MCID: TWN001
MIFTS: 58

Twin-to-Twin Transfusion Syndrome malady

Blood diseases category

Summaries for Twin-to-Twin Transfusion Syndrome

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63Wikipedia, 32MalaCards
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Wikipedia:63 Twin-to-twin transfusion syndrome (TTTS, also known as Feto-Fetal Transfusion Syndrome (FFTS) and Twin... more...

MalaCards: Twin-to-Twin Transfusion Syndrome, also known as fetal blood loss from fetal hemorrhage into co-twin, is related to polyhydramnios and polycythemia. An important gene associated with Twin-to-Twin Transfusion Syndrome is ASPRV1 (aspartic peptidase, retroviral-like 1), and among its related pathways are Rheumatoid arthritis and Pathways in cancer. The compounds mannitol and toki-shakuyaku-san have been mentioned in the context of this disorder. Affiliated tissues include placenta, heart and brain, and related mouse phenotypes are renal/urinary system and embryogenesis.

Aliases & Classifications for Twin-to-Twin Transfusion Syndrome

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8Disease Ontology, 10DISEASES, 48Orphanet, 60UMLS, 56SNOMED-CT, 34MeSH, 57SNOMED-CT via Orphanet, 26ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Blood diseases


Aliases & Descriptions:

twin-to-twin transfusion syndrome 8 10
fetal blood loss from fetal hemorrhage into co-twin 8
ffts - fetofetal transfusion syndrome 60
twin to twin transfusion syndrome 48
feto-fetal transfusion syndrome 48
fetal hemorrhage into co-twin 8
twin-to-twin blood transfer 8
twin to twin transfusion 8


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Disease Ontology8 DOID:13576
MeSH34 D005330
SNOMED-CT via Orphanet57 13404009
ICD10 via Orphanet26 O43.0

Related Diseases for Twin-to-Twin Transfusion Syndrome

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17GeneCards, 18GeneDecks
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Diseases in the Twin-to-Twin Transfusion Syndrome family:

Twin Twin Transfusion Syndrome

Diseases related to Twin-to-Twin Transfusion Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 184)
idRelated DiseaseScoreTop Affiliating Genes
1polyhydramnios30.7AFP
2polycythemia30.6HIF1A
3oligohydramnios30.4AFP
4pulmonary embolism30.4ALB
5peritonitis30.4ALB, B2M
6down syndrome30.4PGF, PAPPA, AFP
7hypertension30.4CST3, NPPA, EDN1, REN, ALB, PGF
8myocardial infarction30.4CST3, NPPA, ANGPT1, HIF1A, REN, PGF
9ischemia30.3PGF, ANGPT1, VEGFC, VEGFA, EDN1, FLT1
10cerebritis10.6
11cervicitis10.5
12twin twin transfusion syndrome10.5
13n syndrome10.4
14image syndrome10.4
15arteriovenous fistula10.3
16arteriovenous malformation10.3
17adult syndrome10.3
18cerebral palsy10.3
19hyperaldosteronism10.3
20gingivitis10.0CST3
21hepatitis10.0AFP
22hypothyroidism10.0CST3
23cerebrovascular disease10.0CST3
24amyotrophic lateral sclerosis10.0CST3
25vesicoureteral reflux10.0AMBP
26multiple myeloma10.0B2M
27gastroschisis10.0AFP
28galactosemia10.0ALB
29portal vein thrombosis10.0AFP
30vasculitis10.0ALB
31glaucoma10.0EDN1
32congenital heart defect10.0NPPA
33pancreatitis10.0ALB
34viral hepatitis10.0AFP
35neuropathy10.0ALB
36meningitis10.0ALB
37hepatitis e10.0AMBP
38kidney cancer10.0VEGFA
39pulmonary fibrosis10.0EDN1
40crohn's disease10.0ALB
41brain edema10.0ALB
42blindness10.0VEGFA
43lupus nephritis10.0ALB
44cholestasis10.0ALB
45hyperparathyroidism10.0ALB
46rhinitis10.0ALB
47hypoaldosteronism10.0REN
48poems syndrome10.0VEGFA
49chondrosarcoma10.0AMBP
50varicose veins10.0ALB

Graphical network of the top 20 diseases related to Twin-to-Twin Transfusion Syndrome:



Diseases related to twin-to-twin transfusion syndrome

Clinical Features for Twin-to-Twin Transfusion Syndrome

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Drugs & Therapeutics for Twin-to-Twin Transfusion Syndrome

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Twin-to-Twin Transfusion Syndrome

Search CenterWatch for Twin-to-Twin Transfusion Syndrome

Genetic Tests for Twin-to-Twin Transfusion Syndrome

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Anatomical Context for Twin-to-Twin Transfusion Syndrome

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32MalaCards
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MalaCards organs/tissues related to Twin-to-Twin Transfusion Syndrome:

32
Placenta, Heart, Brain, Eye, Bone, Liver, Cervix

Animal Models for Twin-to-Twin Transfusion Syndrome or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Twin-to-Twin Transfusion Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053679.2EDN1, ANGPT1, HIF1A, REN
2MP:00053809.1AMBP, EDN1, PGF
3MP:00053698.7CST3, NPPA, FLT1, ANGPT1, HIF1A, REN
4MP:00053768.7CST3, NPPA, B2M, AFP, REN, PGF
5MP:00053818.6ALB, HIF1A, ANGPT2, VEGFA, B2M, EDN1
6MP:00020068.3CST3, B2M, AFP, VEGFA, HIF1A, PGF
7MP:00028737.6EDN1, FLT1, VEGFA, HIF1A, REN, ALB
8MP:00107687.0EDN1, FLT1, B2M, AFP, VEGFA, VEGFC
9MP:00053856.9ADD3, CST3, NPPA, EDN1, FLT1, B2M

Publications for Twin-to-Twin Transfusion Syndrome

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50PubMed
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Articles related to Twin-to-Twin Transfusion Syndrome:

(show top 50)    (show all 230)
idTitleAuthorsYear
1
Maternal Perception of Decreased Fetal Movement in One Twin: A Clue Leading to the Early Detection of Absent Variability due to Acute Twin-to-Twin Transfusion Syndrome. (23984131)
2013
2
Twin-to-twin transfusion syndrome: a case study. (23360857)
2013
3
Neonatal urinary ascites complicated by ileal perforation in a recipient of twin-to-twin transfusion syndrome. (23255026)
2013
4
Evaluation of the measurement of the middle cerebral artery peak systolic velocity before and after placental laser coagulation in twin-to-twin transfusion syndrome. (22418955)
2012
5
Timing of delivery following selective laser photocoagulation for twin-to-twin transfusion syndrome. (22840722)
2012
6
Laser therapy for twin-to-twin transfusion syndrome causing amniotic band syndrome. (21037281)
2011
7
Twin-to-twin transfusion syndrome (TTTS). (21142846)
2011
8
Management of Stage I twin-to-twin transfusion syndrome: an international survey. (20104530)
2010
9
Preoperative predictors of death in twin-to-twin transfusion syndrome treated with laser ablation of placental anastomoses. (20691964)
2010
10
Changes in umbilical venous volume flow after fetoscopic laser occlusion of placental vascular anastomoses in twin-to-twin transfusion syndrome. (20864074)
2010
11
A trend toward increased first trimester free beta-hCG and PAPP-A in monochorionic twins complicated by Twin-to-Twin Transfusion syndrome. (20715121)
2010
12
Intestinal complications after antenatal fetoscopic laser ablation in twin-to-twin transfusion syndrome. (20105572)
2010
13
Very early twin-to-twin transfusion syndrome and discordant activation of the renin-angiotensin system. (19577294)
2009
14
A case of successful selective abortion using radio-frequency ablation in twin pregnancy suffering from severe twin to twin transfusion syndrome. (19543519)
2009
15
Recipient's vascular doppler pattern immediately following death of the donor in a case of untreated severe twin-to-twin transfusion syndrome. (18648206)
2008
16
Power and interpretation of a randomized study on the treatment of severe twin-to-twin transfusion syndrome. (18455548)
2008
17
Necrotizing enterocolitis in premature twins with twin-to-twin transfusion syndrome. (18302071)
2008
18
Septostomy with amniodrainage in the treatment of twin-to-twin transfusion syndrome: a 16-case report. (17072630)
2007
19
Twin-to-twin transfusion syndrome. (17574256)
2007
20
Twin-to-twin transfusion syndrome: time to forget the Quintero staging system? (18044824)
2007
21
Maternal pseudo primary hyperaldosteronism in twin-to-twin transfusion syndrome. (17233862)
2007
22
Incidence, mechanisms, and patterns of fetal cerebral lesions in twin-to-twin transfusion syndrome. (17674276)
2007
23
Twin-to-twin transfusion syndrome: is the future getting brighter? (17550480)
2007
24
Long-term neurodevelopmental outcome in twin-to-twin transfusion syndrome treated with fetoscopic laser surgery. (17346532)
2007
25
Risk of persistent pulmonary hypertension of the neonate in twin-to-twin transfusion syndrome. (17396038)
2007
26
Intrauterine fetal demise following laser treatment in twin-to-twin transfusion syndrome. (16579799)
2006
27
Monochorionic diamniotic infants without twin-to-twin transfusion syndrome. (16281049)
2005
28
The long term neurologic outcome of children from pregnancies complicated by twin-to-twin transfusion syndrome. (15663399)
2005
29
What--and why--the pediatric surgeon should know about twin-to-twin transfusion syndrome. (16034746)
2005
30
Twin-to-twin transfusion syndrome. (16480236)
2005
31
Neonatal outcome in twin-to-twin transfusion syndrome treated with fetoscopic laser occlusion of vascular anastomoses. (16291348)
2005
32
Ileal atresia and thrombo-embolic liver calcifications diagnosed after treatment with intrauterine laser coagulation therapy for twin-to-twin transfusion syndrome: report of 2 cases. (15937836)
2005
33
Prenatal cardiovascular manifestations in the twin-to-twin transfusion syndrome recipients and the impact of therapeutic amnioreduction. (15746688)
2005
34
Minimal-access fetal surgery for twin-to-twin transfusion syndrome. (14625725)
2004
35
Pulmonary artery calcification in recipient twins of twin to twin transfusion syndrome: a report of three cases. (12574984)
2003
36
Congenital bowel perforation in twin-to-twin transfusion syndrome. (12598976)
2002
37
First trimester twin-to-twin transfusion syndrome in a trichorionic quadruplet pregnancy--a diagnostic challenge. (12393966)
2002
38
Use of continuous fluid drainage for severe polyhydramnios due to twin to twin transfusion syndrome. (11491373)
2001
39
Outcome for children born after in utero laser ablation therapy for severe twin-to-twin transfusion syndrome. (11843386)
2001
40
Twin-to-twin transfusion syndrome--debates on the etiology, natural history and management. (11169283)
2000
41
Cardiovascular sequelae of fetal twin-to-twin transfusion syndrome: an echocardiographic perspective. (10397442)
1999
42
Twin-to-twin transfusion syndrome with hydrops: a retrospective analysis of ten cases. (10586978)
1999
43
Twin-to-twin transfusion syndrome: polyhydramnios-associated changes in maternal plasma volume and maternal plasma aldosterone concentrations. A preliminary study. (9708444)
1998
44
Increased nuchal translucency thickness at 10-14 weeks of gestation as a predictor of severe twin-to-twin transfusion syndrome. (9286014)
1997
45
Lenticulostriate vasculopathy in twin-to-twin transfusion syndrome: sonographic and CT findings. (8577550)
1995
46
Twin-to-twin transfusion syndrome: selective feticide by embolization of the hydropic fetus. (7710677)
1995
47
Temporary iatrogenic fetal tricuspid valve atresia in a case of twin to twin transfusion syndrome. (7818963)
1994
48
The value of Doppler ultrasound in the diagnosis and management of twin-to-twin transfusion syndrome. (8042877)
1994
49
Paradoxical bone mineralisation in the twin to twin transfusion syndrome. (2386404)
1990
50
Severe cervical stenosis with the twin-to-twin transfusion syndrome. (3393959)
1988

Genetic Variations for Twin-to-Twin Transfusion Syndrome

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Expression for genes affiliated with Twin-to-Twin Transfusion Syndrome

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Twin-to-Twin Transfusion Syndrome

Search GEO for disease gene expression data for Twin-to-Twin Transfusion Syndrome.

Pathways for genes affiliated with Twin-to-Twin Transfusion Syndrome

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Sources:
29KEGG, 53Reactome, 51QIAGEN, 12EMD Millipore, 37NCBI BioSystems Database, 49PharmGKB, 55SinoBiological, 4Cell Signaling Technology
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Pathways related to Twin-to-Twin Transfusion Syndrome according to GeneCards/GeneDecks:

(show all 23)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1ANGPT1
210.0HIF1A
3
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9.8CST3, B2M, NPPA
4
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9.7PGF, REN
5
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9.5VEGFA, VEGFC, ALB
6
Development Leptin signaling via JAK/STAT and MAPK cascades
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9.5VEGFA, HIF1A, EDN1
79.5EDN1, HIF1A, VEGFA
89.4EDN1, HIF1A, VEGFC
9
Hide members
9.1ANGPT2, ANGPT1, VEGFC, VEGFA
10
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9.0VEGFC, ANGPT1, ANGPT2, FLT1
118.9HIF1A, ANGPT1, VEGFA, FLT1
12
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8.9VEGFC, FLT1, VEGFA, PGF
13
Hide members
8.9FLT1, VEGFA, VEGFC, PGF
14
Hide members
8.9VEGFA, FLT1, VEGFC, PGF
15
Hide members
8.9PGF, FLT1, VEGFA, VEGFC
168.7REN, HIF1A, ANGPT2, VEGFC, FLT1
17
Hide members
8.5VEGFC, PGF, ANGPT2, ANGPT1, FLT1
18
Hide members
8.5FLT1, VEGFC, ANGPT1, ANGPT2, PGF
19
Hide members
8.5FLT1, VEGFC, PGF, ANGPT2, ANGPT1
20
Hide members
8.4FLT1, PGF, VEGFA, VEGFC, HIF1A
218.2PGF, ANGPT2, ANGPT1, VEGFC, FLT1, VEGFA
228.1VEGFA, HIF1A, ANGPT2, ANGPT1, FLT1, EDN1
23
Hide members
8.0FLT1, VEGFC, ANGPT1, ANGPT2, HIF1A, PGF

Compounds for genes affiliated with Twin-to-Twin Transfusion Syndrome

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44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Twin-to-Twin Transfusion Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 151)
idCompoundScoreTop Affiliating Genes
1mannitol44 1111.4ALB
2toki-shakuyaku-san4410.1EDN1, NPPA, REN
3uric acid44 2411.1CST3, AFP, B2M
4pge24410.0REN, VEGFC, VEGFA
5p-aminohippuric acid4410.0NPPA, ALB, B2M
6ramipril44 1110.9CST3, REN, ALB, NPPA
7urodilatin449.9EDN1, NPPA, REN
8lisinopril44 11 2411.8REN, ALB, NPPA, VEGFA
9perindopril44 49 1111.8VEGFA, ALB, NPPA, REN
10omapatrilat449.8REN, EDN1, NPPA
11carvedilol44 49 28 1112.7VEGFA, EDN1, NPPA, REN
1251-cr-edta449.7ALB, CST3, NPPA, B2M, REN
13sodium44 2410.7AMBP, AFP, REN, EDN1
14cilazapril44 1110.7EDN1, REN, NPPA
15iohexol449.6CST3, B2M, ALB, AMBP
16candesartan44 28 1111.5HIF1A, REN, ALB, VEGFA
17ang ii449.5NPPA, VEGFA, EDN1, REN
18potassium44 11 2411.5REN, ANGPT1, AFP, AMBP
19digoxin44 49 59 11 2413.5NPPA, HIF1A, CST3, REN
20trandolapril44 1110.5NPPA, REN, EDN1
21nitroglycerin44 1110.4EDN1, B2M, NPPA, REN, HIF1A
22captopril44 28 49 59 1113.4REN, B2M, ALB, CST3, EDN1, NPPA
23hanp449.4EDN1, NPPA, AMBP, B2M, REN
24kininogen449.4ALB, REN, NPPA, AMBP, CST3
25enalapril44 49 1111.4AMBP, NPPA, EDN1, REN, ALB
26sodium nitroprusside449.3NPPA, EDN1, B2M, HIF1A, REN
27celecoxib44 59 28 49 11 2414.3ALB, REN, HIF1A, ANGPT2, VEGFA
28urea44 11 2411.2AMBP, AFP, B2M, CST3, ALB
29inulin449.2AMBP, CST3, NPPA, B2M, REN, ALB
30nifedipine44 49 28 1112.2EDN1, B2M, AMBP, REN, NPPA
31matrigel449.1FLT1, HIF1A, ANGPT1, PGF
32sunitinib44 49 1111.1PGF, HIF1A, VEGFA, FLT1
33fibrinogen448.7AMBP, AFP, ANGPT1, ANGPT2, ALB, CST3
34glyceraldehyde 3-phosphate448.7B2M, FLT1, HIF1A, ANGPT2, ANGPT1, VEGFC
35oxygen44 249.7ANGPT2, ANGPT1, VEGFC, AFP, PGF, FLT1
36prostacyclin448.6VEGFA, ANGPT1, FLT1, EDN1, NPPA, PGF
37cyclosporin a44 28 5910.5ANGPT2, EDN1, B2M, ANGPT1, HIF1A, AMBP
38heparin44 28 11 2411.5AFP, VEGFA, PGF, FLT1, PAPPA
39doxorubicin44 49 1110.4HIF1A, FLT1, ANGPT1, AFP, VEGFA, B2M
40cisplatin44 49 59 1111.4HIF1A, CST3, B2M, AFP, VEGFA, AMBP
41thymidine44 249.2VEGFC, HIF1A, FLT1, EDN1, ANGPT2, B2M
42dexamethasone44 49 28 1111.1HIF1A, PAPPA, REN, AFP, VEGFA, VEGFC
43steroid447.8B2M, REN, ANGPT1, AMBP, AFP, ANGPT2
44nitric oxide44 11 249.7EDN1, HIF1A, FLT1, ANGPT1, ANGPT2, REN
45paraffin447.7FLT1, AFP, B2M, HIF1A, VEGFA, VEGFC
46creatinine447.7AMBP, CST3, NPPA, FLT1, AFP, ANGPT2
47lipid447.0ALB, AMBP, CST3, AFP, VEGFC, PGF
48glucose446.7FLT1, AMBP, PAPPA, PGF, REN, CST3
49vegf445.9PAPPA, FLT1, AFP, EDN1, NPPA, CST3
50calcium44 49 11 248.9CST3, AMBP, NPPA, B2M, VEGFC, EDN1

GO Terms for genes affiliated with Twin-to-Twin Transfusion Syndrome

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16Gene Ontology
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Cellular components related to Twin-to-Twin Transfusion Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.5ALB, VEGFC, VEGFA
2extracellular regionGO:0055765.5ALB, AMBP, PAPPA, PGF, REN, ANGPT2
3extracellular spaceGO:0056155.0PGF, ALB, REN, ANGPT2, ANGPT1, VEGFC

Biological processes related to Twin-to-Twin Transfusion Syndrome according to GeneCards/GeneDecks:

(show all 27)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of chemokine-mediated signaling pathwayGO:07010110.1EDN1, HIF1A
2glomerulus vasculature developmentGO:07201210.1ANGPT1, ANGPT2
3positive regulation of mast cell chemotaxisGO:06075410.1VEGFC, VEGFA
4Tie signaling pathwayGO:04801410.1ANGPT1, ANGPT2
5positive regulation of transcription from RNA polymerase II promoter in response to hypoxiaGO:06141910.0VEGFA, HIF1A
6positive regulation of endothelial cell migrationGO:0105959.9ANGPT1, VEGFA, EDN1
7positive regulation of receptor biosynthetic processGO:0108709.8HIF1A, EDN1
8induction of positive chemotaxisGO:0509309.8VEGFC, VEGFA
9patterning of blood vesselsGO:0015699.8EDN1, FLT1, VEGFA
10positive regulation of blood vessel endothelial cell migrationGO:0435369.8VEGFA, VEGFC, ANGPT1
11positive chemotaxisGO:0509189.8ANGPT1, VEGFC, VEGFA
12positive regulation of MAP kinase activityGO:0434069.8VEGFA, FLT1, EDN1
13positive regulation of protein autophosphorylationGO:0319549.7VEGFC, VEGFA
14positive regulation of neuroblast proliferationGO:0020529.7HIF1A, VEGFC, VEGFA
15positive regulation of vascular endothelial growth factor receptor signaling pathwayGO:0309499.7HIF1A, VEGFA, FLT1
16platelet degranulationGO:0025769.5VEGFA, VEGFC, ALB
17positive regulation of cell divisionGO:0517819.5VEGFA, VEGFC, PGF
18sprouting angiogenesisGO:0020409.5FLT1, ANGPT1, PGF
19dopaminergic neuron differentiationGO:0715429.4HIF1A, VEGFA
20positive regulation of endothelial cell proliferationGO:0019389.4PGF, HIF1A, VEGFA
21vascular endothelial growth factor receptor signaling pathwayGO:0480109.3PGF, VEGFC, VEGFA, FLT1
22angiogenesisGO:0015259.2VEGFA, VEGFC, ANGPT2, HIF1A
23response to hypoxiaGO:0016669.0EDN1, VEGFA, ANGPT2, HIF1A, PGF
24blood coagulationGO:0075969.0VEGFA, VEGFC, ANGPT1, ANGPT2, ALB
25positive regulation of cell proliferationGO:0082848.8EDN1, FLT1, VEGFA, VEGFC, PGF
26positive regulation of angiogenesisGO:0457668.8FLT1, VEGFA, ANGPT2, HIF1A, PGF
27female pregnancyGO:0075658.7AMBP, NPPA, PGF, PAPPA

Products for genes affiliated with Twin-to-Twin Transfusion Syndrome

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Sources for Twin-to-Twin Transfusion Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet