MCID: TYM001
MIFTS: 39

Tympanosclerosis malady

Ear diseases category

Summaries for Tympanosclerosis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Tympanosclerosis (also known as myringosclerosis or intratympanic tympanosclerosis) is a condition... more...

MalaCards: Tympanosclerosis is related to otitis media and cholesteatoma. An important gene associated with Tympanosclerosis is BMP2 (bone morphogenetic protein 2), and among its related pathways are BDNF signaling pathway and Transcription Role of VDR in regulation of genes involved in osteoporosis. The compounds zoledronic acid and alendronate have been mentioned in the context of this disorder. Affiliated tissues include bone, and related mouse phenotypes are hearing/vestibular/ear and skeleton.

Aliases & Classifications for Tympanosclerosis

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Sources:
8Disease Ontology, 60UMLS, 27ICD9CM, 56SNOMED-CT, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Ear diseases


Aliases & Descriptions:

tympanosclerosis 8 60


External Ids:

Disease Ontology8 DOID:1214
ICD9CM27 385.09
SNOMED-CT56 111540000
ICD1025 H74.0

Related Diseases for Tympanosclerosis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Tympanosclerosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 53)
idRelated DiseaseScoreTop Affiliating Genes
1otitis media10.4
2cholesteatoma10.3
3atherosclerosis10.1
4hemochromatosis10.0BMP2
5diarrhea10.0CALCA
6trigeminal neuralgia10.0BMP2
7hypertension10.0CALCA
8sarcoma10.0BMP2
9ankylosis10.0BMP2
10pancreatic cancer10.0BMP2
11root resorption10.0BMP2
12thyroiditis10.0CALCA
13periodontitis10.0TLR4
14osteomyelitis10.0BMP2
15pyelonephritis10.0TLR4
16osteonecrosis10.0BMP2
17inflammatory bowel disease10.0TLR4
18insulin resistance10.0TLR4
19calcinosis10.0SPP1
20rhabdoid tumor10.0SPP1
21nephrolithiasis10.0SPP1
22galactosemia10.0TLR4
23diabetes mellitus10.0BMP2, CALCA
24primary hyperoxaluria10.0SPP1
25adenoma10.0TLR4, CALCA
26uremia10.0SPP1
27arteriosclerosis10.0SPP1
28myeloma10.0SPP1, BMP2
29aortic valve stenosis10.0SPP1, BMP2
30hyperphosphatemia10.0BMP2, SPP1
31bone carcinoma10.0BMP2, SPP1
32ovarian cancer10.0SPP1, BMP2
33adenocarcinoma10.0SPP1, BMP2
34papillary thyroid carcinoma10.0SPP1, CALCA
35periodontal disease10.0TLR4, SPP1
36prostate cancer10.0SPP1, BMP2
37osteosarcoma10.0SPP1, BMP2
38arthritis10.0TLR4, BMP2, CALCA
39secondary syphilis10.0SPP1, BMP2, CALCA
40osteoarthritis10.0SPP1, BMP2, CALCA
41osteoporosis10.0SPP1, CALCA, BMP2
42rheumatoid arthritis10.0TLR4, BMP2, SPP1
43stomach cancer10.0TLR4, BMP2, SPP1
44melanoma10.0TLR4, BMP2, SPP1
45congenital heart defect10.0TLR4, SPP1
46lung cancer10.0TLR4, SPP1, BMP2
47carotid stenosis10.0
48hypercalcemia10.0
49collagen disease10.0
50eustachian tube disease10.0

Graphical network of the top 20 diseases related to Tympanosclerosis:



Diseases related to tympanosclerosis

Clinical Features for Tympanosclerosis

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Drugs & Therapeutics for Tympanosclerosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Tympanosclerosis

Drug clinical trials:

Search ClinicalTrials for Tympanosclerosis

Search NIH Clinical Center for Tympanosclerosis

Search CenterWatch for Tympanosclerosis

Genetic Tests for Tympanosclerosis

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Anatomical Context for Tympanosclerosis

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Sources:
32MalaCards
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MalaCards organs/tissues related to Tympanosclerosis:

32
Bone

Animal Models for Tympanosclerosis or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Tympanosclerosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053779.2TLR4, BMP2
2MP:00053909.2SPP1, BMP2
3MP:00020068.5SPP1, TLR4, CALCA
4MP:00053858.0SPP1, BMP2, TLR4, CALCA
5MP:00036317.7SPP1, BMP2, TLR4, CALCA

Publications for Tympanosclerosis

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Sources:
50PubMed
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Articles related to Tympanosclerosis:

(show top 50)    (show all 128)
idTitleAuthorsYear
1
Could Helicobacter pylori play a role in the aetiopathogenesis of tympanosclerosis? (21888743)
2011
2
Tympanosclerosis and our surgical results. (19771442)
2010
3
Clinical analysis of intratympanic tympanosclerosis: etiology, ossicular chain findings, and hearing results of surgery. (19685361)
2010
4
Does exogenous nitric oxide influence tympanosclerosis? An experimental study. (18945497)
2008
5
Evaluation of plasma fibronectine level as a probable indicator for tympanosclerosis. (17470306)
2008
6
Stapedectomy in tympanosclerosis, hearing results. (18454228)
2008
7
Management of tympanosclerosis with ossicular fixation: review and presentation of long-term results of 30 new cases. (17963670)
2007
8
Malleostapedotomy in tympanosclerosis patients. (17524174)
2007
9
Comparison of free radicals and antioxidant enzymes in chronic otitis media with and without tympanosclerosis. (14710000)
2004
10
Is carotid stenosis correlated with tympanosclerosis. (15507892)
2004
11
Long-term ventilating tube with tympanosclerosis. (12610892)
2003
12
Asymptomatic tympanosclerosis. (11816394)
2002
13
Dry central perforation with tympanosclerosis and cholesteatoma. (12199160)
2002
14
Sex distribution in children with tympanosclerosis after insertion of a tympanostomy tube. (11271428)
2001
15
Macrophages and possible osteoclast differentiation in the rat bullar bone during experimental acute otitis media, with reference to tympanosclerosis. (11698794)
2001
16
Tympanosclerosis (cosmetic). (11605562)
2001
17
Tympanosclerosis: review of literature and incidence among patients with middle-ear infection. (10767919)
1999
18
Surgery of tympanosclerosis. (9425477)
1997
19
Tympanosclerosis-how we look at it. (23119284)
1997
20
Attic cholesteatoma and tympanosclerosis. (9210800)
1997
21
Attic cholesteatoma and extensive tympanosclerosis. (9397621)
1997
22
Tympanosclerosis and mini grommets: the relevance of grommet design. (7499941)
1995
23
Dry central tympanic membrane perforation and tympanosclerosis. (8313857)
1993
24
The mini-grommet and tympanosclerosis: results at two years. (8496640)
1993
25
Pathogenesis of tympanosclerosis. (8414556)
1993
26
The mini-grommet and tympanosclerosis. (2019798)
1991
27
Intra-tympanic membrane bleeding after grommet insertion and tympanosclerosis. (2394020)
1990
28
Aspiration of middle ear effusions prior to grommet insertion an etiological factor in tympanosclerosis. (2769837)
1989
29
Hearing loss in tympanosclerosis caused by grommets. (2751852)
1989
30
Temporal bone histopathology: residents' quiz. Tympanosclerosis. (2817252)
1989
31
Tympanosclerosis, grommets and shear stresses. (3243014)
1988
32
Stapedectomy in tympanosclerosis. A report of 67 cases. (3591919)
1987
33
Preservation of cochlear function in the surgery of cholesteatomatous labyrinthine fistulas and oval window tympanosclerosis. (3120083)
1987
34
Experimental tympanosclerosis following infection with Streptococcus pyogenes and vitamin D3 intoxication. (3028346)
1986
35
Type II collagen induced tympanosclerosis model in guinea pigs. (3835907)
1985
36
Tympanosclerosis of the ear drum in children. (6541211)
1984
37
Tympanosclerosis: clinical implications of the theory of pathogenesis. (6660756)
1983
38
Metaplasic bone tissue in tympanosclerosis. (6880665)
1983
39
Tympanosclerosis of the drum in secretory otitis after insertion of grommets. A prospective, comparative study. (6683295)
1983
40
Initiation and stages of mineralization in tympanosclerosis. (6255048)
1980
41
Surgical treatment of tympanosclerosis. (703456)
1978
42
Tympanosclerosis. (916775)
1977
43
President's address. Tympanosclerosis. (1265007)
1976
44
Tympanosclerosis. (4687166)
1973
45
Tympanosclerosis. (4636824)
1972
46
Tympanosclerosis. (4996152)
1971
47
Relation of otitis media chronica secretorica to tympanosclerosis. (5261124)
1969
48
Tympanosclerosis. (5782678)
1969
49
TYMPANOSCLEROSIS. (14059349)
1963
50
Tympanosclerosis. (13964950)
1963

Genetic Variations for Tympanosclerosis

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Expression for genes affiliated with Tympanosclerosis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Tympanosclerosis

Search GEO for disease gene expression data for Tympanosclerosis.

Pathways for genes affiliated with Tympanosclerosis

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Sources:
37NCBI BioSystems Database, 12EMD Millipore
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Pathways related to Tympanosclerosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1SPP1, BMP2
2
Transcription Role of VDR in regulation of genes involved in osteoporosis
Hide members
9.1SPP1, CALCA

Compounds for genes affiliated with Tympanosclerosis

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 28IUPHAR, 24HMDB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Tympanosclerosis according to GeneCards/GeneDecks:

(show all 45)
idCompoundScoreTop Affiliating Genes
1zoledronic acid449.8CALCA, BMP2
2alendronate44 49 1111.8BMP2, CALCA
3raloxifene44 28 49 1112.8BMP2, CALCA
4fibroin449.6SPP1, BMP2
5methylmethacrylate449.6BMP2, SPP1
6alizarin449.5SPP1, BMP2
7chitosan449.5SPP1, BMP2
8titanium449.5SPP1, BMP2
9atorvastatin44 49 28 11 2413.5BMP2, TLR4
10alginate449.5BMP2, SPP1
11ibmx44 28 5911.5BMP2, CALCA
1225-hydroxyvitamin d449.5SPP1, CALCA
13phosphorus449.5SPP1, CALCA
14creatinine449.5SPP1, BMP2
15fluoride449.5CALCA, SPP1
16hydroxyapatite449.4SPP1, BMP2
17neomycin449.4SPP1, BMP2
18polyethylene glycol449.4BMP2, SPP1
19infliximab44 49 1111.4SPP1, TLR4
20simvastatin44 49 59 28 11 2414.3BMP2, TLR4
21nifedipine44 49 28 1112.3SPP1, BMP2
22latex449.3SPP1, TLR4
23nitric oxide44 11 2411.0BMP2, TLR4, CALCA
241,25 dihydroxy vitamin d3449.0SPP1, BMP2, CALCA
25indomethacin44 59 28 1112.0CALCA, BMP2, SPP1
26testosterone44 59 11 2411.9CALCA, BMP2, SPP1
27tgf beta1448.9TLR4, BMP2, SPP1
28tacrolimus44 49 1110.9SPP1, BMP2, TLR4
29sb 20358044 599.9SPP1, BMP2, TLR4
30wortmannin448.9TLR4, BMP2, SPP1
31actinomycin d448.9SPP1, BMP2, TLR4
32genistein44 28 59 2 11 2413.9SPP1, BMP2, TLR4
33cholesterol44 28 11 2411.8TLR4, BMP2, SPP1
34dexamethasone44 49 28 1111.8SPP1, BMP2, TLR4
35estrogen448.7CALCA, BMP2, SPP1
36alanine448.7TLR4, BMP2, SPP1
37retinoic acid44 249.5SPP1, BMP2, TLR4
38calcitriol44 59 11 2411.4SPP1, BMP2, TLR4, CALCA
39vitamin d448.4CALCA, TLR4, BMP2, SPP1
40cyclosporin a44 28 5910.4SPP1, BMP2, TLR4, CALCA
41lactate448.4CALCA, TLR4, BMP2, SPP1
42cysteine448.4TLR4, BMP2, SPP1
43vegf448.4SPP1, BMP2, TLR4, CALCA
44calcium44 49 11 2411.3SPP1, BMP2, TLR4, CALCA
45glucose448.2SPP1, BMP2, TLR4

GO Terms for genes affiliated with Tympanosclerosis

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Sources:
16Gene Ontology
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Cellular components related to Tympanosclerosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.6SPP1, BMP2, CALCA

Biological processes related to Tympanosclerosis according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of ossificationGO:0457789.6BMP2, CALCA
2negative regulation of osteoclast differentiationGO:0456719.5TLR4, CALCA
3positive regulation of interleukin-8 productionGO:0327579.4TLR4, CALCA
4positive regulation of ERK1 and ERK2 cascadeGO:0703749.3BMP2, TLR4
5embryo implantationGO:0075669.1SPP1, CALCA
6activation of MAPK activityGO:0001879.0BMP2, TLR4
7osteoblast differentiationGO:0016499.0SPP1, BMP2
8inflammatory responseGO:0069548.7CALCA, BMP2, SPP1

Products for genes affiliated with Tympanosclerosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Tympanosclerosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet