MCID: TWN005
MIFTS: 15

Twenty-Nail Dystrophy malady

Rare diseases category

Aliases & Classifications for Twenty-Nail Dystrophy

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Aliases & Descriptions for Twenty-Nail Dystrophy:

Name: Twenty-Nail Dystrophy 45
Onychodystrophy Totalis, Isolated 45
 
Twenty Nail Dystrophy 65


Classifications:



Summaries for Twenty-Nail Dystrophy

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NIH Rare Diseases:45 Twenty-nail dystrophy is a condition that affects the nails of the fingers and toes.  the surface of all twenty nails develop ridges, splitting, and roughening (similar to sandpaper).  the nails may also be dull and brittle. this condition most commonly occurs in childhood, but it can occur at any age.  the exact cause is unknown; but in some cases, it appears to be associated with other skin conditions such as lichen planus, eczema, psoriasis and alopecia areata. many cases of twenty-nail dystrophy that begin gradually in early childhood tend to disappear naturally as the child ages. last updated: 7/4/2012

MalaCards based summary: Twenty-Nail Dystrophy, also known as onychodystrophy totalis, isolated, is related to lichen planus and alopecia. An important gene associated with Twenty-Nail Dystrophy is FZD6 (Frizzled Class Receptor 6). Affiliated tissues include skin.

Related Diseases for Twenty-Nail Dystrophy

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Diseases related to Twenty-Nail Dystrophy via text searches within MalaCards or GeneCards Suite gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1lichen planus10.6
2alopecia10.5
3ichthyosis vulgaris10.4
4alopecia universalis10.4
5alopecia areata10.4
6ichthyosis10.4
7incontinentia pigmenti10.2
8pachyonychia congenita10.2
9autosomal dominant nail dysplasia10.2

Graphical network of diseases related to Twenty-Nail Dystrophy:



Diseases related to twenty-nail dystrophy

Symptoms for Twenty-Nail Dystrophy

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Drugs & Therapeutics for Twenty-Nail Dystrophy

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Twenty-Nail Dystrophy

Genetic Tests for Twenty-Nail Dystrophy

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Anatomical Context for Twenty-Nail Dystrophy

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MalaCards organs/tissues related to Twenty-Nail Dystrophy:

33
Skin

Animal Models for Twenty-Nail Dystrophy or affiliated genes

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Publications for Twenty-Nail Dystrophy

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Articles related to Twenty-Nail Dystrophy:

(show all 39)
idTitleAuthorsYear
1
Recessive mutations in the gene encoding frizzled 6 cause twenty nail dystrophy--expanding the differential diagnosis for pachyonychia congenita. (23374899)
2013
2
Twenty nail dystrophy in association with zosteriform lichen planus. (22837581)
2012
3
Clinical study of twenty-nail dystrophy in Korea. (21913910)
2012
4
Alopecia universalis with twenty-nail dystrophy (trachyonychia). (18627760)
2008
5
Segmental vitiligo and twenty-nail dystrophy: an unusual association. (19172003)
2008
6
Twenty nail dystrophy trachyonychia: an overview. (17535400)
2007
7
Twenty nail dystrophy in vitiligo. (17291300)
2007
8
Twenty-nail dystrophy originating from lichen planus. (15654171)
2005
9
Twenty-nail dystrophy (trachyonychia) caused by lichen planus in a patient with gold allergy. (15888190)
2005
10
Twenty-nail dystrophy in a girl with incontinentia pigmenti. (12581087)
2003
11
Twenty-nail dystrophy in a mother and her 7-year-old daughter associated with balanced translocation 46, XX, t(6q13;10p13). (12072794)
2002
12
An association of twenty-nail dystrophy with vitiligo. (11280463)
2001
13
Twenty-nail dystrophy and vitiligo: a rare association. (10071326)
1999
14
A case report of twenty-nail dystrophy. (9046745)
1997
15
Twenty-nail dystrophy (trachyonychia) caused by lichen planus in a patient with alopecia universalis and ichthyosis vulgaris. (7593807)
1995
16
Idiopathic trachyonychia (twenty-nail dystrophy): a pathological study of 23 patients. (7857841)
1994
17
Twenty-nail dystrophy due to lichen planus in a patient with alopecia areata. (8348737)
1993
18
Twenty-nail dystrophy associated with hematologic abnormalities. (1755311)
1991
19
Twenty-nail dystrophy of childhood with koilonychia. (2007303)
1991
20
Twenty-nail dystrophy treated with topical PUVA. (1981426)
1990
21
Twenty-nail dystrophy. A clinical manifestation of spongiotic inflammation of the nail matrix. (2383032)
1990
22
Twenty nail dystrophy in identical twins. (3412992)
1988
23
Twenty-nail dystrophy of childhood: a misnamed syndrome. (3608573)
1987
24
Twenty-nail dystrophy of childhood: a reappraisal. (3881224)
1985
25
Twenty-nail dystrophy of childhood--two cases in one family. (6499277)
1984
26
Twenty-nail dystrophy: a hypothesis. (6703749)
1984
27
Twenty-nail dystrophy: report of a case and review of the literature. (6203314)
1984
28
Twenty-nail dystrophy of childhood: a sign of localized lichen planus. (6494064)
1984
29
IgA in twenty-nail dystrophy. (6886924)
1983
30
Familial severe twenty-nail dystrophy. (7130495)
1982
31
Hereditary twenty-nail dystrophy in a Sicilian family. (7143386)
1982
32
Twenty-nail dystrophy (trachyonychia) associated with selective IgA deficiency. (7062176)
1982
33
Twenty-nail dystrophy and ichthyosis vulgaris. (7247418)
1981
34
Twenty-nail dystrophy of alopecia areata. (7377792)
1980
35
Twenty-nail dystrophy of childhood. Case report and histopathological findings. (427021)
1979
36
Twenty-nail dystrophy. (434859)
1979
37
Twenty-nail dystrophy: a variant of lichen planus. (646381)
1978
38
Twenty-nail dystrophy of childhood. (831628)
1977
39
Twenty-nail dystrophy. (911187)
1977

Variations for Twenty-Nail Dystrophy

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Expression for genes affiliated with Twenty-Nail Dystrophy

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Search GEO for disease gene expression data for Twenty-Nail Dystrophy.

Pathways for genes affiliated with Twenty-Nail Dystrophy

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GO Terms for genes affiliated with Twenty-Nail Dystrophy

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Sources for Twenty-Nail Dystrophy

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet