Type 1 Diabetes Mellitus malady

Disease Ontology: A diabetes mellitus that results from the body's failure to produce insulin and has material basis in autoimmune destruction of insulin-producing beta cells of the pancreas.⁶

MalaCards: Type 1 Diabetes Mellitus, also known as diabetes mellitus, insulin-dependent, is related to type 2 diabetes mellitus and diabetes mellitus. An important gene associated with Type 1 Diabetes Mellitus is LRP5 (low density lipoprotein receptor-related protein 5), and among its related pathways are Antigen processing and presentation and Cell adhesion molecules (CAMs). The drugs chromium picolinate and insulin,nph,pork/purified and the compounds sialic acid and gold have been mentioned in the context of this disorder. Affiliated tissues include whole blood, brain and kidney, and related mouse phenotypes are hematopoietic system and craniofacial.

Wikipedia: Diabetes mellitus type⁴⁴ more...

OMIM: 222100

Aliases & Descriptions:

type 1 diabetes mellitus 6 diabetes mellitus, insulin-dependent 33 43 diabetes mellitus insulin-dependent 32 insulin-dependent diabetes mellitus 6

diabetes mellitus, type i 33 diabetes mellitus, type 1 33 diabetes mellitus 43 iddm 6

Disease types for type 1 diabetes mellitus family:

diabetes mellitus	type 2 diabetes mellitus

Diseases related to type 1 diabetes mellitus by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1124)

id	Related Disease	Score	Top Affiliating Genes
1	type 2 diabetes mellitus	41.3	VWF, GCK, GCG, RBP4, SELE, SELL
2	diabetes mellitus	36.6	PIK3C2A, PIK3CG, LRP5, PDCD1, PDCD1LG2, REN
3	hypertension	36.5	REN, NOS2, NOS3, ACE, AGT, AGTR1
4	maturity-onset diabetes of the young	34.3	GCK, GCG, VDR, PAX4, CELA3B, INS
5	hepatitis	34.0	RBP4, SELP, XDH, GSR, FAS, IFNA2
6	gestational diabetes	33.9	GCK, GCG, RBP4, NAMPT, LEP, LEPR
7	retinol binding protein	33.9	RBP4, NAGLU, NAMPT, LEP, LCN2, XDH
8	autoimmune thyroiditis	33.8	CD40, IL12B, IL2RA, IL4, FAS, IFNG
9	alcoholism	33.6	SCT, GSR, IL1RN, ALDH2, GHRL, CRH
10	autonomic neuropathy	32.8	REN, GCG, MLN, MLNR, INS, IL2RA
11	diabetes, type 2	32.6	GCG, SELE, INS, IL18, ALB, PTPN22
12	polycystic ovary syndrome	32.5	LEP, AR, INS, INSR, IGFBP1, IGF2
13	acid-labile subunit	32.3	BMP7, APOA1, IGFBP1, IGF2, IGFBP2, IGFBP3
14	liver cirrhosis	32.3	REN, GCG, RBP4, SCT, LEPR, XDH
15	hypoparathyroidism	32.1	PIK3C2A, NAGLU, VDR, BGLAP, MTHFR, INS
16	anovulation	32.1	LEP, INS, IGFBP1, IGFBP3, IGF1, GHRL
17	pulmonary tuberculosis	31.7	VDR, CD14, IL10, IL12B, IL18, IL2
18	hyperandrogenism	31.6	REN, NAMPT, LEP, AR, INS, INSR
19	multiple sclerosis	31.6	CD14, CD40, MICA, IL1A, IL1B, IL1RN
20	fatty liver disease	31.5	RBP4, SERPINE1, NAMPT, LEP, LEPR, INS
21	high blood pressure	31.5	REN, BGLAP, LEP, INS, ALB, PTH
22	hypoglycemia	31.5	PIK3CG, GCK, GCG, VEGFA, SCT, LEP
23	addison's disease	31.3	PDCD1, REN, VDR, BGLAP, CD79A, CD274
24	short stature	31.2	REN, VDR, BGLAP, LEP, MMP9, FLNB
25	paralysis	31.2	PIK3C2A, BCHE, CD274, MIF, INS, IL10
26	multiple endocrine neoplasia	31.1	GCG, SCT, INS, IGFBP3, IGF1, GH1
27	morbid obesity	30.9	GCG, LEP, LEPR, INS, GHRL, LSL
28	rabson-mendenhall syndrome	30.9	LEP, INS, INSR, IGFBP3, IGF1, GH1
29	hyperinsulinism	30.9	GCK, GCG, SELE, SERPINE1, VCAM1, LEP
30	diabetic ketoacidosis	30.8	PIK3C2A, VWF, BGLAP, INS, IL10, IL18
31	glucose intolerance	30.8	GCG, CD79A, MLN, APOA4, APOB, GHRL
32	periodontitis	30.8	VDR, CD14, MMP9, IL10, IL1A, IL1B
33	craniopharyngioma	30.7	LEP, INS, IL1A, IL6, IGF1, ICAM1
34	alcoholic liver cirrhosis	30.7	GSTM1, IL8, ALB, ALDH2, CAT, LSL
35	eating disorder	30.7	GCG, BGLAP, LEP, LEPR, INS, IL1B
36	prader-willi syndrome	30.6	GCG, LEP, LEPR, INS, IL18, IGFBP1
37	insulinoma	30.6	PIK3CG, GCK, GCG, BTC, PAX4, KCNA3
38	hypothyroidism	30.5	LEP, APOB, IGFBP3, IFNA2, IFNB1, GHRL
39	familial combined hyperlipidemia	30.5	LEPR, INS, APOA1, APOA4, APOB, APOE
40	gigantism	30.4	VDR, INS, FGA, IL12B, IL6, APOA1
41	peripheral vascular disease	30.3	VWF, SELE, SELP, SERPINE1, VCAM1, APOA1
42	diabetes insipidus	30.2	REN, VWF, INS, IGF1, TPO, CRH
43	celiac disease	30.2	KIR3DL1, SELE, SELL, VDR, BGLAP, SCT
44	acanthosis nigricans	30.2	LEP, INS, INSR, IGF1, GH1, SHBG
45	congestive heart failure	29.8	PIK3C2A, PIK3CG, REN, XDH, CD40, AOC3
46	growth disorders	29.7	IGFBP1, IGF2, IGFBP2, IGFBP3, IGF1, GH1
47	orthostatic hypotension	29.6	REN, MLN, ALB, SST, ACE, G6PD
48	glucagonoma	29.5	GCG, SCT, INS, INSR, ENO2, GH1
49	lipodystrophy	29.5	RBP4, SERPINE1, NAMPT, LEP, ITGAM, INS
50	hyperinsulinemic hypoglycemia	29.5	GCK, GCG, INS, INSR, ENO2, IGF2

Clinical features from OMIM: 222100

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 chromium picolinate, insulin, insulin,aspart protamine, insulin,aspart,human/rdna, insulin,detemir,human, insulin,glargine,human/rdna, insulin,glulisine,human, insulin,lente,beef, insulin,lente,beef/pork, insulin,lente,beef/purified, insulin,lente,human/rdna, insulin,lente,human/semisynthetic, insulin,lente,pork/purified, insulin,lispro,human/rdna, insulin,lispro,protamine/rdna, insulin,nph,beef, insulin,nph,beef/pork, insulin,nph,beef/purified, insulin,nph,human/rdna, insulin,nph,human/semisynthetic, insulin,nph,pork/purified, insulin,protamine zinc,beef/pork, insulin,protamine zinc,beef/purified, insulin,protamine zinc,pork/purified, insulin,regular,beef/pork, insulin,regular,beef/purified, insulin,regular,human buffered, insulin,regular,human/rdna, insulin,regular,human/semisynthetic, insulin,regular,pork, insulin,regular,pork/purified, insulin,semilente,beef, insulin,semilente,beef/pork, insulin,semilente,pork/purified, insulin,ultralente,beef, insulin,ultralente,beef/pork, insulin,ultralente,beef/purified, insulin,ultralente,human, insulin,ultralente,human/rdna, pramlintide

Cell-based therapeutics:

	Pancreatic islets , PMIDs: 22362173
	Endothelial progenitor cells, PMIDs: 22362173
	Pancreatic islets (cadavers), PMIDs: 15983207, 17005949, 10911004
	Pancreatic endoderm/endocrine precursor-like cells, PMIDs: 22623968
	Pancreatic islets , PMIDs: 16768546, 19433788

MalaCards organs/tissues related to type 1 diabetes mellitus:

²²

id	Organ / Tissue -> Anatomical Compartment -> Cell	Relevance
1	Pancreas -> Islets of Langerhans -> Mature Beta Cells	Potential therapeutic candidate, affected by disease

MGI Mouse Phenotypes related to type 1 diabetes mellitus:

²⁵ (show all 28)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system phenotype	MP:0005397	11.6	PDCD1, PDCD1LG2, BTLA, BMP4, LCN2, SBDS
2	craniofacial phenotype	MP:0005382	10.9	LRP5, NAGLU, BMP4, FOXP3, FLNB, IL12B
3	embryogenesis phenotype	MP:0005380	10.6	LRP5, GCLC, SCN5A, SBDS, COMT, G6PD
4	respiratory system phenotype	MP:0005388	10.5	SELL, SELP, LEPR, CD14, INSR, IL12B
5	renal/urinary system phenotype	MP:0005367	10.0	PDCD1, REN, GCK, SELP, NAGLU, BMP4
6	endocrine/exocrine gland phenotype	MP:0005379	9.9	LRP5, SELL, XDH, CD40LG, IL2, IFNG
7	no phenotypic analysis	MP:0003012	9.9	PDCD1LG2, VEGFA, VCAM1, BMP4, LEPR, MTHFR
8	immune system phenotype	MP:0005387	9.7	LRP5, REN, VWF, BTLA, SELL, SELP
9	nervous system phenotype	MP:0003631	9.4	LRP5, PDCD1, REN, VWF, SELP, NAGLU
10	other phenotype	MP:0005395	9.2	LEPR, CD40LG, IL2, APOA4, APOE, ENPP1
11	hearing/vestibular/ear phenotype	MP:0005377	9.2	NAGLU, VDR, BMP2, BMP4, BMP7, KCNMA1
12	skeleton phenotype	MP:0005390	9.1	PIK3CG, BTC, NAGLU, VEGFA, VDR, BMP2
13	normal phenotype	MP:0002873	9.1	LRP5, REN, GCLC, BTC, RBP4, SELE
14	growth/size phenotype	MP:0005378	8.6	PIK3C2A, PIK3CG, REN, GCK, GCG, GCLC
15	limbs/digits/tail phenotype	MP:0005371	8.6	LRP5, VEGFA, VDR, BMP2, BMP4, BMP7
16	integument phenotype	MP:0010771	8.5	PIK3CG, SELP, LEPR, XDH, CD274, FOXP3
17	liver/biliary system phenotype	MP:0005370	8.2	LRP5, GCK, GCLC, VEGFA, BMP4, SBDS
18	adipose tissue phenotype	MP:0005375	7.9	PIK3C2A, SERPINE1, LEP, LEPR, XDH, CD14
19	digestive/alimentary phenotype	MP:0005381	7.3	VWF, GCG, VEGFA, VDR, BMP2, BMP4
20	reproductive system phenotype	MP:0005389	7.0	REN, RBP4, VEGFA, VDR, BMP2, BMP7
21	behavior/neurological phenotype	MP:0005386	6.5	LRP5, REN, SELE, SELP, NAGLU, BMP4
22	mortality/aging	MP:0010768	6.2	PIK3C2A, LRP5, PDCD1, PDCD1LG2, REN, VWF
23	homeostasis/metabolism phenotype	MP:0005376	5.8	PIK3C2A, PIK3CG, LRP5, PDCD1LG2, REN, VWF
24	muscle phenotype	MP:0005369	5.7	PIK3CG, PDCD1, REN, BTC, RBP4, VEGFA
25	tumorigenesis	MP:0002006	5.7	PDCD1LG2, SELL, SERPINE1, LEP, LEPR, MMP2
26	vision/eye phenotype	MP:0005391	5.7	LRP5, PDCD1, RBP4, SELE, SELP, NAGLU
27	cellular phenotype	MP:0005384	4.6	PIK3CG, LRP5, PDCD1, PDCD1LG2, VWF, GCLC
28	cardiovascular system phenotype	MP:0005385	3.3	PIK3CG, LRP5, PDCD1, REN, VWF, BTC

Articles related to type 1 diabetes mellitus:

(show top 50)    (show all 474)

id	Title	Authors	Year	Affiliating Genes
1	Outcome differences in pediatric patients with type 1 diabetes mellitus depending on their HLA-DQ genotypes. (20138312)	GarcA-a Cabezas M.A.... Benito LA^pez P.	2010	HLA-DQA1, HLA-DQB1
2	Effects of prior intensive insulin therapy on cardiac autonomic nervous system function in type 1 diabetes mellitus: the Diabetes Co ntrol and Complications Trial/Epidemiology of Diabetes Interventions and Compli cations study (DCCT/EDIC). (19470886)	Pop-Busui R.... Herman W.H.	2009	INS
3	Specificity of islet cell autoantibodies and coexiste nce with other organ specific autoantibodies in type 1 diabetes mellitus. (19217947)	Tsirogianni A.... Soufleros K.	2009	PTPRN
4	Increased circulating IL-8 is associated with reduced IGF-1 and related to poor metabolic control in adolescents with type 1 diabete s mellitus. (19773182)	Van Sickle B.J.... Spagnoli A.	2009	IGF1, IL8
5	Insulin is a stronger inducer of insulin resistance t han hyperglycemia in mice with type 1 diabetes mellitus (T1DM). (19654321)	Liu H.Y.... Cao W.	2009	INS
6	Specific association of type 1 diabetes mellitus with anti-cyclic citrullinated peptide-positive rheumatoid arthritis. (19248096)	Liao K.P.... Alfredsson L.	2009	PTPN22
7	Study of interleukin-10 promoter region polymorphisms (-1082A/G, -819T/C and -592A/C) in type 1 diabetes mellitus in Turkish populat ion. (19700864)	Mohebbatikaljahi H.... Demirci H.	2009	IL10
8	Coagulation and fibrinolysis variables in pregnant women with type 1 diabetes mellitus. (18971874)	Bronisz A.... Junik R.	2008	SERPINE1
9	Insulin glargine versus intermediate-acting insulin as the basal component of multiple daily injection regimens for adolescents with type 1 diabetes mellitus. (18589448)	Chase H.P.... Tamborlane W.V.	2008	INS
10	Use of oral glucose minimal model-derived index of insulin sensitivity in subjects with early type 1 diabetes mellitus. (18328342)	Krudys K.M.... Vicini P.	2008	INS
11	Abrupt onset of type 1 diabetes mellitus during recombinant interferon-alpha 2b therapy in a patient with chronic hepatitis B. (18698691)	Lv Y.Y.... Guo H.	2008	IFNA2
12	Use of ABC typing to redefine subtypes of acute-onset type 1 diabetes mellitus: study of 308 patients (18756979)	Zhang C.... Yang X.L.	2008	HLA-DQA1, HLA-DQB1
13	Triple diabetes: coexistence of type 1 diabetes mellitus and a novel mutation in the gene responsible for MODY3 in an overweight adolescent. (18221440)	Bowden S.A.... Hoffman R.P.	2008	HNF1A
14	Role of vascular endothelial growth factor in the development of diabetic retinopathy in patients with type 1 diabetes mellitus (18318205)	Ermakova N.A.... Krasnova L.B.	2008	VEGFA
15	Incidence of thyroid autoimmunity in children with type 1 diabetes mellitus (18292034)	KAPrner A.... AratA^ A.	2008	TG
16	Immunogenetics of HLA class II in Israeli patients with adult-onset type 1 diabetes mellitus. (17584585)	Hirsch D.... Singer J.	2007	HLA-DQB1, HLA-DRB1
17	Glycaemic control and hypoglycaemia in children, adolescents and young adults with unstable type 1 diabetes mellitus treated with insulin glargine or intermediate-acting insulin. (17550216)	Herwig J.... BAPhles H.	2007	INS
18	Case of fulminant type 1 diabetes mellitus complicated with acute renal failure treated with continuous hemodiafiltration (17315734)	Fujinaga A.... Fukusaki M.	2007	PIK3C2A
19	Relationship between autoantibodies and HLA-DQ genotypes in patients with type 1 diabetes mellitus (18036312)	Wang J.P.... Zhou Z.G.	2007	HLA-DQA1, HLA-DQB1
20	The effect of magnesium deficit on serum immunoglobulin concentrations in type 1 diabetes mellitus. (17236288)	Cojocaru M.... FarcaA9iu E.	2006	CD79A
21	Lower bone mineral content in children with type 1 diabetes mellitus is linked to female sex, low insulin-like growth factor type I levels, and high insulin requirement. (16849406)	LAcger J.... Czernichow P.	2006	IGF1
22	Glycaemic control, markers of endothelial cell activation and oxidative stress in children with type 1 diabetes mellitus. (16442660)	Seckin D.... Ertugrul S.	2006	ICAM1, APOB
23	Investigation of KIR gene frequencies in type 1 diabetes mellitus. (17174747)	Middleton D.... Tuomilehto-Wolf E.	2006	KIR3DL1, KIR2DS5
24	IL-15 is elevated in serum patients with type 1 diabetes mellitus. (16098919)	Kuczynski S.... Dworacka M.	2005	IL15
25	Immune modulation for prevention of type 1 diabetes mellitus. (15734555)	Raz I.... Naparstek Y.	2005	GAD1
26	Interleukin-6 (IL-6) and IGF-IGFBP system in children and adolescents with type 1 diabetes mellitus. (15372363)	Wedrychowicz A.... Wedrychowicz A.	2004	IL6
27	Association study of human MTH1 gene polymorphisms with type 1 diabetes mellitus. (15516784)	Miyako K.... Hara T.	2004	NUDT1
28	Oral modified insulin (HIM2) in patients with type 1 diabetes mellitus: results from a phase I/II clinical trial. (14681842)	Clement S.... Kosutic G.	2004	INS
29	Pubertal changes in serum leptin levels in adolescents with type 1 diabetes mellitus: a controlled longitudinal study. (15645699)	Myers S.E.... Mooradian A.D.	2004	LEP, LSL
30	A transmembrane protein-tyrosine phosphatase receptor type C (CD45) exon A point mutation (77 C to G) is not associated with the development of type 1 diabetes mellitus in a German population. (15548260)	Thude H.... Barz D.	2004	PTPRC
31	Role of phosphatidylinositol 3-kinase in platelet aggregation in type 1 diabetes mellitus (16100904)	Sybirna N.O.... VelykyA- M.M.	2004	PIK3CG
32	The effects of smoking and its cessation on 8-epi-PGF 2alpha and transforming growth factor-beta 1 in Type 1 diabetes mellitus. (15008841)	Flores L.... Esmatjes E.	2004	TGFB1
33	Anti-GAD-positive patients with type 1 diabetes mellitus have higher prevalence of autoimmune thyroiditis than anti-GAD-negative patients with type 1 and type 2 diabetes mellitus. (15209535)	BA!rovA! H.... Masek Z.	2004	TPO
34	Aldehyde dehydrogenase 2 genotype in type 1 diabetes mellitus. (12706323)	Suzuki Y.... Matsuoka K.	2003	ALDH2
35	Alleles of diabetes-resistant BN rats contribute to i nsulin-dependent type 1 diabetes mellitus. (12657525)	KlAPting I.... RadoviA8 B.	2003	IDDM2
36	Antibodies to heat-shock protein 65 and neopterin levels in patients with type 1 diabetes mellitus. (12784185)	Weitgasser R.... Hoppichler F.	2003	HSPD1
37	Cell-mediated immune responses to GAD and beta-casein in type 1 diabetes mellitus in Thailand. (11850100)	Banchuin N.... Pasurakul T.	2002	CSN2
38	Double-stranded RNA cooperates with interferon-gamma and IL-1 beta to induce both chemokine expression and nuclear factor-kappa B-dependent apoptosis in pancreatic beta-cells: potential mechanisms for viral-induced insulitis and beta-cell death in type 1 diabetes mellitus. (11897677)	Liu D.... Eizirik D.L.	2002	IL1B, FAS, IL15
39	Vitamin A, retinol binding protein and lipids in type 1 diabetes mellitus. (11840179)	Baena R.M.... Molina-Font J.A.	2002	RBP4
40	CD45 exon 4 point mutation does not confer susceptibility to type 1 diabetes mellitus or Graves' disease. (11841494)	Wood J.P.... Badenhoop K.	2002	PTPRC
41	Association of polymorphism of methylene-tetrahydro-folate-reductase with urinary albumin excretion rate in type 1 diabetes mellitus but not with preeclampsia, retinopathy, and preterm delivery. (11531629)	Lauszus F.F.... Klebe J.G.	2001	ALB, MTHFR
42	Improvement of HbA1c without increased hypoglycemia i n adolescents and young adults with type 1 diabetes mellitus treated with recom binant human insulin-like growth factor-I and insulin. rhIGF-I in IDDM Study Gr oup. (11308044)	Quattrin T.... Martha P.	2001	IGF1
43	Evaluation of salivary sialic acid level and Cu-Zn superoxide dismutase activity in type 1 diabetes mellitus. (11249151)	Belce A.... Seymen H.O.	2000	SOD1
44	Latent autoimmune (Type-1) diabetes mellitus in adults. Part. I. Serologic markers of autoimmune involvement of pancreatic beta-cells: GADA, ICA, IA-2 a IA-A (15641228)	Martinka E.... Mokan M.	1999	PTPRN
45	Association of CTLA-4 polymorphism with positive anti-GAD antibody in Japanese subjects with type 1 diabetes mellitus. (10619986)	Hayashi H.... Ishikawa S.E.	1999	CTLA4
46	The combination of antibodies to GAD-65 and IA-2ic can replace the islet-cell antibody assay to identify subjects at risk of type 1 diabetes mellitus. (10596966)	Hatziagelaki E.... Bretzel R.G.	1999	GAD2
47	High serum leptin levels in children with type 1 diabetes mellitus: contribution of age, BMI, pubertal development and metabolic status. (10594521)	Luna R.... Casanueva F.F.	1999	LEP, LSL
48	Importance of short-term administration of low doses of somatostatin analog in the development and remission of type 1 diabetes mellitus in adult patients (9820108)	DvorA!kovA! H.... Zamrazil V.	1998	SST
49	Apolipoprotein (a) levels in patients with type 1 diabetes mellitus are unrelated to metabolic control or vascular disease. (7856176)	KnAPbl P.... Schernthaner G.	1994	APOB
50	Increased urinary excretion of transferrin in children with type 1 diabetes mellitus. (1688749)	Martin P.... Stickland M.H.	1990	TF, ALB, AMBP

Genes related to type 1 diabetes mellitus according to GeneCards:

(show top 50)    (show all 238)

id	Symbol	Description	Score	GeneCards Section Context
1	LRP5	low density lipoprotein receptor-related protein 5	11.1	Summaries
2	SLC25A5P3	solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 pseudogene 3	11.0	Publications
3	IDDM2	insulin-dependent diabetes mellitus 2	11.0	Publications
4	PTPRN	protein tyrosine phosphatase, receptor type, N	11.0	Publications
5	PAX4	paired box 4	11.0	Publications
6	MIOX	myo-inositol oxygenase	11.0	Publications
7	KIR2DS5	killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 5	11.0	Publications
8	GAD1	glutamate decarboxylase 1 (brain, 67kDa)	11.0	Publications
9	KIR2DL2	killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 2	11.0	Publications
10	SIAE	sialic acid acetylesterase	11.0	Publications
11	HLA-DQA1	major histocompatibility complex, class II, DQ alpha 1	11.0	Publications
12	HLA-DQB1	major histocompatibility complex, class II, DQ beta 1	11.0	Publications
13	SBDS	Shwachman-Bodian-Diamond syndrome	11.0	Publications
14	KIR2DS2	killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 2	11.0	Publications
15	KCNA3	potassium voltage-gated channel, shaker-related subfamily, member 3	11.0	Publications
16	NAGA	N-acetylgalactosaminidase, alpha-	11.0	Publications
17	GAD2	glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)	11.0	Publications
18	ADPGK	ADP-dependent glucokinase	11.0	Publications
19	G6PC2	glucose-6-phosphatase, catalytic, 2	11.0	Publications
20	MLNR	motilin receptor	11.0	Publications
21	CLEC3B	C-type lectin domain family 3, member B	11.0	Publications
22	CSN2	casein beta	11.0	Publications
23	CYP27B1	cytochrome P450, family 27, subfamily B, polypeptide 1	11.0	Publications
24	IAPP	islet amyloid polypeptide	11.0	Publications
25	HYAL1	hyaluronoglucosaminidase 1	11.0	Publications
26	CELA3B	chymotrypsin-like elastase family, member 3B	11.0	Publications
27	SOX2	SRY (sex determining region Y)-box 2	11.0	Publications
28	LSL	Leptin, serum levels of	11.0	Publications
29	HLA-DMA	major histocompatibility complex, class II, DM alpha	11.0	Publications
30	HLA-DMB	major histocompatibility complex, class II, DM beta	11.0	Publications
31	HLA-DRB3	major histocompatibility complex, class II, DR beta 3	11.0	Publications
32	BTLA	B and T lymphocyte associated	11.0	Publications
33	KIR3DS1	killer cell immunoglobulin-like receptor, three domains, short cytoplasmic tail, 1	11.0	Publications
34	TNFRSF25	tumor necrosis factor receptor superfamily, member 25	11.0	Publications
35	KLRB1	killer cell lectin-like receptor subfamily B, member 1	11.0	Publications
36	PHOX2B	paired-like homeobox 2b	11.0	Publications
37	AMBP	alpha-1-microglobulin/bikunin precursor	11.0	Publications
38	MICA	MHC class I polypeptide-related sequence A	11.0	Publications
39	AKR1B1	aldo-keto reductase family 1, member B1 (aldose reductase)	11.0	Publications
40	NEUROD1	neuronal differentiation 1	11.0	Publications
41	NUDT1	nudix (nucleoside diphosphate linked moiety X)-type motif 1	11.0	Publications
42	MLN	motilin	11.0	Publications
43	PDCD1	programmed cell death 1	11.0	Publications
44	CTLA4	cytotoxic T-lymphocyte-associated protein 4	11.0	Publications
45	PTPN3	protein tyrosine phosphatase, non-receptor type 3	11.0	Publications
46	NAGLU	N-acetylglucosaminidase, alpha	11.0	Publications
47	PDCD1LG2	programmed cell death 1 ligand 2	11.0	Publications
48	FBP2	fructose-1,6-bisphosphatase 2	11.0	Publications
49	SLC25A4	solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4	11.0	Publications
50	SLC11A1	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	11.0	Publications

Pathways related to type 1 diabetes mellitus according to GeneDecks:

(show top 50)    (show all 132)

id	Pathway	Score	Top Affiliating Genes
1	Antigen processing and presentation20	11.5	KIR2DS5, KIR3DL1, KIR2DL2, HLA-DMA, HLA-DMB, HLA-DPB1
2	Cell adhesion molecules (CAMs)20	11.0	PDCD1LG2, SELL, SELP, CD40, ITGAM, HLA-DMA
3	Graft-versus-host disease20	10.8	KIR3DL1, KIR2DL2, IL1A, IL2, HLA-DMA, HLA-DMB
4	Staphylococcus aureus infection20	10.7	SELP, ITGAM, IL10, ICAM1, HLA-DMA, HLA-DMB
5	Immune System38	10.6	PDCD1, PDCD1LG2, KIR2DS5, KIR3DS1, KIR3DL1, KIR2DS2
6	RAR-Gamma-RXR-Alpha Degradation36	10.3	BMP2, BMP4, BMP7, IL15, IL2, CCL11
7	Asthma20	10.2	CD40LG, CD40, IL10, IL4, CCL11, HLA-DMA
8	NFAT in Immune Response36	10.2	BTC, BMP2, BMP4, BMP7, CD79A, INSR
9	Intestinal immune network for IgA production20	10.0	CD40LG, CD40, IL10, IL15, IL2, IL4
10	Molecular Mechanisms of Cancer36	9.8	PIK3CG, LRP5, BMP2, BMP4, BMP7, ITGAM
11	Autoimmune thyroid disease20	9.8	CD40LG, CD40, IL10, IL2, IL4, FAS
12	Toxoplasmosis20	9.6	PIK3CG, CD40LG, CD40, IL10, IL12B, CCR5
13	Apoptotic Pathways in Synovial Fibroblasts36	9.6	BTC, BMP2, BMP4, BMP7, IL2, IL2RA
14	Amoebiasis20	9.5	CD14, ITGAM, IL12B, IL1B, IL1R1, IL6
15	Type I diabetes mellitus20	9.5	INS, IL12B, IL1A, IL1B, IL2, FAS
16	ERK Signaling36	9.4	BTC, BMP2, BMP4, BMP7, ITGAM, INSR
17	NF-KappaB (p50-p65) Pathway36	9.4	BTC, BMP2, BMP4, BMP7, IL1A, IL1B
18	Hematopoietic cell lineage20	9.3	CD14, ITGAM, IL1A, IL1B, IL1R1, IL2RA
19	Endothelin-1 Signaling Pathway36	9.3	BMP2, BMP4, BMP7, INSR, IL10, IL12B
20	NF-KappaB Family Pathway36	9.2	BTC, BMP2, BMP4, BMP7, IL1A, IL1B
21	THC Differentiation Pathway36	9.2	IL10, IL12B, IL18, IL2, IL2RA, IL4
22	Leishmaniasis20	9.2	ITGAM, IL10, IL12B, IL1A, IL1B, IL4
23	Tuberculosis20	9.1	VDR, CD14, ITGAM, IL10, IL12B, IL18
24	IL-6 Pathway36	9.1	BMP2, BMP4, BMP7, IL10, IL12B, IL18
25	PGC1Alpha Pathway36	9.1	BMP2, BMP4, BMP7, INSR, IL12B, IL15
26	Transcription Role of VDR in regulation of genes involved in osteoporosis10	9.1	VDR, BGLAP, AR, IL1A, IL1B, IL6
27	Transcription_Role of VDR in regulation of genes involved in osteoporosis41	9.0	VDR, BGLAP, AR, IL1A, IL1B, IL6
28	African trypanosomiasis20	8.9	SELE, VCAM1, IL10, IL12B, IL18, IL1B
29	Allograft rejection20	8.8	CD40LG, CD40, IL10, IL12B, IL2, IL4
30	Akt Signaling36	8.7	PIK3CG, BTC, BMP2, BMP4, BMP7, ITGAM
31	Influenza A20	8.2	PIK3CG, IL12B, IL18, IL1A, IL1B, IL6
32	Rheumatoid arthritis20	8.1	VEGFA, IL15, IL18, IL1A, IL1B, IL6
33	Rho Family GTPases36	8.1	BTC, BMP2, BMP4, BMP7, ITGAM, INSR
34	all-trans-Retinoic Acid Signaling in Brain36	8.1	BMP2, BMP4, BMP7, IL10, IL12B, IL15
35	Tec Kinases Signaling36	8.1	BTC, BMP2, BMP4, BMP7, ITGAM, INSR
36	Malaria20	8.1	SELE, SELP, VCAM1, CD40LG, CD40, GYPB
37	PEDF Induced Signaling36	8.0	BMP2, BMP4, BMP7, IL10, IL12B, IL15
38	MIF Mediated Glucocorticoid Regulation36	8.0	BMP2, BMP4, BMP7, CD14, MIF, IL10
39	MIF Regulation of Innate Immune Cells36	8.0	BMP2, BMP4, BMP7, CD14, MIF, IL10
40	TGF-Beta Pathway36	7.9	BTC, BMP2, BMP4, BMP7, IL10, IL12B
41	PAK Pathway36	7.9	BTC, BMP2, BMP4, BMP7, IL10, IL12B
42	STAT3 Pathway36	7.8	BMP2, BMP4, BMP7, IL10, IL12B, IL15
43	MAPK Family Pathway36	7.8	BTC, BMP2, BMP4, BMP7, IL10, IL12B
44	Antioxidant Action of Vitamin-C36	7.7	BTC, BMP2, BMP4, BMP7, FLNB, IL10
45	SOCS Pathway36	7.7	BMP2, BMP4, BMP7, INS, INSR, IL10
46	Cytokine Network36	7.6	IL10, IL12B, IL15, IL18, IL1A, IL1B
47	p38 Signaling36	7.3	BTC, BMP2, BMP4, BMP7, INSR, IL10
48	Chagas disease (American trypanosomiasis)20	7.0	PIK3CG, SERPINE1, IL10, IL12B, IL1B, IL2
49	JAK-STAT Pathway36	6.6	BTC, BMP2, BMP4, BMP7, INSR, IL10
50	Cytokine-cytokine receptor interaction20	5.7	VEGFA, BMP2, BMP7, LEP, LEPR, CD40LG

Compounds related to type 1 diabetes mellitus according to GeneDecks:

(show top 50)    (show all 511)

id	Compound	Score	Top Affiliating Genes
1	sialic acid32	11.0	RBP4, SELL, NAGLU, LPO, CD79A, GYPB
2	gold32	10.8	PIK3C2A, RBP4, NAGLU, BMP7, SCT, LCN2
3	triiodothyronine32	10.7	PIK3C2A, RBP4, LEP, LEPR, IGFBP1, IGF2
4	budesonide32 42 9 9	13.6	BGLAP, CCL11, CSF2
5	androstenedione32 18	11.6	REN, RBP4, LEP, LEPR, AR, INS
6	ethanol32 34 9 18 9	14.5	GCLC, BMP7, BCHE, KCNMA1, SCT, LEPR
7	acipimox32	10.4	GCG, LEP, INS, APOA1, APOB, IGF1
8	citrate32	10.3	PIK3C2A, GCK, SELP, NAGLU, VDR, CD79A
9	methimazole32 9 9	12.3	VWF, SELE, SELL, LPO, BGLAP, GSR
10	ionomycin32	10.2	CLIP1, KCNMA1, CD274, CD40, CCL11, CCL3
11	ramipril32 9 9	12.1	REN, SERPINE1, BCHE, CD79A, INS, ALB
12	agarose32	10.1	VWF, BMP7, GSTM1, GSTT1, IL1RN, APOA4
13	kininogen32	9.8	REN, VWF, SELP, SERPINE1, CLEC3B, APOA1
14	dopamine32 9 18 9	12.7	REN, GCG, RBP4, SELE, NAGLU, BMP2
15	pioglitazone32 9 9	11.6	GCG, RBP4, NAMPT, VEGFA, VCAM1, LEP
16	ibmx32	9.5	GCG, VCAM1, BMP2, SCT, MMP2, INS
17	hydrochlorothiazide32 34 9 18 9	13.5	REN, SERPINE1, VDR, BGLAP, KCNMA1, APOA1
18	forskolin32 42 9 9	12.5	REN, GCK, GCG, BMP2, BMP4, KCNMA1
19	phenylephrine32 9 18 9	12.4	KCNMA1, LEP, AR, APOB, NGF, AGT
20	perindopril32 34 9 9	12.4	REN, VWF, SERPINE1, NAGLU, VEGFA, BCHE
21	rituximab32 34 9 9	12.3	CD79A, CD40LG, CD40, IL10, IL15, IL1R1
22	n acetylcysteine32	9.2	VWF, GCLC, SELE, SELP, NAGLU, VCAM1
23	dihydrotestosterone32 9 18 9	12.1	SERPINE1, VDR, BMP2, BGLAP, LEP, CD79A
24	tuberculin32	9.0	CD79A, CD14, CD40LG, MIF, IL10, IL15
25	pravastatin32 34 9 18 9	12.9	PIK3C2A, SELE, SELP, SERPINE1, BMP2, BCHE
26	quercetin32 42 9 18 9	12.9	PIK3C2A, PIK3CG, SELE, LPO, VCAM1, XDH
27	nifedipine32 9 9	10.8	PIK3CG, REN, GCG, SELE, SERPINE1, NAGLU
28	wortmannin32 42	9.6	PIK3C2A, PIK3CG, GCG, BTC, VCAM1, BMP2
29	sulfasalazine32 9 9	10.6	SELE, MTHFR, CD79A, CD40LG, IL12B, IL1A
30	polysaccharide32	8.5	SELE, SELL, SELP, VCAM1, BMP2, CLEC3B
31	ibuprofen32 9 18 9	11.5	VCAM1, LEP, MMP2, IL10, IL1B, IL1R1
32	estrogen32	8.3	LRP5, VWF, GCG, RBP4, SERPINE1, VDR
33	homocysteine32 18	9.3	PIK3C2A, VWF, SELE, SELP, SERPINE1, NAGLU
34	butyrate32	8.2	GCK, GCG, VDR, BCHE, LEP, CD14
35	tgf beta132	8.1	SERPINE1, VCAM1, BMP7, MMP2, FOXP3, IL10
36	adenylate32	7.9	PIK3CG, VWF, GCK, GCG, RBP4, SELE
37	methotrexate32 34 42 9 9	11.8	PIK3C2A, SELE, SERPINE1, NAGLU, LEP, MTHFR
38	lipid32	7.7	PIK3C2A, PIK3CG, LRP5, KIR3DL1, GCK, GCG
39	sb 20358032 42	8.4	GCG, SELE, VEGFA, VDR, VCAM1, BMP2
40	ribavirin32 34 9 9	10.4	LEP, CD40LG, MMP2, MMP9, IL10, IL18
41	infliximab32 9 9	9.2	SELE, VEGFA, BGLAP, IL10, IL15, IL18
42	5fluorouracil32	6.9	PIK3CG, GCG, SELE, VEGFA, VDR, MTHFR
43	lactate32	6.9	PIK3C2A, VWF, GCK, GCG, RBP4, SELE
44	nitric oxide32 9 18 9	9.8	REN, GCK, SELE, SELP, NAGLU, LPO
45	paraffin32	6.8	VWF, SELL, VEGFA, VCAM1, BGLAP, LEP
46	gm-csf32	6.6	VEGFA, CD14, IL10, IL15, IL18, IL1A
47	atorvastatin32 34 9 18 9	10.5	PIK3C2A, VWF, SELE, SELL, SELP, SERPINE1
48	simvastatin32 34 42 9 18 9	10.0	PIK3C2A, VWF, RBP4, SELE, SELL, SELP
49	genistein32 9 18 9	7.7	PIK3CG, GCG, SELE, SELL, SELP, SERPINE1
50	actinomycin d32	3.5	PIK3CG, SELE, SERPINE1, VEGFA, VDR, BMP2

Cellular components related to type 1 diabetes mellitus according to GeneDecks:

(show all 13)

id	Name	GO ID	Score	Top Affiliating Genes
1	MHC class II protein complex	GO:042613	11.0	HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DRA, HLA-DQB1, HLA-DQA1
2	ER to Golgi transport vesicle membrane	GO:012507	10.8	HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DRA, HLA-DQB1, HLA-DQA1
3	integral to lumenal side of endoplasmic reticulum membrane	GO:071556	10.7	HLA-E, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DRA, HLA-DQB1
4	clathrin-coated endocytic vesicle membrane	GO:030669	10.7	HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DRA, HLA-DQB1, HLA-DQA1
5	integral to plasma membrane	GO:005887	10.6	TNF, TPO, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DRA
6	transport vesicle membrane	GO:030658	10.4	SLC30A8, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DRA, HLA-DQB1
7	secretory granule	GO:030141	10.2	GHRL, CYBA, PLAT, TF, SLC30A8, HSPD1
8	cell surface	GO:009986	9.8	HSPD1, GHSR, TPO, TNF, PLAT, PLAU
9	platelet alpha granule lumen	GO:031093	9.4	TIMP1, TGFB1, TGFB2, KNG1, HGF, PF4
10	external side of plasma membrane	GO:009897	8.7	ADA, CD79A, VCAM1, SELP, SELL, BTLA
11	plasma membrane	GO:005886	8.3	APOE, KCNMA1, KCNA3, VCAM1, SERPINE1, SELP
12	extracellular region	GO:005576	4.7	ACE2, GH1, HP, ALB, IAPP, F5
13	extracellular space	GO:005615	4.1	HGF, EDN1, PF4, NGF, PLAU, PLAT

Biological processes related to type 1 diabetes mellitus according to GeneDecks:

(show top 50)    (show all 70)

id	Name	GO ID	Score	Top Affiliating Genes
1	T cell costimulation	GO:031295	11.3	HLA-DRB3, HLA-DRB4, HLA-DQA1, CD274, HLA-DQB1, CTLA4
2	glucose homeostasis	GO:042593	10.6	NEUROD1, GCK, RBP4, SERPINE1, INS, G6PC2
3	negative regulation of T cell proliferation	GO:042130	10.5	HLA-DRB1, HLA-DRB3, HLA-DRB4, TGFB1, IL10, CD274
4	response to vitamin D	GO:033280	10.5	TGFB1, CXCL10, TGFB2, SPP1, CYP27B1, IL1B
5	positive regulation of gene expression	GO:010628	10.4	VEGFA, TGFB1, VDR, BMP2, IL18, CTGF
6	regulation of immune response	GO:050776	10.4	CD40, SMAD3, ICAM1, IL4, CD96, VCAM1
7	response to estradiol stimulus	GO:032355	10.2	TGFB1, NOS3, CTGF, GH1, IGFBP2, IL1B
8	positive regulation of interferon-gamma production	GO:032729	10.2	TLR4, CD40LG, IL12B, IL18, IL1B, IL2
9	positive regulation of mitosis	GO:045840	10.2	EDN1, TNF, LRP5, IGF1, IGF2, IL1B
10	positive regulation of MAPK cascade	GO:043410	10.2	INS, ADRB2, SOX2, AGT, IGF1, IGFBP3
11	interferon-gamma-mediated signaling pathway	GO:060333	10.2	HLA-DQB1, HLA-E, HLA-DQA1, HLA-DPB1, HLA-DRB3, ICAM1
12	B cell proliferation	GO:042100	10.2	CD79A, CD40LG, CD40, IL10, IFNB1, HSPD1
13	small molecule metabolic process	GO:044281	10.1	G6PD, G6PC2, PSMB8, ACLY, COMT, NOS3
14	positive regulation of inflammatory response	GO:050729	10.0	IL12B, IL15, IL2, CCR2, CCL3, PLA2G7
15	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	10.0	IL6, IGF2, MIF, VEGFA, INS, TLR4
16	negative regulation of inflammatory response	GO:050728	10.0	GHSR, TNFRSF1B, ADRB2, ADA, ADIPOQ, GHRL
17	female pregnancy	GO:007565	10.0	IL1RN, AMBP, LEP, IL4, NPPA, TGFB2
18	immune response	GO:006955	9.9	CSF2, CXCL10, TLR4, IL8, IL4, IL2RA
19	defense response to Gram-negative bacterium	GO:050829	9.9	IL12B, SERPINE1, SELP, NOS2, IL6, TLR4
20	response to lipopolysaccharide	GO:032496	9.9	TLR4, EDN1, NGF, CXCL10, MMP9, CYP27B1
21	cellular response to organic cyclic compound	GO:071407	9.7	CCL3, SMAD5, TNF, SMAD1, IL1B, CCL2
22	regulation of insulin secretion	GO:050796	9.7	GCG, GCK, LEP, INS, IL1B, IFNG
23	cell-cell signaling	GO:007267	9.6	SST, CXCL10, TGFB2, AGT, CCL3, EDN1
24	positive regulation of protein phosphorylation	GO:001934	9.6	TGFB1, CD40, BMP4, BMP2, VEGFA, INSR
25	positive regulation of activated T cell proliferation	GO:042104	9.6	IL18, IL12B, IL2, IL4, IGF2, IGFBP2
26	lipopolysaccharide-mediated signaling pathway	GO:031663	9.6	TLR4, TGFB1, IL18, IL1B, CCL2, CCL3
27	positive regulation of nitric oxide biosynthetic process	GO:045429	9.5	TLR4, TLR2, EDN1, INS, INSR, IL1B
28	positive regulation of cell proliferation	GO:008284	9.4	IL2, IL15, INSR, AR, INS, LEP
29	negative regulation of smooth muscle cell proliferation	GO:048662	9.4	ADIPOQ, NPPB, IL15, NOS3, IFNG, IGFBP3
30	negative regulation of cell proliferation	GO:008285	9.3	TNF, TP53, IFNB1, SMAD1, SMAD4, NOS3
31	aging	GO:007568	9.3	IGFBP2, AGT, TIMP1, TGFB1, TGFB2, ADA
32	response to mechanical stimulus	GO:009612	9.3	CCL2, BMP2, BGLAP, MMP9, NGF, IGFBP2
33	cytokine-mediated signaling pathway	GO:019221	9.2	HLA-E, CCL2, CCR2, IL6, IL1B, IL1A
34	platelet degranulation	GO:002576	9.2	VWF, SELP, SERPINE1, VEGFA, FGA, APOA1
35	positive regulation of T cell proliferation	GO:042102	9.1	IL15, IL12B, PDCD1LG2, IL1B, IFNG, PTPRC
36	response to heat	GO:009408	9.1	SST, CD14, GCLC, CCL2, MMP9, MICA
37	platelet activation	GO:030168	8.9	SELP, SOD1, PIK3CG, KNG1, HGF, TF
38	negative regulation of apoptotic process	GO:043066	8.8	CAT, TP53, TNF, SMAD3, PF4, TIMP1
39	cell surface receptor signaling pathway	GO:007166	8.7	PTPRC, IFNG, TNFRSF25, EDN1, SST, CXCL10
40	response to glucocorticoid stimulus	GO:051384	8.6	BCHE, INSR, IL10, IL1B, IL1RN, CCL2
41	neutrophil chemotaxis	GO:030593	8.6	IFNG, SPP1, EDN1, TGFB2, IL1B, PIK3CG
42	response to ethanol	GO:045471	8.5	NOS3, TLR4, SOD1, ADIPOQ, ICAM1, CCL2
43	positive regulation of apoptotic process	GO:043065	8.4	TP53, ADRB2, NEUROD1, MMP9, IGFBP3, TLR4
44	cellular response to lipopolysaccharide	GO:071222	8.1	SERPINE1, NOS2, CCL2, TLR4, CCR5, IFNG
45	anti-apoptosis	GO:006916	8.0	NGF, GPX1, IL1B, TNF, IL10, CD40LG
46	positive regulation of transcription from RNA polymerase II promoter	GO:045944	7.9	ADRB2, IFNG, IFNB1, NEUROD1, IL6, IL4
47	inflammatory response	GO:006954	7.9	PIK3CG, IL10, CD40, CD40LG, CD14, BMP2
48	blood coagulation	GO:007596	7.6	SOD1, IGF1, APOB, APOA1, FGA, ITGAM
49	response to drug	GO:042493	7.4	GAD2, GAD1, NEUROD1, NPPB, SOD1, TGFB1
50	response to hypoxia	GO:001666	6.8	SMAD4, NPPB, ADA, ADIPOQ, SOD3, TGFB2

Molecular functions related to type 1 diabetes mellitus according to GeneDecks:

(show all 10)

id	Name	GO ID	Score	Top Affiliating Genes
1	MHC class II receptor activity	GO:032395	10.4	HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DRA, HLA-DQB1, HLA-DQA1
2	hormone activity	GO:005179	10.3	ADIPOQ, MLN, LEP, SCT, GCG, INS
3	protease binding	GO:002020	9.8	POLG, CST3, C10orf2, TNF, TP53, IL1R1
4	heparin binding	GO:008201	9.5	PTPRC, CTGF, PF4, ABP1, SOD3, KNG1
5	copper ion binding	GO:005507	9.4	SOD1, ABP1, TP53, ALB, F5, AOC3
6	protein homodimerization activity	GO:042803	8.8	ADIPOQ, ADRB2, SLC11A1, SLC30A8, PON1, CSF1
7	growth factor activity	GO:008083	8.7	HGF, CSF2, CSF1, TGFB2, TGFB1, AGT
8	receptor binding	GO:005102	8.5	CRH, NOS2, TGFB2, CXCL10, NPPA, NPPB
9	cytokine activity	GO:005125	7.6	IL6, VEGFA, NAMPT, BMP2, BMP4, IL4
10	protein binding	GO:005515	5.3	ICAM1, APOA1, IL8, IL4, IL1R1, IL1A