TTTS
MCID: TWN006
MIFTS: 51

Twin Twin Transfusion Syndrome (TTTS) malady

Summaries for Twin Twin Transfusion Syndrome

Sources:
43NIH Rare Diseases, 64Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Twin-to-twin transfusion syndrome is a rare condition that occurs when blood moves from one identical twin (the “donor twin”) to the other (the “recipient twin”) while in the womb. the donor twin may be born smaller, with paleness, anemia, and dehydration. the recipient twin may be born larger, with redness, too much blood, and increased blood pressure, resulting in an increased risk for heart failure. treatment may require repeated amniocentesis during pregnancy. fetal laser surgery may be done to interrupt the flow of blood from one twin to the other. after birth, treatment depends on the infant's specific symptoms. the donor twin may need a blood transfusion to treat anemia. the recipient twin may need to have the volume of body fluid reduced. this may involve an exchange transfusion. medications may be given to treat heart failure in the recipient twin. last updated: 3/5/2009

MalaCards: Twin Twin Transfusion Syndrome, also known as ffts - fetofetal transfusion syndrome, is related to twin-to-twin transfusion syndrome and polyhydramnios. An important gene associated with Twin Twin Transfusion Syndrome is ASPRV1 (aspartic peptidase, retroviral-like 1), and among its related pathways are Rheumatoid arthritis and Pathways in cancer. The compounds mannitol and toki-shakuyaku-san have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and small intestine, and related mouse phenotypes are renal/urinary system and embryogenesis.

Wikipedia:64 Twin-to-twin transfusion syndrome (TTTS, also known as Feto-Fetal Transfusion Syndrome (FFTS) and Twin... more...

Aliases & Classifications for Twin Twin Transfusion Syndrome

Sources:
43NIH Rare Diseases, 61UMLS
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Aliases & Descriptions:

twin twin transfusion syndrome 43
ffts - fetofetal transfusion syndrome 61
twin-to-twin transfusion syndrome 43
fetofetal transfusion syndrome 43
fetal transfusion syndrome 43
ttts 43


Related Diseases for Twin Twin Transfusion Syndrome

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Twin Twin Transfusion Syndrome:



Diseases related to twin twin transfusion syndrome

Clinical Features for Twin Twin Transfusion Syndrome

Drugs & Therapeutics for Twin Twin Transfusion Syndrome

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Twin Twin Transfusion Syndrome

Drug clinical trials:

Search ClinicalTrials for Twin Twin Transfusion Syndrome

Search NIH Clinical Center for Twin Twin Transfusion Syndrome

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Genetic Tests for Twin Twin Transfusion Syndrome

Anatomical Context for Twin Twin Transfusion Syndrome

Sources:
33MalaCards
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MalaCards organs/tissues related to Twin Twin Transfusion Syndrome:

33
Brain, Heart, Small intestine, Kidney, Liver, Skin, Placenta, Cervix, B cells, Endothelial, Fetal brain, Fetal liver

Animal Models for Twin Twin Transfusion Syndrome or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Twin Twin Transfusion Syndrome

Sources:
51PubMed
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Articles related to Twin Twin Transfusion Syndrome:

(show top 50)    (show all 636)
idTitleAuthorsYear
1
Risk factors associated with preterm delivery after fetoscopic laser ablation for twin-twin transfusion syndrome. (24013922)
2014
2
Laser surgery in twin-twin transfusion syndrome with proximate cord insertions. (24157353)
2013
3
Maternal Perception of Decreased Fetal Movement in One Twin: A Clue Leading to the Early Detection of Absent Variability due to Acute Twin-to-Twin Transfusion Syndrome. (23984131)
2013
4
Twin-to-twin transfusion syndrome: a case study. (23360857)
2013
5
Evaluation of cardiac performance by abdominal fetal ECG in twin-to-twin transfusion syndrome. (22886606)
2012
6
Prevalence and risk factors of cerebral lesions in neonates after laser surgery for twin-twin transfusion syndrome. (23021698)
2012
7
Stage-based outcomes of 682 consecutive cases of twin-twin transfusion syndrome treated with laser surgery: the USFetus experience. (21411051)
2011
8
Prognosis and long-term neurodevelopmental outcome in conservatively treated twin-to-twin transfusion syndrome. (21510908)
2011
9
The Fetal Heart in Twin-to-Twin Transfusion Syndrome. (20811613)
2010
10
Management of Stage I twin-to-twin transfusion syndrome: an international survey. (20104530)
2010
11
Twin-twin transfusion syndrome: an ethics-based and evidence-based argument for clinical research. (20171601)
2010
12
The outcome and prognostic factors of twin-twin transfusion syndrome following fetoscopic laser surgery. (21064193)
2010
13
Twin-to-twin transfusion syndrome: what nurses need to know. (19523136)
2009
14
Selective fetoscopic laser ablation in 100 consecutive pregnancies with severe twin-twin transfusion syndrome. (19281575)
2009
15
Cardiac outcomes of hydrops as a result of twin-twin transfusion syndrome treated with laser surgery. (19208066)
2009
16
Retinopathy of prematurity in twin-twin transfusion syndrome. (19645402)
2009
17
Twin-twin transfusion syndrome: mathematical modelling. (18330860)
2008
18
Interventions for twin-twin transfusion syndrome: a Cochrane review. (18504775)
2008
19
Twin-to-twin transfusion syndrome: an antiangiogenic state? (18395032)
2008
20
Immune functions after severe twin-twin transfusion syndrome. (17378717)
2007
21
Congenital cystic adenomatoid malformation in twin-twin transfusion syndrome: fetal MR imaging. (17593361)
2007
22
Manifestation of mirror syndrome after fetoscopic laser photocoagulation in severe twin-twin transfusion syndrome. (16354975)
2006
23
Perinatal outcome in monochorionic twin pregnancies complicated by amniotic fluid discordance without severe twin-twin transfusion syndrome. (16323150)
2006
24
Monochorionic diamniotic infants without twin-to-twin transfusion syndrome. (16281049)
2005
25
Ileal atresia and thrombo-embolic liver calcifications diagnosed after treatment with intrauterine laser coagulation therapy for twin-to-twin transfusion syndrome: report of 2 cases. (15937836)
2005
26
Twin-twin transfusion syndrome. (14533898)
2003
27
Transient hydrops fetalis of the donor fetus in twin-twin transfusion syndrome after therapeutic amnioreduction. (12905515)
2003
28
Stage-based treatment of twin-twin transfusion syndrome. (12748508)
2003
29
Umbilical cord cyst in a monochorionic twin pregnancy: an experiment of nature for the treatment of twin-twin transfusion syndrome. (12065951)
2002
30
Transient hydropic signs in the donor fetus after fetoscopic laser coagulation in severe twin-twin transfusion syndrome: incidence and clinical relevance. (11982976)
2002
31
Discordant fetal leptin levels in monochorionic twins with chronic midtrimester twin-twin transfusion syndrome. (11373148)
2001
32
Amniotic fluid and hemodynamic model in monochorionic twin pregnancies and twin-twin transfusion syndrome. (11294775)
2001
33
Pathogenesis of twin-twin transfusion syndrome: the renin-angiotensin system hypothesis. (11399888)
2001
34
Natural history of twin-twin transfusion syndrome. (11396376)
2001
35
Prenatal diagnosis of twin-twin transfusion syndrome complicated with hydrops fetalis at 14 weeks of gestation. (11336735)
2001
36
Treatment of twin-twin transfusion syndrome (TTTS) with aggressive amnioreduction and/or fetoscopic laser therapy. (11503679)
2000
37
Sono-endoscopic delineation of the placental vascular equator prior to selective fetoscopic laser ablation in twin-to-twin transfusion syndrome. (11169287)
2000
38
Amniotic fluid pressure in both cavities of twin-to-twin transfusion syndrome: a vote against septostomy. (10720870)
2000
39
Twin-to-twin transfusion syndrome: treatment by amniodrainage and septostomy. (10986448)
2000
40
Fetal and neonatal echocardiographic findings in twin-twin transfusion syndrome. (9790398)
1998
41
Management of early onset severe twin-twin transfusion syndrome in the absence of fetoscopic equipment by exteriorisation, ligation and replacement of the umbilical cord of the sacrificed twin. (9608304)
1998
42
Prenatally detected reversal of donor-recipient roles in twin-to-twin transfusion syndrome following in utero treatment. (9141590)
1997
43
Gender differences in twin-twin transfusion syndrome. (9380319)
1997
44
Fetoscopic laser ablation of placental vessels in severe previable twin-twin transfusion syndrome. (7726257)
1995
45
Twin-twin transfusion syndrome. (7609763)
1995
46
Treatment of twin-twin transfusion syndrome. (8414335)
1993
47
Twin-twin transfusion syndrome during the 2nd trimester is associated with small intertwin hemoglobin differences. (1768344)
1991
48
Twin-to-twin transfusion syndrome. (2201194)
1990
49
Sinusoidal fetal heart rate pattern associated with the twin to twin transfusion syndrome. (1968022)
1990
50
Severe cervical stenosis with the twin-to-twin transfusion syndrome. (3393959)
1988

Genetic Variations for Twin Twin Transfusion Syndrome

Expression for genes affiliated with Twin Twin Transfusion Syndrome

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Twin Twin Transfusion Syndrome

Search GEO for disease gene expression data for Twin Twin Transfusion Syndrome.

Pathways for genes affiliated with Twin Twin Transfusion Syndrome

Sources:
30KEGG, 54Reactome, 52QIAGEN, 12EMD Millipore, 38NCBI BioSystems Database, 50PharmGKB, 56SinoBiological, 4Cell Signaling Technology
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Pathways related to Twin Twin Transfusion Syndrome according to GeneCards/GeneDecks:

(show all 23)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1ANGPT1
210.0HIF1A
3
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9.8CST3, B2M, NPPA
4
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9.7PGF, REN
5
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9.5VEGFA, VEGFC, ALB
6
Development Leptin signaling via JAK/STAT and MAPK cascades
Hide members
9.5VEGFA, HIF1A, EDN1
79.5EDN1, HIF1A, VEGFA
89.4EDN1, HIF1A, VEGFC
9
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9.1ANGPT2, ANGPT1, VEGFC, VEGFA
10
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9.0VEGFC, ANGPT1, ANGPT2, FLT1
118.9HIF1A, ANGPT1, VEGFA, FLT1
12
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8.9VEGFC, FLT1, VEGFA, PGF
13
Hide members
8.9FLT1, VEGFA, VEGFC, PGF
14
Hide members
8.9VEGFA, FLT1, VEGFC, PGF
15
Hide members
8.9PGF, FLT1, VEGFA, VEGFC
168.7REN, HIF1A, ANGPT2, VEGFC, FLT1
17
Hide members
8.5VEGFC, PGF, ANGPT2, ANGPT1, FLT1
18
Hide members
8.5FLT1, VEGFC, ANGPT1, ANGPT2, PGF
19
Hide members
8.5FLT1, VEGFC, PGF, ANGPT2, ANGPT1
20
Hide members
8.4FLT1, PGF, VEGFA, VEGFC, HIF1A
218.2PGF, ANGPT2, ANGPT1, VEGFC, FLT1, VEGFA
228.1VEGFA, HIF1A, ANGPT2, ANGPT1, FLT1, EDN1
23
Hide members
8.0FLT1, VEGFC, ANGPT1, ANGPT2, HIF1A, PGF

Compounds for genes affiliated with Twin Twin Transfusion Syndrome

Sources:
45Novoseek, 11DrugBank, 24HMDB, 50PharmGKB, 29IUPHAR, 60Tocris Bioscience
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Compounds related to Twin Twin Transfusion Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 151)
idCompoundScoreTop Affiliating Genes
1mannitol45 1111.4ALB
2toki-shakuyaku-san4510.1EDN1, NPPA, REN
3uric acid45 2411.1CST3, AFP, B2M
4pge24510.0REN, VEGFC, VEGFA
5p-aminohippuric acid4510.0NPPA, ALB, B2M
6ramipril45 1110.9CST3, REN, ALB, NPPA
7urodilatin459.9EDN1, NPPA, REN
8lisinopril45 11 2411.8REN, ALB, NPPA, VEGFA
9perindopril45 50 1111.8VEGFA, ALB, NPPA, REN
10omapatrilat459.8REN, EDN1, NPPA
11carvedilol45 50 29 1112.7VEGFA, EDN1, NPPA, REN
1251-cr-edta459.7ALB, CST3, NPPA, B2M, REN
13sodium45 2410.7AMBP, AFP, REN, EDN1
14cilazapril45 1110.7EDN1, REN, NPPA
15iohexol459.6CST3, B2M, ALB, AMBP
16candesartan45 29 1111.5HIF1A, REN, ALB, VEGFA
17ang ii459.5NPPA, VEGFA, EDN1, REN
18potassium45 11 2411.5REN, ANGPT1, AFP, AMBP
19digoxin45 50 60 11 2413.5NPPA, HIF1A, CST3, REN
20trandolapril45 1110.5NPPA, REN, EDN1
21nitroglycerin45 1110.4EDN1, B2M, NPPA, REN, HIF1A
22captopril45 29 50 60 1113.4REN, B2M, ALB, CST3, EDN1, NPPA
23hanp459.4EDN1, NPPA, AMBP, B2M, REN
24kininogen459.4ALB, REN, NPPA, AMBP, CST3
25enalapril45 50 1111.4AMBP, NPPA, EDN1, REN, ALB
26sodium nitroprusside459.3NPPA, EDN1, B2M, HIF1A, REN
27celecoxib45 60 29 50 11 2414.3ALB, REN, HIF1A, ANGPT2, VEGFA
28urea45 11 2411.2AMBP, AFP, B2M, CST3, ALB
29inulin459.2AMBP, CST3, NPPA, B2M, REN, ALB
30nifedipine45 50 29 1112.2EDN1, B2M, AMBP, REN, NPPA
31matrigel459.1FLT1, HIF1A, ANGPT1, PGF
32sunitinib45 50 1111.1PGF, HIF1A, VEGFA, FLT1
33fibrinogen458.7AMBP, AFP, ANGPT1, ANGPT2, ALB, CST3
34glyceraldehyde 3-phosphate458.7B2M, FLT1, HIF1A, ANGPT2, ANGPT1, VEGFC
35oxygen45 249.7ANGPT2, ANGPT1, VEGFC, AFP, PGF, FLT1
36prostacyclin458.6VEGFA, ANGPT1, FLT1, EDN1, NPPA, PGF
37cyclosporin a45 29 6010.5ANGPT2, EDN1, B2M, ANGPT1, HIF1A, AMBP
38heparin45 29 11 2411.5AFP, VEGFA, PGF, FLT1, PAPPA
39doxorubicin45 50 1110.4HIF1A, FLT1, ANGPT1, AFP, VEGFA, B2M
40cisplatin45 50 60 1111.4HIF1A, CST3, B2M, AFP, VEGFA, AMBP
41thymidine45 249.2VEGFC, HIF1A, FLT1, EDN1, ANGPT2, B2M
42dexamethasone45 50 29 1111.1HIF1A, PAPPA, REN, AFP, VEGFA, VEGFC
43steroid457.8B2M, REN, ANGPT1, AMBP, AFP, ANGPT2
44nitric oxide45 11 249.7EDN1, HIF1A, FLT1, ANGPT1, ANGPT2, REN
45paraffin457.7FLT1, AFP, B2M, HIF1A, VEGFA, VEGFC
46creatinine457.7AMBP, CST3, NPPA, FLT1, AFP, ANGPT2
47lipid457.0ALB, AMBP, CST3, AFP, VEGFC, PGF
48glucose456.7FLT1, AMBP, PAPPA, PGF, REN, CST3
49vegf455.9PAPPA, FLT1, AFP, EDN1, NPPA, CST3
50calcium45 50 11 248.9CST3, AMBP, NPPA, B2M, VEGFC, EDN1

GO Terms for genes affiliated with Twin Twin Transfusion Syndrome

Sources:
16Gene Ontology
See all sources

Cellular components related to Twin Twin Transfusion Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.5ALB, VEGFC, VEGFA
2extracellular regionGO:0055765.5ALB, AMBP, PAPPA, PGF, REN, ANGPT2
3extracellular spaceGO:0056155.0PGF, ALB, REN, ANGPT2, ANGPT1, VEGFC

Biological processes related to Twin Twin Transfusion Syndrome according to GeneCards/GeneDecks:

(show all 27)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of chemokine-mediated signaling pathwayGO:07010110.1HIF1A, EDN1
2positive regulation of mast cell chemotaxisGO:06075410.1VEGFC, VEGFA
3Tie signaling pathwayGO:04801410.1ANGPT2, ANGPT1
4glomerulus vasculature developmentGO:07201210.1ANGPT2, ANGPT1
5positive regulation of transcription from RNA polymerase II promoter in response to hypoxiaGO:06141910.0VEGFA, HIF1A
6positive regulation of endothelial cell migrationGO:0105959.9VEGFA, ANGPT1, EDN1
7positive regulation of receptor biosynthetic processGO:0108709.8EDN1, HIF1A
8induction of positive chemotaxisGO:0509309.8VEGFA, VEGFC
9patterning of blood vesselsGO:0015699.8FLT1, EDN1, VEGFA
10positive regulation of blood vessel endothelial cell migrationGO:0435369.8ANGPT1, VEGFA, VEGFC
11positive chemotaxisGO:0509189.8VEGFC, ANGPT1, VEGFA
12positive regulation of MAP kinase activityGO:0434069.8VEGFA, FLT1, EDN1
13positive regulation of protein autophosphorylationGO:0319549.7VEGFA, VEGFC
14positive regulation of neuroblast proliferationGO:0020529.7VEGFA, HIF1A, VEGFC
15positive regulation of vascular endothelial growth factor receptor signaling pathwayGO:0309499.7FLT1, VEGFA, HIF1A
16platelet degranulationGO:0025769.5ALB, VEGFC, VEGFA
17positive regulation of cell divisionGO:0517819.5VEGFC, PGF, VEGFA
18sprouting angiogenesisGO:0020409.5PGF, ANGPT1, FLT1
19dopaminergic neuron differentiationGO:0715429.4HIF1A, VEGFA
20positive regulation of endothelial cell proliferationGO:0019389.4HIF1A, VEGFA, PGF
21vascular endothelial growth factor receptor signaling pathwayGO:0480109.3VEGFA, VEGFC, FLT1, PGF
22angiogenesisGO:0015259.2ANGPT2, HIF1A, VEGFA, VEGFC
23response to hypoxiaGO:0016669.0VEGFA, EDN1, ANGPT2, HIF1A, PGF
24blood coagulationGO:0075969.0ALB, ANGPT2, VEGFA, VEGFC, ANGPT1
25positive regulation of cell proliferationGO:0082848.8FLT1, EDN1, PGF, VEGFC, VEGFA
26positive regulation of angiogenesisGO:0457668.8HIF1A, ANGPT2, VEGFA, FLT1, PGF
27female pregnancyGO:0075658.7PGF, NPPA, AMBP, PAPPA

Products for genes affiliated with Twin Twin Transfusion Syndrome

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Sources for Twin Twin Transfusion Syndrome

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet