MCID: TLR001
MIFTS: 44

Tularemia malady

Infectious diseases category

Summaries for Tularemia

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8Disease Ontology, 42NIH Rare Diseases, 3CDC, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Tularemia is an infection common in wild rodents caused by the bacterium francisella tularensis. it is transmitted to humans by contact with infected animal tissues or by ticks, biting flies, and mosquitoes. the condition is most common in north america and parts of europe and asia. it is very rare in the united states. the illness, which is characterized by fever, chills, headache, joint pain and muscle weakness, may continue for several weeks after symptoms begin. streptomycin and tetracycline are commonly used to treat the infection. last updated: 5/10/2010

MalaCards: Tularemia, also known as francisella tularensis infection, is related to pneumonia and influenza. An important gene associated with Tularemia is MYD88 (myeloid differentiation primary response 88), and among its related pathways are NTHi-Induced Signaling and Leishmaniasis. The compound flagellin have been mentioned in the context of this disorder. Affiliated tissues include testes, skin and t cells, and related mouse phenotype tumorigenesis.

Disease Ontology:8 A primary bacterial infectious disease that has material basis in francisella tularensis, which is transmitted by dog tick bite (dermacentor variabilis), transmitted by deer flies (chrysops sp) or transmitted by contact with infected animal tissues.

CDC:3 Tularemia is a disease of animals and humans caused by the bacterium Francisella tularensis. Rabbits, hares, and rodents are especially susceptible and often die in large numbers during outbreaks. Humans can become infected through several routes, including:

Wikipedia:63 Tularemia (or tularaemia; also known as Pahvant Valley plague,rabbit fever,deer fly fever, and Ohara\'s... more...

Aliases & Classifications for Tularemia

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 48Orphanet, 60UMLS, 56SNOMED-CT, 27ICD9CM, 35MESH via Orphanet, 57SNOMED-CT via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Aliases & Descriptions:

tularemia 8 42 10 48 60
francisella tularensis infection 42
pahvant valley plague 42
deerfly fever 42
ohara disease 42
lemming fever 42


External Ids:

Disease Ontology8 DOID:2123
ICD9CM27 021.8
MESH via Orphanet35 D014406
SNOMED-CT via Orphanet57 19265001
ICD10 via Orphanet26 A21.0, A21.1, A21.2 A21.3, A21.7, A21.8, A21.9, more
UMLS via Orphanet61 C0041351

Related Diseases for Tularemia

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Tularemia:



Diseases related to tularemia

Clinical Features for Tularemia

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Drugs & Therapeutics for Tularemia

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Tularemia

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Anatomical Context for Tularemia

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32MalaCards
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MalaCards organs/tissues related to Tularemia:

32
Testes, Skin, T cells, Whole blood, Lymph node, Kidney, Liver, Spleen, Brain, Myeloid, B cells

Animal Models for Tularemia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Tularemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.6IL2, MYD88, STAB2, PSME2, TLR2

Publications for Tularemia

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50PubMed
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Articles related to Tularemia:

(show top 50)    (show all 505)
idTitleAuthorsYear
1
Tularemia in differential diagnosis of cervical lymphadenopathy: cytologic features of tularemia lymphadenitis. (24192314)
2014
2
Tularemia during pregnancy: report of four cases. (22998506)
2013
3
Correction: Yopp-Expressing Variant ofY. pestis Activates a Potent Innate Immune Response Affording Cross-Protection against Yersiniosis and Tularemia. (24376484)
2013
4
Tularemia outbreaks in Kayseri, Turkey: An evaluation of the effect of climate change and climate variability on tularemia outbreaks. (24216516)
2013
5
Tularemia endocarditis from domestic pet exposure. (23910519)
2013
6
Separating the chaff from the grain (Tularemia). (22696886)
2012
7
Oropharyngeal tularemia mimicking tumoral relapse in a patient with Hodgkin lymphoma in remission. (21853659)
2011
8
Histologic, immunohistochemical, microbiological, molecular biological and ultrastructural characterization of pulmonary tularemia. (20709464)
2011
9
Oropharyngeal tularemia in father and son after consumption of under-cooked rabbit meat. (21736510)
2011
10
Ulceroglandular tularemia. (21501382)
2011
11
Immunoproteomic analysis of the human antibody response to natural tularemia infection with Type A or Type B strains or LVS vaccination. (21873113)
2011
12
Ulceroglandular tularemia. (20678093)
2011
13
Real-time PCR for diagnosis of oculoglandular tularemia. (20031067)
2010
14
Tularemia in bulgaria 2003-2004. (21252445)
2010
15
Tularemia is becoming increasingly important as a differential diagnosis in suspicious neck masses: experience in Turkey. (19084982)
2009
16
A tularemia outbreak in an extended family in Tokat Province, Turkey: observing the attack rate of tularemia. (19195917)
2009
17
Administration of a synthetic TLR4 agonist protects mice from pneumonic tularemia. (18490759)
2008
18
Generation and characterization of hybridoma antibodies for immunotherapy of tularemia. (17764754)
2007
19
Diversity of Francisella tularensis Schu4 antigens recognized by T lymphocytes after natural infections in humans: identification of candidate epitopes for inclusion in a rationally designed tularemia vaccine. (17291638)
2007
20
New approaches to diagnosis and therapy of tularemia. (17468229)
2007
21
Inactivated Francisella tularensis live vaccine strain protects against respiratory tularemia by intranasal vaccination in an immunoglobulin A-dependent fashion. (17296747)
2007
22
Epidemiologic characteristics of tularemia in Slovakia. (16913089)
2006
23
Tularemia induced bilateral optic neuritis. (16562762)
2006
24
Proteomic analysis of anti-Francisella tularensis LVS antibody response in murine model of tularemia. (15892173)
2005
25
Anthrax, botulism and tularemia in Italy. (12749299)
2003
26
Experimental tularemia in mice challenged by aerosol or intradermally with virulent strains of Francisella tularensis: bacteriologic and histopathologic studies. (12732472)
2003
27
Tularemia: lymphadenitis with a twist. (11905292)
2002
28
Tularemia revisited. (11757513)
2001
29
Importance of surveillance of tularemia natural foci in the known endemic area of Central Europe, 1991-1997. (11467089)
2001
30
Ciprofloxacin for treatment of tularemia in children. (10819342)
2000
31
Cat-bite tularemia in a seventeen-year-old girl treated with ciprofloxacin. (10877184)
2000
32
Pneumonic tularemia in a patient with chronic granulomatous disease. (9314451)
1997
33
Development of Francisella tularensis antigen responses measured as T-lymphocyte proliferation and cytokine production (tumor necrosis factor alpha, gamma interferon, and interleukin-2 and -4) during human tularemia. (1674737)
1991
34
Lawnmower tularemia. (2336320)
1990
35
Pleuropulmonary tularemia: successful treatment with erythromycin. (2237578)
1990
36
Agglutinins and antibodies to Francisella tularensis outer membrane antigens in the early diagnosis of disease during an outbreak of tularemia. (3356786)
1988
37
Typhoidal tularemia presenting as enteritis with leukopenia. (3176624)
1988
38
Detection of antigen in urine of a patient with tularemia. (3622500)
1987
39
Tularemia in otolaryngologic practice. An analysis of 127 cases. (2866760)
1986
40
A whole-blood lymphocyte stimulation test for the diagnosis of human tularemia. (6501932)
1984
41
Sequential metabolic alterations in the myocardium during influenza and tularemia in mice. (6746101)
1984
42
An endemic case of tularemia in the mountain hare (Lepus timidus) on the island of Stora KarlsAP. (6393050)
1984
43
Tularemia: atypical presentation. (6738121)
1984
44
Hepatic abscess complicating ulceroglandular tularemia. (6652596)
1983
45
Tularemia associated with domestic cats--Georgia, New Mexico. (6799767)
1982
46
Fatal-cat trasmitted tularemia: demonstration of the organism in tissue. (6153473)
1980
47
Modulation of delayed-type hypersensitivity and cellular immunity to microbial vaccines: effects of cyclophosphamide on the immune response to tularemia vaccine. (924675)
1977
48
TYPHOIDAL TULAREMIA. (14088466)
1963
49
Ulcero-glandular tularemia. (14918814)
1952
50
Oculoglandular tularemia; report of three cases with unusual contacts. (20986521)
1946

Genetic Variations for Tularemia

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Expression for genes affiliated with Tularemia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Tularemia

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Pathways for genes affiliated with Tularemia

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51QIAGEN, 29KEGG
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Pathways related to Tularemia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0MYD88, TLR2
2
Hide members
9.7IL2, MYD88, TLR2

Compounds for genes affiliated with Tularemia

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44Novoseek, 28IUPHAR
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Compounds related to Tularemia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1flagellin44 2811.0MYD88, TLR2

GO Terms for genes affiliated with Tularemia

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16Gene Ontology
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Biological processes related to Tularemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of interleukin-17 productionGO:03274010.0IL2, MYD88

Products for genes affiliated with Tularemia

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Sources for Tularemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet