MCID: TWN001
MIFTS: 39

Twin-to-Twin Transfusion Syndrome malady

Blood category

Summaries for Twin-to-Twin Transfusion Syndrome

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Twin-to-twin transfusion syndrome (TTTS, also known as Feto-Fetal Transfusion Syndrome (FFTS) and Twin... more...

MalaCards: Twin-to-Twin Transfusion Syndrome, also known as fetal blood loss from fetal hemorrhage into co-twin, is related to polyhydramnios and twin twin transfusion syndrome. An important gene associated with Twin-to-Twin Transfusion Syndrome is ASPRV1 (aspartic peptidase, retroviral-like 1), and among its related pathways are Rheumatoid arthritis and Pathways in cancer. The compounds mannitol and toki-shakuyaku-san have been mentioned in the context of this disorder. Affiliated tissues include placenta, and related mouse phenotypes are renal/urinary system and embryogenesis.

Aliases & Classifications for Twin-to-Twin Transfusion Syndrome

Sources:
8Disease Ontology, 10DISEASES, 49Orphanet, 61UMLS, 57SNOMED-CT, 35MeSH, 26ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Blood


Aliases & Descriptions:

twin-to-twin transfusion syndrome 8 10
fetal blood loss from fetal hemorrhage into co-twin 8
ffts - fetofetal transfusion syndrome 61
twin to twin transfusion syndrome 49
feto-fetal transfusion syndrome 49
fetal hemorrhage into co-twin 8
twin-to-twin blood transfer 8
twin to twin transfusion 8


External Ids:

Disease Ontology8 DOID:13576
MeSH35 D005330
ICD10 via Orphanet26 O43.0

Related Diseases for Twin-to-Twin Transfusion Syndrome

Sources:
17GeneCards, 18GeneDecks
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Diseases in the Twin-to-Twin Transfusion Syndrome family:

twin twin transfusion syndrome

Diseases related to Twin-to-Twin Transfusion Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 185)
idRelated DiseaseScoreTop Affiliating Genes
1polyhydramnios30.8AFP
2twin twin transfusion syndrome11.5
3n syndrome11.0
4short syndrome10.4
5arteriovenous malformation10.3
6adult syndrome10.3
7char syndrome10.3
8amniotic band syndrome10.3
9tricuspid atresia10.3
10congenital cytomegalovirus10.3
11hydrops fetalis10.3
12cytomegalovirus infection10.3
13gingivitis10.0CST3
14hepatitis10.0AFP
15hypothyroidism10.0CST3
16cerebrovascular disease10.0CST3
17amyotrophic lateral sclerosis10.0CST3
18oligohydramnios10.0AFP
19vesicoureteral reflux10.0AMBP
20multiple myeloma10.0B2M
21gastroschisis10.0AFP
22galactosemia10.0ALB
23portal vein thrombosis10.0AFP
24vasculitis10.0ALB
25glaucoma10.0EDN1
26congenital heart defect10.0NPPA
27pancreatitis10.0ALB
28viral hepatitis10.0AFP
29neuropathy10.0ALB
30meningitis10.0ALB
31hepatitis e10.0AMBP
32kidney cancer10.0VEGFA
33pulmonary fibrosis10.0EDN1
34crohn's disease10.0ALB
35brain edema10.0ALB
36blindness10.0VEGFA
37lupus nephritis10.0ALB
38cholestasis10.0ALB
39hyperparathyroidism10.0ALB
40hypoaldosteronism10.0REN
41rhinitis10.0ALB
42poems syndrome10.0VEGFA
43chondrosarcoma10.0AMBP
44varicose veins10.0ALB
45pulmonary embolism10.0ALB
46macroglobulinemia10.0B2M
47portal hypertension10.0EDN1, REN
48thrombocytopenia10.0ALB
49laryngeal carcinoma10.0VEGFC
50alzheimer's disease10.0CST3, AMBP

Graphical network of the top 20 diseases related to Twin-to-Twin Transfusion Syndrome:



Diseases related to twin-to-twin transfusion syndrome

Clinical Features for Twin-to-Twin Transfusion Syndrome

Drugs & Therapeutics for Twin-to-Twin Transfusion Syndrome

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Twin-to-Twin Transfusion Syndrome

Drug clinical trials:

Search ClinicalTrials for Twin-to-Twin Transfusion Syndrome

Search NIH Clinical Center for Twin-to-Twin Transfusion Syndrome

Search CenterWatch for Twin-to-Twin Transfusion Syndrome

Genetic Tests for Twin-to-Twin Transfusion Syndrome

Anatomical Context for Twin-to-Twin Transfusion Syndrome

Sources:
33MalaCards
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MalaCards organs/tissues related to Twin-to-Twin Transfusion Syndrome:

33
Placenta

Animal Models for Twin-to-Twin Transfusion Syndrome or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Twin-to-Twin Transfusion Syndrome:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053679.2EDN1, ANGPT1, HIF1A, REN
2MP:00053809.1AMBP, EDN1, PGF
3MP:00053698.7CST3, NPPA, FLT1, ANGPT1, HIF1A, REN
4MP:00053768.7CST3, NPPA, B2M, AFP, REN, PGF
5MP:00053818.6ALB, HIF1A, ANGPT2, VEGFA, B2M, EDN1
6MP:00020068.3CST3, B2M, AFP, VEGFA, HIF1A, PGF
7MP:00028737.6EDN1, FLT1, VEGFA, HIF1A, REN, ALB
8MP:00107687.0EDN1, FLT1, B2M, AFP, VEGFA, VEGFC
9MP:00053856.9ADD3, CST3, NPPA, EDN1, FLT1, B2M

Publications for Twin-to-Twin Transfusion Syndrome

Genetic Variations for Twin-to-Twin Transfusion Syndrome

Expression for genes affiliated with Twin-to-Twin Transfusion Syndrome

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Twin-to-Twin Transfusion Syndrome

Search GEO for disease gene expression data for Twin-to-Twin Transfusion Syndrome.

Pathways for genes affiliated with Twin-to-Twin Transfusion Syndrome

Sources:
30KEGG, 54Reactome, 52QIAGEN, 12EMD Millipore, 38NCBI BioSystems Database, 50PharmGKB, 56SinoBiological, 4Cell Signaling Technology
See all sources

Pathways related to Twin-to-Twin Transfusion Syndrome according to GeneCards/GeneDecks:

(show all 23)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1ANGPT1
210.0HIF1A
3
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9.8CST3, NPPA, B2M
4
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9.7PGF, REN
5
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9.5ALB, VEGFC, VEGFA
6
Development Leptin signaling via JAK/STAT and MAPK cascades
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9.5EDN1, VEGFA, HIF1A
79.5HIF1A, VEGFA, EDN1
89.4HIF1A, VEGFC, EDN1
9
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9.1VEGFA, VEGFC, ANGPT1, ANGPT2
10
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9.0FLT1, VEGFC, ANGPT1, ANGPT2
118.9FLT1, VEGFA, ANGPT1, HIF1A
12
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8.9PGF, VEGFC, VEGFA, FLT1
13
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8.9PGF, VEGFC, VEGFA, FLT1
14
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8.9FLT1, VEGFA, VEGFC, PGF
15
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8.9FLT1, VEGFA, VEGFC, PGF
168.7REN, HIF1A, ANGPT2, VEGFC, FLT1
17
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8.5FLT1, VEGFC, ANGPT1, ANGPT2, PGF
18
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8.5FLT1, VEGFC, ANGPT1, ANGPT2, PGF
19
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8.5FLT1, VEGFC, ANGPT1, ANGPT2, PGF
20
Hide members
8.4FLT1, VEGFA, VEGFC, HIF1A, PGF
218.2FLT1, VEGFA, VEGFC, ANGPT1, ANGPT2, PGF
228.1HIF1A, NPPA, EDN1, FLT1, VEGFA, ANGPT1
23
Hide members
8.0FLT1, VEGFC, ANGPT1, ANGPT2, HIF1A, PGF

Compounds for genes affiliated with Twin-to-Twin Transfusion Syndrome

Sources:
45Novoseek, 11DrugBank, 24HMDB, 50PharmGKB, 29IUPHAR, 60Tocris Bioscience
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Compounds related to Twin-to-Twin Transfusion Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 151)
idCompoundScoreTop Affiliating Genes
1mannitol45 1111.4ALB
2toki-shakuyaku-san4510.1EDN1, NPPA, REN
3uric acid45 2411.1CST3, AFP, B2M
4pge24510.0REN, VEGFC, VEGFA
5p-aminohippuric acid4510.0NPPA, ALB, B2M
6ramipril45 1110.9CST3, REN, ALB, NPPA
7urodilatin459.9EDN1, NPPA, REN
8lisinopril45 11 2411.8REN, ALB, NPPA, VEGFA
9perindopril45 50 1111.8VEGFA, ALB, NPPA, REN
10omapatrilat459.8REN, EDN1, NPPA
11carvedilol45 50 29 1112.7VEGFA, EDN1, NPPA, REN
1251-cr-edta459.7ALB, CST3, NPPA, B2M, REN
13sodium45 2410.7AMBP, AFP, REN, EDN1
14cilazapril45 1110.7EDN1, REN, NPPA
15iohexol459.6CST3, B2M, ALB, AMBP
16candesartan45 29 1111.5HIF1A, REN, ALB, VEGFA
17ang ii459.5NPPA, VEGFA, EDN1, REN
18potassium45 11 2411.5REN, ANGPT1, AFP, AMBP
19digoxin45 50 60 11 2413.5NPPA, HIF1A, CST3, REN
20trandolapril45 1110.5NPPA, REN, EDN1
21nitroglycerin45 1110.4EDN1, B2M, NPPA, REN, HIF1A
22captopril45 29 50 60 1113.4REN, B2M, ALB, CST3, EDN1, NPPA
23hanp459.4EDN1, NPPA, AMBP, B2M, REN
24kininogen459.4ALB, REN, NPPA, AMBP, CST3
25enalapril45 50 1111.4AMBP, NPPA, EDN1, REN, ALB
26sodium nitroprusside459.3NPPA, EDN1, B2M, HIF1A, REN
27celecoxib45 60 29 50 11 2414.3ALB, REN, HIF1A, ANGPT2, VEGFA
28urea45 11 2411.2AMBP, AFP, B2M, CST3, ALB
29inulin459.2AMBP, CST3, NPPA, B2M, REN, ALB
30nifedipine45 50 29 1112.2EDN1, B2M, AMBP, REN, NPPA
31matrigel459.1FLT1, HIF1A, ANGPT1, PGF
32sunitinib45 50 1111.1PGF, HIF1A, VEGFA, FLT1
33fibrinogen458.7AMBP, AFP, ANGPT1, ANGPT2, ALB, CST3
34glyceraldehyde 3-phosphate458.7B2M, FLT1, HIF1A, ANGPT2, ANGPT1, VEGFC
35oxygen45 249.7ANGPT2, ANGPT1, VEGFC, AFP, PGF, FLT1
36prostacyclin458.6VEGFA, ANGPT1, FLT1, EDN1, NPPA, PGF
37cyclosporin a45 29 6010.5ANGPT2, EDN1, B2M, ANGPT1, HIF1A, AMBP
38heparin45 29 11 2411.5AFP, VEGFA, PGF, FLT1, PAPPA
39doxorubicin45 50 1110.4HIF1A, FLT1, ANGPT1, AFP, VEGFA, B2M
40cisplatin45 50 60 1111.4HIF1A, CST3, B2M, AFP, VEGFA, AMBP
41thymidine45 249.2VEGFC, HIF1A, FLT1, EDN1, ANGPT2, B2M
42dexamethasone45 50 29 1111.1HIF1A, PAPPA, REN, AFP, VEGFA, VEGFC
43steroid457.8B2M, REN, ANGPT1, AMBP, AFP, ANGPT2
44nitric oxide45 11 249.7EDN1, HIF1A, FLT1, ANGPT1, ANGPT2, REN
45paraffin457.7FLT1, AFP, B2M, HIF1A, VEGFA, VEGFC
46creatinine457.7AMBP, CST3, NPPA, FLT1, AFP, ANGPT2
47lipid457.0ALB, AMBP, CST3, AFP, VEGFC, PGF
48glucose456.7FLT1, AMBP, PAPPA, PGF, REN, CST3
49vegf455.9PAPPA, FLT1, AFP, EDN1, NPPA, CST3
50calcium45 50 11 248.9CST3, AMBP, NPPA, B2M, VEGFC, EDN1

GO Terms for genes affiliated with Twin-to-Twin Transfusion Syndrome

Sources:
16Gene Ontology
See all sources

Cellular components related to Twin-to-Twin Transfusion Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.5ALB, VEGFC, VEGFA
2extracellular regionGO:0055765.5AMBP, CST3, NPPA, EDN1, B2M, VEGFA
3extracellular spaceGO:0056155.0ALB, AMBP, CST3, NPPA, EDN1, FLT1

Biological processes related to Twin-to-Twin Transfusion Syndrome according to GeneCards/GeneDecks:

(show all 27)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of chemokine-mediated signaling pathwayGO:07010110.1EDN1, HIF1A
2glomerulus vasculature developmentGO:07201210.1ANGPT1, ANGPT2
3positive regulation of mast cell chemotaxisGO:06075410.1VEGFC, VEGFA
4Tie signaling pathwayGO:04801410.1ANGPT1, ANGPT2
5positive regulation of transcription from RNA polymerase II promoter in response to hypoxiaGO:06141910.0VEGFA, HIF1A
6positive regulation of endothelial cell migrationGO:0105959.9ANGPT1, VEGFA, EDN1
7positive regulation of receptor biosynthetic processGO:0108709.8HIF1A, EDN1
8induction of positive chemotaxisGO:0509309.8VEGFC, VEGFA
9patterning of blood vesselsGO:0015699.8EDN1, FLT1, VEGFA
10positive regulation of blood vessel endothelial cell migrationGO:0435369.8VEGFA, VEGFC, ANGPT1
11positive chemotaxisGO:0509189.8ANGPT1, VEGFC, VEGFA
12positive regulation of MAP kinase activityGO:0434069.8VEGFA, FLT1, EDN1
13positive regulation of protein autophosphorylationGO:0319549.7VEGFC, VEGFA
14positive regulation of neuroblast proliferationGO:0020529.7HIF1A, VEGFC, VEGFA
15positive regulation of vascular endothelial growth factor receptor signaling pathwayGO:0309499.7HIF1A, VEGFA, FLT1
16platelet degranulationGO:0025769.5VEGFA, VEGFC, ALB
17positive regulation of cell divisionGO:0517819.5VEGFA, VEGFC, PGF
18sprouting angiogenesisGO:0020409.5FLT1, ANGPT1, PGF
19dopaminergic neuron differentiationGO:0715429.4HIF1A, VEGFA
20positive regulation of endothelial cell proliferationGO:0019389.4PGF, HIF1A, VEGFA
21vascular endothelial growth factor receptor signaling pathwayGO:0480109.3PGF, VEGFC, VEGFA, FLT1
22angiogenesisGO:0015259.2VEGFA, VEGFC, ANGPT2, HIF1A
23response to hypoxiaGO:0016669.0EDN1, VEGFA, ANGPT2, HIF1A, PGF
24blood coagulationGO:0075969.0VEGFA, VEGFC, ANGPT1, ANGPT2, ALB
25positive regulation of cell proliferationGO:0082848.8EDN1, FLT1, VEGFA, VEGFC, PGF
26positive regulation of angiogenesisGO:0457668.8FLT1, VEGFA, ANGPT2, HIF1A, PGF
27female pregnancyGO:0075658.7AMBP, NPPA, PGF, PAPPA

Products for genes affiliated with Twin-to-Twin Transfusion Syndrome

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Sources for Twin-to-Twin Transfusion Syndrome

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet