MCID: TYM001
MIFTS: 46

Tympanosclerosis malady

Ear diseases category
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Summaries for Tympanosclerosis

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Wikipedia:65 Tympanosclerosis (also known as myringosclerosis or intratympanic tympanosclerosis) is a condition... more...

MalaCards based summary: Tympanosclerosis is related to pneumonia and atherosclerosis. An important gene associated with Tympanosclerosis is BMP2 (bone morphogenetic protein 2), and among its related pathways are Adipogenesis and TGF-beta Signaling Pathway. The compounds fibroin and methylmethacrylate have been mentioned in the context of this disorder. Affiliated tissues include bone, and related mouse phenotypes are hearing/vestibular/ear and limbs/digits/tail.

Aliases & Classifications for Tympanosclerosis

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Tympanosclerosis, Aliases & Descriptions:

Name: Tympanosclerosis 8 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Ear diseases


External Ids:

Disease Ontology8 DOID:1214
ICD9CM27 385.09
SNOMED-CT57 111540000
ICD1025 H74.0

Related Diseases for Tympanosclerosis

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Diseases related to Tympanosclerosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 48)
idRelated DiseaseScoreTop Affiliating Genes
1pneumonia29.9TNF, TLR4
2atherosclerosis29.6BMP2, TNF, TLR4, SPP1
3otitis media10.5
4trigeminal neuralgia10.4BMP2
5complex regional pain syndrome10.4CALCA
6blau syndrome10.4TNF
7synovitis10.4TNF
8coronary restenosis10.4SPP1
9calcinosis10.3SPP1
10cholesteatoma10.3
11pyelonephritis10.3TLR4
12arthropathy10.2BMP2, TNF
13aortic valve stenosis10.2SPP1, BMP2
14hyperphosphatemia10.1BMP2, SPP1
15bone cancer10.1BMP2, SPP1
16papillary thyroid carcinoma10.1SPP1, CALCA
17spondylarthropathy10.1TLR4, TNF
18chorioamnionitis10.0TNF, TLR4
19ankylosing spondylitis10.0TLR4, TNF
20carotid stenosis10.0
21hypercalcemia10.0
22eustachian tube disease10.0
23middle ear disease10.0
24suppurative otitis media10.0
25deafness, progressive with stapes fixation10.0
26periodontitis10.0TNF, TLR4
27monocytic leukemia10.0TNF, TLR4
28septic shock10.0TNF, TLR4
29primary hyperoxaluria10.0SPP1, TNF
30hypersensitivity reaction type ii disease10.0TNF, TLR4
31secondary syphilis10.0SPP1, BMP2, CALCA
32diabetes mellitus10.0TNF, BMP2, CALCA
33osteoporosis9.9SPP1, BMP2, CALCA
34galactosemia9.9TNF, TLR4
35hepatitis c9.9TLR4, TNF
36colitis9.9TNF, TLR4
37atopic dermatitis9.8TLR4, TNF
38sepsis9.8CALCA, TNF, TLR4
39periodontal disease9.8TNF, TLR4, SPP1
40congenital heart disease9.8SPP1, TLR4, TNF
41stomach cancer9.8SPP1, TLR4, BMP2
42systemic lupus erythematosus9.8TNF, TLR4, SPP1
43osteoarthritis9.7SPP1, TNF, BMP2, CALCA
44lung cancer9.7SPP1, TLR4, BMP2
45arthritis9.6TLR4, TNF, BMP2, CALCA
46rheumatoid arthritis9.6BMP2, TNF, TLR4, SPP1
47melanoma9.6BMP2, TNF, TLR4, SPP1
48leukemia9.6TLR4, TNF, BMP2

Graphical network of the top 20 diseases related to Tympanosclerosis:



Diseases related to tympanosclerosis

Symptoms for Tympanosclerosis

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Drugs & Therapeutics for Tympanosclerosis

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Drug clinical trials:

Search ClinicalTrials for Tympanosclerosis

Search NIH Clinical Center for Tympanosclerosis

Genetic Tests for Tympanosclerosis

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Anatomical Context for Tympanosclerosis

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MalaCards organs/tissues related to Tympanosclerosis:

32
Bone

Animal Models for Tympanosclerosis or affiliated genes

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Publications for Tympanosclerosis

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Articles related to Tympanosclerosis:

(show top 50)    (show all 131)
idTitleAuthorsYear
1
Morphological Alterations in the Tympanic Membrane Affected by Tympanosclerosis: Ultrastructural Study. (24134073)
2013
2
Expressions of TGF-I^1 and MMP-9 in a guinea pig model of tympanosclerosis: possible role in the pathogenesis of this disorder. (22777961)
2012
3
Could Helicobacter pylori play a role in the aetiopathogenesis of tympanosclerosis? (21888743)
2011
4
Serum matrix metalloproteinases and tympanosclerosis. (20955636)
2011
5
Does exogenous nitric oxide influence tympanosclerosis? An experimental study. (18945497)
2008
6
The effect of topical doxycycline in the prevention of experimental tympanosclerosis. (18388770)
2008
7
Management of tympanosclerosis with ossicular fixation: review and presentation of long-term results of 30 new cases. (17963670)
2007
8
Malleostapedotomy in tympanosclerosis patients. (17524174)
2007
9
Influence of hypercalcemia in the formation of tympanosclerosis in rats. (16371843)
2006
10
Tympanosclerosis involving the ossicular chain: mobility of the stapes in association with hearing results. (16923708)
2006
11
Possible relationship between tympanosclerosis and atherosclerosis. (15267174)
2004
12
Asymptomatic tympanosclerosis. (11816394)
2002
13
Tympanosclerosis: long-term hearing results after ossicular reconstruction. (11956534)
2002
14
Experimental hematotympanum--aspects to the tympanosclerosis development. (12137309)
2002
15
Sex distribution in children with tympanosclerosis after insertion of a tympanostomy tube. (11271428)
2001
16
Minimal tympanosclerosis (cosmetic). (11816885)
2001
17
Long-term ventilating tube with tympanosclerosis. (11011482)
2000
18
Extensive tympanosclerosis with a fixed malleus. (10355190)
1999
19
Tympanosclerosis with squamous epithelium in the tympanum. (10388186)
1999
20
Surgery of tympanosclerosis. (9425477)
1997
21
Tympanosclerosis-how we look at it. (23119284)
1997
22
Attic cholesteatoma and tympanosclerosis. (9210800)
1997
23
Surgical treatment of tympanosclerosis. (7718221)
1995
24
Tympanosclerosis and mini grommets: the relevance of grommet design. (7499941)
1995
25
Tympanic membrane perforation and tympanosclerosis with ossicular fixation. (8076533)
1994
26
Dry central tympanic membrane perforation and tympanosclerosis. (8313857)
1993
27
Tympanosclerosis. (8877197)
1993
28
Development of tympanosclerosis in children with otitis media with effusion and ventilation tubes. (1919311)
1991
29
Aspirating middle ear effusions when inserting ventilation tubes: does it influence post-operative otorrhoea, tube obstruction or the development of tympanosclerosis? (1742892)
1991
30
The significance of calcium antagonists in rat experimental tympanosclerosis. (3551898)
1987
31
Type II collagen mediated autoimmune middle ear disease: eustachian tube disease, otitis media with effusion and tympanosclerosis. (3835948)
1985
32
Prospective study of tympanosclerosis developing after grommet insertion. (6470572)
1984
33
Tympanosclerosis: clinical implications of the theory of pathogenesis. (6660756)
1983
34
Clinicopathologic studies in tympanosclerosis. (7055238)
1982
35
The ultrastructure of tympanosclerosis. The source of the matrix vesicles and the pattern of calcospherules. (7304723)
1981
36
Tympanosclerosis. A theory of pathogenesis. (6775569)
1980
37
Surgical treatment of tympanosclerosis. (703456)
1978
38
President's address. Tympanosclerosis. (1265007)
1976
39
Tympanosclerosis. (4687166)
1973
40
Histology of tympanosclerosis. (4110701)
1972
41
Tympanosclerosis. (4636824)
1972
42
Tympanosclerosis. (4996152)
1971
43
The pathology of tympanosclerosis. (5416456)
1970
44
Relation of otitis media chronica secretorica to tympanosclerosis. (5261124)
1969
45
Tympanosclerosis. (5782678)
1969
46
Tympanosclerosis. Electron microscopic study. (4908183)
1969
47
Tympanosclerosis. (5882309)
1965
48
TYMPANOSCLEROSIS. (14059349)
1963
49
Tympanosclerosis. (13964950)
1963
50
Tympanosclerosis--a revived clinocopathologic entity. (13904842)
1961

Variations for Tympanosclerosis

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Expression for genes affiliated with Tympanosclerosis

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Expression patterns in normal tissues for genes affiliated with Tympanosclerosis

Search GEO for disease gene expression data for Tympanosclerosis.

Pathways for genes affiliated with Tympanosclerosis

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Pathways related to Tympanosclerosis according to GeneCards/GeneDecks:

(show all 28)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5TNF, BMP2
2
Show member pathways
9.5TNF, BMP2
39.4SPP1, BMP2
49.3TNF, SPP1
59.1TLR4, TNF
69.1TNF, TLR4
7
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
9.1TLR4, TNF
8
Show member pathways
Immune response MIF in innate immunity response60
9.1TNF, TLR4
9
Show member pathways
9.1TNF, TLR4
109.1TLR4, TNF
119.1TNF, TLR4
129.1TLR4, TNF
139.1TLR4, TNF
149.1TNF, TLR4
159.1TLR4, TNF
16
Show member pathways
9.1TNF, TLR4
179.1TNF, TLR4
189.1TLR4, TNF
19
Show member pathways
9.1TLR4, TNF
209.1TNF, TLR4
21
Show member pathways
IL27-mediated signaling events37
9.1TNF, TLR4
22
Show member pathways
8.9BMP2, TNF, SPP1
238.8SPP1, TNF, CALCA
24
Show member pathways
8.7TLR4, TNF, BMP2
25
Show member pathways
8.7TNF, TLR4, BMP2
26
Show member pathways
8.7TNF, TLR4, BMP2
27
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
8.5TLR4, TNF, SPP1
28
Show member pathways
8.5SPP1, TNF, TLR4

Compounds for genes affiliated with Tympanosclerosis

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Compounds related to Tympanosclerosis according to GeneCards/GeneDecks:

(show top 50)    (show all 83)
idCompoundScoreTop Affiliating Genes
1fibroin449.8SPP1, BMP2
2methylmethacrylate449.8SPP1, BMP2
3zoledronic acid449.8BMP2, CALCA
4alizarin449.8BMP2, SPP1
5alendronate44 50 1111.8BMP2, CALCA
6chitosan449.8SPP1, BMP2
7titanium449.7BMP2, SPP1
8alginate449.7SPP1, BMP2
925-hydroxyvitamin d449.5SPP1, CALCA
10d-galactosamine449.5TNF, TLR4
11zymosan449.5TLR4, TNF
12imiquimod44 61 28 1112.5TLR4, TNF
13phosphorus449.4SPP1, CALCA
14polymyxin b449.4TLR4, TNF
15lipoteichoic acid449.4TLR4, TNF
16fluoride449.4SPP1, CALCA
17polyinosinic-polycytidylic acid449.4TNF, TLR4
182,5-oligoadenylate449.3TLR4, TNF
191,25 dihydroxy vitamin d3449.3CALCA, SPP1, BMP2
20pd 98,059449.2BMP2, TNF, SPP1
21il 10449.1TNF, TLR4
22atorvastatin44 50 28 24 1113.1TLR4, BMP2, TNF
23simvastatin44 50 61 28 24 1114.1TLR4, BMP2, TNF
24poly(i-c)449.0TLR4, TNF
25mycophenolate mofetil44 50 1111.0SPP1, TNF
26histamine44 28 2411.0CALCA, TNF, TLR4
27infliximab44 50 1110.9TNF, TLR4, SPP1
28wortmannin448.9TLR4, BMP2, SPP1
29creatinine448.9BMP2, CALCA, SPP1
30fibrinogen448.9TNF, SPP1, TLR4
31ly294002448.8TLR4, TNF, SPP1
32indomethacin44 28 61 1111.8TNF, SPP1, BMP2, CALCA
33superoxide44 249.7TNF, SPP1, TLR4
34nitric oxide44 24 1110.5CALCA, TLR4, BMP2, TNF
35tgf beta1448.5BMP2, TNF, TLR4, SPP1
36tacrolimus44 50 1110.5TLR4, TNF, BMP2, SPP1
37sb 20358044 619.5BMP2, TNF, TLR4, SPP1
38vitamin d448.5BMP2, TLR4, SPP1, CALCA
39actinomycin d448.5BMP2, TLR4, SPP1, TNF
40genistein44 28 61 2 24 1113.5BMP2, SPP1, TLR4, TNF
41cycloheximide448.5BMP2, SPP1, TNF, TLR4
42dexamethasone44 50 28 1111.5TNF, TLR4, SPP1, BMP2
43retinoic acid44 249.4BMP2, SPP1, TLR4, TNF
44lipid448.4BMP2, TLR4, SPP1, TNF
45serine448.3TLR4, BMP2, SPP1, TNF
46calcitriol44 61 24 1111.0TNF, TLR4, CALCA, SPP1, BMP2
47cyclosporin a44 28 6110.0TLR4, CALCA, BMP2, SPP1, TNF
48pge2448.0TNF, CALCA, SPP1, TLR4, BMP2
49lactate448.0BMP2, TNF, SPP1, CALCA, TLR4
50vegf448.0BMP2, TNF, TLR4, SPP1, CALCA

GO Terms for genes affiliated with Tympanosclerosis

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Cellular components related to Tympanosclerosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055769.4BMP2, SPP1
2extracellular spaceGO:0056158.1CALCA, BMP2, TNF, SPP1

Biological processes related to Tympanosclerosis according to GeneCards/GeneDecks:

(show all 26)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of ossificationGO:0457789.8BMP2, CALCA
2cellular response to organic cyclic compoundGO:0714079.8BMP2, TNF
3organ morphogenesisGO:0098879.6TNF, BMP2
4embryo implantationGO:0075669.6SPP1, CALCA
5osteoblast differentiationGO:0016499.5BMP2, SPP1
6positive regulation of protein phosphorylationGO:0019349.5TNF, BMP2
7response to hypoxiaGO:0016669.5TNF, BMP2
8positive regulation of interleukin-8 biosynthetic processGO:0454169.5TNF, TLR4
9positive regulation of chemokine productionGO:0327229.5TNF, TLR4
10positive regulation of NF-kappaB import into nucleusGO:0423469.5TLR4, TNF
11negative regulation of osteoclast differentiationGO:0456719.5CALCA, TLR4
12positive regulation of interleukin-8 productionGO:0327579.5TLR4, CALCA
13negative regulation of interleukin-6 productionGO:0327159.4TNF, TLR4
14lipopolysaccharide-mediated signaling pathwayGO:0316639.4TLR4, TNF
15positive regulation of nitric oxide biosynthetic processGO:0454299.4TLR4, TNF
16positive regulation of interferon-gamma productionGO:0327299.4TLR4, TNF
17positive regulation of interleukin-6 productionGO:0327559.4TLR4, TNF
18positive regulation of JNK cascadeGO:0463309.3TLR4, TNF
19extracellular matrix organizationGO:0301989.2BMP2, SPP1, TNF
20negative regulation of transcription, DNA-templatedGO:0458929.2CALCA, TNF, BMP2
21activation of MAPK activityGO:0001879.0BMP2, TLR4, TNF
22positive regulation of ERK1 and ERK2 cascadeGO:0703749.0TLR4, BMP2, TNF
23positive regulation of NF-kappaB transcription factor activityGO:0510929.0TNF, TLR4
24positive regulation of I-kappaB kinase/NF-kappaB signalingGO:0431238.8TLR4, TNF
25positive regulation of transcription from RNA polymerase II promoterGO:0459448.7BMP2, TNF, TLR4
26inflammatory responseGO:0069548.7CALCA, BMP2, TNF, SPP1

Molecular functions related to Tympanosclerosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051258.9BMP2, TNF, SPP1

Products for genes affiliated with Tympanosclerosis

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Sources for Tympanosclerosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet