MCID: TLR001
MIFTS: 44

Tularemia malady

Infectious diseases category

Summaries for Tularemia

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8Disease Ontology, 42NIH Rare Diseases, 3CDC, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Tularemia is an infection common in wild rodents caused by the bacterium francisella tularensis. it is transmitted to humans by contact with infected animal tissues or by ticks, biting flies, and mosquitoes. the condition is most common in north america and parts of europe and asia. it is very rare in the united states. the illness, which is characterized by fever, chills, headache, joint pain and muscle weakness, may continue for several weeks after symptoms begin. streptomycin and tetracycline are commonly used to treat the infection. last updated: 5/10/2010

MalaCards: Tularemia, also known as francisella tularensis infection, is related to pneumonia and influenza. An important gene associated with Tularemia is MYD88 (myeloid differentiation primary response 88), and among its related pathways are NTHi-Induced Signaling and Leishmaniasis. The compound flagellin have been mentioned in the context of this disorder. Affiliated tissues include testes, skin and t cells, and related mouse phenotype tumorigenesis.

Disease Ontology:8 A primary bacterial infectious disease that has material basis in francisella tularensis, which is transmitted by dog tick bite (dermacentor variabilis), transmitted by deer flies (chrysops sp) or transmitted by contact with infected animal tissues.

CDC:3 Tularemia is a disease of animals and humans caused by the bacterium Francisella tularensis. Rabbits, hares, and rodents are especially susceptible and often die in large numbers during outbreaks. Humans can become infected through several routes, including:

Wikipedia:63 Tularemia (or tularaemia; also known as Pahvant Valley plague,rabbit fever,deer fly fever, and Ohara\'s... more...

Aliases & Classifications for Tularemia

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 48Orphanet, 60UMLS, 56SNOMED-CT, 27ICD9CM, 35MESH via Orphanet, 57SNOMED-CT via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Aliases & Descriptions:

tularemia 8 42 10 48 60
francisella tularensis infection 42
pahvant valley plague 42
deerfly fever 42
ohara disease 42
lemming fever 42


External Ids:

Disease Ontology8 DOID:2123
ICD9CM27 021.8
MESH via Orphanet35 D014406
SNOMED-CT via Orphanet57 19265001
ICD10 via Orphanet26 A21.0, A21.1, A21.2 A21.3, A21.7, A21.8, A21.9, more
UMLS via Orphanet61 C0041351

Related Diseases for Tularemia

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Tularemia:



Diseases related to tularemia

Clinical Features for Tularemia

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Drugs & Therapeutics for Tularemia

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Tularemia

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Anatomical Context for Tularemia

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32MalaCards
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MalaCards organs/tissues related to Tularemia:

32
Testes, Skin, T cells, Whole blood, Liver, Kidney, Lymph node, Brain, Spleen, Myeloid, B cells

Animal Models for Tularemia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Tularemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.6IL2, MYD88, STAB2, PSME2, TLR2

Publications for Tularemia

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50PubMed
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Articles related to Tularemia:

(show top 50)    (show all 505)
idTitleAuthorsYear
1
Neutrophils: potential therapeutic targets in tularemia? (24409419)
2014
2
Granulomatous lymphadenitis can also be seen in tularemia, not only in tuberculosis. (23219034)
2013
3
Investigation of tularemia outbreak after natural infection of outdoor-housed rhesus macaques (Macaca mulatta) with Francisella tularensis. (23582425)
2013
4
Organs of BALB/c mice can be injured in course of tularemia. (23549511)
2013
5
Seroprevalence of tularemia in rural Azerbaijan. (22452727)
2012
6
Genome sequence of Francisella tularensis subspecies holarctica strain FSC200, isolated from a child with tularemia. (23209222)
2012
7
Identification of Francisella tularensis by both culture and real-time TaqMan PCR methods from environmental water specimens in outbreak areas where tularemia cases were not previously reported. (22382819)
2012
8
Pneumonic tularemia in rabbits resembles the human disease as illustrated by radiographic and hematological changes after infection. (21931798)
2011
9
Longitudinal study on the seroprevalence of avian influenza, leptospirosis, and tularemia in an urban population of raccoons (Procyon lotor) in Ontario, Canada. (20491583)
2011
10
Tularemia in two South Dakota children. (21894744)
2011
11
A galU mutant of Francisella tularensis is attenuated for virulence in a murine pulmonary model of tularemia. (21819572)
2011
12
Tularemia, plague, yersiniosis, and Tyzzer's disease in wild rodents and lagomorphs in Canada: a review. (20190973)
2009
13
Clinical and epidemiological features of tularemia. (19904494)
2009
14
Tularemia type A in captive Bornean orangutans (Pongo pygmaeus pygmaeus). (19569471)
2009
15
Re-emergence of tularemia in Germany: presence of Francisella tularensis in different rodent species in endemic areas. (19014635)
2008
16
Two unusual glandular presentations of tick-borne tularemia. (18191519)
2008
17
Comparison of the 2000 and 2005 outbreaks of tularemia in the Duzce region of Turkey. (17314427)
2007
18
Outbreaks of tularemia in Turkey. (17579300)
2007
19
Tularemia: history, epidemiology, pathogen physiology, and clinical manifestations. (17395726)
2007
20
OSHA compliance issues--exposure to tularemia. (16862710)
2006
21
Endemic tularemia, Sweden, 2003. (16229776)
2005
22
Tularemia: the disease and the weapon. (15207312)
2004
23
Histologic and molecular diagnosis of tularemia: a potential bioterrorism agent endemic to North America. (15001997)
2004
24
Tularemia. (14505277)
2003
25
The 2000 tularemia outbreak: a case-control study of risk factors in disease-endemic and emergent areas, Sweden. (12194773)
2002
26
Tularemia. A pathogen in nature and a biological weapon. (12227212)
2002
27
Ciprofloxacin for treatment of tularemia. (11418893)
2001
28
Tularemia presenting with ataxia. (10619760)
2000
29
Expansion of Vgamma9 Vdelta2 T cells is triggered by Francisella tularensis-derived phosphoantigens in tularemia but not after tularemia vaccination. (9573096)
1998
30
Arthropod-borne tularemia in Japan: clinical analysis of 1,374 cases observed between 1924 and 1996. (9701929)
1998
31
The influence of immunization with tularemia live vaccine on the clastogenic action of cyclophosphamide in mice. (8841489)
1996
32
Index of suspicion. Case 2. Diagnosis: ulceroglandular tularemia. (8992473)
1996
33
Live tularemia vaccine confers protection against lethal Legionella and Listeria infections in experimental animals. (8861031)
1996
34
Similar pleural fluid findings in pleuropulmonary tularemia and tuberculous pleurisy. (8620743)
1996
35
Live tularemia vaccine but not proteins purified from Francisella tularensis can confer protection against lethal Listeria infection in mice. (7748535)
1995
36
Tularemia. (7805415)
1994
37
Passive protection of mice against lethal Francisella tularensis (live tularemia vaccine strain) infection by the sera of human recipients of the live tularemia vaccine. (8042659)
1994
38
Clinical manifestations of tularemia in Japan--analysis of 1,355 cases observed between 1924 and 1987. (2013502)
1991
39
Tularemia in a cat. (2094456)
1990
40
Guillain-BarrAc syndrome and tularemia pleuritis with high adenosine deaminase activity in pleural fluid. (2737756)
1989
41
Tularemia and rhabdomyolysis. (3965776)
1985
42
An outbreak of tularemia in the northern part of central Sweden. (6149615)
1984
43
Skin manifestations of tularemia: a study of 88 cases in northern Finland during 16 years (1967-1983). (6084923)
1984
44
Tularemia in Canada with a focus on Saskatchewan. (7046896)
1982
45
Tularemia, an analysis of 25 cases. (7219406)
1981
46
Oropharyngeal tularemia. (6928749)
1980
47
Pneumonic tularemia on Martha's Vineyard. (481515)
1979
48
Cat-bite tularemia. (578542)
1977
49
Protein synthesis in zinc deficient rats during tularemia. (58980)
1976
50
Pneumonic tularemia following the shearing of a dog. (4672882)
1972

Genetic Variations for Tularemia

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Expression for genes affiliated with Tularemia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Tularemia

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Pathways for genes affiliated with Tularemia

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51QIAGEN, 29KEGG
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Pathways related to Tularemia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0MYD88, TLR2
2
Hide members
9.7IL2, MYD88, TLR2

Compounds for genes affiliated with Tularemia

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44Novoseek, 28IUPHAR
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Compounds related to Tularemia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1flagellin44 2811.0MYD88, TLR2

GO Terms for genes affiliated with Tularemia

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16Gene Ontology
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Biological processes related to Tularemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of interleukin-17 productionGO:03274010.0IL2, MYD88

Products for genes affiliated with Tularemia

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Sources for Tularemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet