MCID: TLR001
MIFTS: 40

Tularemia malady

Infectious category

Summaries for Tularemia

Sources:
8Disease Ontology, 43NIH Rare Diseases, 3CDC, 64Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
NIH Rare Diseases:43 Tularemia is an infection common in wild rodents caused by the bacterium francisella tularensis. it is transmitted to humans by contact with infected animal tissues or by ticks, biting flies, and mosquitoes. the condition is most common in north america and parts of europe and asia. it is very rare in the united states. the illness, which is characterized by fever, chills, headache, joint pain and muscle weakness, may continue for several weeks after symptoms begin. streptomycin and tetracycline are commonly used to treat the infection. last updated: 5/10/2010

MalaCards: Tularemia, also known as francisella tularensis infection, is related to pneumonic tularemia and oculoglandular tularemia. An important gene associated with Tularemia is MYD88 (myeloid differentiation primary response 88), and among its related pathways are NTHi-Induced Signaling and Leishmaniasis. The compound flagellin have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and brain, and related mouse phenotype tumorigenesis.

Disease Ontology:8 A primary bacterial infectious disease that has material basis in francisella tularensis, which is transmitted by dog tick bite (dermacentor variabilis), transmitted by deer flies (chrysops sp) or transmitted by contact with infected animal tissues.

CDC:3 Tularemia is a disease of animals and humans caused by the bacterium Francisella tularensis. Rabbits, hares, and rodents are especially susceptible and often die in large numbers during outbreaks. Humans can become infected through several routes, including:

Wikipedia:64 Tularemia (or tularaemia; also known as Pahvant Valley plague,rabbit fever,deer fly fever, and Ohara\'s... more...

Aliases & Classifications for Tularemia

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 49Orphanet, 61UMLS, 57SNOMED-CT, 27ICD9CM, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious


Aliases & Descriptions:

tularemia 8 43 10 49 61
francisella tularensis infection 43
pahvant valley plague 43
deerfly fever 43
ohara disease 43
lemming fever 43


External Ids:

Disease Ontology8 DOID:2123
ICD9CM27 021.8
MESH via Orphanet36 D014406
ICD10 via Orphanet26 A21
SNOMED-CT via Orphanet58 19265001
UMLS via Orphanet62 C0041351

Related Diseases for Tularemia

Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Tularemia:



Diseases related to tularemia

Clinical Features for Tularemia

Drugs & Therapeutics for Tularemia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Tularemia

Drug clinical trials:

Search ClinicalTrials for Tularemia

Search NIH Clinical Center for Tularemia

Search CenterWatch for Tularemia

Genetic Tests for Tularemia

Anatomical Context for Tularemia

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Tularemia:

33
Skin, Liver, Brain, Kidney, Lymph node, Spleen, Whole blood, Myeloid, T cells, B cells

Animal Models for Tularemia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Tularemia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.6IL2, MYD88, STAB2, PSME2, TLR2

Publications for Tularemia

Sources:
51PubMed
See all sources

Articles related to Tularemia:

(show top 50)    (show all 506)
idTitleAuthorsYear
1
A case of tularemia after an endurance run in a non-endemic region. (23074014)
2013
2
Letter regarding "Characteristics and management of intractable neck involvement in tularemia". (22872062)
2013
3
Tularemia in central Anatolia. (23104256)
2013
4
Assessment of antimicrobial peptide LL-37 as a post-exposure therapy to protect against respiratory tularemia in mice. (23500517)
2013
5
Clinical and laboratory findings of tularemia: a retrospective analysis. (22339565)
2012
6
Generation of a convalescent model of virulent Francisella tularensis infection for assessment of host requirements for survival of tularemia. (22428026)
2012
7
Outbreaks of tularemia in a boreal forest region depends on mosquito prevalence. (22124130)
2012
8
Other tick-borne illnesses: tularemia, Colorado tick fever, tick paralysis. (22608124)
2012
9
Modeling inhalational tularemia: deliberate release and public health response. (22044315)
2011
10
Long lived protection against pneumonic tularemia is correlated with cellular immunity in peripheral, not pulmonary, organs. (20688042)
2010
11
Tularemia. (19713053)
2010
12
A neglected cause of cervical lymphadenitis. Oropharyngeal tularemia. (18626545)
2008
13
Ulceroglandular tularemia in a nonendemic area. (17396737)
2007
14
Epizootic of tularemia in an outdoor housed group of cynomolgus monkeys (Macaca fascicularis). (17491074)
2007
15
Prevalence of infection with Francisella tularensis, Borrelia burgdorferi sensu lato and Anaplasma phagocytophilum in rodents from an endemic focus of tularemia in Bulgaria. (16028881)
2005
16
A novel screening ELISA and a confirmatory Western blot useful for diagnosis and epidemiological studies of tularemia. (16050523)
2005
17
First reported prairie dog-to-human tularemia transmission, Texas, 2002. (15109417)
2004
18
Pulmonary manifestations of other agents: brucella, Q fever, tularemia and smallpox. (15062230)
2004
19
Missed sentinel case of naturally occurring pneumonic tularemia outbreak: lessons for detection of bioterrorism. (12949036)
2003
20
Reconstruction and prognosis of water vole population dynamics on the basis of tularemia morbidity among Novosibirsk oblast residents. (12705132)
2003
21
An outbreak of primary pneumonic tularemia. (11924660)
2002
22
Tularemia: a practical guide to management in the event of a tick bite or terrorist attack. (12394080)
2002
23
An outbreak of primary pneumonic tularemia. (11919317)
2002
24
Tularemia, Kosovo. (10821074)
2000
25
Acute glaucoma and acute corneal oedema in association with tularemia. (9527343)
1997
26
Epidemiological analysis of tularemia in Japan (yato-byo). (8861026)
1996
27
Typhoidal tularemia in a human immunodeficiency virus-infected adolescent. (8878235)
1996
28
Cytokine expression in the liver during the early phase of murine tularemia. (7822019)
1995
29
Tularemia fatality. (7477450)
1995
30
Skin manifestations of tularemia. (7928027)
1994
31
Tularemia presenting as an isolated pleural effusion. (1574890)
1992
32
Macrophage activating factors produced in the course of murine tularemia: effect on multiplication of microbes. (1300982)
1992
33
Acute tularemia in three domestic cats. (1778744)
1991
34
Plague and tularemia. (2051013)
1991
35
The production of oxygen metabolites and their possible regulatory role in the course of tularemia infection. (1702745)
1990
36
Leads from the MMWR. Tularemia--New Jersey. (3795412)
1987
37
Tick-borne tularemia. An outbreak of lymphadenopathy in children. (4057512)
1985
38
A tale of tularemia. (6701107)
1984
39
Clinically mild tularemia associated with tick-borne Francisella tularensis. (6886487)
1983
40
Tularemia pneumonia mimicking legionnaires' disease: isolation of organism on CYE agar and successful treatment with erythromycin. (6612398)
1983
41
Oropharyngeal tularemia: an uncommon cause of pharyngitis, fever, and adenopathy. (7252456)
1981
42
Enzyme-linked immunosorbent assay for immunological diagnosis of human tularemia. (120873)
1979
43
Cavitary pneumonia associated with tularemia. (630947)
1978
44
Tularemia in a mule deer. (16498895)
1976
45
Chronic shedding tularemia nephritis in rodents: possible relation to occurrence of Francisella tularensis in lotic waters. (239255)
1975
46
Tularemia in an inner city child. (4821824)
1974
47
Bubonic plague misdiagnosed as tularemia. Retrospective serologic diagnosis. (4678367)
1972
48
Oculoglandular tularemia: a case report. (5411798)
1970
49
OCULOGLANDULAR TULAREMIA: TRANSMISSION FROM RABBIT, THROUGH DOG AND TICK TO MAN. (14320040)
1965
50
GUILLAIN-BARRE SYNDROME ASSOCIATED WITH ULCEROGLANDULAR TULAREMIA. (14215606)
1964

Genetic Variations for Tularemia

Expression for genes affiliated with Tularemia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Tularemia

Search GEO for disease gene expression data for Tularemia.

Pathways for genes affiliated with Tularemia

Sources:
52QIAGEN, 30KEGG
See all sources

Pathways related to Tularemia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0MYD88, TLR2
2
Hide members
9.7IL2, MYD88, TLR2

Compounds for genes affiliated with Tularemia

Sources:
45Novoseek, 29IUPHAR
See all sources

Compounds related to Tularemia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1flagellin45 2911.0MYD88, TLR2

GO Terms for genes affiliated with Tularemia

Sources:
16Gene Ontology
See all sources

Biological processes related to Tularemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of interleukin-17 productionGO:03274010.0IL2, MYD88

Products for genes affiliated with Tularemia

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Tularemia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet