JOD
MCID: TYP008
MIFTS: 96

Type 1 Diabetes Mellitus (JOD) malady

Genetic diseases, Rare diseases, Endocrine diseases, Metabolic diseases categories
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Summaries for Type 1 Diabetes Mellitus

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NIH Rare Diseases:42 Diabetes mellitus type 1 (dm1) is a condition in which cells in the pancreas (beta cells) stop producing insulin, causing abnormally high blood sugar levels. lack of insulin results in the inability of the body to use glucose for energy and control the amount of sugar in the blood. dm1 can occur at any age, but usually develops by early adulthood, most often in adolescence. symptoms of high blood sugar may include frequent urination, excessive thirst, fatigue, blurred vision, tingling or loss of feeling in the hands and feet, and weight loss. the exact cause of dm1 is unknown, but having certain "variants" of specific genes may increase a person's risk to develop the condition. a predisposition to develop dm1 runs in families, but no known inheritance pattern exists. treatment includes blood sugar control and insulin replacement therapy. improper control can cause recurrence of high blood sugar, or abnormally low blood sugar (hypoglycemia) during exercise or when eating is delayed. if not treated, the condition can be life-threatening. over many years, chronic high blood sugar may be associated with a variety of complications that affect many parts of the body. last updated: 4/25/2014

MalaCards based summary: Type 1 Diabetes Mellitus, also known as diabetes mellitus, insulin-dependent, is related to diabetes mellitus and celiac disease, and has symptoms including An important gene associated with Type 1 Diabetes Mellitus is IDDM2 (insulin-dependent diabetes mellitus 2), and among its related pathways are Selected targets of HNF1 and Cell adhesion molecules (CAMs). The drugs insulin and insulin, aspart, human and the compounds liraglutide and exenatide have been mentioned in the context of this disorder. Affiliated tissues include pancreas, kidney and eye, and related mouse phenotypes are liver/biliary system and renal/urinary system.

Disease Ontology:8 A diabetes mellitus that results from the body's failure to produce insulin and has material basis in autoimmune destruction of insulin-producing beta cells of the pancreas.

Genetics Home Reference:21 Type 1 diabetes is a disorder characterized by abnormally high blood sugar levels. In this form of diabetes, specialized cells in the pancreas called beta cells stop producing insulin. Insulin controls how much glucose (a type of sugar) is passed from the blood into cells for conversion to energy. Lack of insulin results in the inability to use glucose for energy or to control the amount of sugar in the blood.

MedlinePlus:33 Diabetes means your blood glucose, or blood sugar, levels are too high. with type 1 diabetes, your pancreas does not make insulin. insulin is a hormone that helps glucose get into your cells to give them energy. without insulin, too much glucose stays in your blood. over time, high blood glucose can lead to serious problems with your heart, eyes, kidneys, nerves, and gums and teeth. type 1 diabetes happens most often in children and young adults but can appear at any age. symptoms may include being very thirsty urinating often feeling very hungry or tired losing weight without trying having sores that heal slowly having dry, itchy skin losing the feeling in your feet or having tingling in your feet having blurry eyesight a blood test can show if you have diabetes. if you do, you will need to take insulin for the rest of your life. nih: national institute of diabetes and digestive and kidney diseases

Wikipedia:65 Diabetes mellitus type more...

Descriptions from OMIM:46 222100,601388,125852

Aliases & Classifications for Type 1 Diabetes Mellitus

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Type 1 Diabetes Mellitus, Aliases & Descriptions:

Name: Type 1 Diabetes Mellitus 30 8 21
Diabetes Mellitus, Insulin-Dependent 21 46 62
Insulin-Dependent Diabetes Mellitus 8 42 21
Diabetes Mellitus, Type 1 21 46 62
Type 1 Diabetes 42 22 21
Iddm 8 42 21
Diabetes Mellitus Type 1 42 21
Juvenile-Onset Diabetes 42 21
Diabetes Mellitus, Insulin-Dependent, Susceptibility to 9
Diabetes Mellitus, Insulin Dependent 42
Diabetes Mellitus Insulin-Dependent 44
 
Juvenile-Onset Diabetes Mellitus 21
Diabetes Mellitus, Type I 46
Type I Diabetes Mellitus 8
Diabetes, Autoimmune 62
Autoimmune Diabetes 21
Diabetes Autoimmune 44
Juvenile Diabetes 21
Diabetes, Type 1 46
Diabetes Type 1 33
Jod 21
T1d 21


Classifications:



External Ids:

Disease Ontology8 DOID:9744
MeSH34 D003922
OMIM46 222100
NCIt39 C2986

Related Diseases for Type 1 Diabetes Mellitus

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Diseases in the Type 1 Diabetes Mellitus family:

Diabetes Mellitus Type 2 Diabetes Mellitus

Diseases related to Type 1 Diabetes Mellitus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 430)
idRelated DiseaseScoreTop Affiliating Genes
1diabetes mellitus32.2HLA-DQA1, HNF1A, FOXP3, HLA-DQB1, CTLA4, GAD1
2celiac disease32.1HLA-DQA1, HLA-DQB1
3diabetic ketoacidosis31.9GAD1, CTLA4, INS
4hypoglycemia31.9INS, GAD1, IAPP
5thyroiditis31.8CTLA4, PTPN22
6autonomic neuropathy31.7GAD1, INS
7autoimmune thyroiditis31.7GAD1, PTPN22, CTLA4
8graves' disease31.5PTPN22, HLA-DQA1, HLA-DQB1, GAD1, CTLA4
9glucose intolerance31.5INS, PAX4, IAPP
10hyperglycemia31.4HNF1A, IAPP, PAX4, INS, GAD1
11insulin resistance31.4PAX4, INS, IAPP, HNF1A
12diabetic neuropathy31.3GAD1, INS
13hyperinsulinism31.3IAPP, PAX4, INS
14stiff-person syndrome31.2GAD1
15gestational diabetes31.2GAD1, HNF1A, IAPP, INS
16insulinoma31.1HNF1A, IAPP, PAX4, INS, GAD1
17maturity-onset diabetes of the young31.1INS, PAX4, HNF1A
18type 2 diabetes mellitus31.1GAD1, HNF1A, IAPP, INS, IDDM2, PAX4
19hepatitis b30.9HNF1A, HLA-DQA1, HLA-DQB1
20systemic lupus erythematosus30.8HLA-DQA1, OAS1, PTPN22, CTLA4, HLA-DQB1
21hyperthyroidism30.8CTLA4, PTPN22, INS
22systemic scleroderma30.7CTLA4, PTPN22, HLA-DQB1
23permanent neonatal diabetes mellitus30.7INS
24multiple sclerosis30.7CTLA4, GAD1, FOXP3, PTPN22, HLA-DQB1, HLA-DQA1
25inflammatory bowel disease30.5HLA-DQB1, PTPN22, FOXP3, CTLA4
26juvenile rheumatoid arthritis30.4HLA-DQB1, HLA-DQA1
27lymphopenia30.2IDDM2, PTPN22, FOXP3
28endotheliitis10.9
29diabetic nephropathy10.9
30pancreatitis10.8
31neuropathy10.8
32artery disease10.8
33obesity10.7
34periodontitis10.7
35diabetic retinopathy10.6
36hepatitis10.6
37polyneuropathy10.6
38histiocytosis-lymphadenopathy plus syndrome10.6
39atherosclerosis10.6
40diabetic polyneuropathy10.6
41prediabetes syndrome10.5GAD1, INS
42diabetes mellitus, insulin-dependent, 1910.5
43hypertriglyceridemia10.5
44periodontal disease10.5
45proteinuria10.5
46retinitis10.5
47exocrine pancreatic insufficiency10.4
48hypertension10.4
49renal tubular acidosis10.4
50hepatitis c10.4

Graphical network of the top 20 diseases related to Type 1 Diabetes Mellitus:



Diseases related to type 1 diabetes mellitus

Symptoms for Type 1 Diabetes Mellitus

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Symptoms by clinical synopsis from OMIM:

125852

Clinical features from OMIM:

222100,601388,125852

HPO human phenotypes related to Type 1 Diabetes Mellitus:

(show all 9)
id Description Frequency HPO Source Accession
1 type i diabetes mellitus HP:0100651
2 polyuria HP:0000103
3 diabetes mellitus HP:0000819
4 heterogeneous HP:0001425
5 polydipsia HP:0001959
6 ketoacidosis HP:0001993
7 polyphagia HP:0002591
8 abnormality of the immune system HP:0002715
9 hyperglycemia HP:0003074

Drugs & Therapeutics for Type 1 Diabetes Mellitus

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Drug clinical trials:

Search ClinicalTrials for Type 1 Diabetes Mellitus

Search NIH Clinical Center for Type 1 Diabetes Mellitus

Inferred drug relations via UMLS62/NDF-RT40:

Show with subtypes

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Type 1 Diabetes Mellitus cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Type 1 Diabetes Mellitus:
Bone marrow-derived adult mesenchymal stem cells for treatment of type I diabetes
Dendritic cells for type I diabetes
DIABECELL
Endothelial progenitor cell and islet cotransplantation for diabetes
Hematopoietic stem cell transplantation for new-onset type 1 diabetes
Hematopoietic stem cells for early-onset type I diabetes mellitus
Hematopoietic stem cells for treatment of early-onset type I diabetes mellitus
Hematopoietic stem cells for type I diabetes mellitus
Human islet transplantation to treat diabetes
Porcine embryonic pancreatic tissue transplantation for diabetes
Prochymal
Regulatory T cells for type I diabetes
StemGenex
Umbilical cord-derived mesenchymal stem cells for treatment of type I diabetes
VC-01, embryonic stem cell-derived pancreatic progenitor cells for treatment of diabetes
Embryonic/Adult Cultured Cells Related to Type 1 Diabetes Mellitus:
Bone marrow-derived mesenchymal stem cells (family)
Mouse immunosuppressive dendritic cells, PMIDs: 17665986, 18552749, 23148758
Immunosuppressive dendritic cells, PMIDs: 17665986, 18552749, 23148758
Encapsulated neonatal porcine islets (DIABECELL, PMIDs: 15808678, 18814261, 17607741, 21358330, 21535153, 16131605, 23088180, 19063691, 16298643, 11202575, 17381690
Mouse Islets, PMID: 22362173
Umbilical cord blood-derived endothelial progenitor cells, PMID: 22362173
Pancreatic islets, PMID: 22362173
Peripheral blood-derived hematopoietic stem cells (family), PMID: 23190701
Peripheral blood-derived hematopoietic stem cells, PMID: 23190701
Peripheral blood-derived hematopoietic stem cells , PMID: 23190701
Bone marrow-derived hematopoietic stem cells (family)
Pancreatic islets (cadavers), PMIDs: 15983207, 10911004
Fetal pancreatic tissue, PMIDs: 16768546, 19433788
Regulatory T cells, PMIDs: 15322272, 16903917
Adipose-derived stem cells (StemGenex
Umbilical cord-derived mesenchymal stem cells (family)
Pancreatic endoderm/endocrine precursor-like cells, PMIDs: 18834446, 22623968, 18034635

Genetic Tests for Type 1 Diabetes Mellitus

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Genetic tests related to Type 1 Diabetes Mellitus:

id Genetic test Affiliating Genes
1 Diabetes Mellitus Type 122

Anatomical Context for Type 1 Diabetes Mellitus

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MalaCards organs/tissues related to Type 1 Diabetes Mellitus:

32
Pancreas, Kidney, Eye, Bone, Endothelial, Thyroid, Heart, Testes, Skin, T cells, Pancreatic islet, Bone marrow, Brain, Liver, Pituitary, Ovary, Cortex, Retina, Small intestine, Colon, Adipocyte, Placenta, Myeloid, Monocytes, Neutrophil, Whole blood

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Type 1 Diabetes Mellitus:
id TissueAnatomical CompartmentCell Relevance
1 BoneBone MarrowBone Marrow Stromal Cells Potential therapeutic candidate
2 PancreasIslets of LangerhansMature Beta Cells Potential therapeutic candidate, affected by disease
3 BloodCord BloodMesenchymal Stem Cells Potential therapeutic candidate
4 AdiposeSubcutaneous White AdiposeMesenchymal Stem Cells Potential therapeutic candidate
5 Umbilical CordWharton's JellyMesenchymal Stem Cells Potential therapeutic candidate
6 AdiposeSubcutaneous White AdiposeStromal Cells Potential therapeutic candidate

Animal Models for Type 1 Diabetes Mellitus or affiliated genes

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MGI Mouse Phenotypes related to Type 1 Diabetes Mellitus:

36 (show all 19)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537010.1LRP5, PTPN22, HNF1A, CTLA4, INS, HLA-DQB1
2MP:000536710.1HPS1, FOXP3, HNF1A, HLA-DQB1, INS, PTPN22
3MP:000301210.1ZBTB16, HPS1, INS, HNF1A, FOXP3, GAD1
4MP:000538110.1CTLA4, HNF1A, ITPR3, FOXP3, PTPN22, INS
5MP:000539010.0CTLA4, GAD1, HNF1A, IAPP, ZBTB16, LRP5
6MP:001077110.0HNF1A, HPS1, ITPR3, FOXP3, INS, CTLA4
7MP:000538910.0G6PC2, ZBTB16, INS, HNF1A, FOXP3, ITPR3
8MP:000538810.0HPS1, HLA-DQB1, PTPN22, FOXP3, GAD1, CTLA4
9MP:00028739.9HLA-DQB1, PAX4, CTLA4, GAD1, ITPR3, FOXP3
10MP:00053719.9HPS1, ZBTB16, LRP5, FOXP3, GAD1
11MP:00053849.9FOXP3, HLA-DQB1, HPS1, LRP5, PTPN22, INS
12MP:00053869.8GAD1, ITPR3, FOXP3, G6PC2, INS, LRP5
13MP:00053979.8HPS1, ZBTB16, LRP5, HLA-DQA1, HLA-DQB1, PTPN22
14MP:00053879.8IAPP, LRP5, CTLA4, HPS1, HLA-DQA1, HLA-DQB1
15MP:00107689.8PTPN22, FOXP3, CTLA4, ITPR3, PAX4, HPS1
16MP:00053799.7CTLA4, ZBTB16, HLA-DQB1, LRP5, INS, PTPN22
17MP:00053789.7HLA-DQB1, INS, GAD1, HNF1A, ITPR3, FOXP3
18MP:00053859.6INS, LRP5, CTLA4, HPS1, FOXP3, PTPN22
19MP:00053769.5CTLA4, ZBTB16, HNF1A, HPS1, ITPR3, FOXP3

Publications for Type 1 Diabetes Mellitus

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Articles related to Type 1 Diabetes Mellitus:

(show top 50)    (show all 1057)
idTitleAuthorsYear
1
Mutilating fingertip ulcers in uncontrolled type 1 diabetes mellitus. (23887501)
2014
2
The melanocortin system and insulin resistance in humans: insights from a patient with complete POMC deficiency and type 1 diabetes mellitus. (23649472)
2014
3
Sudden death of a 15-year-old girl due to fulminant type 1 diabetes mellitus-diabetic ketoacidosis induced cerebral edema? (25066164)
2014
4
Insulin pump: A popular device for management of type 1 diabetes mellitus. (24381902)
2013
5
HLA class II SNP interactions and the association with type 1 diabetes mellitus in Bengali speaking patients of Eastern India. (23441825)
2013
6
Periodontal disease and type 1 diabetes mellitus: associations with glycemic control and complications: an Indian perspective. (23680241)
2013
7
Prevalence of celiac disease in omani children with type 1 diabetes mellitus: a cross sectional study. (24044070)
2013
8
Effectiveness of groups for adolescents with type 1 diabetes mellitus and their parents. (23957874)
2013
9
Delayed small intestinal transit in patients with long-standing type 1 diabetes mellitus: investigation of the relationships with clinical features, gastric emptying, psychological distress, and nutritional parameters. (23126582)
2013
10
Viruses and vitamin D in the etiology of type 1 diabetes mellitus and multiple sclerosis. (22119899)
2012
11
Imaging of I^-cell mass and insulitis in insulin-dependent (Type 1) diabetes mellitus. (22889646)
2012
12
Muscle microvascular recruitment predicts insulin sensitivity in middle-aged patients with type 1 diabetes mellitus. (22167126)
2012
13
Pegylated interferon-I+2b and ribavirin combination therapy induces Hashitoxicosis followed by type 1 diabetes mellitus. (22154462)
2012
14
Prevalence of autoantibodies in children newly diagnosed with type 1 diabetes mellitus. (22558802)
2012
15
Recent incidence of type 1 diabetes mellitus in children 0-14 years in Newfoundland and Labrador, Canada climbs to over 45/100,000: a retrospective time trend study. (23146327)
2012
16
Immune intervention for type 1 diabetes mellitus. (21323814)
2011
17
Stem cell therapies for type 1 diabetes mellitus. (21702217)
2011
18
Customized cell-based treatment options to combat autoimmunity and restore beta-cell function in type 1 diabetes mellitus: current protocols and future perspectives. (20217518)
2010
19
Immunoreactivity of neuron-specific enolase (NSE) in human pancreas in health and type 1 diabetes mellitus. (21165441)
2010
20
Estimation of genetic risk for Type 1 diabetes mellitus in newborns on dried blood spot. (20101097)
2010
21
The -174GG interleukin-6 genotype is protective from retinopathy and nephropathy in juvenile onset type 1 diabetes mellitus. (19542902)
2009
22
Toward a cure for type 1 diabetes mellitus: diabetes-suppressive dendritic cells and beyond. (18540865)
2008
23
Insulin intervention in slowly progressive insulin-dependent (type 1) diabetes mellitus. (18397986)
2008
24
Heterogeneity of type 1 diabetes mellitus]. (18438531)
2008
25
Latest overview of type 1 diabetes mellitus]. (18616134)
2008
26
Young children (<5 yr) and adolescents (>12 yr) with type 1 diabetes mellitus have low rate of partial remission: diabetic ketoacidosis is an important risk factor. (18547233)
2008
27
Glycaemic control and hypoglycaemia in children, adolescents and young adults with unstable type 1 diabetes mellitus treated with insulin glargine or intermediate-acting insulin. (17550216)
2007
28
Short- and long-term glycaemic control and the state of the renin system in type 1 diabetes mellitus. (17703435)
2007
29
Radionuclide staging of renal function in type 1 diabetes mellitus. (17763163)
2007
30
Glycaemic control, markers of endothelial cell activation and oxidative stress in children with type 1 diabetes mellitus. (16442660)
2006
31
Bone mineral density and alterations of bone metabolism in children and adolescents with type 1 diabetes mellitus. (16886588)
2006
32
Serum and urinary cytokine homeostasis and renal tubular function in children with type 1 diabetes mellitus. (17252695)
2006
33
Oxidative stress and adhesion molecules in children with type 1 diabetes mellitus: a possible link. (16489975)
2006
34
Serum zinc, insulin-like growth factor-I and insulin-like growth factor binding protein-3 levels in children with type 1 diabetes mellitus. (16355814)
2005
35
Usefulness of the addition of metformin to insulin in pediatric patients with type 1 diabetes mellitus. (16091082)
2005
36
Enhanced leukocyte-platelet cross-talk in Type 1 diabetes mellitus: relationship to microangiopathy. (14717967)
2004
37
Involvement of eotaxin, eosinophils, and pancreatic predisposition in development of type 1 diabetes mellitus in the BioBreeding rat. (15557196)
2004
38
Altered distribution of the debrisoquine oxidative phenotypes in children with type 1 diabetes mellitus. (14726620)
2004
39
HLA-DQB1 alleles may influence the surface expression of DQ molecules in lymphomononuclear cells of type 1 diabetes mellitus patients. (15030582)
2004
40
Serum leptin concentrations in children with type 1 diabetes mellitus: relationship to body mass index, insulin dose, and glycemic control. (11887162)
2002
41
Cell-mediated immune responses to GAD and beta-casein in type 1 diabetes mellitus in Thailand. (11850100)
2002
42
Prognostic value of angiotensin-I converting enzyme I/D polymorphism for nephropathy in type 1 diabetes mellitus: a prospective study. (11181802)
2001
43
Beneficial effects of C-peptide on incipient nephropathy and neuropathy in patients with Type 1 diabetes mellitus. (10784221)
2000
44
Evaluation of salivary sialic acid level and Cu-Zn superoxide dismutase activity in type 1 diabetes mellitus. (11249151)
2000
45
A role of free insulin-like growth factor-I in dawn phenomenon in children and adolescents with type 1 diabetes mellitus. (10890193)
2000
46
HLA-DMA and HLA-DMB alleles in German patients with type 1 diabetes mellitus. (10519369)
1999
47
Autoimmune thyroid disease in patients with type 1 diabetes mellitus]. (9588075)
1998
48
The association between retinopathy, nephropathy, cardiovascular disease and long-term metabolic control in type 1 diabetes mellitus: a 5 year follow-up study of 442 adult patients in routine care. (9179466)
1997
49
CTLA4 alanine-17 confers genetic susceptibility to Graves' disease and to type 1 diabetes mellitus. (8989248)
1997
50
Long-term intermittent intravenous insulin therapy and type 1 diabetes mellitus. (8102666)
1993

Variations for Type 1 Diabetes Mellitus

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UniProtKB/Swiss-Prot genetic disease variations for Type 1 Diabetes Mellitus:

64
id Symbol AA change Variation ID SNP ID
1INSp.Arg55CysVAR_063732rs121908261

Clinvar genetic disease variations for Type 1 Diabetes Mellitus:

6
id Gene Name Type Significance SNP ID Assembly Location
1HNF1ANM_000545.5(HNF1A): c.608G> A (p.Arg203His)single nucleotide variantLikely pathogenicGRCh37Chr 12, 121431404: 121431404
2NM_000207.2(INS): c.163C> T (p.Arg55Cys)single nucleotide variantPathogenicrs121908261GRCh37Chr 11, 2182039: 2182039
3HNF1ANM_000545.5(HNF1A): c.872dupC (p.Gly292Argfs)duplicationPathogenicGRCh37Chr 12, 121432125: 121432125
4NM_000207.2(INS): c.94G> A (p.Gly32Ser)single nucleotide variantPathogenicrs80356664GRCh37Chr 11, 2182108: 2182108

Expression for genes affiliated with Type 1 Diabetes Mellitus

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Expression patterns in normal tissues for genes affiliated with Type 1 Diabetes Mellitus

Search GEO for disease gene expression data for Type 1 Diabetes Mellitus.

Pathways for genes affiliated with Type 1 Diabetes Mellitus

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Pathways related to Type 1 Diabetes Mellitus according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2INS, IAPP, HNF1A
210.2HLA-DQA1, CTLA4, HLA-DQB1
310.2CTLA4, HLA-DQA1, HLA-DQB1
4
Show member pathways
10.2HLA-DQA1, HLA-DQB1, FOXP3
5
Show member pathways
Immune response IL 22 signaling pathway60
G protein signaling N RAS regulation pathway60
10.2HLA-DQA1, HLA-DQB1, ITPR3
6
Show member pathways
Immune response T cell receptor signaling pathway60
Immune response CD28 signaling60
Immune response ICOS pathway in T helper cell60
10.2ITPR3, HLA-DQA1, HLA-DQB1
7
Show member pathways
10.1INS, PAX4, IAPP, HNF1A
8
Show member pathways
10.1IAPP, HNF1A, PAX4, INS
9
Show member pathways
10.1HLA-DQB1, CTLA4, HLA-DQA1, PTPN22
10
Show member pathways
10.1CTLA4, ITPR3, HLA-DQA1, HLA-DQB1
11
Show member pathways
10.1HLA-DQB1, HLA-DQA1, ITPR3, CTLA4
12
Show member pathways
10.1IAPP, INS, HLA-DQA1, HLA-DQB1
13
Show member pathways
9.9INS, GAD1, CTLA4, HLA-DQA1, HLA-DQB1, KIR2DL2
14
Show member pathways
9.9ITPR3, HLA-DQA1, KIR2DL2, CTLA4, HLA-DQB1, ZBTB16

Compounds for genes affiliated with Type 1 Diabetes Mellitus

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Compounds related to Type 1 Diabetes Mellitus according to GeneCards/GeneDecks:

(show all 21)
idCompoundScoreTop Affiliating Genes
1liraglutide44 28 1112.6IAPP, INS
2exenatide44 1111.6IAPP, INS
3sitagliptin44 1111.6INS, IAPP
4sulfonylurea4410.5IAPP, HNF1A, INS
5repaglinide50 44 1112.5PAX4, INS, IAPP
6i-app4410.5IAPP, INS
7streptozotocin4410.5INS, IAPP, GAD1
8acarbose44 1111.5IAPP, INS
9fructosamine44 2411.5INS, IAPP
10c-peptide4410.5INS, GAD1, IAPP, HNF1A
11pramlintide44 1111.4IAPP, INS
12incretin4410.4IAPP, INS
13cholesterol44 28 24 1113.3LRP5, INS, IAPP, HNF1A, CTLA4, GAD1
14oligonucleotide4410.2HNF1A, HLA-DQB1, HLA-DQA1, IAPP, GAD1
15miglitol61 44 1112.2IAPP, INS
16tyrosine4410.1ZBTB16, HLA-DQB1, INS, PTPN22, HNF1A, GAD1
17arginine4410.1HLA-DQA1, INS, IAPP, PTPN22, GAD1
18glucose4410.1HNF1A, GAD1, CTLA4, IAPP, PAX4, G6PC2
19aspartate4410.1HLA-DQB1, HLA-DQA1, ITPR3, GAD1
20glutamate4410.1PTPN22, GAD1, INS, HLA-DQB1, CTLA4
21creatinine449.8HNF1A, INS, IAPP, GAD1

GO Terms for genes affiliated with Type 1 Diabetes Mellitus

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Cellular components related to Type 1 Diabetes Mellitus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class II protein complexGO:04261310.3HLA-DQB1, HLA-DQA1
2integral component of lumenal side of endoplasmic reticulum membraneGO:07155610.2HLA-DQA1, HLA-DQB1
3integral component of plasma membraneGO:00588710.0ITPR3, HPS1, KIR3DS1, CTLA4, HLA-DQA1
4clathrin-coated endocytic vesicle membraneGO:03066910.0HLA-DQA1, HLA-DQB1
5plasma membraneGO:0058869.5CTLA4, ZBTB16, HLA-DQB1, HLA-DQA1, LRP5, KCNA3

Biological processes related to Type 1 Diabetes Mellitus according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of immune responseGO:05077710.5CTLA4, FOXP3
2endocrine pancreas developmentGO:03101810.5IAPP, PAX4, INS
3interferon-gamma-mediated signaling pathwayGO:06033310.4HLA-DQB1, HLA-DQA1, OAS1
4T cell costimulationGO:03129510.4CTLA4, HLA-DQA1, HLA-DQB1
5regulation of insulin secretionGO:05079610.4ITPR3, G6PC2, INS
6glucose homeostasisGO:04259310.4HNF1A, G6PC2, OAS1, INS
7T cell receptor signaling pathwayGO:05085210.4HLA-DQB1, HLA-DQA1, FOXP3
8positive regulation of mitosisGO:04584010.3LRP5, INS
9positive regulation of fat cell differentiationGO:04560010.3LRP5, ZBTB16
10positive regulation of cell differentiationGO:04559710.2INS, PAX4
11positive regulation of transcription, DNA-templatedGO:04589310.2ZBTB16, LRP5, FOXP3, HNF1A
12immune responseGO:00695510.2CTLA4, KIR3DS1, HLA-DQA1, HLA-DQB1
13negative regulation of T cell proliferationGO:04213010.0CTLA4, FOXP3

Molecular functions related to Type 1 Diabetes Mellitus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class II receptor activityGO:03239510.0HLA-DQB1, HLA-DQA1
2protein bindingGO:0055159.6ZBTB16, LRP5, INS, OAS1, PTPN22, FOXP3

Products for genes affiliated with Type 1 Diabetes Mellitus

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  • Antibodies
  • Proteins
  • Lysates

Sources for Type 1 Diabetes Mellitus

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet