Aliases & Classifications for Tympanosclerosis

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Aliases & Descriptions for Tympanosclerosis:

Name: Tympanosclerosis 10 12 65

Classifications:



External Ids:

Disease Ontology10 DOID:1214
ICD9CM29 385.09
SNOMED-CT59 111540000
ICD1027 H74.0
UMLS65 C0155477, C0395887

Summaries for Tympanosclerosis

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Wikipedia:68 Tympanosclerosis (also known as myringosclerosis or intratympanic tympanosclerosis) is a condition... more...

MalaCards based summary: Tympanosclerosis is related to otitis media and anti-hla hyperimmunization, and has symptoms including tympanic membrane hyperaemia An important gene associated with Tympanosclerosis is BMP2 (Bone Morphogenetic Protein 2), and among its related pathways are TGF-beta signaling pathway (KEGG) and Rheumatoid arthritis. Affiliated tissues include liver, prostate and bone.

Related Diseases for Tympanosclerosis

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Diseases related to Tympanosclerosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 66)
idRelated DiseaseScoreTop Affiliating Genes
1otitis media10.3
2anti-hla hyperimmunization10.2TLR4, TNF
3spondylocamptodactyly10.2TLR4, TNF
4rubeosis iridis10.2TLR4, TNF
5auricular cancer10.2TLR4, TNF
6ileocolitis10.2TLR4, TNF
7idiopathic spinal cord herniation10.2TLR4, TNF
8trench fever10.2TLR4, TNF
9sarcoidosis, early-onset10.1TLR4, TNF
10liver lipoma10.1BMP2, TNF
11basilar artery occlusion10.1TLR4, TNF
12submandibular gland disease10.1TLR4, TNF
13periodontal disease10.1TLR4, TNF
14cholesteatoma10.1
15common cold10.1TLR4, TNF
16trachoma10.1TLR4, TNF
17leech infestation10.1TLR4, TNF
18porphyria10.1TLR4, TNF
19funisitis10.1TLR4, TNF
20acute gonococcal epididymo-orchitis10.1TLR4, TNF
21meningitis10.1TLR4, TNF
22hypoglycemic coma10.1TLR4, TNF
23methylmalonic acidemia10.1TLR4, TNF
24necatoriasis10.1TLR4, TNF
25commensal bacterial infectious disease10.1TLR4, TNF
26atherosclerosis10.1
27hard palate cancer10.1TLR4, TNF
28carotenemia10.1TLR4, TNF
29liver leiomyosarcoma10.0TLR4, TNF
30multiple symmetric lipomatosis10.0TLR4, TNF
31mucocele of appendix10.0BMP2, CALCA
32chronic cystitis10.0TLR4, TNF
33diffuse scleroderma10.0TLR4, TNF
34congenital disorder of glycosylation, type ih10.0TLR4, TNF
35severe acute respiratory syndrome10.0TLR4, TNF
36chromosomal disease10.0BMP2, CALCA
37bone development disease10.0BMP2, CALCA
38pneumonia10.0
39liver fibroma10.0TLR4, TNF
40rectum signet ring adenocarcinoma10.0TLR4, TNF
41progressive deafness with stapes fixation10.0
42diabetic neuropathy10.0CALCA, TLR4
43neurogenic bladder9.9TLR4, TNF
44neonatal respiratory failure9.9TLR4, TNF
45intermediate dend syndrome9.9CALCA, TNF
46accessory nerve disease9.9TLR4, TNF
47peripheral retinal degeneration9.9CALCA, TNF
48benign focal amyotrophy9.9CALCA, TNF
49tracheal stenosis9.8CALCA, TNF
50meningeal melanomatosis9.8TLR4, TNF

Graphical network of the top 20 diseases related to Tympanosclerosis:



Diseases related to tympanosclerosis

Symptoms for Tympanosclerosis

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UMLS symptoms related to Tympanosclerosis:


tympanic membrane hyperaemia

Drugs & Therapeutics for Tympanosclerosis

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Interventional clinical trials:

idNameStatusNCT IDPhase
1Gas Supply, Demand and Middle Ear Gas Balance: Specific Aim 3cCompletedNCT00422851

Search NIH Clinical Center for Tympanosclerosis

Genetic Tests for Tympanosclerosis

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Anatomical Context for Tympanosclerosis

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MalaCards organs/tissues related to Tympanosclerosis:

33
Liver, Prostate, Bone, B cells, Brain, Endothelial, Breast

Animal Models for Tympanosclerosis or affiliated genes

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Publications for Tympanosclerosis

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Articles related to Tympanosclerosis:

(show top 50)    (show all 141)
idTitleAuthorsYear
1
The effect of stapes fixation on hearing results in tympanosclerosis treated by mobilization. (25472817)
2014
2
Morphological Alterations in the Tympanic Membrane Affected by Tympanosclerosis: Ultrastructural Study. (24134073)
2013
3
Expressions of TGF-I^1 and MMP-9 in a guinea pig model of tympanosclerosis: possible role in the pathogenesis of this disorder. (22777961)
2012
4
Could Helicobacter pylori play a role in the aetiopathogenesis of tympanosclerosis? (21888743)
2011
5
Serum matrix metalloproteinases and tympanosclerosis. (20955636)
2011
6
Does exogenous nitric oxide influence tympanosclerosis? An experimental study. (18945497)
2008
7
The effect of topical doxycycline in the prevention of experimental tympanosclerosis. (18388770)
2008
8
Management of tympanosclerosis with ossicular fixation: review and presentation of long-term results of 30 new cases. (17963670)
2007
9
Influence of hypercalcemia in the formation of tympanosclerosis in rats. (16371843)
2006
10
Tympanosclerosis involving the ossicular chain: mobility of the stapes in association with hearing results. (16923708)
2006
11
Possible relationship between tympanosclerosis and atherosclerosis. (15267174)
2004
12
Asymptomatic tympanosclerosis. (11816394)
2002
13
Tympanosclerosis: long-term hearing results after ossicular reconstruction. (11956534)
2002
14
Experimental hematotympanum--aspects to the tympanosclerosis development. (12137309)
2002
15
Sex distribution in children with tympanosclerosis after insertion of a tympanostomy tube. (11271428)
2001
16
Minimal tympanosclerosis (cosmetic). (11816885)
2001
17
Long-term ventilating tube with tympanosclerosis. (11011482)
2000
18
Extensive tympanosclerosis with a fixed malleus. (10355190)
1999
19
Surgery of tympanosclerosis. (9425477)
1997
20
Tympanosclerosis-how we look at it. (23119284)
1997
21
Attic cholesteatoma and tympanosclerosis. (9210800)
1997
22
Surgical treatment of tympanosclerosis. (7718221)
1995
23
Tympanosclerosis and mini grommets: the relevance of grommet design. (7499941)
1995
24
Tympanic membrane perforation and tympanosclerosis with ossicular fixation. (8076533)
1994
25
Dry central tympanic membrane perforation and tympanosclerosis. (8313857)
1993
26
Tympanosclerosis. (8877197)
1993
27
Development of tympanosclerosis in children with otitis media with effusion and ventilation tubes. (1919311)
1991
28
Aspirating middle ear effusions when inserting ventilation tubes: does it influence post-operative otorrhoea, tube obstruction or the development of tympanosclerosis? (1742892)
1991
29
The significance of calcium antagonists in rat experimental tympanosclerosis. (3551898)
1987
30
Type II collagen mediated autoimmune middle ear disease: eustachian tube disease, otitis media with effusion and tympanosclerosis. (3835948)
1985
31
Prospective study of tympanosclerosis developing after grommet insertion. (6470572)
1984
32
Tympanosclerosis: clinical implications of the theory of pathogenesis. (6660756)
1983
33
Clinicopathologic studies in tympanosclerosis. (7055238)
1982
34
The ultrastructure of tympanosclerosis. The source of the matrix vesicles and the pattern of calcospherules. (7304723)
1981
35
Tympanosclerosis. A theory of pathogenesis. (6775569)
1980
36
Surgical treatment of tympanosclerosis. (703456)
1978
37
President's address. Tympanosclerosis. (1265007)
1976
38
Tympanosclerosis. (4687166)
1973
39
Histology of tympanosclerosis. (4110701)
1972
40
Tympanosclerosis. (4636824)
1972
41
Tympanosclerosis. (4996152)
1971
42
The pathology of tympanosclerosis. (5416456)
1970
43
Relation of otitis media chronica secretorica to tympanosclerosis. (5261124)
1969
44
Tympanosclerosis. (5782678)
1969
45
Tympanosclerosis. Electron microscopic study. (4908183)
1969
46
Tympanosclerosis. (5882309)
1965
47
TYMPANOSCLEROSIS. (14059349)
1963
48
Tympanosclerosis. (13964950)
1963
49
Tympanosclerosis--a revived clinocopathologic entity. (13904842)
1961
50

Variations for Tympanosclerosis

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Expression for genes affiliated with Tympanosclerosis

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Search GEO for disease gene expression data for Tympanosclerosis.

Pathways for genes affiliated with Tympanosclerosis

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GO Terms for genes affiliated with Tympanosclerosis

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Biological processes related to Tympanosclerosis according to GeneCards Suite gene sharing:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of interleukin-8 biosynthetic processGO:004541610.0TLR4, TNF
2positive regulation of chemokine productionGO:003272210.0TLR4, TNF
3positive regulation of NF-kappaB import into nucleusGO:004234610.0TLR4, TNF
4cellular response to organic cyclic compoundGO:00714079.9BMP2, TNF
5negative regulation of interleukin-6 productionGO:00327159.9TLR4, TNF
6positive regulation of interferon-gamma productionGO:00327299.8TLR4, TNF
7organ morphogenesisGO:00098879.8BMP2, TNF
8positive regulation of ossificationGO:00457789.7BMP2, CALCA
9positive regulation of protein phosphorylationGO:00019349.7BMP2, TNF
10positive regulation of interleukin-8 productionGO:00327579.6CALCA, TLR4
11positive regulation of apoptotic processGO:00430659.6BMP2, TNF
12negative regulation of osteoclast differentiationGO:00456719.6CALCA, TLR4
13extrinsic apoptotic signaling pathwayGO:00971919.6TLR4, TNF
14I-kappaB kinase/NF-kappaB signalingGO:00072499.6TLR4, TNF
15positive regulation of interleukin-6 productionGO:00327559.6TLR4, TNF
16negative regulation of gene expressionGO:00106299.5BMP2, TNF
17defense response to Gram-negative bacteriumGO:00508299.4CALCA, TLR4
18cellular response to lipopolysaccharideGO:00712229.3TLR4, TNF
19activation of MAPK activityGO:00001879.3BMP2, TLR4, TNF
20defense response to bacteriumGO:00427429.2TLR4, TNF
21positive regulation of transcription from RNA polymerase II promoterGO:00459448.9BMP2, TLR4, TNF
22negative regulation of transcription, DNA-templatedGO:00458928.8BMP2, CALCA, TNF
23inflammatory responseGO:00069548.6BMP2, CALCA, TNF

Sources for Tympanosclerosis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet