MCID: TLR001
MIFTS: 41

Tularemia

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Tularemia

MalaCards integrated aliases for Tularemia:

Name: Tularemia 12 50 56 3 42 14 69
Francisella Tularensis Infection 50
Pahvant Valley Plague 50
Deerfly Fever 50
Lemming Fever 50
Ohara Disease 50
Rabbit Fever 50
Yatobyo 50

Characteristics:

Orphanet epidemiological data:

56
tularemia
Prevalence: 1-9/1000000 (Europe),<1/1000000 (United Kingdom),<1/1000000 (Netherlands),1-9/100000 (Sweden),1-9/100000 (Czech Republic),1-9/100000 (Finland),1-9/1000000 (Austria),<1/1000000 (Belgium),<1/1000000 (Denmark),1-9/1000000 (Croatia),1-9/1000000 (Bulgaria),<1/1000000 (Estonia),<1/1000000 (France),<1/1000000 (Germany),<1/1000000 (Italy),1-9/1000000 (Latvia),<1/1000000 (Lithuania),<1/1000000 (Poland),<1/1000000 (Romania),<1/1000000 (Slovenia),1-9/1000000 (Switzerland),1-9/1000000 (Spain),1-9/100000 (Norway); Age of onset: All ages; Age of death: any age;

Classifications:

Orphanet: 56  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:2123
ICD9CM 35 021.8
MeSH 42 D014406
Orphanet 56 ORPHA3392
MESH via Orphanet 43 D014406
UMLS via Orphanet 70 C0041351
ICD10 via Orphanet 34 A21.0 A21.1 A21.2 more
UMLS 69 C0029835

Summaries for Tularemia

NIH Rare Diseases : 50 tularemia is an infection common in wild rodents caused by the bacterium francisella tularensis. it is transmitted to humans by contact with infected animal tissues or by ticks, biting flies, and mosquitoes. the condition is most common in north america and parts of europe and asia. it is very rare in the united states. the illness, which is characterized by fever, chills, headache, joint pain and muscle weakness, may continue for several weeks after symptoms begin. streptomycin and tetracycline are commonly used to treat the infection. last updated: 5/10/2010

MalaCards based summary : Tularemia, also known as francisella tularensis infection, is related to pneumonic tularemia and ulceroglandular tularemia. An important gene associated with Tularemia is SLC11A1 (Solute Carrier Family 11 Member 1), and among its related pathways/superpathways are Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways and Nucleotide-binding Oligomerization Domain (NOD) pathway. The drug Vaccines has been mentioned in the context of this disorder. Affiliated tissues include lymph node, testes and skin.

CDC : 3 Tularemia is a disease of animals and humans caused by the bacterium Francisella tularensis. Rabbits, hares, and rodents are especially susceptible and often die in large numbers during outbreaks. Humans can become infected through several routes, including:

Disease Ontology : 12 A primary bacterial infectious disease that has material basis in Francisella tularensis, which is transmitted_by dog tick bite (Dermacentor variabilis), transmitted_by deer flies (Chrysops sp) or transmitted_by contact with infected animal tissues.

Wikipedia : 72 Tularemia is a serious infectious disease caused by the intracellular bacterium Francisella tularensis.... more...

Related Diseases for Tularemia

Diseases related to Tularemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 78)
id Related Disease Score Top Affiliating Genes
1 pneumonic tularemia 12.2
2 ulceroglandular tularemia 12.1
3 oculoglandular tularemia 12.1
4 glandular tularemia 12.1
5 typhoidal tularemia 12.1
6 gastrointestinal tularemia 12.0
7 tick infestation 11.1
8 prothrombin thrombophilia 10.4 MBL2 TLR2
9 not otherwise specified 3-mga-uria type 10.4 SLC11A1 TLR2
10 neonatal meningitis 10.4 MBL2 TLR2
11 epidermolysis bullosa dystrophica, ad 10.3 MBL2 TLR2
12 endogenous depression 10.3 MBL2 TLR2
13 tinea barbae 10.2 MBL2 TLR2
14 atypical teratoid rhabdoid tumor 10.1 FTL STAB2 TLR2
15 cervicitis 10.1
16 schneiderian carcinoma 10.1 MBL2 SLC11A1 TLR2
17 plague 10.1
18 lymphadenitis 10.1
19 pneumonia 10.1
20 rift valley fever 10.0 CASP1 SLC11A1
21 opportunistic bacterial infectious disease 10.0 PDE6B SLC11A1 TLR2
22 askin's tumor 9.9 MBL2 P2RX7 SLC11A1 TLR2
23 cockayne syndrome 9.9 MBL2 P2RX7 SLC11A1 TLR2
24 pericardium disease 9.9 MBL2 TLR2
25 q fever 9.9
26 leptospirosis 9.9
27 spotted fever 9.9
28 hepatitis 9.8
29 pharyngitis 9.8
30 rocky mountain spotted fever 9.8
31 influenza 9.8
32 brucellosis 9.8
33 nasopharyngitis 9.8 CASP1 TLR2
34 tick paralysis 9.7
35 transmitted_by 9.7
36 tuberculosis 9.7
37 lymphoma 9.7
38 endocarditis 9.7
39 smallpox 9.7
40 meningitis 9.7
41 spermatic cord torsion 9.7 CASP1 PDE6B STAB2
42 aspartylglucosaminuria 9.6 HSPE1 SLC11A1 TLR2
43 arthritis 9.5
44 neuritis 9.5
45 encephalitis 9.5
46 chronic granulomatous disease 9.5
47 coccidiosis 9.5
48 dacryocystitis 9.5
49 rabies 9.5
50 toxoplasmosis 9.5

Graphical network of the top 20 diseases related to Tularemia:



Diseases related to Tularemia

Symptoms & Phenotypes for Tularemia

Drugs & Therapeutics for Tularemia

Drugs for Tularemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Phase II Tularemia Vaccine Comparison Completed NCT01150695 Phase 2
2 Safety and Immunogenicity Study of a Live Francisella Tularensis Vaccine Completed NCT00584844 Phase 2
3 Continued Safety and Immunogenicity Study of a Live Francisella Tularensis Vaccine Enrolling by invitation NCT00787826 Phase 2

Search NIH Clinical Center for Tularemia

Cochrane evidence based reviews: tularemia

Genetic Tests for Tularemia

Anatomical Context for Tularemia

MalaCards organs/tissues related to Tularemia:

39
Lymph Node, Testes, Skin, T Cells, Myeloid, Liver, Whole Blood

Publications for Tularemia

Articles related to Tularemia:

(show top 50) (show all 606)
id Title Authors Year
1
Sulfonamide inhibition profiles of the I^-carbonic anhydrase from the pathogenic bacterium Francisella tularensis responsible of the febrile illness tularemia. ( 28511911 )
2017
2
High-risk regions and outbreak modelling of tularemia in humans. ( 27806741 )
2017
3
Tularemia presenting as suspected necrotic arachnidism. ( 28396776 )
2017
4
A spontaneous mutation in kdsD, a biosynthesis gene for 3 Deoxy-D-manno-Octulosonic Acid, occurred in a ciprofloxacin resistant strain of Francisella tularensis and caused a high level of attenuation in murine models of tularemia. ( 28328947 )
2017
5
Tularemia vaccine: Safety, reactogenicity, "Take" skin reactions, and antibody responses following vaccination with a new lot of the Francisella tularensis live vaccine strain - A phase 2 randomized clinical Trial. ( 28750854 )
2017
6
Variation in Tularemia Clinical Manifestations-Arkansas, 2009-2013. ( 28480295 )
2017
7
Human Cases of Tularemia in Armenia, 1996-2012. ( 28722639 )
2017
8
Tularemia presenting as pulmonary nodules in an immunocompromised patient. ( 28405072 )
2017
9
Severe glandular tularemia in a patient treated with anti-tumour necrosis factor for psoriatic arthritis. ( 28450199 )
2017
10
The Natural History of Pneumonic Tularemia in Female Fischer 344 Rats after Inhalational Exposure to Aerosolized Francisella tularensis Subspecies tularensis Strain SCHU S4. ( 27939130 )
2017
11
Introduction and persistence of tularemia in Bulgaria. ( 28649303 )
2017
12
Expansion and retention of pulmonary CD4(+) T cells after prime boost vaccination correlates with improved longevity and strength of immunity against tularemia. ( 28372827 )
2017
13
Notes from the Field: Fatal Pneumonic Tularemia Associated with Dog Exposure - Arizona, June 2016. ( 28837551 )
2017
14
Imaging Findings of Ulceroglandular Tularemia. ( 28580063 )
2017
15
A Field Study of Plague and Tularemia in Rodents, Western Iran. ( 28165869 )
2017
16
Anion inhibitors of the I^-carbonic anhydrase from the pathogenic bacterium responsible of tularemia, Francisella tularensis. ( 28754318 )
2017
17
Tularemia ( 28613655 )
2017
18
Atypical Presentations of Tularemia. ( 28813752 )
2017
19
Tularemia. ( 28088821 )
2016
20
Tularemia Masquerading as Ecthyma. ( 27562918 )
2016
21
Lipoxin A4, a 5-lipoxygenase pathway metabolite, modulates immune response during acute respiratory tularemia. ( 27630217 )
2016
22
First Pediatric Case of Tularemia after a Coyote Bite. ( 26885419 )
2016
23
Vaccination evokes gender-dependent protection against tularemia infection in C57BL/6Tac mice. ( 27182819 )
2016
24
The prevalence of tularemia in occupational groups that have contact with animals. ( 27511510 )
2016
25
An Immature Myeloid/Myeloid-Suppressor Cell Response Associated with Necrotizing Inflammation Mediates Lethal Pulmonary Tularemia. ( 27015566 )
2016
26
Tularemia vaccines. ( 27194547 )
2016
27
Inflammasome-Independent NLRP3 Restriction of a Protective Early Neutrophil Response to Pulmonary Tularemia. ( 27926940 )
2016
28
Towards development of improved serodiagnostics for tularemia using Francisella tularensis proteome microarrays. ( 27098957 )
2016
29
MBL, P2X7, and SLC11A1 gene polymorphisms in patients with oropharyngeal tularemia. ( 27223255 )
2016
30
Predicting tularemia with clinical, laboratory and demographical findings in the ED. ( 26577431 )
2016
31
Tularemia vaccine development: paralysis or progress? ( 27200274 )
2016
32
Ecology of Tularemia in Central US Endemic Region. ( 27525215 )
2016
33
Ultrasonography and contrast-enhanced CT findings of tularemia in the neck. ( 27498683 )
2016
34
Redox-Triggered Release of Moxifloxacin from Mesoporous Silica Nanoparticles Functionalized with Disulfide Snap-Tops Enhances Efficacy Against Pneumonic Tularemia in Mice. ( 27246117 )
2016
35
ECO-EPIZOOTIOLOGIC STUDY OF FRANCISELLA TULARENSIS, THE AGENT OF TULAREMIA, IN QUA8BEC WILDLIFE. ( 26967133 )
2016
36
Respiratory Tularemia: Francisella Tularensis and Microarray Probe Designing. ( 28077973 )
2016
37
Cluster of ulceroglandular tularemia cases in Slovenia. ( 27496749 )
2016
38
Respiratory and oral vaccination improves protection conferred by the live vaccine strain against pneumonic tularemia in the rabbit model. ( 27511964 )
2016
39
Phylogeography of Francisella tularensis from Tibet, China: Evidence for an asian origin and radiation of holarctica-type Tularemia. ( 27150591 )
2016
40
Introduction and persistence of tularemia in Bulgaria. ( 27790972 )
2016
41
Spatio-temporal dynamics of tularemia in French wildlife: 2002-2013. ( 27435644 )
2016
42
Intracellular Delivery: Redox-Triggered Release of Moxifloxacin from Mesoporous Silica Nanoparticles Functionalized with Disulfide Snap-Tops Enhances Efficacy Against Pneumonic Tularemia in Mice (Small 27/2016). ( 27412305 )
2016
43
Rabbit hunter uveitis: case report of tularemia uveitis. ( 27585457 )
2016
44
A Bioluminescent Francisella tularensis SCHU S4 Strain Enables Noninvasive Tracking of Bacterial Dissemination and the Evaluation of Antibiotics in an Inhalational Mouse Model of Tularemia. ( 27671061 )
2016
45
Ulceroglandular Tularemia Following Contact with a Boar. ( 26658527 )
2016
46
Zoonotic occupational diseases in forestry workers - Lyme borreliosis, tularemia and leptospirosis in Europe. ( 25780827 )
2015
47
Prospective investigation of the hypothalamo-pituitary-adrenal axis in patients with tularemia. ( 26281320 )
2015
48
About three cases of ulceroglandular tularemia, is this the re-emergence of F. tularensis in Belgium? ( 25847026 )
2015
49
Ciprofloxacin: Tularemia (Adults). ( 26448657 )
2015
50
Successful protection against tularemia in C57BL/6 mice is correlated with expansion of Francisella tularensis-specific effector T cells. ( 25410207 )
2015

Variations for Tularemia

Expression for Tularemia

Search GEO for disease gene expression data for Tularemia.

Pathways for Tularemia

Pathways related to Tularemia according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
10.86 AIM2 CASP1 P2RX7
2 10.57 AIM2 CASP1

GO Terms for Tularemia

Cellular components related to Tularemia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 AIM2 inflammasome complex GO:0097169 8.62 AIM2 CASP1

Biological processes related to Tularemia according to GeneCards Suite gene sharing:

(show all 15)
id Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.76 AIM2 P2RX7 SLC11A1 TLR2
2 defense response to bacterium GO:0042742 9.71 MBL2 SLC11A1 STAB2
3 response to hypoxia GO:0001666 9.67 CASP1 PPARA TLR2
4 defense response to Gram-positive bacterium GO:0050830 9.58 MBL2 P2RX7 TLR2
5 response to lipopolysaccharide GO:0032496 9.56 CASP1 P2RX7 SLC11A1 TLR2
6 iron ion homeostasis GO:0055072 9.55 FTL SLC11A1
7 positive regulation of phagocytosis GO:0050766 9.52 MBL2 SLC11A1
8 positive regulation of cytokine secretion GO:0050715 9.51 CASP1 P2RX7
9 response to ATP GO:0033198 9.48 CASP1 P2RX7
10 iron ion transport GO:0006826 9.43 FTL SLC11A1
11 positive regulation of interleukin-1 beta production GO:0032731 9.37 AIM2 P2RX7
12 pyroptosis GO:0070269 9.32 AIM2 CASP1
13 positive regulation of interleukin-1 alpha secretion GO:0050717 9.16 CASP1 P2RX7
14 response to bacterium GO:0009617 9.13 CASP1 P2RX7 SLC11A1
15 positive regulation of interleukin-1 beta secretion GO:0050718 8.8 AIM2 CASP1 P2RX7

Molecular functions related to Tularemia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 receptor activity GO:0004872 9.13 P2RX7 PPARA TLR2
2 lipopolysaccharide binding GO:0001530 8.62 P2RX7 TLR2

Sources for Tularemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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