MCID: TLR001
MIFTS: 44

Tularemia

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Tularemia

MalaCards integrated aliases for Tularemia:

Name: Tularemia 12 72 49 55 3 41 14 69
Francisella Tularensis Infection 49
Pahvant Valley Plague 49
Deerfly Fever 49
Lemming Fever 49
Ohara Disease 49
Rabbit Fever 49
Yatobyo 49

Characteristics:

Orphanet epidemiological data:

55
tularemia
Prevalence: 1-9/1000000 (Europe),<1/1000000 (United Kingdom),<1/1000000 (Netherlands),1-9/100000 (Sweden),1-9/100000 (Czech Republic),1-9/100000 (Finland),1-9/1000000 (Austria),<1/1000000 (Belgium),<1/1000000 (Denmark),1-9/1000000 (Croatia),1-9/1000000 (Bulgaria),<1/1000000 (Estonia),<1/1000000 (France),<1/1000000 (Germany),<1/1000000 (Italy),1-9/1000000 (Latvia),<1/1000000 (Lithuania),<1/1000000 (Poland),<1/1000000 (Romania),<1/1000000 (Slovenia),1-9/1000000 (Switzerland),1-9/1000000 (Spain),1-9/100000 (Norway); Age of onset: All ages; Age of death: any age;

Classifications:

Orphanet: 55  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:2123
ICD9CM 34 021.8
MeSH 41 D014406
Orphanet 55 ORPHA3392
MESH via Orphanet 42 D014406
UMLS via Orphanet 70 C0041351
ICD10 via Orphanet 33 A21.0 A21.1 A21.2 more

Summaries for Tularemia

NIH Rare Diseases : 49 Tularemia is an infection caused by the bacterium Francisella tularensis. It is more common in rodents and rabbits but has been found in other animals including domestic cats, sheep, birds, and hamsters. Humans can become infected in several different ways: by handling infected animals, through tick or deer fly bites, by drinking contaminated water, or by inhaling contaminated dust or aerosols. Person-to-person transmission has not been reported. The type of tularemia and the particular signs and symptoms vary depending on how the bacteria enter the body. However, fever is seen in most cases. Though tularemia can be life-threatening, most infections can be treated with antibiotics. Last updated: 10/3/2017

MalaCards based summary : Tularemia, also known as francisella tularensis infection, is related to pneumonic tularemia and ulceroglandular tularemia. An important gene associated with Tularemia is SLC11A1 (Solute Carrier Family 11 Member 1), and among its related pathways/superpathways are Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways and Nucleotide-binding Oligomerization Domain (NOD) pathway. The drug Vaccines has been mentioned in the context of this disorder. Affiliated tissues include skin, lymph node and testes.

CDC : 3 Tularemia is a disease of animals and humans caused by the bacterium Francisella tularensis. Rabbits, hares, and rodents are especially susceptible and often die in large numbers during outbreaks. Humans can become infected through several routes, including:

Disease Ontology : 12 A primary bacterial infectious disease that has material basis in Francisella tularensis, which is transmitted_by dog tick bite (Dermacentor variabilis), transmitted_by deer flies (Chrysops sp) or transmitted_by contact with infected animal tissues.

Wikipedia : 72 Tularemia, also known as rabbit fever, is an infectious disease caused by the bacterium Francisella... more...

Related Diseases for Tularemia

Diseases related to Tularemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 79)
# Related Disease Score Top Affiliating Genes
1 pneumonic tularemia 33.6 FTL STAB2 TLR2
2 ulceroglandular tularemia 32.7 CASP1 PDE6B STAB2
3 mycobacterium tuberculosis 1 29.0 HSPE1 MBL2 P2RX7 SLC11A1 TLR2
4 oculoglandular tularemia 12.3
5 glandular tularemia 12.3
6 typhoidal tularemia 12.3
7 gastrointestinal tularemia 12.2
8 tick infestation 11.2
9 nontuberculous mycobacterial lung disease 10.3 SLC11A1 TLR2
10 prosthetic joint infection 10.2 MBL2 TLR2
11 cervicitis 10.2
12 plague 10.2
13 neisseria meningitidis infection 10.2 MBL2 TLR2
14 lymphadenitis 10.2
15 rheumatic fever 10.2 MBL2 TLR2
16 pneumonia 10.2
17 invasive aspergillosis 10.1 MBL2 TLR2
18 extrapulmonary tuberculosis 10.1 P2RX7 SLC11A1 TLR2
19 rheumatic heart disease 10.0 MBL2 TLR2
20 q fever 10.0
21 leptospirosis 10.0
22 spotted fever 10.0
23 pulmonary tuberculosis 9.9 MBL2 P2RX7 SLC11A1 TLR2
24 leprosy 3 9.9 HSPE1 SLC11A1 TLR2
25 hepatitis 9.9
26 rocky mountain spotted fever 9.9
27 brucellosis 9.9
28 pharyngitis 9.9
29 influenza 9.9
30 primary bacterial infectious disease 9.8 PDE6B SLC11A1 TLR2
31 metabolic encephalomyopathic crises, recurrent, with rhabdomyolysis, cardiac arrhythmias, and neurodegeneration 9.8
32 lymphoma 9.8
33 endocarditis 9.8
34 tick paralysis 9.8
35 listeriosis 9.8
36 smallpox 9.8
37 meningitis 9.8
38 transmitted_by 9.8
39 legionellosis 9.7 CASP1 TLR2
40 lymphoma, hodgkin, classic 9.7
41 ataxia and polyneuropathy, adult-onset 9.7
42 psoriatic arthritis 9.7
43 myocardial infarction 9.7
44 legionnaire disease 9.7
45 microcephaly, epilepsy, and diabetes syndrome 9.7
46 bacteremia 2 9.7
47 graft-versus-host disease 9.7
48 b-cell expansion with nfkb and t-cell anergy 9.7
49 acute myocardial infarction 9.7
50 adult respiratory distress syndrome 9.7

Graphical network of the top 20 diseases related to Tularemia:



Diseases related to Tularemia

Symptoms & Phenotypes for Tularemia

Drugs & Therapeutics for Tularemia

Drugs for Tularemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase II Tularemia Vaccine Comparison Completed NCT01150695 Phase 2
2 Safety and Immunogenicity Study of a Live Francisella Tularensis Vaccine Completed NCT00584844 Phase 2
3 Continued Safety and Immunogenicity Study of a Live Francisella Tularensis Vaccine Enrolling by invitation NCT00787826 Phase 2

Search NIH Clinical Center for Tularemia

Cochrane evidence based reviews: tularemia

Genetic Tests for Tularemia

Anatomical Context for Tularemia

MalaCards organs/tissues related to Tularemia:

38
Skin, Lymph Node, Testes, T Cells, Myeloid, Neutrophil, Lung

Publications for Tularemia

Articles related to Tularemia:

(show top 50) (show all 618)
# Title Authors Year
1
Re-emerging Tularemia in Some Middle East Countries: What Are the Reasons? ( 29445647 )
2018
2
Simultaneous immunodetection of anthrax, plague and tularemia from blood cultures utilizing multiplexed suspension arrays. ( 29386263 )
2018
3
Evaluation of In-House and Commercial Serological Tests for Diagnosis of Human Tularemia. ( 29118164 )
2018
4
Tularemia in interepidemic period. ( 29054578 )
2018
5
A Field Study of Plague and Tularemia in Rodents, Western Iran. ( 28165869 )
2017
6
Tularemia presenting as pulmonary nodules in an immunocompromised patient. ( 28405072 )
2017
7
Clinical Characteristics of Ulceroglandular Tularemia in Two Bulgarian Regions, 2014-2015: a Report of Five Cases. ( 29341950 )
2017
8
Usefulness of a single-assay chemiluminescence test (Tularaemia VIRCLIA IgGa88+a88IgM monotest) for the diagnosis of human tularemia. Comparison of five serological tests. ( 29280085 )
2017
9
The Natural History of Pneumonic Tularemia in Female Fischer 344 Rats after Inhalational Exposure to Aerosolized Francisella tularensis Subspecies tularensis Strain SCHU S4. ( 27939130 )
2017
10
Severe glandular tularemia in a patient treated with anti-tumour necrosis factor for psoriatic arthritis. ( 28450199 )
2017
11
Notes from the Field: Fatal Pneumonic Tularemia Associated with Dog Exposure - Arizona, June 2016. ( 28837551 )
2017
12
Human Cases of Tularemia in Armenia, 1996-2012. ( 28722639 )
2017
13
Tularemia ( 28613655 )
2017
14
Necroptotic debris including damaged mitochondria elicits sepsis-like syndrome during late-phase tularemia. ( 28955505 )
2017
15
Introduction and persistence of tularemia in Bulgaria. ( 28649303 )
2017
16
Protection of vaccinated mice against pneumonic tularemia is associated with an early memory sentinel-response in the lung. ( 29102170 )
2017
17
Expansion and retention of pulmonary CD4(+) T cells after prime boost vaccination correlates with improved longevity and strength of immunity against tularemia. ( 28372827 )
2017
18
Tularemia presenting as suspected necrotic arachnidism. ( 28396776 )
2017
19
Atypical Presentations of Tularemia. ( 28813752 )
2017
20
Irruptive mammal host populations shape tularemia epidemiology. ( 29145508 )
2017
21
Sulfonamide inhibition profiles of the I^-carbonic anhydrase from the pathogenic bacterium Francisella tularensis responsible of the febrile illness tularemia. ( 28511911 )
2017
22
Anion inhibitors of the I^-carbonic anhydrase from the pathogenic bacterium responsible of tularemia, Francisella tularensis. ( 28754318 )
2017
23
Imaging Findings of Ulceroglandular Tularemia. ( 28580063 )
2017
24
High-risk regions and outbreak modelling of tularemia in humans. ( 27806741 )
2017
25
Variation in Tularemia Clinical Manifestations-Arkansas, 2009-2013. ( 28480295 )
2017
26
Rare Cause of Pleuropnemonia: Tularemia Disease. ( 29017676 )
2017
27
A spontaneous mutation in kdsD, a biosynthesis gene for 3 Deoxy-D-manno-Octulosonic Acid, occurred in a ciprofloxacin resistant strain of Francisella tularensis and caused a high level of attenuation in murine models of tularemia. ( 28328947 )
2017
28
Prevalence and Seasonality of Fleas Associated With California Ground Squirrels and the Potential Risk of Tularemia in an Outdoor Non-Human Primate Research Facility. ( 29202201 )
2017
29
Tularemia vaccine: Safety, reactogenicity, "Take" skin reactions, and antibody responses following vaccination with a new lot of the Francisella tularensis live vaccine strain - A phase 2 randomized clinical Trial. ( 28750854 )
2017
30
First case of severe pneumonic tularemia in an immunocompetent patient in the Netherlands. ( 28956784 )
2017
31
Lipoxin A4, a 5-lipoxygenase pathway metabolite, modulates immune response during acute respiratory tularemia. ( 27630217 )
2016
32
Respiratory Tularemia: Francisella Tularensis and Microarray Probe Designing. ( 28077973 )
2016
33
Towards development of improved serodiagnostics for tularemia using Francisella tularensis proteome microarrays. ( 27098957 )
2016
34
The prevalence of tularemia in occupational groups that have contact with animals. ( 27511510 )
2016
35
Vaccination evokes gender-dependent protection against tularemia infection in C57BL/6Tac mice. ( 27182819 )
2016
36
Redox-Triggered Release of Moxifloxacin from Mesoporous Silica Nanoparticles Functionalized with Disulfide Snap-Tops Enhances Efficacy Against Pneumonic Tularemia in Mice. ( 27246117 )
2016
37
Respiratory and oral vaccination improves protection conferred by the live vaccine strain against pneumonic tularemia in the rabbit model. ( 27511964 )
2016
38
Inflammasome-Independent NLRP3 Restriction of a Protective Early Neutrophil Response to Pulmonary Tularemia. ( 27926940 )
2016
39
Ultrasonography and contrast-enhanced CT findings of tularemia in the neck. ( 27498683 )
2016
40
Ecology of Tularemia in Central US Endemic Region. ( 27525215 )
2016
41
An Immature Myeloid/Myeloid-Suppressor Cell Response Associated with Necrotizing Inflammation Mediates Lethal Pulmonary Tularemia. ( 27015566 )
2016
42
ECO-EPIZOOTIOLOGIC STUDY OF FRANCISELLA TULARENSIS, THE AGENT OF TULAREMIA, IN QUA8BEC WILDLIFE. ( 26967133 )
2016
43
Tularemia vaccines. ( 27194547 )
2016
44
Ulceroglandular Tularemia Following Contact with a Boar. ( 26658527 )
2016
45
Cluster of ulceroglandular tularemia cases in Slovenia. ( 27496749 )
2016
46
Intracellular Delivery: Redox-Triggered Release of Moxifloxacin from Mesoporous Silica Nanoparticles Functionalized with Disulfide Snap-Tops Enhances Efficacy Against Pneumonic Tularemia in Mice (Small 27/2016). ( 27412305 )
2016
47
Tularemia. ( 28088821 )
2016
48
MBL, P2X7, and SLC11A1 gene polymorphisms in patients with oropharyngeal tularemia. ( 27223255 )
2016
49
Rabbit hunter uveitis: case report of tularemia uveitis. ( 27585457 )
2016
50
A Bioluminescent Francisella tularensis SCHU S4 Strain Enables Noninvasive Tracking of Bacterial Dissemination and the Evaluation of Antibiotics in an Inhalational Mouse Model of Tularemia. ( 27671061 )
2016

Variations for Tularemia

Expression for Tularemia

Search GEO for disease gene expression data for Tularemia.

Pathways for Tularemia

Pathways related to Tularemia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.86 AIM2 CASP1 P2RX7
2 10.57 AIM2 CASP1

GO Terms for Tularemia

Cellular components related to Tularemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 AIM2 inflammasome complex GO:0097169 8.62 AIM2 CASP1

Biological processes related to Tularemia according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.76 AIM2 P2RX7 SLC11A1 TLR2
2 defense response to bacterium GO:0042742 9.71 MBL2 SLC11A1 STAB2
3 response to hypoxia GO:0001666 9.67 CASP1 PPARA TLR2
4 response to lipopolysaccharide GO:0032496 9.62 CASP1 P2RX7 SLC11A1 TLR2
5 positive regulation of interleukin-6 production GO:0032755 9.56 P2RX7 TLR2
6 iron ion homeostasis GO:0055072 9.55 FTL SLC11A1
7 positive regulation of phagocytosis GO:0050766 9.52 MBL2 SLC11A1
8 positive regulation of cytokine secretion GO:0050715 9.51 CASP1 P2RX7
9 response to ATP GO:0033198 9.48 CASP1 P2RX7
10 iron ion transport GO:0006826 9.43 FTL SLC11A1
11 positive regulation of interleukin-1 beta production GO:0032731 9.4 AIM2 P2RX7
12 pyroptosis GO:0070269 9.37 AIM2 CASP1
13 response to bacterium GO:0009617 9.33 CASP1 P2RX7 SLC11A1
14 positive regulation of interleukin-1 alpha secretion GO:0050717 9.26 CASP1 P2RX7
15 positive regulation of interleukin-1 beta secretion GO:0050718 9.13 AIM2 CASP1 P2RX7
16 defense response to Gram-positive bacterium GO:0050830 8.92 MBL2 P2RX7 STAB2 TLR2

Molecular functions related to Tularemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 receptor activity GO:0004872 9.13 P2RX7 PPARA TLR2
2 lipopolysaccharide binding GO:0001530 8.62 P2RX7 TLR2

Sources for Tularemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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