Aliases & Classifications for Tympanosclerosis

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Aliases & Descriptions for Tympanosclerosis:

Name: Tympanosclerosis 11 13 68

Classifications:



External Ids:

Disease Ontology11 DOID:1214
ICD9CM32 385.09
SNOMED-CT62 111540000
ICD1030 H74.0

Summaries for Tympanosclerosis

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Wikipedia:71 Tympanosclerosis (also known as myringosclerosis or intratympanic tympanosclerosis) is a condition... more...

MalaCards based summary: Tympanosclerosis is related to deafness, progressive, with stapes fixation and otitis media, and has symptoms including tympanic membrane hyperaemia An important gene associated with Tympanosclerosis is TLR4 (Toll Like Receptor 4), and among its related pathways are Rheumatoid arthritis and Pertussis. Affiliated tissues include bone.

Related Diseases for Tympanosclerosis

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Diseases related to Tympanosclerosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 65)
idRelated DiseaseScoreTop Affiliating Genes
1deafness, progressive, with stapes fixation10.8
2otitis media10.2
3antigen-peptide-transporter 2 deficiency10.2TLR4, TNF
4paraneoplastic polyneuropathy10.2TLR4, TNF
5spondylohypoplasia, arthrogryposis and popliteal pterygium10.2TLR4, TNF
6gastroduodenal crohn's disease10.2TLR4, TNF
7inner ear cancer10.2TLR4, TNF
8accessory nerve disease10.2TLR4, TNF
9acute cholangitis10.2TLR4, TNF
10bartonellosis10.2TLR4, TNF
11binocular vision disease10.2TLR4, TNF
12benign lymphoepithelial lesion of salivary gland10.2TLR4, TNF
13nasopharyngitis10.2TLR4, TNF
14corneal intraepithelial neoplasm10.2TLR4, TNF
15retroperitoneal fibrosis10.2TLR4, TNF
16neonatal period electroclinical syndrome10.1TLR4, TNF
17esophagus melanoma10.1TLR4, TNF
18cutaneous porphyria10.1TLR4, TNF
19dengue disease10.1TLR4, TNF
20gastric ulcer10.1TLR4, TNF
21diphtheria10.1TLR4, TNF
22mononeuritis of lower limb10.1TLR4, TNF
23lymphangioma10.1TLR4, TNF
24variola minor10.1TLR4, TNF
25keratosis10.1TLR4, TNF
26hemorrhagic fever with renal syndrome10.1TLR4, TNF
27heart septal defect10.1TLR4, TNF
28uterine inversion10.1TLR4, TNF
29deafness, autosomal recessive 6210.1TLR4, TNF
30motion sickness10.1TLR4, TNF
31rectum leiomyosarcoma10.1TLR4, TNF
32cryoglobulinemia10.1TLR4, TNF
33pleomorphic lipoma10.1BMP2, TNF
34atypical follicular adenoma10.0TLR4, TNF
35laryngeal tuberculosis10.0TLR4, TNF
36sheehan syndrome10.0TLR4, TNF
37foveal hypoplasia 110.0TLR4, TNF
38congenital disorder of glycosylation, type ih10.0TLR4, TNF
39cholesteatoma10.0
40perianal skin paget's disease10.0TLR4, TNF
41palmoplantar keratosis10.0TLR4, TNF
42low compliance bladder10.0TLR4, TNF
43lethal midline granuloma10.0TLR4, TNF
44atherosclerosis9.9
45chronic rhinitis9.9TLR4, TNF
46basaloid squamous cell carcinoma9.9TLR4, TNF
47physical disorder9.9BMP2, CALCA
48bone deterioration disease9.9BMP2, CALCA
49respiratory failure9.9TLR4, TNF
50pneumonia9.9

Graphical network of the top 20 diseases related to Tympanosclerosis:



Diseases related to tympanosclerosis

Symptoms & Phenotypes for Tympanosclerosis

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UMLS symptoms related to Tympanosclerosis:


tympanic membrane hyperaemia

Drugs & Therapeutics for Tympanosclerosis

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Interventional clinical trials:

idNameStatusNCT IDPhase
1Gas Supply, Demand and Middle Ear Gas Balance: Specific Aim 3cCompletedNCT00422851

Search NIH Clinical Center for Tympanosclerosis

Genetic Tests for Tympanosclerosis

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Anatomical Context for Tympanosclerosis

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MalaCards organs/tissues related to Tympanosclerosis:

36
Bone

Publications for Tympanosclerosis

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Articles related to Tympanosclerosis:

(show top 50)    (show all 145)
idTitleAuthorsYear
1
Tympanosclerosis Presenting as Mass: Workup and Differential. (27656306)
2016
2
The effect of melatonin and vitamin C treatment on the experimentally induced tympanosclerosis: study in rats. (27484331)
2016
3
Genetic polymorphisms affecting antioxidant enzymes are present in tympanosclerosis patients. (27534583)
2016
4
Neuroglial Choristoma of the Middle Ear with Massive Tympanosclerosis: A Case Report and Literature Review. (27942605)
2016
5
Ectopic Mineralization and Conductive Hearing Loss in Enpp1asj Mutant Mice, a New Model for Otitis Media and Tympanosclerosis. (27959908)
2016
6
An Analysis of Surgical Treatment Results of Patients With Tympanosclerosis. (26517462)
2015
7
Efficacy of pre-operative computed tomography evaluation of the tympanic cavity for hearing improvement after stapes surgery for tympanosclerosis with stapes fixation. (25706157)
2015
8
Does systemic clarithromycin therapy have an inhibitory effect on tympanosclerosis? An experimental animal study. (25619629)
2015
9
Correlation Between Tympanosclerosis and Helicobacter pylori. (26568799)
2015
10
Manubrio-stapedioplasty: new surgical technique for malleus and incus fixation due to tympanosclerosis. (25883094)
2015
11
Role of Chlamydia pneumoniae and Helicobacteria pylori in the development of tympanosclerosis. (25956614)
2015
12
Increased carotid artery intima-media thickness in patients with tympanosclerosis: Common risk factors with atherosclerosis? (25835276)
2015
13
Combining Use of Captopril and Losartan Attenuates the Progress of Streptococcus pneumoniae-Induced Tympanosclerosis through the Suppression of TGF-I^1 Expression. (25360706)
2014
14
The effect of stapes fixation on hearing results in tympanosclerosis treated by mobilization. (25472817)
2014
15
PAI-1 inhibits development of chronic otitis media and tympanosclerosis in a mouse model of otitis media. (25399881)
2014
16
Surgery of isolated malleus fixation due to tympanosclerosis. (25503358)
2014
17
Immunohistochemical investigation of inducible nitric oxide synthase, osteopontin, and calcium-sensing receptor in a myringosclerosis/tympanosclerosis model. (24136309)
2014
18
Morphological Alterations in the Tympanic Membrane Affected by Tympanosclerosis: Ultrastructural Study. (24134073)
2013
19
Expressions of TGF-I^1 and MMP-9 in a guinea pig model of tympanosclerosis: possible role in the pathogenesis of this disorder. (22777961)
2012
20
Experience with the Vibrant Soundbridge RW-Coupler for round window Vibroplasty with tympanosclerosis. (22385350)
2012
21
Assessment of Tumor Necrosis Factor alpha gene expression profile in selected structures of middle ear in patients with tympanosclerosis]. (23164102)
2012
22
Could Helicobacter pylori play a role in the aetiopathogenesis of tympanosclerosis? (21888743)
2011
23
Serum matrix metalloproteinases and tympanosclerosis. (20955636)
2011
24
Clinical analysis of intratympanic tympanosclerosis: etiology, ossicular chain findings, and hearing results of surgery. (19685361)
2010
25
Tympanosclerosis and our surgical results. (19771442)
2010
26
Evaluation of the polymorphism in the Toll-like receptor 4 (TLR4) genes of tympanosclerosis patients. (19398177)
2010
27
Is there any relation between coronary atherosclerosis and tympanosclerosis? (20382609)
2010
28
Hearing results of surgery for tympanosclerosis. (18704475)
2009
29
Expression and localization of macrophages and BMP2 in mucosa of tympanosclerosis]. (19670606)
2009
30
A computational method for the semi-automated quantitative analysis of tympanic membrane perforations and tympanosclerosis. (19643399)
2009
31
The effect of topical doxycycline in the prevention of experimental tympanosclerosis. (18388770)
2008
32
The effect of stapes mobility on hearing outcome and which procedure to choose in fixed stapes in children tympanosclerosis. (18394718)
2008
33
Evaluation of plasma fibronectine level as a probable indicator for tympanosclerosis. (17470306)
2008
34
Topical application of calcium channel blockers to reduce the progression of experimentally induced myringosclerosis and tympanosclerosis. (18176349)
2008
35
Does exogenous nitric oxide influence tympanosclerosis? An experimental study. (18945497)
2008
36
Analysis of long-term hearing after tympanosclerosis with total/partial stapedectomy and prosthesis used. (18607937)
2008
37
Stapedectomy in tympanosclerosis, hearing results. (18454228)
2008
38
Management of tympanosclerosis with ossicular fixation: review and presentation of long-term results of 30 new cases. (17963670)
2007
39
Malleostapedotomy in tympanosclerosis patients. (17524174)
2007
40
Tympanosclerosis involving the ossicular chain: mobility of the stapes in association with hearing results. (16923708)
2006
41
Influence of hypercalcemia in the formation of tympanosclerosis in rats. (16371843)
2006
42
Tympanosclerosis revisited. (23120263)
2006
43
Possible relationship between tympanosclerosis and atherosclerosis. (15267174)
2004
44
Comparison of free radicals and antioxidant enzymes in chronic otitis media with and without tympanosclerosis. (14710000)
2004
45
An analysis of the single-stage tympanoplasty with over-underlay grafting in tympanosclerosis. (15129093)
2004
46
Is carotid stenosis correlated with tympanosclerosis. (15507892)
2004
47
Long-term ventilating tube with tympanosclerosis. (12610892)
2003
48
Tympanosclerosis: long-term hearing results after ossicular reconstruction. (11956534)
2002
49
Experimental hematotympanum--aspects to the tympanosclerosis development. (12137309)
2002
50
Possible inflammatory mediators in tympanosclerosis development. (11955606)
2002

Variations for Tympanosclerosis

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Expression for genes affiliated with Tympanosclerosis

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Search GEO for disease gene expression data for Tympanosclerosis.

Pathways for genes affiliated with Tympanosclerosis

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GO Terms for genes affiliated with Tympanosclerosis

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Cellular components related to Tympanosclerosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:00099868.9BMP2, TLR4, TNF

Biological processes related to Tympanosclerosis according to GeneCards Suite gene sharing:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1apoptotic signaling pathwayGO:009719010.1TLR4, TNF
2I-kappaB kinase/NF-kappaB signalingGO:000724910.1TLR4, TNF
3lipopolysaccharide-mediated signaling pathwayGO:003166310.1TLR4, TNF
4negative regulation of interleukin-6 productionGO:003271510.1TLR4, TNF
5positive regulation of chemokine productionGO:003272210.1TLR4, TNF
6cellular response to organic cyclic compoundGO:007140710.1BMP2, TNF
7positive regulation of interferon-gamma productionGO:003272910.0TLR4, TNF
8positive regulation of interleukin-6 productionGO:003275510.0TLR4, TNF
9positive regulation of interleukin-8 biosynthetic processGO:004541610.0TLR4, TNF
10positive regulation of interleukin-8 productionGO:003275710.0TLR4, TNF
11positive regulation of JNK cascadeGO:00463309.9TLR4, TNF
12positive regulation of NF-kappaB import into nucleusGO:00423469.9TLR4, TNF
13positive regulation of nitric oxide biosynthetic processGO:00454299.7TLR4, TNF
14activation of MAPK activityGO:00001879.6BMP2, TLR4, TNF
15positive regulation of ERK1 and ERK2 cascadeGO:00703749.5BMP2, TLR4, TNF
16positive regulation of gene expressionGO:00106289.5BMP2, TLR4, TNF
17negative regulation of transcription, DNA-templatedGO:00458929.2BMP2, CALCA, TNF
18positive regulation of ossificationGO:00457789.1BMP2, CALCA
19inflammatory responseGO:00069548.8BMP2, CALCA, TLR4, TNF

Sources for Tympanosclerosis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet