Aliases & Classifications for Tympanosclerosis

MalaCards integrated aliases for Tympanosclerosis:

Name: Tympanosclerosis 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:1214
ICD9CM 34 385.09
SNOMED-CT 64 111540000
ICD10 32 H74.0

Summaries for Tympanosclerosis

MalaCards based summary : Tympanosclerosis is related to otitis media and middle ear disease. An important gene associated with Tympanosclerosis is TLR4 (Toll Like Receptor 4), and among its related pathways/superpathways are PEDF Induced Signaling and NF-KappaB Family Pathway. Affiliated tissues include bone, and related phenotypes are cardiovascular system and adipose tissue

Wikipedia : 72 Tympanosclerosis (also known as myringosclerosis or intratympanic tympanosclerosis) is a condition... more...

Related Diseases for Tympanosclerosis

Diseases related to Tympanosclerosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 76)
# Related Disease Score Top Affiliating Genes
1 otitis media 30.5 TLR4 TNF
2 middle ear disease 30.0 TLR4 TNF
3 chlamydia 29.2 NOS2 TLR4 TNF
4 deafness, progressive, with stapes fixation 11.0
5 bone fracture 10.3 BMP2 TLR4
6 spondylarthropathy 10.2 TLR4 TNF
7 trench fever 10.2 TLR4 TNF
8 anterior uveitis 10.2 TLR4 TNF
9 chronic pyelonephritis 10.2 CALCA TLR4
10 penicilliosis 10.2 TLR4 TNF
11 alveolar echinococcosis 10.2 TLR4 TNF
12 scrub typhus 10.2 TLR4 TNF
13 q fever 10.2 TLR4 TNF
14 perinatal necrotizing enterocolitis 10.2 TLR4 TNF
15 ileitis 10.2 TLR4 TNF
16 uterine anomalies 10.2 TLR4 TNF
17 legionellosis 10.2 TLR4 TNF
18 keratoconjunctivitis sicca 10.2 TLR4 TNF
19 bacterial vaginosis 10.2 TLR4 TNF
20 glucocorticoid-induced osteoporosis 10.2 BMP2 CALCA
21 idiopathic neutropenia 10.2 TLR4 TNF
22 paracoccidioidomycosis 10.2 TLR4 TNF
23 melioidosis 10.2 TLR4 TNF
24 degenerative disc disease 10.2 BMP2 CALCA
25 brucellosis 10.2 TLR4 TNF
26 pyelonephritis 10.2 TLR4 TNF
27 typhoid fever 10.2 TLR4 TNF
28 erysipelas 10.2 CALCA TNF
29 aggressive periodontitis 10.1 TLR4 TNF
30 chorioamnionitis 10.1 TLR4 TNF
31 filariasis 10.1 TLR4 TNF
32 bone resorption disease 10.1 BMP2 CALCA
33 lymphadenitis 10.1 TLR4 TNF
34 cutaneous leishmaniasis 10.1 TLR4 TNF
35 bone remodeling disease 10.1 BMP2 CALCA
36 complex regional pain syndrome 10.1 CALCA TNF
37 primary bacterial infectious disease 10.1 TLR4 TNF
38 cholesteatoma 10.1
39 headache 10.1 CALCA TNF
40 cystitis 10.1 TLR4 TNF
41 toxoplasmosis 10.1 TLR4 TNF
42 helicobacter pylori infection 10.1 TLR4 TNF
43 osteomyelitis 10.1 BMP2 TNF
44 toxic shock syndrome 10.1 TLR4 TNF
45 intestinal disease 10.0 TLR4 TNF
46 enterobiasis 10.0 NOS2 TLR4
47 respiratory system disease 10.0 TLR4 TNF
48 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.0
49 pneumonia 10.0
50 bronchiolitis 9.9 TLR4 TNF

Graphical network of the top 20 diseases related to Tympanosclerosis:



Diseases related to Tympanosclerosis

Symptoms & Phenotypes for Tympanosclerosis

MGI Mouse Phenotypes related to Tympanosclerosis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.77 SOD2 TLR4 TNF BMP2 NOS2
2 adipose tissue MP:0005375 9.71 TLR4 TNF NOS2 SOD2
3 digestive/alimentary MP:0005381 9.62 TLR4 TNF BMP2 NOS2
4 liver/biliary system MP:0005370 9.56 SOD2 TLR4 TNF NOS2
5 muscle MP:0005369 9.46 SOD2 TLR4 TNF NOS2
6 neoplasm MP:0002006 9.26 SOD2 TLR4 TNF NOS2
7 reproductive system MP:0005389 9.02 TLR4 TNF BMP2 NOS2 SOD2

Drugs & Therapeutics for Tympanosclerosis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Gas Supply, Demand and Middle Ear Gas Balance: Specific Aim 3c Completed NCT00422851

Search NIH Clinical Center for Tympanosclerosis

Genetic Tests for Tympanosclerosis

Anatomical Context for Tympanosclerosis

MalaCards organs/tissues related to Tympanosclerosis:

38
Bone

Publications for Tympanosclerosis

Articles related to Tympanosclerosis:

(show top 50) (show all 149)
# Title Authors Year
1
Stapes Release in Tympanosclerosis. ( 29210944 )
2018
2
Possible role of Dickkopf-1 protein in the pathogenesis of tympanosclerosis in a rat model. ( 28807065 )
2017
3
The effect of caffeic acid phenethyl ester (CAPE) on tympanosclerosis. ( 28576521 )
2017
4
Gene expression profile of collagen types, osteopontin in the tympanic membrane of patients with tympanosclerosis. ( 29068597 )
2017
5
Tympanosclerosis Presenting as Mass: Workup and Differential. ( 27656306 )
2016
6
Neuroglial Choristoma of the Middle Ear with Massive Tympanosclerosis: A Case Report and Literature Review. ( 27942605 )
2016
7
The effect of melatonin and vitamin C treatment on the experimentally induced tympanosclerosis: study in rats. ( 27484331 )
2016
8
Ectopic Mineralization and Conductive Hearing Loss in Enpp1asj Mutant Mice, a New Model for Otitis Media and Tympanosclerosis. ( 27959908 )
2016
9
Genetic polymorphisms affecting antioxidant enzymes are present in tympanosclerosis patients. ( 27534583 )
2016
10
Correlation Between Tympanosclerosis and Helicobacter pylori. ( 26568799 )
2015
11
Increased carotid artery intima-media thickness in patients with tympanosclerosis: Common risk factors with atherosclerosis? ( 25835276 )
2015
12
Does systemic clarithromycin therapy have an inhibitory effect on tympanosclerosis? An experimental animal study. ( 25619629 )
2015
13
An Analysis of Surgical Treatment Results of Patients With Tympanosclerosis. ( 26517462 )
2015
14
Efficacy of pre-operative computed tomography evaluation of the tympanic cavity for hearing improvement after stapes surgery for tympanosclerosis with stapes fixation. ( 25706157 )
2015
15
Role of Chlamydia pneumoniae and Helicobacteria pylori in the development of tympanosclerosis. ( 25956614 )
2015
16
Manubrio-stapedioplasty: new surgical technique for malleus and incus fixation due to tympanosclerosis. ( 25883094 )
2015
17
Combining Use of Captopril and Losartan Attenuates the Progress of Streptococcus pneumoniae-Induced Tympanosclerosis through the Suppression of TGF-I^1 Expression. ( 25360706 )
2014
18
PAI-1 inhibits development of chronic otitis media and tympanosclerosis in a mouse model of otitis media. ( 25399881 )
2014
19
Immunohistochemical investigation of inducible nitric oxide synthase, osteopontin, and calcium-sensing receptor in a myringosclerosis/tympanosclerosis model. ( 24136309 )
2014
20
Surgery of isolated malleus fixation due to tympanosclerosis. ( 25503358 )
2014
21
The effect of stapes fixation on hearing results in tympanosclerosis treated by mobilization. ( 25472817 )
2014
22
Morphological Alterations in the Tympanic Membrane Affected by Tympanosclerosis: Ultrastructural Study. ( 24134073 )
2013
23
[Assessment of Tumor Necrosis Factor alpha gene expression profile in selected structures of middle ear in patients with tympanosclerosis]. ( 23164102 )
2012
24
Experience with the Vibrant Soundbridge RW-Coupler for round window Vibroplasty with tympanosclerosis. ( 22385350 )
2012
25
Expressions of TGF-I^1 and MMP-9 in a guinea pig model of tympanosclerosis: possible role in the pathogenesis of this disorder. ( 22777961 )
2012
26
Serum matrix metalloproteinases and tympanosclerosis. ( 20955636 )
2011
27
Could Helicobacter pylori play a role in the aetiopathogenesis of tympanosclerosis? ( 21888743 )
2011
28
Evaluation of the polymorphism in the Toll-like receptor 4 (TLR4) genes of tympanosclerosis patients. ( 19398177 )
2010
29
Clinical analysis of intratympanic tympanosclerosis: etiology, ossicular chain findings, and hearing results of surgery. ( 19685361 )
2010
30
Is there any relation between coronary atherosclerosis and tympanosclerosis? ( 20382609 )
2010
31
Tympanosclerosis and our surgical results. ( 19771442 )
2010
32
[Expression and localization of macrophages and BMP2 in mucosa of tympanosclerosis]. ( 19670606 )
2009
33
Hearing results of surgery for tympanosclerosis. ( 18704475 )
2009
34
A computational method for the semi-automated quantitative analysis of tympanic membrane perforations and tympanosclerosis. ( 19643399 )
2009
35
Stapedectomy in tympanosclerosis, hearing results. ( 18454228 )
2008
36
Does exogenous nitric oxide influence tympanosclerosis? An experimental study. ( 18945497 )
2008
37
The effect of stapes mobility on hearing outcome and which procedure to choose in fixed stapes in children tympanosclerosis. ( 18394718 )
2008
38
Analysis of long-term hearing after tympanosclerosis with total/partial stapedectomy and prosthesis used. ( 18607937 )
2008
39
The effect of topical doxycycline in the prevention of experimental tympanosclerosis. ( 18388770 )
2008
40
Evaluation of plasma fibronectine level as a probable indicator for tympanosclerosis. ( 17470306 )
2008
41
Topical application of calcium channel blockers to reduce the progression of experimentally induced myringosclerosis and tympanosclerosis. ( 18176349 )
2008
42
Malleostapedotomy in tympanosclerosis patients. ( 17524174 )
2007
43
Management of tympanosclerosis with ossicular fixation: review and presentation of long-term results of 30 new cases. ( 17963670 )
2007
44
Tympanosclerosis revisited. ( 23120263 )
2006
45
Influence of hypercalcemia in the formation of tympanosclerosis in rats. ( 16371843 )
2006
46
Tympanosclerosis involving the ossicular chain: mobility of the stapes in association with hearing results. ( 16923708 )
2006
47
Possible relationship between tympanosclerosis and atherosclerosis. ( 15267174 )
2004
48
An analysis of the single-stage tympanoplasty with over-underlay grafting in tympanosclerosis. ( 15129093 )
2004
49
Comparison of free radicals and antioxidant enzymes in chronic otitis media with and without tympanosclerosis. ( 14710000 )
2004
50
Is carotid stenosis correlated with tympanosclerosis. ( 15507892 )
2004

Variations for Tympanosclerosis

Expression for Tympanosclerosis

Search GEO for disease gene expression data for Tympanosclerosis.

Pathways for Tympanosclerosis

Pathways related to Tympanosclerosis according to GeneCards Suite gene sharing:

(show all 23)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.23 BMP2 NOS2 SOD2 TLR4 TNF
2
Show member pathways
12.37 BMP2 TLR4 TNF
3
Show member pathways
12.19 NOS2 TLR4 TNF
4
Show member pathways
11.93 NOS2 TLR4 TNF
5
Show member pathways
11.9 NOS2 TLR4 TNF
6 11.89 NOS2 TLR4 TNF
7
Show member pathways
11.8 NOS2 TLR4 TNF
8 11.76 NOS2 TLR4 TNF
9 11.58 NOS2 TLR4 TNF
10 11.54 BMP2 TNF
11 11.52 NOS2 SOD2
12 11.44 TLR4 TNF
13 11.42 NOS2 TLR4 TNF
14 11.39 CALCA TNF
15
Show member pathways
11.38 NOS2 TNF
16 11.31 TLR4 TNF
17 11.29 TLR4 TNF
18 11.24 TLR4 TNF
19 11.21 NOS2 TLR4 TNF
20 11.19 CALCA TNF
21 11.05 TLR4 TNF
22 10.95 NOS2 TLR4 TNF
23 10.48 NOS2 TLR4 TNF

GO Terms for Tympanosclerosis

Biological processes related to Tympanosclerosis according to GeneCards Suite gene sharing:

(show all 36)
# Name GO ID Score Top Affiliating Genes
1 regulation of receptor activity GO:0010469 9.83 BMP2 CALCA TNF
2 positive regulation of gene expression GO:0010628 9.81 BMP2 TLR4 TNF
3 negative regulation of gene expression GO:0010629 9.74 BMP2 NOS2 TNF
4 defense response to bacterium GO:0042742 9.73 NOS2 TLR4 TNF
5 defense response to Gram-negative bacterium GO:0050829 9.67 NOS2 TLR4
6 cellular response to organic cyclic compound GO:0071407 9.67 BMP2 TNF
7 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.67 BMP2 TLR4 TNF
8 apoptotic signaling pathway GO:0097190 9.66 TLR4 TNF
9 regulation of inflammatory response GO:0050727 9.66 TLR4 TNF
10 positive regulation of JNK cascade GO:0046330 9.65 TLR4 TNF
11 regulation of insulin secretion GO:0050796 9.65 NOS2 TNF
12 regulation of blood pressure GO:0008217 9.64 CALCA SOD2
13 I-kappaB kinase/NF-kappaB signaling GO:0007249 9.64 TLR4 TNF
14 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.63 SOD2 TNF
15 response to lipopolysaccharide GO:0032496 9.63 NOS2 SOD2 TLR4
16 negative regulation of fat cell differentiation GO:0045599 9.62 SOD2 TNF
17 positive regulation of interleukin-6 production GO:0032755 9.62 TLR4 TNF
18 positive regulation of interferon-gamma production GO:0032729 9.61 TLR4 TNF
19 response to bacterium GO:0009617 9.61 NOS2 TLR4
20 response to hypoxia GO:0001666 9.61 BMP2 NOS2 SOD2
21 lipopolysaccharide-mediated signaling pathway GO:0031663 9.6 TLR4 TNF
22 negative regulation of blood pressure GO:0045776 9.59 CALCA NOS2
23 negative regulation of interleukin-6 production GO:0032715 9.58 TLR4 TNF
24 positive regulation of blood vessel diameter GO:0097755 9.58 CALCA NOS2
25 positive regulation of NF-kappaB import into nucleus GO:0042346 9.55 TLR4 TNF
26 vasodilation GO:0042311 9.54 CALCA SOD2
27 cellular response to lipopolysaccharide GO:0071222 9.54 NOS2 TLR4 TNF
28 superoxide metabolic process GO:0006801 9.52 NOS2 SOD2
29 negative regulation of osteoclast differentiation GO:0045671 9.51 CALCA TLR4
30 activation of MAPK activity GO:0000187 9.5 BMP2 TLR4 TNF
31 positive regulation of chemokine production GO:0032722 9.48 TLR4 TNF
32 inflammatory response GO:0006954 9.46 BMP2 CALCA TLR4 TNF
33 positive regulation of ossification GO:0045778 9.4 BMP2 CALCA
34 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.26 TLR4 TNF
35 positive regulation of nitric oxide biosynthetic process GO:0045429 9.13 SOD2 TLR4 TNF
36 positive regulation of interleukin-8 production GO:0032757 8.8 CALCA TLR4 TNF

Molecular functions related to Tympanosclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 receptor binding GO:0005102 8.92 BMP2 CALCA NOS2 TLR4

Sources for Tympanosclerosis

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9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
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70 UMLS via Orphanet
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