MCID: TLR001
MIFTS: 39

Tularemia malady

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Tularemia

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Sources:
2CDC, 11Disease Ontology, 13DISEASES, 31ICD10 via Orphanet, 32ICD9CM, 39MeSH, 40MESH via Orphanet, 48NIH Rare Diseases, 54Orphanet, 62SNOMED-CT, 68UMLS, 69UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Tularemia:

Name: Tularemia 11 48 54 2 39 13 68
Francisella Tularensis Infection 48
Pahvant Valley Plague 48
Deerfly Fever 48
 
Ohara Disease 48
Lemming Fever 48
Rabbit Fever 48
Yatobyo 48

Characteristics:

Orphanet epidemiological data:

54
tularemia:
Prevalence: 1-9/1000000 (Europe),<1/1000000 (United Kingdom),<1/1000000 (Netherlands),1-9/100000 (Sweden),1-9/100000 (Czech Republic),1-9/100000 (Finland),1-9/1000000 (Austria),<1/1000000 (Belgium),<1/1000000 (Denmark),1-9/1000000 (Croatia),1-9/1000000 (Bulgaria),<1/1000000 (Estonia),<1/1000000 (France),<1/1000000 (Germany),<1/1000000 (Italy),1-9/1000000 (Latvia),<1/1000000 (Lithuania),<1/1000000 (Poland),<1/1000000 (Romania),<1/1000000 (Slovenia),1-9/1000000 (Switzerland),1-9/1000000 (Spain),1-9/100000 (Norway); Age of onset: All ages; Age of death: any age

Classifications:



External Ids:

Disease Ontology11 DOID:2123
ICD9CM32 021.8
MeSH39 D014406
Orphanet54 ORPHA3392
ICD10 via Orphanet31 A21.0, A21.1, A21.2 A21.3, A21.7, A21.8, A21.9, more
MESH via Orphanet40 D014406
UMLS via Orphanet69 C0041351

Summaries for Tularemia

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NIH Rare Diseases:48 Tularemia is an infection common in wild rodents caused by the bacterium francisella tularensis. it is transmitted to humans by contact with infected animal tissues or by ticks, biting flies, and mosquitoes. the condition is most common in north america and parts of europe and asia. it is very rare in the united states. the illness, which is characterized by fever, chills, headache, joint pain and muscle weakness, may continue for several weeks after symptoms begin. streptomycin and tetracycline are commonly used to treat the infection. last updated: 5/10/2010

MalaCards based summary: Tularemia, also known as francisella tularensis infection, is related to pneumonic tularemia and ulceroglandular tularemia. An important gene associated with Tularemia is PPARA (Peroxisome Proliferator Activated Receptor Alpha), and among its related pathways are Legionellosis and Nucleotide-binding Oligomerization Domain (NOD) pathway. Affiliated tissues include lymph node, testes and skin.

Disease Ontology:11 A primary bacterial infectious disease that has material basis in Francisella tularensis, which is transmitted by dog tick bite (Dermacentor variabilis), transmitted by deer flies (Chrysops sp) or transmitted by contact with infected animal tissues.

CDC:2 Tularemia is a disease of animals and humans caused by the bacterium Francisella tularensis. Rabbits, hares, and rodents are especially susceptible and often die in large numbers during outbreaks. Humans can become infected through several routes, including:

Wikipedia:71 Tularemia is a serious infectious disease caused by the intracellular bacterium Francisella tularensis.... more...

Related Diseases for Tularemia

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Graphical network of the top 20 diseases related to Tularemia:



Diseases related to tularemia

Symptoms & Phenotypes for Tularemia

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Drugs & Therapeutics for Tularemia

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Drugs for Tularemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1VaccinesPhase 26611

Interventional clinical trials:

idNameStatusNCT IDPhase
1Phase II Tularemia Vaccine ComparisonCompletedNCT01150695Phase 2
2Safety and Immunogenicity Study of a Live Francisella Tularensis VaccineCompletedNCT00584844Phase 2
3Continued Safety and Immunogenicity Study of a Live Francisella Tularensis VaccineEnrolling by invitationNCT00787826Phase 2

Search NIH Clinical Center for Tularemia


Cochrane evidence based reviews: tularemia

Genetic Tests for Tularemia

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Anatomical Context for Tularemia

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MalaCards organs/tissues related to Tularemia:

36
Lymph node, Testes, Skin, T cells, Myeloid, Whole blood, Liver

Publications for Tularemia

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Articles related to Tularemia:

(show top 50)    (show all 590)
idTitleAuthorsYear
1
High-risk regions and outbreak modelling of tularemia in humans. (27806741)
2017
2
The Natural History of Pneumonic Tularemia in Female Fischer 344 Rats after Inhalational Exposure to Aerosolized Francisella tularensis Subspecies tularensis Strain SCHU S4. (27939130)
2017
3
Tularemia vaccine development: paralysis or progress? (27200274)
2016
4
Rabbit hunter uveitis: case report of tularemia uveitis. (27585457)
2016
5
An Immature Myeloid/Myeloid-Suppressor Cell Response Associated with Necrotizing Inflammation Mediates Lethal Pulmonary Tularemia. (27015566)
2016
6
Towards development of improved serodiagnostics for tularemia using Francisella tularensis proteome microarrays. (27098957)
2016
7
MBL, P2X7, and SLC11A1 gene polymorphisms in patients with oropharyngeal tularemia. (27223255)
2016
8
Introduction and persistence of tularemia in Bulgaria. (27790972)
2016
9
Ultrasonography and contrast-enhanced CT findings of tularemia in the neck. (27498683)
2016
10
Intracellular Delivery: Redox-Triggered Release of Moxifloxacin from Mesoporous Silica Nanoparticles Functionalized with Disulfide Snap-Tops Enhances Efficacy Against Pneumonic Tularemia in Mice (Small 27/2016). (27412305)
2016
11
Respiratory and oral vaccination improves protection conferred by the live vaccine strain against pneumonic tularemia in the rabbit model. (27511964)
2016
12
Phylogeography of Francisella tularensis from Tibet, China: Evidence for an asian origin and radiation of holarctica-type Tularemia. (27150591)
2016
13
Vaccination evokes gender-dependent protection against tularemia infection in C57BL/6Tac mice. (27182819)
2016
14
Respiratory Tularemia: Francisella Tularensis and Microarray Probe Designing. (28077973)
2016
15
Ulceroglandular Tularemia Following Contact with a Boar. (26658527)
2016
16
Inflammasome-Independent NLRP3 Restriction of a Protective Early Neutrophil Response to Pulmonary Tularemia. (27926940)
2016
17
Predicting tularemia with clinical, laboratory and demographical findings in the ED. (26577431)
2016
18
Tularemia. (28088821)
2016
19
Tularemia vaccines. (27194547)
2016
20
Lipoxin A4, a 5-lipoxygenase pathway metabolite, modulates immune response during acute respiratory tularemia. (27630217)
2016
21
Cluster of ulceroglandular tularemia cases in Slovenia. (27496749)
2016
22
The prevalence of tularemia in occupational groups that have contact with animals. (27511510)
2016
23
Redox-Triggered Release of Moxifloxacin from Mesoporous Silica Nanoparticles Functionalized with Disulfide Snap-Tops Enhances Efficacy Against Pneumonic Tularemia in Mice. (27246117)
2016
24
Ecology of Tularemia in Central US Endemic Region. (27525215)
2016
25
First Pediatric Case of Tularemia after a Coyote Bite. (26885419)
2016
26
Spatio-temporal dynamics of tularemia in French wildlife: 2002-2013. (27435644)
2016
27
A Bioluminescent Francisella tularensis SCHU S4 Strain Enables Noninvasive Tracking of Bacterial Dissemination and the Evaluation of Antibiotics in an Inhalational Mouse Model of Tularemia. (27671061)
2016
28
ECO-EPIZOOTIOLOGIC STUDY OF FRANCISELLA TULARENSIS, THE AGENT OF TULAREMIA, IN QUA8BEC WILDLIFE. (26967133)
2016
29
Tularemia Masquerading as Ecthyma. (27562918)
2016
30
Francisella tularensis: No Evidence for Transovarial Transmission in the Tularemia Tick Vectors Dermacentor reticulatus and Ixodes ricinus. (26244842)
2015
31
Oropharyngeal Tularemia Outbreak Associated with Drinking Contaminated Tap Water, Turkey, July-September 2013. (26584074)
2015
32
Epidemiology and ecology of tularemia in Sweden, 1984-2012. (25529978)
2015
33
Tularemia among free-ranging mice without infection of exposed humans, Switzerland, 2012. (25531919)
2015
34
Epidemiological and clinical characteristics and management of oropharyngeal tularemia outbreak. (26422865)
2015
35
Comparison of experimental respiratory tularemia in three nonhuman primate species. (25766142)
2015
36
About three cases of ulceroglandular tularemia, is this the re-emergence of F. tularensis in Belgium? (25847026)
2015
37
Development of a Multivalent Subunit Vaccine against Tularemia Using Tobacco Mosaic Virus (TMV) Based Delivery System. (26098553)
2015
38
Francisella tularensis LVS surface and membrane proteins as targets of effective post-exposure immunization for tularemia. (25494920)
2015
39
Dynamics of a Tularemia Outbreak in a Closely Monitored Free-Roaming Population of Wild House Mice. (26536232)
2015
40
The first pediatric case of tularemia in Korea: manifested with pneumonia and possible infective endocarditis. (26576185)
2015
41
Alarmin function of galectin-9 in murine respiratory tularemia. (25898318)
2015
42
Diverse Francisella tularensis strains and oropharyngeal tularemia, Turkey. (25531237)
2015
43
Environmental Monitoring and Surveillance of Rodents and Vectors for Francisella tularensis Following Outbreaks of Human Tularemia in Georgia. (26394283)
2015
44
Successful protection against tularemia in C57BL/6 mice is correlated with expansion of Francisella tularensis-specific effector T cells. (25410207)
2015
45
Prospective investigation of the hypothalamo-pituitary-adrenal axis in patients with tularemia. (26281320)
2015
46
Pulmonary tularemia. (26183889)
2015
47
Zoonotic occupational diseases in forestry workers - Lyme borreliosis, tularemia and leptospirosis in Europe. (25780827)
2015
48
Preclinical Testing of a Vaccine Candidate against Tularemia. (25897786)
2015
49
Development and evaluation of a latex agglutination test for the rapid serodiagnosis of tularemia. (25727796)
2015
50
Tularemia, a re-emerging infectious disease in Iran and neighboring countries. (25773439)
2015

Variations for Tularemia

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Expression for genes affiliated with Tularemia

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Search GEO for disease gene expression data for Tularemia.

Pathways for genes affiliated with Tularemia

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Pathways related to Tularemia according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.8CASP1, TLR2
29.8AIM2, CASP1

GO Terms for genes affiliated with Tularemia

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Cellular components related to Tularemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1AIM2 inflammasome complexGO:00971699.8AIM2, CASP1

Biological processes related to Tularemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of interleukin-1 beta secretionGO:005071810.3AIM2, CASP1
2pyroptosisGO:007026910.3AIM2, CASP1
3response to hypoxiaGO:00016669.6CASP1, PPARA, TLR2

Sources for Tularemia

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet