MCID: TYM001
MIFTS: 39

Tympanosclerosis malady

Ear diseases category

Summaries for Tympanosclerosis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Tympanosclerosis (also known as myringosclerosis or intratympanic tympanosclerosis) is a condition... more...

MalaCards: Tympanosclerosis is related to otitis media and cholesteatoma. An important gene associated with Tympanosclerosis is BMP2 (bone morphogenetic protein 2), and among its related pathways are BDNF signaling pathway and Transcription Role of VDR in regulation of genes involved in osteoporosis. The compounds zoledronic acid and alendronate have been mentioned in the context of this disorder. Affiliated tissues include bone, and related mouse phenotypes are hearing/vestibular/ear and skeleton.

Aliases & Classifications for Tympanosclerosis

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Sources:
8Disease Ontology, 60UMLS, 27ICD9CM, 56SNOMED-CT, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Ear diseases


Aliases & Descriptions:

tympanosclerosis 8 60


External Ids:

Disease Ontology8 DOID:1214
ICD9CM27 385.09
SNOMED-CT56 111540000
ICD1025 H74.0

Related Diseases for Tympanosclerosis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Tympanosclerosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 53)
idRelated DiseaseScoreTop Affiliating Genes
1otitis media10.4
2cholesteatoma10.3
3atherosclerosis10.1
4hemochromatosis10.0BMP2
5diarrhea10.0CALCA
6trigeminal neuralgia10.0BMP2
7hypertension10.0CALCA
8sarcoma10.0BMP2
9ankylosis10.0BMP2
10pancreatic cancer10.0BMP2
11root resorption10.0BMP2
12thyroiditis10.0CALCA
13periodontitis10.0TLR4
14osteomyelitis10.0BMP2
15pyelonephritis10.0TLR4
16osteonecrosis10.0BMP2
17inflammatory bowel disease10.0TLR4
18insulin resistance10.0TLR4
19calcinosis10.0SPP1
20rhabdoid tumor10.0SPP1
21nephrolithiasis10.0SPP1
22galactosemia10.0TLR4
23diabetes mellitus10.0BMP2, CALCA
24primary hyperoxaluria10.0SPP1
25adenoma10.0TLR4, CALCA
26uremia10.0SPP1
27arteriosclerosis10.0SPP1
28myeloma10.0SPP1, BMP2
29aortic valve stenosis10.0SPP1, BMP2
30hyperphosphatemia10.0BMP2, SPP1
31bone carcinoma10.0BMP2, SPP1
32ovarian cancer10.0SPP1, BMP2
33adenocarcinoma10.0SPP1, BMP2
34papillary thyroid carcinoma10.0SPP1, CALCA
35periodontal disease10.0TLR4, SPP1
36prostate cancer10.0SPP1, BMP2
37osteosarcoma10.0SPP1, BMP2
38arthritis10.0TLR4, BMP2, CALCA
39secondary syphilis10.0SPP1, BMP2, CALCA
40osteoarthritis10.0SPP1, BMP2, CALCA
41osteoporosis10.0SPP1, CALCA, BMP2
42rheumatoid arthritis10.0TLR4, BMP2, SPP1
43stomach cancer10.0TLR4, BMP2, SPP1
44melanoma10.0TLR4, BMP2, SPP1
45congenital heart defect10.0TLR4, SPP1
46lung cancer10.0TLR4, SPP1, BMP2
47carotid stenosis10.0
48hypercalcemia10.0
49collagen disease10.0
50eustachian tube disease10.0

Graphical network of the top 20 diseases related to Tympanosclerosis:



Diseases related to tympanosclerosis

Clinical Features for Tympanosclerosis

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Drugs & Therapeutics for Tympanosclerosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Tympanosclerosis

Drug clinical trials:

Search ClinicalTrials for Tympanosclerosis

Search NIH Clinical Center for Tympanosclerosis

Search CenterWatch for Tympanosclerosis

Genetic Tests for Tympanosclerosis

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Anatomical Context for Tympanosclerosis

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Sources:
32MalaCards
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MalaCards organs/tissues related to Tympanosclerosis:

32
Bone

Animal Models for Tympanosclerosis or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Tympanosclerosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053779.2BMP2, TLR4
2MP:00053909.2SPP1, BMP2
3MP:00020068.5SPP1, TLR4, CALCA
4MP:00053858.0SPP1, BMP2, TLR4, CALCA
5MP:00036317.7TLR4, CALCA, SPP1, BMP2

Publications for Tympanosclerosis

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Sources:
50PubMed
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Articles related to Tympanosclerosis:

(show top 50)    (show all 128)
idTitleAuthorsYear
1
Experience with the Vibrant Soundbridge RW-Coupler for round window Vibroplasty with tympanosclerosis. (22385350)
2012
2
Serum matrix metalloproteinases and tympanosclerosis. (20955636)
2011
3
Is there any relation between coronary atherosclerosis and tympanosclerosis? (20382609)
2010
4
Hearing results of surgery for tympanosclerosis. (18704475)
2009
5
Expression and localization of macrophages and BMP2 in mucosa of tympanosclerosis]. (19670606)
2009
6
A computational method for the semi-automated quantitative analysis of tympanic membrane perforations and tympanosclerosis. (19643399)
2009
7
The effect of topical doxycycline in the prevention of experimental tympanosclerosis. (18388770)
2008
8
The effect of stapes mobility on hearing outcome and which procedure to choose in fixed stapes in children tympanosclerosis. (18394718)
2008
9
Topical application of calcium channel blockers to reduce the progression of experimentally induced myringosclerosis and tympanosclerosis. (18176349)
2008
10
Influence of hypercalcemia in the formation of tympanosclerosis in rats. (16371843)
2006
11
Tympanosclerosis revisited. (23120263)
2006
12
An analysis of the single-stage tympanoplasty with over-underlay grafting in tympanosclerosis. (15129093)
2004
13
Tympanosclerosis: long-term hearing results after ossicular reconstruction. (11956534)
2002
14
Experimental hematotympanum--aspects to the tympanosclerosis development. (12137309)
2002
15
Possible inflammatory mediators in tympanosclerosis development. (11955606)
2002
16
Tympanosclerosis (cosmetic) and retraction. (11913052)
2002
17
Sex distribution in children with tympanosclerosis after insertion of a tympanostomy tube. (11271428)
2001
18
Minimal tympanosclerosis (cosmetic). (11816885)
2001
19
Quantitation and prevalence of tympanosclerosis in a pediatric otolaryngology clinic. (11551611)
2001
20
Expression of osteopontin by exudate macrophages in inflammatory tissues of the middle ear: a possible association with development of tympanosclerosis. (11223300)
2001
21
Long-term ventilating tube with tympanosclerosis. (11011482)
2000
22
Tympanosclerosis. (10503596)
1999
23
Chronic suppurative otitis media with tympanosclerosis and cholesteatoma. (10429316)
1999
24
Extensive tympanosclerosis and a short incus. (10224694)
1999
25
An immunohistochemical study of inducible nitric oxide synthase in the rat middle ear, with reference to tympanosclerosis. (10478599)
1999
26
Human leucocyte antigens in tympanosclerosis. (9088683)
1997
27
Surgical treatment of tympanosclerosis. (7718221)
1995
28
Tympanic membrane perforation and tympanosclerosis with ossicular fixation. (8076533)
1994
29
Current considerations in the etiology and diagnosis of tympanosclerosis. (7718216)
1994
30
Dry central tympanic membrane perforation with tympanosclerosis. (8045229)
1994
31
Myringitis bullosa haemorrhagica: clinical course influenced by tympanosclerosis. (1556493)
1992
32
Development of tympanosclerosis in children with otitis media with effusion and ventilation tubes. (1919311)
1991
33
Aspirating middle ear effusions when inserting ventilation tubes: does it influence post-operative otorrhoea, tube obstruction or the development of tympanosclerosis? (1742892)
1991
34
An experimental model for tympanosclerosis. A preliminary report. (3400457)
1988
35
Type II collagen mediated autoimmune middle ear disease: eustachian tube disease, otitis media with effusion and tympanosclerosis. (3835948)
1985
36
Tympanosclerosis and concentric lamellated bodies in middle ear. (6310934)
1983
37
Clinicopathologic studies in tympanosclerosis. (7055238)
1982
38
The ultrastructure of tympanosclerosis. The source of the matrix vesicles and the pattern of calcospherules. (7304723)
1981
39
Tympanosclerosis. (7318705)
1981
40
Tympanosclerosis of the ear drum. A scanning electronmicroscopic study. (7257755)
1981
41
Problems of the stapes footplate associated with tympanosclerosis. (7347090)
1981
42
Tympanosclerosis. A theory of pathogenesis. (6775569)
1980
43
The role of matrix vesicles in the pathogenesis of tympanosclerosis. (7405576)
1980
44
Histopathogenesis of tympanosclerosis. (429881)
1979
45
Middle-ear mucosa in tympanosclerosis. (4818282)
1974
46
Histology of tympanosclerosis. (4110701)
1972
47
Tympanosclerosis. (5007958)
1972
48
Tympanosclerosis. (4996152)
1971
49
Tympanosclerosis. Electron microscopic study. (4908183)
1969
50
Tympanosclerosis. (5882309)
1965

Genetic Variations for Tympanosclerosis

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Expression for genes affiliated with Tympanosclerosis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Tympanosclerosis

Search GEO for disease gene expression data for Tympanosclerosis.

Pathways for genes affiliated with Tympanosclerosis

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Sources:
37NCBI BioSystems Database, 12EMD Millipore
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Pathways related to Tympanosclerosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1SPP1, BMP2
2
Transcription Role of VDR in regulation of genes involved in osteoporosis
Hide members
9.1SPP1, CALCA

Compounds for genes affiliated with Tympanosclerosis

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 28IUPHAR, 24HMDB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Tympanosclerosis according to GeneCards/GeneDecks:

(show all 45)
idCompoundScoreTop Affiliating Genes
1zoledronic acid449.8CALCA, BMP2
2alendronate44 49 1111.8CALCA, BMP2
3raloxifene44 28 49 1112.8CALCA, BMP2
4fibroin449.6SPP1, BMP2
5methylmethacrylate449.6SPP1, BMP2
6alizarin449.5SPP1, BMP2
7chitosan449.5BMP2, SPP1
8titanium449.5SPP1, BMP2
9atorvastatin44 49 28 11 2413.5TLR4, BMP2
10alginate449.5SPP1, BMP2
11ibmx44 28 5911.5CALCA, BMP2
1225-hydroxyvitamin d449.5SPP1, CALCA
13phosphorus449.5SPP1, CALCA
14creatinine449.5SPP1, BMP2
15fluoride449.5CALCA, SPP1
16hydroxyapatite449.4BMP2, SPP1
17neomycin449.4SPP1, BMP2
18polyethylene glycol449.4BMP2, SPP1
19infliximab44 49 1111.4TLR4, SPP1
20simvastatin44 49 59 28 11 2414.3BMP2, TLR4
21nifedipine44 49 28 1112.3BMP2, SPP1
22latex449.3SPP1, TLR4
23nitric oxide44 11 2411.0CALCA, BMP2, TLR4
241,25 dihydroxy vitamin d3449.0BMP2, CALCA, SPP1
25indomethacin44 59 28 1112.0SPP1, BMP2, CALCA
26testosterone44 59 11 2411.9SPP1, BMP2, CALCA
27tgf beta1448.9BMP2, TLR4, SPP1
28tacrolimus44 49 1110.9TLR4, BMP2, SPP1
29sb 20358044 599.9BMP2, TLR4, SPP1
30wortmannin448.9SPP1, BMP2, TLR4
31actinomycin d448.9SPP1, BMP2, TLR4
32genistein44 28 59 2 11 2413.9TLR4, SPP1, BMP2
33cholesterol44 28 11 2411.8TLR4, BMP2, SPP1
34dexamethasone44 49 28 1111.8TLR4, BMP2, SPP1
35estrogen448.7CALCA, BMP2, SPP1
36alanine448.7SPP1, BMP2, TLR4
37retinoic acid44 249.5SPP1, BMP2, TLR4
38calcitriol44 59 11 2411.4SPP1, BMP2, TLR4, CALCA
39vitamin d448.4TLR4, BMP2, SPP1, CALCA
40cyclosporin a44 28 5910.4SPP1, BMP2, TLR4, CALCA
41lactate448.4SPP1, CALCA, TLR4, BMP2
42cysteine448.4TLR4, SPP1, BMP2
43vegf448.4SPP1, BMP2, TLR4, CALCA
44calcium44 49 11 2411.3SPP1, CALCA, TLR4, BMP2
45glucose448.2SPP1, BMP2, TLR4

GO Terms for genes affiliated with Tympanosclerosis

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16Gene Ontology
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Cellular components related to Tympanosclerosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.6SPP1, BMP2, CALCA

Biological processes related to Tympanosclerosis according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of ossificationGO:0457789.6BMP2, CALCA
2negative regulation of osteoclast differentiationGO:0456719.5TLR4, CALCA
3positive regulation of interleukin-8 productionGO:0327579.4TLR4, CALCA
4positive regulation of ERK1 and ERK2 cascadeGO:0703749.3BMP2, TLR4
5embryo implantationGO:0075669.1SPP1, CALCA
6activation of MAPK activityGO:0001879.0BMP2, TLR4
7osteoblast differentiationGO:0016499.0SPP1, BMP2
8inflammatory responseGO:0069548.7CALCA, BMP2, SPP1

Products for genes affiliated with Tympanosclerosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Tympanosclerosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet