA-DQB1
29non-distal monosomy 10q9.8HLA-DQB1, HLA-DRB1
30lichtenstein syndrome9.8HLA-DQB1, HLA-DRB1
31red cell phospholipid defect with hemolysis9.8HLA-DQB1, HLA-DRB1
32psoriasis9.8HLA-DQB1, HLA-DRB1
33actinomycosis9.8HLA-DQB1, HLA-DRB1
34finnish upper limb-onset distal myopathy9.8HLA-DQB1, HLA-DRB1
35nut allergy9.8HLA-DQB1, HLA-DRB1
36lymphocytic choriomeningitis9.8HLA-DQB1, HLA-DRB1
37moderately severe hemophilia a9.8HLA-DQB1, HLA-DRB1
38angioid streaks9.8HLA-DQB1, HLA-DRB1
39cytoplasmic body myopathy9.8HLA-DQB1, HLA-DRB1
40hypertonia9.8HLA-DQB1, HLA-DRB1
41bipolar ll disorder9.8HLA-DQB1, HLA-DRB1
42hepatoid adenocarcinoma9.8HLA-DQB1, HLA-DRB1
43bubonic plague9.7HLA-DQB1, HLA-DRB1
44kernicterus due to isoimmunization9.7HLA-DQB1, HLA-DRB1
45gerstmann-straussler disease9.7HLA-DQA1, HLA-DQB1
46sarcoidosis 19.7HLA-DQA1, HLA-DQB1
47ichthyosis-hypotrichosis-sclerosing cholangitis syndrome9.7HLA-DQB1, HLA-DRB1
48byssinosis9.7HLA-DQB1, HLA-DRB1
49human spumaretrovirus infection9.7HLA-DQB1, HLA-DRB1
50thyrotoxic exophthalmos9.6HLA-DQA1, HLA-DQB1

Graphical network of the top 20 diseases related to Tubulointerstitial Nephritis and Uveitis:



Diseases related to tubulointerstitial nephritis and uveitis

Symptoms for Tubulointerstitial Nephritis and Uveitis

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Drugs & Therapeutics for Tubulointerstitial Nephritis and Uveitis

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Tubulointerstitial Nephritis and Uveitis

Genetic Tests for Tubulointerstitial Nephritis and Uveitis

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Anatomical Context for Tubulointerstitial Nephritis and Uveitis

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MalaCards organs/tissues related to Tubulointerstitial Nephritis and Uveitis:

33
Eye, Kidney, Prostate, Lung, Skin, T cells, Monocytes

Animal Models for Tubulointerstitial Nephritis and Uveitis or affiliated genes

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Publications for Tubulointerstitial Nephritis and Uveitis

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Articles related to Tubulointerstitial Nephritis and Uveitis:

(show top 50)    (show all 96)
idTitleAuthorsYear
1
TUBULOINTERSTITIAL NEPHRITIS AND UVEITIS SYNDROME WITH A PRIMARY PRESENTATION OF ACUTE POSTERIOR MULTIFOCAL PLACOID PIGMENT EPITHELIOPATHY. (26967965)
2016
2
Lamotrigine-induced tubulointerstitial nephritis and uveitis-atypical Cogan syndrome. (26350991)
2015
3
A report of an adult case of tubulointerstitial nephritis and uveitis (TINU) syndrome, with a review of 102 Japanese cases. (25725230)
2015
4
Choroidal neovascularization secondary to tubulointerstitial nephritis and uveitis syndrome (TINU) in an adult patient. (26446047)
2015
5
Tubulointerstitial Nephritis and Uveitis Syndrome: Case Report and Review of the Literature. (26400208)
2015
6
Tubulointerstitial Nephritis and Uveitis Syndrome with non caseating granuloma in bone marrow biopsy. (24813498)
2014
7
Neuroretinitis: a rare feature of tubulointerstitial nephritis and uveitis syndrome. (23824660)
2013
8
HLA-DR, DQ Class II DNA Typing in Pediatric Panuveitis and Tubulointerstitial Nephritis and Uveitis (TINU). (24321473)
2013
9
A boy with IgA nephropathy complicated by tubulointerstitial nephritis and uveitis (TINU) syndrome. (24075025)
2013
10
Tubulointerstitial nephritis and uveitis syndrome in an older adult: a case report and review of the literature. (24117310)
2013
11
Moth-eaten appearance of tubulointerstitial nephritis and uveitis syndrome on (99m)technetium dimercaptosuccinic acid scintigraphy. (23092525)
2013
12
Two cases of subfoveal choroidal neovascularization with tubulointerstitial nephritis and uveitis syndrome. (23335312)
2013
13
Tubulointerstitial nephritis and uveitis syndrome in a twelve-year-old girl. (23691408)
2013
14
Excellent outcome of tubulointerstitial nephritis and uveitis: case report and five-year follow-up. (22681193)
2012
15
Tubulointerstitial nephritis and uveitis: report of a rare syndrome. (21189439)
2011
16
Tubulointerstitial nephritis and uveitis syndrome with transient hyperthyroidism in an elderly patient. (21823045)
2011
17
Recurrent tubulointerstitial nephritis and uveitis syndrome in a renal transplant recipient. (21673077)
2011
18
Tubulointerstitial nephritis and uveitis (TINU) syndrome caused by the Chinese herb "Goreisan". (18661195)
2009
19
Short course of cyclophosphamide therapy may reduce recurrence in patients with tubulointerstitial nephritis and uveitis syndrome. (19587511)
2009
20
A Case of Tubulointerstitial Nephritis and Uveitis (TINU) Syndrome with High ASLO Titer. (24179369)
2009
21
Is tubulointerstitial nephritis and uveitis syndrome associated with IgG4-related systemic disease? (18199112)
2008
22
Tubulointerstitial nephritis and uveitis syndrome (TINU): a step forward to understanding an elusive oculorenal syndrome. (18272778)
2008
23
Recurrent and progressive nephritis in a patient with acute tubulointerstitial nephritis and uveitis syndrome. (18218320)
2008
24
Human leucocyte antigen DQ alpha heterodimers and human leucocyte antigen DR alleles in tubulointerstitial nephritis and uveitis syndrome. (19154326)
2008
25
Presence of autoantibodies against tubular and uveal cells in a patient with tubulointerstitial nephritis and uveitis (TINU) syndrome. (18156461)
2008
26
Tubulointerstitial nephritis and uveitis syndrome in a mother and her son. (18528711)
2008
27
Tubulointerstitial nephritis and uveitis syndrome. (18427256)
2008
28
Enhanced recognition, treatment, and prognosis of tubulointerstitial nephritis and uveitis syndrome. (17383731)
2007
29
Lymphoid interstitial lung disease in a patient with acute tubulointerstitial nephritis and uveitis: a new facet of a rare syndrome? (16564933)
2006
30
Elevation of serum Krebs von den Lunge-6 levels in patients with tubulointerstitial nephritis and uveitis syndrome. (17162148)
2006
31
Adult onset tubulointerstitial nephritis and uveitis syndrome. (16109092)
2005
32
A case of tubulointerstitial nephritis and uveitis syndrome with severe immunologic dysregulation. (16208535)
2005
33
Tubulointerstitial nephritis and uveitis syndrome (TINU syndrome) with unilateral neuroretinitis: a case report. (15309980)
2004
34
Strong associations between specific HLA-DQ and HLA-DR alleles and the tubulointerstitial nephritis and uveitis syndrome. (12556395)
2003
35
A case of adult-onset tubulointerstitial nephritis and uveitis ("TINU syndrome") associated with sacroileitis and Epstein-Barr virus infection with good spontaneous outcome. (12955704)
2003
36
The tubulointerstitial nephritis and uveitis syndrome. (12052421)
2002
37
Tubulointerstitial nephritis and uveitis syndrome. (11698749)
2001
38
Tubulointerstitial nephritis and uveitis syndrome in two siblings. (11556736)
2001
39
The tubulointerstitial nephritis and uveitis syndrome. (11738428)
2001
40
Repeat renal biopsy in a girl with tubulointerstitial nephritis and uveitis syndrome. (11685594)
2001
41
Tubulointerstitial nephritis and uveitis syndrome with autoantibody directed to renal tubular cells. (11389273)
2001
42
Tubulointerstitial nephritis and uveitis with bilateral multifocal choroiditis. (10926997)
2000
43
Acute tubulointerstitial nephritis and uveitis with angiotensin-converting enzyme increase. (10529642)
1999
44
Tubulointerstitial nephritis and uveitis in children and adolescents. Four new cases and a review of the literature. (10412864)
1999
45
Tubulointerstitial nephritis and uveitis in association with Epstein-Barr virus infection. (10454786)
1999
46
Tubulointerstitial nephritis and uveitis: an immunological disorder? (7794717)
1995
47
Clinical and immune aspects of idiopathic acute tubulointerstitial nephritis and uveitis syndrome. (7503137)
1995
48
Tubulointerstitial nephritis and uveitis: association with suppressed cellular immunity. (8255514)
1993
49
Syndrome of tubulointerstitial nephritis and uveitis: is it worth considering it as a proper entity? (8367000)
1993
50
Primary tubulointerstitial nephritis and uveitis syndrome. (8148149)
1993

Variations for Tubulointerstitial Nephritis and Uveitis

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Expression for genes affiliated with Tubulointerstitial Nephritis and Uveitis

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Search GEO for disease gene expression data for Tubulointerstitial Nephritis and Uveitis.

Pathways for genes affiliated with Tubulointerstitial Nephritis and Uveitis

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Pathways related to Tubulointerstitial Nephritis and Uveitis according to GeneCards Suite gene sharing:

(show all 22)
idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
8.5HLA-DQA1, HLA-DQB1, HLA-DRB1
28.5HLA-DQA1, HLA-DQB1, HLA-DRB1
3
Show member pathways
8.5HLA-DQA1, HLA-DQB1, HLA-DRB1
4
Show member pathways
8.5HLA-DQA1, HLA-DQB1, HLA-DRB1
5
Show member pathways
8.5HLA-DQA1, HLA-DQB1, HLA-DRB1
6
Show member pathways
8.5HLA-DQA1, HLA-DQB1, HLA-DRB1
7
Show member pathways
8.5HLA-DQA1, HLA-DQB1, HLA-DRB1
8
Show member pathways
8.5HLA-DQA1, HLA-DQB1, HLA-DRB1
9
Show member pathways
8.5HLA-DQA1, HLA-DQB1, HLA-DRB1
10
Show member pathways
8.5HLA-DQA1, HLA-DQB1, HLA-DRB1
118.5HLA-DQA1, HLA-DQB1, HLA-DRB1
12
Show member pathways
8.5HLA-DQA1, HLA-DQB1, HLA-DRB1
13
Show member pathways
8.5HLA-DQA1, HLA-DQB1, HLA-DRB1
148.5HLA-DQA1, HLA-DQB1, HLA-DRB1
158.5HLA-DQA1, HLA-DQB1, HLA-DRB1
168.5HLA-DQA1, HLA-DQB1, HLA-DRB1
178.5HLA-DQA1, HLA-DQB1, HLA-DRB1
188.5HLA-DQA1, HLA-DQB1, HLA-DRB1
19
Show member pathways
8.5HLA-DQA1, HLA-DQB1, HLA-DRB1
208.5HLA-DQA1, HLA-DQB1, HLA-DRB1
21
Show member pathways
8.5HLA-DQA1, HLA-DQB1, HLA-DRB1
228.5HLA-DQA1, HLA-DQB1, HLA-DRB1

GO Terms for genes affiliated with Tubulointerstitial Nephritis and Uveitis

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Cellular components related to Tubulointerstitial Nephritis and Uveitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1MHC class II protein complexGO:00426139.8HLA-DQA1, HLA-DQB1
2integral component of lumenal side of endoplasmic reticulum membraneGO:00715569.7HLA-DQA1, HLA-DQB1
3endosome membraneGO:00100089.3HLA-DQA1, HLA-DQB1
4ER to Golgi transport vesicle membraneGO:00125078.5HLA-DQA1, HLA-DQB1, HLA-DRB1
5trans-Golgi network membraneGO:00325888.4HLA-DQA1, HLA-DQB1, HLA-DRB1

Biological processes related to Tubulointerstitial Nephritis and Uveitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1antigen processing and presentation of peptide or polysaccharide antigen via MHC class IIGO:00025049.6HLA-DQA1, HLA-DRB1
2immunoglobulin production involved in immunoglobulin mediated immune responseGO:00023819.5HLA-DQB1, HLA-DRB1
3cytokine-mediated signaling pathwayGO:00192219.1HLA-DQA1, HLA-DRB1
4antigen processing and presentationGO:00198828.7HLA-DQA1, HLA-DQB1, HLA-DRB1

Sources for Tubulointerstitial Nephritis and Uveitis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet