Aliases & Classifications for Tympanosclerosis

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Aliases & Descriptions for Tympanosclerosis:

Name: Tympanosclerosis 11 13 66

Classifications:



External Ids:

Disease Ontology11 DOID:1214
ICD9CM30 385.09
SNOMED-CT60 111540000
ICD1028 H74.0

Summaries for Tympanosclerosis

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Wikipedia:69 Tympanosclerosis (also known as myringosclerosis or intratympanic tympanosclerosis) is a condition... more...

MalaCards based summary: Tympanosclerosis is related to otitis media and antigen-peptide-transporter 2 deficiency, and has symptoms including tympanic membrane hyperaemia An important gene associated with Tympanosclerosis is TLR4 (Toll Like Receptor 4), and among its related pathways are Rheumatoid arthritis and Pertussis. Affiliated tissues include bone.

Related Diseases for Tympanosclerosis

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Diseases related to Tympanosclerosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 67)
idRelated DiseaseScoreTop Affiliating Genes
1otitis media10.3
2antigen-peptide-transporter 2 deficiency10.2TLR4, TNF
3paraneoplastic polyneuropathy10.2TLR4, TNF
4spondylohypoplasia, arthrogryposis and popliteal pterygium10.2TLR4, TNF
5gastroduodenal crohn's disease10.2TLR4, TNF
6inner ear cancer10.2TLR4, TNF
7accessory nerve disease10.2TLR4, TNF
8acute cholangitis10.2TLR4, TNF
9bartonellosis10.2TLR4, TNF
10binocular vision disease10.2TLR4, TNF
11benign lymphoepithelial lesion of salivary gland10.2TLR4, TNF
12nasopharyngitis10.2TLR4, TNF
13corneal intraepithelial neoplasm10.2TLR4, TNF
14retroperitoneal fibrosis10.2TLR4, TNF
15neonatal period electroclinical syndrome10.2TLR4, TNF
16esophagus melanoma10.2TLR4, TNF
17cutaneous porphyria10.2TLR4, TNF
18dengue disease10.2TLR4, TNF
19gastric ulcer10.2TLR4, TNF
20diphtheria10.2TLR4, TNF
21mononeuritis of lower limb10.2TLR4, TNF
22lymphangioma10.2TLR4, TNF
23variola minor10.1TLR4, TNF
24keratosis10.1TLR4, TNF
25hemorrhagic fever with renal syndrome10.1TLR4, TNF
26cholesteatoma10.1
27heart septal defect10.1TLR4, TNF
28uterine inversion10.1TLR4, TNF
29deafness, autosomal recessive 6210.1TLR4, TNF
30motion sickness10.1TLR4, TNF
31rectum leiomyosarcoma10.1TLR4, TNF
32cryoglobulinemia10.1TLR4, TNF
33pleomorphic lipoma10.1BMP2, TNF
34atypical follicular adenoma10.1TLR4, TNF
35laryngeal tuberculosis10.1TLR4, TNF
36sheehan syndrome10.1TLR4, TNF
37atherosclerosis10.1
38foveal hypoplasia 110.1TLR4, TNF
39congenital disorder of glycosylation, type ih10.1TLR4, TNF
40perianal skin paget's disease10.0TLR4, TNF
41palmoplantar keratosis10.0TLR4, TNF
42low compliance bladder10.0TLR4, TNF
43lethal midline granuloma10.0TLR4, TNF
44pneumonia10.0
45chronic rhinitis10.0TLR4, TNF
46deafness, progressive, with stapes fixation10.0
47basaloid squamous cell carcinoma10.0TLR4, TNF
48respiratory failure9.9TLR4, TNF
49physical disorder9.9BMP2, CALCA
50bone deterioration disease9.9BMP2, CALCA

Graphical network of the top 20 diseases related to Tympanosclerosis:



Diseases related to tympanosclerosis

Symptoms for Tympanosclerosis

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UMLS symptoms related to Tympanosclerosis:


tympanic membrane hyperaemia

Drugs & Therapeutics for Tympanosclerosis

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Interventional clinical trials:

idNameStatusNCT IDPhase
1Gas Supply, Demand and Middle Ear Gas Balance: Specific Aim 3cCompletedNCT00422851

Search NIH Clinical Center for Tympanosclerosis

Genetic Tests for Tympanosclerosis

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Anatomical Context for Tympanosclerosis

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MalaCards organs/tissues related to Tympanosclerosis:

34
Bone

Animal Models for Tympanosclerosis or affiliated genes

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Publications for Tympanosclerosis

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Articles related to Tympanosclerosis:

(show top 50)    (show all 143)
idTitleAuthorsYear
1
Tympanosclerosis Presenting as Mass: Workup and Differential. (27656306)
2016
2
The effect of melatonin and vitamin C treatment on the experimentally induced tympanosclerosis: study in rats. (27484331)
2016
3
An Analysis of Surgical Treatment Results of Patients With Tympanosclerosis. (26517462)
2015
4
Expressions of TGF-I^1 and MMP-9 in a guinea pig model of tympanosclerosis: possible role in the pathogenesis of this disorder. (22777961)
2012
5
Could Helicobacter pylori play a role in the aetiopathogenesis of tympanosclerosis? (21888743)
2011
6
Serum matrix metalloproteinases and tympanosclerosis. (20955636)
2011
7
Hearing results of surgery for tympanosclerosis. (18704475)
2009
8
Expression and localization of macrophages and BMP2 in mucosa of tympanosclerosis]. (19670606)
2009
9
The effect of topical doxycycline in the prevention of experimental tympanosclerosis. (18388770)
2008
10
The effect of stapes mobility on hearing outcome and which procedure to choose in fixed stapes in children tympanosclerosis. (18394718)
2008
11
Management of tympanosclerosis with ossicular fixation: review and presentation of long-term results of 30 new cases. (17963670)
2007
12
Malleostapedotomy in tympanosclerosis patients. (17524174)
2007
13
Tympanosclerosis involving the ossicular chain: mobility of the stapes in association with hearing results. (16923708)
2006
14
Possible relationship between tympanosclerosis and atherosclerosis. (15267174)
2004
15
Comparison of free radicals and antioxidant enzymes in chronic otitis media with and without tympanosclerosis. (14710000)
2004
16
Tympanosclerosis: long-term hearing results after ossicular reconstruction. (11956534)
2002
17
Experimental hematotympanum--aspects to the tympanosclerosis development. (12137309)
2002
18
Possible inflammatory mediators in tympanosclerosis development. (11955606)
2002
19
Sex distribution in children with tympanosclerosis after insertion of a tympanostomy tube. (11271428)
2001
20
Quantitation and prevalence of tympanosclerosis in a pediatric otolaryngology clinic. (11551611)
2001
21
Expression of osteopontin by exudate macrophages in inflammatory tissues of the middle ear: a possible association with development of tympanosclerosis. (11223300)
2001
22
Long-term ventilating tube with tympanosclerosis. (11011482)
2000
23
Tympanosclerosis. (10665186)
2000
24
Extensive tympanosclerosis with a fixed malleus. (10355190)
1999
25
Serous otitis media with tympanosclerosis and healed neomembrane. (9787511)
1998
26
Surgery of tympanosclerosis. (9425477)
1997
27
Attic cholesteatoma and tympanosclerosis. (9210800)
1997
28
Surgical treatment of tympanosclerosis. (7718221)
1995
29
Tympanosclerosis in the tympanic membrane: influence on outcome of myringoplasty. (8572148)
1995
30
Aspirating middle ear effusions when inserting ventilation tubes: does it influence post-operative otorrhoea, tube obstruction or the development of tympanosclerosis? (1742892)
1991
31
Tympanosclerosis of the middle ear: late results of surgical treatment. (2230573)
1990
32
Aspiration of middle ear effusions prior to grommet insertion an etiological factor in tympanosclerosis. (2769837)
1989
33
Hearing loss in tympanosclerosis caused by grommets. (2751852)
1989
34
Experimental tympanosclerosis following infection with Streptococcus pyogenes and vitamin D3 intoxication. (3028346)
1986
35
Type II collagen mediated autoimmune middle ear disease: eustachian tube disease, otitis media with effusion and tympanosclerosis. (3835948)
1985
36
Prospective study of tympanosclerosis developing after grommet insertion. (6470572)
1984
37
Tympanosclerosis of the ear drum in secretory otitis media. (6598264)
1984
38
Tympanosclerosis: clinical implications of the theory of pathogenesis. (6660756)
1983
39
Metaplasic bone tissue in tympanosclerosis. (6880665)
1983
40
The ultrastructure of tympanosclerosis. The source of the matrix vesicles and the pattern of calcospherules. (7304723)
1981
41
Tympanosclerosis of the ear drum. A scanning electronmicroscopic study. (7257755)
1981
42
Tympanosclerosis. A theory of pathogenesis. (6775569)
1980
43
Initiation and stages of mineralization in tympanosclerosis. (6255048)
1980
44
Surgical treatment of tympanosclerosis. (703456)
1978
45
Histology of tympanosclerosis. (4110701)
1972
46
Tympanosclerosis. (4636824)
1972
47
Tympanosclerosis. (4996152)
1971
48
Relation of otitis media chronica secretorica to tympanosclerosis. (5261124)
1969
49
TYMPANOSCLEROSIS. (14059349)
1963
50
Tympanosclerosis. (13911558)
1962

Variations for Tympanosclerosis

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Expression for genes affiliated with Tympanosclerosis

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Search GEO for disease gene expression data for Tympanosclerosis.

Pathways for genes affiliated with Tympanosclerosis

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GO Terms for genes affiliated with Tympanosclerosis

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Cellular components related to Tympanosclerosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:00099868.9BMP2, TLR4, TNF

Biological processes related to Tympanosclerosis according to GeneCards Suite gene sharing:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of chemokine productionGO:003272210.1TLR4, TNF
2positive regulation of interleukin-8 biosynthetic processGO:004541610.0TLR4, TNF
3positive regulation of NF-kappaB import into nucleusGO:004234610.0TLR4, TNF
4lipopolysaccharide-mediated signaling pathwayGO:003166310.0TLR4, TNF
5positive regulation of interferon-gamma productionGO:003272910.0TLR4, TNF
6I-kappaB kinase/NF-kappaB signalingGO:00072499.9TLR4, TNF
7negative regulation of interleukin-6 productionGO:00327159.9TLR4, TNF
8positive regulation of JNK cascadeGO:00463309.8TLR4, TNF
9positive regulation of interleukin-8 productionGO:00327579.7TLR4, TNF
10positive regulation of ossificationGO:00457789.7BMP2, CALCA
11positive regulation of interleukin-6 productionGO:00327559.7TLR4, TNF
12cellular response to organic cyclic compoundGO:00714079.7BMP2, TNF
13positive regulation of nitric oxide biosynthetic processGO:00454299.6TLR4, TNF
14apoptotic signaling pathwayGO:00971909.5TLR4, TNF
15positive regulation of gene expressionGO:00106288.9BMP2, TLR4, TNF
16activation of MAPK activityGO:00001878.9BMP2, TLR4, TNF
17positive regulation of ERK1 and ERK2 cascadeGO:00703748.6BMP2, TLR4, TNF
18negative regulation of transcription, DNA-templatedGO:00458928.4BMP2, CALCA, TNF
19inflammatory responseGO:00069548.4BMP2, CALCA, TLR4, TNF

Sources for Tympanosclerosis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet