MCID: TFT001
MIFTS: 47

Tufted Angioma malady

Rare diseases, Cardiovascular diseases, Fetal diseases categories
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Summaries for Tufted Angioma

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Wikipedia:65 A tufted angioma (also known as an \"Acquired tufted angioma,\" \"Angioblastoma,\" \"Angioblastoma of... more...

MalaCards based summary: Tufted Angioma, also known as nakagawa angioblastoma, is related to hemangioendothelioma and pyogenic granuloma, and has symptoms including An important gene associated with Tufted Angioma is FLT4 (fms-related tyrosine kinase 4), and among its related pathways are Akt Signaling Pathway and Tyrosine Kinases / Adaptors. The compounds regorafenib and agar have been mentioned in the context of this disorder. Affiliated tissues include liver and endothelial, and related mouse phenotypes are muscle and normal.

Description from OMIM:46 607859

Aliases & Classifications for Tufted Angioma

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Sources:
42NIH Rare Diseases, 48Orphanet, 46OMIM, 62UMLS, 44Novoseek, 35MESH via Orphanet, 26ICD10 via Orphanet, 63UMLS via Orphanet
See all sources

Tufted Angioma, Aliases & Descriptions:

Name: Tufted Angioma 42 48 46 62
Nakagawa Angioblastoma 48
 
Angioma, Tufted 44
Angioma Tufted 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Fetal diseases
Anatomical: Cardiovascular diseases


Characteristics (Orphanet epidemiological data):

48
tufted angioma:
Inheritance: Multigenic/multifactorial,Sporadic; Age of onset: Childhood; Age of death: Normal


External Ids:

OMIM46 607859
MESH via Orphanet35 C536924
ICD10 via Orphanet26 D18.0
UMLS via Orphanet63 C0346073

Related Diseases for Tufted Angioma

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Diseases related to Tufted Angioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 50)
idRelated DiseaseScoreTop Affiliating Genes
1hemangioendothelioma31.0FLT4, IFNA2
2pyogenic granuloma30.6TEK, FLT4
3angiosarcoma30.6FLT4, TEK
4sarcoma30.4TEK, FLT4, ENG
5kaposi's sarcoma30.3TEK, FLT4, IFNA2
6hemangioma30.0IFNA2, PROX1, FLT4, TEK
7kaposiform hemangioendothelioma10.6
8lymphangiosarcoma10.5PROX1
9klippel-trenaunay syndrome10.4FLT4
10lymphangioma10.2PROX1, FLT4
11inflammatory breast carcinoma10.2PROX1, TEK
12lymphedema10.2PROX1, FLT4
13myofascial pain syndrome10.2
14neurofibromatosis10.2
15herpes zoster10.2
16arteriovenous malformation10.2
17capillary hemangioma10.2
18cavernous hemangioma10.2
19hemangioma thrombocytopenia syndrome10.2
20endotheliitis10.2
21intracranial hemorrhage in brain cerebrovascular malformations10.2TEK, ENG
22vascular cancer10.1FLT4, ENG
23laryngeal benign neoplasm10.1ENG, FLT4
24non-small cell lung carcinoma10.1FLT4, TEK
25papillary thyroid carcinoma10.1ENG, TEK
26epithelioid hemangioendothelioma10.1FLT4, IFNA2
27papilloma10.1IFNA2, FLT4
28endometriosis10.1TEK, ENG
29proteinuria10.0TEK, ENG
30pancreatic cancer10.0ENG, FLT4
31vascular disease10.0TEK, ENG
32bone marrow cancer10.0ENG, IFNA2
33pre-eclampsia10.0ENG, TEK
34coronary artery anomaly10.0ENG, TEK
35hepatitis c10.0ENG, IFNA2
36endometrial carcinoma9.9TEK, FLT4, ENG
37glioblastoma9.9TEK, FLT4, ENG
38stomach cancer9.9ENG, FLT4, TEK
39breast cancer9.9TEK, FLT4, ENG
40malignant glioma9.9ENG, FLT4, TEK
41tongue squamous cell carcinoma9.9TEK, FLT4, ENG
42adenocarcinoma9.8ENG, FLT4, TEK
43chronic myeloid leukemia9.8ENG, IFNA2
44prostate cancer9.8ENG, FLT4, TEK
45colorectal cancer9.8ENG, IFNA2, FLT4
46liver cancer9.7TEK, IFNA2, ENG
47deficiency anemia9.7ENG, IFNA2
48kidney cancer9.6ENG, IFNA2, FLT4, TEK
49melanoma9.6ENG, IFNA2, FLT4, TEK
50leukemia9.6ENG, IFNA2, FLT4, TEK

Graphical network of the top 20 diseases related to Tufted Angioma:



Diseases related to tufted angioma

Symptoms for Tufted Angioma

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Symptoms by clinical synopsis from OMIM:

607859

Clinical features from OMIM:

607859

HPO human phenotypes related to Tufted Angioma:

id Description Frequency HPO Source Accession
1 autosomal dominant inheritance HP:0000006
2 abnormality of skin pigmentation HP:0001000
3 incomplete penetrance HP:0003829
4 vascular skin abnormality HP:0011276
5 tufted angioma HP:0012329

Drugs & Therapeutics for Tufted Angioma

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Drug clinical trials:

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Search NIH Clinical Center for Tufted Angioma

Genetic Tests for Tufted Angioma

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Anatomical Context for Tufted Angioma

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MalaCards organs/tissues related to Tufted Angioma:

32
Liver, Endothelial

Animal Models for Tufted Angioma or affiliated genes

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MGI Mouse Phenotypes related to Tufted Angioma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.7ENG, FLT4, TEK
2MP:00028738.2ENG, PROX1, FLT4, TEK
3MP:00053858.2TEK, FLT4, PROX1, ENG
4MP:00053788.1TEK, FLT4, PROX1, ENG
5MP:00053767.9ENG, PROX1, FLT4, TEK

Publications for Tufted Angioma

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Articles related to Tufted Angioma:

(show top 50)    (show all 90)
idTitleAuthorsYear
1
Kasabach-Merritt phenomenon in an adult man with a tufted angioma and cirrhosis responding to radiation, bevacizumab, and prednisone. (24697614)
2014
2
Tufted angioma of the face. (23706996)
2013
3
Tufted angioma arising at a site of BCG vaccination. (23238237)
2013
4
Resection of a huge tufted angioma of orbit and orbitocranial mesh reconstruction. (23700166)
2013
5
An acquired tufted angioma of the nasal cavity. (23518006)
2013
6
Acquired tufted angioma in pregnancy showing expression of estrogen and progesterone receptors. (24185824)
2013
7
Acquired capillary hemangioma with features of tufted angioma in the external auditory canal. (23714987)
2013
8
Tufted angioma (Angioblastoma) of eyelid in adults-report of two cases. (24044498)
2013
9
Acquired tufted angioma of upper lip: case report and review of the literature. (23526035)
2013
10
Variable response to propranolol treatment of kaposiform hemangioendothelioma, tufted angioma, and Kasabach-Merritt phenomenon. (22648868)
2012
11
Tufted angioma and myofascial pain syndrome. (21437533)
2011
12
Kasabach-merritt syndrome arising from tufted angioma successfully treated with systemic corticosteroid. (21165213)
2010
13
Expression of prox1, lymphatic endothelial nuclear transcription factor, in Kaposiform hemangioendothelioma and tufted angioma. (20975337)
2010
14
Congenital tufted angioma: Case report and review of the literature. (20492819)
2010
15
Tufted angioma associated with Kasabach-Merritt phenomenon: a therapeutic challenge. (20814640)
2010
16
Tufted angioma presented with segmental hyperpigmented plaque in a young Chinese woman. (20175859)
2010
17
Extensive tufted angioma of the left arm in a 47-year-old woman. (19323667)
2009
18
Tufted angioma. (19061619)
2008
19
Tufted angioma-associated Kasabach-Merritt syndrome treated with embolization and vincristine. (18301012)
2008
20
Treatment of a tufted angioma with intense pulsed light. (17520468)
2007
21
Usefulness of D2-40 immunohistochemistry for differentiation between kaposiform hemangioendothelioma and tufted angioma. (16872472)
2006
22
Congenital, self-regressing tufted angioma. (16785378)
2006
23
Tufted angioma. (16409274)
2005
24
Partial response to treatment with recombinant interferon-alpha2a in an adult patient with tufted angioma. (14678556)
2004
25
Familial predisposition to tufted angioma: identification of blood and lymphatic vascular components. (12752572)
2003
26
Retroperitoneal kaposiform hemangioendothelioma with tufted angioma-like features in an infant with Kasabach-Merritt syndrome. (14507321)
2003
27
Response of childhood tufted angioma to the pulsed-dye laser. (12271313)
2002
28
Tufted angioma on the palm. (11737701)
2001
29
The relationship between angioblastoma (Nakagawa) and tufted angioma: report of four cases with angioblastoma and a literature-based comparison of the two conditions. (10989580)
2000
30
Tufted angioma of adult onset, revealing abundant eccrine glands and central regression. (10971067)
2000
31
Spontaneous regression of a tufted angioma. (11167986)
2000
32
Intravenous tufted angioma. (10843417)
2000
33
Acquired tufted angioma: a unique vascular lesion not previously reported in the oral mucosa. (10792235)
2000
34
Acquired tufted angioma of the lower lip mucosa. (10859727)
2000
35
Kasabach-Merritt syndrome: identification of platelet trapping in a tufted angioma by immunohistochemistry technique using monoclonal antibody to CD61. (10571842)
1999
36
Interferon for tufted angioma. (10515775)
1999
37
Acquired tufted angioma in association with a complex cutaneous vascular malformation. (10722273)
1999
38
Vascular tumors arising in port-wine stains: two cases of pyogenic granuloma and a case of acquired tufted angioma. (10659503)
1999
39
Tufted angioma, a particular form of angioma. (9252776)
1997
40
Tufted angioma: is it the same as angioblastoma (Nakagawa)? (9197842)
1997
41
Metastatic tufted angioma. (9259505)
1997
42
Tufted angioma associated with platelet trapping syndrome: response to aspirin. (9301583)
1997
43
A case of deep tufted angioma. (8632093)
1996
44
Acquired tufted angioma frequently develops at sites other than the neck and upper trunk. (8689780)
1996
45
Tufted angioma of the thigh. (8034793)
1994
46
Acquired tufted angioma associated with pregnancy. (1486719)
1992
47
An eruptive vascular proliferation resembling acquired tufted angioma in the recipient of a liver transplant. (1569251)
1992
48
Familial tufted angioma. (1458641)
1992
49
Tufted angioma (angioblastoma). A benign progressive angioma, not to be confused with Kaposi's sarcoma or low-grade angiosarcoma. (2644316)
1989
50
Acquired tufted angioma. (3777379)
1986

Variations for Tufted Angioma

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Expression for genes affiliated with Tufted Angioma

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Expression patterns in normal tissues for genes affiliated with Tufted Angioma

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Pathways for genes affiliated with Tufted Angioma

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Compounds for genes affiliated with Tufted Angioma

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Sources:
50PharmGKB, 11DrugBank, 44Novoseek, 24HMDB
See all sources

Compounds related to Tufted Angioma according to GeneCards/GeneDecks:

(show all 11)
idCompoundScoreTop Affiliating Genes
1regorafenib50 1110.4FLT4, TEK
2agar449.3ENG, IFNA2
3p002449.1TEK, ENG
4infliximab44 50 1111.1IFNA2, TEK
5matrigel448.9ENG, FLT4, TEK
6paraffin448.8TEK, FLT4, ENG
7estrogen448.8ENG, IFNA2, FLT4
8oxygen44 249.3TEK, FLT4, IFNA2, ENG
9cysteine448.2ENG, IFNA2, TEK
10tyrosine448.2ENG, IFNA2, FLT4, TEK
11vegf447.8ENG, IFNA2, PROX1, FLT4, TEK

GO Terms for genes affiliated with Tufted Angioma

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Biological processes related to Tufted Angioma according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1lymphangiogenesisGO:0019469.6FLT4, PROX1
2venous blood vessel morphogenesisGO:0488459.6ENG, PROX1
3sprouting angiogenesisGO:0020409.3FLT4, TEK
4transmembrane receptor protein tyrosine kinase signaling pathwayGO:0071699.3FLT4, TEK
5peptidyl-tyrosine phosphorylationGO:0181089.2TEK, FLT4
6protein autophosphorylationGO:0467779.2FLT4, TEK
7positive regulation of ERK1 and ERK2 cascadeGO:0703749.1FLT4, TEK
8positive regulation of endothelial cell migrationGO:0105958.9PROX1, FLT4, TEK
9positive regulation of endothelial cell proliferationGO:0019388.9PROX1, FLT4, TEK
10positive regulation of protein phosphorylationGO:0019348.9TEK, FLT4, ENG
11response to hypoxiaGO:0016668.8ENG, TEK

Molecular functions related to Tufted Angioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor bindingGO:0198389.1FLT4, TEK
2transmembrane receptor protein tyrosine kinase activityGO:0047148.9FLT4, TEK
3protein bindingGO:0055157.5ENG, IFNA2, PROX1, FLT4, TEK

Products for genes affiliated with Tufted Angioma

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Sources for Tufted Angioma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet