Aliases & Classifications for Tympanosclerosis

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Aliases & Descriptions for Tympanosclerosis:

Name: Tympanosclerosis 10 12 65


Classifications:



External Ids:

Disease Ontology10 DOID:1214
ICD9CM29 385.09
SNOMED-CT59 111540000
ICD1027 H74.0

Summaries for Tympanosclerosis

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Wikipedia:68 Tympanosclerosis (also known as myringosclerosis or intratympanic tympanosclerosis) is a condition... more...

MalaCards based summary: Tympanosclerosis is related to otitis media and atherosclerosis. An important gene associated with Tympanosclerosis is BMP2 (Bone Morphogenetic Protein 2), and among its related pathways are and Rheumatoid arthritis. Affiliated tissues include bone, and related mouse phenotypes are hearing/vestibular/ear and skeleton.

Related Diseases for Tympanosclerosis

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Diseases related to Tympanosclerosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 51)
idRelated DiseaseScoreTop Affiliating Genes
1otitis media30.6TLR4, TNF
2atherosclerosis10.3
3cholesteatoma10.3
4pneumonia10.2
5dengue disease10.1BMP2, CALCA
6bone structure disease10.1BMP2, CALCA
7carotid stenosis10.1
8hypercalcemia10.1
9eustachian tube disease10.1
10middle ear disease10.1
11deafness, progressive with stapes fixation10.1
12intermediate dend syndrome10.0CALCA, TNF
13congenital heart disease10.0CALCA, TNF
14hemifacial spasm10.0CALCA, TNF
15focal myositis10.0CALCA, TNF
16otitis externa9.9BMP2, TNF
17spondylocamptodactyly9.9TLR4, TNF
18anti-hla hyperimmunization9.9TLR4, TNF
19migraine with aura9.9TLR4, TNF
20prostate stromal sarcoma9.9CALCA, TNF
21epiphora due to insufficient drainage9.9TLR4, TNF
22diversion colitis9.9TLR4, TNF
23acute allergic serous otitis media9.9TLR4, TNF
24sarcoidosis, early-onset9.9TLR4, TNF
25blastomycosis9.9TLR4, TNF
26chronic mucocutaneous candidiasis9.9TLR4, TNF
27idiopathic spinal cord herniation9.9TLR4, TNF
28leiomyoma9.9TLR4, TNF
29mesenteric vascular occlusion9.9TLR4, TNF
30bubonic plague9.9TLR4, TNF
31pyloric stenosis9.9TLR4, TNF
32focal chorioretinitis9.9TLR4, TNF
33balanitis xerotica obliterans9.9TLR4, TNF
34balanitis9.9TLR4, TNF
35mixed cerebral palsy9.9TLR4, TNF
36lymphangioma9.9TLR4, TNF
37xeroderma of eyelid9.9TLR4, TNF
38dacryoadenitis9.9TLR4, TNF
39transient arthritis9.9TLR4, TNF
40keratitis9.9TLR4, TNF
41hypoglycemic coma9.8TLR4, TNF
42mononeuritis9.8TLR4, TNF
43dysthymic disorder9.8TLR4, TNF
44pervasive developmental disorder9.8TLR4, TNF
45lens disease9.8TLR4, TNF
46occlusion precerebral artery9.8CALCA, TNF
47periodontitis9.8TLR4, TNF
48pneumothorax9.8TLR4, TNF
49osteoporosis9.8BMP2, CALCA, TNF
50periostitis9.6TLR4, TNF

Graphical network of the top 20 diseases related to Tympanosclerosis:



Diseases related to tympanosclerosis

Symptoms for Tympanosclerosis

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Drugs & Therapeutics for Tympanosclerosis

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Interventional clinical trials:

idNameStatusNCT IDPhase
1Gas Supply, Demand and Middle Ear Gas Balance: Specific Aim 3cCompletedNCT00422851

Search NIH Clinical Center for Tympanosclerosis

Genetic Tests for Tympanosclerosis

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Anatomical Context for Tympanosclerosis

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MalaCards organs/tissues related to Tympanosclerosis:

33
Bone

Animal Models for Tympanosclerosis or affiliated genes

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MGI Mouse Phenotypes related to Tympanosclerosis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053779.1BMP2, CALCA, TLR4
2MP:00053908.3BMP2, CALCA, TLR4, TNF
3MP:00053808.1BMP2, CALCA, MTFMT, TNF
4MP:00053767.5BMP2, CALCA, MTFMT, TLR4, TNF
5MP:00107687.4BMP2, CALCA, MTFMT, TLR4, TNF

Publications for Tympanosclerosis

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Articles related to Tympanosclerosis:

(show top 50)    (show all 138)
idTitleAuthorsYear
1
The effect of stapes fixation on hearing results in tympanosclerosis treated by mobilization. (25472817)
2014
2
Morphological Alterations in the Tympanic Membrane Affected by Tympanosclerosis: Ultrastructural Study. (24134073)
2013
3
Expressions of TGF-I^1 and MMP-9 in a guinea pig model of tympanosclerosis: possible role in the pathogenesis of this disorder. (22777961)
2012
4
Could Helicobacter pylori play a role in the aetiopathogenesis of tympanosclerosis? (21888743)
2011
5
Serum matrix metalloproteinases and tympanosclerosis. (20955636)
2011
6
Does exogenous nitric oxide influence tympanosclerosis? An experimental study. (18945497)
2008
7
The effect of topical doxycycline in the prevention of experimental tympanosclerosis. (18388770)
2008
8
Management of tympanosclerosis with ossicular fixation: review and presentation of long-term results of 30 new cases. (17963670)
2007
9
Malleostapedotomy in tympanosclerosis patients. (17524174)
2007
10
Influence of hypercalcemia in the formation of tympanosclerosis in rats. (16371843)
2006
11
Tympanosclerosis involving the ossicular chain: mobility of the stapes in association with hearing results. (16923708)
2006
12
Possible relationship between tympanosclerosis and atherosclerosis. (15267174)
2004
13
Asymptomatic tympanosclerosis. (11816394)
2002
14
Tympanosclerosis: long-term hearing results after ossicular reconstruction. (11956534)
2002
15
Experimental hematotympanum--aspects to the tympanosclerosis development. (12137309)
2002
16
Sex distribution in children with tympanosclerosis after insertion of a tympanostomy tube. (11271428)
2001
17
Minimal tympanosclerosis (cosmetic). (11816885)
2001
18
Long-term ventilating tube with tympanosclerosis. (11011482)
2000
19
Extensive tympanosclerosis with a fixed malleus. (10355190)
1999
20
Surgery of tympanosclerosis. (9425477)
1997
21
Tympanosclerosis-how we look at it. (23119284)
1997
22
Attic cholesteatoma and tympanosclerosis. (9210800)
1997
23
Surgical treatment of tympanosclerosis. (7718221)
1995
24
Tympanosclerosis and mini grommets: the relevance of grommet design. (7499941)
1995
25
Tympanic membrane perforation and tympanosclerosis with ossicular fixation. (8076533)
1994
26
Dry central tympanic membrane perforation and tympanosclerosis. (8313857)
1993
27
Tympanosclerosis. (8877197)
1993
28
Development of tympanosclerosis in children with otitis media with effusion and ventilation tubes. (1919311)
1991
29
Aspirating middle ear effusions when inserting ventilation tubes: does it influence post-operative otorrhoea, tube obstruction or the development of tympanosclerosis? (1742892)
1991
30
The significance of calcium antagonists in rat experimental tympanosclerosis. (3551898)
1987
31
Type II collagen mediated autoimmune middle ear disease: eustachian tube disease, otitis media with effusion and tympanosclerosis. (3835948)
1985
32
Prospective study of tympanosclerosis developing after grommet insertion. (6470572)
1984
33
Tympanosclerosis: clinical implications of the theory of pathogenesis. (6660756)
1983
34
Clinicopathologic studies in tympanosclerosis. (7055238)
1982
35
The ultrastructure of tympanosclerosis. The source of the matrix vesicles and the pattern of calcospherules. (7304723)
1981
36
Tympanosclerosis. A theory of pathogenesis. (6775569)
1980
37
Surgical treatment of tympanosclerosis. (703456)
1978
38
President's address. Tympanosclerosis. (1265007)
1976
39
Tympanosclerosis. (4687166)
1973
40
Histology of tympanosclerosis. (4110701)
1972
41
Tympanosclerosis. (4636824)
1972
42
Tympanosclerosis. (4996152)
1971
43
The pathology of tympanosclerosis. (5416456)
1970
44
Relation of otitis media chronica secretorica to tympanosclerosis. (5261124)
1969
45
Tympanosclerosis. (5782678)
1969
46
Tympanosclerosis. Electron microscopic study. (4908183)
1969
47
Tympanosclerosis. (5882309)
1965
48
TYMPANOSCLEROSIS. (14059349)
1963
49
Tympanosclerosis. (13964950)
1963
50
Tympanosclerosis--a revived clinocopathologic entity. (13904842)
1961

Variations for Tympanosclerosis

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Expression for genes affiliated with Tympanosclerosis

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Search GEO for disease gene expression data for Tympanosclerosis.

Pathways for genes affiliated with Tympanosclerosis

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Pathways related to Tympanosclerosis according to GeneCards Suite gene sharing:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
TGF-beta signaling pathway (KEGG)
Show member pathways
9.2
29.1TLR4, TNF
3
Show member pathways
9.1TLR4, TNF
49.1TLR4, TNF
59.1TLR4, TNF
69.1TLR4, TNF
79.1TLR4, TNF
89.1TLR4, TNF
99.1TLR4, TNF
109.1TLR4, TNF
119.1TLR4, TNF
129.0CALCA, TNF
13
Show member pathways
8.7BMP2, TLR4, TNF

GO Terms for genes affiliated with Tympanosclerosis

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Cellular components related to Tympanosclerosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:00099868.7BMP2, TLR4, TNF

Biological processes related to Tympanosclerosis according to GeneCards Suite gene sharing:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of ossificationGO:00457789.9BMP2, CALCA
2negative regulation of osteoclast differentiationGO:00456719.8CALCA, TLR4
3defense response to Gram-negative bacteriumGO:00508299.8CALCA, TLR4
4positive regulation of chemokine productionGO:00327229.7TLR4, TNF
5positive regulation of interleukin-8 biosynthetic processGO:00454169.7TLR4, TNF
6extrinsic apoptotic signaling pathwayGO:00971919.7TLR4, TNF
7positive regulation of interferon-gamma productionGO:00327299.7TLR4, TNF
8positive regulation of NF-kappaB import into nucleusGO:00423469.7TLR4, TNF
9I-kappaB kinase/NF-kappaB signalingGO:00072499.7TLR4, TNF
10lipopolysaccharide-mediated signaling pathwayGO:00316639.7TLR4, TNF
11negative regulation of interleukin-6 productionGO:00327159.6TLR4, TNF
12cellular response to organic cyclic compoundGO:00714079.5BMP2, TNF
13cellular response to lipopolysaccharideGO:00712229.5TLR4, TNF
14positive regulation of interleukin-6 productionGO:00327559.5TLR4, TNF
15positive regulation of nitric oxide biosynthetic processGO:00454299.4TLR4, TNF
16defense response to Gram-positive bacteriumGO:00508309.3CALCA, TNF
17positive regulation of JNK cascadeGO:00463309.2TLR4, TNF
18positive regulation of interleukin-8 productionGO:00327579.0CALCA, TLR4, TNF
19inflammatory responseGO:00069548.9BMP2, CALCA, TNF
20positive regulation of ERK1 and ERK2 cascadeGO:00703748.7BMP2, TLR4, TNF
21activation of MAPK activityGO:00001878.7BMP2, TLR4, TNF
22positive regulation of gene expressionGO:00106288.6BMP2, TLR4, TNF
23negative regulation of transcription, DNA-templatedGO:00458928.6BMP2, CALCA, TNF

Sources for Tympanosclerosis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet