MCID: TFT001
MIFTS: 34

Tufted Angioma malady

Cardiovascular diseases, Fetal diseases categories

Summaries for Tufted Angioma

About this section
Sources:
63Wikipedia, 46OMIM, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:63 A tufted angioma (also known as an \"Acquired tufted angioma,\" \"Angioblastoma,\" \"Angioblastoma of... more...

MalaCards: Tufted Angioma, also known as nakagawa angioblastoma, is related to kaposi's sarcoma and sarcoma. An important gene associated with Tufted Angioma is FLT4 (fms-related tyrosine kinase 4), and among its related pathways are Tyrosine Kinases / Adaptors and Akt Signaling Pathway . The compounds Regorafenib and p002 have been mentioned in the context of this disorder. Related mouse phenotype cardiovascular system.

Description from OMIM:46 607859

Aliases & Classifications for Tufted Angioma

About this section
Sources:
42NIH Rare Diseases, 48Orphanet, 46OMIM, 60UMLS, 44Novoseek, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Fetal diseases
Anatomical: Cardiovascular diseases


Characteristics (Orphanet epidemiological data):

48
tufted angioma:
Inheritance: Sporadic; Age of onset: Childhood; Age of death: Normal


Aliases & Descriptions:

tufted angioma 42 48 46 60
nakagawa angioblastoma 48
angioma, tufted 44
angioma tufted 42


External Ids:

OMIM46 607859
MESH via Orphanet35 C536924
ICD10 via Orphanet26 D18.0
SNOMED-CT via Orphanet57 254786000
UMLS via Orphanet61 C0346073

Related Diseases for Tufted Angioma

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Tufted Angioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 51)
idRelated DiseaseScoreTop Affiliating Genes
1kaposi's sarcoma30.4TEK, FLT4, IFNA2
2sarcoma30.4TEK, ENG, FLT4
3hemangioma30.4TEK, FLT4, PROX1, IFNA2
4angiosarcoma30.2FLT4, TEK
5deep angioma10.3
6neurofibromatosis10.2
7acquired hemangioma10.2
8myofascial pain syndrome10.2
9herpes zoster10.2
10capillary hemangioma10.2
11cavernous hemangioma10.2
12hemangioma thrombocytopenia syndrome10.2
13lymphangiosarcoma10.0PROX1
14pancreatic cancer10.0FLT4
15klippel-trenaunay syndrome10.0FLT4
16cervical cancer10.0FLT4
17acute leukemia10.0FLT4
18diabetic retinopathy10.0TEK
19thyroid cancer10.0TEK
20myelofibrosis10.0IFNA2
21arthritis10.0TEK
22lymphangioma10.0PROX1, FLT4
23hemangioendothelioma10.0FLT4, IFNA2
24epithelioid hemangioendothelioma10.0IFNA2, FLT4
25papilloma10.0IFNA2, FLT4
26lymphedema10.0FLT4, PROX1
27colon cancer10.0FLT4, ENG
28vascular cancer10.0ENG, FLT4
29myeloproliferative disorder10.0ENG, IFNA2
30inflammatory breast carcinoma10.0PROX1, TEK
31pyogenic granuloma10.0TEK, FLT4
32vascular disease10.0FLT4, TEK
33intracranial hemorrhage in brain cerebrovascular malformations10.0TEK, ENG
34hepatitis c10.0ENG, IFNA2
35psoriasis10.0TEK, ENG
36proteinuria10.0TEK, ENG
37ischemia10.0TEK, ENG
38rheumatoid arthritis10.0TEK, ENG
39endometriosis10.0TEK, ENG
40papillary thyroid carcinoma10.0ENG, TEK
41colorectal cancer10.0ENG, FLT4, IFNA2
42non-small cell lung carcinoma10.0FLT4, TEK
43hepatocellular carcinoma10.0ENG, IFNA2, TEK
44endometrial carcinoma10.0ENG, TEK, FLT4
45breast cancer10.0FLT4, TEK, ENG
46malignant glioma10.0FLT4, ENG, TEK
47stomach cancer10.0ENG, FLT4, TEK
48kidney cancer10.0ENG, TEK, FLT4, IFNA2
49squamous cell carcinoma10.0ENG, TEK, FLT4
50melanoma10.0ENG, FLT4, TEK, IFNA2

Graphical network of the top 20 diseases related to Tufted Angioma:



Diseases related to tufted angioma

Clinical Features for Tufted Angioma

About this section
Sources:
46OMIM
See all sources

Clinical features from OMIM:

607859

Clinical synopsis from OMIM:

607859

Drugs & Therapeutics for Tufted Angioma

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Tufted Angioma

Drug clinical trials:

Search ClinicalTrials for Tufted Angioma

Search NIH Clinical Center for Tufted Angioma

Search CenterWatch for Tufted Angioma

Genetic Tests for Tufted Angioma

About this section

Anatomical Context for Tufted Angioma

About this section

Animal Models for Tufted Angioma or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Tufted Angioma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.4ENG, TEK, PROX1, FLT4

Publications for Tufted Angioma

About this section

Genetic Variations for Tufted Angioma

About this section

Expression for genes affiliated with Tufted Angioma

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Tufted Angioma

Search GEO for disease gene expression data for Tufted Angioma.

Pathways for genes affiliated with Tufted Angioma

About this section
Sources:
4Cell Signaling Technology, 52R&D Systems, 51QIAGEN, 29KEGG
See all sources

Pathways related to Tufted Angioma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4TEK, FLT4
29.4TEK, FLT4
38.9ENG, TEK, FLT4
4
Hide members
8.6IFNA2, FLT4, TEK
58.6TEK, FLT4, IFNA2
6
Hide members
8.6TEK, FLT4, IFNA2

Compounds for genes affiliated with Tufted Angioma

About this section
Sources:
11DrugBank, 44Novoseek, 49PharmGKB, 24HMDB
See all sources

Compounds related to Tufted Angioma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1Regorafenib119.5FLT4, TEK
2p002449.3ENG, TEK
3matrigel449.0ENG, TEK, FLT4
4infliximab44 49 1110.9TEK, IFNA2
5paraffin448.9ENG, TEK, FLT4
6oxygen44 249.2IFNA2, FLT4, TEK, ENG
7tyrosine447.8IFNA2, FLT4, TEK, ENG
8vegf447.7ENG, TEK, PROX1, FLT4, IFNA2

GO Terms for genes affiliated with Tufted Angioma

About this section
Sources:
16Gene Ontology
See all sources

Biological processes related to Tufted Angioma according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of protein phosphorylationGO:00193410.2FLT4
2lymphangiogenesisGO:0019469.6FLT4, PROX1
3venous blood vessel morphogenesisGO:0488459.5ENG, PROX1
4sprouting angiogenesisGO:0020409.4TEK, FLT4
5positive regulation of ERK1 and ERK2 cascadeGO:0703749.4TEK, FLT4
6peptidyl-tyrosine phosphorylationGO:0181089.3TEK, FLT4
7transmembrane receptor protein tyrosine kinase signaling pathwayGO:0071699.1TEK, FLT4
8positive regulation of endothelial cell migrationGO:0105959.1TEK, PROX1, FLT4
9positive regulation of endothelial cell proliferationGO:0019389.1FLT4, PROX1, TEK

Molecular functions related to Tufted Angioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transmembrane receptor protein tyrosine kinase activityGO:0047149.4TEK, FLT4

Products for genes affiliated with Tufted Angioma

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Tufted Angioma

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet