IDDM
MCID: TYP008
MIFTS: 77

Type 1 Diabetes Mellitus (IDDM) malady

Summaries for Type 1 Diabetes Mellitus

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8Disease Ontology, 46OMIM, 32MalaCards
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Disease Ontology:8 A diabetes mellitus that results from the body's failure to produce insulin and has material basis in autoimmune destruction of insulin-producing beta cells of the pancreas.

MalaCards: Type 1 Diabetes Mellitus, also known as diabetes mellitus type 1, is related to diabetes mellitus and thyroiditis. An important gene associated with Type 1 Diabetes Mellitus is LRP5 (low density lipoprotein receptor-related protein 5), and among its related pathways are Allograft rejection and Allograft rejection. The drugs insulin and insulin, aspart, human and the compounds glucose and alanine have been mentioned in the context of this disorder. Affiliated tissues include endothelial, bone and thyroid, and related mouse phenotypes are normal and endocrine/exocrine gland.

Description from OMIM:46 222100

Aliases & Classifications for Type 1 Diabetes Mellitus

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8Disease Ontology, 30LifeMap Discovery™, 9diseasecard, 42NIH Rare Diseases, 22GTR, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 46OMIM
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Aliases & Descriptions:

type 1 diabetes mellitus 8 30
diabetes mellitus type 1 42 22
diabetes mellitus, insulin-dependent, susceptibility to 9
diabetes mellitus, insulin dependent 42
diabetes mellitus, insulin-dependent 60
insulin-dependent diabetes mellitus 8
type i diabetes mellitus 8
iddm 8


External Ids:

Disease Ontology8 DOID:9744
MeSH34 D003922
NCIt39 C2986
OMIM46 222100

Related Diseases for Type 1 Diabetes Mellitus

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Type 2 Diabetes Mellitus family:

type 1 diabetes mellitus Diabetes Mellitus

Diseases related to Type 1 Diabetes Mellitus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 301)
idRelated DiseaseScoreTop Affiliating Genes
1diabetes mellitus32.5PTPRN, PAX4, LRP5, INS, AKR1B1, HLA-DQA1
2thyroiditis31.3GAD2, CTLA4
3celiac disease31.2HLA-DQA1, HLA-DQB1
4diabetic retinopathy31.2GAD1, AKR1B1, INS
5hypoglycemia31.1INS, AKR1B1, GAD1, LSL
6autoimmune thyroiditis31.1CTLA4, GAD2, GAD1
7pancreatitis31.1INS
8diabetic ketoacidosis31.1LSL, CTLA4, GAD2, GAD1, INS
9diabetic neuropathy31.1GAD2, GAD1, AKR1B1, INS
10neuropathy31.1AKR1B1, INS
11type 2 diabetes mellitus31.0IDDM2, LSL, GAD2, GAD1, AKR1B1, INS
12graves' disease30.9PTPRN, HLA-DQA1, HLA-DQB1, GAD1, GAD2, CTLA4
13autonomic neuropathy30.9GAD2, GAD1, AKR1B1, INS
14obesity30.9LSL, GAD2, AKR1B1, INS
15diabetic autonomic neuropathy30.9MLNR, AKR1B1
16hyperglycemia30.9LSL, GAD2, GAD1, AKR1B1, INS, PAX4
17hepatitis30.9CTLA4
18type 1 diabetes30.8CSN2, CTLA4, GAD2, GAD1, INS, PTPRN
19dermatitis30.8CTLA4
20glucose intolerance30.7LSL, GAD1, INS
21insulinoma30.5GAD2, GAD1, INS, PAX4, PTPRN
22hypothyroidism30.5LSL, CTLA4, INS
23gastroparesis30.5MLNR, INS
24hypertension30.5INS
25addison's disease30.5CTLA4
26dermatitis herpetiformis30.5HLA-DQB1
27liver cirrhosis30.5LSL
28hyperinsulinism30.5LSL, INS, PAX4
29multiple sclerosis30.4LSL, CSN2, CTLA4, GAD1, HLA-DQB1, HLA-DQA1
30gestational diabetes30.4LSL, GAD1, INS, PTPRN
31hepatitis b30.4AKR1B1, HLA-DQA1, HLA-DQB1
32maturity-onset diabetes of the young30.4PAX4, INS
33proliferative diabetic retinopathy30.4GAD1
34polycystic ovary syndrome30.4INS, LSL
35viral hepatitis30.3HLA-DQA1
36cystic fibrosis30.3HLA-DQA1, INS
37acquired immunodeficiency syndrome30.3KIR2DL2
38rheumatoid arthritis30.2HLA-DQB1, CTLA4
39arthritis30.2CTLA4
40influenza30.2KIR2DL2
41ischemia30.2AKR1B1, GAD1, GAD2
42glomerulonephritis30.2NAGA
43asthma30.2HLA-DQA1, CTLA4
44retinal disease30.2INS, AKR1B1, GAD1
45lymphopenia29.8IDDM2
46diabetic nephropathy10.9
47periodontitis10.6
48diabetic polyneuropathy10.6
49polyneuropathy10.6
50atherosclerosis10.6

Graphical network of the top 20 diseases related to Type 1 Diabetes Mellitus:



Diseases related to type 1 diabetes mellitus

Clinical Features for Type 1 Diabetes Mellitus

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46OMIM
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Clinical features from OMIM:

222100

Drugs & Therapeutics for Type 1 Diabetes Mellitus

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Type 1 Diabetes Mellitus

Drug clinical trials:

Search ClinicalTrials for Type 1 Diabetes Mellitus

Search NIH Clinical Center for Type 1 Diabetes Mellitus

Search CenterWatch for Type 1 Diabetes Mellitus

Inferred drug relations via UMLS60/NDF-RT40:

Show with subtypes

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Type 1 Diabetes Mellitus cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Type 1 Diabetes Mellitus:
Bone marrow-derived adult mesenchymal stem cells for treatment of type I diabetes
Dendritic cells for type I diabetes
DIABECELL
Endothelial progenitor cell and islet cotransplantation for diabetes
Hematopoietic stem cell transplantation for new-onset type 1 diabetes
Hematopoietic stem cells for early-onset type I diabetes mellitus
Hematopoietic stem cells for treatment of early-onset type I diabetes mellitus
Hematopoietic stem cells for type I diabetes mellitus
Human islet transplantation to treat diabetes
Porcine embryonic pancreatic tissue transplantation for diabetes
Prochymal
Regulatory T cells for type I diabetes
StemGenex
Umbilical cord-derived mesenchymal stem cells for treatment of type I diabetes
VC-01, embryonic stem cell-derived pancreatic progenitor cells for treatment of diabetes
Embryonic/Adult Cultured Cells Related to Type 1 Diabetes Mellitus:
Bone marrow-derived mesenchymal stem cells (family)
Mouse immunosuppressive dendritic cells, PMIDs: 17665986, 18552749, 23148758
Immunosuppressive dendritic cells, PMIDs: 17665986, 18552749, 23148758
Encapsulated neonatal porcine islets (DIABECELL, PMIDs: 15808678, 18814261, 17607741, 21358330, 21535153, 16131605, 23088180, 19063691, 16298643, 11202575, 17381690
Mouse Islets, PMID: 22362173
Umbilical cord blood-derived endothelial progenitor cells, PMID: 22362173
Pancreatic islets, PMID: 22362173
Peripheral blood-derived hematopoietic stem cells (family), PMID: 23190701
Peripheral blood-derived hematopoietic stem cells, PMID: 23190701
Peripheral blood-derived hematopoietic stem cells , PMID: 23190701
Bone marrow-derived hematopoietic stem cells (family)
Pancreatic islets (cadavers), PMIDs: 15983207, 10911004
Fetal pancreatic tissue, PMIDs: 16768546, 19433788
Regulatory T cells, PMIDs: 15322272, 16903917
Adipose-derived stem cells (StemGenex
Umbilical cord-derived mesenchymal stem cells (family)
Pancreatic endoderm/endocrine precursor-like cells, PMIDs: 18834446, 22623968, 18034635

Genetic Tests for Type 1 Diabetes Mellitus

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22GTR
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Genetic tests related to Type 1 Diabetes Mellitus:

id Genetic test Affiliating Genes
1 Diabetes Mellitus Type 122

Anatomical Context for Type 1 Diabetes Mellitus

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30LifeMap Discovery™, 32MalaCards
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MalaCards organs/tissues related to Type 1 Diabetes Mellitus:

32
Endothelial, Bone, Thyroid, Pancreas, T cells, Pancreatic islet, Heart, Kidney, Testes, Bone marrow, Skin, Brain, Pituitary, Liver, Ovary, Monocytes, Colon, Small intestine, Placenta, Retina, B cells, Myeloid, Breast, Adipocyte, Cortex, Whole blood

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Type 1 Diabetes Mellitus:
id TissueAnatomical CompartmentCell Relevance
1 BoneBone MarrowBone Marrow Stromal Cells Potential therapeutic candidate
2 PancreasIslets of LangerhansMature Beta Cells Potential therapeutic candidate, affected by disease
3 BloodCord BloodMesenchymal Stem Cells Potential therapeutic candidate
4 AdiposeSubcutaneous White AdiposeMesenchymal Stem Cells Potential therapeutic candidate
5 Umbilical CordWharton's JellyMesenchymal Stem Cells Potential therapeutic candidate
6 AdiposeSubcutaneous White AdiposeStromal Cells Potential therapeutic candidate

Animal Models for Type 1 Diabetes Mellitus or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Type 1 Diabetes Mellitus:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000287311.0PAX4, LRP5, INS, HLA-DQB1, GAD1, GAD2
2MP:000537910.3PTPRN, GAD2

Publications for Type 1 Diabetes Mellitus

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50PubMed
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Articles related to Type 1 Diabetes Mellitus:

(show top 50)    (show all 1243)
idTitleAuthorsYear
1
Effectiveness of groups for adolescents with type 1 diabetes mellitus and their parents. (23957874)
2013
2
Growth status of children and adolescents with type 1 diabetes mellitus. (24381884)
2013
3
Corticotropic axis drive of overnight cortisol secretion is suppressed in adolescents and young adults with type 1 diabetes mellitus. (24350820)
2013
4
Detecting intentional insulin omission for weight loss in girls with type 1 diabetes mellitus. (23674378)
2013
5
Xenotransplantation of exendin-4 gene transduced pancreatic islets using multi-component (alginate, poly-L-lysine, and polyethylene glycol) microcapsules for the treatment of type 1 diabetes mellitus. (23905775)
2013
6
Identifying common and specific microRNAs expressed in peripheral blood mononuclear cell of type 1, type 2, and gestational diabetes mellitus patients. (24279768)
2013
7
The incidence of severe hypoglycaemia in pregnant women with type 1 diabetes mellitus can be reduced with unchanged HbA1c levels and pregnancy outcomes in a routine care setting. (23820486)
2013
8
The role of interferon induced with helicase C domain 1 (IFIH1) in the development of type 1 diabetes mellitus. (24402011)
2013
9
Transplantation: Pancreas-kidney transplantation may reduce fracture risk in men with type 1 diabetes mellitus. (23338207)
2013
10
Effects of switching from insulin glargine or detemir to insulin degludec in patients with type 1 diabetes mellitus. (24282104)
2013
11
Does eating during television viewing affect mealtimes in young children with type 1 diabetes mellitus? (23273663)
2013
12
Viruses and vitamin D in the etiology of type 1 diabetes mellitus and multiple sclerosis. (22119899)
2012
13
Erratum to: Suppressive effects of natural reduced waters on alloxan-induced apoptosis and type 1 diabetes mellitus. (22573290)
2012
14
Relation between carotid intima-media thickness and left ventricular mass in type 1 diabetes mellitus (from the Epidemiology of Diabetes Interventions and Complications [EDIC] Study). (22884107)
2012
15
Socioeconomic factors, rather than diabetes mellitus per se, contribute to an excessive use of antidepressants among young adults with childhood onset type 1 diabetes mellitus: a register-based study. (22179222)
2012
16
Continuous glucose monitoring in children, adolescents, and adults with type 1 diabetes mellitus: analysis from the prospective DPV diabetes documentation and quality management system from Germany and Austria. (22128781)
2012
17
Urinary markers of renal inflammation in adolescents with Type 1 diabetes mellitus and normoalbuminuria. (22416821)
2012
18
Recognition, prevention, and proactive management of hypoglycemia in patients with type 1 diabetes mellitus. (21680991)
2011
19
Complementary and alternative medicine in children with type 1 diabetes mellitus. (21911327)
2011
20
Use of a novel fluorescent glucose sensor in volunteer subjects with type 1 diabetes mellitus. (21722584)
2011
21
Long-term renal outcomes of patients with type 1 diabetes mellitus and microalbuminuria: an analysis of the DCCT/EDIC cohort. (21949179)
2011
22
HLA-DQ A1, -DQB1 and -DRB1 gene polymorphism--in Malay type 1 diabetes mellitus patients and their use for risk prediction. (22106694)
2011
23
Glycated albumin levels are higher relative to HbA1c levels in people with autoimmune acute-onset type 1 diabetes mellitus than in people with type 2 diabetes mellitus at the time of diagnosis. (21777990)
2011
24
Lymphocyte activation in type 1 diabetes mellitus: the increased significance of Kv1.3 potassium channels. (20603149)
2010
25
Type 1 diabetes mellitus and Rett syndrome: is there a link? (21293173)
2010
26
Insulin is a stronger inducer of insulin resistance than hyperglycemia in mice with type 1 diabetes mellitus (T1DM). (19654321)
2009
27
Prevalence of atopy in children with type 1 diabetes mellitus, hepatitis B virus carriers, and healthy children: role of T helper 1 (Th1)-type immune response. (18430314)
2008
28
Variation in associations between allelic variants of the vitamin D receptor gene and onset of type 1 diabetes mellitus by ambient winter ultraviolet radiation levels: a meta-regression analysis. (18552362)
2008
29
Microvascular diabetes complications in Wolfram syndrome (diabetes insipidus, diabetes mellitus, optic atrophy, and deafness [DIDMOAD]): an age- and duration-matched comparison with common type 1 diabetes. (17536072)
2007
30
Hormonal profile in women with polycystic ovarian syndrome with or without type 1 diabetes mellitus. (17895317)
2007
31
Mononuclear and polymorphonuclear leukocytes show increased fructose-1,6-bisphosphatase activity in patients with type 1 diabetes mellitus. (16725352)
2006
32
Association of childhood type 1 diabetes mellitus with a variant of PAX4: possible link to beta cell regenerative capacity. (15834548)
2005
33
Altered response of insulin-like growth factor-binding protein 1 to nutritional deprivation in type 2 diabetes mellitus. (15736102)
2005
34
Coincidence of multiple endocrine neoplasia type IIa and type 1 diabetes mellitus. (16279372)
2005
35
Screening for associated autoimmunity in type 1 diabetes mellitus with respect to diabetes control. (15717840)
2005
36
Interleukin IL-18 gene promoter polymorphisms in adult patients with type 1 diabetes mellitus and latent autoimmune diabetes in adults. (15585330)
2005
37
A novel polymorphism in the 5' flanking region of the glucose transporter (GLUT1) gene is strongly associated with diabetic nephropathy in patients with Type 1 diabetes mellitus. (15745834)
2005
38
Enhanced P-selectin expression and increased soluble CD40 Ligand in patients with Type 1 diabetes mellitus and microangiopathy: evidence for platelet hyperactivity and chronic inflammation. (14963650)
2004
39
Association study of human MTH1 gene polymorphisms with type 1 diabetes mellitus. (15516784)
2004
40
Oral modified insulin (HIM2) in patients with type 1 diabetes mellitus: results from a phase I/II clinical trial. (14681842)
2004
41
Polymorphisms of HLA class II predispose children and adolescents with type 1 diabetes mellitus to autoimmune thyroid disease. (12911285)
2003
42
Peripheral arterial disease in diabetes mellitus type 1 and type 2: are there different risk factors? (12510549)
2002
43
Immune reactivity to GAD25 in type 1 diabetes mellitus. (12515288)
2002
44
Urinary excretion of glucagon-like peptide 1 (GLP-1) 7-36 amide in human type 2 (non-insulin-dependent) diabetes mellitus. (11561219)
2001
45
Insulin infusion normalizes fasting and post-prandial albumin and fibrinogen synthesis in Type 1 diabetes mellitus. (11703437)
2001
46
Type 1 diabetes mellitus in early childhood: glycemic control and associated risk of hypoglycemic reactions. (10089987)
1999
47
Leptin levels in non-obese and obese children and young adults with type 1 diabetes mellitus. (9703378)
1998
48
Plasma disappearance of glycated and non-glycated albumin in type 1 (insulin-dependent) diabetes mellitus: evidence for charge dependent alterations of the plasma to lymph pathway. (8477883)
1993
49
Transfer of type 1 (insulin-dependent) diabetes mellitus associated autoimmunity to mice with severe combined immunodeficiency (SCID). (8335172)
1993
50
Comparative evaluation of the effectiveness of insulin preparations "Lente GP" and "Insulong" in type 1 diabetes mellitus]. (1798933)
1991

Genetic Variations for Type 1 Diabetes Mellitus

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Expression for genes affiliated with Type 1 Diabetes Mellitus

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Type 1 Diabetes Mellitus

Search GEO for disease gene expression data for Type 1 Diabetes Mellitus.

Pathways for genes affiliated with Type 1 Diabetes Mellitus

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29KEGG, 51QIAGEN, 53Reactome, 37NCBI BioSystems Database, 12EMD Millipore
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Compounds for genes affiliated with Type 1 Diabetes Mellitus

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 59Tocris Bioscience, 2BitterDB, 49PharmGKB
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Compounds related to Type 1 Diabetes Mellitus according to GeneCards/GeneDecks:

(show all 26)
idCompoundScoreTop Affiliating Genes
1glucose4411.6PTPRN, LSL, CTLA4, GAD2, GAD1, AKR1B1
2alanine4411.4LSL, CTLA4, GAD2, GAD1, AKR1B1, MLNR
3cholesterol44 28 11 2414.3LSL, CTLA4, GAD2, GAD1, INS, LRP5
4c-peptide4411.2LSL, GAD2, GAD1, INS, PTPRN
5glycerol44 11 2413.2INS, NAGA, AKR1B1, CSN2, LSL
6arginine4411.2LSL, GAD1, HLA-DQA1, AKR1B1, INS, PTPRN
7cyclosporin a44 28 5913.2CTLA4, GAD2, GAD1, AKR1B1, PTPRN
8hydrogen44 2412.1LSL, CSN2, GAD2, GAD1, AKR1B1
9estrogen4411.1LSL, CSN2, CTLA4, AKR1B1, INS, LRP5
10glutamate4411.1CSN2, GAD2, GAD1, PTPRN
11taurine44 59 2413.1AKR1B1, GAD1, GAD2
12valproate4411.0LSL, GAD1, AKR1B1
13pyridoxal 5-phosphate4411.0GAD2, GAD1, AKR1B1
14streptozotocin4411.0INS, AKR1B1, GAD1
15hbig4411.0INS, AKR1B1
16levodopa44 1111.9AKR1B1, GAD1, GAD2
17cysteine sulfinic acid4410.9GAD1, GAD2
18hypotaurine59 44 2412.9GAD2, GAD1
19carbon dioxide44 2411.9LSL, GAD2, GAD1
203-Sulfinoalanine11 2411.9GAD1, GAD2
21haloperidol44 28 2 49 1114.8LSL, GAD1, AKR1B1
22sibutramine44 1111.7INS, LSL
23beta-hydroxybutyrate4410.6INS, LSL
24acipimox44 2811.6INS, LSL
25oligonucleotide4410.6CSN2, GAD2, GAD1, HLA-DQB1, HLA-DQA1
26repaglinide44 49 1112.5PAX4, INS

GO Terms for genes affiliated with Type 1 Diabetes Mellitus

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16Gene Ontology
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Cellular components related to Type 1 Diabetes Mellitus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:00588611.2CTLA4, GAD2, GAD1, HLA-DQB1, HLA-DQA1, MLNR
2integral to plasma membraneGO:00588710.6TNFSF12, CTLA4, HLA-DQA1, MLNR, KIR2DS5, PTPRN
3clathrin-sculpted gamma-aminobutyric acid transport vesicle membraneGO:06120210.6GAD1, GAD2
4MHC class II protein complexGO:04261310.6HLA-DQA1, HLA-DQB1

Biological processes related to Type 1 Diabetes Mellitus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1immune responseGO:00695510.9KIR2DS5, KIR2DS2, HLA-DQA1, HLA-DQB1, CTLA4, TNFSF12
2neurotransmitter biosynthetic processGO:04213610.6GAD1, GAD2
3glutamate decarboxylation to succinateGO:00654010.5GAD2, GAD1
4T cell costimulationGO:03129510.4HLA-DQA1, HLA-DQB1, CTLA4

Molecular functions related to Type 1 Diabetes Mellitus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glutamate decarboxylase activityGO:00435110.6GAD1, GAD2
2MHC class II receptor activityGO:03239510.6HLA-DQA1, HLA-DQB1
3aldo-keto reductase (NADP) activityGO:00403310.5MIOX, AKR1B1
4glutamate bindingGO:01659510.3GAD1, GAD2

Products for genes affiliated with Type 1 Diabetes Mellitus

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Type 1 Diabetes Mellitus

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet