MCID: TWN001
MIFTS: 58

Twin-to-Twin Transfusion Syndrome malady

Blood diseases category

Summaries for Twin-to-Twin Transfusion Syndrome

About this section
Sources:
63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:63 Twin-to-twin transfusion syndrome (TTTS, also known as Feto-Fetal Transfusion Syndrome (FFTS) and Twin... more...

MalaCards: Twin-to-Twin Transfusion Syndrome, also known as fetal blood loss from fetal hemorrhage into co-twin, is related to polyhydramnios and polycythemia. An important gene associated with Twin-to-Twin Transfusion Syndrome is ASPRV1 (aspartic peptidase, retroviral-like 1), and among its related pathways are Rheumatoid arthritis and Pathways in cancer. The compounds mannitol and toki-shakuyaku-san have been mentioned in the context of this disorder. Affiliated tissues include placenta, heart and brain, and related mouse phenotypes are renal/urinary system and embryogenesis.

Aliases & Classifications for Twin-to-Twin Transfusion Syndrome

About this section
Sources:
8Disease Ontology, 10DISEASES, 48Orphanet, 60UMLS, 56SNOMED-CT, 34MeSH, 57SNOMED-CT via Orphanet, 26ICD10 via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Blood diseases


Aliases & Descriptions:

twin-to-twin transfusion syndrome 8 10
fetal blood loss from fetal hemorrhage into co-twin 8
ffts - fetofetal transfusion syndrome 60
twin to twin transfusion syndrome 48
feto-fetal transfusion syndrome 48
fetal hemorrhage into co-twin 8
twin-to-twin blood transfer 8
twin to twin transfusion 8


External Ids:

Disease Ontology8 DOID:13576
MeSH34 D005330
SNOMED-CT via Orphanet57 13404009
ICD10 via Orphanet26 O43.0

Related Diseases for Twin-to-Twin Transfusion Syndrome

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Twin-to-Twin Transfusion Syndrome family:

Twin Twin Transfusion Syndrome

Diseases related to Twin-to-Twin Transfusion Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 184)
idRelated DiseaseScoreTop Affiliating Genes
1polyhydramnios30.7AFP
2polycythemia30.6HIF1A
3oligohydramnios30.4AFP
4pulmonary embolism30.4ALB
5peritonitis30.4ALB, B2M
6down syndrome30.4PGF, PAPPA, AFP
7hypertension30.4CST3, NPPA, EDN1, REN, ALB, PGF
8myocardial infarction30.4CST3, NPPA, ANGPT1, HIF1A, REN, PGF
9ischemia30.3PGF, ANGPT1, VEGFC, VEGFA, EDN1, FLT1
10cerebritis10.6
11cervicitis10.5
12twin twin transfusion syndrome10.5
13n syndrome10.4
14image syndrome10.4
15arteriovenous fistula10.3
16arteriovenous malformation10.3
17adult syndrome10.3
18cerebral palsy10.3
19hyperaldosteronism10.3
20gingivitis10.0CST3
21hepatitis10.0AFP
22hypothyroidism10.0CST3
23cerebrovascular disease10.0CST3
24amyotrophic lateral sclerosis10.0CST3
25vesicoureteral reflux10.0AMBP
26multiple myeloma10.0B2M
27gastroschisis10.0AFP
28galactosemia10.0ALB
29portal vein thrombosis10.0AFP
30vasculitis10.0ALB
31glaucoma10.0EDN1
32congenital heart defect10.0NPPA
33pancreatitis10.0ALB
34viral hepatitis10.0AFP
35neuropathy10.0ALB
36meningitis10.0ALB
37hepatitis e10.0AMBP
38kidney cancer10.0VEGFA
39pulmonary fibrosis10.0EDN1
40crohn's disease10.0ALB
41brain edema10.0ALB
42blindness10.0VEGFA
43lupus nephritis10.0ALB
44cholestasis10.0ALB
45hyperparathyroidism10.0ALB
46rhinitis10.0ALB
47hypoaldosteronism10.0REN
48poems syndrome10.0VEGFA
49chondrosarcoma10.0AMBP
50varicose veins10.0ALB

Graphical network of the top 20 diseases related to Twin-to-Twin Transfusion Syndrome:



Diseases related to twin-to-twin transfusion syndrome

Clinical Features for Twin-to-Twin Transfusion Syndrome

About this section

Drugs & Therapeutics for Twin-to-Twin Transfusion Syndrome

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Twin-to-Twin Transfusion Syndrome

Drug clinical trials:

Search ClinicalTrials for Twin-to-Twin Transfusion Syndrome

Search NIH Clinical Center for Twin-to-Twin Transfusion Syndrome

Search CenterWatch for Twin-to-Twin Transfusion Syndrome

Genetic Tests for Twin-to-Twin Transfusion Syndrome

About this section

Anatomical Context for Twin-to-Twin Transfusion Syndrome

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Twin-to-Twin Transfusion Syndrome:

32
Placenta, Heart, Brain, Eye, Bone, Liver, Cervix

Animal Models for Twin-to-Twin Transfusion Syndrome or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Twin-to-Twin Transfusion Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053679.2EDN1, ANGPT1, HIF1A, REN
2MP:00053809.1AMBP, EDN1, PGF
3MP:00053698.7CST3, NPPA, FLT1, ANGPT1, HIF1A, REN
4MP:00053768.7CST3, NPPA, B2M, AFP, REN, PGF
5MP:00053818.6ALB, HIF1A, ANGPT2, VEGFA, B2M, EDN1
6MP:00020068.3CST3, B2M, AFP, VEGFA, HIF1A, PGF
7MP:00028737.6EDN1, FLT1, VEGFA, HIF1A, REN, ALB
8MP:00107687.0EDN1, FLT1, B2M, AFP, VEGFA, VEGFC
9MP:00053856.9ADD3, CST3, NPPA, EDN1, FLT1, B2M

Publications for Twin-to-Twin Transfusion Syndrome

About this section
Sources:
50PubMed
See all sources

Articles related to Twin-to-Twin Transfusion Syndrome:

(show top 50)    (show all 230)
idTitleAuthorsYear
1
Preoperative prediction of the individualized risk of early fetal death after laser therapy in twin-to-twin transfusion syndrome. (23813911)
2013
2
Outcome after fetoscopic selective laser ablation of placental anastomoses vs equatorial laser dichorionization for the treatment of twin-to-twin transfusion syndrome. (23707807)
2013
3
Laser ablation of placental anastomoses in twin-to-twin transfusion syndrome: preoperative predictors of death by recursive partitioning. (23386469)
2013
4
Fetal Limb Ischaemia in Twin-to-Twin Transfusion Syndrome. (24386580)
2013
5
Neonatal outcome following long-distance air travel for fetoscopic laser coagulation treatment of twin-to-twin transfusion syndrome. (22445425)
2012
6
Renin is activated in monochorionic diamniotic twins with birthweight discordance who do not have twin-to-twin transfusion syndrome. (21941232)
2012
7
Establishing a national program for fetoscopic guided laser occlusion for twin-to-twin transfusion syndrome in Sweden. (22568938)
2012
8
Fetoscopic laser surgery for twin-to-twin transfusion syndrome after 26 weeks of gestation. (22156583)
2012
9
Meconium peritonitis in both fetuses with early twin-to-twin transfusion syndrome. (22853881)
2012
10
Clinical and biochemical predictors of very preterm birth in twin-to-twin transfusion syndrome treated by fetoscopy. (20950791)
2011
11
Prognosis and long-term neurodevelopmental outcome in conservatively treated twin-to-twin transfusion syndrome. (21510908)
2011
12
The Fetal Heart in Twin-to-Twin Transfusion Syndrome. (20811613)
2010
13
Placental markers of twin-to-twin transfusion syndrome in diamniotic-monochorionic twins: A morphometric analysis of deep artery-to-vein anastomoses. (20064658)
2010
14
Fetoscopic laser coagulation for severe twin-to-twin transfusion syndrome: factors influencing perinatal outcome, learning curve of the procedure and lessons for new centres. (20670301)
2010
15
Twin to twin transfusion syndrome. (21209514)
2010
16
Fatal pulmonary embolism in a premature neonate after twin-to-twin transfusion syndrome. (20603263)
2010
17
Extreme polycythemia in recipient twin with twin-to-twin transfusion syndrome: a case report. (19372698)
2009
18
Twin-to-twin transfusion syndrome: what nurses need to know. (19523136)
2009
19
The pediatric surgeons' contribution to in utero treatment of twin-to-twin transfusion syndrome. (19644353)
2009
20
Assessment of fetal cardiac function before and after therapy for twin-to-twin transfusion syndrome. (19318149)
2009
21
Maternal serum markers of placental damage in uncomplicated dichorionic and monochorionic pregnancies in comparison with monochorionic pregnancies complicated by severe twin-to-twin transfusion syndrome and the response to fetoscopic laser ablation. (19362410)
2009
22
Residual anastomoses in twin-to-twin transfusion syndrome treated with selective fetoscopic laser surgery: localization, size, and consequences. (19306965)
2009
23
Miniature bending manipulator for fetoscopic intrauterine laser therapy to treat twin-to-twin transfusion syndrome. (17661138)
2008
24
Update on twin-to-twin transfusion syndrome. (18262471)
2008
25
Long-term outcome of infants with twin-to-twin transfusion syndrome. (17003558)
2007
26
Three-dimensional sonographic assessment of fetal urine production before and after laser surgery in twin-to-twin transfusion syndrome. (18044798)
2007
27
An ethically justified decision-making pathway for the management of pregnancies complicated by twin-to-twin transfusion syndrome. (17556820)
2007
28
Intratwin arteriovenous fistula of the placenta in a case of twin-to-twin transfusion syndrome. (15668837)
2005
29
Laser for the treatment of twin to twin transfusion syndrome. (16302086)
2005
30
Analysis of fetal growth after laser therapy in twin-to-twin transfusion syndrome. (16123181)
2005
31
Limited prognostic value of a staging system for twin-to-twin transfusion syndrome. (15067245)
2004
32
Placental findings after laser ablation of communicating vessels in twin-to-twin transfusion syndrome. (15022066)
2004
33
Antenatal necrotic injury in severe twin-to-twin transfusion syndrome. A case and review. (15192299)
2004
34
Twin to twin transfusion syndrome: a patient's perspective. (14979301)
2003
35
Preterm premature rupture of membrane and twin-to-twin transfusion syndrome before 20 weeks: a favourable outcome. (12065956)
2002
36
Preoperative planning with magnetic resonance imaging and computerized volume rendering in twin-to-twin transfusion syndrome. (11483931)
2001
37
Sono-endoscopic delineation of the placental vascular equator prior to selective fetoscopic laser ablation in twin-to-twin transfusion syndrome. (11169287)
2000
38
Minimally invasive treatment of twin-to-twin transfusion syndrome. (10806536)
2000
39
Early prediction of severe twin-to-twin transfusion syndrome. (10967005)
2000
40
Ultrasound in the diagnosis of twin-to-twin transfusion syndrome--a preliminary report. (10916568)
1998
41
Colour Doppler energy insonation of placental vasculature in monochorionic twins: absent arterio-arterial anastomoses in association with twin-to-twin transfusion syndrome. (9692418)
1998
42
Severe twin-to-twin transfusion syndrome: a new sonographic feature of the placenta. (9286028)
1997
43
Twin-to-twin transfusion syndrome: aggressive therapeutic amniocentesis. (9290449)
1997
44
Twin-to-twin transfusion syndrome. (8757596)
1996
45
Twin-to-twin transfusion syndrome type III--case report of an intrauterine death in monochorionic pregnancy. (7653204)
1995
46
Diagnosis, pathophysiology, and treatment of chronic twin-to-twin transfusion syndrome. (7818775)
1994
47
Intrauterine death of co-twin in the third trimester: a case report of twin-to-twin transfusion syndrome and cord accident. (7904506)
1993
48
Ultrasonography and Doppler studies in twin-to-twin transfusion syndrome. (1492805)
1992
49
Sinusoidal fetal heart rate pattern associated with the twin to twin transfusion syndrome. (1968022)
1990
50
Diagnosis of twin to twin transfusion syndrome at 18 weeks of gestation. (6417174)
1983

Genetic Variations for Twin-to-Twin Transfusion Syndrome

About this section

Expression for genes affiliated with Twin-to-Twin Transfusion Syndrome

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Twin-to-Twin Transfusion Syndrome

Search GEO for disease gene expression data for Twin-to-Twin Transfusion Syndrome.

Pathways for genes affiliated with Twin-to-Twin Transfusion Syndrome

About this section
Sources:
29KEGG, 53Reactome, 51QIAGEN, 12EMD Millipore, 37NCBI BioSystems Database, 49PharmGKB, 55SinoBiological, 4Cell Signaling Technology
See all sources

Pathways related to Twin-to-Twin Transfusion Syndrome according to GeneCards/GeneDecks:

(show all 23)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1ANGPT1
210.0HIF1A
3
Hide members
9.8CST3, NPPA, B2M
4
Hide members
9.7PGF, REN
5
Hide members
9.5ALB, VEGFC, VEGFA
6
Development Leptin signaling via JAK/STAT and MAPK cascades
Hide members
9.5EDN1, VEGFA, HIF1A
79.5HIF1A, VEGFA, EDN1
89.4HIF1A, VEGFC, EDN1
9
Hide members
9.1VEGFA, VEGFC, ANGPT1, ANGPT2
10
Hide members
9.0FLT1, VEGFC, ANGPT1, ANGPT2
118.9FLT1, VEGFA, ANGPT1, HIF1A
12
Hide members
8.9PGF, VEGFC, VEGFA, FLT1
13
Hide members
8.9PGF, VEGFC, VEGFA, FLT1
14
Hide members
8.9FLT1, VEGFA, VEGFC, PGF
15
Hide members
8.9FLT1, VEGFA, VEGFC, PGF
168.7REN, HIF1A, ANGPT2, VEGFC, FLT1
17
Hide members
8.5FLT1, VEGFC, ANGPT1, ANGPT2, PGF
18
Hide members
8.5FLT1, VEGFC, ANGPT1, ANGPT2, PGF
19
Hide members
8.5FLT1, VEGFC, ANGPT1, ANGPT2, PGF
20
Hide members
8.4FLT1, VEGFA, VEGFC, HIF1A, PGF
218.2FLT1, VEGFA, VEGFC, ANGPT1, ANGPT2, PGF
228.1HIF1A, NPPA, EDN1, FLT1, VEGFA, ANGPT1
23
Hide members
8.0FLT1, VEGFC, ANGPT1, ANGPT2, HIF1A, PGF

Compounds for genes affiliated with Twin-to-Twin Transfusion Syndrome

About this section
Sources:
44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience
See all sources

Compounds related to Twin-to-Twin Transfusion Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 151)
idCompoundScoreTop Affiliating Genes
1mannitol44 1111.4ALB
2toki-shakuyaku-san4410.1EDN1, NPPA, REN
3uric acid44 2411.1CST3, AFP, B2M
4pge24410.0REN, VEGFC, VEGFA
5p-aminohippuric acid4410.0NPPA, ALB, B2M
6ramipril44 1110.9CST3, REN, ALB, NPPA
7urodilatin449.9EDN1, NPPA, REN
8lisinopril44 11 2411.8REN, ALB, NPPA, VEGFA
9perindopril44 49 1111.8VEGFA, ALB, NPPA, REN
10omapatrilat449.8REN, EDN1, NPPA
11carvedilol44 49 28 1112.7VEGFA, EDN1, NPPA, REN
1251-cr-edta449.7ALB, CST3, NPPA, B2M, REN
13sodium44 2410.7AMBP, AFP, REN, EDN1
14cilazapril44 1110.7EDN1, REN, NPPA
15iohexol449.6CST3, B2M, ALB, AMBP
16candesartan44 28 1111.5HIF1A, REN, ALB, VEGFA
17ang ii449.5NPPA, VEGFA, EDN1, REN
18potassium44 11 2411.5REN, ANGPT1, AFP, AMBP
19digoxin44 49 59 11 2413.5NPPA, HIF1A, CST3, REN
20trandolapril44 1110.5NPPA, REN, EDN1
21nitroglycerin44 1110.4EDN1, B2M, NPPA, REN, HIF1A
22captopril44 28 49 59 1113.4REN, B2M, ALB, CST3, EDN1, NPPA
23hanp449.4EDN1, NPPA, AMBP, B2M, REN
24kininogen449.4ALB, REN, NPPA, AMBP, CST3
25enalapril44 49 1111.4AMBP, NPPA, EDN1, REN, ALB
26sodium nitroprusside449.3NPPA, EDN1, B2M, HIF1A, REN
27celecoxib44 59 28 49 11 2414.3ALB, REN, HIF1A, ANGPT2, VEGFA
28urea44 11 2411.2AMBP, AFP, B2M, CST3, ALB
29inulin449.2AMBP, CST3, NPPA, B2M, REN, ALB
30nifedipine44 49 28 1112.2EDN1, B2M, AMBP, REN, NPPA
31matrigel449.1FLT1, HIF1A, ANGPT1, PGF
32sunitinib44 49 1111.1PGF, HIF1A, VEGFA, FLT1
33fibrinogen448.7AMBP, AFP, ANGPT1, ANGPT2, ALB, CST3
34glyceraldehyde 3-phosphate448.7B2M, FLT1, HIF1A, ANGPT2, ANGPT1, VEGFC
35oxygen44 249.7ANGPT2, ANGPT1, VEGFC, AFP, PGF, FLT1
36prostacyclin448.6VEGFA, ANGPT1, FLT1, EDN1, NPPA, PGF
37cyclosporin a44 28 5910.5ANGPT2, EDN1, B2M, ANGPT1, HIF1A, AMBP
38heparin44 28 11 2411.5AFP, VEGFA, PGF, FLT1, PAPPA
39doxorubicin44 49 1110.4HIF1A, FLT1, ANGPT1, AFP, VEGFA, B2M
40cisplatin44 49 59 1111.4HIF1A, CST3, B2M, AFP, VEGFA, AMBP
41thymidine44 249.2VEGFC, HIF1A, FLT1, EDN1, ANGPT2, B2M
42dexamethasone44 49 28 1111.1HIF1A, PAPPA, REN, AFP, VEGFA, VEGFC
43steroid447.8B2M, REN, ANGPT1, AMBP, AFP, ANGPT2
44nitric oxide44 11 249.7EDN1, HIF1A, FLT1, ANGPT1, ANGPT2, REN
45paraffin447.7FLT1, AFP, B2M, HIF1A, VEGFA, VEGFC
46creatinine447.7AMBP, CST3, NPPA, FLT1, AFP, ANGPT2
47lipid447.0ALB, AMBP, CST3, AFP, VEGFC, PGF
48glucose446.7FLT1, AMBP, PAPPA, PGF, REN, CST3
49vegf445.9PAPPA, FLT1, AFP, EDN1, NPPA, CST3
50calcium44 49 11 248.9CST3, AMBP, NPPA, B2M, VEGFC, EDN1

GO Terms for genes affiliated with Twin-to-Twin Transfusion Syndrome

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Twin-to-Twin Transfusion Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.5ALB, VEGFC, VEGFA
2extracellular regionGO:0055765.5AMBP, CST3, NPPA, EDN1, B2M, VEGFA
3extracellular spaceGO:0056155.0ALB, AMBP, CST3, NPPA, EDN1, FLT1

Biological processes related to Twin-to-Twin Transfusion Syndrome according to GeneCards/GeneDecks:

(show all 27)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of chemokine-mediated signaling pathwayGO:07010110.1EDN1, HIF1A
2glomerulus vasculature developmentGO:07201210.1ANGPT1, ANGPT2
3positive regulation of mast cell chemotaxisGO:06075410.1VEGFC, VEGFA
4Tie signaling pathwayGO:04801410.1ANGPT1, ANGPT2
5positive regulation of transcription from RNA polymerase II promoter in response to hypoxiaGO:06141910.0VEGFA, HIF1A
6positive regulation of endothelial cell migrationGO:0105959.9ANGPT1, VEGFA, EDN1
7positive regulation of receptor biosynthetic processGO:0108709.8HIF1A, EDN1
8induction of positive chemotaxisGO:0509309.8VEGFC, VEGFA
9patterning of blood vesselsGO:0015699.8EDN1, FLT1, VEGFA
10positive regulation of blood vessel endothelial cell migrationGO:0435369.8VEGFA, VEGFC, ANGPT1
11positive chemotaxisGO:0509189.8ANGPT1, VEGFC, VEGFA
12positive regulation of MAP kinase activityGO:0434069.8VEGFA, FLT1, EDN1
13positive regulation of protein autophosphorylationGO:0319549.7VEGFC, VEGFA
14positive regulation of neuroblast proliferationGO:0020529.7HIF1A, VEGFC, VEGFA
15positive regulation of vascular endothelial growth factor receptor signaling pathwayGO:0309499.7HIF1A, VEGFA, FLT1
16platelet degranulationGO:0025769.5VEGFA, VEGFC, ALB
17positive regulation of cell divisionGO:0517819.5VEGFA, VEGFC, PGF
18sprouting angiogenesisGO:0020409.5FLT1, ANGPT1, PGF
19dopaminergic neuron differentiationGO:0715429.4HIF1A, VEGFA
20positive regulation of endothelial cell proliferationGO:0019389.4PGF, HIF1A, VEGFA
21vascular endothelial growth factor receptor signaling pathwayGO:0480109.3PGF, VEGFC, VEGFA, FLT1
22angiogenesisGO:0015259.2VEGFA, VEGFC, ANGPT2, HIF1A
23response to hypoxiaGO:0016669.0EDN1, VEGFA, ANGPT2, HIF1A, PGF
24blood coagulationGO:0075969.0VEGFA, VEGFC, ANGPT1, ANGPT2, ALB
25positive regulation of cell proliferationGO:0082848.8EDN1, FLT1, VEGFA, VEGFC, PGF
26positive regulation of angiogenesisGO:0457668.8FLT1, VEGFA, ANGPT2, HIF1A, PGF
27female pregnancyGO:0075658.7AMBP, NPPA, PGF, PAPPA

Products for genes affiliated with Twin-to-Twin Transfusion Syndrome

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Twin-to-Twin Transfusion Syndrome

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet