MCID: TYM001
MIFTS: 38

Tympanosclerosis malady

Ear diseases category

Summaries for Tympanosclerosis

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Wikipedia:63 Tympanosclerosis (also known as myringosclerosis or intratympanic tympanosclerosis) is a condition... more...

MalaCards based summary: Tympanosclerosis is related to pneumonia and atherosclerosis. An important gene associated with Tympanosclerosis is BMP2 (bone morphogenetic protein 2), and among its related pathways are Adipogenesis and TGF-beta Signaling Pathway. The compounds fibroin and methylmethacrylate have been mentioned in the context of this disorder. Affiliated tissues include bone, and related mouse phenotypes are hearing/vestibular/ear and limbs/digits/tail.

Aliases & Classifications for Tympanosclerosis

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Tympanosclerosis, Aliases & Descriptions:

Name: Tympanosclerosis 9 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Ear diseases


External Ids:

Disease Ontology9 DOID:1214
ICD9CM27 385.09
SNOMED-CT55 111540000
ICD1025 H74.0

Related Diseases for Tympanosclerosis

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Diseases related to Tympanosclerosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 46)
idRelated DiseaseScoreTop Affiliating Genes
1pneumonia29.8TNF, TLR4
2atherosclerosis29.8BMP2, TNF, TLR4, SPP1
3otitis media10.5
4trigeminal neuralgia10.4BMP2
5complex regional pain syndrome10.4CALCA
6blau syndrome10.4TNF
7coronary restenosis10.3SPP1
8synovitis10.3TNF
9calcinosis10.3SPP1
10cholesteatoma10.3
11pyelonephritis10.3TLR4
12arthropathy10.2BMP2, TNF
13aortic valve disease 210.1SPP1, BMP2
14hyperphosphatemia10.1BMP2, SPP1
15bone cancer10.1BMP2, SPP1
16thyroid carcinoma, papillary10.1SPP1, CALCA
17spondylarthropathy10.0TLR4, TNF
18chorioamnionitis10.0TNF, TLR4
19hypercalcemia10.0
20carotid stenosis10.0
21eustachian tube disease10.0
22middle ear disease10.0
23suppurative otitis media10.0
24deafness, progressive with stapes fixation10.0
25spondyloarthropathy 110.0TLR4, TNF
26periodontitis10.0TNF, TLR4
27monocytic leukemia10.0TNF, TLR4
28hypersensitivity reaction type ii disease10.0TNF, TLR4
29kidney disease10.0SPP1, TNF
30secondary syphilis9.9SPP1, BMP2, CALCA
31diabetes mellitus, insulin-dependent9.9TNF, BMP2, CALCA
32liver disease9.9TNF, TLR4
33osteoporosis9.9SPP1, BMP2, CALCA
34hepatitis c9.9TLR4, TNF
35colitis9.9TNF, TLR4
36atopic dermatitis9.8TLR4, TNF
37periodontal disease9.8TNF, TLR4, SPP1
38congenital heart disease9.8SPP1, TLR4, TNF
39systemic lupus erythematosus9.7TNF, TLR4, SPP1
40gastric cancer, somatic9.7SPP1, TLR4, BMP2
41osteoarthritis9.7SPP1, TNF, BMP2, CALCA
42lung cancer9.7SPP1, TLR4, BMP2
43arthritis9.6TLR4, TNF, BMP2, CALCA
44rheumatoid arthritis9.6BMP2, TNF, TLR4, SPP1
45melanoma9.6BMP2, TNF, TLR4, SPP1
46leukemia9.5TLR4, TNF, BMP2

Graphical network of the top 20 diseases related to Tympanosclerosis:



Diseases related to tympanosclerosis

Symptoms for Tympanosclerosis

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Drugs & Therapeutics for Tympanosclerosis

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Drug clinical trials:

Search ClinicalTrials for Tympanosclerosis

Search NIH Clinical Center for Tympanosclerosis

Genetic Tests for Tympanosclerosis

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Anatomical Context for Tympanosclerosis

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MalaCards organs/tissues related to Tympanosclerosis:

31
Bone

Animal Models for Tympanosclerosis or affiliated genes

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Publications for Tympanosclerosis

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Articles related to Tympanosclerosis:

(show top 50)    (show all 134)
idTitleAuthorsYear
1
The effect of stapes fixation on hearing results in tympanosclerosis treated by mobilization. (25472817)
2014
2
Morphological Alterations in the Tympanic Membrane Affected by Tympanosclerosis: Ultrastructural Study. (24134073)
2013
3
Expressions of TGF-I^1 and MMP-9 in a guinea pig model of tympanosclerosis: possible role in the pathogenesis of this disorder. (22777961)
2012
4
Could Helicobacter pylori play a role in the aetiopathogenesis of tympanosclerosis? (21888743)
2011
5
Serum matrix metalloproteinases and tympanosclerosis. (20955636)
2011
6
Does exogenous nitric oxide influence tympanosclerosis? An experimental study. (18945497)
2008
7
The effect of topical doxycycline in the prevention of experimental tympanosclerosis. (18388770)
2008
8
Management of tympanosclerosis with ossicular fixation: review and presentation of long-term results of 30 new cases. (17963670)
2007
9
Malleostapedotomy in tympanosclerosis patients. (17524174)
2007
10
Influence of hypercalcemia in the formation of tympanosclerosis in rats. (16371843)
2006
11
Tympanosclerosis involving the ossicular chain: mobility of the stapes in association with hearing results. (16923708)
2006
12
Possible relationship between tympanosclerosis and atherosclerosis. (15267174)
2004
13
Asymptomatic tympanosclerosis. (11816394)
2002
14
Tympanosclerosis: long-term hearing results after ossicular reconstruction. (11956534)
2002
15
Experimental hematotympanum--aspects to the tympanosclerosis development. (12137309)
2002
16
Sex distribution in children with tympanosclerosis after insertion of a tympanostomy tube. (11271428)
2001
17
Minimal tympanosclerosis (cosmetic). (11816885)
2001
18
Long-term ventilating tube with tympanosclerosis. (11011482)
2000
19
Extensive tympanosclerosis with a fixed malleus. (10355190)
1999
20
Tympanosclerosis with squamous epithelium in the tympanum. (10388186)
1999
21
Surgery of tympanosclerosis. (9425477)
1997
22
Tympanosclerosis-how we look at it. (23119284)
1997
23
Attic cholesteatoma and tympanosclerosis. (9210800)
1997
24
Surgical treatment of tympanosclerosis. (7718221)
1995
25
Tympanosclerosis and mini grommets: the relevance of grommet design. (7499941)
1995
26
Tympanic membrane perforation and tympanosclerosis with ossicular fixation. (8076533)
1994
27
Dry central tympanic membrane perforation and tympanosclerosis. (8313857)
1993
28
Tympanosclerosis. (8877197)
1993
29
Aspirating middle ear effusions when inserting ventilation tubes: does it influence post-operative otorrhoea, tube obstruction or the development of tympanosclerosis? (1742892)
1991
30
The significance of calcium antagonists in rat experimental tympanosclerosis. (3551898)
1987
31
Type II collagen mediated autoimmune middle ear disease: eustachian tube disease, otitis media with effusion and tympanosclerosis. (3835948)
1985
32
Prospective study of tympanosclerosis developing after grommet insertion. (6470572)
1984
33
Tympanosclerosis: clinical implications of the theory of pathogenesis. (6660756)
1983
34
Clinicopathologic studies in tympanosclerosis. (7055238)
1982
35
The ultrastructure of tympanosclerosis. The source of the matrix vesicles and the pattern of calcospherules. (7304723)
1981
36
Tympanosclerosis. A theory of pathogenesis. (6775569)
1980
37
Surgical treatment of tympanosclerosis. (703456)
1978
38
President's address. Tympanosclerosis. (1265007)
1976
39
Tympanosclerosis. (4687166)
1973
40
Histology of tympanosclerosis. (4110701)
1972
41
Tympanosclerosis. (4636824)
1972
42
Tympanosclerosis. (4996152)
1971
43
The pathology of tympanosclerosis. (5416456)
1970
44
Relation of otitis media chronica secretorica to tympanosclerosis. (5261124)
1969
45
Tympanosclerosis. (5782678)
1969
46
Tympanosclerosis. Electron microscopic study. (4908183)
1969
47
Tympanosclerosis. (5882309)
1965
48
TYMPANOSCLEROSIS. (14059349)
1963
49
Tympanosclerosis. (13964950)
1963
50
Tympanosclerosis--a revived clinocopathologic entity. (13904842)
1961

Variations for Tympanosclerosis

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Expression for genes affiliated with Tympanosclerosis

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Search GEO for disease gene expression data for Tympanosclerosis.

Pathways for genes affiliated with Tympanosclerosis

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Pathways related to Tympanosclerosis according to GeneCards Suite gene sharing:

(show all 28)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5BMP2, TNF
2
Show member pathways
9.5BMP2, TNF
39.4BMP2, SPP1
49.3TNF, SPP1
5
Show member pathways
Transcription NF kB signaling pathway58
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response58
9.1TNF, TLR4
69.1TNF, TLR4
79.1TNF, TLR4
8
Show member pathways
Immune response MIF in innate immunity response58
9.1TNF, TLR4
9
Show member pathways
9.1TLR4, TNF
109.1TNF, TLR4
119.1TNF, TLR4
129.1TLR4, TNF
139.1TNF, TLR4
149.1TNF, TLR4
159.1TLR4, TNF
16
Show member pathways
9.1TNF, TLR4
179.1TNF, TLR4
189.1TLR4, TNF
19
Show member pathways
9.1TNF, TLR4
209.1TNF, TLR4
21
Show member pathways
IL27-mediated signaling events36
9.1TNF, TLR4
22
Show member pathways
8.9BMP2, TNF, SPP1
238.8CALCA, TNF, SPP1
24
Show member pathways
8.7TLR4, TNF, BMP2
25
Show member pathways
8.7TLR4, TNF, BMP2
26
Show member pathways
8.7BMP2, TNF, TLR4
27
Show member pathways
8.5TNF, TLR4, SPP1
28
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
8.5SPP1, TLR4, TNF

Compounds for genes affiliated with Tympanosclerosis

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Compounds related to Tympanosclerosis according to GeneCards Suite gene sharing:

(show top 50)    (show all 83)
idCompoundScoreTop Affiliating Genes
1fibroin439.8SPP1, BMP2
2methylmethacrylate439.8SPP1, BMP2
3zoledronic acid439.8BMP2, CALCA
4alizarin439.8BMP2, SPP1
5alendronate43 49 1211.8BMP2, CALCA
6chitosan439.8SPP1, BMP2
7titanium439.7BMP2, SPP1
8alginate439.7SPP1, BMP2
925-hydroxyvitamin d439.5SPP1, CALCA
10d-galactosamine439.5TNF, TLR4
11zymosan439.5TLR4, TNF
12imiquimod43 59 28 1212.5TLR4, TNF
13phosphorus439.4SPP1, CALCA
14polymyxin b439.4TLR4, TNF
15lipoteichoic acid439.4TLR4, TNF
16fluoride439.4SPP1, CALCA
17polyinosinic-polycytidylic acid439.4TNF, TLR4
182,5-oligoadenylate439.3TLR4, TNF
191,25 dihydroxy vitamin d3439.3CALCA, SPP1, BMP2
20pd 98,059439.2BMP2, TNF, SPP1
21il 10439.1TNF, TLR4
22atorvastatin43 49 28 24 1213.1TLR4, BMP2, TNF
23simvastatin43 49 59 28 24 1214.1TLR4, BMP2, TNF
24poly(i-c)439.0TLR4, TNF
25mycophenolate mofetil43 49 1211.0SPP1, TNF
26histamine43 28 2411.0CALCA, TNF, TLR4
27infliximab43 49 1210.9TNF, TLR4, SPP1
28wortmannin438.9TLR4, BMP2, SPP1
29creatinine438.9BMP2, CALCA, SPP1
30fibrinogen438.9TNF, SPP1, TLR4
31ly294002438.8TLR4, TNF, SPP1
32indomethacin43 28 59 1211.8TNF, SPP1, BMP2, CALCA
33superoxide43 249.7TNF, SPP1, TLR4
34nitric oxide43 24 1210.5CALCA, TLR4, BMP2, TNF
35tgf beta1438.5BMP2, TNF, TLR4, SPP1
36tacrolimus43 49 1210.5TLR4, TNF, BMP2, SPP1
37sb 20358043 599.5BMP2, TNF, TLR4, SPP1
38vitamin d438.5BMP2, TLR4, SPP1, CALCA
39actinomycin d438.5BMP2, TLR4, SPP1, TNF
40genistein43 28 59 2 24 1213.5BMP2, SPP1, TLR4, TNF
41cycloheximide438.5BMP2, SPP1, TNF, TLR4
42dexamethasone43 49 28 1211.5TNF, TLR4, SPP1, BMP2
43retinoic acid43 249.4BMP2, SPP1, TLR4, TNF
44lipid438.4BMP2, TLR4, SPP1, TNF
45serine438.3TLR4, BMP2, SPP1, TNF
46calcitriol43 59 24 1211.0TNF, TLR4, CALCA, SPP1, BMP2
47cyclosporin a43 28 5910.0TLR4, CALCA, BMP2, SPP1, TNF
48pge2438.0TNF, CALCA, SPP1, TLR4, BMP2
49lactate438.0BMP2, TNF, SPP1, CALCA, TLR4
50vegf438.0BMP2, TNF, TLR4, SPP1, CALCA

GO Terms for genes affiliated with Tympanosclerosis

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Cellular components related to Tympanosclerosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055769.4BMP2, SPP1
2extracellular spaceGO:00056158.1CALCA, BMP2, TNF, SPP1

Biological processes related to Tympanosclerosis according to GeneCards Suite gene sharing:

(show all 26)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of ossificationGO:00457789.8CALCA, BMP2
2cellular response to organic cyclic compoundGO:00714079.8BMP2, TNF
3organ morphogenesisGO:00098879.6BMP2, TNF
4embryo implantationGO:00075669.6CALCA, SPP1
5osteoblast differentiationGO:00016499.5SPP1, BMP2
6positive regulation of protein phosphorylationGO:00019349.5TNF, BMP2
7response to hypoxiaGO:00016669.5BMP2, TNF
8positive regulation of interleukin-8 biosynthetic processGO:00454169.5TNF, TLR4
9positive regulation of chemokine productionGO:00327229.5TLR4, TNF
10positive regulation of NF-kappaB import into nucleusGO:00423469.5TNF, TLR4
11negative regulation of osteoclast differentiationGO:00456719.5CALCA, TLR4
12positive regulation of interleukin-8 productionGO:00327579.5CALCA, TLR4
13negative regulation of interleukin-6 productionGO:00327159.4TLR4, TNF
14lipopolysaccharide-mediated signaling pathwayGO:00316639.4TNF, TLR4
15positive regulation of nitric oxide biosynthetic processGO:00454299.4TLR4, TNF
16positive regulation of interferon-gamma productionGO:00327299.4TNF, TLR4
17positive regulation of interleukin-6 productionGO:00327559.4TLR4, TNF
18positive regulation of JNK cascadeGO:00463309.3TNF, TLR4
19negative regulation of transcription, DNA-templatedGO:00458929.2CALCA, BMP2, TNF
20extracellular matrix organizationGO:00301989.2BMP2, TNF, SPP1
21activation of MAPK activityGO:00001879.0BMP2, TNF, TLR4
22positive regulation of ERK1 and ERK2 cascadeGO:00703749.0TLR4, TNF, BMP2
23positive regulation of NF-kappaB transcription factor activityGO:00510929.0TNF, TLR4
24positive regulation of I-kappaB kinase/NF-kappaB signalingGO:00431238.8TNF, TLR4
25positive regulation of transcription from RNA polymerase II promoterGO:00459448.7BMP2, TNF, TLR4
26inflammatory responseGO:00069548.7CALCA, BMP2, TNF, SPP1

Molecular functions related to Tympanosclerosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051258.9BMP2, TNF, SPP1

Products for genes affiliated with Tympanosclerosis

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Sources for Tympanosclerosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet