MCID: TYM001
MIFTS: 30

Tympanosclerosis malady

Categories: Ear diseases

Aliases & Classifications for Tympanosclerosis

Aliases & Descriptions for Tympanosclerosis:

Name: Tympanosclerosis 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:1214
ICD9CM 35 385.09
SNOMED-CT 64 111540000
ICD10 33 H74.0
UMLS 69 C0155477

Summaries for Tympanosclerosis

MalaCards based summary : Tympanosclerosis is related to deafness, progressive, with stapes fixation and otitis media. An important gene associated with Tympanosclerosis is TLR4 (Toll Like Receptor 4), and among its related pathways/superpathways are NF-KappaB Family Pathway and Rheumatoid arthritis. Affiliated tissues include bone.

Wikipedia : 71 Tympanosclerosis (also known as myringosclerosis or intratympanic tympanosclerosis) is a condition... more...

Related Diseases for Tympanosclerosis

Diseases related to Tympanosclerosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 58)
id Related Disease Score Top Affiliating Genes
1 deafness, progressive, with stapes fixation 10.8
2 otitis media 10.2
3 spondylometaphyseal dysplasia east-african type 10.2 TLR4 TNF
4 spotted fever 10.2 TLR4 TNF
5 aortic coarctation 10.2 TLR4 TNF
6 parkinson disease 11 10.2 TLR4 TNF
7 aseptic meningitis 10.2 TLR4 TNF
8 hypoparathyroidism-retardation-dysmorphism syndrome 10.2 TLR4 TNF
9 parasitic ichthyosporea infectious disease 10.2 TLR4 TNF
10 mikulicz disease 10.2 TLR4 TNF
11 rheumatoid factor-negative juvenile idiopathic arthritis without anti-nuclear antibodies 10.2 TLR4 TNF
12 rickettsialpox 10.2 TLR4 TNF
13 autosomal recessive type iv ehlers-danlos syndrome 10.2 TLR4 TNF
14 neuropathy 10.2 TLR4 TNF
15 crohn's colitis 10.2 TLR4 TNF
16 abnormal retinal correspondence 10.2 TLR4 TNF
17 inappropriate adh syndrome 10.2 TLR4 TNF
18 ovarian cystic teratoma 10.1 TLR4 TNF
19 dentin caries 10.1 TLR4 TNF
20 pericholangitis 10.1 TLR4 TNF
21 immunoglobulin g deficiency 10.1 TLR4 TNF
22 myiasis 10.1 TLR4 TNF
23 blepharochalasis 10.1 TLR4 TNF
24 choroiditis 10.1 TLR4 TNF
25 rift valley fever 10.1 TLR4 TNF
26 mansonelliasis 10.1 TLR4 TNF
27 mucopolysaccharidosis 10.1 SOD2 TNF
28 infancy electroclinical syndrome 10.1 TLR4 TNF
29 unilateral hypoactive labyrinth 10.1 TLR4 TNF
30 dengue hemorrhagic fever 10.1 TLR4 TNF
31 dentin dysplasia 10.1 BMP2 CALCA
32 tetanus 10.1 CALCA TNF
33 classic type lipoma 10.1 BMP2 TNF
34 benign eccrine breast spiradenoma 10.1 TLR4 TNF
35 liver inflammatory pseudotumor 10.1 TLR4 TNF
36 central nervous system lymphoma 10.1 CALCA TNF
37 infantile hypotonia 10.1 CALCA TNF
38 hallucinogen dependence 10.1 TLR4 TNF
39 dysbaric osteonecrosis 10.1 BMP2 CALCA
40 conjunctival concretion 10.0 SOD2 TNF
41 keratomalacia 10.0 TLR4 TNF
42 ischemic bone disease 10.0 BMP2 CALCA
43 neovascular glaucoma 10.0 TLR4 TNF
44 cholesteatoma 10.0
45 optic nerve hypoplasia 10.0 TLR4 TNF
46 pulmonary tuberculosis 10.0 TLR4 TNF
47 necrobiosis lipoidica 10.0 SOD2 TNF
48 atherosclerosis 9.9
49 senile reticular retinal degeneration 9.9 CALCA SOD2 TNF
50 nephropathy with pretibial epidermolysis bullosa and deafness 9.9 TLR4 TNF

Graphical network of the top 20 diseases related to Tympanosclerosis:



Diseases related to Tympanosclerosis

Symptoms & Phenotypes for Tympanosclerosis

Drugs & Therapeutics for Tympanosclerosis

Interventional clinical trials:


id Name Status NCT ID Phase
1 Gas Supply, Demand and Middle Ear Gas Balance: Specific Aim 3c Completed NCT00422851

Search NIH Clinical Center for Tympanosclerosis

Genetic Tests for Tympanosclerosis

Anatomical Context for Tympanosclerosis

MalaCards organs/tissues related to Tympanosclerosis:

39
Bone

Publications for Tympanosclerosis

Articles related to Tympanosclerosis:

(show top 50) (show all 145)
id Title Authors Year
1
The effect of melatonin and vitamin C treatment on the experimentally induced tympanosclerosis: study in rats. ( 27484331 )
2016
2
Neuroglial Choristoma of the Middle Ear with Massive Tympanosclerosis: A Case Report and Literature Review. ( 27942605 )
2016
3
Genetic polymorphisms affecting antioxidant enzymes are present in tympanosclerosis patients. ( 27534583 )
2016
4
Tympanosclerosis Presenting as Mass: Workup and Differential. ( 27656306 )
2016
5
Ectopic Mineralization and Conductive Hearing Loss in Enpp1asj Mutant Mice, a New Model for Otitis Media and Tympanosclerosis. ( 27959908 )
2016
6
Efficacy of pre-operative computed tomography evaluation of the tympanic cavity for hearing improvement after stapes surgery for tympanosclerosis with stapes fixation. ( 25706157 )
2015
7
Manubrio-stapedioplasty: new surgical technique for malleus and incus fixation due to tympanosclerosis. ( 25883094 )
2015
8
Increased carotid artery intima-media thickness in patients with tympanosclerosis: Common risk factors with atherosclerosis? ( 25835276 )
2015
9
Role of Chlamydia pneumoniae and Helicobacteria pylori in the development of tympanosclerosis. ( 25956614 )
2015
10
Does systemic clarithromycin therapy have an inhibitory effect on tympanosclerosis? An experimental animal study. ( 25619629 )
2015
11
Correlation Between Tympanosclerosis and Helicobacter pylori. ( 26568799 )
2015
12
An Analysis of Surgical Treatment Results of Patients With Tympanosclerosis. ( 26517462 )
2015
13
Immunohistochemical investigation of inducible nitric oxide synthase, osteopontin, and calcium-sensing receptor in a myringosclerosis/tympanosclerosis model. ( 24136309 )
2014
14
Combining Use of Captopril and Losartan Attenuates the Progress of Streptococcus pneumoniae-Induced Tympanosclerosis through the Suppression of TGF-I^1 Expression. ( 25360706 )
2014
15
PAI-1 inhibits development of chronic otitis media and tympanosclerosis in a mouse model of otitis media. ( 25399881 )
2014
16
Surgery of isolated malleus fixation due to tympanosclerosis. ( 25503358 )
2014
17
The effect of stapes fixation on hearing results in tympanosclerosis treated by mobilization. ( 25472817 )
2014
18
Morphological Alterations in the Tympanic Membrane Affected by Tympanosclerosis: Ultrastructural Study. ( 24134073 )
2013
19
Experience with the Vibrant Soundbridge RW-Coupler for round window Vibroplasty with tympanosclerosis. ( 22385350 )
2012
20
Expressions of TGF-I^1 and MMP-9 in a guinea pig model of tympanosclerosis: possible role in the pathogenesis of this disorder. ( 22777961 )
2012
21
[Assessment of Tumor Necrosis Factor alpha gene expression profile in selected structures of middle ear in patients with tympanosclerosis]. ( 23164102 )
2012
22
Could Helicobacter pylori play a role in the aetiopathogenesis of tympanosclerosis? ( 21888743 )
2011
23
Serum matrix metalloproteinases and tympanosclerosis. ( 20955636 )
2011
24
Evaluation of the polymorphism in the Toll-like receptor 4 (TLR4) genes of tympanosclerosis patients. ( 19398177 )
2010
25
Clinical analysis of intratympanic tympanosclerosis: etiology, ossicular chain findings, and hearing results of surgery. ( 19685361 )
2010
26
Is there any relation between coronary atherosclerosis and tympanosclerosis? ( 20382609 )
2010
27
Tympanosclerosis and our surgical results. ( 19771442 )
2010
28
[Expression and localization of macrophages and BMP2 in mucosa of tympanosclerosis]. ( 19670606 )
2009
29
A computational method for the semi-automated quantitative analysis of tympanic membrane perforations and tympanosclerosis. ( 19643399 )
2009
30
Hearing results of surgery for tympanosclerosis. ( 18704475 )
2009
31
The effect of stapes mobility on hearing outcome and which procedure to choose in fixed stapes in children tympanosclerosis. ( 18394718 )
2008
32
Evaluation of plasma fibronectine level as a probable indicator for tympanosclerosis. ( 17470306 )
2008
33
Analysis of long-term hearing after tympanosclerosis with total/partial stapedectomy and prosthesis used. ( 18607937 )
2008
34
Stapedectomy in tympanosclerosis, hearing results. ( 18454228 )
2008
35
The effect of topical doxycycline in the prevention of experimental tympanosclerosis. ( 18388770 )
2008
36
Topical application of calcium channel blockers to reduce the progression of experimentally induced myringosclerosis and tympanosclerosis. ( 18176349 )
2008
37
Does exogenous nitric oxide influence tympanosclerosis? An experimental study. ( 18945497 )
2008
38
Management of tympanosclerosis with ossicular fixation: review and presentation of long-term results of 30 new cases. ( 17963670 )
2007
39
Malleostapedotomy in tympanosclerosis patients. ( 17524174 )
2007
40
Influence of hypercalcemia in the formation of tympanosclerosis in rats. ( 16371843 )
2006
41
Tympanosclerosis revisited. ( 23120263 )
2006
42
Tympanosclerosis involving the ossicular chain: mobility of the stapes in association with hearing results. ( 16923708 )
2006
43
Is carotid stenosis correlated with tympanosclerosis. ( 15507892 )
2004
44
Possible relationship between tympanosclerosis and atherosclerosis. ( 15267174 )
2004
45
An analysis of the single-stage tympanoplasty with over-underlay grafting in tympanosclerosis. ( 15129093 )
2004
46
Comparison of free radicals and antioxidant enzymes in chronic otitis media with and without tympanosclerosis. ( 14710000 )
2004
47
Long-term ventilating tube with tympanosclerosis. ( 12610892 )
2003
48
Tympanosclerosis in the rat tympanic membrane: an experimental study. ( 12352683 )
2002
49
Possible inflammatory mediators in tympanosclerosis development. ( 11955606 )
2002
50
Dry central perforation with tympanosclerosis and cholesteatoma. ( 12199160 )
2002

Variations for Tympanosclerosis

Expression for Tympanosclerosis

Search GEO for disease gene expression data for Tympanosclerosis.

Pathways for Tympanosclerosis

GO Terms for Tympanosclerosis

Biological processes related to Tympanosclerosis according to GeneCards Suite gene sharing:

(show all 24)
id Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription, DNA-templated GO:0045892 9.79 BMP2 CALCA TNF
2 positive regulation of gene expression GO:0010628 9.75 BMP2 TLR4 TNF
3 cellular response to organic cyclic compound GO:0071407 9.61 BMP2 TNF
4 apoptotic signaling pathway GO:0097190 9.61 TLR4 TNF
5 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.61 BMP2 TLR4 TNF
6 regulation of blood pressure GO:0008217 9.6 CALCA SOD2
7 positive regulation of JNK cascade GO:0046330 9.59 TLR4 TNF
8 I-kappaB kinase/NF-kappaB signaling GO:0007249 9.58 TLR4 TNF
9 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.57 SOD2 TNF
10 positive regulation of interferon-gamma production GO:0032729 9.56 TLR4 TNF
11 negative regulation of fat cell differentiation GO:0045599 9.55 SOD2 TNF
12 positive regulation of interleukin-6 production GO:0032755 9.54 TLR4 TNF
13 lipopolysaccharide-mediated signaling pathway GO:0031663 9.52 TLR4 TNF
14 negative regulation of interleukin-6 production GO:0032715 9.51 TLR4 TNF
15 activation of MAPK activity GO:0000187 9.5 BMP2 TLR4 TNF
16 vasodilation GO:0042311 9.49 CALCA SOD2
17 negative regulation of osteoclast differentiation GO:0045671 9.48 CALCA TLR4
18 positive regulation of NF-kappaB import into nucleus GO:0042346 9.46 TLR4 TNF
19 inflammatory response GO:0006954 9.46 BMP2 CALCA TLR4 TNF
20 positive regulation of chemokine production GO:0032722 9.4 TLR4 TNF
21 positive regulation of ossification GO:0045778 9.37 BMP2 CALCA
22 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.26 TLR4 TNF
23 positive regulation of nitric oxide biosynthetic process GO:0045429 9.13 SOD2 TLR4 TNF
24 positive regulation of interleukin-8 production GO:0032757 8.8 CALCA TLR4 TNF

Sources for Tympanosclerosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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