MCID: TYM001
MIFTS: 45

Tympanosclerosis malady

Ear diseases category

Summaries for Tympanosclerosis

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66Wikipedia, 34MalaCards
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Wikipedia:66 Tympanosclerosis (also known as myringosclerosis or intratympanic tympanosclerosis) is a condition... more...

MalaCards: Tympanosclerosis is related to atherosclerosis and otitis media. An important gene associated with Tympanosclerosis is BMP2 (bone morphogenetic protein 2), and among its related pathways are Adipogenesis and TGF-beta Signaling Pathway. The compounds fibroin and methylmethacrylate have been mentioned in the context of this disorder. Affiliated tissues include bone, and related mouse phenotypes are hearing/vestibular/ear and limbs/digits/tail.

Aliases & Classifications for Tympanosclerosis

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Sources:
9Disease Ontology, 63UMLS, 59SNOMED-CT, 28ICD9CM, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Ear diseases


Aliases & Descriptions:

tympanosclerosis 9 63


External Ids:

Disease Ontology9 DOID:1214
ICD9CM28 385.09
SNOMED-CT59 111540000
ICD1026 H74.0

Related Diseases for Tympanosclerosis

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Tympanosclerosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 47)
idRelated DiseaseScoreTop Affiliating Genes
1atherosclerosis30.1TNF, SPP1, TLR4, BMP2
2otitis media10.4
3cholesteatoma10.3
4trigeminal neuralgia10.1BMP2
5complex regional pain syndrome10.1CALCA
6blau syndrome10.1TNF
7coronary restenosis10.1SPP1
8synovitis10.1TNF
9calcinosis10.1SPP1
10pyelonephritis10.1TLR4
11arthropathy10.0BMP2, TNF
12aortic valve stenosis10.0BMP2, SPP1
13hyperphosphatemia10.0SPP1, BMP2
14bone carcinoma10.0BMP2, SPP1
15papillary thyroid carcinoma10.0SPP1, CALCA
16hypercalcemia10.0
17carotid stenosis10.0
18eustachian tube disease10.0
19middle ear disease10.0
20suppurative otitis media10.0
21deafness, progressive with stapes fixation10.0
22spondylarthropathy10.0TLR4, TNF
23chorioamnionitis10.0TLR4, TNF
24ankylosing spondylitis10.0TLR4, TNF
25periodontitis10.0TLR4, TNF
26monocytic leukemia10.0TLR4, TNF
27primary hyperoxaluria10.0SPP1, TNF
28septic shock10.0TNF, TLR4
29hypersensitivity reaction type ii disease10.0TLR4, TNF
30secondary syphilis10.0CALCA, BMP2, SPP1
31diabetes mellitus10.0BMP2, TNF, CALCA
32osteoporosis10.0SPP1, CALCA, BMP2
33galactosemia10.0TNF, TLR4
34hepatitis c10.0TNF, TLR4
35pneumonia10.0TLR4, TNF
36atopic dermatitis10.0TNF, TLR4
37sepsis10.0CALCA, TLR4, TNF
38periodontal disease9.9TNF, TLR4, SPP1
39congenital heart disease9.9SPP1, TLR4, TNF
40systemic lupus erythematosus9.9SPP1, TLR4, TNF
41stomach cancer9.9BMP2, TLR4, SPP1
42osteoarthritis9.9CALCA, SPP1, TNF, BMP2
43lung cancer9.9BMP2, SPP1, TLR4
44arthritis9.9TLR4, BMP2, CALCA, TNF
45rheumatoid arthritis9.9TNF, TLR4, BMP2, SPP1
46melanoma9.9TNF, TLR4, SPP1, BMP2
47leukemia9.9TLR4, BMP2, TNF

Graphical network of the top 20 diseases related to Tympanosclerosis:



Diseases related to tympanosclerosis

Symptoms for Tympanosclerosis

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Drugs & Therapeutics for Tympanosclerosis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Tympanosclerosis

Drug clinical trials:

Search ClinicalTrials for Tympanosclerosis

Search NIH Clinical Center for Tympanosclerosis

Search CenterWatch for Tympanosclerosis

Genetic Tests for Tympanosclerosis

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Anatomical Context for Tympanosclerosis

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Sources:
34MalaCards
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MalaCards organs/tissues related to Tympanosclerosis:

34
Bone

Animal Models for Tympanosclerosis or affiliated genes

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Sources:
38MGI
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Publications for Tympanosclerosis

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Sources:
53PubMed
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Articles related to Tympanosclerosis:

(show top 50)    (show all 126)
idTitleAuthorsYear
1
Morphological Alterations in the Tympanic Membrane Affected by Tympanosclerosis: Ultrastructural Study. (24134073)
2013
2
Expressions of TGF-I^1 and MMP-9 in a guinea pig model of tympanosclerosis: possible role in the pathogenesis of this disorder. (22777961)
2012
3
Could Helicobacter pylori play a role in the aetiopathogenesis of tympanosclerosis? (21888743)
2011
4
Serum matrix metalloproteinases and tympanosclerosis. (20955636)
2011
5
Does exogenous nitric oxide influence tympanosclerosis? An experimental study. (18945497)
2008
6
The effect of topical doxycycline in the prevention of experimental tympanosclerosis. (18388770)
2008
7
Management of tympanosclerosis with ossicular fixation: review and presentation of long-term results of 30 new cases. (17963670)
2007
8
Malleostapedotomy in tympanosclerosis patients. (17524174)
2007
9
Influence of hypercalcemia in the formation of tympanosclerosis in rats. (16371843)
2006
10
Tympanosclerosis involving the ossicular chain: mobility of the stapes in association with hearing results. (16923708)
2006
11
Possible relationship between tympanosclerosis and atherosclerosis. (15267174)
2004
12
Asymptomatic tympanosclerosis. (11816394)
2002
13
Tympanosclerosis: long-term hearing results after ossicular reconstruction. (11956534)
2002
14
Experimental hematotympanum--aspects to the tympanosclerosis development. (12137309)
2002
15
Sex distribution in children with tympanosclerosis after insertion of a tympanostomy tube. (11271428)
2001
16
Minimal tympanosclerosis (cosmetic). (11816885)
2001
17
Long-term ventilating tube with tympanosclerosis. (11011482)
2000
18
Extensive tympanosclerosis with a fixed malleus. (10355190)
1999
19
Tympanosclerosis with squamous epithelium in the tympanum. (10388186)
1999
20
Surgery of tympanosclerosis. (9425477)
1997
21
Tympanosclerosis-how we look at it. (23119284)
1997
22
Attic cholesteatoma and tympanosclerosis. (9210800)
1997
23
Surgical treatment of tympanosclerosis. (7718221)
1995
24
Tympanosclerosis and mini grommets: the relevance of grommet design. (7499941)
1995
25
Tympanic membrane perforation and tympanosclerosis with ossicular fixation. (8076533)
1994
26
Dry central tympanic membrane perforation and tympanosclerosis. (8313857)
1993
27
Tympanosclerosis. (8877197)
1993
28
Development of tympanosclerosis in children with otitis media with effusion and ventilation tubes. (1919311)
1991
29
Aspirating middle ear effusions when inserting ventilation tubes: does it influence post-operative otorrhoea, tube obstruction or the development of tympanosclerosis? (1742892)
1991
30
Type II collagen mediated autoimmune middle ear disease: eustachian tube disease, otitis media with effusion and tympanosclerosis. (3835948)
1985
31
Prospective study of tympanosclerosis developing after grommet insertion. (6470572)
1984
32
Tympanosclerosis of the ear drum in secretory otitis media. (6598264)
1984
33
Tympanosclerosis: clinical implications of the theory of pathogenesis. (6660756)
1983
34
Clinicopathologic studies in tympanosclerosis. (7055238)
1982
35
The ultrastructure of tympanosclerosis. The source of the matrix vesicles and the pattern of calcospherules. (7304723)
1981
36
Tympanosclerosis. A theory of pathogenesis. (6775569)
1980
37
Surgical treatment of tympanosclerosis. (703456)
1978
38
President's address. Tympanosclerosis. (1265007)
1976
39
Tympanosclerosis. (4687166)
1973
40
Histology of tympanosclerosis. (4110701)
1972
41
Tympanosclerosis. (4636824)
1972
42
Tympanosclerosis. (4996152)
1971
43
The pathology of tympanosclerosis. (5416456)
1970
44
Relation of otitis media chronica secretorica to tympanosclerosis. (5261124)
1969
45
Tympanosclerosis. (5782678)
1969
46
Tympanosclerosis. Electron microscopic study. (4908183)
1969
47
Tympanosclerosis. (5882309)
1965
48
TYMPANOSCLEROSIS. (14059349)
1963
49
Tympanosclerosis. (13964950)
1963
50
Tympanosclerosis--a revived clinocopathologic entity. (13904842)
1961

Variations for Tympanosclerosis

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Expression for genes affiliated with Tympanosclerosis

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Tympanosclerosis

Search GEO for disease gene expression data for Tympanosclerosis.

Pathways for genes affiliated with Tympanosclerosis

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Sources:
51PathCards, 39NCBI BioSystems Database, 58SinoBiological, 31KEGG, 61Thomson Reuters, 54QIAGEN, 56Reactome, 5Cell Signaling Technology, 55R&D Systems
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Pathways related to Tympanosclerosis according to GeneCards/GeneDecks:

(show all 28)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5BMP2, TNF
2
Show member pathways
9.5BMP2, TNF
39.4BMP2, SPP1
49.3TNF, SPP1
5
Show member pathways
Transcription NF kB signaling pathway61
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response61
9.1TNF, TLR4
69.1TNF, TLR4
79.1TNF, TLR4
8
Show member pathways
Immune response MIF in innate immunity response61
9.1TNF, TLR4
9
Show member pathways
9.1TLR4, TNF
109.1TNF, TLR4
119.1TNF, TLR4
129.1TLR4, TNF
139.1TNF, TLR4
149.1TNF, TLR4
159.1TLR4, TNF
16
Show member pathways
9.1TNF, TLR4
179.1TNF, TLR4
189.1TLR4, TNF
19
Show member pathways
9.1TNF, TLR4
209.1TNF, TLR4
21
Show member pathways
IL27-mediated signaling events39
9.1TNF, TLR4
22
Show member pathways
8.9BMP2, TNF, SPP1
238.8CALCA, TNF, SPP1
24
Show member pathways
8.7TLR4, TNF, BMP2
25
Show member pathways
8.7TLR4, TNF, BMP2
26
Show member pathways
8.7BMP2, TNF, TLR4
27
Show member pathways
8.5TNF, TLR4, SPP1
28
Show member pathways
Toll-like receptor signaling pathway39
Regulation of toll-like receptor signaling pathway39
8.5SPP1, TLR4, TNF

Compounds for genes affiliated with Tympanosclerosis

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Sources:
46Novoseek, 52PharmGKB, 12DrugBank, 62Tocris Bioscience, 30IUPHAR, 25HMDB, 3BitterDB
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Compounds related to Tympanosclerosis according to GeneCards/GeneDecks:

(show top 50)    (show all 83)
idCompoundScoreTop Affiliating Genes
1fibroin469.8SPP1, BMP2
2methylmethacrylate469.8SPP1, BMP2
3zoledronic acid469.8BMP2, CALCA
4alizarin469.8BMP2, SPP1
5alendronate46 52 1211.8BMP2, CALCA
6chitosan469.8SPP1, BMP2
7titanium469.7BMP2, SPP1
8alginate469.7SPP1, BMP2
925-hydroxyvitamin d469.5SPP1, CALCA
10d-galactosamine469.5TNF, TLR4
11zymosan469.5TLR4, TNF
12imiquimod46 62 30 1212.5TLR4, TNF
13phosphorus469.4SPP1, CALCA
14polymyxin b469.4TLR4, TNF
15lipoteichoic acid469.4TLR4, TNF
16fluoride469.4SPP1, CALCA
17polyinosinic-polycytidylic acid469.4TNF, TLR4
182,5-oligoadenylate469.3TLR4, TNF
191,25 dihydroxy vitamin d3469.3CALCA, SPP1, BMP2
20pd 98,059469.2BMP2, TNF, SPP1
21il 10469.1TNF, TLR4
22atorvastatin46 52 30 25 1213.1TLR4, BMP2, TNF
23simvastatin46 52 62 30 25 1214.1TLR4, BMP2, TNF
24poly(i-c)469.0TLR4, TNF
25mycophenolate mofetil46 52 1211.0SPP1, TNF
26histamine46 30 2511.0CALCA, TNF, TLR4
27infliximab46 52 1210.9TNF, TLR4, SPP1
28wortmannin468.9TLR4, BMP2, SPP1
29creatinine468.9BMP2, CALCA, SPP1
30fibrinogen468.9TNF, SPP1, TLR4
31ly294002468.8TLR4, TNF, SPP1
32indomethacin46 30 62 1211.8TNF, SPP1, BMP2, CALCA
33superoxide46 259.7TNF, SPP1, TLR4
34nitric oxide46 25 1210.5CALCA, TLR4, BMP2, TNF
35tgf beta1468.5BMP2, TNF, TLR4, SPP1
36tacrolimus46 52 1210.5TLR4, TNF, BMP2, SPP1
37sb 20358046 629.5BMP2, TNF, TLR4, SPP1
38vitamin d468.5BMP2, TLR4, SPP1, CALCA
39actinomycin d468.5BMP2, TLR4, SPP1, TNF
40genistein46 30 62 3 25 1213.5BMP2, SPP1, TLR4, TNF
41cycloheximide468.5BMP2, SPP1, TNF, TLR4
42dexamethasone46 52 30 1211.5TNF, TLR4, SPP1, BMP2
43retinoic acid46 259.4BMP2, SPP1, TLR4, TNF
44lipid468.4BMP2, TLR4, SPP1, TNF
45serine468.3TLR4, BMP2, SPP1, TNF
46calcitriol46 62 25 1211.0TNF, TLR4, CALCA, SPP1, BMP2
47cyclosporin a46 30 6210.0TLR4, CALCA, BMP2, SPP1, TNF
48pge2468.0TNF, CALCA, SPP1, TLR4, BMP2
49lactate468.0BMP2, TNF, SPP1, CALCA, TLR4
50vegf468.0BMP2, TNF, TLR4, SPP1, CALCA

GO Terms for genes affiliated with Tympanosclerosis

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17Gene Ontology
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Cellular components related to Tympanosclerosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055769.4BMP2, SPP1
2extracellular spaceGO:0056158.1CALCA, BMP2, TNF, SPP1

Biological processes related to Tympanosclerosis according to GeneCards/GeneDecks:

(show all 26)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of ossificationGO:0457789.8CALCA, BMP2
2cellular response to organic cyclic compoundGO:0714079.8BMP2, TNF
3organ morphogenesisGO:0098879.6BMP2, TNF
4embryo implantationGO:0075669.6CALCA, SPP1
5osteoblast differentiationGO:0016499.5SPP1, BMP2
6positive regulation of protein phosphorylationGO:0019349.5TNF, BMP2
7response to hypoxiaGO:0016669.5BMP2, TNF
8positive regulation of interleukin-8 biosynthetic processGO:0454169.5TNF, TLR4
9positive regulation of chemokine productionGO:0327229.5TLR4, TNF
10positive regulation of NF-kappaB import into nucleusGO:0423469.5TNF, TLR4
11negative regulation of osteoclast differentiationGO:0456719.5CALCA, TLR4
12positive regulation of interleukin-8 productionGO:0327579.5CALCA, TLR4
13negative regulation of interleukin-6 productionGO:0327159.4TLR4, TNF
14lipopolysaccharide-mediated signaling pathwayGO:0316639.4TNF, TLR4
15positive regulation of nitric oxide biosynthetic processGO:0454299.4TLR4, TNF
16positive regulation of interferon-gamma productionGO:0327299.4TNF, TLR4
17positive regulation of interleukin-6 productionGO:0327559.4TLR4, TNF
18positive regulation of JNK cascadeGO:0463309.3TNF, TLR4
19negative regulation of transcription, DNA-templatedGO:0458929.2CALCA, BMP2, TNF
20extracellular matrix organizationGO:0301989.2BMP2, TNF, SPP1
21activation of MAPK activityGO:0001879.0BMP2, TNF, TLR4
22positive regulation of ERK1 and ERK2 cascadeGO:0703749.0TLR4, TNF, BMP2
23positive regulation of NF-kappaB transcription factor activityGO:0510929.0TNF, TLR4
24positive regulation of I-kappaB kinase/NF-kappaB signalingGO:0431238.8TNF, TLR4
25positive regulation of transcription from RNA polymerase II promoterGO:0459448.7BMP2, TNF, TLR4
26inflammatory responseGO:0069548.7CALCA, BMP2, TNF, SPP1

Molecular functions related to Tympanosclerosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051258.9BMP2, TNF, SPP1

Products for genes affiliated with Tympanosclerosis

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Sources for Tympanosclerosis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet