MCID: TWN001
MIFTS: 55

Twin-to-Twin Transfusion Syndrome malady

Rare diseases, Blood diseases categories

Summaries for Twin-to-Twin Transfusion Syndrome

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NIH Rare Diseases:43 Twin-to-twin transfusion syndrome is a rare condition that occurs when blood moves from one identical twin (the “donor twin”) to the other (the “recipient twin”) while in the womb. the donor twin may be born smaller, with paleness, anemia, and dehydration. the recipient twin may be born larger, with redness, too much blood, and increased blood pressure, resulting in an increased risk for heart failure. treatment may require repeated amniocentesis during pregnancy. fetal laser surgery may be done to interrupt the flow of blood from one twin to the other. after birth, treatment depends on the infant's specific symptoms. the donor twin may need a blood transfusion to treat anemia. the recipient twin may need to have the volume of body fluid reduced. this may involve an exchange transfusion. medications may be given to treat heart failure in the recipient twin. last updated: 3/5/2009

MalaCards based summary: Twin-to-Twin Transfusion Syndrome, also known as twin to twin transfusion syndrome, is related to congenital heart disease and placental insufficiency. An important gene associated with Twin-to-Twin Transfusion Syndrome is ANGPT2 (angiopoietin 2), and among its related pathways are HIF1Alpha Pathway and Angiogenesis. The compounds ibopamine and cicletanine have been mentioned in the context of this disorder. Affiliated tissues include heart, placenta and brain, and related mouse phenotypes are muscle and renal/urinary system.

Wikipedia:65 Twin-to-twin transfusion syndrome (TTTS, also known as Feto-Fetal Transfusion Syndrome (FFTS) and Twin... more...

Aliases & Classifications for Twin-to-Twin Transfusion Syndrome

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Sources:
33MalaCards, 10Disease Ontology, 43NIH Rare Diseases, 12DISEASES, 49Orphanet, 62UMLS, 35MeSH, 57SNOMED-CT, 28ICD10 via Orphanet
See all sources

Twin-to-Twin Transfusion Syndrome, Aliases & Descriptions:

Name: Twin-to-Twin Transfusion Syndrome 33 10 43 12
Twin to Twin Transfusion Syndrome 43 49
Feto-Fetal Transfusion Syndrome 43 49
Twin Twin Transfusion Syndrome 33 43
Twin to Twin Transfusion 10 62
Fetal Blood Loss from Fetal Hemorrhage into Co-Twin 10
Ffts - Fetofetal Transfusion Syndrome 62
 
Fetofetal Transfusion Syndrome 43
Fetal Haemorrhage into Co-Twin 62
Fetal Hemorrhage into Co-Twin 10
Twin-to-Twin Blood Transfer 10
Fetal Transfusion Syndrome 43
Ttts 43


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Blood diseases


External Ids:

Disease Ontology10 DOID:13576
MeSH35 D005330
Orphanet49 95431
ICD10 via Orphanet28 O43.0

Related Diseases for Twin-to-Twin Transfusion Syndrome

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Diseases related to Twin-to-Twin Transfusion Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 84)
idRelated DiseaseScoreTop Affiliating Genes
1congenital heart disease30.7NPPA, EDN1
2placental insufficiency30.7ANGPT2, PGF
3hyperaldosteronism30.5REN, NPPA
4pulmonary hypertension30.5NPPA, EDN1
5ischemia30.4EDN1, VEGFC, PGF, ANGPT2, ANGPT1
6myocardial infarction30.3REN, NPPA, ANGPT1, PAPPA, PGF, EDN1
7cerebritis10.6
8cervicitis10.6
9polyhydramnios10.5
10polycythemia10.5
11chorioamnionitis10.4
12arteriovenous fistula10.3
13cerebral palsy10.3
14limb ischemia10.3
15arteriovenous malformation10.3
16down syndrome10.3
17oligohydramnios10.3
18peritonitis10.3
19pulmonary embolism10.3
20amniotic band syndrome10.3
21congenital cytomegalovirus10.3
22hydrops fetalis10.3
23transposition of the great arteries10.3
24cytomegalovirus infection10.3
25hydranencephaly10.3
26polymicrogyria10.3
27renal tubular dysgenesis10.3
28hypoplastic left heart syndrome10.3
29neutropenia10.3
30anuria10.3
31intestinal atresia10.3
32endotheliitis10.3
33immunodeficiency, x-linked, with hyper-igm10.1
34thalassemia10.1
35pituitary tumors10.1
36hypoaldosteronism10.1REN
37congestive heart failure10.0REN
38pre-eclampsia10.0PAPPA
39pyogenic granuloma10.0ANGPT2, ANGPT1
40renovascular hypertension10.0NPPA, REN
41mody, type ii10.0PAPPA, PGF
42microvascular complications of diabetes 510.0PGF, ANGPT2
43conn's syndrome10.0NPPA, REN
44pure autonomic failure10.0NPPA, REN
45hemangioma10.0ANGPT1, ANGPT2
46acute kidney failure10.0REN, NPPA
47thyroid carcinoma, papillary10.0VEGFC, ANGPT2
48renal hypertension10.0REN, EDN1
49portal hypertension10.0REN, EDN1
50angiosarcoma10.0ANGPT1, VEGFC, ANGPT2

Graphical network of the top 20 diseases related to Twin-to-Twin Transfusion Syndrome:



Diseases related to twin-to-twin transfusion syndrome

Symptoms for Twin-to-Twin Transfusion Syndrome

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Drugs & Therapeutics for Twin-to-Twin Transfusion Syndrome

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Drug clinical trials:

Search ClinicalTrials for Twin-to-Twin Transfusion Syndrome

Search NIH Clinical Center for Twin-to-Twin Transfusion Syndrome

Genetic Tests for Twin-to-Twin Transfusion Syndrome

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Anatomical Context for Twin-to-Twin Transfusion Syndrome

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MalaCards organs/tissues related to Twin-to-Twin Transfusion Syndrome:

33
Heart, Placenta, Brain, Eye, Bone, Liver, Cervix

Animal Models for Twin-to-Twin Transfusion Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Twin-to-Twin Transfusion Syndrome:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.5NPPA, ANGPT1, REN, EDN1
2MP:00053678.2EDN1, REN, ANGPT1, NPPA
3MP:00053766.8EDN1, VEGFC, PGF, PAPPA, REN, ANGPT2
4MP:00053856.4NPPA, EDN1, VEGFC, PGF, PAPPA, REN

Publications for Twin-to-Twin Transfusion Syndrome

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Articles related to Twin-to-Twin Transfusion Syndrome:

(show top 50)    (show all 250)
idTitleAuthorsYear
1
Congenital heart disease in monochorionic twins with and without twin-to-twin transfusion syndrome. (24827120)
2014
2
Diagnosis of twin-to-twin transfusion syndrome, selective fetal growth restriction, twin anaemia-polycythaemia sequence, and twin reversed arterial perfusion sequence. (24433823)
2014
3
Iatrogenic perforation of intertwin membrane after laser surgery for twin-to-twin transfusion syndrome. (24961923)
2014
4
Predictive value of cardiovascular parameters in stages 1 and 2 of twin-to-twin transfusion syndrome. (24760447)
2014
5
Hirschsprung's disease in twin to twin transfusion syndrome: a case report. (25516683)
2014
6
Twin-to-twin transfusion syndrome: knowing our boundaries. (24613025)
2014
7
Fetoscopic laser coagulation of the vascular equator versus selective coagulation for twin-to-twin transfusion syndrome: an open-label randomised controlled trial. (24613024)
2014
8
Maternal Perception of Decreased Fetal Movement in One Twin: A Clue Leading to the Early Detection of Absent Variability due to Acute Twin-to-Twin Transfusion Syndrome. (23984131)
2013
9
Preoperative prediction of the individualized risk of early fetal death after laser therapy in twin-to-twin transfusion syndrome. (23813911)
2013
10
Twin-to-twin transfusion syndrome: a case study. (23360857)
2013
11
Neonatal urinary ascites complicated by ileal perforation in a recipient of twin-to-twin transfusion syndrome. (23255026)
2013
12
Fetal and maternal complications after selective fetoscopic laser surgery for twin-to-twin transfusion syndrome: a single-center experience. (22456330)
2012
13
Evaluation of the measurement of the middle cerebral artery peak systolic velocity before and after placental laser coagulation in twin-to-twin transfusion syndrome. (22418955)
2012
14
Evaluation of cardiac performance by abdominal fetal ECG in twin-to-twin transfusion syndrome. (22886606)
2012
15
Arabin cervical pessary to prevent preterm birth in severe twin-to-twin transfusion syndrome treated by laser surgery. (23055333)
2012
16
Sonography-based Automated Volume Count to estimate fetal urine production in twin-to-twin transfusion syndrome: comparison with Virtual Organ Computer-aided AnaLysis. (21906713)
2011
17
Laser therapy for twin-to-twin transfusion syndrome causing amniotic band syndrome. (21037281)
2011
18
Laser ablation of placental vessels in twin-to-twin transfusion syndrome: a paradigm for endoscopic fetal surgery. (21854207)
2011
19
Laser therapy for twin-to-twin transfusion syndrome (TTTS). (21660997)
2011
20
The Fetal Heart in Twin-to-Twin Transfusion Syndrome. (20811613)
2010
21
Prospective assessment of fetal cardiac function with speckle tracking in healthy fetuses and recipient fetuses of twin-to-twin transfusion syndrome. (20138468)
2010
22
Management of Stage I twin-to-twin transfusion syndrome: an international survey. (20104530)
2010
23
Amniotic fluid markers of fetal cardiac dysfunction in twin-to-twin transfusion syndrome. (19801144)
2010
24
Preoperative predictors of death in twin-to-twin transfusion syndrome treated with laser ablation of placental anastomoses. (20691964)
2010
25
Survival after laser surgery for twin-to-twin transfusion syndrome: when are they out of the woods? (19159719)
2009
26
Extreme polycythemia in recipient twin with twin-to-twin transfusion syndrome: a case report. (19372698)
2009
27
The pediatric surgeons' contribution to in utero treatment of twin-to-twin transfusion syndrome. (19644353)
2009
28
Miniature bending manipulator for fetoscopic intrauterine laser therapy to treat twin-to-twin transfusion syndrome. (17661138)
2008
29
Discordance in nuchal translucency thickness in the prediction of severe twin-to-twin transfusion syndrome. (17444560)
2007
30
Comparing cranial ultrasound results in twin-to-twin transfusion syndrome treated with laser surgery. (17403389)
2007
31
Fetoscopic laser surgery in 100 pregnancies with severe twin-to-twin transfusion syndrome in the Netherlands. (17228157)
2007
32
Timely diagnosis of twin-to-twin transfusion syndrome in monochorionic twin pregnancies by biweekly sonography combined with patient instruction to report onset of symptoms. (16969785)
2006
33
Monochorionic diamniotic infants without twin-to-twin transfusion syndrome. (16281049)
2005
34
Twin-to-twin transfusion syndrome: a model for the fetal origins of adult health. (15670119)
2005
35
Magnetic resonance imaging of the feto-placentar unit after fetoscopic laser coagulation for twin-to-twin transfusion syndrome. (15981732)
2005
36
Minimal-access fetal surgery for twin-to-twin transfusion syndrome. (14625725)
2004
37
Pulmonary artery calcification in recipient twins of twin to twin transfusion syndrome: a report of three cases. (12574984)
2003
38
Twin reversed arterial perfusion sequence in twin-to-twin transfusion syndrome after the death of the donor co-twin in the second trimester. (11251926)
2001
39
Preoperative planning with magnetic resonance imaging and computerized volume rendering in twin-to-twin transfusion syndrome. (11483931)
2001
40
Pulmonary stenosis in recipient twins in twin-to-twin transfusion syndrome: report on 3 cases and review of literature. (10962042)
2000
41
Ultrasound in the diagnosis of twin-to-twin transfusion syndrome--a preliminary report. (10916568)
1998
42
Alternative technique for Nd: YAG laser coagulation in twin-to-twin transfusion syndrome with anterior placenta. (9644775)
1998
43
Severe twin-to-twin transfusion syndrome: a new sonographic feature of the placenta. (9286028)
1997
44
Amniotic fluid pressure in twin-to-twin transfusion syndrome: an objective prognostic factor. (8739584)
1996
45
Lenticulostriate vasculopathy in twin-to-twin transfusion syndrome: sonographic and CT findings. (8577550)
1995
46
Twin-to-twin transfusion syndrome type III--case report of an intrauterine death in monochorionic pregnancy. (7653204)
1995
47
Indomethacin in severe twin-to-twin transfusion syndrome. (8442793)
1993
48
Ultrasonography and Doppler studies in twin-to-twin transfusion syndrome. (1492805)
1992
49
Diagnosis of twin to twin transfusion syndrome at 18 weeks of gestation. (6417174)
1983
50
Twin-to-twin transfusion syndrome. (5198153)
1970

Variations for Twin-to-Twin Transfusion Syndrome

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Expression for genes affiliated with Twin-to-Twin Transfusion Syndrome

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Search GEO for disease gene expression data for Twin-to-Twin Transfusion Syndrome.

Pathways for genes affiliated with Twin-to-Twin Transfusion Syndrome

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Pathways related to Twin-to-Twin Transfusion Syndrome according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4VEGFC, EDN1
29.3VEGFC, REN, ANGPT2
3
Show member pathways
9.3ANGPT2, ANGPT1, VEGFC
4
Show member pathways
VEGFR1 specific signals38
9.2PGF, VEGFC
5
Show member pathways
9.2PGF, VEGFC
6
Show member pathways
9.2VEGFC, PGF
7
Show member pathways
8.9VEGFC, PGF, REN
8
Show member pathways
8.6EDN1, VEGFC, ANGPT1, ANGPT2
98.5NPPA, ANGPT2, ANGPT1, EDN1
10
Show member pathways
8.4VEGFC, PGF, ANGPT1, ANGPT2
11
Show member pathways
8.4VEGFC, PGF, ANGPT1, ANGPT2
128.4ANGPT2, ANGPT1, PGF, VEGFC
13
Show member pathways
8.4VEGFC, PGF, ANGPT1, ANGPT2
14
Show member pathways
8.4VEGFC, PGF, ANGPT1, ANGPT2
15
Show member pathways
8.4ANGPT2, ANGPT1, PGF, VEGFC

Compounds for genes affiliated with Twin-to-Twin Transfusion Syndrome

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Compounds related to Twin-to-Twin Transfusion Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 104)
idCompoundScoreTop Affiliating Genes
1ibopamine459.9NPPA, REN
2cicletanine459.9NPPA, REN
3isosorbide-5-mononitrate459.9NPPA, REN
4alacepril459.9NPPA, REN
551-cr-edta459.9NPPA, REN
6darusentan45 3010.8REN, EDN1
7lacidipine459.7REN, EDN1
8muraglitazar45 5110.7EDN1, REN
9fenoldopam45 1310.7REN, NPPA
10fludrocortisone45 30 1311.7REN, NPPA
11bisoprolol45 51 1311.6NPPA, REN
12ribonucleic acid459.6ANGPT1, VEGFC, ANGPT2
13moxonidine459.6NPPA, REN
14bq12345 3010.5NPPA, EDN1
15inulin459.5NPPA, REN
16progestin459.4ANGPT2, PAPPA, ANGPT1
17toki-shakuyaku-san459.4EDN1, REN, NPPA
18urodilatin459.4REN, NPPA, EDN1
19cilazapril45 1310.4NPPA, EDN1, REN
20omapatrilat459.4NPPA, REN, EDN1
21trandolapril45 1310.4NPPA, REN, EDN1
22hanp459.4REN, NPPA, EDN1
23quinapril45 51 1311.4EDN1, REN, NPPA
24enalaprilat459.4EDN1, REN, NPPA
25enalapril45 51 1311.4EDN1, NPPA, REN
26carvedilol45 51 30 1312.4NPPA, EDN1, REN
27guanylate459.4ANGPT2, ANGPT1, NPPA
28nitroglycerin45 1310.4NPPA, REN, EDN1
29captopril45 61 51 30 1313.3EDN1, REN, NPPA
30ang ii459.3NPPA, REN, EDN1
31sildenafil30 45 51 26 1313.3EDN1, ANGPT1, NPPA
32losartan45 51 30 1312.3EDN1, REN, NPPA
33sodium nitroprusside459.2EDN1, NPPA, REN
34nifedipine45 30 51 1312.0EDN1, REN, NPPA
35ng-nitro-l-arginine458.9EDN1, PGF, NPPA
36thymidine45 269.9ANGPT2, ANGPT1, VEGFC, EDN1
37matrigel458.8ANGPT2, ANGPT1, PGF, VEGFC
38cyclosporin a45 30 6110.8ANGPT1, EDN1, ANGPT2, NPPA
39paraffin458.8PGF, ANGPT2, ANGPT1, VEGFC
40cgmp45 309.7EDN1, REN, NPPA
41pge2458.6NPPA, EDN1, ANGPT2, VEGFC, REN
42pd 98,059458.5EDN1, VEGFC, PGF, ANGPT1
43phosphatidylinositol458.2ANGPT1, EDN1, PGF, ANGPT2, VEGFC
44prostacyclin458.1PGF, REN, NPPA, EDN1, ANGPT1
45glucose458.0PAPPA, ANGPT2, ANGPT1, VEGFC, PGF, REN
46oxygen45 268.7VEGFC, PGF, ANGPT1, ANGPT2, NPPA, EDN1
47creatinine457.7PAPPA, ANGPT2, REN, PGF, EDN1, NPPA
48nitric oxide45 26 139.4PGF, REN, ANGPT1, VEGFC, EDN1, NPPA
49vegf456.9EDN1, VEGFC, PGF, PAPPA, REN, ANGPT1
50calcium45 51 26 139.8NPPA, ANGPT1, ANGPT2, VEGFC, PGF, PAPPA

GO Terms for genes affiliated with Twin-to-Twin Transfusion Syndrome

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Cellular components related to Twin-to-Twin Transfusion Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055766.4VEGFC, PGF, PAPPA, REN, ANGPT1, ANGPT2
2extracellular spaceGO:00056156.1NPPA, EDN1, VEGFC, PGF, PAPPA, REN

Biological processes related to Twin-to-Twin Transfusion Syndrome according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1Tie signaling pathwayGO:004801410.0ANGPT2, ANGPT1
2glomerulus vasculature developmentGO:00720129.9ANGPT2, ANGPT1
3positive regulation of blood vessel endothelial cell migrationGO:00435369.9ANGPT1, VEGFC
4positive chemotaxisGO:00509189.8VEGFC, ANGPT1
5positive regulation of endothelial cell migrationGO:00105959.5ANGPT1, EDN1
6vascular endothelial growth factor receptor signaling pathwayGO:00480109.4PGF, VEGFC
7sprouting angiogenesisGO:00020409.4ANGPT1, PGF
8organ regenerationGO:00311009.4ANGPT2, PGF
9positive regulation of cell divisionGO:00517819.4PGF, VEGFC
10regulation of blood pressureGO:00082179.3NPPA, REN
11blood coagulationGO:00075969.3ANGPT2, ANGPT1, VEGFC
12female pregnancyGO:00075658.9PGF, PAPPA, NPPA
13cell differentiationGO:00301548.7PGF, PAPPA, ANGPT1
14positive regulation of cell proliferationGO:00082848.5PGF, VEGFC, EDN1
15response to hypoxiaGO:00016668.5NPPA, ANGPT2, PGF, EDN1

Molecular functions related to Twin-to-Twin Transfusion Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1receptor tyrosine kinase bindingGO:00309719.4ANGPT2, ANGPT1
2receptor bindingGO:00051029.2NPPA, ANGPT2, REN

Products for genes affiliated with Twin-to-Twin Transfusion Syndrome

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Sources for Twin-to-Twin Transfusion Syndrome

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet