IDDM
MCID: TYP008
MIFTS: 77

Type 1 Diabetes Mellitus (IDDM) malady

Summaries for Type 1 Diabetes Mellitus

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8Disease Ontology, 46OMIM, 32MalaCards
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Disease Ontology:8 A diabetes mellitus that results from the body's failure to produce insulin and has material basis in autoimmune destruction of insulin-producing beta cells of the pancreas.

MalaCards: Type 1 Diabetes Mellitus, also known as diabetes mellitus type 1, is related to diabetes mellitus and thyroiditis. An important gene associated with Type 1 Diabetes Mellitus is LRP5 (low density lipoprotein receptor-related protein 5), and among its related pathways are Allograft rejection and Allograft rejection. The drugs insulin and insulin, aspart, human and the compounds glucose and alanine have been mentioned in the context of this disorder. Affiliated tissues include endothelial, bone and thyroid, and related mouse phenotypes are normal and endocrine/exocrine gland.

Description from OMIM:46 222100

Aliases & Classifications for Type 1 Diabetes Mellitus

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8Disease Ontology, 9diseasecard, 42NIH Rare Diseases, 22GTR, 30LifeMap Discovery™, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 46OMIM
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Aliases & Descriptions:

type 1 diabetes mellitus 8 30
diabetes mellitus type 1 42 22
diabetes mellitus, insulin-dependent, susceptibility to 9
diabetes mellitus, insulin dependent 42
diabetes mellitus, insulin-dependent 60
insulin-dependent diabetes mellitus 8
type i diabetes mellitus 8
iddm 8


External Ids:

Disease Ontology8 DOID:9744
MeSH34 D003922
NCIt39 C2986
OMIM46 222100

Related Diseases for Type 1 Diabetes Mellitus

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Type 2 Diabetes Mellitus family:

type 1 diabetes mellitus Diabetes Mellitus

Diseases related to Type 1 Diabetes Mellitus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 301)
idRelated DiseaseScoreTop Affiliating Genes
1diabetes mellitus32.5PTPRN, PAX4, LRP5, INS, AKR1B1, HLA-DQA1
2thyroiditis31.3GAD2, CTLA4
3celiac disease31.2HLA-DQA1, HLA-DQB1
4diabetic retinopathy31.2GAD1, AKR1B1, INS
5hypoglycemia31.1INS, AKR1B1, GAD1, LSL
6autoimmune thyroiditis31.1CTLA4, GAD2, GAD1
7pancreatitis31.1INS
8diabetic ketoacidosis31.1LSL, CTLA4, GAD2, GAD1, INS
9diabetic neuropathy31.1GAD2, GAD1, AKR1B1, INS
10neuropathy31.1AKR1B1, INS
11type 2 diabetes mellitus31.0IDDM2, LSL, GAD2, GAD1, AKR1B1, INS
12graves' disease30.9PTPRN, HLA-DQA1, HLA-DQB1, GAD1, GAD2, CTLA4
13autonomic neuropathy30.9GAD2, GAD1, AKR1B1, INS
14obesity30.9LSL, GAD2, AKR1B1, INS
15diabetic autonomic neuropathy30.9MLNR, AKR1B1
16hyperglycemia30.9LSL, GAD2, GAD1, AKR1B1, INS, PAX4
17hepatitis30.9CTLA4
18type 1 diabetes30.8CSN2, CTLA4, GAD2, GAD1, INS, PTPRN
19dermatitis30.8CTLA4
20glucose intolerance30.7LSL, GAD1, INS
21insulinoma30.5GAD2, GAD1, INS, PAX4, PTPRN
22hypothyroidism30.5LSL, CTLA4, INS
23gastroparesis30.5MLNR, INS
24hypertension30.5INS
25addison's disease30.5CTLA4
26dermatitis herpetiformis30.5HLA-DQB1
27liver cirrhosis30.5LSL
28hyperinsulinism30.5LSL, INS, PAX4
29multiple sclerosis30.4LSL, CSN2, CTLA4, GAD1, HLA-DQB1, HLA-DQA1
30gestational diabetes30.4LSL, GAD1, INS, PTPRN
31hepatitis b30.4AKR1B1, HLA-DQA1, HLA-DQB1
32maturity-onset diabetes of the young30.4PAX4, INS
33proliferative diabetic retinopathy30.4GAD1
34polycystic ovary syndrome30.4INS, LSL
35viral hepatitis30.3HLA-DQA1
36cystic fibrosis30.3HLA-DQA1, INS
37acquired immunodeficiency syndrome30.3KIR2DL2
38rheumatoid arthritis30.2HLA-DQB1, CTLA4
39arthritis30.2CTLA4
40influenza30.2KIR2DL2
41ischemia30.2AKR1B1, GAD1, GAD2
42glomerulonephritis30.2NAGA
43asthma30.2HLA-DQA1, CTLA4
44retinal disease30.2INS, AKR1B1, GAD1
45lymphopenia29.8IDDM2
46diabetic nephropathy10.9
47periodontitis10.6
48diabetic polyneuropathy10.6
49polyneuropathy10.6
50atherosclerosis10.6

Graphical network of the top 20 diseases related to Type 1 Diabetes Mellitus:



Diseases related to type 1 diabetes mellitus

Clinical Features for Type 1 Diabetes Mellitus

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46OMIM
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Clinical features from OMIM:

222100

Drugs & Therapeutics for Type 1 Diabetes Mellitus

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Type 1 Diabetes Mellitus

Drug clinical trials:

Search ClinicalTrials for Type 1 Diabetes Mellitus

Search NIH Clinical Center for Type 1 Diabetes Mellitus

Search CenterWatch for Type 1 Diabetes Mellitus

Inferred drug relations via UMLS60/NDF-RT40:

Show with subtypes

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Type 1 Diabetes Mellitus cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Type 1 Diabetes Mellitus:
Bone marrow-derived adult mesenchymal stem cells for treatment of type I diabetes
Dendritic cells for type I diabetes
DIABECELL
Endothelial progenitor cell and islet cotransplantation for diabetes
Hematopoietic stem cell transplantation for new-onset type 1 diabetes
Hematopoietic stem cells for early-onset type I diabetes mellitus
Hematopoietic stem cells for treatment of early-onset type I diabetes mellitus
Hematopoietic stem cells for type I diabetes mellitus
Human islet transplantation to treat diabetes
Porcine embryonic pancreatic tissue transplantation for diabetes
Prochymal
Regulatory T cells for type I diabetes
StemGenex
Umbilical cord-derived mesenchymal stem cells for treatment of type I diabetes
VC-01, embryonic stem cell-derived pancreatic progenitor cells for treatment of diabetes
Embryonic/Adult Cultured Cells Related to Type 1 Diabetes Mellitus:
Bone marrow-derived mesenchymal stem cells (family)
Mouse immunosuppressive dendritic cells, PMIDs: 17665986, 18552749, 23148758
Immunosuppressive dendritic cells, PMIDs: 17665986, 18552749, 23148758
Encapsulated neonatal porcine islets (DIABECELL, PMIDs: 15808678, 18814261, 17607741, 21358330, 21535153, 16131605, 23088180, 19063691, 16298643, 11202575, 17381690
Mouse Islets, PMID: 22362173
Umbilical cord blood-derived endothelial progenitor cells, PMID: 22362173
Pancreatic islets, PMID: 22362173
Peripheral blood-derived hematopoietic stem cells (family), PMID: 23190701
Peripheral blood-derived hematopoietic stem cells, PMID: 23190701
Peripheral blood-derived hematopoietic stem cells , PMID: 23190701
Bone marrow-derived hematopoietic stem cells (family)
Pancreatic islets (cadavers), PMIDs: 15983207, 10911004
Fetal pancreatic tissue, PMIDs: 16768546, 19433788
Regulatory T cells, PMIDs: 15322272, 16903917
Adipose-derived stem cells (StemGenex
Umbilical cord-derived mesenchymal stem cells (family)
Pancreatic endoderm/endocrine precursor-like cells, PMIDs: 18834446, 22623968, 18034635

Genetic Tests for Type 1 Diabetes Mellitus

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22GTR
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Genetic tests related to Type 1 Diabetes Mellitus:

id Genetic test Affiliating Genes
1 Diabetes Mellitus Type 122

Anatomical Context for Type 1 Diabetes Mellitus

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30LifeMap Discovery™, 32MalaCards
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MalaCards organs/tissues related to Type 1 Diabetes Mellitus:

32
Endothelial, Bone, Thyroid, Pancreas, T cells, Pancreatic islet, Heart, Kidney, Bone marrow, Testes, Skin, Brain, Pituitary, Liver, Ovary, Monocytes, B cells, Cortex, Myeloid, Retina, Placenta, Breast, Small intestine, Colon, Adipocyte, Whole blood

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Type 1 Diabetes Mellitus:
id TissueAnatomical CompartmentCell Relevance
1 BoneBone MarrowBone Marrow Stromal Cells Potential therapeutic candidate
2 PancreasIslets of LangerhansMature Beta Cells Potential therapeutic candidate, affected by disease
3 BloodCord BloodMesenchymal Stem Cells Potential therapeutic candidate
4 AdiposeSubcutaneous White AdiposeMesenchymal Stem Cells Potential therapeutic candidate
5 Umbilical CordWharton's JellyMesenchymal Stem Cells Potential therapeutic candidate
6 AdiposeSubcutaneous White AdiposeStromal Cells Potential therapeutic candidate

Animal Models for Type 1 Diabetes Mellitus or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Type 1 Diabetes Mellitus:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000287311.0PAX4, LRP5, INS, HLA-DQB1, GAD1, GAD2
2MP:000537910.3PTPRN, GAD2

Publications for Type 1 Diabetes Mellitus

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50PubMed
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Articles related to Type 1 Diabetes Mellitus:

(show top 50)    (show all 1243)
idTitleAuthorsYear
1
Assessment of serum levels of soluble CD40L in Egyptian children and adolescents with type 1 diabetes mellitus: Relationship to microalbuminuria and glycemic control. (24381879)
2013
2
Allograft bone transplantation for neuropathic arthropathy of the knee associated with type 1 diabetes mellitus. (22763341)
2013
3
Comparison of the effect of insulin glulisine to insulin aspart on breakfast postprandial blood glucose levels in children with type 1 diabetes mellitus on multiple daily injections. (23425652)
2013
4
Impact of experimental type 1 diabetes mellitus on systemic and coagulation vulnerability in mice acutely exposed to diesel exhaust particles. (23587270)
2013
5
Investigation The Role of Gender on The HLA-DRB1 and -DQB1 Association with Type 1 Diabetes Mellitus in Iranian Patients. (23862111)
2013
6
Augmented cardiac formation of oxidatively-induced carbonylated proteins accompanies the increased functional severity of post-myocardial infarction heart failure in the setting of type 1 diabetes mellitus. (23566587)
2013
7
Urinary biomarkers for the early diagnosis of retinopathy and nephropathy in type 1 diabetes mellitus: a "steady stream" of information using proteomics. (24355258)
2013
8
Parallel vigilance: parents' dual focus following diagnosis of Type 1 diabetes mellitus in their young child. (22801876)
2013
9
Long-term hemodynamic and molecular effects persist after discontinued renin-angiotensin system blockade in patients with type 1 diabetes mellitus. (23760288)
2013
10
Diabetic ketoacidosis presenting with pseudonormoglycemia in a 15-year-old girl with type 1 diabetes mellitus. (23748069)
2013
11
Evaluation of bone mineral density in children with type 1 diabetes mellitus. (24114897)
2013
12
Prevalence of autoantibodies in children newly diagnosed with type 1 diabetes mellitus. (22558802)
2012
13
Hypovitaminosis D in children with type 1 diabetes mellitus and its influence on biochemical and densitometric parameters. (22696930)
2012
14
Effects of body fat reduction on plasma adipocyte fatty acid-binding protein concentration in obese patients with type 1 diabetes mellitus. (23183502)
2012
15
Arterial stiffness is not increased in teens with early uncomplicated type 1 diabetes mellitus. (22297811)
2012
16
Type 1 diabetes mellitus in 2011: Heterogeneity of T1DM raises questions for therapy. (22183128)
2012
17
Continuous subcutaneous insulin infusion in adult type 1 diabetes mellitus: data from a registry at the University Medical Centre Ljubljana, Slovenia. (22971507)
2012
18
Celiac disease in type 1 diabetes mellitus. (22449104)
2012
19
Use of an intravascular fluorescent continuous glucose sensor in subjects with type 1 diabetes mellitus. (23294770)
2012
20
Sortilin-related VPS10 domain containing receptor 1 and Alzheimer's disease-associated allelic variations preferentially exist in female or type 2 diabetes mellitus patients in southern Han Chinese. (23279143)
2012
21
A novel role for epidermal growth factor receptor tyrosine kinase and its downstream endoplasmic reticulum stress in cardiac damage and microvascular dysfunction in type 1 diabetes mellitus. (22665120)
2012
22
Behaviour and metabolic control in children with Type 1 diabetes mellitus on insulin pump therapy: 2-year follow-up. (21843306)
2011
23
Retinal venular diameter as an early indicator of progression to proliferative diabetic retinopathy with and without high-risk characteristics in African Americans with type 1 diabetes mellitus. (21220623)
2011
24
Lactoferrin is a novel predictor of fatal ischemic heart disease in diabetes mellitus type 2: long-term follow-up of the HUNT 1 study. (20598696)
2010
25
Endurance capabilities of triathlon competitors with type 1 diabetes mellitus]. (19319767)
2009
26
Specificity of islet cell autoantibodies and coexistence with other organ specific autoantibodies in type 1 diabetes mellitus. (19217947)
2009
27
Lack of association of vitamin D receptor gene polymorphisms with susceptibility to type 1 diabetes mellitus in the Portuguese population. (18361940)
2008
28
Coagulation and fibrinolysis variables in pregnant women with type 1 diabetes mellitus. (18971874)
2008
29
Molecular genetics of type 1 diabetes mellitus: achievements and future trends]. (18988535)
2008
30
Glycaemic control and hypoglycaemia in children, adolescents and young adults with unstable type 1 diabetes mellitus treated with insulin glargine or intermediate-acting insulin. (17550216)
2007
31
Short- and long-term glycaemic control and the state of the renin system in type 1 diabetes mellitus. (17703435)
2007
32
Clinical and immunological characteristics of type 1 diabetes mellitus in a northwestern Colombian population. (16325957)
2006
33
Effect on coronary flow velocity reserve in patients with type 2 diabetes mellitus: comparison between angiotensin-converting enzyme inhibitor and angiotensin II type 1 receptor antagonist. (16569537)
2006
34
Comment to: Biason-Lauber A, Boehm B, Lang-Muritano M et al. (2005) association of childhood type 1 diabetes mellitus with a variant of PAX4: possible link to beta cell regenerative capacity. Diabetologia 48:900-905. (16132953)
2005
35
Cost effectiveness of ACE inhibitor treatment for patients with type 1 diabetes mellitus. (15449965)
2004
36
Leptin responses to antecedent exercise and hypoglycemia in healthy and type 1 diabetes mellitus men and women. (14583173)
2003
37
Diagnosis of acromegaly in a patient with type 1 diabetes mellitus. (11942776)
2002
38
The effect of LPS on neutrophils from patients with high risk of type 1 diabetes mellitus in relation to IL-8, IL-10 and IL-12 production and apoptosis in vitro. (11896938)
2002
39
Effect of the inflammation, chronic hyperglycemia, or malabsorption on the apolipoprotein A-IV concentration in type 1 diabetes mellitus and in diabetes secondary to chronic pancreatitis. (11555832)
2001
40
Type 1 diabetes mellitus and oral health: assessment of coronal and root caries. (11409677)
2001
41
Relationship of large multifunctional proteasome 7 gene polymorphism with susceptibility to type 1 diabetes mellitus and DR3 gene. (11793848)
2001
42
Should all patients with type 1 diabetes mellitus and microalbuminuria receive angiotensin-converting enzyme inhibitors? A meta-analysis of individual patient data. (11242497)
2001
43
Brain natriuretic peptide increases urinary albumin and alpha-1 microglobulin excretion in Type 1 diabetes mellitus. (11903396)
2001
44
HLA-DQ locus of the human leukocyte antigen complex and type 1 diabetes mellitus: a HuGE review. (11218373)
2000
45
Radioimmunoassay for glutamic acid decarboxylase (GAD65) autoantibodies as a diagnostic aid for stiff-man syndrome and a correlate of susceptibility to type 1 diabetes mellitus. (9868413)
1998
46
Apolipoprotein (a) levels in patients with type 1 diabetes mellitus are unrelated to metabolic control or vascular disease. (7856176)
1994
47
Transcapillary escape rate of albumin in hypertensive patients with type 1 (insulin-dependent) diabetes mellitus. (8436254)
1993
48
Impaired intrarenal dopamine production following intravenous sodium chloride infusion in type 1 (insulin-dependent) diabetes mellitus. (1829692)
1991
49
Prevalence of hypertension in type 1 (insulin-dependent) diabetes mellitus. (2401396)
1990
50
High heparin released platelet factor 4 in uncomplicated type 1 diabetes mellitus. (2143603)
1990

Genetic Variations for Type 1 Diabetes Mellitus

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Expression for genes affiliated with Type 1 Diabetes Mellitus

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Type 1 Diabetes Mellitus

Search GEO for disease gene expression data for Type 1 Diabetes Mellitus.

Pathways for genes affiliated with Type 1 Diabetes Mellitus

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29KEGG, 51QIAGEN, 53Reactome, 37NCBI BioSystems Database, 12EMD Millipore
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Compounds for genes affiliated with Type 1 Diabetes Mellitus

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44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 59Tocris Bioscience, 2BitterDB, 49PharmGKB
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Compounds related to Type 1 Diabetes Mellitus according to GeneCards/GeneDecks:

(show all 26)
idCompoundScoreTop Affiliating Genes
1glucose4411.6PTPRN, LSL, CTLA4, GAD2, GAD1, AKR1B1
2alanine4411.4LSL, CTLA4, GAD2, GAD1, AKR1B1, MLNR
3cholesterol44 28 11 2414.3LSL, CTLA4, GAD2, GAD1, INS, LRP5
4c-peptide4411.2LSL, GAD2, GAD1, INS, PTPRN
5glycerol44 11 2413.2INS, NAGA, AKR1B1, CSN2, LSL
6arginine4411.2LSL, GAD1, HLA-DQA1, AKR1B1, INS, PTPRN
7cyclosporin a44 28 5913.2CTLA4, GAD2, GAD1, AKR1B1, PTPRN
8hydrogen44 2412.1LSL, CSN2, GAD2, GAD1, AKR1B1
9estrogen4411.1LSL, CSN2, CTLA4, AKR1B1, INS, LRP5
10glutamate4411.1CSN2, GAD2, GAD1, PTPRN
11taurine44 59 2413.1AKR1B1, GAD1, GAD2
12valproate4411.0LSL, GAD1, AKR1B1
13pyridoxal 5-phosphate4411.0GAD2, GAD1, AKR1B1
14streptozotocin4411.0INS, AKR1B1, GAD1
15hbig4411.0INS, AKR1B1
16levodopa44 1111.9AKR1B1, GAD1, GAD2
17cysteine sulfinic acid4410.9GAD1, GAD2
18hypotaurine59 44 2412.9GAD2, GAD1
19carbon dioxide44 2411.9LSL, GAD2, GAD1
203-Sulfinoalanine11 2411.9GAD1, GAD2
21haloperidol44 28 2 49 1114.8LSL, GAD1, AKR1B1
22sibutramine44 1111.7INS, LSL
23beta-hydroxybutyrate4410.6INS, LSL
24acipimox44 2811.6INS, LSL
25oligonucleotide4410.6CSN2, GAD2, GAD1, HLA-DQB1, HLA-DQA1
26repaglinide44 49 1112.5PAX4, INS

GO Terms for genes affiliated with Type 1 Diabetes Mellitus

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16Gene Ontology
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Cellular components related to Type 1 Diabetes Mellitus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:00588611.2CTLA4, GAD2, GAD1, HLA-DQB1, HLA-DQA1, MLNR
2integral to plasma membraneGO:00588710.6TNFSF12, CTLA4, HLA-DQA1, MLNR, KIR2DS5, PTPRN
3clathrin-sculpted gamma-aminobutyric acid transport vesicle membraneGO:06120210.6GAD1, GAD2
4MHC class II protein complexGO:04261310.6HLA-DQA1, HLA-DQB1

Biological processes related to Type 1 Diabetes Mellitus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1immune responseGO:00695510.9KIR2DS5, KIR2DS2, HLA-DQA1, HLA-DQB1, CTLA4, TNFSF12
2neurotransmitter biosynthetic processGO:04213610.6GAD1, GAD2
3glutamate decarboxylation to succinateGO:00654010.5GAD2, GAD1
4T cell costimulationGO:03129510.4HLA-DQA1, HLA-DQB1, CTLA4

Molecular functions related to Type 1 Diabetes Mellitus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glutamate decarboxylase activityGO:00435110.6GAD1, GAD2
2MHC class II receptor activityGO:03239510.6HLA-DQA1, HLA-DQB1
3aldo-keto reductase (NADP) activityGO:00403310.5MIOX, AKR1B1
4glutamate bindingGO:01659510.3GAD1, GAD2

Products for genes affiliated with Type 1 Diabetes Mellitus

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Type 1 Diabetes Mellitus

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet