MCID: TBL013
MIFTS: 33

Tubulointerstitial Nephritis and Uveitis malady

Rare diseases, Eye diseases, Nephrological diseases categories

Aliases & Classifications for Tubulointerstitial Nephritis and Uveitis

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Sources:
45NIH Rare Diseases, 65UMLS, 51Orphanet, 66UMLS via Orphanet, 28ICD10 via Orphanet, 37MESH via Orphanet
See all sources

Aliases & Descriptions for Tubulointerstitial Nephritis and Uveitis:

Name: Tubulointerstitial Nephritis and Uveitis 45 65
Tinu Syndrome 45 51
Acute Tubulointerstitial Nephritis and Uveitis Syndrome 51
 
Tubulointerstitial Nephritis and Uveitis Syndrome 51
Tinu 45


Classifications:



External Ids:

Orphanet51 91500
UMLS via Orphanet66 C1639520, C2609298
ICD10 via Orphanet28 N10
MESH via Orphanet37 C536922

Summaries for Tubulointerstitial Nephritis and Uveitis

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Wikipedia:68 Tubulointerstitial nephritis and uveitis (TINU) is a rare medical condition in which there is uveitis... more...

MalaCards based summary: Tubulointerstitial Nephritis and Uveitis, also known as tinu syndrome, is related to uveitis and choroiditis. An important gene associated with Tubulointerstitial Nephritis and Uveitis is HLA-DQB1 (Major Histocompatibility Complex, Class II, DQ Beta 1), and among its related pathways are Immune response NFAT in immune response and Interferon gamma signaling. Affiliated tissues include eye, kidney and bone.

Related Diseases for Tubulointerstitial Nephritis and Uveitis

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Diseases related to Tubulointerstitial Nephritis and Uveitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 72)
idRelated DiseaseScoreTop Affiliating Genes
1uveitis11.3
2choroiditis10.6
3fanconi syndrome10.5
4neuroretinitis10.5
5hyperthyroidism10.5
6thyroiditis10.5
7interstitial nephritis10.4
8graves' disease10.4
9cogan syndrome10.4
10interstitial lung disease10.4
11iridocyclitis10.4
12panuveitis10.4
13retinitis10.4
14spondylitis10.4
15multifocal choroiditis10.4
16anterior uveitis10.2
17hepatitis10.0
18granulomatous hepatitis10.0
19posterior uveitis10.0
20chorioretinal scar10.0
21chorioretinitis10.0
22scleritis10.0
23intermediate anorectal malformation10.0HLA-DQA1, HLA-DQB1
24endophthalmitis10.0HLA-DQA1, HLA-DQB1
25dermatomycosis10.0HLA-DQA1, HLA-DQB1
26autoimmune disease of skin and connective tissue10.0HLA-DQA1, HLA-DQB1
27conn's syndrome10.0HLA-DQA1, HLA-DRB1
28hordeolum10.0HLA-DQA1, HLA-DRB1
29best1 retinopathy9.9HLA-DQB1, HLA-DRB1
30lichen planus pemphigoides9.9HLA-DQB1, HLA-DRB1
31microsomia hemifacial radial defects9.9HLA-DQB1, HLA-DRB1
32celiac disease9.9HLA-DQA1, HLA-DQB1
33heavy chain deposition disease9.9HLA-DQB1, HLA-DRB1
34autoimmune polyglandular syndrome type 29.9HLA-DQB1, HLA-DRB1
35red cell phospholipid defect with hemolysis9.9HLA-DQB1, HLA-DRB1
36childhood cerebellar astrocytic neoplasm9.9HLA-DQB1, HLA-DRB1
37finnish upper limb-onset distal myopathy9.9HLA-DQB1, HLA-DRB1
38senile atrophy of choroid9.9HLA-DQB1, HLA-DRB1
39microsporidiosis9.9HLA-DQB1, HLA-DRB1
40glucosephosphate dehydrogenase deficiency9.9HLA-DQA1, HLA-DQB1
41moderately severe hemophilia a9.9HLA-DQB1, HLA-DRB1
42cytoplasmic body myopathy9.9HLA-DQB1, HLA-DRB1
43ocular melanoma9.9HLA-DQB1, HLA-DRB1
44papillary adenocarcinoma9.9HLA-DQB1, HLA-DRB1
45hypertonia9.9HLA-DQB1, HLA-DRB1
46histidinemia9.9HLA-DQB1, HLA-DRB1
47limited scleroderma9.9HLA-DQB1, HLA-DRB1
48baritosis9.9HLA-DQB1, HLA-DRB1
49human spumaretrovirus infection9.9HLA-DQB1, HLA-DRB1
50ichthyosis - hypotrichosis - sclerosing cholangitis9.9HLA-DQB1, HLA-DRB1

Graphical network of the top 20 diseases related to Tubulointerstitial Nephritis and Uveitis:



Diseases related to tubulointerstitial nephritis and uveitis

Symptoms for Tubulointerstitial Nephritis and Uveitis

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Drugs & Therapeutics for Tubulointerstitial Nephritis and Uveitis

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Tubulointerstitial Nephritis and Uveitis

Genetic Tests for Tubulointerstitial Nephritis and Uveitis

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Anatomical Context for Tubulointerstitial Nephritis and Uveitis

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MalaCards organs/tissues related to Tubulointerstitial Nephritis and Uveitis:

33
Eye, Kidney, Bone, Thyroid, Lung, Bone marrow

Animal Models for Tubulointerstitial Nephritis and Uveitis or affiliated genes

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Publications for Tubulointerstitial Nephritis and Uveitis

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Articles related to Tubulointerstitial Nephritis and Uveitis:

(show top 50)    (show all 90)
idTitleAuthorsYear
1
Lamotrigine-induced tubulointerstitial nephritis and uveitis-atypical Cogan syndrome. (26350991)
2015
2
A report of an adult case of tubulointerstitial nephritis and uveitis (TINU) syndrome, with a review of 102 Japanese cases. (25725230)
2015
3
Choroidal neovascularization secondary to tubulointerstitial nephritis and uveitis syndrome (TINU) in an adult patient. (26446047)
2015
4
Tubulointerstitial Nephritis and Uveitis Syndrome: Case Report and Review of the Literature. (26400208)
2015
5
Acute granulomatous iridocyclitis in a child with tubulointerstitial nephritis and uveitis syndrome. (25861394)
2015
6
Tubulointerstitial Nephritis and Uveitis Syndrome with non caseating granuloma in bone marrow biopsy. (24813498)
2014
7
Neuroretinitis: a rare feature of tubulointerstitial nephritis and uveitis syndrome. (23824660)
2013
8
HLA-DR, DQ Class II DNA Typing in Pediatric Panuveitis and Tubulointerstitial Nephritis and Uveitis (TINU). (24321473)
2013
9
A boy with IgA nephropathy complicated by tubulointerstitial nephritis and uveitis (TINU) syndrome. (24075025)
2013
10
Tubulointerstitial nephritis and uveitis syndrome in an older adult: a case report and review of the literature. (24117310)
2013
11
Moth-eaten appearance of tubulointerstitial nephritis and uveitis syndrome on (99m)technetium dimercaptosuccinic acid scintigraphy. (23092525)
2013
12
Two cases of subfoveal choroidal neovascularization with tubulointerstitial nephritis and uveitis syndrome. (23335312)
2013
13
Tubulointerstitial nephritis and uveitis syndrome in a twelve-year-old girl. (23691408)
2013
14
Excellent outcome of tubulointerstitial nephritis and uveitis: case report and five-year follow-up. (22681193)
2012
15
TINU (tubulointerstitial nephritis and uveitis) syndrome is not usually associated with IgG4 sclerosing disease. (22277743)
2012
16
Tubulointerstitial nephritis and uveitis: report of a rare syndrome. (21189439)
2011
17
Tubulointerstitial nephritis and uveitis syndrome with transient hyperthyroidism in an elderly patient. (21823045)
2011
18
Recurrent tubulointerstitial nephritis and uveitis syndrome in a renal transplant recipient. (21673077)
2011
19
Tubulointerstitial nephritis and uveitis (TINU) syndrome caused by the Chinese herb "Goreisan". (18661195)
2009
20
Short course of cyclophosphamide therapy may reduce recurrence in patients with tubulointerstitial nephritis and uveitis syndrome. (19587511)
2009
21
A Case of Tubulointerstitial Nephritis and Uveitis (TINU) Syndrome with High ASLO Titer. (24179369)
2009
22
Syndrome of tubulointerstitial nephritis and uveitis. (19582990)
2009
23
Is tubulointerstitial nephritis and uveitis syndrome associated with IgG4-related systemic disease? (18199112)
2008
24
Tubulointerstitial nephritis and uveitis syndrome (TINU): a step forward to understanding an elusive oculorenal syndrome. (18272778)
2008
25
Recurrent and progressive nephritis in a patient with acute tubulointerstitial nephritis and uveitis syndrome. (18218320)
2008
26
Human leucocyte antigen DQ alpha heterodimers and human leucocyte antigen DR alleles in tubulointerstitial nephritis and uveitis syndrome. (19154326)
2008
27
Presence of autoantibodies against tubular and uveal cells in a patient with tubulointerstitial nephritis and uveitis (TINU) syndrome. (18156461)
2008
28
Tubulointerstitial nephritis and uveitis syndrome in a mother and her son. (18528711)
2008
29
Enhanced recognition, treatment, and prognosis of tubulointerstitial nephritis and uveitis syndrome. (17383731)
2007
30
Lymphoid interstitial lung disease in a patient with acute tubulointerstitial nephritis and uveitis: a new facet of a rare syndrome? (16564933)
2006
31
Elevation of serum Krebs von den Lunge-6 levels in patients with tubulointerstitial nephritis and uveitis syndrome. (17162148)
2006
32
Adult onset tubulointerstitial nephritis and uveitis syndrome. (16109092)
2005
33
A case of tubulointerstitial nephritis and uveitis syndrome with severe immunologic dysregulation. (16208535)
2005
34
Tubulointerstitial nephritis and uveitis syndrome (TINU syndrome) with unilateral neuroretinitis: a case report. (15309980)
2004
35
Strong associations between specific HLA-DQ and HLA-DR alleles and the tubulointerstitial nephritis and uveitis syndrome. (12556395)
2003
36
A case of adult-onset tubulointerstitial nephritis and uveitis ("TINU syndrome") associated with sacroileitis and Epstein-Barr virus infection with good spontaneous outcome. (12955704)
2003
37
The tubulointerstitial nephritis and uveitis syndrome. (12052421)
2002
38
Tubulointerstitial nephritis and uveitis syndrome. (11698749)
2001
39
Tubulointerstitial nephritis and uveitis syndrome in two siblings. (11556736)
2001
40
The tubulointerstitial nephritis and uveitis syndrome. (11738428)
2001
41
Repeat renal biopsy in a girl with tubulointerstitial nephritis and uveitis syndrome. (11685594)
2001
42
Tubulointerstitial nephritis and uveitis syndrome with autoantibody directed to renal tubular cells. (11389273)
2001
43
Tubulointerstitial nephritis and uveitis with bilateral multifocal choroiditis. (10926997)
2000
44
Acute tubulointerstitial nephritis and uveitis with angiotensin-converting enzyme increase. (10529642)
1999
45
Tubulointerstitial nephritis and uveitis in children and adolescents. Four new cases and a review of the literature. (10412864)
1999
46
Tubulointerstitial nephritis and uveitis: an immunological disorder? (7794717)
1995
47
Clinical and immune aspects of idiopathic acute tubulointerstitial nephritis and uveitis syndrome. (7503137)
1995
48
Tubulointerstitial nephritis and uveitis: association with suppressed cellular immunity. (8255514)
1993
49
Syndrome of tubulointerstitial nephritis and uveitis: is it worth considering it as a proper entity? (8367000)
1993
50
Primary tubulointerstitial nephritis and uveitis syndrome. (8148149)
1993

Variations for Tubulointerstitial Nephritis and Uveitis

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Expression for genes affiliated with Tubulointerstitial Nephritis and Uveitis

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Search GEO for disease gene expression data for Tubulointerstitial Nephritis and Uveitis.

Pathways for genes affiliated with Tubulointerstitial Nephritis and Uveitis

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Pathways related to Tubulointerstitial Nephritis and Uveitis according to GeneCards Suite gene sharing:

(show all 23)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
8.5HLA-DQA1, HLA-DQB1, HLA-DRB1
2
Show member pathways
8.5HLA-DQA1, HLA-DQB1, HLA-DRB1
38.5HLA-DQA1, HLA-DQB1, HLA-DRB1
4
Show member pathways
8.5HLA-DQA1, HLA-DQB1, HLA-DRB1
5
Show member pathways
8.5HLA-DQA1, HLA-DQB1, HLA-DRB1
6
Show member pathways
8.5HLA-DQA1, HLA-DQB1, HLA-DRB1
7
Show member pathways
8.5HLA-DQA1, HLA-DQB1, HLA-DRB1
8
Show member pathways
8.5HLA-DQA1, HLA-DQB1, HLA-DRB1
9
Show member pathways
8.5HLA-DQA1, HLA-DQB1, HLA-DRB1
10
TCR Signaling (Qiagen)
Show member pathways
8.5HLA-DQA1, HLA-DQB1, HLA-DRB1
11
TCR signaling (REACTOME)
Show member pathways
8.5HLA-DQA1, HLA-DQB1, HLA-DRB1
128.5HLA-DQA1, HLA-DQB1, HLA-DRB1
13
Show member pathways
8.5HLA-DQA1, HLA-DQB1, HLA-DRB1
148.5HLA-DQA1, HLA-DQB1, HLA-DRB1
158.5HLA-DQA1, HLA-DQB1, HLA-DRB1
168.5HLA-DQA1, HLA-DQB1, HLA-DRB1
178.5HLA-DQA1, HLA-DQB1, HLA-DRB1
188.5HLA-DQA1, HLA-DQB1, HLA-DRB1
19
Show member pathways
8.5HLA-DQA1, HLA-DQB1, HLA-DRB1
20
Show member pathways
8.5HLA-DQA1, HLA-DQB1, HLA-DRB1
218.5HLA-DQA1, HLA-DQB1, HLA-DRB1
22
Show member pathways
8.5HLA-DQA1, HLA-DQB1, HLA-DRB1
238.5HLA-DQA1, HLA-DQB1, HLA-DRB1

GO Terms for genes affiliated with Tubulointerstitial Nephritis and Uveitis

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Cellular components related to Tubulointerstitial Nephritis and Uveitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1endosome membraneGO:00100089.6HLA-DQA1, HLA-DQB1
2MHC class II protein complexGO:00426138.9HLA-DQA1, HLA-DQB1, HLA-DRB1
3integral component of lumenal side of endoplasmic reticulum membraneGO:00715568.9HLA-DQA1, HLA-DQB1, HLA-DRB1
4ER to Golgi transport vesicle membraneGO:00125078.9HLA-DQA1, HLA-DQB1, HLA-DRB1
5endocytic vesicle membraneGO:00306668.9HLA-DQA1, HLA-DQB1, HLA-DRB1
6clathrin-coated endocytic vesicle membraneGO:00306698.8HLA-DQA1, HLA-DQB1, HLA-DRB1
7trans-Golgi network membraneGO:00325888.8HLA-DQA1, HLA-DQB1, HLA-DRB1
8lysosomal membraneGO:00057658.6HLA-DQA1, HLA-DQB1, HLA-DRB1
9Golgi membraneGO:00001398.5HLA-DQA1, HLA-DQB1, HLA-DRB1
10transport vesicle membraneGO:00306588.4HLA-DQA1, HLA-DQB1, HLA-DRB1

Biological processes related to Tubulointerstitial Nephritis and Uveitis according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1immunoglobulin production involved in immunoglobulin mediated immune responseGO:00023819.6HLA-DQB1, HLA-DRB1
2humoral immune response mediated by circulating immunoglobulinGO:00024559.5HLA-DQB1, HLA-DRB1
3antigen processing and presentation of peptide or polysaccharide antigen via MHC class IIGO:00025049.1HLA-DQA1, HLA-DQB1, HLA-DRB1
4interferon-gamma-mediated signaling pathwayGO:00603339.0HLA-DQA1, HLA-DQB1, HLA-DRB1
5T cell costimulationGO:00312958.9HLA-DQA1, HLA-DQB1, HLA-DRB1
6antigen processing and presentationGO:00198828.9HLA-DQA1, HLA-DQB1, HLA-DRB1
7T cell receptor signaling pathwayGO:00508528.9HLA-DQA1, HLA-DQB1, HLA-DRB1
8antigen processing and presentation of exogenous peptide antigen via MHC class IIGO:00198868.6HLA-DQA1, HLA-DQB1, HLA-DRB1
9cytokine-mediated signaling pathwayGO:00192218.5HLA-DQA1, HLA-DQB1, HLA-DRB1
10immune responseGO:00069558.4HLA-DQA1, HLA-DQB1, HLA-DRB1

Molecular functions related to Tubulointerstitial Nephritis and Uveitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1MHC class II receptor activityGO:00323958.7HLA-DQA1, HLA-DQB1, HLA-DRB1
2peptide antigen bindingGO:00426058.5HLA-DQA1, HLA-DQB1, HLA-DRB1

Sources for Tubulointerstitial Nephritis and Uveitis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet