MCID: TWN001
MIFTS: 54

Twin-to-Twin Transfusion Syndrome malady

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Summaries for Twin-to-Twin Transfusion Syndrome

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65Wikipedia, 33MalaCards
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Wikipedia:65 Twin-to-twin transfusion syndrome (TTTS, also known as Feto-Fetal Transfusion Syndrome (FFTS) and Twin... more...

MalaCards: Twin-to-Twin Transfusion Syndrome, also known as fetal blood loss from fetal hemorrhage into co-twin, is related to hyperaldosteronism and congenital heart disease. An important gene associated with Twin-to-Twin Transfusion Syndrome is ANGPT2 (angiopoietin 2), and among its related pathways are HIF1Alpha Pathway and Angiogenesis. The compounds isosorbide-5-mononitrate and cicletanine have been mentioned in the context of this disorder. Affiliated tissues include placenta, heart and brain, and related mouse phenotypes are muscle and renal/urinary system.

Aliases & Classifications for Twin-to-Twin Transfusion Syndrome

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8Disease Ontology, 10DISEASES, 49Orphanet, 62UMLS, 35MeSH, 58SNOMED-CT, 59SNOMED-CT via Orphanet, 26ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Blood diseases


Aliases & Descriptions:

twin-to-twin transfusion syndrome 8 10
fetal blood loss from fetal hemorrhage into co-twin 8
ffts - fetofetal transfusion syndrome 62
twin to twin transfusion syndrome 49
feto-fetal transfusion syndrome 49
fetal hemorrhage into co-twin 8
twin-to-twin blood transfer 8
twin to twin transfusion 8


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Disease Ontology8 DOID:13576
MeSH35 D005330
SNOMED-CT via Orphanet59 13404009
ICD10 via Orphanet26 O43.0

Related Diseases for Twin-to-Twin Transfusion Syndrome

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17GeneCards, 18GeneDecks
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Diseases in the Twin-to-Twin Transfusion Syndrome family:

Twin Twin Transfusion Syndrome

Diseases related to Twin-to-Twin Transfusion Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 75)
idRelated DiseaseScoreTop Affiliating Genes
1hyperaldosteronism30.5REN, NPPA
2congenital heart disease30.4NPPA, EDN1
3hypertension30.3EDN1, REN, PGF, NPPA
4ischemia30.3EDN1, VEGFC, PGF, ANGPT2, ANGPT1
5myocardial infarction30.2REN, NPPA, ANGPT1, PAPPA, PGF, EDN1
6cerebritis10.6
7polyhydramnios10.5
8cervicitis10.5
9twin twin transfusion syndrome10.5
10polycythemia10.5
11arteriovenous fistula10.3
12limb ischemia10.3
13arteriovenous malformation10.3
14down syndrome10.3
15cerebral palsy10.3
16oligohydramnios10.3
17peritonitis10.3
18pulmonary embolism10.3
19amniotic band syndrome10.3
20congenital cytomegalovirus10.3
21hydrops fetalis10.3
22transposition of the great arteries10.3
23cytomegalovirus infection10.3
24hypoaldosteronism10.1REN
25congestive heart failure10.1REN
26placental insufficiency10.1ANGPT2, PGF
27pre-eclampsia10.1PAPPA
28pyogenic granuloma10.1ANGPT2, ANGPT1
29renovascular hypertension10.0NPPA, REN
30gestational diabetes10.0PAPPA, PGF
31diabetic retinopathy10.0PGF, ANGPT2
32conn's syndrome10.0NPPA, REN
33pure autonomic failure10.0NPPA, REN
34hemangioma10.0ANGPT1, ANGPT2
35acute kidney failure10.0REN, NPPA
36papillary thyroid carcinoma10.0VEGFC, ANGPT2
37renal hypertension10.0REN, EDN1
38portal hypertension10.0REN, EDN1
39low renin hypertension10.0REN, EDN1
40angiosarcoma10.0ANGPT1, VEGFC, ANGPT2
41thyroid cancer10.0ANGPT1, ANGPT2, VEGFC
42endometrial carcinoma10.0ANGPT1, ANGPT2, VEGFC
43stomach cancer10.0VEGFC, ANGPT2, ANGPT1
44cor pulmonale10.0EDN1, NPPA
45idiopathic edema10.0EDN1, NPPA
46arteriosclerosis10.0EDN1, ANGPT1
47primary pulmonary hypertension10.0NPPA, EDN1
48glomerulosclerosis10.0EDN1, REN
49glioblastoma multiforme10.0ANGPT2, VEGFC, ANGPT1
50proliferative diabetic retinopathy10.0EDN1, ANGPT1, ANGPT2

Graphical network of the top 20 diseases related to Twin-to-Twin Transfusion Syndrome:



Diseases related to twin-to-twin transfusion syndrome

Symptoms for Twin-to-Twin Transfusion Syndrome

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Drugs & Therapeutics for Twin-to-Twin Transfusion Syndrome

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Twin-to-Twin Transfusion Syndrome

Search NIH Clinical Center for Twin-to-Twin Transfusion Syndrome

Genetic Tests for Twin-to-Twin Transfusion Syndrome

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Anatomical Context for Twin-to-Twin Transfusion Syndrome

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33MalaCards
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MalaCards organs/tissues related to Twin-to-Twin Transfusion Syndrome:

33
Placenta, Heart, Brain, Eye, Bone, Liver, Cervix

Animal Models for Twin-to-Twin Transfusion Syndrome or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Twin-to-Twin Transfusion Syndrome:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.5EDN1, ANGPT1, NPPA, REN
2MP:00053678.2REN, ANGPT1, NPPA, EDN1
3MP:00053766.8EDN1, VEGFC, PGF, PAPPA, REN, ANGPT2
4MP:00053856.4NPPA, EDN1, VEGFC, PGF, PAPPA, REN

Publications for Twin-to-Twin Transfusion Syndrome

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Sources:
52PubMed
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Articles related to Twin-to-Twin Transfusion Syndrome:

(show top 50)    (show all 227)
idTitleAuthorsYear
1
Diagnosis of twin-to-twin transfusion syndrome, selective fetal growth restriction, twin anaemia-polycythaemia sequence, and twin reversed arterial perfusion sequence. (24433823)
2014
2
Fetoscopic laser therapy for twin-to-twin transfusion syndrome. (23395141)
2013
3
Maternal Perception of Decreased Fetal Movement in One Twin: A Clue Leading to the Early Detection of Absent Variability due to Acute Twin-to-Twin Transfusion Syndrome. (23984131)
2013
4
Preoperative prediction of the individualized risk of early fetal death after laser therapy in twin-to-twin transfusion syndrome. (23813911)
2013
5
Twin-to-twin transfusion syndrome: a case study. (23360857)
2013
6
Neonatal urinary ascites complicated by ileal perforation in a recipient of twin-to-twin transfusion syndrome. (23255026)
2013
7
Fetal and maternal complications after selective fetoscopic laser surgery for twin-to-twin transfusion syndrome: a single-center experience. (22456330)
2012
8
Evaluation of the measurement of the middle cerebral artery peak systolic velocity before and after placental laser coagulation in twin-to-twin transfusion syndrome. (22418955)
2012
9
Evaluation of cardiac performance by abdominal fetal ECG in twin-to-twin transfusion syndrome. (22886606)
2012
10
Arabin cervical pessary to prevent preterm birth in severe twin-to-twin transfusion syndrome treated by laser surgery. (23055333)
2012
11
Assessment of right ventricular function in recipient twin of twin to twin transfusion syndrome with speckle tracking echocardiography. (22766115)
2012
12
Sonography-based Automated Volume Count to estimate fetal urine production in twin-to-twin transfusion syndrome: comparison with Virtual Organ Computer-aided AnaLysis. (21906713)
2011
13
Laser therapy for twin-to-twin transfusion syndrome causing amniotic band syndrome. (21037281)
2011
14
Laser ablation of placental vessels in twin-to-twin transfusion syndrome: a paradigm for endoscopic fetal surgery. (21854207)
2011
15
Laser therapy for twin-to-twin transfusion syndrome (TTTS). (21660997)
2011
16
The Fetal Heart in Twin-to-Twin Transfusion Syndrome. (20811613)
2010
17
Prospective assessment of fetal cardiac function with speckle tracking in healthy fetuses and recipient fetuses of twin-to-twin transfusion syndrome. (20138468)
2010
18
Management of Stage I twin-to-twin transfusion syndrome: an international survey. (20104530)
2010
19
Amniotic fluid markers of fetal cardiac dysfunction in twin-to-twin transfusion syndrome. (19801144)
2010
20
Preoperative predictors of death in twin-to-twin transfusion syndrome treated with laser ablation of placental anastomoses. (20691964)
2010
21
Survival after laser surgery for twin-to-twin transfusion syndrome: when are they out of the woods? (19159719)
2009
22
Extreme polycythemia in recipient twin with twin-to-twin transfusion syndrome: a case report. (19372698)
2009
23
Twin-to-twin transfusion syndrome: what nurses need to know. (19523136)
2009
24
The pediatric surgeons' contribution to in utero treatment of twin-to-twin transfusion syndrome. (19644353)
2009
25
Miniature bending manipulator for fetoscopic intrauterine laser therapy to treat twin-to-twin transfusion syndrome. (17661138)
2008
26
Discordance in nuchal translucency thickness in the prediction of severe twin-to-twin transfusion syndrome. (17444560)
2007
27
Comparing cranial ultrasound results in twin-to-twin transfusion syndrome treated with laser surgery. (17403389)
2007
28
Fetoscopic laser surgery in 100 pregnancies with severe twin-to-twin transfusion syndrome in the Netherlands. (17228157)
2007
29
Intertwin discordance in umbilical venous volume flow: a reflection of blood volume imbalance in twin-to-twin transfusion syndrome. (17323309)
2007
30
Timely diagnosis of twin-to-twin transfusion syndrome in monochorionic twin pregnancies by biweekly sonography combined with patient instruction to report onset of symptoms. (16969785)
2006
31
Monochorionic diamniotic infants without twin-to-twin transfusion syndrome. (16281049)
2005
32
Magnetic resonance imaging of the feto-placentar unit after fetoscopic laser coagulation for twin-to-twin transfusion syndrome. (15981732)
2005
33
Minimal-access fetal surgery for twin-to-twin transfusion syndrome. (14625725)
2004
34
Pulmonary artery calcification in recipient twins of twin to twin transfusion syndrome: a report of three cases. (12574984)
2003
35
Use of continuous fluid drainage for severe polyhydramnios due to twin to twin transfusion syndrome. (11491373)
2001
36
Twin reversed arterial perfusion sequence in twin-to-twin transfusion syndrome after the death of the donor co-twin in the second trimester. (11251926)
2001
37
Preoperative planning with magnetic resonance imaging and computerized volume rendering in twin-to-twin transfusion syndrome. (11483931)
2001
38
Pulmonary stenosis in recipient twins in twin-to-twin transfusion syndrome: report on 3 cases and review of literature. (10962042)
2000
39
Internet resources for researching twin-to-twin transfusion syndrome. (10806544)
2000
40
Ultrasound in the diagnosis of twin-to-twin transfusion syndrome--a preliminary report. (10916568)
1998
41
Alternative technique for Nd: YAG laser coagulation in twin-to-twin transfusion syndrome with anterior placenta. (9644775)
1998
42
Severe twin-to-twin transfusion syndrome: a new sonographic feature of the placenta. (9286028)
1997
43
Amniotic fluid pressure in twin-to-twin transfusion syndrome: an objective prognostic factor. (8739584)
1996
44
Lenticulostriate vasculopathy in twin-to-twin transfusion syndrome: sonographic and CT findings. (8577550)
1995
45
Twin-to-twin transfusion syndrome type III--case report of an intrauterine death in monochorionic pregnancy. (7653204)
1995
46
Indomethacin in severe twin-to-twin transfusion syndrome. (8442793)
1993
47
Ultrasonography and Doppler studies in twin-to-twin transfusion syndrome. (1492805)
1992
48
Twin-to-twin transfusion syndrome. (2201194)
1990
49
Diagnosis of twin to twin transfusion syndrome at 18 weeks of gestation. (6417174)
1983
50
Twin-to-twin transfusion syndrome. (5198153)
1970

Variations for Twin-to-Twin Transfusion Syndrome

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Expression for genes affiliated with Twin-to-Twin Transfusion Syndrome

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Twin-to-Twin Transfusion Syndrome

Search GEO for disease gene expression data for Twin-to-Twin Transfusion Syndrome.

Pathways for genes affiliated with Twin-to-Twin Transfusion Syndrome

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Sources:
50PathCards, 53QIAGEN, 5Cell Signaling Technology, 55Reactome, 38NCBI BioSystems Database, 51PharmGKB, 57SinoBiological, 30KEGG
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Pathways related to Twin-to-Twin Transfusion Syndrome according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4VEGFC, EDN1
29.3VEGFC, ANGPT2, REN
3
Show member pathways
9.3ANGPT2, ANGPT1, VEGFC
4
Show member pathways
VEGFR1 specific signals38
9.2VEGFC, PGF
5
Show member pathways
9.2VEGFC, PGF
6
Show member pathways
9.2PGF, VEGFC
7
Show member pathways
8.9PGF, REN, VEGFC
8
Show member pathways
8.6EDN1, VEGFC, ANGPT1, ANGPT2
98.5EDN1, ANGPT1, NPPA, ANGPT2
10
Show member pathways
8.4PGF, VEGFC, ANGPT1, ANGPT2
11
Show member pathways
8.4ANGPT1, PGF, VEGFC, ANGPT2
128.4VEGFC, PGF, ANGPT1, ANGPT2
13
Show member pathways
8.4ANGPT1, VEGFC, PGF, ANGPT2
14
Show member pathways
8.4PGF, VEGFC, ANGPT1, ANGPT2
15
Show member pathways
8.4ANGPT2, ANGPT1, PGF, VEGFC

Compounds for genes affiliated with Twin-to-Twin Transfusion Syndrome

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Sources:
45Novoseek, 29IUPHAR, 51PharmGKB, 11DrugBank, 61Tocris Bioscience, 24HMDB
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Compounds related to Twin-to-Twin Transfusion Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 104)
idCompoundScoreTop Affiliating Genes
1isosorbide-5-mononitrate459.9REN, NPPA
2cicletanine459.9REN, NPPA
3ibopamine459.9NPPA, REN
4alacepril459.9REN, NPPA
551-cr-edta459.9REN, NPPA
6darusentan45 2910.8REN, EDN1
7lacidipine459.7EDN1, REN
8muraglitazar45 5110.7EDN1, REN
9fenoldopam45 1110.7REN, NPPA
10fludrocortisone45 29 1111.7REN, NPPA
11bisoprolol45 51 1111.6NPPA, REN
12ribonucleic acid459.6VEGFC, ANGPT1, ANGPT2
13fosinopril45 1110.6REN, NPPA
14bq12345 2910.5NPPA, EDN1
15inulin459.5REN, NPPA
16progestin459.4ANGPT2, PAPPA, ANGPT1
17toki-shakuyaku-san459.4EDN1, REN, NPPA
18urodilatin459.4REN, NPPA, EDN1
19trandolapril45 1110.4REN, EDN1, NPPA
20cilazapril45 1110.4REN, EDN1, NPPA
21omapatrilat459.4EDN1, REN, NPPA
22hanp459.4EDN1, REN, NPPA
23quinapril45 51 1111.4EDN1, REN, NPPA
24enalaprilat459.4NPPA, REN, EDN1
25enalapril45 51 1111.4EDN1, REN, NPPA
26carvedilol45 51 29 1112.4NPPA, REN, EDN1
27guanylate459.4ANGPT2, NPPA, ANGPT1
28nitroglycerin45 1110.4REN, NPPA, EDN1
29captopril45 61 51 29 1113.3EDN1, REN, NPPA
30ang ii459.3NPPA, REN, EDN1
31sildenafil29 45 51 24 1113.3NPPA, ANGPT1, EDN1
32losartan45 51 29 1112.3NPPA, REN, EDN1
33sodium nitroprusside459.2REN, NPPA, EDN1
34nifedipine45 29 51 1112.0EDN1, REN, NPPA
35ng-nitro-l-arginine458.9NPPA, EDN1, PGF
36thymidine45 249.9ANGPT2, ANGPT1, VEGFC, EDN1
37matrigel458.8ANGPT2, ANGPT1, PGF, VEGFC
38cyclosporin a45 29 6110.8ANGPT1, EDN1, ANGPT2, NPPA
39paraffin458.8ANGPT2, ANGPT1, PGF, VEGFC
40cgmp45 299.7EDN1, NPPA, REN
41pge2458.6NPPA, ANGPT2, VEGFC, EDN1, REN
42pd 98,059458.5VEGFC, EDN1, ANGPT1, PGF
43phosphatidylinositol458.2PGF, ANGPT2, ANGPT1, VEGFC, EDN1
44prostacyclin458.1PGF, REN, NPPA, EDN1, ANGPT1
45glucose458.0ANGPT2, REN, PAPPA, PGF, ANGPT1, VEGFC
46oxygen45 248.7VEGFC, ANGPT2, ANGPT1, PGF, EDN1, NPPA
47creatinine457.7PAPPA, ANGPT2, REN, PGF, EDN1, NPPA
48nitric oxide45 24 119.4PGF, REN, ANGPT1, VEGFC, EDN1, NPPA
49vegf456.9EDN1, VEGFC, PGF, PAPPA, REN, ANGPT1
50calcium45 51 24 119.8NPPA, ANGPT1, ANGPT2, VEGFC, PGF, PAPPA

GO Terms for genes affiliated with Twin-to-Twin Transfusion Syndrome

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16Gene Ontology
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Cellular components related to Twin-to-Twin Transfusion Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055766.4EDN1, VEGFC, PGF, PAPPA, REN, ANGPT1
2extracellular spaceGO:0056156.1EDN1, VEGFC, PGF, PAPPA, REN, ANGPT1

Biological processes related to Twin-to-Twin Transfusion Syndrome according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1Tie signaling pathwayGO:04801410.0ANGPT2, ANGPT1
2glomerulus vasculature developmentGO:0720129.9ANGPT2, ANGPT1
3positive regulation of blood vessel endothelial cell migrationGO:0435369.9ANGPT1, VEGFC
4positive chemotaxisGO:0509189.8VEGFC, ANGPT1
5positive regulation of endothelial cell migrationGO:0105959.5ANGPT1, EDN1
6vascular endothelial growth factor receptor signaling pathwayGO:0480109.4PGF, VEGFC
7sprouting angiogenesisGO:0020409.4ANGPT1, PGF
8organ regenerationGO:0311009.4ANGPT2, PGF
9positive regulation of cell divisionGO:0517819.4PGF, VEGFC
10regulation of blood pressureGO:0082179.3NPPA, REN
11blood coagulationGO:0075969.3ANGPT2, ANGPT1, VEGFC
12female pregnancyGO:0075658.9PGF, PAPPA, NPPA
13cell differentiationGO:0301548.7PGF, PAPPA, ANGPT1
14positive regulation of cell proliferationGO:0082848.5PGF, VEGFC, EDN1
15response to hypoxiaGO:0016668.5NPPA, ANGPT2, PGF, EDN1

Molecular functions related to Twin-to-Twin Transfusion Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1receptor tyrosine kinase bindingGO:0309719.4ANGPT2, ANGPT1
2receptor bindingGO:0051029.2NPPA, ANGPT2, REN

Products for genes affiliated with Twin-to-Twin Transfusion Syndrome

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Sources for Twin-to-Twin Transfusion Syndrome

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet