MCID: TWN001
MIFTS: 46

Twin-to-Twin Transfusion Syndrome malady

Categories: Rare diseases, Blood diseases, Fetal diseases

Aliases & Classifications for Twin-to-Twin Transfusion Syndrome

About this section
Sources:
11Disease Ontology, 13DISEASES, 30ICD10, 31ICD10 via Orphanet, 36MalaCards, 39MeSH, 45NCIt, 48NIH Rare Diseases, 54Orphanet, 62SNOMED-CT, 68UMLS
See all MalaCards sources

Aliases & Descriptions for Twin-to-Twin Transfusion Syndrome:

Name: Twin-to-Twin Transfusion Syndrome 36 11 48 13
Twin to Twin Transfusion Syndrome 48 54
Fetal Blood Loss from Fetal Hemorrhage into Co-Twin 11
Fetus-to-Fetus Placental Transfusion Syndrome 68
Feto-Fetal Transfusion Syndrome 54
Fetofetal Transfusion Syndrome 48
Twin Twin Transfusion Syndrome 36
 
Fetal Hemorrhage into Co-Twin 11
Twin-to-Twin Blood Transfer 11
Fetal Transfusion Syndrome 48
Twin to Twin Transfusion 11
Fetofetal Transfusion 39
Ttts 48

Classifications:



External Ids:

Disease Ontology11 DOID:13576
MeSH39 D005330
SNOMED-CT62 13404009, 237299001
NCIt45 C113824
Orphanet54 ORPHA95431
ICD10 via Orphanet31 O43.0

Summaries for Twin-to-Twin Transfusion Syndrome

About this section
NIH Rare Diseases:48 Twin to twin transfusion syndrome (TTTS) is a rare condition that occurs during a twin pregnancy when blood moves from one twin (the “donor twin”) to the other (the “recipient twin”) while in the womb. TTTS is a complication that specifically occurs in identical (monozygotic) twin pregnancies that share the same egg sac (monochorionic) that may or may not share the same amniotic sac (monoamniotic). TTTS usually develops between 15 and 26 weeks of pregnancy. The donor twin may be born smaller, with paleness, anemia, and dehydration. The recipient twin may be born larger, with redness, too much blood, and increased blood pressure, resulting in an increased risk for heart failure. Treatment may require repeated amniocentesis during pregnancy. Fetal laser surgery may be done to interrupt the flow of blood from one twin to the other. After birth, treatment depends on the infant's specific symptoms. The donor twin may need a blood transfusion to treat anemia. The recipient twin may need to have the volume of body fluid reduced. This may involve an exchange transfusion. Medications may be given to treat heart failure in the recipient twin. Last updated: 7/21/2016

MalaCards based summary: Twin-to-Twin Transfusion Syndrome, also known as twin to twin transfusion syndrome, is related to myocardial infarction and idiopathic progressive polyneuropathy. An important gene associated with Twin-to-Twin Transfusion Syndrome is PGF (Placental Growth Factor), and among its related pathways are Angiogenesis (WikiPathways) and VEGF Pathway (Qiagen). Affiliated tissues include placenta, heart and cervix, and related mouse phenotypes are muscle and immune system.

Wikipedia:71 Twin-to-twin transfusion syndrome (TTTS), also known as Feto-Fetal Transfusion Syndrome (FFTS) and Twin... more...

Related Diseases for Twin-to-Twin Transfusion Syndrome

About this section

Diseases related to Twin-to-Twin Transfusion Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 61)
idRelated DiseaseScoreTop Affiliating Genes
1myocardial infarction28.9ANGPT1, NPPA, PGF, REN
2idiopathic progressive polyneuropathy10.4FLT1, PGF
3spinal muscular atrophy-dandy-walker malformation-cataracts syndrome10.4FLT1, PGF
4spinal cord astrocytoma10.3ENG, FLT1
5lipoatrophy with diabetes, leukomelanodermic papules, liver steatosis, and hypertrophic cardiomyopathy10.3FLT1, PGF
6chikungunya10.2ENG, FLT1
7silver-russell syndrome due to 7p11.2p13 microduplication10.2NPPA, REN
8cerebritis10.2
9hypodermyasis10.2NPPA, REN
10repetitive motion disorders10.2NPPA, REN
11ovarian cancer10.1NPPA, REN
12chylocele of tunica vaginalis10.1NPPA, REN
13mental depression10.1NPPA, REN
14acute liver failure10.1NPPA, REN
15bladder neck cancer10.1NPPA, REN
16noma10.1ENG, FLT1, PGF
17heart disease10.1
18cervicitis10.1
19polycythemia10.1
20polyhydramnios10.1
21exophthalmic ophthalmoplegia10.1ENG, FLT1, PGF
22preeclampsia/eclampsia 110.1ENG, FLT1, PGF
23frontal sinus cancer10.1ENG, FLT1, PGF
24pleural tuberculosis10.1ENG, FLT1, PGF
25hematopoietic stem cell transplantation10.0ENG, FLT1
26opportunistic mycosis10.0ANGPT2, FLT1
27vertebral artery occlusion10.0ANGPT2, ENG
28congenital cytomegalovirus10.0
29cytomegalovirus infection10.0
30neuropathy, hereditary sensory and autonomic, type vi10.0ANGPT2, FLT1
31spinal canal and spinal cord meningioma10.0NPPA, REN
32diabetes mellitus, insulin-dependent, 39.9ANGPT1, ANGPT2
33hydranencephaly9.9
34polymicrogyria9.9
35apocrine adenoma9.9ANGPT2, FLT1, PGF
36craniosynostosis9.9NPPA, REN
37citrullinemia, adult-onset type ii9.9ANGPT2, FLT1, PGF
38pulmonary hypertension9.8
39arteriovenous fistula9.8
40cerebral palsy9.8
41limb ischemia9.8
42arteriovenous malformation9.8
43oligohydramnios9.8
44down syndrome9.8
45post-traumatic stress disorder9.8
46ischemia9.8
47hyperaldosteronism9.8
48peritonitis9.8
49pulmonary embolism9.8
50amniotic band syndrome9.8

Graphical network of the top 20 diseases related to Twin-to-Twin Transfusion Syndrome:



Diseases related to twin-to-twin transfusion syndrome

Symptoms & Phenotypes for Twin-to-Twin Transfusion Syndrome

About this section

MGI Mouse Phenotypes related to Twin-to-Twin Transfusion Syndrome according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.2ANGPT1, ENG, FLT1, NPPA, REN
2MP:00053878.1ANGPT1, ANGPT2, FLT1, PGF, REN, VEGFC
3MP:00053857.2ANGPT1, ANGPT2, ENG, FLT1, NPPA, PGF
4MP:00053767.2ANGPT1, ANGPT2, ENG, FLT1, NPPA, PGF

Drugs & Therapeutics for Twin-to-Twin Transfusion Syndrome

About this section

Drugs for Twin-to-Twin Transfusion Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 34)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1AnestheticsPhase 49001
2
Progesteroneapproved, vet_approvedPhase 353757-83-05994
Synonyms:
(S)-4-Pregnene-3,20-dione
(S)-Pregn-4-en-3,20-dione
(S)-Progesterone
.beta.-Progesterone
.delta.(sup4)-Pregnene-3,20-dione
.delta.4-Pregnene-3,20-dione
17.alpha.-Progesterone
17a-Progesterone
17alpha-Progesterone
17alpha-progesterone
17α-progesterone
1dbb
1h60
257630-50-5
3,20-Pregnene-4
32104FB6-BF81-4F6E-83C2-024DEEAEB272
4-Pregnen-3,20-dione
4-Pregnene-3,20-dione
46665_FLUKA
46665_RIEDEL
57-83-0
753497-20-0
8012-32-6
8023-13-0
AC-700
AC1L1LKF
AI3-51682
Agolutin
Akrolutin
BB_NC-0185
BHR-100
BIDD:ER0547
BIDD:PXR0094
BPBio1_000676
BRD-K64994968-001-03-6
BSPBio_000614
Bio-luton
C00410
CCRIS 533
CHEBI:17026
CHEMBL103
CID5994
CIDR
CMC_13406
COL-1620
CPD000058345
Colprosterone
Corlutin
Corlutina
Corluvite
Corporin
Corpus Luteum Hormone
Corpus luteum hormone
Crinone
Crinone (TN)
Crinone progesterone gel
Curretab
Cyclogest
Cyclogesterin
D00066
D4-Pregnene-3,20-dione
DB00396
DR-2011
Delalutin
Delta(4)-pregnene-3,20-dione
Duraprogen
EINECS 200-350-6
ETI-411
EU-0100895
Endometrin
Estima
FE-999913
Flavolutan
Fologenon
Gelbkoerperhormon
Gesterol
Gesterol 100
Gesterol 50
Gestiron
Gestone
Gestormone
Gestron
Glanducorpin
Gynlutin
Gynoluton
Gynolutone
HMS1569O16
HMS2051O05
HMS2090J07
HSDB 3389
Hormoflaveine
Hormoluton
Hydroxyprogesterone Caproate
Hydroxyprogesterone Caproic acid
LMST02030159
LS-234
Lingusorbs
Lipo-Lutin
Lipolutin
Lopac0_000895
Lucorteum
Lucorteum Sol
Lucorteum sol
Lugesteron
Luteal hormone
Luteinique
Luteocrin normale
Luteodyn
Luteogan
Luteohormone
Luteol
Luteol (VAN)
Luteopur
Luteosan
Luteostab
Luteovis
Luteum
Lutex
Lutidon
Lutin
Lutinus
Lutociclina
Lutocuclin M
Lutocyclin
Lutocyclin M
 
Lutocyclin m
Lutocylin
Lutocylol
Lutoform
Lutogyl
Lutogynon
Lutren
Lutromone
MLS000028517
MLS000758277
MLS001074187
MLS002222367
MPA
Membrettes
Methylpregnone
Micronized Progesterone
MolPort-001-794-643
NCGC00022185-03
NCGC00022185-04
NCGC00022185-05
NCGC00022185-06
NCGC00022185-07
NCGC00022185-08
NCGC00022185-09
NCGC00090798-01
NCGC00090798-02
NCI60_042166
NSC 64377
NSC 9704
NSC-9704
NSC64377
NSC9704
Nalutron
Natural Progesterone
P 0130
P0130_SIGMA
P0478
P3972_SIGMA
P6149_SIGMA
P7556_ALDRICH
P7556_SIGMA
P8783_SIGMA
P9776_SIGMA
PROGESTERONE
Percutacrine
Percutacrine Luteinique
Piaponon
Pranone
Pregn-4-en-3,20-dione
Pregn-4-ene-3,20-dione
Pregnene-3,20-dione
Pregnenedione
Prestwick0_000477
Prestwick1_000477
Prestwick2_000477
Prestwick3_000477
Prestwick_411
Primolut
Prochieve
Progeffik
Progekan
Progestan
Progestasert
Progesterol
Progesteron
Progesterona
Progesterona [INN-Spanish]
Progesterone
Progesterone (JP15/USP/INN)
Progesterone [INN:BAN:JAN]
Progesterone [Progestins]
Progesterone, water-soluble
Progesterone-Water Soluble
Progesterone: HBC complex
Progesteronum
Progesteronum [INN-Latin]
Progestin
Progestogel
Progestol
Progeston
Progestone
Progestosol
Progestrel
Progestron
Progestronol
Progestérone
Projestaject
Prolets
Prolidon
Prolutin
Proluton
Prolutone
Prometrium
Prometrium (TN)
Prontogest
Protormone
S00293
S1705_Selleck
SAM001247039
SMR000058345
SMR000653542
SPBio_002553
SR-01000000088
SR-01000000088-5
Spectrum5_002053
Syngesterone
Syngestrets
Synovex S
Syntolutan
U 3672
UNII-4G7DS2Q64Y
Utrogest
Utrogestan
Vitarrine
WLN: L E5 B666 OV MUTJ A1 E1 FV1
ZINC04428529
beta-Progesterone
bmse000482
component of Cyclogesterin
corpus luteum hormone
delta(4)-Pregnene-3,20-dione
delta(Sup 4)-Pregnene-3,20-dione
delta(Sup4)-pregnene-3,20-dione
delta(sup 4)-Pregnene-3,20-dione
delta4-Pregnene-3,20-dione
luteohormone
nchembio.2007.53-comp14
3
LenalidomideapprovedPhase 3718191732-72-6216326
Synonyms:
1-oxo-2-(2,6-Dioxopiperidin-3-yl)-4-aminoisoindoline
191732-72-6
3-(4-Amino-1-oxo-1,3-dihydro-2H-isoindol-2-yl)piperidine-2,6-dione
3-(4-Amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione
3-(7-Amino-3-oxo-1H-isoindol-2-yl)-piperidine-2,6-dione
3-(7-amino-3-oxo-1H-isoindol-2-yl)piperidine-2,6-dione
346670-73-3
443912-14-9
AC-914
AC1L50II
AKOS005146276
ALBB-015321
Bio-0168
C467567
CC 5013
CC-5013
CC-5013, Revlimid, Lenalidomide
CC5013
CDC 501
CDC-501
CDC-5013
CHEMBL848
CID216326
Celgene brand of lenalidomide
D04687
 
DB00480
EC-000.2340
ENMD-0997
I06-0831
IMID-1
IMID-5013
IMiD3
IMiD3 cpd
IMid-1
LS-184040
Lenalidomide
Lenalidomide (USAN/INN)
Lenalidomide [USAN]
MolPort-003-848-370
NCGC00167491-01
NSC747972
Revamid
Revimid
Revlimid
Revlimid (Celgene)
Revlimid (TN)
S1029_Selleck
STK639603
Thalidomide analog CC-5013
UNII-F0P408N6V4
lenalidomide
4Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 312767
5Anti-Bacterial AgentsPhase 310884
6ProgestinsPhase 3546
7HormonesPhase 313979
8Hormone AntagonistsPhase 312778
911-hydroxyprogesteronePhase 331
1017-alpha-hydroxy-progesterone caproatePhase 331
11Estrogen AntagonistsPhase 31315
12EstrogensPhase 32470
13Epoetin alfaPhase 3645113427-24-0
14Immunosuppressive AgentsPhase 312770
15HematinicsPhase 31630
16Angiogenesis InhibitorsPhase 34143
17Angiogenesis Modulating AgentsPhase 34072
18Anti-Infective AgentsPhase 321402
19CaproateNutraceuticalPhase 333
20
Epinephrineapproved, vet_approved93351-43-45816
Synonyms:
(-)-(R)-Epinephrine
(-)-3,4-Dihydroxy-a-[2-(methylamino)ethyl]benzyl alcohol
(-)-3,4-Dihydroxy-alpha-((methylamino)methyl)benzyl alcohol
(-)-3,4-Dihydroxy-alpha-[2-(methylamino)ethyl]benzyl alcohol
(-)-3,4-dihydroxy-a-[(methylamino)methyl]-Benzyl alcohol
(-)-3,4-dihydroxy-alpha-[(methylamino)methyl]-Benzyl alcohol
(-)-Adrenalin
(-)-Adrenaline
(-)-Epinephrine
(-)-R-Epinephrine
(R)-(-)-Adnephrine
(R)-(-)-Adrenaline
(R)-(-)-Epinephrine
(R)-(-)-Epirenamine
(R)-(−)-adrenaline
(R)-4-[1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol
(R)-4-[1-hydroxy-2-(methylamino)ethyl]-1,2-Benzenediol
(R)-Adrenaline
(R)-Epinephrine
(−)-adrenaline
02252_FLUKA
1-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
1-Adrenalin
1-Epinephrine
4-(1-Hydroxy-2-(methylamino)ethyl)-1,2-benzenediol
4-(1-hydroxy-2-methylamino-ethyl)benzene-1,2-diol
4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-Benzenediol
4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol
4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol
51-43-4
51-43-4 (FREE BASE)
51028-73-0
A0173
AC-13188
AC1L1L7B
ADR ADRENALINE
ADROP
AI3-19015
Adnephrine
Adrenal
Adrenalin
Adrenalin (TN)
Adrenalin in Oil
Adrenalin-Medihaler
Adrenalina
Adrenalina [DCIT]
Adrenaline
Adrenaline (JP15)
Adrenaline/Epinephrine
Adrenalinum
Adrenamine
Adrenan
Adrenapax
Adrenasol
Adrenatrate
Adrenine
Adrenodis
Adrenohorma
Adrenosan
Adrenutol
Adrin
Adrine
Ana-Guard
Ana-Kit
Antiasthmatique
Asmatane Mist
Asthma meter mist
Asthma-nefrin
Asthmahaler Mist
Asthmanefrin
Astmahalin
Astminhal
BIDD:GT0119
Balmadren
Bernarenin
Biorenine
Bosmin
Brevirenin
Bronkaid
Bronkaid Mist
Bronkaid Suspension Mist
Bupivacaine Hcl and Epinephrine
C00788
CCRIS 4812
CHEBI:28918
CHEMBL679
CID5816
Chelafrin
Citanest Forte
Corisol
D-Epifrin
D-Epinephrine
D00095
DB00668
Drenamist
Dylephrin
Dyspne-Inhal
E4250_SIGMA
EINECS 200-098-7
EPI E Z PEN JR
EPIPEN E Z PEN
EPIPEN JR
Epi EZ Pen Jr
Epifrin
Epiglaufrin
Epinefrin
Epinefrin [Czech]
Epinefrina
Epinefrina [INN-Spanish]
Epinephran
Epinephrin
Epinephrine
Epinephrine (USP)
Epinephrine (USP/INN)
Epinephrine [USAN:INN:JAN]
Epinephrine hydrochloride
Epinephrinum
Epinephrinum [INN-Latin]
Epipen
Epipen (TN)
Epipen Auto-Injector
Epipen EZ Pen
Epipen Jr.
Epipen Jr. Auto-Injector
Epirenamine
Epirenan
Epirenin
Epitrate
Eppy
Esphygmogenina
Exadrin
 
Glaucon
Glaucosan
Glauposine
Glycirenan
HSCI1_000215
HSDB 4289
Haemostasin
Haemostatin
Hektalin
Hemisine
Hemostasin
Hemostatin
Hypernephrin
Hyporenin
IOP
Intranefrin
Iontocaine
Isoptoepinal
Kidoline
L-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
L-Adrenaline
L-Adrenaline Base
L-Epinehphrine
L-Epinephrine
L-Epirenamine
L-Methylaminoethanolcatechol
L-epinephrine
LS-156
Levo-Methylaminoethanolcatechol
Levoadrenaline
Levoepinephrine
Levorenen
Levorenin
Levorenine
Levoreninum
Lopac-E-4642
Lyodrin
Lyophrin
Medihaler-Epi
Metanephrin
Methylaminoethanolcatechol
Methylarterenol
Micronefrin
Micronephrine
MolPort-002-051-368
Mucidrina
Myosthenine
Mytrate
NCGC00015417-01
NCGC00142615-01
NCGC00142615-03
NCGC00142615-04
NCGC00142615-05
NCGC00142615-06
NCGC00142615-07
NSC 62786
NSC62786
Nephridine
Nieraline
PDSP1_001120
PDSP2_001104
Paranephrin
Primatene
Primatene Mist
R-(-)-Epinephrine
R-Adrenaline
RCRA waste no. P042
Racemic Epinephrine
Racepinephrine
Rcra waste number P042
Renagladin
Renaglandin
Renaglandulin
Renaleptine
Renalina
Renoform
Renostypricin
Renostypticin
Renostyptin
SMP1_000227
ST069368
SUS-PHRINE SULFITE-FREE
Scurenaline
Septocaine
Simplene
Sindrenina
Soladren
Sphygmogenin
Stryptirenal
Styptirenal
Supracapsulin
Supradin
Supranefran
Supranephrane
Supranephrine
Supranol
Suprarenaline
Suprarenin
Suprel
Surenine
Surrenine
Sus-Phrine
Sus-phrine
Susphrine
Sympathin I
Takamina
Takamine
Tokamina
Tonogen
Twinject
Twinject 0.15
Twinject 0.3
Twinject 0.30
UNII-YKH834O4BH
Vaponefrin
Vasoconstrictine
Vasoconstrictor
Vasodrine
Vasoton
Vasotonin
adrenaline
bmse000316
d-Adrenaline
epinephrine
l-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
l-Adrenalin
l-Adrenaline
l-Epinephine
l-Epinephrine (synthetic)
l-Epirenamine
l-Methylaminoethanolcatechol
levoepinephrine
nchembio747-comp9
21
Lidocaineapproved, vet_approved1226137-58-63676
Synonyms:
.alpha.-(Diethylamino)-2,6-acetoxylidide
.alpha.-Diethylamino-2,6-dimethylacetanilide
.alpha.-Diethylaminoaceto-2,6-xylidide
.omega.-Diethylamino-2,6-dimethylacetanilide
137-58-6
2-(Diethylamino)-2',6'-acetoxylidide
2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide
2-Diethylamino-N-(2,6-dimethyl-phenyl)-acetamide
2-Diethylamino-N-(2,6-dimethylphenyl)acetamide
4-12-00-02538 (Beilstein Handbook Reference)
6108-05-0 (MONOHYDROCHLORIDE MONOHYDRATE))
6108-05-0 (mono-hydrochloride, mono-hydrate)
73-78-9 (mono-hydrochloride)
AB00053581
AC-10282
AC1L1GGQ
AC1Q2Z7J
AKOS001026768
ARONIS23855
After Burn Double Strength Gel
After Burn Double Strength Spray
After Burn Gel
After Burn Spray
Alphacaine
Anestacon
Anestacon Jelly
BIDD:GT0342
BPBio1_000197
BRD-K52662033-001-02-6
BRD-K52662033-003-05-5
BRN 2215784
BSPBio_000179
BSPBio_001359
BSPBio_003004
Bio-0767
Bio1_000379
Bio1_000868
Bio1_001357
Bio2_000079
Bio2_000559
C07073
C14H22N2O
CAS-73-78-9
CDS1_000283
CHEBI:6456
CHEMBL79
CID3676
CPD000058189
Cappicaine
Cito optadren
Cuivasil
D00358
DB00281
Dalcaine
Dentipatch
Dentipatch (TN)
DermaFlex
Diethylaminoaceto-2,6-xylidide
Dilocaine
DivK1c_000174
DivK1c_001323
Duncaine
EINECS 205-302-8
ELA-Max
EMBOLEX
Emla
Emla Cream
Esracaine
FT-0082378
Gravocain
HMS1791D21
HMS1989D21
HMS2051C21
HMS2089E15
HMS548M19
HSDB 3350
I01-2704
IDI1_000174
IDI1_033829
Isicaina
Isicaine
Jetocaine
KBio1_000174
KBio2_000079
KBio2_001598
KBio2_002647
KBio2_004166
KBio2_005215
KBio2_006734
KBio3_000157
KBio3_000158
KBio3_002224
KBioGR_000079
KBioGR_000599
KBioSS_000079
KBioSS_001598
L-Caine
L0156
L1026_SIGMA
L7757_SIGMA
LIDOCAINE (73-58-6 (MONOHYDROCHLORIDE)
LIDOPEN
LQZ
 
LS-805
Lanabiotic
Leostesin
Lida-Mantle
Lidocaina
Lidocaina [INN-Spanish]
Lidocaine (JP15/USP/INN)
Lidocaine (VAN)
Lidocaine Carbonate
Lidocaine Hydrocarbonate
Lidocaine Monohydrochloride
Lidocaine [USAN:INN:JAN]
Lidocainum
Lidocainum [INN-Latin]
Lidocaton
Lidoderm
Lidoject-1
Lidoject-2
Lignocaine
Lignocainum
Lingocaine
Lopac-L-5647
Lopac0_000669
MLS000069724
MLS000758263
MLS001074177
Maricaine
Maybridge1_002571
MolPort-001-783-478
N-(2,6-dimethylphenyl)-N(2),N(2)-diethylglycinamide
N-(2,6-dimethylphenyl)-N~2~,N~2~-diethylglycinamide
NCGC00015611-01
NCGC00015611-02
NCGC00015611-03
NCGC00015611-04
NCGC00015611-14
NCGC00022176-05
NCGC00022176-06
NCGC00022176-07
NCGC00022176-08
NCGC00022176-09
NINDS_000174
NSC 40030
NSC40030
Norwood Sunburn Spray
Octocaine
Octocaine-100
Octocaine-50
Prestwick0_000050
Prestwick1_000050
Prestwick2_000050
Prestwick3_000050
Remicaine
Rocephin Kit
Rucaina
S1357_Selleck
SAM001247018
SMR000058189
SPBio_001525
SPBio_002100
STK552033
Solarcaine
Solarcaine aloe extra burn relief cream
Solcain
Spectrum2_001343
Spectrum3_001392
Spectrum4_000070
Spectrum5_001549
Spectrum_001118
UNII-98PI200987
WLN: 2N2 & 1VMR B1 F1
Xilina
Xilocaina
Xilocaina [Italian]
Xllina
Xycaine
Xylestesin
Xylesthesin
Xylocain
Xylocaine
Xylocaine (TN)
Xylocaine 5% Spinal
Xylocaine CO2
Xylocaine Dental Ointment
Xylocaine Endotracheal
Xylocaine Test Dose
Xylocaine Viscous
Xylocaine-MPF
Xylocaine-MPF with Glucose
Xylocaine-Mpf
Xylocaine-Mpf with Glucose
Xylocard
Xylocitin
Xyloneural (free base)
Xylotox
Zilactin-L
Zingo
alfa-Dietilamino-2,6-dimetilacetanilide
alfa-Dietilamino-2,6-dimetilacetanilide [Italian]
alpha-Diethylamino-2,6-dimethylacetanilide
alpha-diethylamino-2,6-dimethylacetanilide
lidocaine
nchembio.65-comp16
α-diethylamino-2,6-dimethylacetanilide
22
Glucosamineapproved, Nutraceutical1823416-24-8439213
Synonyms:
(+)-2-amino-2-deoxy-D-glucopyranose
(2R,3R,4R,5S,6R)-3-amino-6-(hydroxymethyl)oxane-2,4,5-triol
(2S,5R)-3-amino-6-(hydroxymethyl)oxane-2,4,5-triol
(3R,4R,5S,6R)-3-amino-6-(hydroxymethyl)oxane-2,4,5-triol
14257-69-3
2-Amino-2-deoxy-D-Glucose
2-Amino-2-deoxy-D-glucopyranose
2-Amino-2-deoxy-D-glucose
2-Amino-2-deoxy-beta-D-glucopyranose
2-Amino-2-deoxyglucose
2-Aminoglucose
2-Deoxy-2-amino-D-glucose
2-Deoxy-2-aminoglucose
2-amino-2-deoxy-D-glucopyranose
2-amino-2-deoxyglucose
2351-15-7
28905-10-4
2B4D44B2-D5AC-4DA4-9BE6-A4AE9574E4A6
3416-24-8
4-04-00-02017 (Beilstein Handbook Reference)
58-87-7
58267-75-7
6490-70-6
880765-44-6
90-77-7
911653-84-4
AC1L2D1C
AC1L96WB
AC1L9B8P
AC1Q4UBH
BRN 1724602
BSPBio_002086
C00329
C08349
CHEBI:28393
CHEBI:47977
CHEMBL234432
CID18897
CID439213
CID441477
CPD0-1193
Chitosamine
Cosamin
D-(+)-Glucosamine
 
D-Glucosamine
D-glucosamine
D04334
DB01296
DivK1c_000261
EINECS 222-311-2
GCS
Glucosamina
Glucosamina [INN-Spanish]
Glucosamine (USAN/INN)
Glucosamine [USAN:INN]
Glucosaminum
Glucosaminum [INN-Latin]
HMS500N03
HSDB 7469
IDI1_000261
InChI=1/C6H13NO5/c7-3-5(10)4(9)2(1-8)12-6(3)11/h2-6,8-11H,1,7H2/t2-,3-,4-,5-,6-/m1/s1
KBio1_000261
KBio2_001311
KBio2_003879
KBio2_006447
KBio3_001306
KBioGR_000970
KBioSS_001311
LS-71671
MolPort-002-507-091
MolPort-003-944-937
NCGC00164421-01
NCGC00178826-01
NINDS_000261
SPBio_000477
STK801823
Spectrum2_000519
Spectrum3_000443
Spectrum4_000565
Spectrum5_000756
Spectrum_000831
Viartril-S
beta-D-Glucosamine
bmse000247
chitosamine
glucosamine
nchembio.189-comp4
nchembio.2007.41-comp7
nchembio.412-comp5
partially N-deacetylated poly-beta-1,6-N-acetyl-D-glucosamine
23Hypolipidemic Agents2721
24Racepinephrine933
25Central Nervous System Depressants12806
26Hypoglycemic Agents5733
27Lipid Regulating Agents2702
28Fibrinolytic Agents2317
29Antibiotics, Antitubercular6972
30Anticoagulants2516
31Antimetabolites11774
32Glucuronyl glucosamine glycan sulfate132
33Epinephryl borate933
34Anesthetics, Local3272

Interventional clinical trials:

(show all 14)
idNameStatusNCT IDPhase
1The Trial of Pessary After Laser for TTTSRecruitingNCT01334489Phase 4
2Randomized Controlled Trial Comparing a Conservative Management and Laser SurgeryRecruitingNCT01220011Phase 4
3Trial of Progesterone in Twins and Triplets to Prevent Preterm Birth (STTARS)CompletedNCT00099164Phase 3
4Lenalidomide With or Without Epoetin Alfa in Treating Patients With Myelodysplastic Syndrome and AnemiaActive, not recruitingNCT00843882Phase 3
5Fetoscopic Selective Laser Photocoagulation in Twin-Twin Transfusion SyndromeUnknown statusNCT00345852
6Selective Laser Photocoagulation of Communicating Vessels in Twin-Twin Transfusion SyndromeCompletedNCT01622049
7Anesthetic Management in Fetoscopic Surgery and Incidence of ComplicationsCompletedNCT02434926
8Sequential vs. Standard Laser Treatment of Twin-twin Transfusion SyndromeRecruitingNCT02122328
9The Utility of MRI Scoring to Predict Neurodevelopmental Outcomes in Survivors of Twin-to-Twin Transfusion SyndromeRecruitingNCT02249624
10Pessary to Prevent Prematurity in Twins in Case of Short CervixRecruitingNCT02328989
11Unequal Placental Sharing in Monochorionic Diamniotic Twins: an Observational StudyRecruitingNCT03024918
12Monochorial-diamniotic Pregnancies Complicated With a Twin-to-twin SyndromeActive, not recruitingNCT02611856
13Laser Photocoagulation in Twin to Twin Transfusion SyndromeEnrolling by invitationNCT02506049
14The Value of Prenatal Ultrasound in Complicated Twin Pregnancy and Its Correlation With Chromosomal AnomaliesNot yet recruitingNCT02732717

Search NIH Clinical Center for Twin-to-Twin Transfusion Syndrome


Cochrane evidence based reviews: fetofetal transfusion

Genetic Tests for Twin-to-Twin Transfusion Syndrome

About this section

Anatomical Context for Twin-to-Twin Transfusion Syndrome

About this section

MalaCards organs/tissues related to Twin-to-Twin Transfusion Syndrome:

36
Placenta, Heart, Cervix, Brain, Bone, Liver, Eye

Publications for Twin-to-Twin Transfusion Syndrome

About this section

Articles related to Twin-to-Twin Transfusion Syndrome:

(show top 50)    (show all 286)
idTitleAuthorsYear
1
Spontaneous resolution of mirror syndrome following fetal interventions for fetal anemia as a consequence of twin to twin transfusion syndrome. (27914652)
2017
2
The History of Treatment of Twin-to-Twin Transfusion Syndrome. (27203604)
2016
3
Future Directions in the Management of Twin-to-Twin Transfusion Syndrome. (27125296)
2016
4
Monochorionic diamniotic inA vitro fertilization twins have a decreased incidence of twin-to-twin transfusion syndrome. (26690011)
2016
5
Impact of Monochorionicity and Twin to Twin Transfusion Syndrome on Prenatal Attachment, Post Traumatic Stress Disorder, Anxiety and Depressive Symptoms. (26751570)
2016
6
Identifying families' shared disease experiences through a qualitative analysis of online twin-to-twin transfusion syndrome stories. (27422614)
2016
7
The 2016 Satellite Meeting of the International Society of Twin Studies: An Overview/Tribute to Irving I. Gottesman/Research: MZ Twinning After Single Embryo Transfer; Twin Study of Mononucleosis; Cerebral Injury After Twin-To-Twin Transfusion Syndrome Surgery/Human Interest: Sixteen Twin Pairs Born in a Single Hospital; Death of an Identical Twin Playwright; Twin Themes in Advertising; Conjoined Twins Separated in Saudi Arabia; Murder of One Twin By Her Co-Twin Disproved. (27524469)
2016
8
Laser Treatment of Twin-to-Twin Transfusion Syndrome. (27203606)
2016
9
Balancing Patient Access to Fetoscopic Laser Photocoagulation for Twin-to-Twin Transfusion Syndrome With Maintaining Procedural Competence: Are Collaborative Services Part of the Solution? (27087260)
2016
10
Twin-to-Twin Transfusion Syndrome: From Observational Evidence to Randomized Controlled Trials. (27075108)
2016
11
Cardiac Manifestations of Twin-to-Twin Transfusion Syndrome. (27087122)
2016
12
Intra-arterial calcifications in the recipient twin in twin-to-twin transfusion syndrome. (27834168)
2016
13
Long-Term Neurodevelopmental Outcome in Survivors of Twin-to-Twin Transfusion Syndrome. (27137794)
2016
14
Increased Risk Of Early-Onset Neonatal Sepsis After Laser Surgery For Twin-to-Twin Transfusion Syndrome. (27137630)
2016
15
Twin-to-Twin Transfusion Syndrome: Definition, Staging, and Ultrasound Assessment. (27203605)
2016
16
Early prediction of twin-to-twin transfusion syndrome: systematic review and meta-analysis. (27270878)
2016
17
Atypical twin-to-twin transfusion syndrome: prevalence inA aA populationA undergoing fetoscopic laser ablation of communicatingA placental vessels. (26827875)
2016
18
Evolution of Stage 1 Twin-to-Twin Transfusion Syndrome (TTTS): Systematic Review and Meta-Analysis. (27137946)
2016
19
The Placenta in Twin-to-Twin Transfusion Syndrome and Twin Anemia Polycythemia Sequence. (27098457)
2016
20
Fetoscopic laser photocoagulation in twin-to-twin transfusion syndrome: experience from a single institution. (27056209)
2016
21
A prospective pilot study of fetoscopic laser surgery for twin-to-twin transfusion syndrome between 26 and 27 weeks of gestation. (27590373)
2016
22
Fetal left modified myocardial performance index measured by the Auto Mod-MPI system: development of reference values and application to recipients of twin-to-twin transfusion syndrome. (26921842)
2016
23
Postnatal survival after endoscopic equatorial laser for the treatment of twin-to-twin transfusion syndrome. (26517964)
2015
24
Visualisation of the vascular equator in twin-to-twin transfusion syndrome by virtual fetoscopy. (26411581)
2015
25
Short-Time Impact of Laser Ablation of Placental Anastomoses on Myocardial Function in Monochorionic Twins with Twin-to-Twin Transfusion Syndrome. (26331331)
2015
26
Prediction of single fetal demise after laser therapy for twin-to-twin transfusion syndrome. (26395988)
2015
27
Pseudoamniotic Band Syndrome after In Utero Intervention for Twin-to-Twin Transfusion Syndrome: Case Reports and Literature Review. (25613236)
2015
28
Congenital Cytomegalovirus Infection in Monozygotic Twins with Twin-to-twin Transfusion Syndrome. (26061933)
2015
29
Perinatal outcome after fetoscopic laser surgery for twin-to-twin transfusion syndrome in triplet pregnancies: systematic review. (26265264)
2015
30
Transient twin reversed arterial perfusion: a protective effect in twin-to-twin transfusion syndrome? (26360958)
2015
31
Longitudinal annular displacement by M-mode (MAPSE and TAPSE) in twin-to-twin transfusion syndrome before and after laser surgery. (26256442)
2015
32
Outcome following selective fetoscopic laser ablation for twin to twin transfusion syndrome: an 8 year national collaborative experience. (26117441)
2015
33
Influences of Different Doses of Midazolam on Mother and Fetus in Fetoscopic Surgery for Twin-to-Twin Transfusion Syndrome. (26279077)
2015
34
Congenital heart disease in monochorionic twins with and without twin-to-twin transfusion syndrome. (24827120)
2014
35
Diagnosis of twin-to-twin transfusion syndrome, selective fetal growth restriction, twin anaemia-polycythaemia sequence, and twin reversed arterial perfusion sequence. (24433823)
2014
36
Iatrogenic perforation of intertwin membrane after laser surgery for twin-to-twin transfusion syndrome. (24961923)
2014
37
Predictive value of cardiovascular parameters in twin-to-twin transfusion syndrome. (24585420)
2014
38
Is the Sequential Laser Technique for Twin-to-Twin Transfusion Syndrome Truly Superior to the Standard Selective Technique? A Meta-Analysis. (25139419)
2014
39
Right ventricular failure with high echoic ventricular wall change after foetoscopic laser photocoagulation: a case report of a donor in twin-to-twin transfusion syndrome. (25522791)
2014
40
Stage-Related Outcome after Fetoscopic Laser Ablation in Twin-to-Twin Transfusion Syndrome. (25096484)
2014
41
Comparison of fetal myocardial contractility before and after laser photocoagulation of communicating vessels in twin-to-twin transfusion syndrome. (24834706)
2014
42
Pediatric and Perinatal Pathology: SY21-1 LATE-ONSET AND REVERSED CHRONIC TWIN-TO-TWIN TRANSFUSION SYNDROME. (25188139)
2014
43
Re: Iatrogenic perforation of intertwin membrane after laser surgery for twin-to-twin transfusion syndrome. S. H. P. Peeters, T. T. Stolk, F. Slaghekke, J. M. Middeldorp, F. J. Klumper, E. Lopriore and D. Oepkes. Ultrasound Obstet Gynecol 2014; 44: 550-556. (25363897)
2014
44
Outcome of fetoscopic laser ablation for twin-to-twin transfusion syndrome in dichorionic-triamniotic triplets compared with monochorionic-diamniotic twins. (24659447)
2014
45
Twin-to-Twin transfusion syndrome--30 years at the front. (24915564)
2014
46
Fetal cardiac parameters for prediction of twin-to-twin transfusion syndrome. (24919586)
2014
47
Twin born with a skeletonized hand in twin-to-twin transfusion syndrome treated with laser ablation in pregnancy. (24835476)
2014
48
11p15 DNA-methylation analysis in monozygotic twins with discordant intrauterine development due to severe twin-to-twin transfusion syndrome. (24678997)
2014
49
Predictive value of cardiovascular parameters in stages 1 and 2 of twin-to-twin transfusion syndrome. (24760447)
2014
50
Hirschsprung's disease in twin to twin transfusion syndrome: a case report. (25516683)
2014

Variations for Twin-to-Twin Transfusion Syndrome

About this section

Expression for genes affiliated with Twin-to-Twin Transfusion Syndrome

About this section
Search GEO for disease gene expression data for Twin-to-Twin Transfusion Syndrome.

Pathways for genes affiliated with Twin-to-Twin Transfusion Syndrome

About this section

Pathways related to Twin-to-Twin Transfusion Syndrome according to GeneCards Suite gene sharing:

(show all 15)
idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.6ANGPT1, FLT1
2
Show member pathways
8.9FLT1, PGF, VEGFC
3
Show member pathways
8.9FLT1, PGF, VEGFC
4
Show member pathways
8.9FLT1, PGF, VEGFC
5
Show member pathways
8.9FLT1, PGF, VEGFC
68.7ANGPT2, FLT1, VEGFC
7
Show member pathways
8.5FLT1, PGF, REN, VEGFC
88.4ANGPT1, ANGPT2, FLT1, NPPA
9
Show member pathways
7.8ANGPT2, ENG, FLT1, REN, VEGFC
10
Show member pathways
7.8ANGPT1, ANGPT2, FLT1, PGF, VEGFC
11
Show member pathways
7.8ANGPT1, ANGPT2, FLT1, PGF, VEGFC
127.8ANGPT1, ANGPT2, FLT1, PGF, VEGFC
13
Show member pathways
7.8ANGPT1, ANGPT2, FLT1, PGF, VEGFC
14
Show member pathways
7.8ANGPT1, ANGPT2, FLT1, PGF, VEGFC
15
Show member pathways
7.8ANGPT1, ANGPT2, FLT1, PGF, VEGFC

GO Terms for genes affiliated with Twin-to-Twin Transfusion Syndrome

About this section

Cellular components related to Twin-to-Twin Transfusion Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055767.9ANGPT1, ANGPT2, NPPA, PGF, REN, VEGFC
2extracellular spaceGO:00056156.4ANGPT1, ANGPT2, ENG, FLT1, NPPA, PGF

Biological processes related to Twin-to-Twin Transfusion Syndrome according to GeneCards Suite gene sharing:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of phosphatidylinositol 3-kinase signalingGO:001406810.3ANGPT1, FLT1
2animal organ regenerationGO:003110010.2ANGPT2, PGF
3blood vessel morphogenesisGO:004851410.2ANGPT2, FLT1
4regulation of blood pressureGO:000821710.2NPPA, REN
5glomerulus vasculature developmentGO:007201210.0ANGPT1, ANGPT2
6positive regulation of cell divisionGO:005178110.0PGF, VEGFC
7positive chemotaxisGO:00509189.8ANGPT1, VEGFC
8Tie signaling pathwayGO:00480149.8ANGPT1, ANGPT2
9positive regulation of blood vessel endothelial cell migrationGO:00435369.8ANGPT1, VEGFC
10sprouting angiogenesisGO:00020409.7ANGPT1, ENG, PGF
11response to drugGO:00424939.5PGF, REN, VEGFC
12response to hypoxiaGO:00016669.1ANGPT2, FLT1, NPPA, PGF
13vascular endothelial growth factor receptor signaling pathwayGO:00480108.9FLT1, PGF, VEGFC
14positive regulation of angiogenesisGO:00457668.6ANGPT2, ENG, FLT1, PGF, VEGFC
15angiogenesisGO:00015258.4ANGPT1, ANGPT2, ENG, FLT1, VEGFC

Molecular functions related to Twin-to-Twin Transfusion Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1receptor tyrosine kinase bindingGO:00309719.3ANGPT1, ANGPT2
2receptor bindingGO:00051028.8ANGPT1, ANGPT2, NPPA, REN

Sources for Twin-to-Twin Transfusion Syndrome

About this section
2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet