IDDM
MCID: TYP008
MIFTS: 77

Type 1 Diabetes Mellitus (IDDM) malady

Summaries for Type 1 Diabetes Mellitus

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8Disease Ontology, 46OMIM, 32MalaCards
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Disease Ontology:8 A diabetes mellitus that results from the body's failure to produce insulin and has material basis in autoimmune destruction of insulin-producing beta cells of the pancreas.

MalaCards: Type 1 Diabetes Mellitus, also known as diabetes mellitus type 1, is related to diabetes mellitus and thyroiditis. An important gene associated with Type 1 Diabetes Mellitus is LRP5 (low density lipoprotein receptor-related protein 5), and among its related pathways are Allograft rejection and Allograft rejection. The drugs insulin and insulin, aspart, human and the compounds glucose and alanine have been mentioned in the context of this disorder. Affiliated tissues include endothelial, bone and thyroid, and related mouse phenotypes are normal and endocrine/exocrine gland.

Description from OMIM:46 222100

Aliases & Classifications for Type 1 Diabetes Mellitus

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8Disease Ontology, 9diseasecard, 42NIH Rare Diseases, 22GTR, 30LifeMap Discovery™, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 46OMIM
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Aliases & Descriptions:

type 1 diabetes mellitus 8 30
diabetes mellitus type 1 42 22
diabetes mellitus, insulin-dependent, susceptibility to 9
diabetes mellitus, insulin dependent 42
diabetes mellitus, insulin-dependent 60
insulin-dependent diabetes mellitus 8
type i diabetes mellitus 8
iddm 8


External Ids:

Disease Ontology8 DOID:9744
MeSH34 D003922
NCIt39 C2986
OMIM46 222100

Related Diseases for Type 1 Diabetes Mellitus

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Type 2 Diabetes Mellitus family:

type 1 diabetes mellitus Diabetes Mellitus

Diseases related to Type 1 Diabetes Mellitus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 301)
idRelated DiseaseScoreTop Affiliating Genes
1diabetes mellitus32.5PTPRN, PAX4, LRP5, INS, AKR1B1, HLA-DQA1
2thyroiditis31.3GAD2, CTLA4
3celiac disease31.2HLA-DQA1, HLA-DQB1
4diabetic retinopathy31.2GAD1, AKR1B1, INS
5hypoglycemia31.1INS, AKR1B1, GAD1, LSL
6autoimmune thyroiditis31.1CTLA4, GAD2, GAD1
7pancreatitis31.1INS
8diabetic ketoacidosis31.1LSL, CTLA4, GAD2, GAD1, INS
9diabetic neuropathy31.1GAD2, GAD1, AKR1B1, INS
10neuropathy31.1AKR1B1, INS
11type 2 diabetes mellitus31.0IDDM2, LSL, GAD2, GAD1, AKR1B1, INS
12graves' disease30.9PTPRN, HLA-DQA1, HLA-DQB1, GAD1, GAD2, CTLA4
13autonomic neuropathy30.9GAD2, GAD1, AKR1B1, INS
14obesity30.9LSL, GAD2, AKR1B1, INS
15diabetic autonomic neuropathy30.9MLNR, AKR1B1
16hyperglycemia30.9LSL, GAD2, GAD1, AKR1B1, INS, PAX4
17hepatitis30.9CTLA4
18type 1 diabetes30.8CSN2, CTLA4, GAD2, GAD1, INS, PTPRN
19dermatitis30.8CTLA4
20glucose intolerance30.7LSL, GAD1, INS
21insulinoma30.5GAD2, GAD1, INS, PAX4, PTPRN
22hypothyroidism30.5LSL, CTLA4, INS
23gastroparesis30.5MLNR, INS
24hypertension30.5INS
25addison's disease30.5CTLA4
26dermatitis herpetiformis30.5HLA-DQB1
27liver cirrhosis30.5LSL
28hyperinsulinism30.5LSL, INS, PAX4
29multiple sclerosis30.4LSL, CSN2, CTLA4, GAD1, HLA-DQB1, HLA-DQA1
30gestational diabetes30.4LSL, GAD1, INS, PTPRN
31hepatitis b30.4AKR1B1, HLA-DQA1, HLA-DQB1
32maturity-onset diabetes of the young30.4PAX4, INS
33proliferative diabetic retinopathy30.4GAD1
34polycystic ovary syndrome30.4INS, LSL
35viral hepatitis30.3HLA-DQA1
36cystic fibrosis30.3HLA-DQA1, INS
37acquired immunodeficiency syndrome30.3KIR2DL2
38rheumatoid arthritis30.2HLA-DQB1, CTLA4
39arthritis30.2CTLA4
40influenza30.2KIR2DL2
41ischemia30.2AKR1B1, GAD1, GAD2
42glomerulonephritis30.2NAGA
43asthma30.2HLA-DQA1, CTLA4
44retinal disease30.2INS, AKR1B1, GAD1
45lymphopenia29.8IDDM2
46diabetic nephropathy10.9
47periodontitis10.6
48diabetic polyneuropathy10.6
49polyneuropathy10.6
50atherosclerosis10.6

Graphical network of the top 20 diseases related to Type 1 Diabetes Mellitus:



Diseases related to type 1 diabetes mellitus

Clinical Features for Type 1 Diabetes Mellitus

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46OMIM
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Clinical features from OMIM:

222100

Drugs & Therapeutics for Type 1 Diabetes Mellitus

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Type 1 Diabetes Mellitus

Drug clinical trials:

Search ClinicalTrials for Type 1 Diabetes Mellitus

Search NIH Clinical Center for Type 1 Diabetes Mellitus

Search CenterWatch for Type 1 Diabetes Mellitus

Inferred drug relations via UMLS60/NDF-RT40:

Show with subtypes

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Type 1 Diabetes Mellitus cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Type 1 Diabetes Mellitus:
Bone marrow-derived adult mesenchymal stem cells for treatment of type I diabetes
Dendritic cells for type I diabetes
DIABECELL
Endothelial progenitor cell and islet cotransplantation for diabetes
Hematopoietic stem cell transplantation for new-onset type 1 diabetes
Hematopoietic stem cells for early-onset type I diabetes mellitus
Hematopoietic stem cells for treatment of early-onset type I diabetes mellitus
Hematopoietic stem cells for type I diabetes mellitus
Human islet transplantation to treat diabetes
Porcine embryonic pancreatic tissue transplantation for diabetes
Prochymal
Regulatory T cells for type I diabetes
StemGenex
Umbilical cord-derived mesenchymal stem cells for treatment of type I diabetes
VC-01, embryonic stem cell-derived pancreatic progenitor cells for treatment of diabetes
Embryonic/Adult Cultured Cells Related to Type 1 Diabetes Mellitus:
Bone marrow-derived mesenchymal stem cells (family)
Mouse immunosuppressive dendritic cells, PMIDs: 17665986, 18552749, 23148758
Immunosuppressive dendritic cells, PMIDs: 17665986, 18552749, 23148758
Encapsulated neonatal porcine islets (DIABECELL, PMIDs: 15808678, 18814261, 17607741, 21358330, 21535153, 16131605, 23088180, 19063691, 16298643, 11202575, 17381690
Mouse Islets, PMID: 22362173
Umbilical cord blood-derived endothelial progenitor cells, PMID: 22362173
Pancreatic islets, PMID: 22362173
Peripheral blood-derived hematopoietic stem cells (family), PMID: 23190701
Peripheral blood-derived hematopoietic stem cells, PMID: 23190701
Peripheral blood-derived hematopoietic stem cells , PMID: 23190701
Bone marrow-derived hematopoietic stem cells (family)
Pancreatic islets (cadavers), PMIDs: 15983207, 10911004
Fetal pancreatic tissue, PMIDs: 16768546, 19433788
Regulatory T cells, PMIDs: 15322272, 16903917
Adipose-derived stem cells (StemGenex
Umbilical cord-derived mesenchymal stem cells (family)
Pancreatic endoderm/endocrine precursor-like cells, PMIDs: 18834446, 22623968, 18034635

Genetic Tests for Type 1 Diabetes Mellitus

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22GTR
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Genetic tests related to Type 1 Diabetes Mellitus:

id Genetic test Affiliating Genes
1 Diabetes Mellitus Type 122

Anatomical Context for Type 1 Diabetes Mellitus

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Sources:
30LifeMap Discovery™, 32MalaCards
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MalaCards organs/tissues related to Type 1 Diabetes Mellitus:

32
Endothelial, Bone, Thyroid, Pancreas, T cells, Pancreatic islet, Heart, Kidney, Bone marrow, Testes, Skin, Brain, Pituitary, Liver, Ovary, Monocytes, B cells, Cortex, Myeloid, Retina, Placenta, Breast, Small intestine, Colon, Adipocyte, Whole blood

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Type 1 Diabetes Mellitus:
id TissueAnatomical CompartmentCell Relevance
1 BoneBone MarrowBone Marrow Stromal Cells Potential therapeutic candidate
2 PancreasIslets of LangerhansMature Beta Cells Potential therapeutic candidate, affected by disease
3 BloodCord BloodMesenchymal Stem Cells Potential therapeutic candidate
4 AdiposeSubcutaneous White AdiposeMesenchymal Stem Cells Potential therapeutic candidate
5 Umbilical CordWharton's JellyMesenchymal Stem Cells Potential therapeutic candidate
6 AdiposeSubcutaneous White AdiposeStromal Cells Potential therapeutic candidate

Animal Models for Type 1 Diabetes Mellitus or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Type 1 Diabetes Mellitus:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000287311.0PAX4, LRP5, INS, HLA-DQB1, GAD1, GAD2
2MP:000537910.3PTPRN, GAD2

Publications for Type 1 Diabetes Mellitus

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50PubMed
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Articles related to Type 1 Diabetes Mellitus:

(show top 50)    (show all 1243)
idTitleAuthorsYear
1
No Phenotypic Differences for Polycystic Ovary Syndrome (PCOS) Between Women With and Without Type 1 Diabetes Mellitus. (24243639)
2014
2
Subclinical hypothyroidism and dyslipidemia in children and adolescents with type 1 diabetes mellitus. (23384709)
2013
3
Testicular function during adolescence in boys with type 1 diabetes mellitus (T1D): absence of hypogonadism and differences in endocrine profile at the beginning and end of puberty. (24118936)
2013
4
Cell-based interventions to halt autoimmunity in type 1 diabetes mellitus. (23286940)
2013
5
A model of poorly controlled type 1 Diabetes Mellitus and its treatment with aerobic exercise training. (23522732)
2013
6
Cross-sectional and longitudinal relationships of body mass index with glycemic control in children and adolescents with type 1 diabetes mellitus. (23339757)
2013
7
Opposite regulation of hepatic breast cancer resistance protein in type 1 and 2 diabetes mellitus. (24342797)
2013
8
The impact of parental bonding on sexual distress in women with type 1 diabetes mellitus. (23088503)
2013
9
The effects of Pilates on metabolic control and physical performance in adolescents with type 1 diabetes mellitus. (22609217)
2012
10
Diabetes: Intensive glucose control in type 1 diabetes mellitus reduces risk of GFR loss. (22143332)
2012
11
Analysis of use of an automated bolus calculator reduces fear of hypoglycemia and improves confidence in dosage accuracy in type 1 diabetes mellitus patients treated with multiple daily insulin injections. (22401333)
2012
12
Intensive insulin therapy in patients with type 1 diabetes mellitus. (22575408)
2012
13
Estimation of Duration of Symptoms in Fulminant Type 1 Diabetes Mellitus Using HbA1c or Glycated Albumin. (23946681)
2012
14
Continuous glucose monitoring systems for type 1 diabetes mellitus. (22258980)
2012
15
Prevalence and impact of initial misclassification of pediatric type 1 diabetes mellitus. (23038480)
2012
16
Metabolic syndrome in type 1 diabetes mellitus. Does it have any impact on the course of pregnancy? (22204805)
2011
17
Early markers of glycaemic control in children with type 1 diabetes mellitus. (21966469)
2011
18
Clinical hurdles and possible solutions in the implementation of closed-loop control in type 1 diabetes mellitus. (22027329)
2011
19
Elevated plasma levels of apelin in children with type 1 diabetes mellitus. (20662349)
2010
20
Polymorphisms in the genes encoding TGF-beta1, TNF-alpha, and IL-6 show association with type 1 diabetes mellitus in the Slovak population. (20686866)
2010
21
Carotid intima-media thickness and its relations with the complications in patients with type 1 diabetes mellitus. (20150006)
2010
22
Specific association of type 1 diabetes mellitus with anti-cyclic citrullinated peptide-positive rheumatoid arthritis. (19248096)
2009
23
Presence of metabolic syndrome among patients with type 1 diabetes mellitus]. (19802415)
2009
24
Reducing postprandial hyperglycemia with adjuvant premeal pramlintide and postmeal insulin in children with type 1 diabetes mellitus. (19140902)
2009
25
The Arg16Gly variant of the beta2-adrenergic receptor predisposes to hypoglycemia unawareness in type 1 diabetes mellitus. (18334922)
2008
26
Adipose tissue 11-beta-Hydroxysteroid Dehydrogenase Type 1 and Hexose-6-Phosphate Dehydrogenase gene expressions are increased in patients with type 2 diabetes mellitus. (18963204)
2008
27
Adiponectin serum levels and their relationships to androgen concentrations and ovarian volume during puberty in girls with type 1 diabetes mellitus. (18547959)
2008
28
QTc interval and resting heart rate as long-term predictors of mortality in type 1 and type 2 diabetes mellitus: a 23-year follow-up. (17096116)
2007
29
Association of polymorphous markers Pro72Arg and C(-594)CC OF TP53 gene with diabetic polyneuropathy in patients with type 1 diabetes mellitus living in Moscow]. (18318116)
2007
30
PD-1 gene haplotype is associated with the development of type 1 diabetes mellitus in Japanese children. (17203303)
2007
31
Oxidative stress and adhesion molecules in children with type 1 diabetes mellitus: a possible link. (16489975)
2006
32
Pancreatic autoantibodies in Italian patients with newly diagnosed type 1 diabetes mellitus over the age of 20 years. (17143785)
2006
33
Apolipoprotein B as a long-term predictor of mortality in type 1 diabetes mellitus: a 15-year follow up. (16918825)
2006
34
MHC class I chain-related gene-A is associated with IA2 and IAA but not GAD in Swedish type 1 diabetes mellitus. (17130560)
2006
35
A novel analytical method for assessing glucose variability: using CGMS in type 1 diabetes mellitus. (17109596)
2006
36
Effect of acute hyperglycaemia on sodium handling and excretion of nitric oxide metabolites, bradykinin, and cGMP in Type 1 diabetes mellitus. (15317600)
2004
37
F2 isoprostane is already increased at the onset of type 1 diabetes mellitus: effect of glycemic control. (15334370)
2004
38
Aldehyde dehydrogenase 2 genotype in type 1 diabetes mellitus. (12706323)
2003
39
Alleles of diabetes-resistant BN rats contribute to insulin-dependent type 1 diabetes mellitus. (12657525)
2003
40
Beneficial effects of flexible insulin therapy in children and adolescents with type 1 diabetes mellitus. (14605970)
2003
41
Serum leptin concentrations in children with type 1 diabetes mellitus: relationship to body mass index, insulin dose, and glycemic control. (11887162)
2002
42
Transient neonatal diabetes mellitus, type 4, type 1 diabetes mellitus, or MODY: which disease is it, anyway? (12014522)
2002
43
Immunologic and genetic markers in insulin-dependent diabetes mellitus (type 1) in an Argentine population. (11474874)
2001
44
Autoimmune thyroid disease in Indian children with type 1 diabetes mellitus. (11308045)
2001
45
Diabetic mastopathy, complication of type 1 diabetes mellitus: report of two cases and a review of the literature. (9881244)
1998
46
Lack of association of the insulin gene region with type 1 (insulin-dependent) diabetes mellitus in Japanese subjects. (8163057)
1994
47
Long-term intermittent intravenous insulin therapy and type 1 diabetes mellitus. (8102666)
1993
48
Lipoprotein lipids and apolipoproteins (AI, AII, B, CII, CIII) in type 1 and type 2 diabetes mellitus in young Kuwaiti women. (1838064)
1991
49
Heparin released platelet factor 4 in uncomplicated type 1 diabetes mellitus. (1896971)
1991
50
Studies of atrial natriuretic peptide, diuresis and natriuresis in patients with diabetes mellitus types 1 and 2 after water immersion]. (2147481)
1990

Genetic Variations for Type 1 Diabetes Mellitus

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Expression for genes affiliated with Type 1 Diabetes Mellitus

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Type 1 Diabetes Mellitus

Search GEO for disease gene expression data for Type 1 Diabetes Mellitus.

Pathways for genes affiliated with Type 1 Diabetes Mellitus

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29KEGG, 51QIAGEN, 53Reactome, 37NCBI BioSystems Database, 12EMD Millipore
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Compounds for genes affiliated with Type 1 Diabetes Mellitus

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44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 59Tocris Bioscience, 2BitterDB, 49PharmGKB
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Compounds related to Type 1 Diabetes Mellitus according to GeneCards/GeneDecks:

(show all 26)
idCompoundScoreTop Affiliating Genes
1glucose4411.6PTPRN, LSL, CTLA4, GAD2, GAD1, AKR1B1
2alanine4411.4LSL, CTLA4, GAD2, GAD1, AKR1B1, MLNR
3cholesterol44 28 11 2414.3LSL, CTLA4, GAD2, GAD1, INS, LRP5
4c-peptide4411.2LSL, GAD2, GAD1, INS, PTPRN
5glycerol44 11 2413.2INS, NAGA, AKR1B1, CSN2, LSL
6arginine4411.2LSL, GAD1, HLA-DQA1, AKR1B1, INS, PTPRN
7cyclosporin a44 28 5913.2CTLA4, GAD2, GAD1, AKR1B1, PTPRN
8hydrogen44 2412.1LSL, CSN2, GAD2, GAD1, AKR1B1
9estrogen4411.1LSL, CSN2, CTLA4, AKR1B1, INS, LRP5
10glutamate4411.1CSN2, GAD2, GAD1, PTPRN
11taurine44 59 2413.1AKR1B1, GAD1, GAD2
12valproate4411.0LSL, GAD1, AKR1B1
13pyridoxal 5-phosphate4411.0GAD2, GAD1, AKR1B1
14streptozotocin4411.0INS, AKR1B1, GAD1
15hbig4411.0INS, AKR1B1
16levodopa44 1111.9AKR1B1, GAD1, GAD2
17cysteine sulfinic acid4410.9GAD1, GAD2
18hypotaurine59 44 2412.9GAD2, GAD1
19carbon dioxide44 2411.9LSL, GAD2, GAD1
203-Sulfinoalanine11 2411.9GAD1, GAD2
21haloperidol44 28 2 49 1114.8LSL, GAD1, AKR1B1
22sibutramine44 1111.7INS, LSL
23beta-hydroxybutyrate4410.6INS, LSL
24acipimox44 2811.6INS, LSL
25oligonucleotide4410.6CSN2, GAD2, GAD1, HLA-DQB1, HLA-DQA1
26repaglinide44 49 1112.5PAX4, INS

GO Terms for genes affiliated with Type 1 Diabetes Mellitus

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16Gene Ontology
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Cellular components related to Type 1 Diabetes Mellitus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:00588611.2CTLA4, GAD2, GAD1, HLA-DQB1, HLA-DQA1, MLNR
2integral to plasma membraneGO:00588710.6TNFSF12, CTLA4, HLA-DQA1, MLNR, KIR2DS5, PTPRN
3clathrin-sculpted gamma-aminobutyric acid transport vesicle membraneGO:06120210.6GAD1, GAD2
4MHC class II protein complexGO:04261310.6HLA-DQA1, HLA-DQB1

Biological processes related to Type 1 Diabetes Mellitus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1immune responseGO:00695510.9KIR2DS5, KIR2DS2, HLA-DQA1, HLA-DQB1, CTLA4, TNFSF12
2neurotransmitter biosynthetic processGO:04213610.6GAD1, GAD2
3glutamate decarboxylation to succinateGO:00654010.5GAD2, GAD1
4T cell costimulationGO:03129510.4HLA-DQA1, HLA-DQB1, CTLA4

Molecular functions related to Type 1 Diabetes Mellitus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glutamate decarboxylase activityGO:00435110.6GAD1, GAD2
2MHC class II receptor activityGO:03239510.6HLA-DQA1, HLA-DQB1
3aldo-keto reductase (NADP) activityGO:00403310.5MIOX, AKR1B1
4glutamate bindingGO:01659510.3GAD1, GAD2

Products for genes affiliated with Type 1 Diabetes Mellitus

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Type 1 Diabetes Mellitus

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet