MCID: TWN001
MIFTS: 54

Twin-to-Twin Transfusion Syndrome malady

Blood diseases, Rare diseases categories

Summaries for Twin-to-Twin Transfusion Syndrome

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66Wikipedia, 34MalaCards
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Wikipedia:66 Twin-to-twin transfusion syndrome (TTTS, also known as Feto-Fetal Transfusion Syndrome (FFTS) and Twin... more...

MalaCards: Twin-to-Twin Transfusion Syndrome, also known as fetal blood loss from fetal hemorrhage into co-twin, is related to hyperaldosteronism and congenital heart disease. An important gene associated with Twin-to-Twin Transfusion Syndrome is ANGPT2 (angiopoietin 2), and among its related pathways are HIF1Alpha Pathway and Angiogenesis. The compounds isosorbide-5-mononitrate and cicletanine have been mentioned in the context of this disorder. Affiliated tissues include placenta, heart and brain, and related mouse phenotypes are muscle and renal/urinary system.

Aliases & Classifications for Twin-to-Twin Transfusion Syndrome

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9Disease Ontology, 11DISEASES, 50Orphanet, 63UMLS, 36MeSH, 59SNOMED-CT, 60SNOMED-CT via Orphanet, 27ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Blood diseases


Aliases & Descriptions:

twin-to-twin transfusion syndrome 9 11
fetal blood loss from fetal hemorrhage into co-twin 9
ffts - fetofetal transfusion syndrome 63
twin to twin transfusion syndrome 50
feto-fetal transfusion syndrome 50
fetal hemorrhage into co-twin 9
twin-to-twin blood transfer 9
twin to twin transfusion 9


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Disease Ontology9 DOID:13576
MeSH36 D005330
SNOMED-CT via Orphanet60 13404009
ICD10 via Orphanet27 O43.0

Related Diseases for Twin-to-Twin Transfusion Syndrome

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18GeneCards, 19GeneDecks
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Diseases in the Twin-to-Twin Transfusion Syndrome family:

Twin Twin Transfusion Syndrome

Diseases related to Twin-to-Twin Transfusion Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 75)
idRelated DiseaseScoreTop Affiliating Genes
1hyperaldosteronism30.5REN, NPPA
2congenital heart disease30.4NPPA, EDN1
3hypertension30.3EDN1, REN, PGF, NPPA
4ischemia30.3EDN1, VEGFC, PGF, ANGPT2, ANGPT1
5myocardial infarction30.2REN, NPPA, ANGPT1, PAPPA, PGF, EDN1
6cerebritis10.6
7polyhydramnios10.5
8cervicitis10.5
9twin twin transfusion syndrome10.5
10polycythemia10.5
11arteriovenous fistula10.3
12limb ischemia10.3
13arteriovenous malformation10.3
14down syndrome10.3
15cerebral palsy10.3
16oligohydramnios10.3
17peritonitis10.3
18pulmonary embolism10.3
19amniotic band syndrome10.3
20congenital cytomegalovirus10.3
21hydrops fetalis10.3
22transposition of the great arteries10.3
23cytomegalovirus infection10.3
24hypoaldosteronism10.1REN
25congestive heart failure10.1REN
26placental insufficiency10.1ANGPT2, PGF
27pre-eclampsia10.1PAPPA
28pyogenic granuloma10.1ANGPT2, ANGPT1
29renovascular hypertension10.0NPPA, REN
30gestational diabetes10.0PAPPA, PGF
31diabetic retinopathy10.0PGF, ANGPT2
32conn's syndrome10.0NPPA, REN
33pure autonomic failure10.0NPPA, REN
34hemangioma10.0ANGPT1, ANGPT2
35acute kidney failure10.0REN, NPPA
36papillary thyroid carcinoma10.0VEGFC, ANGPT2
37renal hypertension10.0REN, EDN1
38portal hypertension10.0REN, EDN1
39low renin hypertension10.0REN, EDN1
40angiosarcoma10.0ANGPT1, VEGFC, ANGPT2
41thyroid cancer10.0ANGPT1, ANGPT2, VEGFC
42endometrial carcinoma10.0ANGPT1, ANGPT2, VEGFC
43stomach cancer10.0VEGFC, ANGPT2, ANGPT1
44cor pulmonale10.0EDN1, NPPA
45idiopathic edema10.0EDN1, NPPA
46arteriosclerosis10.0EDN1, ANGPT1
47primary pulmonary hypertension10.0NPPA, EDN1
48glomerulosclerosis10.0EDN1, REN
49glioblastoma multiforme10.0ANGPT2, VEGFC, ANGPT1
50proliferative diabetic retinopathy10.0EDN1, ANGPT1, ANGPT2

Graphical network of the top 20 diseases related to Twin-to-Twin Transfusion Syndrome:



Diseases related to twin-to-twin transfusion syndrome

Symptoms for Twin-to-Twin Transfusion Syndrome

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Drugs & Therapeutics for Twin-to-Twin Transfusion Syndrome

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Twin-to-Twin Transfusion Syndrome

Drug clinical trials:

Search ClinicalTrials for Twin-to-Twin Transfusion Syndrome

Search NIH Clinical Center for Twin-to-Twin Transfusion Syndrome

Search CenterWatch for Twin-to-Twin Transfusion Syndrome

Genetic Tests for Twin-to-Twin Transfusion Syndrome

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Anatomical Context for Twin-to-Twin Transfusion Syndrome

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34MalaCards
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MalaCards organs/tissues related to Twin-to-Twin Transfusion Syndrome:

34
Placenta, Heart, Brain, Eye, Bone, Liver, Cervix

Animal Models for Twin-to-Twin Transfusion Syndrome or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Twin-to-Twin Transfusion Syndrome:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.5EDN1, ANGPT1, NPPA, REN
2MP:00053678.2REN, ANGPT1, NPPA, EDN1
3MP:00053766.8EDN1, VEGFC, PGF, PAPPA, REN, ANGPT2
4MP:00053856.4NPPA, EDN1, VEGFC, PGF, PAPPA, REN

Publications for Twin-to-Twin Transfusion Syndrome

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Sources:
53PubMed
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Articles related to Twin-to-Twin Transfusion Syndrome:

(show top 50)    (show all 227)
idTitleAuthorsYear
1
Diagnosis of twin-to-twin transfusion syndrome, selective fetal growth restriction, twin anaemia-polycythaemia sequence, and twin reversed arterial perfusion sequence. (24433823)
2014
2
Fetoscopic laser therapy for twin-to-twin transfusion syndrome. (23395141)
2013
3
Maternal Perception of Decreased Fetal Movement in One Twin: A Clue Leading to the Early Detection of Absent Variability due to Acute Twin-to-Twin Transfusion Syndrome. (23984131)
2013
4
Preoperative prediction of the individualized risk of early fetal death after laser therapy in twin-to-twin transfusion syndrome. (23813911)
2013
5
Twin-to-twin transfusion syndrome: a case study. (23360857)
2013
6
Neonatal urinary ascites complicated by ileal perforation in a recipient of twin-to-twin transfusion syndrome. (23255026)
2013
7
Fetal and maternal complications after selective fetoscopic laser surgery for twin-to-twin transfusion syndrome: a single-center experience. (22456330)
2012
8
Evaluation of the measurement of the middle cerebral artery peak systolic velocity before and after placental laser coagulation in twin-to-twin transfusion syndrome. (22418955)
2012
9
Evaluation of cardiac performance by abdominal fetal ECG in twin-to-twin transfusion syndrome. (22886606)
2012
10
Arabin cervical pessary to prevent preterm birth in severe twin-to-twin transfusion syndrome treated by laser surgery. (23055333)
2012
11
Assessment of right ventricular function in recipient twin of twin to twin transfusion syndrome with speckle tracking echocardiography. (22766115)
2012
12
Sonography-based Automated Volume Count to estimate fetal urine production in twin-to-twin transfusion syndrome: comparison with Virtual Organ Computer-aided AnaLysis. (21906713)
2011
13
Laser therapy for twin-to-twin transfusion syndrome causing amniotic band syndrome. (21037281)
2011
14
Laser ablation of placental vessels in twin-to-twin transfusion syndrome: a paradigm for endoscopic fetal surgery. (21854207)
2011
15
Laser therapy for twin-to-twin transfusion syndrome (TTTS). (21660997)
2011
16
The Fetal Heart in Twin-to-Twin Transfusion Syndrome. (20811613)
2010
17
Prospective assessment of fetal cardiac function with speckle tracking in healthy fetuses and recipient fetuses of twin-to-twin transfusion syndrome. (20138468)
2010
18
Management of Stage I twin-to-twin transfusion syndrome: an international survey. (20104530)
2010
19
Amniotic fluid markers of fetal cardiac dysfunction in twin-to-twin transfusion syndrome. (19801144)
2010
20
Preoperative predictors of death in twin-to-twin transfusion syndrome treated with laser ablation of placental anastomoses. (20691964)
2010
21
Survival after laser surgery for twin-to-twin transfusion syndrome: when are they out of the woods? (19159719)
2009
22
Extreme polycythemia in recipient twin with twin-to-twin transfusion syndrome: a case report. (19372698)
2009
23
Twin-to-twin transfusion syndrome: what nurses need to know. (19523136)
2009
24
The pediatric surgeons' contribution to in utero treatment of twin-to-twin transfusion syndrome. (19644353)
2009
25
Miniature bending manipulator for fetoscopic intrauterine laser therapy to treat twin-to-twin transfusion syndrome. (17661138)
2008
26
Discordance in nuchal translucency thickness in the prediction of severe twin-to-twin transfusion syndrome. (17444560)
2007
27
Comparing cranial ultrasound results in twin-to-twin transfusion syndrome treated with laser surgery. (17403389)
2007
28
Fetoscopic laser surgery in 100 pregnancies with severe twin-to-twin transfusion syndrome in the Netherlands. (17228157)
2007
29
Intertwin discordance in umbilical venous volume flow: a reflection of blood volume imbalance in twin-to-twin transfusion syndrome. (17323309)
2007
30
Timely diagnosis of twin-to-twin transfusion syndrome in monochorionic twin pregnancies by biweekly sonography combined with patient instruction to report onset of symptoms. (16969785)
2006
31
Monochorionic diamniotic infants without twin-to-twin transfusion syndrome. (16281049)
2005
32
Magnetic resonance imaging of the feto-placentar unit after fetoscopic laser coagulation for twin-to-twin transfusion syndrome. (15981732)
2005
33
Minimal-access fetal surgery for twin-to-twin transfusion syndrome. (14625725)
2004
34
Pulmonary artery calcification in recipient twins of twin to twin transfusion syndrome: a report of three cases. (12574984)
2003
35
Use of continuous fluid drainage for severe polyhydramnios due to twin to twin transfusion syndrome. (11491373)
2001
36
Twin reversed arterial perfusion sequence in twin-to-twin transfusion syndrome after the death of the donor co-twin in the second trimester. (11251926)
2001
37
Preoperative planning with magnetic resonance imaging and computerized volume rendering in twin-to-twin transfusion syndrome. (11483931)
2001
38
Pulmonary stenosis in recipient twins in twin-to-twin transfusion syndrome: report on 3 cases and review of literature. (10962042)
2000
39
Internet resources for researching twin-to-twin transfusion syndrome. (10806544)
2000
40
Ultrasound in the diagnosis of twin-to-twin transfusion syndrome--a preliminary report. (10916568)
1998
41
Alternative technique for Nd: YAG laser coagulation in twin-to-twin transfusion syndrome with anterior placenta. (9644775)
1998
42
Severe twin-to-twin transfusion syndrome: a new sonographic feature of the placenta. (9286028)
1997
43
Amniotic fluid pressure in twin-to-twin transfusion syndrome: an objective prognostic factor. (8739584)
1996
44
Lenticulostriate vasculopathy in twin-to-twin transfusion syndrome: sonographic and CT findings. (8577550)
1995
45
Twin-to-twin transfusion syndrome type III--case report of an intrauterine death in monochorionic pregnancy. (7653204)
1995
46
Indomethacin in severe twin-to-twin transfusion syndrome. (8442793)
1993
47
Ultrasonography and Doppler studies in twin-to-twin transfusion syndrome. (1492805)
1992
48
Twin-to-twin transfusion syndrome. (2201194)
1990
49
Diagnosis of twin to twin transfusion syndrome at 18 weeks of gestation. (6417174)
1983
50
Twin-to-twin transfusion syndrome. (5198153)
1970

Variations for Twin-to-Twin Transfusion Syndrome

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Expression for genes affiliated with Twin-to-Twin Transfusion Syndrome

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Twin-to-Twin Transfusion Syndrome

Search GEO for disease gene expression data for Twin-to-Twin Transfusion Syndrome.

Pathways for genes affiliated with Twin-to-Twin Transfusion Syndrome

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Sources:
51PathCards, 54QIAGEN, 5Cell Signaling Technology, 56Reactome, 39NCBI BioSystems Database, 52PharmGKB, 58SinoBiological, 31KEGG
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Pathways related to Twin-to-Twin Transfusion Syndrome according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4VEGFC, EDN1
29.3VEGFC, ANGPT2, REN
3
Show member pathways
9.3ANGPT2, ANGPT1, VEGFC
4
Show member pathways
VEGFR1 specific signals39
9.2VEGFC, PGF
5
Show member pathways
9.2VEGFC, PGF
6
Show member pathways
9.2PGF, VEGFC
7
Show member pathways
8.9PGF, REN, VEGFC
8
Show member pathways
8.6EDN1, VEGFC, ANGPT1, ANGPT2
98.5EDN1, ANGPT1, NPPA, ANGPT2
10
Show member pathways
8.4PGF, VEGFC, ANGPT1, ANGPT2
11
Show member pathways
8.4ANGPT1, PGF, VEGFC, ANGPT2
128.4VEGFC, PGF, ANGPT1, ANGPT2
13
Show member pathways
8.4ANGPT1, VEGFC, PGF, ANGPT2
14
Show member pathways
8.4PGF, VEGFC, ANGPT1, ANGPT2
15
Show member pathways
8.4ANGPT2, ANGPT1, PGF, VEGFC

Compounds for genes affiliated with Twin-to-Twin Transfusion Syndrome

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Sources:
46Novoseek, 30IUPHAR, 52PharmGKB, 12DrugBank, 62Tocris Bioscience, 25HMDB
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Compounds related to Twin-to-Twin Transfusion Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 104)
idCompoundScoreTop Affiliating Genes
1isosorbide-5-mononitrate469.9REN, NPPA
2cicletanine469.9REN, NPPA
3ibopamine469.9NPPA, REN
4alacepril469.9REN, NPPA
551-cr-edta469.9REN, NPPA
6darusentan46 3010.8REN, EDN1
7lacidipine469.7EDN1, REN
8muraglitazar46 5210.7EDN1, REN
9fenoldopam46 1210.7REN, NPPA
10fludrocortisone46 30 1211.7REN, NPPA
11bisoprolol46 52 1211.6NPPA, REN
12ribonucleic acid469.6VEGFC, ANGPT1, ANGPT2
13fosinopril46 1210.6REN, NPPA
14bq12346 3010.5NPPA, EDN1
15inulin469.5REN, NPPA
16progestin469.4ANGPT2, PAPPA, ANGPT1
17toki-shakuyaku-san469.4EDN1, REN, NPPA
18urodilatin469.4REN, NPPA, EDN1
19trandolapril46 1210.4REN, EDN1, NPPA
20cilazapril46 1210.4REN, EDN1, NPPA
21omapatrilat469.4EDN1, REN, NPPA
22hanp469.4EDN1, REN, NPPA
23quinapril46 52 1211.4EDN1, REN, NPPA
24enalaprilat469.4NPPA, REN, EDN1
25enalapril46 52 1211.4EDN1, REN, NPPA
26carvedilol46 52 30 1212.4NPPA, REN, EDN1
27guanylate469.4ANGPT2, NPPA, ANGPT1
28nitroglycerin46 1210.4REN, NPPA, EDN1
29captopril46 62 52 30 1213.3EDN1, REN, NPPA
30ang ii469.3NPPA, REN, EDN1
31sildenafil30 46 52 25 1213.3NPPA, ANGPT1, EDN1
32losartan46 52 30 1212.3NPPA, REN, EDN1
33sodium nitroprusside469.2REN, NPPA, EDN1
34nifedipine46 30 52 1212.0EDN1, REN, NPPA
35ng-nitro-l-arginine468.9NPPA, EDN1, PGF
36thymidine46 259.9ANGPT2, ANGPT1, VEGFC, EDN1
37matrigel468.8ANGPT2, ANGPT1, PGF, VEGFC
38cyclosporin a46 30 6210.8ANGPT1, EDN1, ANGPT2, NPPA
39paraffin468.8ANGPT2, ANGPT1, PGF, VEGFC
40cgmp46 309.7EDN1, NPPA, REN
41pge2468.6NPPA, ANGPT2, VEGFC, EDN1, REN
42pd 98,059468.5VEGFC, EDN1, ANGPT1, PGF
43phosphatidylinositol468.2PGF, ANGPT2, ANGPT1, VEGFC, EDN1
44prostacyclin468.1PGF, REN, NPPA, EDN1, ANGPT1
45glucose468.0ANGPT2, REN, PAPPA, PGF, ANGPT1, VEGFC
46oxygen46 258.7VEGFC, ANGPT2, ANGPT1, PGF, EDN1, NPPA
47creatinine467.7PAPPA, ANGPT2, REN, PGF, EDN1, NPPA
48nitric oxide46 25 129.4PGF, REN, ANGPT1, VEGFC, EDN1, NPPA
49vegf466.9EDN1, VEGFC, PGF, PAPPA, REN, ANGPT1
50calcium46 52 25 129.8NPPA, ANGPT1, ANGPT2, VEGFC, PGF, PAPPA

GO Terms for genes affiliated with Twin-to-Twin Transfusion Syndrome

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Sources:
17Gene Ontology
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Cellular components related to Twin-to-Twin Transfusion Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055766.4EDN1, VEGFC, PGF, PAPPA, REN, ANGPT1
2extracellular spaceGO:0056156.1EDN1, VEGFC, PGF, PAPPA, REN, ANGPT1

Biological processes related to Twin-to-Twin Transfusion Syndrome according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1Tie signaling pathwayGO:04801410.0ANGPT2, ANGPT1
2glomerulus vasculature developmentGO:0720129.9ANGPT2, ANGPT1
3positive regulation of blood vessel endothelial cell migrationGO:0435369.9ANGPT1, VEGFC
4positive chemotaxisGO:0509189.8VEGFC, ANGPT1
5positive regulation of endothelial cell migrationGO:0105959.5ANGPT1, EDN1
6vascular endothelial growth factor receptor signaling pathwayGO:0480109.4PGF, VEGFC
7sprouting angiogenesisGO:0020409.4ANGPT1, PGF
8organ regenerationGO:0311009.4ANGPT2, PGF
9positive regulation of cell divisionGO:0517819.4PGF, VEGFC
10regulation of blood pressureGO:0082179.3NPPA, REN
11blood coagulationGO:0075969.3ANGPT2, ANGPT1, VEGFC
12female pregnancyGO:0075658.9PGF, PAPPA, NPPA
13cell differentiationGO:0301548.7PGF, PAPPA, ANGPT1
14positive regulation of cell proliferationGO:0082848.5PGF, VEGFC, EDN1
15response to hypoxiaGO:0016668.5NPPA, ANGPT2, PGF, EDN1

Molecular functions related to Twin-to-Twin Transfusion Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1receptor tyrosine kinase bindingGO:0309719.4ANGPT2, ANGPT1
2receptor bindingGO:0051029.2NPPA, ANGPT2, REN

Products for genes affiliated with Twin-to-Twin Transfusion Syndrome

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Sources for Twin-to-Twin Transfusion Syndrome

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet