IDDM
MCID: TYP008
MIFTS: 71

Type 1 Diabetes Mellitus (IDDM) malady

Summaries for Type 1 Diabetes Mellitus

Sources:
8Disease Ontology, 47OMIM, 33MalaCards
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Disease Ontology:8 A diabetes mellitus that results from the body's failure to produce insulin and has material basis in autoimmune destruction of insulin-producing beta cells of the pancreas.

MalaCards: Type 1 Diabetes Mellitus, also known as diabetes mellitus type 1, is related to type 1 diabetes and celiac disease. An important gene associated with Type 1 Diabetes Mellitus is LRP5 (low density lipoprotein receptor-related protein 5), and among its related pathways are Allograft rejection and Allograft rejection. The drugs insulin and insulin, aspart, human and the compounds glucose and alanine have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, whole blood and heart, and related mouse phenotypes are normal and endocrine/exocrine gland.

Description from OMIM:47 222100

Aliases & Classifications for Type 1 Diabetes Mellitus

Sources:
8Disease Ontology, 31LifeMap Discovery™, 9diseasecard, 43NIH Rare Diseases, 22GTR, 61UMLS, 57SNOMED-CT, 35MeSH, 40NCIt, 47OMIM
See all sources

Aliases & Descriptions:

type 1 diabetes mellitus 8 31
diabetes mellitus type 1 43 22
diabetes mellitus, insulin-dependent, susceptibility to 9
diabetes mellitus, insulin dependent 43
diabetes mellitus, insulin-dependent 61
insulin-dependent diabetes mellitus 8
type i diabetes mellitus 8
iddm 8


External Ids:

Disease Ontology8 DOID:9744
MeSH35 D003922
NCIt40 C2986
OMIM47 222100

Related Diseases for Type 1 Diabetes Mellitus

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the type 2 diabetes mellitus family:

type 1 diabetes mellitus diabetes mellitus

Diseases related to Type 1 Diabetes Mellitus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 282)
idRelated DiseaseScoreTop Affiliating Genes
1type 1 diabetes31.3CSN2, CTLA4, GAD2, GAD1, INS, PTPRN
2celiac disease31.2HLA-DQA1, HLA-DQB1
3hypoglycemia31.2INS, AKR1B1, GAD1, LSL
4thyroiditis31.1GAD2, CTLA4
5type 2 diabetes mellitus31.0IDDM2, LSL, GAD2, GAD1, AKR1B1, INS
6diabetic ketoacidosis31.0LSL, CTLA4, GAD2, GAD1, INS
7graves' disease31.0PTPRN, HLA-DQA1, HLA-DQB1, GAD1, GAD2, CTLA4
8autonomic neuropathy30.9GAD2, GAD1, AKR1B1, INS
9autoimmune thyroiditis30.9CTLA4, GAD2, GAD1
10insulin resistance30.8PAX4, INS, NAGA, GAD2, LSL
11glucose intolerance30.7LSL, GAD1, INS
12insulinoma30.6GAD2, GAD1, INS, PAX4, PTPRN
13hyperinsulinism30.6LSL, INS, PAX4
14gastroparesis30.6MLNR, INS
15proliferative diabetic retinopathy30.4GAD1
16polycystic ovary syndrome30.4INS, LSL
17viral hepatitis30.3HLA-DQA1
18cystic fibrosis30.3HLA-DQA1, INS
19acquired immunodeficiency syndrome30.3KIR2DL2
20gestational diabetes30.2LSL, GAD1, INS, PTPRN
21diabetic autonomic neuropathy30.2MLNR, AKR1B1
22addison's disease30.2CTLA4
23arthritis30.2CTLA4
24asthma30.2HLA-DQA1, CTLA4
25diabetic nephropathy10.8
26diabetes, type 210.7
27diabetes mellitus, insulin-dependent-110.7
28atherosclerosis10.6
29insulin autoimmune syndrome10.5
30coronary heart disease10.5
31hepatitis c10.5
32hepatitis d10.5
33hepatitis a10.5
34diabetic polyneuropathy10.5
35histiocytosis-lymphadenopathy plus syndrome10.5
36diabetes mellitus, insulin-dependent, 1910.5
37hypertriglyceridemia10.5
38atopic dermatitis10.4
39adjustment disorder10.4
40frozen shoulder10.4
41down syndrome10.4
42autoimmune polyendocrine syndrome10.4
43nephropathy-hypertension10.4
44diabetes mellitus, insulin-dependent, 710.4
45diabetes mellitus, insulin-dependent, 2210.4
46diabetes mellitus, insulin-dependent, 2310.4
47diabetes mellitus, insulin-dependent, 1810.4
48diabetes mellitus, insulin-dependent, neonatal10.4
49diabetes mellitus, insulin-dependent, 2110.4
50diabetes mellitus, insulin-dependent, 510.4

Graphical network of the top 20 diseases related to Type 1 Diabetes Mellitus:



Diseases related to type 1 diabetes mellitus

Clinical Features for Type 1 Diabetes Mellitus

Sources:
47OMIM
See all sources

Clinical features from OMIM:

222100

Drugs & Therapeutics for Type 1 Diabetes Mellitus

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Type 1 Diabetes Mellitus

Drug clinical trials:

Search ClinicalTrials for Type 1 Diabetes Mellitus

Search NIH Clinical Center for Type 1 Diabetes Mellitus

Search CenterWatch for Type 1 Diabetes Mellitus

Inferred drug relations via UMLS61/NDF-RT41:

Show with subtypes

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Type 1 Diabetes Mellitus cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Type 1 Diabetes Mellitus:
Bone marrow-derived adult mesenchymal stem cells for treatment of type I diabetes
Dendritic cells for type I diabetes
DIABECELL
Endothelial progenitor cell and islet cotransplantation for diabetes
Hematopoietic stem cell transplantation for new-onset type 1 diabetes
Hematopoietic stem cells for early-onset type I diabetes mellitus
Hematopoietic stem cells for treatment of early-onset type I diabetes mellitus
Hematopoietic stem cells for type I diabetes mellitus
Human islet transplantation to treat diabetes
Porcine embryonic pancreatic tissue transplantation for diabetes
Prochymal
Regulatory T cells for type I diabetes
StemGenex
Umbilical cord-derived mesenchymal stem cells for treatment of type I diabetes
VC-01, embryonic stem cell-derived pancreatic progenitor cells for treatment of diabetes
Embryonic/Adult Cultured Cells Related to Type 1 Diabetes Mellitus:
Bone marrow-derived mesenchymal stem cells (family)
Mouse immunosuppressive dendritic cells, PMIDs: 17665986, 18552749, 23148758
Immunosuppressive dendritic cells, PMIDs: 17665986, 18552749, 23148758
Encapsulated neonatal porcine islets (DIABECELL, PMIDs: 15808678, 18814261, 17607741, 21358330, 21535153, 16131605, 23088180, 19063691, 16298643, 11202575, 17381690
Mouse Islets, PMID: 22362173
Umbilical cord blood-derived endothelial progenitor cells, PMID: 22362173
Pancreatic islets, PMID: 22362173
Peripheral blood-derived hematopoietic stem cells (family), PMID: 23190701
Peripheral blood-derived hematopoietic stem cells, PMID: 23190701
Peripheral blood-derived hematopoietic stem cells , PMID: 23190701
Bone marrow-derived hematopoietic stem cells (family)
Pancreatic islets (cadavers), PMIDs: 15983207, 10911004
Fetal pancreatic tissue, PMIDs: 16768546, 19433788
Regulatory T cells, PMIDs: 15322272, 16903917
Adipose-derived stem cells (StemGenex
Umbilical cord-derived mesenchymal stem cells (family)
Pancreatic endoderm/endocrine precursor-like cells, PMIDs: 18834446, 22623968, 18034635

Genetic Tests for Type 1 Diabetes Mellitus

Sources:
22GTR
See all sources

Genetic tests related to Type 1 Diabetes Mellitus:

id Genetic test Affiliating Genes
1 Diabetes Mellitus Type 122

Anatomical Context for Type 1 Diabetes Mellitus

Sources:
31LifeMap Discovery™, 33MalaCards
See all sources

MalaCards organs/tissues related to Type 1 Diabetes Mellitus:

33
Bone marrow, Whole blood, Heart, Pancreas, Thyroid, T cells, Endothelial, Pancreatic islet

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Type 1 Diabetes Mellitus:
id TissueAnatomical CompartmentCell Relevance
1 BoneBone MarrowBone Marrow Stromal Cells Potential therapeutic candidate
2 PancreasIslets of LangerhansMature Beta Cells Potential therapeutic candidate, affected by disease
3 BloodCord BloodMesenchymal Stem Cells Potential therapeutic candidate
4 AdiposeSubcutaneous White AdiposeMesenchymal Stem Cells Potential therapeutic candidate
5 Umbilical CordWharton's JellyMesenchymal Stem Cells Potential therapeutic candidate
6 AdiposeSubcutaneous White AdiposeStromal Cells Potential therapeutic candidate

Animal Models for Type 1 Diabetes Mellitus or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Type 1 Diabetes Mellitus:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000287311.0PAX4, LRP5, INS, HLA-DQB1, GAD1, GAD2
2MP:000537910.3PTPRN, GAD2

Publications for Type 1 Diabetes Mellitus

Sources:
51PubMed
See all sources

Articles related to Type 1 Diabetes Mellitus:

(show top 50)    (show all 66)
idTitleAuthorsYear
1
Re: "Prevalence of Diagnosed and Undiagnosed Type 2 Diabetes Mellitus Among US Adolescents: Results From the Continuous NHANES, 1999-2010". (24243744)
2014
2
Efficacy and Safety of ETC-1002, a Novel Investigational Low-Density Lipoprotein-Cholesterol-Lowering Therapy for the Treatment of Patients With Hypercholesterolemia and Type 2 Diabetes Mellitus. (24385236)
2014
3
Re: "Prevalence of Diagnosed and Undiagnosed Type 2 Diabetes Mellitus Among US Adolescents: Results From the Continuous NHANES, 1999-2010". (24243743)
2014
4
Dose response of continuous subcutaneous infusion of recombinant glucagon-like peptide-1 in combination with metformin and sulphonylurea over 12a88weeks in patients with type 2 diabetes mellitus. (24251641)
2013
5
A variable CD3a8_ T-cell frequency in peripheral blood lymphocytes associated with type 1 diabetes mellitus development in the LEW.1AR1-iddm rat. (23717591)
2013
6
The 16-year incidence, progression and regression of diabetic retinopathy in a young population-based Danish cohort with type 1 diabetes mellitus: The Danish cohort of pediatric diabetes 1987 (DCPD1987). (24193810)
2013
7
The association of the 174G>C polymorphism of interleukin 6 gene with diabetic nephropathy in patients with type 2 diabetes mellitus. (23871133)
2013
8
Ambulatory Treatment of Type 2 Diabetes Mellitus in the United States, 1997-2012. (24198301)
2013
9
Association of IL-4-590 C>T and IL-13-1112 C>T gene polymorphisms with the susceptibility to type 2 diabetes mellitus. (24167373)
2013
10
Prevalence of diagnosed and undiagnosed type 2 diabetes mellitus among US adolescents: results from the continuous NHANES, 1999-2010. (23887044)
2013
11
Paradoxical lower serum triglyceride levels and higher type 2 diabetes mellitus susceptibility in obese individuals with the PNPLA3 148M variant. (22724004)
2012
12
Outcome of pregnancy in type 1 diabetes mellitus (T1DMP): results from combined diabetes-obstetrical clinics in Dublin in three university teaching hospitals (1995-2006). (22057636)
2012
13
Association of 1233A/G polymorphism of angiopoietin-2 gene with type 2 diabetes mellitus and diabetic nephropathy]. (22311497)
2012
14
Associations between single-nucleotide polymorphisms (+45T>G, +276G>T, -11377C>G, -11391G>A) of adiponectin gene and type 2 diabetes mellitus: a systematic review and meta-analysis. (21638131)
2011
15
The osteopontin gene +1239A/C single nucleotide polymorphism is associated with type 1 diabetes mellitus in the Italian population. (20378012)
2010
16
Genetic polymorphism c.1562C>T of the MMP-9 is associated with macroangiopathy in type 2 diabetes mellitus. (19909726)
2010
17
Hepatocyte growth factor levels are associated with the results of 123I-metaiodobenzylguanidine myocardial scintigraphy in patients with type 2 diabetes mellitus. (19154948)
2009
18
Gene polymorphisms of TNF-alpha-308 (G/A), IL-10(-1082) (G/A), IL-6(-174) (G/C) and IL-1Ra (VNTR) in Egyptian cases with type 1 diabetes mellitus. (19127455)
2009
19
Association study on the mitochondrial genome region np16181-16193 variation with type 2 diabetes mellitus]. (19504453)
2009
20
National trends in treatment of type 2 diabetes mellitus, 1994-2007. (18955637)
2008
21
The short-term effectiveness of non-surgical treatment in reducing levels of interleukin-1beta and proteases in gingival crevicular fluid from patients with type 2 diabetes mellitus and chronic periodontitis. (18980523)
2008
22
11-Beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) inhibitors in type 2 diabetes mellitus and obesity. (18363514)
2008
23
Sustained IL-1alpha, IL-4, and IL-6 elevations following correction of hyperglycemia in children with type 1 diabetes mellitus. (18211631)
2008
24
A mitochondrial DNA variant at position 16189 is associated with type 2 diabetes mellitus in Asians. (18251004)
2008
25
Genetic variants in the USF1 gene are associated with low-density lipoprotein cholesterol levels and incident type 2 diabetes mellitus in women: results from the MONICA/KORA Augsburg case-cohort study, 1984-2002. (18593823)
2008
26
Association of apolipoprotein A5 gene -1131T/C polymorphism with serum lipids and carotid intima-media thickness in patients with type 2 diabetes mellitus]. (19253837)
2008
27
Genetic association of interleukin-1beta (-511C/T) and interleukin-1 receptor antagonist (86 bp repeat) polymorphisms with Type 2 diabetes mellitus in North Indians. (17069782)
2007
28
IL-18 gene promoter -137C/G and -607C/A polymorphisms in Chinese Han children with type 1 diabetes mellitus. (17373930)
2007
29
Association of VEGF-1499C-->T polymorphism with diabetic nephropathy in type 1 diabetes mellitus. (17616354)
2007
30
Association of apolipoprotein A5 gene -1131T/C polymorphism with lipid metabolism and insulin resistance in patients with type II diabetes mellitus]. (17548321)
2007
31
Association of microsatellite polymorphisms of the human 14q13.2 region with type 2 diabetes mellitus in Latvian and Finnish populations. (17535269)
2007
32
The peroxisome proliferator-activated receptor gamma coactivator-1 alpha gene (PGC-1alpha) is not associated with type 2 diabetes mellitus or body mass index among Hispanic and non Hispanic Whites from Colorado. (17479445)
2007
33
Association between plasma IL-6, the IL6 -174G>C gene variant and the metabolic syndrome in type 2 diabetes mellitus. (17123852)
2007
34
Interleukin-12p40 gene (IL-12B) polymorphism and Type 1 diabetes mellitus in Japanese: possible role in subjects without having high-risk HLA haplotypes. (16005098)
2006
35
WRN gene 1367 Arg allele protects against development of type 2 diabetes mellitus. (16098926)
2005
36
Apolipoprotein A5 gene polymorphism -1131T-->C: association with plasma lipids and type 2 diabetes mellitus with coronary heart disease in Chinese. (16006256)
2005
37
11beta-hydroxysteroid dehydrogenase type 1 activity in lean and obese males with type 2 diabetes mellitus. (15356090)
2004
38
The C-174G promoter polymorphism of the interleukin-6 (IL-6) gene that affects insulin sensitivity in Caucasians is not involved in the pathogenesis of Taiwanese type 2 diabetes mellitus. (15319170)
2004
39
Peroxisome proliferator-activated receptor-gamma coactivator-1alpha polymorphism is not associated with essential hypertension and type 2 diabetes mellitus in Chinese population. (15824463)
2004
40
Ex vivo lipopolysaccharide (LPS)-induced TNF-alpha, IL-1beta, IL-6 and PGE2 secretion in whole blood from Type 1 diabetes mellitus patients with or without aggressive periodontitis. (14656685)
2003
41
Association study of the vitamin D: 1alpha-hydroxylase (CYP1alpha) gene and type 2 diabetes mellitus in a Polish population. (12746631)
2003
42
C-106T polymorphism of AKR1B1 is associated with diabetic nephropathy and erythrocyte aldose reductase content in Japanese subjects with type 2 diabetes mellitus. (14582038)
2003
43
IL-6 gene polymorphism -174G/C does not contribute substantially to hyperlipidaemia and Type II diabetes mellitus in Japanese men. (11914754)
2002
44
Association studies between the HSD11B2 gene (encoding human 11beta-hydroxysteroid dehydrogenase type 2), type 1 diabetes mellitus and diabetic nephropathy. (11916625)
2002
45
Vitamin D 1alpha-hydroxylase (CYP1alpha) polymorphism in Graves' disease, Hashimoto's thyroiditis and type 1 diabetes mellitus. (12039697)
2002
46
Studies of the variability of the hepatocyte nuclear factor-1beta (HNF-1beta / TCF2) and the dimerization cofactor of HNF-1 (DcoH / PCBD) genes in relation to type 2 diabetes mellitus and beta-cell function. (11668623)
2001
47
Long-term effects of the endothelin(A) receptor antagonist LU 135252 and the angiotensin-converting enzyme inhibitor trandolapril on diabetic angiopathy and nephropathy in a chronic type I diabetes mellitus rat model. (10773002)
2000
48
Molecular genetics of diabetes mellitus in Chinese subjects: identification of mutations in glucokinase and hepatocyte nuclear factor-1alpha genes in patients with early-onset type 2 diabetes mellitus/MODY. (10588527)
1999
49
Banting lecture 1990. Beta-cells in type II diabetes mellitus. (1991568)
1991
50
Pathogenic factors in the development of type I and type II diabetes mellitus: 1990. (2233139)
1990

Genetic Variations for Type 1 Diabetes Mellitus

Expression for genes affiliated with Type 1 Diabetes Mellitus

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Type 1 Diabetes Mellitus

Search GEO for disease gene expression data for Type 1 Diabetes Mellitus.

Pathways for genes affiliated with Type 1 Diabetes Mellitus

Sources:
30KEGG, 52QIAGEN, 54Reactome, 38NCBI BioSystems Database, 12EMD Millipore
See all sources

Compounds for genes affiliated with Type 1 Diabetes Mellitus

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 24HMDB, 60Tocris Bioscience, 2BitterDB, 50PharmGKB
See all sources

Compounds related to Type 1 Diabetes Mellitus according to GeneCards/GeneDecks:

(show all 26)
idCompoundScoreTop Affiliating Genes
1glucose4511.6PTPRN, LSL, CTLA4, GAD2, GAD1, AKR1B1
2alanine4511.4LSL, CTLA4, GAD2, GAD1, AKR1B1, MLNR
3cholesterol45 29 11 2414.3LSL, CTLA4, GAD2, GAD1, INS, LRP5
4c-peptide4511.2LSL, GAD2, GAD1, INS, PTPRN
5glycerol45 11 2413.2INS, NAGA, AKR1B1, CSN2, LSL
6arginine4511.2LSL, GAD1, HLA-DQA1, AKR1B1, INS, PTPRN
7cyclosporin a45 29 6013.2CTLA4, GAD2, GAD1, AKR1B1, PTPRN
8hydrogen45 2412.1LSL, CSN2, GAD2, GAD1, AKR1B1
9estrogen4511.1LSL, CSN2, CTLA4, AKR1B1, INS, LRP5
10glutamate4511.1CSN2, GAD2, GAD1, PTPRN
11taurine45 60 2413.1AKR1B1, GAD1, GAD2
12valproate4511.0LSL, GAD1, AKR1B1
13pyridoxal 5-phosphate4511.0GAD2, GAD1, AKR1B1
14streptozotocin4511.0INS, AKR1B1, GAD1
15hbig4511.0INS, AKR1B1
16levodopa45 1111.9AKR1B1, GAD1, GAD2
17cysteine sulfinic acid4510.9GAD1, GAD2
18hypotaurine60 45 2412.9GAD2, GAD1
19carbon dioxide45 2411.9LSL, GAD2, GAD1
203-Sulfinoalanine11 2411.9GAD1, GAD2
21haloperidol45 29 2 50 1114.8LSL, GAD1, AKR1B1
22sibutramine45 1111.7INS, LSL
23beta-hydroxybutyrate4510.6INS, LSL
24acipimox45 2911.6INS, LSL
25oligonucleotide4510.6CSN2, GAD2, GAD1, HLA-DQB1, HLA-DQA1
26repaglinide45 50 1112.5PAX4, INS

GO Terms for genes affiliated with Type 1 Diabetes Mellitus

Sources:
16Gene Ontology
See all sources

Cellular components related to Type 1 Diabetes Mellitus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:00588611.2CTLA4, GAD2, GAD1, HLA-DQB1, HLA-DQA1, MLNR
2integral to plasma membraneGO:00588710.6TNFSF12, CTLA4, HLA-DQA1, MLNR, KIR2DS5, PTPRN
3clathrin-sculpted gamma-aminobutyric acid transport vesicle membraneGO:06120210.6GAD1, GAD2
4MHC class II protein complexGO:04261310.6HLA-DQA1, HLA-DQB1

Biological processes related to Type 1 Diabetes Mellitus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1immune responseGO:00695510.9KIR2DS5, KIR2DS2, HLA-DQA1, HLA-DQB1, CTLA4, TNFSF12
2neurotransmitter biosynthetic processGO:04213610.6GAD1, GAD2
3glutamate decarboxylation to succinateGO:00654010.5GAD2, GAD1
4T cell costimulationGO:03129510.4HLA-DQA1, HLA-DQB1, CTLA4

Molecular functions related to Type 1 Diabetes Mellitus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glutamate decarboxylase activityGO:00435110.6GAD1, GAD2
2MHC class II receptor activityGO:03239510.6HLA-DQA1, HLA-DQB1
3aldo-keto reductase (NADP) activityGO:00403310.5MIOX, AKR1B1
4glutamate bindingGO:01659510.3GAD1, GAD2

Products for genes affiliated with Type 1 Diabetes Mellitus

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Type 1 Diabetes Mellitus

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet