MCID: TLR001
MIFTS: 53

Tularemia malady

Rare diseases, Infectious diseases categories
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Summaries for Tularemia

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8Disease Ontology, 43NIH Rare Diseases, 4CDC, 65Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Tularemia is an infection common in wild rodents caused by the bacterium francisella tularensis. it is transmitted to humans by contact with infected animal tissues or by ticks, biting flies, and mosquitoes. the condition is most common in north america and parts of europe and asia. it is very rare in the united states. the illness, which is characterized by fever, chills, headache, joint pain and muscle weakness, may continue for several weeks after symptoms begin. streptomycin and tetracycline are commonly used to treat the infection. last updated: 5/10/2010

MalaCards: Tularemia, also known as francisella tularensis infection, is related to pneumonia and lyme disease. An important gene associated with Tularemia is PPARA (peroxisome proliferator-activated receptor alpha), and among its related pathways are Th1 Differentiation and MAPK Pathway. The compounds docosahexaenoic acid and isotretinoin have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and t cells, and related mouse phenotypes are tumorigenesis and liver/biliary system.

Disease Ontology:8 A primary bacterial infectious disease that has material basis in francisella tularensis, which is transmitted by dog tick bite (dermacentor variabilis), transmitted by deer flies (chrysops sp) or transmitted by contact with infected animal tissues.

CDC:4 Tularemia is a disease of animals and humans caused by the bacterium Francisella tularensis. Rabbits, hares, and rodents are especially susceptible and often die in large numbers during outbreaks. Humans can become infected through several routes, including:

Wikipedia:65 Tularemia (or tularaemia; also known as Pahvant Valley plague,rabbit fever,deer fly fever, and Ohara\'s... more...

Aliases & Classifications for Tularemia

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8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 49Orphanet, 62UMLS, 58SNOMED-CT, 27ICD9CM, 36MESH via Orphanet, 59SNOMED-CT via Orphanet, 26ICD10 via Orphanet, 63UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Infectious diseases


Aliases & Descriptions:

tularemia 8 43 10 49 62
francisella tularensis infection 43
pahvant valley plague 43
deerfly fever 43
ohara disease 43
lemming fever 43
rabbit fever 43
yatobyo 43


External Ids:

Disease Ontology8 DOID:2123
ICD9CM27 021.8
MESH via Orphanet36 D014406
SNOMED-CT via Orphanet59 19265001
ICD10 via Orphanet26 A21.0, A21.1, A21.2 A21.3, A21.7, A21.8, A21.9, more
UMLS via Orphanet63 C0041351

Related Diseases for Tularemia

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Tularemia:



Diseases related to tularemia

Symptoms for Tularemia

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Drugs & Therapeutics for Tularemia

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

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Genetic Tests for Tularemia

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Anatomical Context for Tularemia

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33MalaCards
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MalaCards organs/tissues related to Tularemia:

33
Skin, Testes, T cells, Whole blood, Lymph node, Kidney, Liver, Spleen, Brain, Myeloid, B cells

Animal Models for Tularemia or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Tularemia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.0IL2, STAB2, TLR2
2MP:00053708.5IL2, STAB2, TLR2, PPARA
3MP:00053858.3PPARA, TLR2, STAB2, IL2

Publications for Tularemia

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52PubMed
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Articles related to Tularemia:

(show top 50)    (show all 496)
idTitleAuthorsYear
1
Tuberculosis or tularemia? A molecular study in cervical lymphadenitis. (24239221)
2014
2
Tularemia: a re-emerging condition in Turkey which may be related with contaminated spring water in rural areas. (24190761)
2014
3
Tularemia during pregnancy: report of four cases. (22998506)
2013
4
Granulomatous lymphadenitis can also be seen in tularemia, not only in tuberculosis. (23219034)
2013
5
Unilateral acute dacryocystitis associated with oculoglandular tularemia: a case report. (23448564)
2013
6
Guillain-BarrAc syndrome and ulceroglandular tularemia. (23896779)
2013
7
Post-exposure immunization against Francisella tularensis membrane proteins augments protective efficacy of gentamicin in a mouse model of pneumonic tularemia. (22652404)
2012
8
Tularemia progression accompanied with oxidative stress and antioxidant alteration in spleen and liver of BALB/c mice. (22752903)
2012
9
Two cases of glandular tularemia from Turkey. (22734313)
2012
10
Pneumonic tularemia in rabbits resembles the human disease as illustrated by radiographic and hematological changes after infection. (21931798)
2011
11
Oropharyngeal tularemia mimicking tumoral relapse in a patient with Hodgkin lymphoma in remission. (21853659)
2011
12
Development of tolerogenic dendritic cells and regulatory T cells favors exponential bacterial growth and survival during early respiratory tularemia. (21724804)
2011
13
Real-time PCR for diagnosis of oculoglandular tularemia. (20031067)
2010
14
Glycogen synthase kinase-3beta (GSK3beta) inhibition suppresses the inflammatory response to Francisella infection and protects against tularemia in mice. (18929413)
2009
15
Water-borne outbreak of oropharyngeal and glandular tularemia in Georgia: investigation and follow-up. (19826763)
2009
16
Tularemia, plague, yersiniosis, and Tyzzer's disease in wild rodents and lagomorphs in Canada: a review. (20190973)
2009
17
Landscape epidemiology of tularemia outbreaks in Sweden. (19961673)
2009
18
Assessment of low-molecular-weight antioxidants in Francisella tularensis infected hosts: comparison of two rodents with different susceptibility to tularemia. (20027169)
2009
19
Tularemia in range sheep: an overlooked syndrome? (18599860)
2008
20
Re-emergence of tularemia in Germany: presence of Francisella tularensis in different rodent species in endemic areas. (19014635)
2008
21
Generation and characterization of hybridoma antibodies for immunotherapy of tularemia. (17764754)
2007
22
Diagnosis of tularemia using piezoelectric biosensor technology. (19071403)
2007
23
Comparison of the 2000 and 2005 outbreaks of tularemia in the Duzce region of Turkey. (17314427)
2007
24
Pneumonic tularemia on Martha's Vineyard: clinical, epidemiologic, and ecological characteristics. (17442781)
2007
25
Tularemia after a dormouse bite in Switzerland. (15856137)
2005
26
First reported prairie dog-to-human tularemia transmission, Texas, 2002. (15109417)
2004
27
Anthrax, botulism and tularemia in Italy. (12749299)
2003
28
A procedure for differentiating between the intentional release of biological warfare agents and natural outbreaks of disease: its use in analyzing the tularemia outbreak in Kosovo in 1999 and 2000. (12197873)
2002
29
Ciprofloxacin for treatment of tularemia in children. (10819342)
2000
30
The influence of immunization with tularemia live vaccine on the clastogenic action of cyclophosphamide in mice. (8841489)
1996
31
Field investigations of tularemia in Norway. (8861027)
1996
32
Relapse of tularemia after aminoglycoside therapy: case report and discussion of therapeutic options. (7727647)
1995
33
Live tularemia vaccine but not proteins purified from Francisella tularensis can confer protection against lethal Listeria infection in mice. (7748535)
1995
34
Tularemia: a differential diagnosis in oto-rhino-laryngology. (8496644)
1993
35
Tularemia pneumonia in Oklahoma, 1982-1987. (1593309)
1992
36
Francisella tularensis-induced in vitro gamma interferon, tumor necrosis factor alpha, and interleukin 2 responses appear within 2 weeks of tularemia vaccination in human beings. (1909711)
1991
37
Influence of genetic background on host resistance to experimental murine tularemia. (3397185)
1988
38
Bronchial changes in airborne tularemia. (3772243)
1986
39
Tick-borne tularemia. An outbreak of lymphadenopathy in children. (4057512)
1985
40
A family outbreak of tularemia. (3842118)
1985
41
Oropharyngeal tularemia. (6572814)
1983
42
Hepatic porphyrias simulating typhoidal tularemia. (7090965)
1982
43
Tularemia: review of eight cases of tick-borne infection and the epidemiology of the disease in Georgia. (7071635)
1982
44
Tick-borne tularemia presenting as ulcerative lymphadenitis. (428180)
1979
45
Enzyme-linked immunosorbent assay for immunological diagnosis of human tularemia. (120873)
1979
46
Cavitary pneumonia associated with tularemia. (630947)
1978
47
One-half century of tularemia in Florida. (1099166)
1975
48
Chronic shedding tularemia nephritis in rodents: possible relation to occurrence of Francisella tularensis in lotic waters. (239255)
1975
49
Bubonic plague misdiagnosed as tularemia. Retrospective serologic diagnosis. (4678367)
1972
50
OCULOGLANDULAR TULAREMIA: TRANSMISSION FROM RABBIT, THROUGH DOG AND TICK TO MAN. (14320040)
1965

Variations for Tularemia

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Expression for genes affiliated with Tularemia

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Tularemia

Search GEO for disease gene expression data for Tularemia.

Pathways for genes affiliated with Tularemia

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50PathCards, 54R&D Systems, 38NCBI BioSystems Database, 61Tocris Bioscience, 30KEGG, 53QIAGEN
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Compounds for genes affiliated with Tularemia

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45Novoseek, 29IUPHAR, 24HMDB, 11DrugBank, 51PharmGKB, 61Tocris Bioscience
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Compounds related to Tularemia according to GeneCards/GeneDecks:

(show all 19)
idCompoundScoreTop Affiliating Genes
1docosahexaenoic acid45 29 2411.9PPARA, TLR2
2isotretinoin45 1110.8IL2, PPARA
3polyinosinic-polycytidylic acid459.8IL2, TLR2
4oleic acid45 29 24 1112.8TLR2, PPARA
5il 10459.7IL2, TLR2
6stearic acid45 24 1111.7PPARA, IL2
7palmitate459.6TLR2, PPARA
8ionomycin459.5IL2, TLR2
9tacrolimus45 51 1111.4IL2, TLR2, PPARA
10calcitriol45 61 24 1112.4IL2, TLR2, PPARA
11actinomycin d459.4IL2, TLR2, PPARA
12pge2459.3PPARA, TLR2, IL2
13simvastatin45 51 61 29 24 1114.3TLR2, PPARA
14gf 109203x45 6110.3PPP1R14A, TLR2
15cycloheximide459.3IL2, TLR2, PPARA
16dexamethasone45 51 29 1112.2PPARA, TLR2, IL2
17histamine45 29 2411.2PPP1R14A, TLR2, IL2
18vegf459.2IL2, TLR2, PPARA
19serine458.7PPARA, PPP1R14A, TLR2, IL2

GO Terms for genes affiliated with Tularemia

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16Gene Ontology
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Cellular components related to Tularemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.5STAB2, TLR2

Biological processes related to Tularemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to hypoxiaGO:0016669.6TLR2, PPARA
2response to insulinGO:0328689.5TLR2, PPARA
3positive regulation of inflammatory responseGO:0507299.5IL2, TLR2
4positive regulation of transcription from RNA polymerase II promoterGO:0459448.8IL2, TLR2, PPARA

Products for genes affiliated with Tularemia

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Sources for Tularemia

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet