MCID: TWN001
MIFTS: 51

Twin-to-Twin Transfusion Syndrome

Categories: Rare diseases, Blood diseases, Fetal diseases

Aliases & Classifications for Twin-to-Twin Transfusion Syndrome

MalaCards integrated aliases for Twin-to-Twin Transfusion Syndrome:

Name: Twin-to-Twin Transfusion Syndrome 38 12 72 49 14
Twin to Twin Transfusion Syndrome 49 55
Fetal Blood Loss from Fetal Hemorrhage into Co-Twin 12
Fetus-to-Fetus Placental Transfusion Syndrome 69
Feto-Fetal Transfusion Syndrome 55
Twin Twin Transfusion Syndrome 38
Fetofetal Transfusion Syndrome 49
Fetal Hemorrhage into Co-Twin 12
Twin-to-Twin Blood Transfer 12
Fetal Transfusion Syndrome 49
Twin to Twin Transfusion 12
Fetofetal Transfusion 41
Ttts 49

Classifications:



External Ids:

Disease Ontology 12 DOID:13576
ICD10 32 O43.02 O43.029
MeSH 41 D005330
NCIt 46 C113824
SNOMED-CT 64 13404009 237299001
Orphanet 55 ORPHA95431
ICD10 via Orphanet 33 O43.0
UMLS 69 C2909036

Summaries for Twin-to-Twin Transfusion Syndrome

NIH Rare Diseases : 49 Twin to twin transfusion syndrome (TTTS) is a rare condition that occurs during a twin pregnancy when blood moves from one twin (the “donor twin”) to the other (the “recipient twin”) while in the womb. TTTS is a complication that specifically occurs in identical (monozygotic) twin pregnancies that share the same "egg" sac (monochorionic) that may or may not share the same amniotic sac (monoamniotic). TTTS usually develops between 15 and 26 weeks of pregnancy. The donor twin may be born smaller, with paleness, anemia, and dehydration. The recipient twin may be born larger, with redness, too much blood, and increased blood pressure, resulting in an increased risk for heart failure. Treatment may require repeated amniocentesis during pregnancy. Fetal laser surgery may be done to interrupt the flow of blood from one twin to the other. After birth, treatment depends on the infant's specific symptoms. The donor twin may need a blood transfusion to treat anemia. The recipient twin may need to have the volume of body fluid reduced. This may involve an exchange transfusion. Medications may be given to treat heart failure in the recipient twin. Last updated: 7/21/2016

MalaCards based summary : Twin-to-Twin Transfusion Syndrome, also known as twin to twin transfusion syndrome, is related to limb ischemia and pulmonary hypertension. An important gene associated with Twin-to-Twin Transfusion Syndrome is PGF (Placental Growth Factor), and among its related pathways/superpathways are ERK Signaling and TGF-Beta Pathway. The drugs Progesterone and 11-hydroxyprogesterone have been mentioned in the context of this disorder. Affiliated tissues include heart, placenta and cervix, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 72 Twin-to-twin transfusion syndrome (TTTS), also known as feto-fetal transfusion syndrome (FFTS) and twin... more...

Related Diseases for Twin-to-Twin Transfusion Syndrome

Diseases related to Twin-to-Twin Transfusion Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 58)
# Related Disease Score Top Affiliating Genes
1 limb ischemia 29.8 ANGPT2 PGF
2 pulmonary hypertension 29.1 ANGPT1 ENG FLT1 REN
3 myocardial infarction 29.1 ANGPT1 ENG PGF REN
4 renal tubular dysgenesis 11.6
5 mild pre-eclampsia 10.3 FLT1 PGF
6 cerebritis 10.2
7 epithelioid hemangioendothelioma 10.2 FLT1 PGF
8 glomeruloid hemangioma 10.2 ENG FLT1
9 cancer-associated retinopathy 10.2 FLT1 PGF
10 cervicitis 10.2
11 vascular cancer 10.2 ENG FLT1
12 heart disease 10.1
13 polycythemia 10.1
14 polyhydramnios 10.1
15 congenital cytomegalovirus 10.0
16 cytomegalovirus infection 10.0
17 placental abruption 10.0 ENG FLT1 PGF
18 polymicrogyria, bilateral temporooccipital 10.0
19 hydranencephaly 10.0
20 polymicrogyria 10.0
21 eclampsia 10.0 ENG FLT1 PGF
22 hellp syndrome 10.0 ENG FLT1 PGF
23 pyogenic granuloma 10.0 ANGPT1 ANGPT2
24 macrophage activation syndrome 9.9 ANGPT1 ANGPT2
25 microvascular complications of diabetes 1 9.9 ANGPT2 FLT1
26 arteries, anomalies of 9.9 PGF REN
27 fibrosis of extraocular muscles, congenital, 1 9.9
28 down syndrome 9.9
29 enterocolitis 9.9
30 aging 9.9
31 anxiety 9.9
32 preterm premature rupture of the membranes 9.9
33 autoinflammation with infantile enterocolitis 9.9
34 hydrops fetalis, nonimmune, and/or atrial septal defect 9.9
35 arteriovenous fistula 9.9
36 cerebral palsy 9.9
37 arteriovenous malformation 9.9
38 oligohydramnios 9.9
39 post-traumatic stress disorder 9.9
40 ischemia 9.9
41 peritonitis 9.9
42 perinatal necrotizing enterocolitis 9.9
43 pulmonary embolism 9.9
44 amniotic band syndrome 9.9
45 hydrops fetalis 9.9
46 pandas 9.9
47 transposition of the great arteries 9.9
48 retinal vascular disease 9.9 ANGPT2 FLT1
49 epileptic encephalopathy, childhood-onset 9.9 ANGPT1 ANGPT2
50 placental insufficiency 9.9 ANGPT2 FLT1 PGF

Graphical network of the top 20 diseases related to Twin-to-Twin Transfusion Syndrome:



Diseases related to Twin-to-Twin Transfusion Syndrome

Symptoms & Phenotypes for Twin-to-Twin Transfusion Syndrome

MGI Mouse Phenotypes related to Twin-to-Twin Transfusion Syndrome:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.8 VEGFC ANGPT1 ANGPT2 ENG FLT1 PGF
2 homeostasis/metabolism MP:0005376 9.7 REN VEGFC ANGPT1 ANGPT2 ENG FLT1
3 immune system MP:0005387 9.43 REN VEGFC ANGPT1 ANGPT2 FLT1 PGF
4 mortality/aging MP:0010768 9.17 REN TUBB3 VEGFC ANGPT1 ANGPT2 ENG

Drugs & Therapeutics for Twin-to-Twin Transfusion Syndrome

Drugs for Twin-to-Twin Transfusion Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 27)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Progesterone Approved, Vet_approved Phase 3 57-83-0 5994
2 11-hydroxyprogesterone Phase 3
3 17-alpha-hydroxy-progesterone caproate Phase 3
4 Estrogen Antagonists Phase 3
5 Estrogens Phase 3
6 Hormone Antagonists Phase 3
7 Hormones Phase 3
8 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
9 Progestins Phase 3
10 Caproate Nutraceutical Phase 3
11
Epinephrine Approved, Vet_approved 51-43-4 5816
12
Lidocaine Approved, Vet_approved 137-58-6 3676
13 Racepinephrine Approved 329-65-7
14
Glucosamine Approved, Investigational, Nutraceutical 3416-24-8 439213
15 Anesthetics
16 Anti-Bacterial Agents
17 Antibiotics, Antitubercular
18 Anticoagulants
19 Antimetabolites
20 Epinephryl borate
21 Fibrinolytic Agents
22 Glucuronyl glucosamine glycan sulfate
23 Hypoglycemic Agents
24 Hypolipidemic Agents
25 Lipid Regulating Agents
26 Central Nervous System Depressants
27 Anesthetics, Local

Interventional clinical trials:

(show all 16)

# Name Status NCT ID Phase Drugs
1 Randomized Controlled Trial Comparing a Conservative Management and Laser Surgery Recruiting NCT01220011 Phase 4
2 Trial of Progesterone in Twins and Triplets to Prevent Preterm Birth (STTARS) Completed NCT00099164 Phase 3 17 alpha-hydroxyprogesterone caproate (17P)
3 Fetoscopic Selective Laser Photocoagulation in Twin-Twin Transfusion Syndrome Unknown status NCT00345852
4 Selective Laser Photocoagulation of Communicating Vessels in Twin-Twin Transfusion Syndrome Completed NCT01622049
5 Neonatal Outcome for Laser Coagulation in Twin-to-twin-transfusion Syndrome Completed NCT03151915
6 Anesthetic Management in Fetoscopic Surgery and Incidence of Complications Completed NCT02434926
7 Sequential vs. Standard Laser Treatment of Twin-twin Transfusion Syndrome Recruiting NCT02122328
8 Renal Artery Dopplers in Twin Twin Transfusion Syndrome Recruiting NCT03449823
9 The Trial of Pessary After Laser for TTTS Recruiting NCT01334489
10 Austrian Registry on the Outcome of Monochorionic Pregnancies Recruiting NCT03171909
11 Pessary to Prevent Prematurity in Twins in Case of Short Cervix Recruiting NCT02328989
12 Unequal Placental Sharing in Monochorionic Diamniotic Twins: an Observational Study Recruiting NCT03024918
13 The Utility of MRI Scoring to Predict Neurodevelopmental Outcomes in Survivors of Twin-to-Twin Transfusion Syndrome Active, not recruiting NCT02249624
14 Monochorial-diamniotic Pregnancies Complicated With a Twin-to-twin Syndrome Active, not recruiting NCT02611856
15 Laser Photocoagulation in Twin to Twin Transfusion Syndrome Enrolling by invitation NCT02506049
16 The Value of Prenatal Ultrasound in Complicated Twin Pregnancy and Its Correlation With Chromosomal Anomalies Not yet recruiting NCT02732717

Search NIH Clinical Center for Twin-to-Twin Transfusion Syndrome

Cochrane evidence based reviews: fetofetal transfusion

Genetic Tests for Twin-to-Twin Transfusion Syndrome

Anatomical Context for Twin-to-Twin Transfusion Syndrome

MalaCards organs/tissues related to Twin-to-Twin Transfusion Syndrome:

38
Heart, Placenta, Cervix, Brain, Eye, Bone, Liver

Publications for Twin-to-Twin Transfusion Syndrome

Articles related to Twin-to-Twin Transfusion Syndrome:

(show top 50) (show all 300)
# Title Authors Year
1
Fetal Doppler changes one week after endoscopic equatorial laser for twin-to-twin transfusion syndrome: a longitudinal study. ( 29436718 )
2018
2
Differential Changes in Myocardial Performance Index and Its Time Intervals in Donors and Recipients of Twin-to-Twin Transfusion Syndrome before and after Laser Therapy. ( 29353282 )
2018
3
Unusual course of hyperreactio luteinalis in twin pregnancy complicated by twin to twin transfusion syndrome. ( 29363826 )
2018
4
Impact of laser therapy for Twin-to-twin transfusion syndrome on subsequent pregnancy. ( 29417606 )
2018
5
Musical Interests and Talent: Twin Jazz Musicians and Twin Studies/Twin Research: Loss of a Preterm Multiple; Conjoined Twin Conception; Depression in Fathers of Twins; Twin-to-Twin Transfusion Syndrome/Twin News: High-Achieving Twins; Twin Children of a Tennis Star; Conjoined Twin Separation; Twin Delivery to a Giant Panda. ( 29103407 )
2017
6
Does the Site of The Cord Insertion increase the risk of Adverse Outcome, Twin-To-Twin Transfusion Syndrome and Discordant Growth in monochorionic twin pregnancies? ( 29024208 )
2017
7
Doppler assessment of patients with twin-to-twin transfusion syndrome and survival following fetoscopic laser surgery. ( 28281301 )
2017
8
Aortic and pulmonary artery calcification: An unusual manifestation of twin-to-twin transfusion syndrome. ( 28163434 )
2017
9
Modified diagnostic criteria for twin-to-twin transfusion syndrome prior to 18 weeks' gestation: time to change? ( 28236371 )
2017
10
Spontaneous resolution of mirror syndrome following fetal interventions for fetal anemia as a consequence of twin to twin transfusion syndrome. ( 27914652 )
2017
11
Arabin cervical pessary for prevention of preterm birth in cases of twin-to-twin transfusion syndrome treated by fetoscopic LASER coagulation: the PECEP LASER randomised controlled trial. ( 28764674 )
2017
12
Fetoscopic laser coagulation in 1020 pregnancies with twin-to-twin transfusion syndrome demonstrates improvement of double survival rates. ( 28477345 )
2017
13
Virtual three-dimensional placentoscopy: a new approach to assess residual anastomoses following laser photocoagulation in twin-to-twin transfusion syndrome. ( 28114847 )
2017
14
Late-onset transient adrenal insufficiency in preterm twins with twin-to-twin transfusion syndrome: A case report. ( 29381949 )
2017
15
Different patterns of left ventricular "rigid body rotation" in 8-year-old twins with anamnestic twin-to-twin transfusion syndrome (from the MAGYAR-Twin Study). ( 28275566 )
2017
16
Evolution of Stage 1 Twin-to-Twin Transfusion Syndrome (TTTS): Systematic Review and Meta-Analysis. ( 27137946 )
2016
17
Cardiac Manifestations of Twin-to-Twin Transfusion Syndrome. ( 27087122 )
2016
18
The History of Treatment of Twin-to-Twin Transfusion Syndrome. ( 27203604 )
2016
19
Fetal left modified myocardial performance index measured by the Auto Mod-MPI system: development of reference values and application to recipients of twin-to-twin transfusion syndrome. ( 26921842 )
2016
20
Laser Treatment of Twin-to-Twin Transfusion Syndrome. ( 27203606 )
2016
21
A prospective pilot study of fetoscopic laser surgery for twin-to-twin transfusion syndrome between 26 and 27 weeks of gestation. ( 27590373 )
2016
22
Monochorionic diamniotic inA vitro fertilization twins have a decreased incidence of twin-to-twin transfusion syndrome. ( 26690011 )
2016
23
Atypical twin-to-twin transfusion syndrome: prevalence inA aA populationA undergoing fetoscopic laser ablation of communicatingA placental vessels. ( 26827875 )
2016
24
Twin-to-Twin Transfusion Syndrome: Definition, Staging, and Ultrasound Assessment. ( 27203605 )
2016
25
Impact of Monochorionicity and Twin to Twin Transfusion Syndrome on Prenatal Attachment, Post Traumatic Stress Disorder, Anxiety and Depressive Symptoms. ( 26751570 )
2016
26
Increased Risk Of Early-Onset Neonatal Sepsis After Laser Surgery For Twin-to-Twin Transfusion Syndrome. ( 27137630 )
2016
27
Identifying families' shared disease experiences through a qualitative analysis of online twin-to-twin transfusion syndrome stories. ( 27422614 )
2016
28
Balancing Patient Access to Fetoscopic Laser Photocoagulation for Twin-to-Twin Transfusion Syndrome With Maintaining Procedural Competence: Are Collaborative Services Part of the Solution? ( 27087260 )
2016
29
The Placenta in Twin-to-Twin Transfusion Syndrome and Twin Anemia Polycythemia Sequence. ( 27098457 )
2016
30
The 2016 Satellite Meeting of the International Society of Twin Studies: An Overview/Tribute to Irving I. Gottesman/Research: MZ Twinning After Single Embryo Transfer; Twin Study of Mononucleosis; Cerebral Injury After Twin-To-Twin Transfusion Syndrome Surgery/Human Interest: Sixteen Twin Pairs Born in a Single Hospital; Death of an Identical Twin Playwright; Twin Themes in Advertising; Conjoined Twins Separated in Saudi Arabia; Murder of One Twin By Her Co-Twin Disproved. ( 27524469 )
2016
31
Future Directions in the Management of Twin-to-Twin Transfusion Syndrome. ( 27125296 )
2016
32
Early prediction of twin-to-twin transfusion syndrome: systematic review and meta-analysis. ( 27270878 )
2016
33
Intra-arterial calcifications in the recipient twin in twin-to-twin transfusion syndrome. ( 27834168 )
2016
34
Long-Term Neurodevelopmental Outcome in Survivors of Twin-to-Twin Transfusion Syndrome. ( 27137794 )
2016
35
Fetoscopic laser photocoagulation in twin-to-twin transfusion syndrome: experience from a single institution. ( 27056209 )
2016
36
Twin-to-Twin Transfusion Syndrome: From Observational Evidence to Randomized Controlled Trials. ( 27075108 )
2016
37
Visualisation of the vascular equator in twin-to-twin transfusion syndrome by virtual fetoscopy. ( 26411581 )
2015
38
Outcome following selective fetoscopic laser ablation for twin to twin transfusion syndrome: an 8 year national collaborative experience. ( 26117441 )
2015
39
Transient twin reversed arterial perfusion: a protective effect in twin-to-twin transfusion syndrome? ( 26360958 )
2015
40
Prediction of single fetal demise after laser therapy for twin-to-twin transfusion syndrome. ( 26395988 )
2015
41
Longitudinal annular displacement by M-mode (MAPSE and TAPSE) in twin-to-twin transfusion syndrome before and after laser surgery. ( 26256442 )
2015
42
Postnatal survival after endoscopic equatorial laser for the treatment of twin-to-twin transfusion syndrome. ( 26517964 )
2015
43
Pseudoamniotic Band Syndrome after In Utero Intervention for Twin-to-Twin Transfusion Syndrome: Case Reports and Literature Review. ( 25613236 )
2015
44
Short-Time Impact of Laser Ablation of Placental Anastomoses on Myocardial Function in Monochorionic Twins with Twin-to-Twin Transfusion Syndrome. ( 26331331 )
2015
45
Influences of Different Doses of Midazolam on Mother and Fetus in Fetoscopic Surgery for Twin-to-Twin Transfusion Syndrome. ( 26279077 )
2015
46
Congenital Cytomegalovirus Infection in Monozygotic Twins with Twin-to-twin Transfusion Syndrome. ( 26061933 )
2015
47
Perinatal outcome after fetoscopic laser surgery for twin-to-twin transfusion syndrome in triplet pregnancies: systematic review. ( 26265264 )
2015
48
Stage-Related Outcome after Fetoscopic Laser Ablation in Twin-to-Twin Transfusion Syndrome. ( 25096484 )
2014
49
Predictive value of cardiovascular parameters in stages 1 and 2 of twin-to-twin transfusion syndrome. ( 24760447 )
2014
50
Diagnosis of twin-to-twin transfusion syndrome, selective fetal growth restriction, twin anaemia-polycythaemia sequence, and twin reversed arterial perfusion sequence. ( 24433823 )
2014

Variations for Twin-to-Twin Transfusion Syndrome

Expression for Twin-to-Twin Transfusion Syndrome

Search GEO for disease gene expression data for Twin-to-Twin Transfusion Syndrome.

Pathways for Twin-to-Twin Transfusion Syndrome

Pathways related to Twin-to-Twin Transfusion Syndrome according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.44 ANGPT1 ANGPT2 FLT1 PGF TUBB3 VEGFC
2
Show member pathways
13.21 ANGPT1 ANGPT2 FLT1 PGF VEGFC
3
Show member pathways
13.09 ANGPT1 ANGPT2 FLT1 PGF VEGFC
4
Show member pathways
12.86 ANGPT1 ANGPT2 FLT1 PGF TUBB3 VEGFC
5
Show member pathways
12.74 FLT1 PGF REN VEGFC
6
Show member pathways
12.63 ANGPT1 ANGPT2 FLT1 PGF VEGFC
7
Show member pathways
12.38 FLT1 PGF VEGFC
8 12.32 ANGPT1 ANGPT2 FLT1 PGF VEGFC
9
Show member pathways
12.2 ANGPT1 ANGPT2 FLT1 PGF VEGFC
10
Show member pathways
12.07 FLT1 PGF VEGFC
11 11.82 ANGPT2 FLT1 VEGFC
12 11.63 ANGPT1 ANGPT2 FLT1
13
Show member pathways
11.57 FLT1 PGF VEGFC
14 11.14 ANGPT1 ANGPT2
15 10.97 ANGPT2 ENG FLT1 REN VEGFC
16 10.93 ANGPT2 ENG
17 10.89 ANGPT1 FLT1
18 10.67 ANGPT1 ANGPT2 FLT1 PGF VEGFC
19
Show member pathways
10.34 FLT1 PGF VEGFC

GO Terms for Twin-to-Twin Transfusion Syndrome

Cellular components related to Twin-to-Twin Transfusion Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.43 ANGPT1 ANGPT2 FLT1 PGF REN VEGFC
2 extracellular space GO:0005615 9.17 ANGPT1 ANGPT2 ENG FLT1 PGF REN

Biological processes related to Twin-to-Twin Transfusion Syndrome according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 multicellular organism development GO:0007275 9.89 ANGPT1 ANGPT2 FLT1 PGF VEGFC
2 cell differentiation GO:0030154 9.85 ANGPT1 ANGPT2 FLT1 PGF VEGFC
3 response to drug GO:0042493 9.73 ENG PGF REN VEGFC
4 response to hypoxia GO:0001666 9.69 ANGPT2 PGF VEGFC
5 positive regulation of endothelial cell proliferation GO:0001938 9.58 PGF VEGFC
6 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.58 ANGPT1 FLT1
7 positive regulation of cell division GO:0051781 9.57 PGF VEGFC
8 animal organ regeneration GO:0031100 9.56 ANGPT2 PGF
9 positive chemotaxis GO:0050918 9.55 ANGPT1 VEGFC
10 positive regulation of blood vessel endothelial cell migration GO:0043536 9.54 ANGPT1 VEGFC
11 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.54 FLT1 PGF VEGFC
12 blood vessel morphogenesis GO:0048514 9.52 ANGPT2 FLT1
13 induction of positive chemotaxis GO:0050930 9.48 PGF VEGFC
14 positive regulation of mast cell chemotaxis GO:0060754 9.4 PGF VEGFC
15 positive regulation of angiogenesis GO:0045766 9.35 ANGPT2 ENG FLT1 PGF VEGFC
16 sprouting angiogenesis GO:0002040 9.33 ANGPT1 ENG PGF
17 glomerulus vasculature development GO:0072012 9.32 ANGPT1 ANGPT2
18 Tie signaling pathway GO:0048014 9.26 ANGPT1 ANGPT2
19 angiogenesis GO:0001525 9.1 ANGPT1 ANGPT2 ENG FLT1 PGF VEGFC

Molecular functions related to Twin-to-Twin Transfusion Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 receptor binding GO:0005102 9.13 ANGPT1 ANGPT2 REN
2 receptor tyrosine kinase binding GO:0030971 8.62 ANGPT1 ANGPT2

Sources for Twin-to-Twin Transfusion Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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