MCID: TWN001
MIFTS: 54

Twin-to-Twin Transfusion Syndrome malady

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Summaries for Twin-to-Twin Transfusion Syndrome

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Wikipedia:65 Twin-to-twin transfusion syndrome (TTTS, also known as Feto-Fetal Transfusion Syndrome (FFTS) and Twin... more...

MalaCards based summary: Twin-to-Twin Transfusion Syndrome, also known as twin to twin transfusion, is related to hyperaldosteronism and congenital heart disease. An important gene associated with Twin-to-Twin Transfusion Syndrome is ANGPT2 (angiopoietin 2), and among its related pathways are HIF1Alpha Pathway and Angiogenesis. The compounds isosorbide-5-mononitrate and cicletanine have been mentioned in the context of this disorder. Affiliated tissues include placenta, heart and brain, and related mouse phenotypes are muscle and renal/urinary system.

Aliases & Classifications for Twin-to-Twin Transfusion Syndrome

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Sources:
8Disease Ontology, 10DISEASES, 62UMLS, 48Orphanet, 34MeSH, 57SNOMED-CT, 26ICD10 via Orphanet
See all sources

Twin-to-Twin Transfusion Syndrome, Aliases & Descriptions:

Name: Twin-to-Twin Transfusion Syndrome 8 10
Twin to Twin Transfusion 8 62
Fetal Blood Loss from Fetal Hemorrhage into Co-Twin 8
Ffts - Fetofetal Transfusion Syndrome 62
Twin to Twin Transfusion Syndrome 48
 
Feto-Fetal Transfusion Syndrome 48
Fetal Haemorrhage into Co-Twin 62
Fetal Hemorrhage into Co-Twin 8
Twin-to-Twin Blood Transfer 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Blood diseases


External Ids:

Disease Ontology8 DOID:13576
MeSH34 D005330
ICD10 via Orphanet26 O43.0

Related Diseases for Twin-to-Twin Transfusion Syndrome

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Diseases in the Twin-to-Twin Transfusion Syndrome family:

Twin Twin Transfusion Syndrome

Diseases related to Twin-to-Twin Transfusion Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 75)
idRelated DiseaseScoreTop Affiliating Genes
1hyperaldosteronism30.7REN, NPPA
2congenital heart disease30.6EDN1, NPPA
3pulmonary hypertension30.2EDN1, ANGPT1, NPPA
4hypertension30.0NPPA, REN, PGF, EDN1
5ischemia29.8EDN1, VEGFC, PGF, ANGPT1, ANGPT2
6myocardial infarction29.4EDN1, PGF, PAPPA, REN, ANGPT1, NPPA
7cerebritis10.6
8twin twin transfusion syndrome10.6
9polyhydramnios10.6
10cervicitis10.6
11hypoaldosteronism10.5REN
12polycythemia10.5
13congestive heart failure10.4REN
14pre-eclampsia10.3PAPPA
15placental insufficiency10.3PGF, ANGPT2
16arteriovenous fistula10.3
17cerebral palsy10.3
18down syndrome10.3
19limb ischemia10.3
20arteriovenous malformation10.3
21oligohydramnios10.3
22peritonitis10.3
23pulmonary embolism10.3
24amniotic band syndrome10.3
25congenital cytomegalovirus10.3
26hydrops fetalis10.3
27transposition of the great arteries10.3
28cytomegalovirus infection10.3
29pyogenic granuloma10.3ANGPT2, ANGPT1
30renovascular hypertension10.2REN, NPPA
31gestational diabetes10.2PAPPA, PGF
32diabetic retinopathy10.2ANGPT2, PGF
33pure autonomic failure10.2REN, NPPA
34conn's syndrome10.2REN, NPPA
35hemangioma10.2ANGPT1, ANGPT2
36acute kidney failure10.1REN, NPPA
37papillary thyroid carcinoma10.1ANGPT2, VEGFC
38renal hypertension10.1EDN1, REN
39portal hypertension10.1REN, EDN1
40low renin hypertension10.1EDN1, REN
41angiosarcoma10.1ANGPT2, ANGPT1, VEGFC
42thyroid hurthle cell carcinoma10.1ANGPT2, ANGPT1, VEGFC
43endometrial carcinoma10.0VEGFC, ANGPT1, ANGPT2
44stomach cancer10.0VEGFC, ANGPT1, ANGPT2
45cor pulmonale10.0EDN1, NPPA
46idiopathic edema10.0EDN1, NPPA
47arteriosclerosis10.0EDN1, ANGPT1
48primary pulmonary hypertension10.0NPPA, EDN1
49glomerulosclerosis10.0EDN1, REN
50glioblastoma10.0ANGPT2, ANGPT1, VEGFC

Graphical network of the top 20 diseases related to Twin-to-Twin Transfusion Syndrome:



Diseases related to twin-to-twin transfusion syndrome

Symptoms for Twin-to-Twin Transfusion Syndrome

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Drugs & Therapeutics for Twin-to-Twin Transfusion Syndrome

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Drug clinical trials:

Search ClinicalTrials for Twin-to-Twin Transfusion Syndrome

Search NIH Clinical Center for Twin-to-Twin Transfusion Syndrome

Genetic Tests for Twin-to-Twin Transfusion Syndrome

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Anatomical Context for Twin-to-Twin Transfusion Syndrome

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MalaCards organs/tissues related to Twin-to-Twin Transfusion Syndrome:

32
Placenta, Heart, Brain, Eye, Bone, Liver, Cervix

Animal Models for Twin-to-Twin Transfusion Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Twin-to-Twin Transfusion Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.5NPPA, ANGPT1, REN, EDN1
2MP:00053678.2EDN1, REN, ANGPT1, NPPA
3MP:00053766.8EDN1, VEGFC, PGF, PAPPA, REN, ANGPT2
4MP:00053856.4NPPA, EDN1, VEGFC, PGF, PAPPA, REN

Publications for Twin-to-Twin Transfusion Syndrome

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Articles related to Twin-to-Twin Transfusion Syndrome:

(show top 50)    (show all 246)
idTitleAuthorsYear
1
Congenital heart disease in monochorionic twins with and without twin-to-twin transfusion syndrome. (24827120)
2014
2
Diagnosis of twin-to-twin transfusion syndrome, selective fetal growth restriction, twin anaemia-polycythaemia sequence, and twin reversed arterial perfusion sequence. (24433823)
2014
3
Iatrogenic perforation of intertwin membrane after laser surgery for twin-to-twin transfusion syndrome. (24961923)
2014
4
Predictive value of cardiovascular parameters in stages 1 and 2 of twin-to-twin transfusion syndrome. (24760447)
2014
5
Twin-to-twin transfusion syndrome: knowing our boundaries. (24613025)
2014
6
Fetoscopic laser coagulation of the vascular equator versus selective coagulation for twin-to-twin transfusion syndrome: an open-label randomised controlled trial. (24613024)
2014
7
Fetoscopic laser therapy for twin-to-twin transfusion syndrome. (23395141)
2013
8
Preoperative prediction of the individualized risk of early fetal death after laser therapy in twin-to-twin transfusion syndrome. (23813911)
2013
9
Twin-to-twin transfusion syndrome: a case study. (23360857)
2013
10
Neonatal urinary ascites complicated by ileal perforation in a recipient of twin-to-twin transfusion syndrome. (23255026)
2013
11
Fetal and maternal complications after selective fetoscopic laser surgery for twin-to-twin transfusion syndrome: a single-center experience. (22456330)
2012
12
Evaluation of the measurement of the middle cerebral artery peak systolic velocity before and after placental laser coagulation in twin-to-twin transfusion syndrome. (22418955)
2012
13
Evaluation of cardiac performance by abdominal fetal ECG in twin-to-twin transfusion syndrome. (22886606)
2012
14
Arabin cervical pessary to prevent preterm birth in severe twin-to-twin transfusion syndrome treated by laser surgery. (23055333)
2012
15
Sonography-based Automated Volume Count to estimate fetal urine production in twin-to-twin transfusion syndrome: comparison with Virtual Organ Computer-aided AnaLysis. (21906713)
2011
16
Laser therapy for twin-to-twin transfusion syndrome causing amniotic band syndrome. (21037281)
2011
17
Laser ablation of placental vessels in twin-to-twin transfusion syndrome: a paradigm for endoscopic fetal surgery. (21854207)
2011
18
Laser therapy for twin-to-twin transfusion syndrome (TTTS). (21660997)
2011
19
The Fetal Heart in Twin-to-Twin Transfusion Syndrome. (20811613)
2010
20
Prospective assessment of fetal cardiac function with speckle tracking in healthy fetuses and recipient fetuses of twin-to-twin transfusion syndrome. (20138468)
2010
21
Management of Stage I twin-to-twin transfusion syndrome: an international survey. (20104530)
2010
22
Amniotic fluid markers of fetal cardiac dysfunction in twin-to-twin transfusion syndrome. (19801144)
2010
23
Preoperative predictors of death in twin-to-twin transfusion syndrome treated with laser ablation of placental anastomoses. (20691964)
2010
24
Survival after laser surgery for twin-to-twin transfusion syndrome: when are they out of the woods? (19159719)
2009
25
Extreme polycythemia in recipient twin with twin-to-twin transfusion syndrome: a case report. (19372698)
2009
26
Twin-to-twin transfusion syndrome: what nurses need to know. (19523136)
2009
27
The pediatric surgeons' contribution to in utero treatment of twin-to-twin transfusion syndrome. (19644353)
2009
28
Miniature bending manipulator for fetoscopic intrauterine laser therapy to treat twin-to-twin transfusion syndrome. (17661138)
2008
29
Discordance in nuchal translucency thickness in the prediction of severe twin-to-twin transfusion syndrome. (17444560)
2007
30
Comparing cranial ultrasound results in twin-to-twin transfusion syndrome treated with laser surgery. (17403389)
2007
31
Timely diagnosis of twin-to-twin transfusion syndrome in monochorionic twin pregnancies by biweekly sonography combined with patient instruction to report onset of symptoms. (16969785)
2006
32
Monochorionic diamniotic infants without twin-to-twin transfusion syndrome. (16281049)
2005
33
Twin-to-twin transfusion syndrome: a model for the fetal origins of adult health. (15670119)
2005
34
Magnetic resonance imaging of the feto-placentar unit after fetoscopic laser coagulation for twin-to-twin transfusion syndrome. (15981732)
2005
35
Minimal-access fetal surgery for twin-to-twin transfusion syndrome. (14625725)
2004
36
Pulmonary artery calcification in recipient twins of twin to twin transfusion syndrome: a report of three cases. (12574984)
2003
37
Use of continuous fluid drainage for severe polyhydramnios due to twin to twin transfusion syndrome. (11491373)
2001
38
Twin reversed arterial perfusion sequence in twin-to-twin transfusion syndrome after the death of the donor co-twin in the second trimester. (11251926)
2001
39
Preoperative planning with magnetic resonance imaging and computerized volume rendering in twin-to-twin transfusion syndrome. (11483931)
2001
40
Pulmonary stenosis in recipient twins in twin-to-twin transfusion syndrome: report on 3 cases and review of literature. (10962042)
2000
41
Ultrasound in the diagnosis of twin-to-twin transfusion syndrome--a preliminary report. (10916568)
1998
42
Alternative technique for Nd: YAG laser coagulation in twin-to-twin transfusion syndrome with anterior placenta. (9644775)
1998
43
Severe twin-to-twin transfusion syndrome: a new sonographic feature of the placenta. (9286028)
1997
44
Amniotic fluid pressure in twin-to-twin transfusion syndrome: an objective prognostic factor. (8739584)
1996
45
Lenticulostriate vasculopathy in twin-to-twin transfusion syndrome: sonographic and CT findings. (8577550)
1995
46
Twin-to-twin transfusion syndrome type III--case report of an intrauterine death in monochorionic pregnancy. (7653204)
1995
47
Indomethacin in severe twin-to-twin transfusion syndrome. (8442793)
1993
48
Ultrasonography and Doppler studies in twin-to-twin transfusion syndrome. (1492805)
1992
49
Diagnosis of twin to twin transfusion syndrome at 18 weeks of gestation. (6417174)
1983
50
Twin-to-twin transfusion syndrome. (5198153)
1970

Variations for Twin-to-Twin Transfusion Syndrome

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Expression for genes affiliated with Twin-to-Twin Transfusion Syndrome

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Expression patterns in normal tissues for genes affiliated with Twin-to-Twin Transfusion Syndrome

Search GEO for disease gene expression data for Twin-to-Twin Transfusion Syndrome.

Pathways for genes affiliated with Twin-to-Twin Transfusion Syndrome

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Pathways related to Twin-to-Twin Transfusion Syndrome according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4VEGFC, EDN1
29.3VEGFC, REN, ANGPT2
3
Show member pathways
9.3ANGPT2, ANGPT1, VEGFC
4
Show member pathways
VEGFR1 specific signals37
9.2PGF, VEGFC
5
Show member pathways
9.2PGF, VEGFC
6
Show member pathways
9.2VEGFC, PGF
7
Show member pathways
8.9VEGFC, PGF, REN
8
Show member pathways
8.6EDN1, VEGFC, ANGPT1, ANGPT2
98.5NPPA, ANGPT2, ANGPT1, EDN1
10
Show member pathways
8.4VEGFC, PGF, ANGPT1, ANGPT2
11
Show member pathways
8.4VEGFC, PGF, ANGPT1, ANGPT2
128.4ANGPT2, ANGPT1, PGF, VEGFC
13
Show member pathways
8.4VEGFC, PGF, ANGPT1, ANGPT2
14
Show member pathways
8.4VEGFC, PGF, ANGPT1, ANGPT2
15
Show member pathways
8.4ANGPT2, ANGPT1, PGF, VEGFC

Compounds for genes affiliated with Twin-to-Twin Transfusion Syndrome

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Compounds related to Twin-to-Twin Transfusion Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 104)
idCompoundScoreTop Affiliating Genes
1isosorbide-5-mononitrate449.9REN, NPPA
2cicletanine449.9REN, NPPA
3ibopamine449.9NPPA, REN
4alacepril449.9REN, NPPA
551-cr-edta449.9REN, NPPA
6darusentan44 2810.8REN, EDN1
7lacidipine449.7EDN1, REN
8muraglitazar44 5010.7EDN1, REN
9fenoldopam44 1110.7REN, NPPA
10fludrocortisone44 28 1111.7REN, NPPA
11bisoprolol44 50 1111.6NPPA, REN
12ribonucleic acid449.6VEGFC, ANGPT1, ANGPT2
13fosinopril44 1110.6REN, NPPA
14bq12344 2810.5NPPA, EDN1
15inulin449.5REN, NPPA
16progestin449.4ANGPT2, PAPPA, ANGPT1
17toki-shakuyaku-san449.4EDN1, REN, NPPA
18urodilatin449.4REN, NPPA, EDN1
19trandolapril44 1110.4REN, EDN1, NPPA
20cilazapril44 1110.4REN, EDN1, NPPA
21omapatrilat449.4EDN1, REN, NPPA
22hanp449.4EDN1, REN, NPPA
23quinapril44 50 1111.4EDN1, REN, NPPA
24enalaprilat449.4NPPA, REN, EDN1
25enalapril44 50 1111.4EDN1, REN, NPPA
26carvedilol44 50 28 1112.4NPPA, REN, EDN1
27guanylate449.4ANGPT2, NPPA, ANGPT1
28nitroglycerin44 1110.4REN, NPPA, EDN1
29captopril44 61 50 28 1113.3EDN1, REN, NPPA
30ang ii449.3NPPA, REN, EDN1
31sildenafil28 44 50 24 1113.3NPPA, ANGPT1, EDN1
32losartan44 50 28 1112.3NPPA, REN, EDN1
33sodium nitroprusside449.2REN, NPPA, EDN1
34nifedipine44 28 50 1112.0EDN1, REN, NPPA
35ng-nitro-l-arginine448.9NPPA, EDN1, PGF
36thymidine44 249.9ANGPT2, ANGPT1, VEGFC, EDN1
37matrigel448.8ANGPT2, ANGPT1, PGF, VEGFC
38cyclosporin a44 28 6110.8ANGPT1, EDN1, ANGPT2, NPPA
39paraffin448.8ANGPT2, ANGPT1, PGF, VEGFC
40cgmp44 289.7EDN1, NPPA, REN
41pge2448.6NPPA, ANGPT2, VEGFC, EDN1, REN
42pd 98,059448.5VEGFC, EDN1, ANGPT1, PGF
43phosphatidylinositol448.2PGF, ANGPT2, ANGPT1, VEGFC, EDN1
44prostacyclin448.1PGF, REN, NPPA, EDN1, ANGPT1
45glucose448.0ANGPT2, REN, PAPPA, PGF, ANGPT1, VEGFC
46oxygen44 248.7VEGFC, ANGPT2, ANGPT1, PGF, EDN1, NPPA
47creatinine447.7PAPPA, ANGPT2, REN, PGF, EDN1, NPPA
48nitric oxide44 24 119.4PGF, REN, ANGPT1, VEGFC, EDN1, NPPA
49vegf446.9EDN1, VEGFC, PGF, PAPPA, REN, ANGPT1
50calcium44 50 24 119.8NPPA, ANGPT1, ANGPT2, VEGFC, PGF, PAPPA

GO Terms for genes affiliated with Twin-to-Twin Transfusion Syndrome

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Cellular components related to Twin-to-Twin Transfusion Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055766.4VEGFC, PGF, PAPPA, REN, ANGPT1, ANGPT2
2extracellular spaceGO:0056156.1NPPA, EDN1, VEGFC, PGF, PAPPA, REN

Biological processes related to Twin-to-Twin Transfusion Syndrome according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1Tie signaling pathwayGO:04801410.0ANGPT2, ANGPT1
2glomerulus vasculature developmentGO:0720129.9ANGPT2, ANGPT1
3positive regulation of blood vessel endothelial cell migrationGO:0435369.9ANGPT1, VEGFC
4positive chemotaxisGO:0509189.8VEGFC, ANGPT1
5positive regulation of endothelial cell migrationGO:0105959.5ANGPT1, EDN1
6vascular endothelial growth factor receptor signaling pathwayGO:0480109.4PGF, VEGFC
7sprouting angiogenesisGO:0020409.4ANGPT1, PGF
8organ regenerationGO:0311009.4ANGPT2, PGF
9positive regulation of cell divisionGO:0517819.4PGF, VEGFC
10regulation of blood pressureGO:0082179.3NPPA, REN
11blood coagulationGO:0075969.3ANGPT2, ANGPT1, VEGFC
12female pregnancyGO:0075658.9PGF, PAPPA, NPPA
13cell differentiationGO:0301548.7PGF, PAPPA, ANGPT1
14positive regulation of cell proliferationGO:0082848.5PGF, VEGFC, EDN1
15response to hypoxiaGO:0016668.5NPPA, ANGPT2, PGF, EDN1

Molecular functions related to Twin-to-Twin Transfusion Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1receptor tyrosine kinase bindingGO:0309719.4ANGPT2, ANGPT1
2receptor bindingGO:0051029.2NPPA, ANGPT2, REN

Products for genes affiliated with Twin-to-Twin Transfusion Syndrome

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Sources for Twin-to-Twin Transfusion Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet