MCID: TYP027
MIFTS: 30

Type 1 Diabetes Mellitus 10

Categories: Metabolic diseases

Aliases & Classifications for Type 1 Diabetes Mellitus 10

MalaCards integrated aliases for Type 1 Diabetes Mellitus 10:

Name: Type 1 Diabetes Mellitus 10 12 14
Diabetes Mellitus, Insulin-Dependent, 10 69
Insulin-Dependent Diabetes Mellitus 10 12
Iddm10 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0110749
ICD10 33 E10

Summaries for Type 1 Diabetes Mellitus 10

Disease Ontology : 12 A type 1 diabetes mellitus that has material basis in mutation of the IL2RA gene on chromosome 10p15.1.

MalaCards based summary : Type 1 Diabetes Mellitus 10, also known as diabetes mellitus, insulin-dependent, 10, is related to diabetes, mellitus, insulin-dependent 10 and immunodeficiency 12. An important gene associated with Type 1 Diabetes Mellitus 10 is MTPAP (Mitochondrial Poly(A) Polymerase), and among its related pathways/superpathways are Rheumatoid arthritis and G-protein signaling_RhoB regulation pathway. The drugs Ezetimibe and Simvastatin have been mentioned in the context of this disorder. Affiliated tissues include pancreas, kidney and bone.

Related Diseases for Type 1 Diabetes Mellitus 10

Diseases related to Type 1 Diabetes Mellitus 10 via text searches within MalaCards or GeneCards Suite gene sharing:

id Related Disease Score Top Affiliating Genes
1 diabetes, mellitus, insulin-dependent 10 10.8
2 immunodeficiency 12 10.1 FUT2 HCCS NPL
3 central nervous system leiomyosarcoma 10.0 IL17A TNFRSF10A
4 cecum adenoma 9.9 HCCS IL17A
5 lymphoma 9.5 CTLA4 IL17A TNFRSF10A
6 congenital heart defects, nonsyndromic, 2 9.3 CTLA4 FUT2 HCCS NPL TNFRSF10A
7 hereditary spastic paraplegia 51 4.7 CAT CREM CTLA4 CXCL12 ENSG00000264813 FUT2

Graphical network of the top 20 diseases related to Type 1 Diabetes Mellitus 10:



Diseases related to Type 1 Diabetes Mellitus 10

Symptoms & Phenotypes for Type 1 Diabetes Mellitus 10

Drugs & Therapeutics for Type 1 Diabetes Mellitus 10

Drugs for Type 1 Diabetes Mellitus 10 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 460)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ezetimibe Approved Phase 4,Phase 3,Phase 2 163222-33-1 150311
2
Simvastatin Approved Phase 4,Phase 3,Phase 2 79902-63-9 54454
3
Exenatide Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 141758-74-9 15991534
4
Metformin Approved Phase 4,Phase 3,Phase 2,Phase 1 657-24-9 14219 4091
5
Zinc Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 7440-66-6 32051 23994
6
Glipizide Approved Phase 4,Phase 3,Phase 2 29094-61-9 3478
7
Saxagliptin Approved Phase 4,Phase 3,Phase 2,Phase 1 361442-04-8 11243969
8
Empagliflozin Approved Phase 4,Phase 3,Phase 2,Phase 1 864070-44-0
9
Liraglutide Approved Phase 4,Phase 2,Phase 3,Phase 1 204656-20-2 44147092
10
Ramipril Approved Phase 4,Phase 3,Phase 2 87333-19-5 5362129
11
Hydrocortisone Approved, Vet_approved Phase 4,Phase 3,Phase 2 50-23-7 5754 657311
12
Pancrelipase Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 53608-75-6
13
Tacrolimus Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 104987-11-3 445643 439492
14
Insulin Aspart Approved Phase 4,Phase 3,Phase 2,Phase 1 116094-23-6 16132418
15
Insulin Glargine Approved Phase 4,Phase 3,Phase 2,Phase 1 160337-95-1
16
Insulin Lispro Approved Phase 4,Phase 3,Phase 2,Phase 1 133107-64-9
17
Insulin-glulisine Approved Phase 4,Phase 3,Phase 2,Phase 1 207748-29-6
18
Adenosine Approved, Investigational Phase 4 58-61-7 60961
19
Regadenoson Approved Phase 4 313348-27-5 219024
20
Spironolactone Approved Phase 4 1952-01-7, 52-01-7 5833
21
Ethanol Approved Phase 4,Phase 2,Early Phase 1 64-17-5 702
22
Rosiglitazone Approved, Investigational Phase 4,Phase 3 122320-73-4 77999
23
Vildagliptin Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 274901-16-5 6918537
24
Glyburide Approved Phase 4,Phase 3,Phase 2,Phase 1 10238-21-8 3488
25
Heparin Approved, Investigational Phase 4,Phase 3,Phase 1 9005-49-6 772 46507594
26
Telmisartan Approved, Investigational Phase 4,Phase 3 144701-48-4 65999
27
Mitiglinide Approved, Investigational Phase 4,Phase 3 145375-43-5 3047758
28
Voglibose Approved, Investigational Phase 4,Phase 3,Phase 1 83480-29-9 444020
29
Hydrochlorothiazide Approved, Vet_approved Phase 4,Early Phase 1 58-93-5 3639
30
Indapamide Approved Phase 4 26807-65-8 3702
31
Quinapril Approved, Investigational Phase 4,Phase 3 85441-61-8 54892
32
Amlodipine Approved Phase 4,Phase 3 88150-42-9 2162
33
Benazepril Approved, Investigational Phase 4 86541-75-5 5362124
34
Valsartan Approved, Investigational Phase 4 137862-53-4 60846
35
Pioglitazone Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 111025-46-8 4829
36
Metoprolol Approved, Investigational Phase 4 37350-58-6, 51384-51-1 4171
37
Nebivolol Approved, Investigational Phase 4 152520-56-4, 99200-09-6, 118457-14-0 71301
38
Acarbose Approved, Investigational Phase 4,Phase 3 56180-94-0 441184
39
Insulin Detemir Approved Phase 4,Phase 3,Phase 2,Phase 1 169148-63-4 5311023
40
Gliclazide Approved Phase 4,Phase 3 21187-98-4 3475
41
Etanercept Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 185243-69-0
42
Repaglinide Approved, Investigational Phase 4,Phase 3 135062-02-1 65981
43
Glimepiride Approved Phase 4,Phase 3,Phase 2 93479-97-1 3476
44
Canagliflozin Approved Phase 4,Phase 3,Phase 1 842133-18-0
45
Acetaminophen Approved Phase 4,Phase 2,Phase 1 103-90-2 1983
46
Bromocriptine Approved, Investigational Phase 4,Phase 1 25614-03-3 31101
47
Dopamine Approved Phase 4,Phase 1 51-61-6, 62-31-7 681
48
Loperamide Approved Phase 4 53179-11-6 3955
49
Protein C Approved Phase 4,Phase 2
50
Nateglinide Approved, Investigational Phase 4 105816-04-4 60026

Interventional clinical trials:

(show top 50) (show all 832)

id Name Status NCT ID Phase Drugs
1 Dapagliflozin in Type 1 Diabetes Unknown status NCT02211742 Phase 4 Dapagliflozin
2 Obtain a Good Blood Glucose Control With the Paradigm Real Time System Unknown status NCT00441129 Phase 4
3 Study to Compare the Effect of Vytorin (Simvastatin/Ezetimibe) 10/20mg Versus Atorvastatin 20mg on ApoB/ApoA1 Ratio in Subjects With Diabetes Unknown status NCT01185236 Phase 4 simvastatin/ezetimibe;atorvastatin 20mg
4 Effect on Beta Cell Function and Glycaemic Control After Insulin and Exenatide Sequential Therapy Unknown status NCT02129985 Phase 4 Exenatide;Metformin
5 Outpatient Discharge Therapy With Saxagliptin+MetforminXR vs GlipizideXL for Type 2 Diabetes With Severe Hyperglycemia Unknown status NCT01267448 Phase 4 Glipizide XL;Saxagliptin + Metformin XR;Metformin XR
6 Vascular Effects of Sitagliptin in Diabetes Mellitus Unknown status NCT01096277 Phase 4 Sitagliptin;Placebo
7 The Impact of Omega-3 Supplementation on Gene Expression in Type 2 Diabetics Unknown status NCT01478776 Phase 4
8 A Study Comparing the Efficacy and Safety of the Morning Injection of Toujeo Versus Lantus in Patients With Type 1 Diabetes Mellitus Completed NCT02688933 Phase 4 Insulin glargine (U300) HOE901;Insulin glargine HOE901;Insulin glulisine HMR1964;Insulin aspart;Insulin lispro
9 Regadenoson Blood Flow in Type 1 Diabetes (RABIT1D) Completed NCT01019486 Phase 4 Regadenoson myocardial perfusion imaging;Regadenoson MRI myocardial blood flow
10 SAM - Skip a Meal - Insulin Glargine, Diabetes Mellitus Type 1 Completed NCT00313937 Phase 4 Insulin glargine
11 The Effect of Insulin Glulisine Compared With Insulin Aspart on Breakfast Post Prandial Glucose Levels in Prepubertal Children Completed NCT00913497 Phase 4 insulin glulisine;insulin aspart
12 baSal BoluS Therapy in patIenTs With TypE 1 Diabetes Mellitus Completed NCT01204593 Phase 4 INSULIN GLARGINE;INSULIN GLULISINE
13 Autoregulation of Glomerular Filtration Rate in Patients With Type 1 Diabetes During Spironolactone Therapy Completed NCT00335413 Phase 4 Spironolactone
14 Pizza-Salami Study in Children and Adolescents With Type 1 Diabetes Completed NCT01400659 Phase 4
15 Comparison Between GLP 1 Analogues and DPP 4 Inhibitors in Type 1 Diabetes Mellitus Completed NCT01235819 Phase 4 Insulin;Sitagliptin;Exenatide
16 Evaluation of Efficacy and Safety of Vardenafil in Patients With Erectile Dysfunction and Type 1 Diabetes Completed NCT00660998 Phase 4 Levitra (Vardenafil, BAY38-9456);Placebo
17 Randomized, Double Blind, 2 Way Crossover Study of CSII With, Versus Without, Pretreatment With Human Hyaluronidase Completed NCT01526733 Phase 4 Sham Injection;Recombinant human hyaluronidase PH20;Insulin aspart;Insulin lispro
18 Effect of Metformin in Patients With Type-1 Diabetes With Inadequate Glycaemic Control by Insulin and Diet Completed NCT00118937 Phase 4 Metformin;Placebo.;Placebo.
19 Improving Blood Pressure Management in Patients With Diabetes Completed NCT00374270 Phase 4
20 The Late Effects of Ethanol Intake on the Glucose Response to Subcutaneous Glucagon in Type 1 Diabetes Completed NCT02881060 Phase 4
21 Clinical Trial of Efficiency and Safety of Subetta in the Combined Treatment of Patients With Type I Diabetes Mellitus Completed NCT01868594 Phase 4 Subetta;Placebo
22 NovoLet® Acceptance Study Within the Hospital Practise in Indonesia Completed NCT01492205 Phase 4 insulin human
23 Long-term Safety and Efficacy of Empagliflozin as Add on to GLP-1 RA Completed NCT02589626 Phase 4 empagliflozin 10mg;empagliflozin 25 mg;Placebo
24 Study In Postmenopausal Women With Type 2 Diabetes Looking At Approved Diabetes Drugs And How They Affect Bone Health Completed NCT00679939 Phase 4 Rosiglitazone;Metformin
25 The Study of Exenatide Action on Vessel Function in Type 2 Diabetes and Prediabetes Completed NCT01181986 Phase 4 Exenatide SC;Exenatide IV;Placebo SC;Exendin-9;Placebo IV
26 This Study Is To Determine If Inhaled Insulin Is Effective In Treating Type 2 Diabetes Mellitus Completed NCT00418522 Phase 4 Insulin glargine;Inhaled Insulin (Exubera)
27 Effect of Glucagon-like Peptide 1 (GLP-1) on Microvascular Myocardial Function in Patients With Type 2 Diabetes. Completed NCT01931982 Phase 4 Victoza
28 Hyperbaric Oxygen Therapy (HBOT) for Chronic Diabetic Lower Limb Ulcers Completed NCT00621608 Phase 4
29 GLP-1 Mediating DPP-4 Inhibition in Type 2 Diabetes Completed NCT02639130 Phase 4 Exendin [9-39];Placebo
30 Metformin Extended Release Versus Metformin Immediate Release in Subjects With Type 2 Diabetes Completed NCT02252965 Phase 4 Metformin IR;Metformin XR
31 R230C and C230C Variants of ABCA1 and Glyburide Response Completed NCT01456650 Phase 4 Glyburide
32 Lixisenatide-The Effects on Glucose and Lipid Metabolism in Type 2 Diabetes Completed NCT02049034 Phase 4
33 Comparison of a Basal Plus One Insulin Regimen With a Biphasic Insulin Regimen in Type 2 Diabetes Patients Completed NCT00965549 Phase 4 INSULIN GLARGINE (HOE901);Insulin aspart;Insulin Glulisine
34 Bedtime Insulins and Oral Antihyperglycemic Drugs in Type 2 Diabetes Completed NCT00641407 Phase 4 NPL insulin;Insulin glargine
35 Efficacy and Safety In Poorly Controlled Type 2 Diabetics Completed NCT00044460 Phase 4 rosiglitazone
36 How Glargine Insulin, Oral Diabetes Medications and Exenatide May Improve Blood Sugar Control and Weight Gain in Type 2 Diabetics Completed NCT00667732 Phase 4 exenatide;placebo
37 Patient Preference and Satisfaction With Insulin Glargine (Lantus) Solostar Pen vs Conventional Vial-Syringe Method of Lantus Injection Therapy in Patients With Type 2 Diabetes Mellitus Completed NCT01226043 Phase 4 Insulin Glargine
38 Trial to Compare the Effects of Either Telmisartan (40-80 mg PO Once Daily) or Ramipril (5-10 mg PO Once Daily) on Renal Endothelial Dysfunction in Hypertensive Patients With Type 2 Diabetes Completed NCT00240422 Phase 4 Telmisartan;Ramipril
39 Intensive Insulin Glulisine Therapy in Patients With Type 2 Diabetes Inadequately Controlled With Basal Insulin and Oral Glucose-lowering Drugs Completed NCT01203111 Phase 4 INSULIN GLARGINE;INSULIN GLULISINE
40 Glufast On Insulin Glargine Trial in Type 2 DM Completed NCT00663884 Phase 4 Mitiglinide;Voglibose
41 A Comparison of Indapamide SR 1.5 mg With HCTZ 25 mg, in Combination With an ACE-inhibitor, in Patients With Mild to Moderate AHT and Type 2 DM Completed NCT00980187 Phase 4 Hydrochlorothiazide;Indapamide
42 Direct Renin Inhibition Effects on Atherosclerotic Biomarkers Completed NCT00818779 Phase 4 Aliskiren;Amlodipine
43 A Comparison of Adding Exenatide With Switching to Exenatide in Patients With Type 2 Diabetes Experiencing Inadequate Glycemic Control With Sitagliptin Plus Metformin Completed NCT00870194 Phase 4 exenatide and sitagliptin;exenatide and placebo
44 ADDM Study - Amtrel and Co-Diovan in Type 2 Diabetes Mellitus Hypertension Patients With Microalbuminuria Completed NCT01375322 Phase 4 Amlodipine+Benazepril;Valsartan+Hydrochlorothiazide
45 The Effect of Exenatide Compared to Lantus Insulin on Vascular Function in Type 2 Diabetes Completed NCT00353834 Phase 4 Exenatide;Glargine Insulin
46 Sitagliptin (DPP-4 Inhibitor) and NPH Insulin in Patients With T2D Completed NCT02607410 Phase 4 sitagliptin;NPH insulin
47 Pioglitazone Versus Metformin in Type 2 Diabetes Completed NCT00815399 Phase 4 Pioglitazone;Metformin
48 Study of the Glycemic Effects of Nebivolol Compared With Metoprolol and HCTZ in Diabetic Hypertensive Patients Completed NCT00744237 Phase 4 Nebivolol;Metoprolol ER;HCTZ
49 Remission Evaluation of Metabolic Interventions in Type 2 Diabetes (REMIT Pilot Trial) Completed NCT01181674 Phase 4 insulin glargine;metformin;acarbose;insulin glargine;metformin;acarbose
50 Effects of Exenatide in Type 2 Diabetic Patients With Congestive Heart Failure Completed NCT00766857 Phase 4 exenatide;Insulin glargine

Search NIH Clinical Center for Type 1 Diabetes Mellitus 10

Genetic Tests for Type 1 Diabetes Mellitus 10

Anatomical Context for Type 1 Diabetes Mellitus 10

MalaCards organs/tissues related to Type 1 Diabetes Mellitus 10:

39
Pancreas, Kidney, Bone, Testes, Heart, Endothelial, Pancreatic Islet

Publications for Type 1 Diabetes Mellitus 10

Variations for Type 1 Diabetes Mellitus 10

Expression for Type 1 Diabetes Mellitus 10

Search GEO for disease gene expression data for Type 1 Diabetes Mellitus 10.

Pathways for Type 1 Diabetes Mellitus 10

Pathways related to Type 1 Diabetes Mellitus 10 according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.75 CTLA4 CXCL12 IL17A
2 10.56 CXCL12 IL16 IL17A
3 10.45 CAT SOD2

GO Terms for Type 1 Diabetes Mellitus 10

Biological processes related to Type 1 Diabetes Mellitus 10 according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.65 CTLA4 CXCL12 IL16 IL17A TNFRSF10A
2 response to oxidative stress GO:0006979 9.58 CAT HMOX2 SOD2
3 response to cadmium ion GO:0046686 9.46 CAT SOD2
4 regulation of calcium ion transport GO:0051924 9.43 CXCL12 IL16
5 response to hyperoxia GO:0055093 9.37 CAT SOD2
6 induction of positive chemotaxis GO:0050930 9.32 CXCL12 IL16
7 response to hypoxia GO:0001666 9.26 CAT CXCL12 HMOX2 SOD2
8 response to L-ascorbic acid GO:0033591 9.16 CAT SOD2
9 response to radiation GO:0009314 8.8 CAT CXCL12 SOD2

Sources for Type 1 Diabetes Mellitus 10

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....