MCID: TLR001
MIFTS: 44

Tularemia malady

Rare diseases, Infectious diseases categories

Aliases & Classifications for Tularemia

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Sources:
10Disease Ontology, 45NIH Rare Diseases, 12DISEASES, 51Orphanet, 2CDC, 65UMLS, 59SNOMED-CT, 29ICD9CM, 28ICD10 via Orphanet, 37MESH via Orphanet, 66UMLS via Orphanet
See all sources

Aliases & Descriptions for Tularemia:

Name: Tularemia 10 45 12 51 2 65
Francisella Tularensis Infection 45
Pahvant Valley Plague 45
Deerfly Fever 45
 
Ohara Disease 45
Lemming Fever 45
Rabbit Fever 45
Yatobyo 45


Classifications:



External Ids:

Disease Ontology10 DOID:2123
ICD9CM29 021.8
Orphanet51 3392
ICD10 via Orphanet28 A21.3, A21.7, A21.8 A21.9, A21.0, A21.1, A21.2, more
MESH via Orphanet37 D014406
UMLS via Orphanet66 C0041351

Summaries for Tularemia

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NIH Rare Diseases:45 Tularemia is an infection common in wild rodents caused by the bacterium francisella tularensis. it is transmitted to humans by contact with infected animal tissues or by ticks, biting flies, and mosquitoes. the condition is most common in north america and parts of europe and asia. it is very rare in the united states. the illness, which is characterized by fever, chills, headache, joint pain and muscle weakness, may continue for several weeks after symptoms begin. streptomycin and tetracycline are commonly used to treat the infection. last updated: 5/10/2010

MalaCards based summary: Tularemia, also known as francisella tularensis infection, is related to ulceroglandular tularemia and pneumonic tularemia. An important gene associated with Tularemia is PPARA (Peroxisome Proliferator-Activated Receptor Alpha), and among its related pathways are NTHi-Induced Signaling and TRAF Pathway. Affiliated tissues include testes, t cells and skin, and related mouse phenotypes are muscle and renal/urinary system.

Disease Ontology:10 A primary bacterial infectious disease that has material basis in francisella tularensis, which is transmitted by dog tick bite (dermacentor variabilis), transmitted by deer flies (chrysops sp) or transmitted by contact with infected animal tissues.

CDC:2 Tularemia is a disease of animals and humans caused by the bacterium Francisella tularensis. Rabbits, hares, and rodents are especially susceptible and often die in large numbers during outbreaks. Humans can become infected through several routes, including:

Wikipedia:68 Tularemia (or tularaemia; also known as Pahvant Valley plague,rabbit fever,deer fly fever, and Ohara\'s... more...

Related Diseases for Tularemia

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Graphical network of the top 20 diseases related to Tularemia:



Diseases related to tularemia

Symptoms for Tularemia

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Drugs & Therapeutics for Tularemia

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Drugs for Tularemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Ampicillinapproved5069-53-46249
Synonyms:
(2S,5R,6R)-6-[[(2R)-2-amino-2-phenylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
(2S,5R,6R)-6-{[(2R)-2-amino-2-phenylacetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
(2S,5R,6R)-6-{[(2R)-2-amino-2-phenylethanoyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
1h8s
33604-21-6
37234-64-3
47355-94-2
50584-05-9
6-(D(-)-alpha-Aminophenylacetamido)penicillanic acid
6-(D-(2-amino-2-Phenylacetamido))-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid
6-(a-Aminophenylacetamido)penicillanic acid
6-D(-)-alpha-Aminophenylacetamido-penicillanic acid
6-[(Aminophenylacetyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 9CI
69-52-3 (mono-hydrochloride salt)
69-53-4
6beta-[(2R)-2-amino-2-phenylacetamido]-2,2-dimethylpenam-3alpha-carbonyl
6beta-[(2R)-2-amino-2-phenylacetamido]-2,2-dimethylpenam-3alpha-carboxylic acid
7177-48-2 (TRIHYDRATE)
800-79-3
8056-87-9
96707-69-6
98520-55-9
A9393_SIGMA
AB-PC
AB-PC Sol
ABPC
AC-14075
AC1L1M46
AMP
AMPI
AMPICILLIN (SEE ALSO AMPICILLIN TRIHYDRATE 7177-48-2)
AP
AY 6108
AY 6108
AY-6108
Acillin
Adobacillin
Alpen
Amblosin
Amcill
Amfipen
Amfipen V
Amfipen v
Aminobenzylpenicillin
Amipenix S
Ampen
Ampi-Co
Ampi-Tab
Ampi-bol
Ampi-co
Ampi-tab
Ampichel
Ampicil
Ampicilina
Ampicilina [INN-Spanish]
Ampicillin
Ampicillin (USP/INN)
Ampicillin A
Ampicillin Acid
Ampicillin Anhydrate
Ampicillin Anhydrous
Ampicillin Base
Ampicillin Sodium
Ampicillin Trihydrate
Ampicillin [USAN:BAN:INN:JAN]
Ampicillin [USAN:INN:BAN:JAN]
Ampicillin [Usan:Ban:Inn:Jan]
Ampicillin acid
Ampicillin anhydrate
Ampicillin sodium
Ampicillina
Ampicillina [DCIT]
Ampicillina [Dcit]
Ampicilline
Ampicilline [INN-French]
Ampicillinum
Ampicillinum [INN-Latin]
Ampicin
Ampifarm
Ampikel
Ampimed
Ampipenin
Ampipenin, nt3
Ampiscel
Ampisyn
Ampivax
Ampivet
Amplacilina
Amplin
Amplipenyl
Amplisom
Amplital
Ampy-Penyl
Anhydrous Ampicillin
Anhydrous ampicillin
Anhydrous ampicillin (JP15)
Austrapen
BA 7305
BIDD:GT0184
BPBio1_000142
BRL 1341
BRL-1341
BSPBio_000128
BSPBio_001862
Bayer 5427
Binotal
Bonapicillin
Britacil
C06574
CHEBI:28971
CHEBI:53713
CHEMBL174
CID6249
Campicillin
Cimex
Copharcilin
D-(-)-6-(alpha-Aminophenylacetamido)penicillanic acid
D-(-)-6-(alpha-aminophenylacetamido)penicillanic acid
D-(-)-Ampicillin
D-(-)-alpha-Aminobenzylpenicillin
D-(-)-alpha-Aminopenicillin
D-(-)-ampicillin
D-(−)-6-(α-aminophenylacetamido)penicillanic acid
D-(−)-ampicillin
D-Ampicillin
D-Cillin
D-a-Aminobenzylpenicillin
D00204
DB00415
Delcillin
Deripen
 
DivK1c_000466
Divercillin
Doktacillin
Duphacillin
EINECS 200-709-7
Geocillin
Grampenil
Guicitrina
Guicitrine
HI 63
HMS2090I11
HSDB 3009
IDI1_000466
KBio1_000466
KBio2_000430
KBio2_002998
KBio2_005566
KBio3_001362
KBioGR_000598
KBioSS_000430
KS-R1
LS-1586
LS-169948
Lifeampil
MLS000028405
MLS001074168
Magnapen
Marcillin
MolPort-001-794-635
Morepen
NCGC00023282-05
NCGC00023282-06
NINDS_000466
NSC 528986
NSC-528986
NSC528986
Norobrittin
Novo-ampicillin
Nuvapen
OMNIPEN (AMPICILLIN)
Olin Kid
Olin kid
Omnipen
Omnipen (TN)
Omnipen-N
Orbicilina
P 50
P-50
Pen A
Pen A Oral
Pen Ampil
Pen a
Pen ampil
Penbristol
Penbritin
Penbritin paediatric
Penbritin syrup
Penbritin-S
Penbrock
Penicillin, Aminobenzyl
Penicline
Penimic
Pensyn
Pentrex
Pentrexl
Pentrexyl
Pentritin
Pfizerpen A
Pfizerpen a
Pfizerpen-A
Polycillin
Polycillin-N
Polyflex (Veterinary)
Ponecil
Prestwick0_000114
Prestwick1_000114
Prestwick2_000114
Prestwick3_000114
Princillin
Principen
Principen '125'
Principen '250'
Principen '500'
QIDamp
Qidamp
Racenacillin
Ro-Ampen
Ro-ampen
Rosampline
Roscillin
SBB063111
SK-Ampicillin
SK-ampicillin
SMP1_000211
SMR000058352
SPBio_000818
SPBio_002067
SQ 17382
Semicillin
Semicillin R
Servicillin
Spectrum2_000769
Spectrum3_000301
Spectrum4_000149
Spectrum5_000814
Spectrum_000050
Sumipanto
Supen
Synpenin
Texcillin
Tokiocillin
Tolomol
Totacillin
Totacillin (sodium)
Totacillin-N
Totalciclina
Totapen
Trifacilina
UNII-7C782967RD
Ukapen
Ultrabion
Ultrabron
Vampen
Viccillin
Viccillin S
Vidocillin
Vidopen
WY-5103
Wypicil
alpha-Aminobenzylpenicillin
ampicillanyl
ampicillin
anhydrous ampicillin
2Emetics159

Interventional clinical trials:

idNameStatusNCT IDPhase
1Phase II Tularemia Vaccine ComparisonCompletedNCT01150695Phase 2
2Safety and Immunogenicity Study of a Live Francisella Tularensis VaccineCompletedNCT00584844Phase 2
3Continued Safety and Immunogenicity Study of a Live Francisella Tularensis VaccineEnrolling by invitationNCT00787826Phase 2
4Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of CareRecruitingNCT01431326

Search NIH Clinical Center for Tularemia

Genetic Tests for Tularemia

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Anatomical Context for Tularemia

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MalaCards organs/tissues related to Tularemia:

33
Testes, T cells, Skin, Liver, Whole blood, Kidney, Lymph node

Animal Models for Tularemia or affiliated genes

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MGI Mouse Phenotypes related to Tularemia:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.1HSPD1, MAN2B1, PPARA, STAB2, TLR2
2MP:00053677.6CASP1, MAN2B1, MYD88, STAB2, TLR2
3MP:00053857.1CASP1, MAN2B1, MYD88, PDE6B, PPARA, STAB2
4MP:00053847.1CASP1, HSPD1, MAN2B1, MYD88, PDE6B, PPARA

Publications for Tularemia

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Articles related to Tularemia:

(show top 50)    (show all 551)
idTitleAuthorsYear
1
Francisella tularensis LVS surface and membrane proteins as targets of effective post-exposure immunization for tularemia. (25494920)
2015
2
Tuberculosis or tularemia? A molecular study in cervical lymphadenitis. (24239221)
2014
3
The potential of liposome-encapsulated ciprofloxacin as a tularemia therapy. (24995163)
2014
4
Francisella tularensis bacteria associated with feline tularemia in the United States. (25424732)
2014
5
Tularemia: a re-emerging condition in Turkey which may be related with contaminated spring water in rural areas. (24190761)
2014
6
Tularemia during pregnancy: report of four cases. (22998506)
2013
7
Granulomatous lymphadenitis can also be seen in tularemia, not only in tuberculosis. (23219034)
2013
8
Unilateral acute dacryocystitis associated with oculoglandular tularemia: a case report. (23448564)
2013
9
Guillain-BarrAc syndrome and ulceroglandular tularemia. (23896779)
2013
10
Post-exposure immunization against Francisella tularensis membrane proteins augments protective efficacy of gentamicin in a mouse model of pneumonic tularemia. (22652404)
2012
11
Tularemia progression accompanied with oxidative stress and antioxidant alteration in spleen and liver of BALB/c mice. (22752903)
2012
12
Two cases of glandular tularemia from Turkey. (22734313)
2012
13
Pneumonic tularemia in rabbits resembles the human disease as illustrated by radiographic and hematological changes after infection. (21931798)
2011
14
Oropharyngeal tularemia mimicking tumoral relapse in a patient with Hodgkin lymphoma in remission. (21853659)
2011
15
Development of tolerogenic dendritic cells and regulatory T cells favors exponential bacterial growth and survival during early respiratory tularemia. (21724804)
2011
16
Real-time PCR for diagnosis of oculoglandular tularemia. (20031067)
2010
17
Glycogen synthase kinase-3beta (GSK3beta) inhibition suppresses the inflammatory response to Francisella infection and protects against tularemia in mice. (18929413)
2009
18
Water-borne outbreak of oropharyngeal and glandular tularemia in Georgia: investigation and follow-up. (19826763)
2009
19
Tularemia, plague, yersiniosis, and Tyzzer's disease in wild rodents and lagomorphs in Canada: a review. (20190973)
2009
20
Landscape epidemiology of tularemia outbreaks in Sweden. (19961673)
2009
21
Assessment of low-molecular-weight antioxidants in Francisella tularensis infected hosts: comparison of two rodents with different susceptibility to tularemia. (20027169)
2009
22
Tularemia in range sheep: an overlooked syndrome? (18599860)
2008
23
Generation and characterization of hybridoma antibodies for immunotherapy of tularemia. (17764754)
2007
24
Diagnosis of tularemia using piezoelectric biosensor technology. (19071403)
2007
25
Comparison of the 2000 and 2005 outbreaks of tularemia in the Duzce region of Turkey. (17314427)
2007
26
Tularemia after a dormouse bite in Switzerland. (15856137)
2005
27
First reported prairie dog-to-human tularemia transmission, Texas, 2002. (15109417)
2004
28
Anthrax, botulism and tularemia in Italy. (12749299)
2003
29
A procedure for differentiating between the intentional release of biological warfare agents and natural outbreaks of disease: its use in analyzing the tularemia outbreak in Kosovo in 1999 and 2000. (12197873)
2002
30
Treatment of tularemia with levofloxacin. (11318818)
2001
31
Ciprofloxacin for treatment of tularemia in children. (10819342)
2000
32
The influence of immunization with tularemia live vaccine on the clastogenic action of cyclophosphamide in mice. (8841489)
1996
33
Field investigations of tularemia in Norway. (8861027)
1996
34
Relapse of tularemia after aminoglycoside therapy: case report and discussion of therapeutic options. (7727647)
1995
35
Tularemia: a differential diagnosis in oto-rhino-laryngology. (8496644)
1993
36
Tularemia pneumonia in Oklahoma, 1982-1987. (1593309)
1992
37
Francisella tularensis-induced in vitro gamma interferon, tumor necrosis factor alpha, and interleukin 2 responses appear within 2 weeks of tularemia vaccination in human beings. (1909711)
1991
38
Influence of genetic background on host resistance to experimental murine tularemia. (3397185)
1988
39
Bronchial changes in airborne tularemia. (3772243)
1986
40
Tick-borne tularemia. An outbreak of lymphadenopathy in children. (4057512)
1985
41
A family outbreak of tularemia. (3842118)
1985
42
Oropharyngeal tularemia. (6572814)
1983
43
Hepatic porphyrias simulating typhoidal tularemia. (7090965)
1982
44
Tularemia: review of eight cases of tick-borne infection and the epidemiology of the disease in Georgia. (7071635)
1982
45
Tick-borne tularemia presenting as ulcerative lymphadenitis. (428180)
1979
46
Cavitary pneumonia associated with tularemia. (630947)
1978
47
One-half century of tularemia in Florida. (1099166)
1975
48
Chronic shedding tularemia nephritis in rodents: possible relation to occurrence of Francisella tularensis in lotic waters. (239255)
1975
49
Bubonic plague misdiagnosed as tularemia. Retrospective serologic diagnosis. (4678367)
1972
50
OCULOGLANDULAR TULAREMIA: TRANSMISSION FROM RABBIT, THROUGH DOG AND TICK TO MAN. (14320040)
1965

Variations for Tularemia

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Expression for genes affiliated with Tularemia

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Search GEO for disease gene expression data for Tularemia.

Pathways for genes affiliated with Tularemia

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Pathways related to Tularemia according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3MYD88, TLR2
2
Show member pathways
8.9CASP1, MYD88, TLR2
38.7HSPD1, MYD88, TLR2
48.3CASP1, HSPD1, MYD88, TLR2

GO Terms for genes affiliated with Tularemia

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Cellular components related to Tularemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1AIM2 inflammasome complexGO:00971699.7AIM2, CASP1

Biological processes related to Tularemia according to GeneCards Suite gene sharing:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of cytokine secretionGO:005071510.2CASP1, TLR2
2nucleotide-binding domain, leucine rich repeat containing receptor signaling pathwayGO:003587210.1AIM2, CASP1
3pyroptosisGO:007026910.1AIM2, CASP1
4positive regulation of interleukin-1 beta secretionGO:005071810.1AIM2, CASP1
5response to molecule of fungal originGO:00022389.9MYD88, TLR2
6positive regulation of interleukin-12 productionGO:00327359.9HSPD1, TLR2
7response to bacteriumGO:00096179.8CASP1, TLR2
8response to peptidoglycanGO:00324949.8MYD88, TLR2
9lipopolysaccharide-mediated signaling pathwayGO:00316639.7MYD88, TLR2
10negative regulation of growth of symbiont in hostGO:00441309.6MYD88, TLR2
11response to ATPGO:00331989.4CASP1, HSPD1
12positive regulation of tumor necrosis factor productionGO:00327609.4MYD88, TLR2
13positive regulation of NF-kappaB transcription factor activityGO:00510929.3AIM2, MYD88, TLR2
14response to hypoxiaGO:00016668.9CASP1, HSPD1, PPARA
15positive regulation of interleukin-6 productionGO:00327558.8HSPD1, MYD88, TLR2
16response to lipopolysaccharideGO:00324968.8CASP1, HSPD1, MYD88
17MyD88-dependent toll-like receptor signaling pathwayGO:00027558.6HSPD1, MYD88, TLR2

Molecular functions related to Tularemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1lipopolysaccharide bindingGO:00015309.5HSPD1, TLR2

Sources for Tularemia

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet