MCID: TYM001
MIFTS: 34

Tympanosclerosis malady

Ear category

Summaries for Tympanosclerosis

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Tympanosclerosis (also known as myringosclerosis or intratympanic tympanosclerosis) is a condition... more...

MalaCards: Tympanosclerosis is related to atherosclerosis and carotid stenosis. An important gene associated with Tympanosclerosis is BMP2 (bone morphogenetic protein 2), and among its related pathways are BDNF signaling pathway and Transcription Role of VDR in regulation of genes involved in osteoporosis. The compounds zoledronic acid and alendronate have been mentioned in the context of this disorder. Related mouse phenotypes are hearing/vestibular/ear and skeleton.

Aliases & Classifications for Tympanosclerosis

Sources:
8Disease Ontology, 61UMLS, 27ICD9CM, 57SNOMED-CT, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Ear


Aliases & Descriptions:

tympanosclerosis 8 61


External Ids:

Disease Ontology8 DOID:1214
ICD9CM27 385.09
SNOMED-CT57 111540000
ICD1025 H74.0

Related Diseases for Tympanosclerosis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Tympanosclerosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 48)
idRelated DiseaseScoreTop Affiliating Genes
1atherosclerosis10.2
2carotid stenosis10.0
3hypercalcemia10.0
4suppurative otitis media10.0
5deafness, progressive with stapes fixation10.0
6hemochromatosis10.0BMP2
7diarrhea10.0CALCA
8trigeminal neuralgia10.0BMP2
9hypertension10.0CALCA
10sarcoma10.0BMP2
11ankylosis10.0BMP2
12pancreatic cancer10.0BMP2
13root resorption10.0BMP2
14thyroiditis10.0CALCA
15periodontitis10.0TLR4
16osteomyelitis10.0BMP2
17pyelonephritis10.0TLR4
18osteonecrosis10.0BMP2
19inflammatory bowel disease10.0TLR4
20insulin resistance10.0TLR4
21calcinosis10.0SPP1
22rhabdoid tumor10.0SPP1
23nephrolithiasis10.0SPP1
24galactosemia10.0TLR4
25diabetes mellitus10.0BMP2, CALCA
26primary hyperoxaluria10.0SPP1
27adenoma10.0CALCA, TLR4
28uremia10.0SPP1
29arteriosclerosis10.0SPP1
30myeloma10.0SPP1, BMP2
31aortic valve stenosis10.0SPP1, BMP2
32hyperphosphatemia10.0SPP1, BMP2
33bone carcinoma10.0BMP2, SPP1
34ovarian cancer10.0SPP1, BMP2
35adenocarcinoma10.0SPP1, BMP2
36papillary thyroid carcinoma10.0CALCA, SPP1
37periodontal disease10.0TLR4, SPP1
38prostate cancer10.0SPP1, BMP2
39osteosarcoma10.0BMP2, SPP1
40arthritis10.0BMP2, TLR4, CALCA
41secondary syphilis10.0SPP1, BMP2, CALCA
42osteoarthritis10.0SPP1, BMP2, CALCA
43osteoporosis10.0SPP1, BMP2, CALCA
44rheumatoid arthritis10.0SPP1, BMP2, TLR4
45stomach cancer10.0TLR4, BMP2, SPP1
46melanoma10.0TLR4, BMP2, SPP1
47congenital heart defect10.0SPP1, TLR4
48lung cancer10.0TLR4, BMP2, SPP1

Graphical network of the top 20 diseases related to Tympanosclerosis:



Diseases related to tympanosclerosis

Clinical Features for Tympanosclerosis

Drugs & Therapeutics for Tympanosclerosis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Tympanosclerosis

Drug clinical trials:

Search ClinicalTrials for Tympanosclerosis

Search NIH Clinical Center for Tympanosclerosis

Search CenterWatch for Tympanosclerosis

Genetic Tests for Tympanosclerosis

Anatomical Context for Tympanosclerosis

Animal Models for Tympanosclerosis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Tympanosclerosis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053779.2TLR4, BMP2
2MP:00053909.2SPP1, BMP2
3MP:00020068.5SPP1, TLR4, CALCA
4MP:00053858.0SPP1, BMP2, TLR4, CALCA
5MP:00036317.7SPP1, BMP2, TLR4, CALCA

Publications for Tympanosclerosis

Sources:
51PubMed
See all sources

Articles related to Tympanosclerosis:

(show top 50)    (show all 128)
idTitleAuthorsYear
1
Immunohistochemical investigation of inducible nitric oxide synthase, osteopontin, and calcium-sensing receptor in a myringosclerosis/tympanosclerosis model. (24136309)
2014
2
Morphological Alterations in the Tympanic Membrane Affected by Tympanosclerosis: Ultrastructural Study. (24134073)
2013
3
Expressions of TGF-I^1 and MMP-9 in a guinea pig model of tympanosclerosis: possible role in the pathogenesis of this disorder. (22777961)
2012
4
Serum matrix metalloproteinases and tympanosclerosis. (20955636)
2011
5
Evaluation of the polymorphism in the Toll-like receptor 4 (TLR4) genes of tympanosclerosis patients. (19398177)
2010
6
Hearing results of surgery for tympanosclerosis. (18704475)
2009
7
Expression and localization of macrophages and BMP2 in mucosa of tympanosclerosis]. (19670606)
2009
8
The effect of topical doxycycline in the prevention of experimental tympanosclerosis. (18388770)
2008
9
Analysis of long-term hearing after tympanosclerosis with total/partial stapedectomy and prosthesis used. (18607937)
2008
10
The effect of stapes mobility on hearing outcome and which procedure to choose in fixed stapes in children tympanosclerosis. (18394718)
2008
11
Topical application of calcium channel blockers to reduce the progression of experimentally induced myringosclerosis and tympanosclerosis. (18176349)
2008
12
Influence of hypercalcemia in the formation of tympanosclerosis in rats. (16371843)
2006
13
Tympanosclerosis involving the ossicular chain: mobility of the stapes in association with hearing results. (16923708)
2006
14
Possible relationship between tympanosclerosis and atherosclerosis. (15267174)
2004
15
Tympanosclerosis: long-term hearing results after ossicular reconstruction. (11956534)
2002
16
Possible inflammatory mediators in tympanosclerosis development. (11955606)
2002
17
Tympanosclerosis in the rat tympanic membrane: an experimental study. (12352683)
2002
18
Tympanosclerosis (cosmetic) and retraction. (11913052)
2002
19
Long-term ventilating tube with tympanosclerosis. (11011482)
2000
20
Tympanosclerosis. (10665186)
2000
21
Surgical treatment of tympanosclerosis. (10993449)
2000
22
Extensive tympanosclerosis with a fixed malleus. (10355190)
1999
23
Tympanosclerosis. (10503596)
1999
24
Extensive tympanosclerosis and a short incus. (10224694)
1999
25
An immunohistochemical study of inducible nitric oxide synthase in the rat middle ear, with reference to tympanosclerosis. (10478599)
1999
26
Serous otitis media with tympanosclerosis and healed neomembrane. (9787511)
1998
27
Surgical treatment of tympanosclerosis. (7718221)
1995
28
Tympanosclerosis in the tympanic membrane: influence on outcome of myringoplasty. (8572148)
1995
29
Tympanosclerosis of the stapes: hearing results for various surgical treatments. (1437202)
1992
30
Myringitis bullosa haemorrhagica: clinical course influenced by tympanosclerosis. (1556493)
1992
31
Development of tympanosclerosis in children with otitis media with effusion and ventilation tubes. (1919311)
1991
32
Tympanosclerosis: a scanning electron microscopic study. (2920452)
1989
33
An experimental model for tympanosclerosis. A preliminary report. (3400457)
1988
34
The significance of calcium antagonists in rat experimental tympanosclerosis. (3551898)
1987
35
Prospective study of tympanosclerosis developing after grommet insertion. (6470572)
1984
36
Tympanosclerosis of the ear drum in secretory otitis media. (6598264)
1984
37
Tympanosclerosis. (6582197)
1983
38
Tympanosclerosis and concentric lamellated bodies in middle ear. (6310934)
1983
39
Clinicopathologic studies in tympanosclerosis. (7055238)
1982
40
The ultrastructure of tympanosclerosis. The source of the matrix vesicles and the pattern of calcospherules. (7304723)
1981
41
Tympanosclerosis. (7318705)
1981
42
The role of matrix vesicles in the pathogenesis of tympanosclerosis. (7405576)
1980
43
Tympanosclerosis. An electron microscopic study of matrix vesicles. (6778316)
1980
44
Histopathogenesis of tympanosclerosis. (429881)
1979
45
Histology of tympanosclerosis. (4110701)
1972
46
The pathology of tympanosclerosis. (5416456)
1970
47
Tympanosclerosis. Electron microscopic study. (4908183)
1969
48
Tympanosclerosis. (13911558)
1962
49
Tympanosclerosis--a revived clinocopathologic entity. (13904842)
1961
50
Tympanosclerosis. (13307111)
1956

Genetic Variations for Tympanosclerosis

Expression for genes affiliated with Tympanosclerosis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Tympanosclerosis

Search GEO for disease gene expression data for Tympanosclerosis.

Pathways for genes affiliated with Tympanosclerosis

Sources:
38NCBI BioSystems Database, 12EMD Millipore
See all sources

Pathways related to Tympanosclerosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1SPP1, BMP2
2
Transcription Role of VDR in regulation of genes involved in osteoporosis
Hide members
9.1SPP1, CALCA

Compounds for genes affiliated with Tympanosclerosis

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 29IUPHAR, 24HMDB, 60Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Tympanosclerosis according to GeneCards/GeneDecks:

(show all 45)
idCompoundScoreTop Affiliating Genes
1zoledronic acid459.8CALCA, BMP2
2alendronate45 50 1111.8BMP2, CALCA
3raloxifene45 29 50 1112.8BMP2, CALCA
4fibroin459.6SPP1, BMP2
5methylmethacrylate459.6BMP2, SPP1
6alizarin459.5SPP1, BMP2
7chitosan459.5SPP1, BMP2
8titanium459.5SPP1, BMP2
9atorvastatin45 50 29 11 2413.5BMP2, TLR4
10alginate459.5BMP2, SPP1
11ibmx45 29 6011.5BMP2, CALCA
1225-hydroxyvitamin d459.5SPP1, CALCA
13phosphorus459.5SPP1, CALCA
14creatinine459.5SPP1, BMP2
15fluoride459.5CALCA, SPP1
16hydroxyapatite459.4SPP1, BMP2
17neomycin459.4SPP1, BMP2
18polyethylene glycol459.4BMP2, SPP1
19infliximab45 50 1111.4SPP1, TLR4
20simvastatin45 50 60 29 11 2414.3BMP2, TLR4
21nifedipine45 50 29 1112.3SPP1, BMP2
22latex459.3SPP1, TLR4
23nitric oxide45 11 2411.0BMP2, TLR4, CALCA
241,25 dihydroxy vitamin d3459.0SPP1, BMP2, CALCA
25indomethacin45 60 29 1112.0CALCA, BMP2, SPP1
26testosterone45 60 11 2411.9CALCA, BMP2, SPP1
27tgf beta1458.9TLR4, BMP2, SPP1
28tacrolimus45 50 1110.9SPP1, BMP2, TLR4
29sb 20358045 609.9SPP1, BMP2, TLR4
30wortmannin458.9TLR4, BMP2, SPP1
31actinomycin d458.9SPP1, BMP2, TLR4
32genistein45 29 60 2 11 2413.9SPP1, BMP2, TLR4
33cholesterol45 29 11 2411.8TLR4, BMP2, SPP1
34dexamethasone45 50 29 1111.8SPP1, BMP2, TLR4
35estrogen458.7CALCA, BMP2, SPP1
36alanine458.7TLR4, BMP2, SPP1
37retinoic acid45 249.5SPP1, BMP2, TLR4
38calcitriol45 60 11 2411.4SPP1, BMP2, TLR4, CALCA
39vitamin d458.4CALCA, TLR4, BMP2, SPP1
40cyclosporin a45 29 6010.4SPP1, BMP2, TLR4, CALCA
41lactate458.4CALCA, TLR4, BMP2, SPP1
42cysteine458.4TLR4, BMP2, SPP1
43vegf458.4SPP1, BMP2, TLR4, CALCA
44calcium45 50 11 2411.3SPP1, BMP2, TLR4, CALCA
45glucose458.2SPP1, BMP2, TLR4

GO Terms for genes affiliated with Tympanosclerosis

Sources:
16Gene Ontology
See all sources

Cellular components related to Tympanosclerosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.6SPP1, BMP2, CALCA

Biological processes related to Tympanosclerosis according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of ossificationGO:0457789.6BMP2, CALCA
2negative regulation of osteoclast differentiationGO:0456719.5TLR4, CALCA
3positive regulation of interleukin-8 productionGO:0327579.4TLR4, CALCA
4positive regulation of ERK1 and ERK2 cascadeGO:0703749.3BMP2, TLR4
5embryo implantationGO:0075669.1SPP1, CALCA
6activation of MAPK activityGO:0001879.0BMP2, TLR4
7osteoblast differentiationGO:0016499.0SPP1, BMP2
8inflammatory responseGO:0069548.7CALCA, BMP2, SPP1

Products for genes affiliated with Tympanosclerosis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Tympanosclerosis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet