MCID: TWN001
MIFTS: 46

Twin-to-Twin Transfusion Syndrome

Categories: Rare diseases, Blood diseases, Fetal diseases

Aliases & Classifications for Twin-to-Twin Transfusion Syndrome

MalaCards integrated aliases for Twin-to-Twin Transfusion Syndrome:

Name: Twin-to-Twin Transfusion Syndrome 39 12 50 14
Twin to Twin Transfusion Syndrome 50 56
Fetal Blood Loss from Fetal Hemorrhage into Co-Twin 12
Fetus-to-Fetus Placental Transfusion Syndrome 69
Feto-Fetal Transfusion Syndrome 56
Twin Twin Transfusion Syndrome 39
Fetofetal Transfusion Syndrome 50
Fetal Hemorrhage into Co-Twin 12
Twin-to-Twin Blood Transfer 12
Fetal Transfusion Syndrome 50
Twin to Twin Transfusion 12
Fetofetal Transfusion 42
Ttts 50

Classifications:



External Ids:

Disease Ontology 12 DOID:13576
ICD10 33 O43.02 O43.029
MeSH 42 D005330
NCIt 47 C113824
SNOMED-CT 64 13404009 237299001
Orphanet 56 ORPHA95431
ICD10 via Orphanet 34 O43.0
UMLS 69 C2909036

Summaries for Twin-to-Twin Transfusion Syndrome

NIH Rare Diseases : 50 twin to twin transfusion syndrome (ttts) is a rare condition that occurs during a twin pregnancy when blood moves from one twin (the “donor twin”) to the other (the “recipient twin”) while in the womb. ttts is a complication that specifically occurs in identical (monozygotic) twin pregnancies that share the same "egg" sac (monochorionic) that may or may not share the same amniotic sac (monoamniotic). ttts usually develops between 15 and 26 weeks of pregnancy. the donor twin may be born smaller, with paleness, anemia, and dehydration. the recipient twin may be born larger, with redness, too much blood, and increased blood pressure, resulting in an increased risk for heart failure. treatment may require repeated amniocentesis during pregnancy. fetal laser surgery may be done to interrupt the flow of blood from one twin to the other. after birth, treatment depends on the infant's specific symptoms. the donor twin may need a blood transfusion to treat anemia. the recipient twin may need to have the volume of body fluid reduced. this may involve an exchange transfusion. medications may be given to treat heart failure in the recipient twin. last updated: 7/21/2016

MalaCards based summary : Twin-to-Twin Transfusion Syndrome, also known as twin to twin transfusion syndrome, is related to renal tubular dysgenesis and acitretin/etretinate embryopathy. An important gene associated with Twin-to-Twin Transfusion Syndrome is PGF (Placental Growth Factor), and among its related pathways/superpathways are ERK Signaling and TGF-Beta Pathway. The drugs Progesterone and Progestins have been mentioned in the context of this disorder. Affiliated tissues include heart, placenta and cervix, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 72 Twin-to-twin transfusion syndrome (TTTS), also known as Feto-Fetal Transfusion Syndrome (FFTS) and Twin... more...

Related Diseases for Twin-to-Twin Transfusion Syndrome

Diseases related to Twin-to-Twin Transfusion Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 51)
id Related Disease Score Top Affiliating Genes
1 renal tubular dysgenesis 11.4
2 acitretin/etretinate embryopathy 10.4 FLT1 PGF
3 salivary gland adenoid cystic carcinoma 10.3 ENG FLT1
4 idiopathic progressive polyneuropathy 10.3 FLT1 PGF
5 coloboma of superior eyelid 10.3 FLT1 PGF
6 mitral valve stenosis 10.2 ENG FLT1
7 cerebritis 10.2
8 cervicitis 10.1
9 heart disease 10.1
10 polycythemia 10.1
11 polyhydramnios 10.1
12 ulcerative stomatitis 10.1 ENG FLT1 PGF
13 preeclampsia/eclampsia 1 10.1 ENG FLT1 PGF
14 obstructive jaundice 10.0 ENG FLT1 PGF
15 acute proliferative glomerulonephritis 10.0 ENG FLT1 PGF
16 congenital cytomegalovirus 10.0
17 cytomegalovirus infection 10.0
18 pyruvate kinase deficiency, muscle type 10.0 ANGPT1 ANGPT2
19 renal fibrosis 10.0 ANGPT2 PGF
20 macular dystrophy, atypical vitelliform 10.0 ANGPT1 ANGPT2
21 polymicrogyria 9.9
22 hydranencephaly 9.9
23 neuropathy, hereditary sensory and autonomic, type vi 9.9 ANGPT2 FLT1
24 hidradenoma 9.9 ANGPT2 FLT1 PGF
25 arteriovenous fistula 9.8
26 cerebral palsy 9.8
27 amniotic band syndrome 9.8
28 limb ischemia 9.8
29 arteriovenous malformation 9.8
30 hydrops fetalis 9.8
31 transposition of the great arteries 9.8
32 oligohydramnios 9.8
33 post-traumatic stress disorder 9.8
34 ischemia 9.8
35 hyperaldosteronism 9.8
36 myocardial infarction 9.8
37 peritonitis 9.8
38 down syndrome 9.8
39 pulmonary hypertension 9.8
40 pulmonary embolism 9.8
41 diabetes mellitus, insulin-dependent, 3 9.8 ANGPT1 ANGPT2
42 citrullinemia, adult-onset type ii 9.8 ANGPT2 FLT1 PGF
43 vernal conjunctivitis 9.8 ANGPT2 FLT1
44 hematopoietic stem cell transplantation 9.7 ANGPT1 ANGPT2
45 lipoic acid synthetase deficiency 9.7 ANGPT1 ANGPT2 FLT1
46 albinism, oculocutaneous, type ia 9.6 ANGPT1 ANGPT2 FLT1
47 pleural tuberculosis 9.6 ENG FLT1 PGF REN
48 holoprosencephaly 9.5 ANGPT2 ENG
49 lubani-al saleh-teebi syndrome 9.4 ANGPT1 ENG FLT1 REN
50 testicular leydig cell tumor 9.3 ANGPT1 ANGPT2 FLT1 PGF

Graphical network of the top 20 diseases related to Twin-to-Twin Transfusion Syndrome:



Diseases related to Twin-to-Twin Transfusion Syndrome

Symptoms & Phenotypes for Twin-to-Twin Transfusion Syndrome

MGI Mouse Phenotypes related to Twin-to-Twin Transfusion Syndrome:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.8 ANGPT1 ANGPT2 ENG FLT1 PGF REN
2 homeostasis/metabolism MP:0005376 9.7 VEGFC ANGPT1 ANGPT2 ENG FLT1 PGF
3 immune system MP:0005387 9.43 ANGPT1 ANGPT2 FLT1 PGF REN VEGFC
4 mortality/aging MP:0010768 9.17 ANGPT1 ANGPT2 ENG FLT1 REN TUBB3

Drugs & Therapeutics for Twin-to-Twin Transfusion Syndrome

Drugs for Twin-to-Twin Transfusion Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 27)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Progesterone Approved, Vet_approved Phase 3 57-83-0 5994
2 Progestins Phase 3
3 11-hydroxyprogesterone Phase 3
4 17-alpha-hydroxy-progesterone caproate Phase 3
5 Hormone Antagonists Phase 3
6 Hormones Phase 3
7 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
8 Estrogen Antagonists Phase 3
9 Estrogens Phase 3
10 Caproate Nutraceutical Phase 3
11
Epinephrine Approved, Vet_approved 51-43-4 5816
12
Lidocaine Approved, Vet_approved 137-58-6 3676
13 Racepinephrine Approved
14
Glucosamine Approved, Nutraceutical 3416-24-8 439213
15 Fibrinolytic Agents
16 Central Nervous System Depressants
17 Glucuronyl glucosamine glycan sulfate
18 Anesthetics
19 Anti-Bacterial Agents
20 Epinephryl borate
21 Hypoglycemic Agents
22 Hypolipidemic Agents
23 Anticoagulants
24 Lipid Regulating Agents
25 Antibiotics, Antitubercular
26 Antimetabolites
27 Anesthetics, Local

Interventional clinical trials:

(show all 15)

id Name Status NCT ID Phase Drugs
1 Randomized Controlled Trial Comparing a Conservative Management and Laser Surgery Recruiting NCT01220011 Phase 4
2 Trial of Progesterone in Twins and Triplets to Prevent Preterm Birth (STTARS) Completed NCT00099164 Phase 3 17 alpha-hydroxyprogesterone caproate (17P)
3 Fetoscopic Selective Laser Photocoagulation in Twin-Twin Transfusion Syndrome Unknown status NCT00345852
4 Selective Laser Photocoagulation of Communicating Vessels in Twin-Twin Transfusion Syndrome Completed NCT01622049
5 Anesthetic Management in Fetoscopic Surgery and Incidence of Complications Completed NCT02434926
6 Sequential vs. Standard Laser Treatment of Twin-twin Transfusion Syndrome Recruiting NCT02122328
7 The Utility of MRI Scoring to Predict Neurodevelopmental Outcomes in Survivors of Twin-to-Twin Transfusion Syndrome Recruiting NCT02249624
8 The Trial of Pessary After Laser for TTTS Recruiting NCT01334489
9 Neonatal Outcome for Laser Coagulation in Twin-to-twin-transfusion Syndrome Recruiting NCT03151915
10 Austrian Registry on the Outcome of Monochorionic Pregnancies Recruiting NCT03171909
11 Pessary to Prevent Prematurity in Twins in Case of Short Cervix Recruiting NCT02328989
12 Unequal Placental Sharing in Monochorionic Diamniotic Twins: an Observational Study Recruiting NCT03024918
13 Monochorial-diamniotic Pregnancies Complicated With a Twin-to-twin Syndrome Active, not recruiting NCT02611856
14 Laser Photocoagulation in Twin to Twin Transfusion Syndrome Enrolling by invitation NCT02506049
15 The Value of Prenatal Ultrasound in Complicated Twin Pregnancy and Its Correlation With Chromosomal Anomalies Not yet recruiting NCT02732717

Search NIH Clinical Center for Twin-to-Twin Transfusion Syndrome

Cochrane evidence based reviews: fetofetal transfusion

Genetic Tests for Twin-to-Twin Transfusion Syndrome

Anatomical Context for Twin-to-Twin Transfusion Syndrome

MalaCards organs/tissues related to Twin-to-Twin Transfusion Syndrome:

39
Heart, Placenta, Cervix, Brain, Liver, Bone, Eye

Publications for Twin-to-Twin Transfusion Syndrome

Articles related to Twin-to-Twin Transfusion Syndrome:

(show top 50) (show all 293)
id Title Authors Year
1
Fetoscopic laser coagulation in 1020 pregnancies with twin-to-twin transfusion syndrome demonstrates improvement of double survival rates. ( 28477345 )
2017
2
Virtual three-dimensional placentoscopy: a new approach to assess residual anastomoses following laser photocoagulation in twin-to-twin transfusion syndrome. ( 28114847 )
2017
3
Spontaneous resolution of mirror syndrome following fetal interventions for fetal anemia as a consequence of twin to twin transfusion syndrome. ( 27914652 )
2017
4
Arabin cervical pessary for prevention of preterm birth in cases of twin-to-twin transfusion syndrome treated by fetoscopic LASER coagulation: the PECEP LASER randomised controlled trial. ( 28764674 )
2017
5
Modified diagnostic criteria for twin-to-twin transfusion syndrome prior to 18 weeks' gestation: time to change? ( 28236371 )
2017
6
Doppler assessment of patients with twin-to-twin transfusion syndrome and survival following fetoscopic laser surgery. ( 28281301 )
2017
7
Aortic and pulmonary artery calcification: An unusual manifestation of twin-to-twin transfusion syndrome. ( 28163434 )
2017
8
Different patterns of left ventricular "rigid body rotation" in 8-year-old twins with anamnestic twin-to-twin transfusion syndrome (from the MAGYAR-Twin Study). ( 28275566 )
2017
9
Twin-to-Twin Transfusion Syndrome: Definition, Staging, and Ultrasound Assessment. ( 27203605 )
2016
10
Monochorionic diamniotic inA vitro fertilization twins have a decreased incidence of twin-to-twin transfusion syndrome. ( 26690011 )
2016
11
The History of Treatment of Twin-to-Twin Transfusion Syndrome. ( 27203604 )
2016
12
Twin-to-Twin Transfusion Syndrome: From Observational Evidence to Randomized Controlled Trials. ( 27075108 )
2016
13
Laser Treatment of Twin-to-Twin Transfusion Syndrome. ( 27203606 )
2016
14
Impact of Monochorionicity and Twin to Twin Transfusion Syndrome on Prenatal Attachment, Post Traumatic Stress Disorder, Anxiety and Depressive Symptoms. ( 26751570 )
2016
15
The 2016 Satellite Meeting of the International Society of Twin Studies: An Overview/Tribute to Irving I. Gottesman/Research: MZ Twinning After Single Embryo Transfer; Twin Study of Mononucleosis; Cerebral Injury After Twin-To-Twin Transfusion Syndrome Surgery/Human Interest: Sixteen Twin Pairs Born in a Single Hospital; Death of an Identical Twin Playwright; Twin Themes in Advertising; Conjoined Twins Separated in Saudi Arabia; Murder of One Twin By Her Co-Twin Disproved. ( 27524469 )
2016
16
Long-Term Neurodevelopmental Outcome in Survivors of Twin-to-Twin Transfusion Syndrome. ( 27137794 )
2016
17
Cardiac Manifestations of Twin-to-Twin Transfusion Syndrome. ( 27087122 )
2016
18
Early prediction of twin-to-twin transfusion syndrome: systematic review and meta-analysis. ( 27270878 )
2016
19
Fetal left modified myocardial performance index measured by the Auto Mod-MPI system: development of reference values and application to recipients of twin-to-twin transfusion syndrome. ( 26921842 )
2016
20
Increased Risk Of Early-Onset Neonatal Sepsis After Laser Surgery For Twin-to-Twin Transfusion Syndrome. ( 27137630 )
2016
21
Atypical twin-to-twin transfusion syndrome: prevalence inA aA populationA undergoing fetoscopic laser ablation of communicatingA placental vessels. ( 26827875 )
2016
22
A prospective pilot study of fetoscopic laser surgery for twin-to-twin transfusion syndrome between 26 and 27 weeks of gestation. ( 27590373 )
2016
23
Intra-arterial calcifications in the recipient twin in twin-to-twin transfusion syndrome. ( 27834168 )
2016
24
Evolution of Stage 1 Twin-to-Twin Transfusion Syndrome (TTTS): Systematic Review and Meta-Analysis. ( 27137946 )
2016
25
The Placenta in Twin-to-Twin Transfusion Syndrome and Twin Anemia Polycythemia Sequence. ( 27098457 )
2016
26
Identifying families' shared disease experiences through a qualitative analysis of online twin-to-twin transfusion syndrome stories. ( 27422614 )
2016
27
Fetoscopic laser photocoagulation in twin-to-twin transfusion syndrome: experience from a single institution. ( 27056209 )
2016
28
Balancing Patient Access to Fetoscopic Laser Photocoagulation for Twin-to-Twin Transfusion Syndrome With Maintaining Procedural Competence: Are Collaborative Services Part of the Solution? ( 27087260 )
2016
29
Future Directions in the Management of Twin-to-Twin Transfusion Syndrome. ( 27125296 )
2016
30
Longitudinal annular displacement by M-mode (MAPSE and TAPSE) in twin-to-twin transfusion syndrome before and after laser surgery. ( 26256442 )
2015
31
Pseudoamniotic Band Syndrome after In Utero Intervention for Twin-to-Twin Transfusion Syndrome: Case Reports and Literature Review. ( 25613236 )
2015
32
Transient twin reversed arterial perfusion: a protective effect in twin-to-twin transfusion syndrome? ( 26360958 )
2015
33
Congenital Cytomegalovirus Infection in Monozygotic Twins with Twin-to-twin Transfusion Syndrome. ( 26061933 )
2015
34
Outcome following selective fetoscopic laser ablation for twin to twin transfusion syndrome: an 8 year national collaborative experience. ( 26117441 )
2015
35
Short-Time Impact of Laser Ablation of Placental Anastomoses on Myocardial Function in Monochorionic Twins with Twin-to-Twin Transfusion Syndrome. ( 26331331 )
2015
36
Visualisation of the vascular equator in twin-to-twin transfusion syndrome by virtual fetoscopy. ( 26411581 )
2015
37
Perinatal outcome after fetoscopic laser surgery for twin-to-twin transfusion syndrome in triplet pregnancies: systematic review. ( 26265264 )
2015
38
Postnatal survival after endoscopic equatorial laser for the treatment of twin-to-twin transfusion syndrome. ( 26517964 )
2015
39
Prediction of single fetal demise after laser therapy for twin-to-twin transfusion syndrome. ( 26395988 )
2015
40
Influences of Different Doses of Midazolam on Mother and Fetus in Fetoscopic Surgery for Twin-to-Twin Transfusion Syndrome. ( 26279077 )
2015
41
Twin-to-twin transfusion syndrome: prenatal diagnosis and treatment. ( 24858318 )
2014
42
Iatrogenic perforation of intertwin membrane after laser surgery for twin-to-twin transfusion syndrome. ( 24961923 )
2014
43
Predictive value of cardiovascular parameters in twin-to-twin transfusion syndrome. ( 24585420 )
2014
44
Is the Sequential Laser Technique for Twin-to-Twin Transfusion Syndrome Truly Superior to the Standard Selective Technique? A Meta-Analysis. ( 25139419 )
2014
45
Long term developmental outcomes of pre-school age children following laser surgery for twin-to-twin transfusion syndrome. ( 25463829 )
2014
46
Pediatric and Perinatal Pathology: SY21-1 LATE-ONSET AND REVERSED CHRONIC TWIN-TO-TWIN TRANSFUSION SYNDROME. ( 25188139 )
2014
47
Re: Iatrogenic perforation of intertwin membrane after laser surgery for twin-to-twin transfusion syndrome. S. H. P. Peeters, T. T. Stolk, F. Slaghekke, J. M. Middeldorp, F. J. Klumper, E. Lopriore and D. Oepkes. Ultrasound Obstet Gynecol 2014; 44: 550-556. ( 25363897 )
2014
48
Fetal cardiac parameters for prediction of twin-to-twin transfusion syndrome. ( 24919586 )
2014
49
Twin-to-twin transfusion syndrome: knowing our boundaries. ( 24613025 )
2014
50
Hirschsprung's disease in twin to twin transfusion syndrome: a case report. ( 25516683 )
2014

Variations for Twin-to-Twin Transfusion Syndrome

Expression for Twin-to-Twin Transfusion Syndrome

Search GEO for disease gene expression data for Twin-to-Twin Transfusion Syndrome.

Pathways for Twin-to-Twin Transfusion Syndrome

Pathways related to Twin-to-Twin Transfusion Syndrome according to GeneCards Suite gene sharing:

(show all 16)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.48 ANGPT1 ANGPT2 FLT1 PGF TUBB3 VEGFC
2
Show member pathways
13.18 ANGPT1 ANGPT2 FLT1 PGF VEGFC
3
Show member pathways
13.04 ANGPT1 ANGPT2 FLT1 PGF VEGFC
4
Show member pathways
12.7 ANGPT1 ANGPT2 FLT1 PGF TUBB3 VEGFC
5
Show member pathways
12.69 FLT1 PGF REN VEGFC
6
Show member pathways
12.35 FLT1 PGF VEGFC
7 12.19 ANGPT1 ANGPT2 FLT1 PGF VEGFC
8
Show member pathways
12.01 FLT1 PGF VEGFC
9
Show member pathways
11.99 ANGPT1 ANGPT2 FLT1 PGF VEGFC
10 11.73 ANGPT2 FLT1 VEGFC
11 11.54 ANGPT1 ANGPT2 FLT1
12
Show member pathways
11.46 FLT1 PGF VEGFC
13 11.09 ANGPT1 ANGPT2
14 10.96 ANGPT2 ENG FLT1 REN VEGFC
15 10.88 ANGPT2 ENG
16 10.81 ANGPT1 FLT1

GO Terms for Twin-to-Twin Transfusion Syndrome

Cellular components related to Twin-to-Twin Transfusion Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.43 ANGPT1 ANGPT2 FLT1 PGF REN VEGFC
2 extracellular space GO:0005615 9.17 ANGPT1 ANGPT2 ENG FLT1 PGF REN

Biological processes related to Twin-to-Twin Transfusion Syndrome according to GeneCards Suite gene sharing:

(show all 19)
id Name GO ID Score Top Affiliating Genes
1 multicellular organism development GO:0007275 9.89 ANGPT1 ANGPT2 FLT1 PGF VEGFC
2 cell differentiation GO:0030154 9.85 ANGPT1 ANGPT2 FLT1 PGF VEGFC
3 response to drug GO:0042493 9.73 ENG PGF REN VEGFC
4 response to hypoxia GO:0001666 9.69 ANGPT2 PGF VEGFC
5 positive regulation of endothelial cell proliferation GO:0001938 9.58 PGF VEGFC
6 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.58 ANGPT1 FLT1
7 animal organ regeneration GO:0031100 9.57 ANGPT2 PGF
8 positive regulation of cell division GO:0051781 9.56 PGF VEGFC
9 positive chemotaxis GO:0050918 9.55 ANGPT1 VEGFC
10 blood vessel morphogenesis GO:0048514 9.54 ANGPT2 FLT1
11 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.54 FLT1 PGF VEGFC
12 positive regulation of blood vessel endothelial cell migration GO:0043536 9.52 ANGPT1 VEGFC
13 induction of positive chemotaxis GO:0050930 9.48 PGF VEGFC
14 positive regulation of mast cell chemotaxis GO:0060754 9.4 PGF VEGFC
15 positive regulation of angiogenesis GO:0045766 9.35 ANGPT2 ENG FLT1 PGF VEGFC
16 sprouting angiogenesis GO:0002040 9.33 ANGPT1 ENG PGF
17 glomerulus vasculature development GO:0072012 9.32 ANGPT1 ANGPT2
18 Tie signaling pathway GO:0048014 9.26 ANGPT1 ANGPT2
19 angiogenesis GO:0001525 9.1 ANGPT1 ANGPT2 ENG FLT1 PGF VEGFC

Molecular functions related to Twin-to-Twin Transfusion Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 receptor binding GO:0005102 9.13 ANGPT1 ANGPT2 REN
2 receptor tyrosine kinase binding GO:0030971 8.62 ANGPT1 ANGPT2

Sources for Twin-to-Twin Transfusion Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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