MCID: TYM001
MIFTS: 30

Tympanosclerosis malady

Category: Ear diseases

Aliases & Classifications for Tympanosclerosis

About this section

Aliases & Descriptions for Tympanosclerosis:

Name: Tympanosclerosis 11 13 68

Classifications:



External Ids:

Disease Ontology11 DOID:1214
ICD9CM32 385.09
SNOMED-CT62 111540000
ICD1030 H74.0

Summaries for Tympanosclerosis

About this section
Wikipedia:71 Tympanosclerosis (also known as myringosclerosis or intratympanic tympanosclerosis) is a condition... more...

MalaCards based summary: Tympanosclerosis is related to deafness, progressive, with stapes fixation and otitis media. An important gene associated with Tympanosclerosis is TLR4 (Toll Like Receptor 4), and among its related pathways are IL-10 Pathway and IgA-Producing B Cells in the Intestine. Affiliated tissues include bone.

Related Diseases for Tympanosclerosis

About this section

Diseases related to Tympanosclerosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 58)
idRelated DiseaseScoreTop Affiliating Genes
1deafness, progressive, with stapes fixation10.8
2otitis media10.2
3spondylometaphyseal dysplasia east-african type10.2TLR4, TNF
4spotted fever10.2TLR4, TNF
5aortic coarctation10.2TLR4, TNF
6parkinson disease 1110.2TLR4, TNF
7aseptic meningitis10.2TLR4, TNF
8hypoparathyroidism-retardation-dysmorphism syndrome10.2TLR4, TNF
9parasitic ichthyosporea infectious disease10.2TLR4, TNF
10mikulicz disease10.2TLR4, TNF
11rheumatoid factor-negative juvenile idiopathic arthritis without anti-nuclear antibodies10.2TLR4, TNF
12rickettsialpox10.2TLR4, TNF
13autosomal recessive type iv ehlers-danlos syndrome10.2TLR4, TNF
14neuropathy10.2TLR4, TNF
15crohn's colitis10.2TLR4, TNF
16abnormal retinal correspondence10.2TLR4, TNF
17inappropriate adh syndrome10.2TLR4, TNF
18ovarian cystic teratoma10.1TLR4, TNF
19dentin caries10.1TLR4, TNF
20pericholangitis10.1TLR4, TNF
21immunoglobulin g deficiency10.1TLR4, TNF
22myiasis10.1TLR4, TNF
23blepharochalasis10.1TLR4, TNF
24choroiditis10.1TLR4, TNF
25rift valley fever10.1TLR4, TNF
26mansonelliasis10.1TLR4, TNF
27mucopolysaccharidosis10.1SOD2, TNF
28infancy electroclinical syndrome10.1TLR4, TNF
29unilateral hypoactive labyrinth10.1TLR4, TNF
30dengue hemorrhagic fever10.1TLR4, TNF
31dentin dysplasia10.1BMP2, CALCA
32tetanus10.1CALCA, TNF
33classic type lipoma10.1BMP2, TNF
34benign eccrine breast spiradenoma10.1TLR4, TNF
35liver inflammatory pseudotumor10.1TLR4, TNF
36central nervous system lymphoma10.1CALCA, TNF
37infantile hypotonia10.1CALCA, TNF
38hallucinogen dependence10.1TLR4, TNF
39dysbaric osteonecrosis10.1BMP2, CALCA
40conjunctival concretion10.0SOD2, TNF
41keratomalacia10.0TLR4, TNF
42ischemic bone disease10.0BMP2, CALCA
43neovascular glaucoma10.0TLR4, TNF
44cholesteatoma10.0
45optic nerve hypoplasia10.0TLR4, TNF
46pulmonary tuberculosis10.0TLR4, TNF
47necrobiosis lipoidica10.0SOD2, TNF
48atherosclerosis9.9
49senile reticular retinal degeneration9.9CALCA, SOD2, TNF
50nephropathy with pretibial epidermolysis bullosa and deafness9.9TLR4, TNF

Graphical network of the top 20 diseases related to Tympanosclerosis:



Diseases related to tympanosclerosis

Symptoms & Phenotypes for Tympanosclerosis

About this section

Drugs & Therapeutics for Tympanosclerosis

About this section

Interventional clinical trials:

idNameStatusNCT IDPhase
1Gas Supply, Demand and Middle Ear Gas Balance: Specific Aim 3cCompletedNCT00422851

Search NIH Clinical Center for Tympanosclerosis

Genetic Tests for Tympanosclerosis

About this section

Anatomical Context for Tympanosclerosis

About this section

MalaCards organs/tissues related to Tympanosclerosis:

36
Bone

Publications for Tympanosclerosis

About this section

Articles related to Tympanosclerosis:

(show top 50)    (show all 145)
idTitleAuthorsYear
1
The effect of melatonin and vitamin C treatment on the experimentally induced tympanosclerosis: study in rats. (27484331)
2016
2
Neuroglial Choristoma of the Middle Ear with Massive Tympanosclerosis: A Case Report and Literature Review. (27942605)
2016
3
Genetic polymorphisms affecting antioxidant enzymes are present in tympanosclerosis patients. (27534583)
2016
4
Tympanosclerosis Presenting as Mass: Workup and Differential. (27656306)
2016
5
Ectopic Mineralization and Conductive Hearing Loss in Enpp1asj Mutant Mice, a New Model for Otitis Media and Tympanosclerosis. (27959908)
2016
6
Efficacy of pre-operative computed tomography evaluation of the tympanic cavity for hearing improvement after stapes surgery for tympanosclerosis with stapes fixation. (25706157)
2015
7
Manubrio-stapedioplasty: new surgical technique for malleus and incus fixation due to tympanosclerosis. (25883094)
2015
8
Increased carotid artery intima-media thickness in patients with tympanosclerosis: Common risk factors with atherosclerosis? (25835276)
2015
9
Role of Chlamydia pneumoniae and Helicobacteria pylori in the development of tympanosclerosis. (25956614)
2015
10
Does systemic clarithromycin therapy have an inhibitory effect on tympanosclerosis? An experimental animal study. (25619629)
2015
11
Correlation Between Tympanosclerosis and Helicobacter pylori. (26568799)
2015
12
An Analysis of Surgical Treatment Results of Patients With Tympanosclerosis. (26517462)
2015
13
Immunohistochemical investigation of inducible nitric oxide synthase, osteopontin, and calcium-sensing receptor in a myringosclerosis/tympanosclerosis model. (24136309)
2014
14
Combining Use of Captopril and Losartan Attenuates the Progress of Streptococcus pneumoniae-Induced Tympanosclerosis through the Suppression of TGF-I^1 Expression. (25360706)
2014
15
PAI-1 inhibits development of chronic otitis media and tympanosclerosis in a mouse model of otitis media. (25399881)
2014
16
Surgery of isolated malleus fixation due to tympanosclerosis. (25503358)
2014
17
The effect of stapes fixation on hearing results in tympanosclerosis treated by mobilization. (25472817)
2014
18
Morphological Alterations in the Tympanic Membrane Affected by Tympanosclerosis: Ultrastructural Study. (24134073)
2013
19
Experience with the Vibrant Soundbridge RW-Coupler for round window Vibroplasty with tympanosclerosis. (22385350)
2012
20
Expressions of TGF-I^1 and MMP-9 in a guinea pig model of tympanosclerosis: possible role in the pathogenesis of this disorder. (22777961)
2012
21
Assessment of Tumor Necrosis Factor alpha gene expression profile in selected structures of middle ear in patients with tympanosclerosis]. (23164102)
2012
22
Could Helicobacter pylori play a role in the aetiopathogenesis of tympanosclerosis? (21888743)
2011
23
Serum matrix metalloproteinases and tympanosclerosis. (20955636)
2011
24
Evaluation of the polymorphism in the Toll-like receptor 4 (TLR4) genes of tympanosclerosis patients. (19398177)
2010
25
Clinical analysis of intratympanic tympanosclerosis: etiology, ossicular chain findings, and hearing results of surgery. (19685361)
2010
26
Is there any relation between coronary atherosclerosis and tympanosclerosis? (20382609)
2010
27
Tympanosclerosis and our surgical results. (19771442)
2010
28
Expression and localization of macrophages and BMP2 in mucosa of tympanosclerosis]. (19670606)
2009
29
A computational method for the semi-automated quantitative analysis of tympanic membrane perforations and tympanosclerosis. (19643399)
2009
30
Hearing results of surgery for tympanosclerosis. (18704475)
2009
31
The effect of stapes mobility on hearing outcome and which procedure to choose in fixed stapes in children tympanosclerosis. (18394718)
2008
32
Evaluation of plasma fibronectine level as a probable indicator for tympanosclerosis. (17470306)
2008
33
Analysis of long-term hearing after tympanosclerosis with total/partial stapedectomy and prosthesis used. (18607937)
2008
34
Stapedectomy in tympanosclerosis, hearing results. (18454228)
2008
35
The effect of topical doxycycline in the prevention of experimental tympanosclerosis. (18388770)
2008
36
Topical application of calcium channel blockers to reduce the progression of experimentally induced myringosclerosis and tympanosclerosis. (18176349)
2008
37
Does exogenous nitric oxide influence tympanosclerosis? An experimental study. (18945497)
2008
38
Management of tympanosclerosis with ossicular fixation: review and presentation of long-term results of 30 new cases. (17963670)
2007
39
Malleostapedotomy in tympanosclerosis patients. (17524174)
2007
40
Influence of hypercalcemia in the formation of tympanosclerosis in rats. (16371843)
2006
41
Tympanosclerosis revisited. (23120263)
2006
42
Tympanosclerosis involving the ossicular chain: mobility of the stapes in association with hearing results. (16923708)
2006
43
Is carotid stenosis correlated with tympanosclerosis. (15507892)
2004
44
Possible relationship between tympanosclerosis and atherosclerosis. (15267174)
2004
45
An analysis of the single-stage tympanoplasty with over-underlay grafting in tympanosclerosis. (15129093)
2004
46
Comparison of free radicals and antioxidant enzymes in chronic otitis media with and without tympanosclerosis. (14710000)
2004
47
Long-term ventilating tube with tympanosclerosis. (12610892)
2003
48
Tympanosclerosis in the rat tympanic membrane: an experimental study. (12352683)
2002
49
Possible inflammatory mediators in tympanosclerosis development. (11955606)
2002
50
Dry central perforation with tympanosclerosis and cholesteatoma. (12199160)
2002

Variations for Tympanosclerosis

About this section

Expression for genes affiliated with Tympanosclerosis

About this section
Search GEO for disease gene expression data for Tympanosclerosis.

Pathways for genes affiliated with Tympanosclerosis

About this section

GO Terms for genes affiliated with Tympanosclerosis

About this section

Biological processes related to Tympanosclerosis according to GeneCards Suite gene sharing:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1apoptotic signaling pathwayGO:009719010.3TLR4, TNF
2I-kappaB kinase/NF-kappaB signalingGO:000724910.3TLR4, TNF
3lipopolysaccharide-mediated signaling pathwayGO:003166310.3TLR4, TNF
4negative regulation of interleukin-6 productionGO:003271510.3TLR4, TNF
5cellular response to organic cyclic compoundGO:007140710.2BMP2, TNF
6positive regulation of chemokine productionGO:003272210.2TLR4, TNF
7positive regulation of interferon-gamma productionGO:003272910.2TLR4, TNF
8negative regulation of osteoclast differentiationGO:004567110.2CALCA, TLR4
9intrinsic apoptotic signaling pathway in response to DNA damageGO:000863010.2SOD2, TNF
10negative regulation of fat cell differentiationGO:004559910.2SOD2, TNF
11positive regulation of interleukin-6 productionGO:003275510.2TLR4, TNF
12positive regulation of interleukin-8 biosynthetic processGO:004541610.2TLR4, TNF
13positive regulation of JNK cascadeGO:004633010.1TLR4, TNF
14positive regulation of NF-kappaB import into nucleusGO:004234610.1TLR4, TNF
15positive regulation of ossificationGO:00457789.9BMP2, CALCA
16activation of MAPK activityGO:00001879.8BMP2, TLR4, TNF
17positive regulation of ERK1 and ERK2 cascadeGO:00703749.8BMP2, TLR4, TNF
18positive regulation of gene expressionGO:00106289.7BMP2, TLR4, TNF
19regulation of blood pressureGO:00082179.7CALCA, SOD2
20negative regulation of transcription, DNA-templatedGO:00458929.6BMP2, CALCA, TNF
21positive regulation of nitric oxide biosynthetic processGO:00454299.6SOD2, TLR4, TNF
22positive regulation of interleukin-8 productionGO:00327579.5CALCA, TLR4, TNF
23vasodilationGO:00423119.3CALCA, SOD2
24inflammatory responseGO:00069549.2BMP2, CALCA, TLR4, TNF

Sources for Tympanosclerosis

About this section
2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet