TTTS
MCID: TWN006
MIFTS: 40

Twin Twin Transfusion Syndrome (TTTS) malady

Summaries for Twin Twin Transfusion Syndrome

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42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Twin-to-twin transfusion syndrome is a rare condition that occurs when blood moves from one identical twin (the “donor twin”) to the other (the “recipient twin”) while in the womb. the donor twin may be born smaller, with paleness, anemia, and dehydration. the recipient twin may be born larger, with redness, too much blood, and increased blood pressure, resulting in an increased risk for heart failure. treatment may require repeated amniocentesis during pregnancy. fetal laser surgery may be done to interrupt the flow of blood from one twin to the other. after birth, treatment depends on the infant's specific symptoms. the donor twin may need a blood transfusion to treat anemia. the recipient twin may need to have the volume of body fluid reduced. this may involve an exchange transfusion. medications may be given to treat heart failure in the recipient twin. last updated: 3/5/2009

MalaCards: Twin Twin Transfusion Syndrome, also known as ffts - fetofetal transfusion syndrome, is related to twin-to-twin transfusion syndrome and polyhydramnios. An important gene associated with Twin Twin Transfusion Syndrome is ASPRV1 (aspartic peptidase, retroviral-like 1), and among its related pathways are Rheumatoid arthritis and Pathways in cancer. The compounds mannitol and toki-shakuyaku-san have been mentioned in the context of this disorder. Affiliated tissues include heart and placenta, and related mouse phenotypes are renal/urinary system and embryogenesis.

Wikipedia:63 Twin-to-twin transfusion syndrome (TTTS, also known as Feto-Fetal Transfusion Syndrome (FFTS) and Twin... more...

Aliases & Classifications for Twin Twin Transfusion Syndrome

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42NIH Rare Diseases, 60UMLS
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Aliases & Descriptions:

twin twin transfusion syndrome 42
ffts - fetofetal transfusion syndrome 60
twin-to-twin transfusion syndrome 42
fetofetal transfusion syndrome 42
fetal transfusion syndrome 42
ttts 42


Related Diseases for Twin Twin Transfusion Syndrome

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17GeneCards, 18GeneDecks
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Diseases in the Twin-to-Twin Transfusion Syndrome family:

twin twin transfusion syndrome

Diseases related to Twin Twin Transfusion Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 194)
idRelated DiseaseScoreTop Affiliating Genes
1twin-to-twin transfusion syndrome32.2PAPPA
2polyhydramnios30.8AFP
3hypertension30.6CST3, NPPA, EDN1, REN, PGF, ALB
4polycythemia30.5HIF1A
5retinopathy of prematurity30.5FLT1, VEGFA
6pulmonary embolism30.4ALB
7peritonitis30.4B2M, ALB
8down syndrome30.4AFP, PGF, PAPPA
9myocardial infarction30.3NPPA, EDN1, ANGPT1, HIF1A, REN, PGF
10oligohydramnios30.3AFP
11placental insufficiency30.3FLT1, ANGPT2, PGF
12ischemia30.3CST3, EDN1, FLT1, VEGFA, VEGFC, ANGPT1
13cerebritis10.7
14image syndrome10.5
15chorioamnionitis10.4
16arteriovenous fistula10.3
17arteriovenous malformation10.3
18adult syndrome10.3
19cerebral palsy10.3
20hydranencephaly10.2
21polymicrogyria10.2
22anuria10.2
23good syndrome10.2
24hypoplastic left heart syndrome10.2
25intestinal atresia10.2
26n syndrome10.2
27cervicitis10.2
28hyperaldosteronism10.2
29neutropenia10.2
30beta thalassemia10.0
31thalassemia10.0
32hepatitis10.0AFP
33gingivitis10.0CST3
34hypothyroidism10.0CST3
35cerebrovascular disease10.0CST3
36amyotrophic lateral sclerosis10.0CST3
37vesicoureteral reflux10.0AMBP
38gastroschisis10.0AFP
39multiple myeloma10.0B2M
40galactosemia10.0ALB
41vasculitis10.0ALB
42pancreatitis10.0ALB
43portal vein thrombosis10.0AFP
44neuropathy10.0ALB
45viral hepatitis10.0AFP
46meningitis10.0ALB
47kidney cancer10.0VEGFA
48glaucoma10.0EDN1
49congenital heart defect10.0NPPA
50crohn's disease10.0ALB

Graphical network of the top 20 diseases related to Twin Twin Transfusion Syndrome:



Diseases related to twin twin transfusion syndrome

Clinical Features for Twin Twin Transfusion Syndrome

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Drugs & Therapeutics for Twin Twin Transfusion Syndrome

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Twin Twin Transfusion Syndrome

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Anatomical Context for Twin Twin Transfusion Syndrome

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32MalaCards
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MalaCards organs/tissues related to Twin Twin Transfusion Syndrome:

32
Heart, Placenta

Animal Models for Twin Twin Transfusion Syndrome or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Twin Twin Transfusion Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053679.2EDN1, ANGPT1, HIF1A, REN
2MP:00053809.1AMBP, EDN1, PGF
3MP:00053698.7CST3, NPPA, FLT1, ANGPT1, HIF1A, REN
4MP:00053768.7CST3, NPPA, B2M, AFP, REN, PGF
5MP:00053818.6ALB, HIF1A, ANGPT2, VEGFA, B2M, EDN1
6MP:00020068.3CST3, B2M, AFP, VEGFA, HIF1A, PGF
7MP:00028737.6EDN1, FLT1, VEGFA, HIF1A, REN, ALB
8MP:00107687.0EDN1, FLT1, B2M, AFP, VEGFA, VEGFC
9MP:00053856.9ADD3, CST3, NPPA, EDN1, FLT1, B2M

Publications for Twin Twin Transfusion Syndrome

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Genetic Variations for Twin Twin Transfusion Syndrome

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Expression for genes affiliated with Twin Twin Transfusion Syndrome

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Twin Twin Transfusion Syndrome

Search GEO for disease gene expression data for Twin Twin Transfusion Syndrome.

Pathways for genes affiliated with Twin Twin Transfusion Syndrome

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29KEGG, 53Reactome, 51QIAGEN, 12EMD Millipore, 37NCBI BioSystems Database, 49PharmGKB, 55SinoBiological, 4Cell Signaling Technology
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Pathways related to Twin Twin Transfusion Syndrome according to GeneCards/GeneDecks:

(show all 23)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1ANGPT1
210.0HIF1A
3
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9.8CST3, NPPA, B2M
4
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9.7PGF, REN
5
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9.5ALB, VEGFC, VEGFA
6
Development Leptin signaling via JAK/STAT and MAPK cascades
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9.5EDN1, VEGFA, HIF1A
79.5HIF1A, VEGFA, EDN1
89.4HIF1A, VEGFC, EDN1
9
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9.1VEGFA, VEGFC, ANGPT1, ANGPT2
10
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9.0FLT1, VEGFC, ANGPT1, ANGPT2
118.9FLT1, VEGFA, ANGPT1, HIF1A
12
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8.9PGF, VEGFC, VEGFA, FLT1
13
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8.9PGF, VEGFC, VEGFA, FLT1
14
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8.9FLT1, VEGFA, VEGFC, PGF
15
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8.9FLT1, VEGFA, VEGFC, PGF
168.7REN, HIF1A, ANGPT2, VEGFC, FLT1
17
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8.5FLT1, VEGFC, ANGPT1, ANGPT2, PGF
18
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8.5FLT1, VEGFC, ANGPT1, ANGPT2, PGF
19
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8.5FLT1, VEGFC, ANGPT1, ANGPT2, PGF
20
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8.4FLT1, VEGFA, VEGFC, HIF1A, PGF
218.2FLT1, VEGFA, VEGFC, ANGPT1, ANGPT2, PGF
228.1HIF1A, NPPA, EDN1, FLT1, VEGFA, ANGPT1
23
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8.0FLT1, VEGFC, ANGPT1, ANGPT2, HIF1A, PGF

Compounds for genes affiliated with Twin Twin Transfusion Syndrome

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44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Twin Twin Transfusion Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 151)
idCompoundScoreTop Affiliating Genes
1mannitol44 1111.4ALB
2toki-shakuyaku-san4410.1EDN1, NPPA, REN
3uric acid44 2411.1CST3, AFP, B2M
4pge24410.0REN, VEGFC, VEGFA
5p-aminohippuric acid4410.0NPPA, ALB, B2M
6ramipril44 1110.9CST3, REN, ALB, NPPA
7urodilatin449.9EDN1, NPPA, REN
8lisinopril44 11 2411.8REN, ALB, NPPA, VEGFA
9perindopril44 49 1111.8VEGFA, ALB, NPPA, REN
10omapatrilat449.8REN, EDN1, NPPA
11carvedilol44 49 28 1112.7VEGFA, EDN1, NPPA, REN
1251-cr-edta449.7ALB, CST3, NPPA, B2M, REN
13sodium44 2410.7AMBP, AFP, REN, EDN1
14cilazapril44 1110.7EDN1, REN, NPPA
15iohexol449.6CST3, B2M, ALB, AMBP
16candesartan44 28 1111.5HIF1A, REN, ALB, VEGFA
17ang ii449.5NPPA, VEGFA, EDN1, REN
18potassium44 11 2411.5REN, ANGPT1, AFP, AMBP
19digoxin44 49 59 11 2413.5NPPA, HIF1A, CST3, REN
20trandolapril44 1110.5NPPA, REN, EDN1
21nitroglycerin44 1110.4EDN1, B2M, NPPA, REN, HIF1A
22captopril44 28 49 59 1113.4REN, B2M, ALB, CST3, EDN1, NPPA
23hanp449.4EDN1, NPPA, AMBP, B2M, REN
24kininogen449.4ALB, REN, NPPA, AMBP, CST3
25enalapril44 49 1111.4AMBP, NPPA, EDN1, REN, ALB
26sodium nitroprusside449.3NPPA, EDN1, B2M, HIF1A, REN
27celecoxib44 59 28 49 11 2414.3ALB, REN, HIF1A, ANGPT2, VEGFA
28urea44 11 2411.2AMBP, AFP, B2M, CST3, ALB
29inulin449.2AMBP, CST3, NPPA, B2M, REN, ALB
30nifedipine44 49 28 1112.2EDN1, B2M, AMBP, REN, NPPA
31matrigel449.1FLT1, HIF1A, ANGPT1, PGF
32sunitinib44 49 1111.1PGF, HIF1A, VEGFA, FLT1
33fibrinogen448.7AMBP, AFP, ANGPT1, ANGPT2, ALB, CST3
34glyceraldehyde 3-phosphate448.7B2M, FLT1, HIF1A, ANGPT2, ANGPT1, VEGFC
35oxygen44 249.7ANGPT2, ANGPT1, VEGFC, AFP, PGF, FLT1
36prostacyclin448.6VEGFA, ANGPT1, FLT1, EDN1, NPPA, PGF
37cyclosporin a44 28 5910.5ANGPT2, EDN1, B2M, ANGPT1, HIF1A, AMBP
38heparin44 28 11 2411.5AFP, VEGFA, PGF, FLT1, PAPPA
39doxorubicin44 49 1110.4HIF1A, FLT1, ANGPT1, AFP, VEGFA, B2M
40cisplatin44 49 59 1111.4HIF1A, CST3, B2M, AFP, VEGFA, AMBP
41thymidine44 249.2VEGFC, HIF1A, FLT1, EDN1, ANGPT2, B2M
42dexamethasone44 49 28 1111.1HIF1A, PAPPA, REN, AFP, VEGFA, VEGFC
43steroid447.8B2M, REN, ANGPT1, AMBP, AFP, ANGPT2
44nitric oxide44 11 249.7EDN1, HIF1A, FLT1, ANGPT1, ANGPT2, REN
45paraffin447.7FLT1, AFP, B2M, HIF1A, VEGFA, VEGFC
46creatinine447.7AMBP, CST3, NPPA, FLT1, AFP, ANGPT2
47lipid447.0ALB, AMBP, CST3, AFP, VEGFC, PGF
48glucose446.7FLT1, AMBP, PAPPA, PGF, REN, CST3
49vegf445.9PAPPA, FLT1, AFP, EDN1, NPPA, CST3
50calcium44 49 11 248.9CST3, AMBP, NPPA, B2M, VEGFC, EDN1

GO Terms for genes affiliated with Twin Twin Transfusion Syndrome

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16Gene Ontology
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Cellular components related to Twin Twin Transfusion Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.5ALB, VEGFC, VEGFA
2extracellular regionGO:0055765.5AMBP, CST3, NPPA, EDN1, B2M, VEGFA
3extracellular spaceGO:0056155.0ALB, AMBP, CST3, NPPA, EDN1, FLT1

Biological processes related to Twin Twin Transfusion Syndrome according to GeneCards/GeneDecks:

(show all 27)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of chemokine-mediated signaling pathwayGO:07010110.1EDN1, HIF1A
2glomerulus vasculature developmentGO:07201210.1ANGPT1, ANGPT2
3positive regulation of mast cell chemotaxisGO:06075410.1VEGFC, VEGFA
4Tie signaling pathwayGO:04801410.1ANGPT1, ANGPT2
5positive regulation of transcription from RNA polymerase II promoter in response to hypoxiaGO:06141910.0VEGFA, HIF1A
6positive regulation of endothelial cell migrationGO:0105959.9ANGPT1, VEGFA, EDN1
7positive regulation of receptor biosynthetic processGO:0108709.8HIF1A, EDN1
8induction of positive chemotaxisGO:0509309.8VEGFC, VEGFA
9patterning of blood vesselsGO:0015699.8EDN1, FLT1, VEGFA
10positive regulation of blood vessel endothelial cell migrationGO:0435369.8VEGFA, VEGFC, ANGPT1
11positive chemotaxisGO:0509189.8ANGPT1, VEGFC, VEGFA
12positive regulation of MAP kinase activityGO:0434069.8VEGFA, FLT1, EDN1
13positive regulation of protein autophosphorylationGO:0319549.7VEGFC, VEGFA
14positive regulation of neuroblast proliferationGO:0020529.7HIF1A, VEGFC, VEGFA
15positive regulation of vascular endothelial growth factor receptor signaling pathwayGO:0309499.7HIF1A, VEGFA, FLT1
16platelet degranulationGO:0025769.5VEGFA, VEGFC, ALB
17positive regulation of cell divisionGO:0517819.5VEGFA, VEGFC, PGF
18sprouting angiogenesisGO:0020409.5FLT1, ANGPT1, PGF
19dopaminergic neuron differentiationGO:0715429.4HIF1A, VEGFA
20positive regulation of endothelial cell proliferationGO:0019389.4PGF, HIF1A, VEGFA
21vascular endothelial growth factor receptor signaling pathwayGO:0480109.3PGF, VEGFC, VEGFA, FLT1
22angiogenesisGO:0015259.2VEGFA, VEGFC, ANGPT2, HIF1A
23response to hypoxiaGO:0016669.0EDN1, VEGFA, ANGPT2, HIF1A, PGF
24blood coagulationGO:0075969.0VEGFA, VEGFC, ANGPT1, ANGPT2, ALB
25positive regulation of cell proliferationGO:0082848.8EDN1, FLT1, VEGFA, VEGFC, PGF
26positive regulation of angiogenesisGO:0457668.8FLT1, VEGFA, ANGPT2, HIF1A, PGF
27female pregnancyGO:0075658.7AMBP, NPPA, PGF, PAPPA

Products for genes affiliated with Twin Twin Transfusion Syndrome

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Sources for Twin Twin Transfusion Syndrome

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3CDC
13ExPASy
14FMA
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23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
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40NDF-RT
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44Novoseek
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