MCID: TWN005
MIFTS: 17

Twenty-Nail Dystrophy malady

Rare diseases, Skin diseases categories

Summaries for Twenty-Nail Dystrophy

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NIH Rare Diseases:41 Twenty-nail dystrophy is a condition that affects the nails of the fingers and toes.  the surface of all twenty nails develop ridges, splitting, and roughening (similar to sandpaper).  the nails may also be dull and brittle. this condition most commonly occurs in childhood, but it can occur at any age.  the exact cause is unknown; but in some cases, it appears to be associated with other skin conditions such as lichen planus, eczema, psoriasis and alopecia areata. many cases of twenty-nail dystrophy that begin gradually in early childhood tend to disappear naturally as the child ages. last updated: 7/4/2012

MalaCards based summary: Twenty-Nail Dystrophy, also known as autosomal dominant nail dysplasia, is related to lichen planus and alopecia. Affiliated tissues include skin.

Aliases & Classifications for Twenty-Nail Dystrophy

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Sources:
41NIH Rare Diseases, 47Orphanet, 60UMLS, 26ICD10 via Orphanet
See all sources

Twenty-Nail Dystrophy, Aliases & Descriptions:

Name: Twenty-Nail Dystrophy 41 47
Autosomal Dominant Nail Dysplasia 41 47
Onychodystrophy Totalis 41 47
 
Onychodystrophy Totalis, Isolated 41
Twenty Nail Dystrophy 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Skin diseases
Orphanet: 47 
Rare skin diseases


Characteristics (Orphanet epidemiological data):

47
autosomal dominant nail dysplasia:
Inheritance: Autosomal dominant; Age of onset: Childhood; Age of death: normal life expectancy


External Ids:

Orphanet47 79153
ICD10 via Orphanet26 L60.3

Related Diseases for Twenty-Nail Dystrophy

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Diseases related to Twenty-Nail Dystrophy via text searches within MalaCards or GeneCards Suite gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1lichen planus10.6
2alopecia10.5
3ichthyosis vulgaris10.4
4alopecia universalis10.4
5alopecia areata10.4
6pachyonychia congenita10.2

Graphical network of diseases related to Twenty-Nail Dystrophy:



Diseases related to twenty-nail dystrophy

Symptoms for Twenty-Nail Dystrophy

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Drugs & Therapeutics for Twenty-Nail Dystrophy

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Drug clinical trials:

Search ClinicalTrials for Twenty-Nail Dystrophy

Search NIH Clinical Center for Twenty-Nail Dystrophy

Genetic Tests for Twenty-Nail Dystrophy

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Anatomical Context for Twenty-Nail Dystrophy

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MalaCards organs/tissues related to Twenty-Nail Dystrophy:

31
Skin

Animal Models for Twenty-Nail Dystrophy or affiliated genes

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Publications for Twenty-Nail Dystrophy

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Articles related to Twenty-Nail Dystrophy:

(show all 40)
idTitleAuthorsYear
1
Recessive mutations in the gene encoding frizzled 6 cause twenty nail dystrophy--expanding the differential diagnosis for pachyonychia congenita. (23374899)
2013
2
Twenty nail dystrophy in association with zosteriform lichen planus. (22837581)
2012
3
Clinical study of twenty-nail dystrophy in Korea. (21913910)
2012
4
Alopecia universalis with twenty-nail dystrophy (trachyonychia). (18627760)
2008
5
Segmental vitiligo and twenty-nail dystrophy: an unusual association. (19172003)
2008
6
Twenty nail dystrophy trachyonychia: an overview. (17535400)
2007
7
Twenty nail dystrophy in vitiligo. (17291300)
2007
8
Twenty-nail dystrophy originating from lichen planus. (15654171)
2005
9
Twenty-nail dystrophy (trachyonychia) caused by lichen planus in a patient with gold allergy. (15888190)
2005
10
Twenty-nail dystrophy in a girl with incontinentia pigmenti. (12581087)
2003
11
Twenty-nail dystrophy in a mother and her 7-year-old daughter associated with balanced translocation 46, XX, t(6q13;10p13). (12072794)
2002
12
An association of twenty-nail dystrophy with vitiligo. (11280463)
2001
13
Twenty-nail dystrophy and vitiligo: a rare association. (10071326)
1999
14
Twenty-nail dystrophy in monozygotic twins. (10343962)
1999
15
A case report of twenty-nail dystrophy. (9046745)
1997
16
Twenty-nail dystrophy (trachyonychia) caused by lichen planus in a patient with alopecia universalis and ichthyosis vulgaris. (7593807)
1995
17
Idiopathic trachyonychia (twenty-nail dystrophy): a pathological study of 23 patients. (7857841)
1994
18
Twenty-nail dystrophy due to lichen planus in a patient with alopecia areata. (8348737)
1993
19
Twenty-nail dystrophy associated with hematologic abnormalities. (1755311)
1991
20
Twenty-nail dystrophy of childhood with koilonychia. (2007303)
1991
21
Twenty-nail dystrophy treated with topical PUVA. (1981426)
1990
22
Twenty-nail dystrophy. A clinical manifestation of spongiotic inflammation of the nail matrix. (2383032)
1990
23
Twenty nail dystrophy in identical twins. (3412992)
1988
24
Twenty-nail dystrophy of childhood: a misnamed syndrome. (3608573)
1987
25
Twenty-nail dystrophy of childhood: a reappraisal. (3881224)
1985
26
Twenty-nail dystrophy of childhood--two cases in one family. (6499277)
1984
27
Twenty-nail dystrophy: a hypothesis. (6703749)
1984
28
Twenty-nail dystrophy: report of a case and review of the literature. (6203314)
1984
29
Twenty-nail dystrophy of childhood: a sign of localized lichen planus. (6494064)
1984
30
IgA in twenty-nail dystrophy. (6886924)
1983
31
Familial severe twenty-nail dystrophy. (7130495)
1982
32
Hereditary twenty-nail dystrophy in a Sicilian family. (7143386)
1982
33
Twenty-nail dystrophy (trachyonychia) associated with selective IgA deficiency. (7062176)
1982
34
Twenty-nail dystrophy and ichthyosis vulgaris. (7247418)
1981
35
Twenty-nail dystrophy of alopecia areata. (7377792)
1980
36
Twenty-nail dystrophy of childhood. Case report and histopathological findings. (427021)
1979
37
Twenty-nail dystrophy. (434859)
1979
38
Twenty-nail dystrophy: a variant of lichen planus. (646381)
1978
39
Twenty-nail dystrophy of childhood. (831628)
1977
40
Twenty-nail dystrophy. (911187)
1977

Variations for Twenty-Nail Dystrophy

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Expression for genes affiliated with Twenty-Nail Dystrophy

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Search GEO for disease gene expression data for Twenty-Nail Dystrophy.

Pathways for genes affiliated with Twenty-Nail Dystrophy

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Compounds for genes affiliated with Twenty-Nail Dystrophy

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GO Terms for genes affiliated with Twenty-Nail Dystrophy

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Products for genes affiliated with Twenty-Nail Dystrophy

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Sources for Twenty-Nail Dystrophy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet