MCID: TYP027
MIFTS: 27

Type 1 Diabetes Mellitus 10 malady

Categories: Metabolic diseases

Aliases & Classifications for Type 1 Diabetes Mellitus 10

Aliases & Descriptions for Type 1 Diabetes Mellitus 10:

Name: Type 1 Diabetes Mellitus 10 12 14
Diabetes Mellitus, Insulin-Dependent, 10 69
Insulin-Dependent Diabetes Mellitus 10 12
Iddm10 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0110749
ICD10 33 E10

Summaries for Type 1 Diabetes Mellitus 10

Disease Ontology : 12 A type 1 diabetes mellitus that has material basis in mutation of the IL2RA gene on chromosome 10p15.1.

MalaCards based summary : Type 1 Diabetes Mellitus 10, also known as diabetes mellitus, insulin-dependent, 10, is related to diabetes, mellitus, insulin-dependent 10 and appendix carcinoid tumor. An important gene associated with Type 1 Diabetes Mellitus 10 is MTPAP (Mitochondrial Poly(A) Polymerase), and among its related pathways/superpathways are Rheumatoid arthritis and G-protein signaling_RhoB regulation pathway. The drugs Ethanol and Clonidine have been mentioned in the context of this disorder.

Related Diseases for Type 1 Diabetes Mellitus 10

Diseases related to Type 1 Diabetes Mellitus 10 via text searches within MalaCards or GeneCards Suite gene sharing:

id Related Disease Score Top Affiliating Genes
1 diabetes, mellitus, insulin-dependent 10 10.8
2 appendix carcinoid tumor 10.1 HCCS IL17A
3 heterotaxy, visceral, 6, autosomal recessive 9.9 FUT2 HCCS NPL
4 diabetes mellitus, insulin-dependent, 8 9.7 CTLA4 FUT2 HCCS NPL TNFRSF10A
5 hereditary spastic paraplegia 62 7.9 CAT CREM CTLA4 CXCL12 ENSG00000264813 FUT2

Graphical network of the top 20 diseases related to Type 1 Diabetes Mellitus 10:



Diseases related to Type 1 Diabetes Mellitus 10

Symptoms & Phenotypes for Type 1 Diabetes Mellitus 10

Drugs & Therapeutics for Type 1 Diabetes Mellitus 10

Drugs for Type 1 Diabetes Mellitus 10 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 723)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ethanol Approved Phase 4,Phase 3,Phase 2,Early Phase 1 64-17-5 702
2
Clonidine Approved Phase 4,Phase 3 4205-90-7 2803
3
Glyburide Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 10238-21-8 3488
4
Ezetimibe Approved Phase 4,Phase 3,Phase 2 163222-33-1 150311
5
Pioglitazone Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 111025-46-8 4829
6
Simvastatin Approved Phase 4,Phase 3,Phase 2,Phase 1 79902-63-9 54454
7
Zinc Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 7440-66-6 32051 23994
8
Tacrolimus Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 104987-11-3 445643 439492
9
Testosterone Approved, Investigational Phase 4,Phase 2,Phase 3 58-22-0 6013
10
Aspirin Approved, Vet_approved Phase 4,Phase 2,Phase 1 50-78-2 2244
11
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
12
Furosemide Approved, Vet_approved Phase 4 54-31-9 3440
13
Repaglinide Approved, Investigational Phase 4,Phase 3 135062-02-1 65981
14
Gliclazide Approved Phase 4,Phase 3,Early Phase 1 21187-98-4 3475
15
Glipizide Approved Phase 4,Phase 3,Phase 2,Phase 1 29094-61-9 3478
16
Metformin Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 657-24-9 14219 4091
17
Captopril Approved Phase 4 62571-86-2 44093
18
Ramipril Approved Phase 4,Phase 3,Phase 2 87333-19-5 5362129
19
Losartan Approved Phase 4,Phase 3,Phase 2 114798-26-4 3961
20
Hydrochlorothiazide Approved, Vet_approved Phase 4,Phase 3,Phase 1,Early Phase 1 58-93-5 3639
21
Amlodipine Approved Phase 4,Phase 3,Phase 1 88150-42-9 2162
22
Irbesartan Approved, Investigational Phase 4,Phase 3 138402-11-6 3749
23
Atenolol Approved Phase 4 29122-68-7 2249
24
Doxazosin Approved Phase 4 74191-85-8 3157
25
Adalimumab Approved Phase 4,Phase 2 331731-18-1 16219006
26
Hydrocortisone Approved, Vet_approved Phase 4,Phase 3,Phase 2 50-23-7 5754 657311
27
Dexmedetomidine Approved, Vet_approved Phase 4 76631-46-4, 113775-47-6 68602 5311068 56032
28
Isoflurane Approved, Vet_approved Phase 4 26675-46-7 3763
29
Exenatide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 141758-74-9 15991534
30
Triamcinolone Approved, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 124-94-7 31307
31
Dimethyl fumarate Approved, Investigational Phase 4 624-49-7 637568 5271565
32
Vildagliptin Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 274901-16-5 6918537
33
Saxagliptin Approved Phase 4,Phase 3,Phase 2,Phase 1 361442-04-8 11243969
34
Liraglutide Approved Phase 4,Phase 3,Phase 2,Phase 1 204656-20-2
35
Voglibose Approved, Investigational Phase 4,Phase 3,Phase 1 83480-29-9 444020
36
Benzocaine Approved Phase 4,Phase 3,Phase 1,Phase 2 1994-09-7, 94-09-7 2337
37
Etomidate Approved Phase 4 33125-97-2 36339 667484
38
Menthol Approved Phase 4,Phase 3,Phase 2,Phase 1 2216-51-5 16666
39
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
40
Empagliflozin Approved Phase 4,Phase 3,Phase 2,Phase 1 864070-44-0
41
Alprostadil Approved, Investigational Phase 4 745-65-3 149351
42
Insulin Glargine Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 160337-95-1
43
Insulin Detemir Approved Phase 4,Phase 3,Phase 2,Phase 1 169148-63-4 5311023
44
Methyltestosterone Approved Phase 4,Phase 2,Phase 3 58-18-4 6010
45
Alogliptin Approved Phase 4,Phase 3,Phase 1 850649-61-5 11450633
46
Linagliptin Approved Phase 4,Phase 3,Phase 2,Phase 1 668270-12-0 10096344
47
Insulin Lispro Approved Phase 4,Phase 3,Phase 2,Phase 1 133107-64-9
48
Pancrelipase Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 53608-75-6
49
Heparin Approved, Investigational Phase 4,Phase 3,Phase 1 9005-49-6 772 46507594
50
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1 51-61-6, 62-31-7 681

Interventional clinical trials:

(show top 50) (show all 1593)
id Name Status NCT ID Phase
1 Mixed Meal Test in Type 1 Diabetes on Insulin Pump Therapy: Optimization of Artificial Pancreas Unknown status NCT02003274 Phase 4
2 Dapagliflozin in Type 1 Diabetes Unknown status NCT02211742 Phase 4
3 Obtain a Good Blood Glucose Control With the Paradigm Real Time System Unknown status NCT00441129 Phase 4
4 Study to Compare the Effect of Vytorin (Simvastatin/Ezetimibe) 10/20mg Versus Atorvastatin 20mg on ApoB/ApoA1 Ratio in Subjects With Diabetes Unknown status NCT01185236 Phase 4
5 Effect on Beta Cell Function and Glycaemic Control After Insulin and Exenatide Sequential Therapy Unknown status NCT02129985 Phase 4
6 Outpatient Discharge Therapy With Saxagliptin+MetforminXR vs GlipizideXL for Type 2 Diabetes With Severe Hyperglycemia Unknown status NCT01267448 Phase 4
7 Vascular Effects of Sitagliptin in Diabetes Mellitus Unknown status NCT01096277 Phase 4
8 The Impact of Omega-3 Supplementation on Gene Expression in Type 2 Diabetics Unknown status NCT01478776 Phase 4
9 Study of Combination Therapy of Gliclazide MR and Basal Insulin Versus Insulin Monotherapy to Treat Type 2 Diabetes Unknown status NCT00736515 Phase 4
10 Effect of Testosterone on Endothelial Function and Microcirculation in Type 2 Diabetic Patients With Hypogonadism Unknown status NCT01084369 Phase 4
11 Clinical Study to Evaluate the Efficacy of Anakinra in Patients With Rheumatoid Arthritis and Diabetes Unknown status NCT02236481 Phase 4
12 Effect of Linagliptin on Insulin Sensitivity and Pancreatic Beta Cell Function in Patients With Type 2 Diabetes Mellitus Unknown status NCT02097342 Phase 4
13 The Influence of Adalimumab on Cardiovascular and Metabolic Risk in Psoriasis Unknown status NCT01088165 Phase 4
14 The Effects of Omega-3 Fatty Acid (OMACOR) on the Low-density Lipoprotein (LDL) Sub-fraction in Type 2 Diabetic Patients Unknown status NCT00758927 Phase 4
15 Aliskiren Versus Ramipril on Antiproteinuric Effect in Hypertensive, Type 2 Diabetic Patients With Microalbuminuria Unknown status NCT01038895 Phase 4
16 Effects of Vildagliptin Versus Glibenclamide on Glycemia After Exercise in Patients With Type 2 Diabetes Unknown status NCT01867502 Phase 4
17 The Effects of Short-Term Exenatide Therapy in Newly Diagnosed Type 2 Diabetic Patients Unknown status NCT01270191 Phase 4
18 Study Effects of Ginkgo Biloba Extract on Endothelial Cell Function and Genetic Effects on the Response to Ginkgo Biloba Extract in Diabetic Patients With Stable Coronary Artery Disease Unknown status NCT01038050 Phase 4
19 Efficacy and Safety of Alprostadil Prevent Contrast Induced Nephropathy Unknown status NCT01722513 Phase 4
20 Nephropathy In Type 2 Diabetes and Cardio-renal Events Unknown status NCT00535925 Phase 4
21 DPP-4 Inhibitor and Serum BNP Level of Diabetic Patients With Congestive Heart Failure Unknown status NCT02312427 Phase 4
22 The ACT-OUT Trial: ACTivity OUTcomes Based on High Carbohydrate or High Fat Diet in Metabolic Syndrome Unknown status NCT01357382 Phase 4
23 Metformin for Weight Control in Adolescents Taking Atypical Antipsychotics Unknown status NCT00845936 Phase 4
24 Dexmedetomidine Influence on the Level of Perioperative Blood Glucose and Insulin of Elderly Diabetes Patients Unknown status NCT02154074 Phase 4
25 Regadenoson Blood Flow in Type 1 Diabetes (RABIT1D) Completed NCT01019486 Phase 4
26 SAM - Skip a Meal - Insulin Glargine, Diabetes Mellitus Type 1 Completed NCT00313937 Phase 4
27 The Effect of Insulin Glulisine Compared With Insulin Aspart on Breakfast Post Prandial Glucose Levels in Prepubertal Children Completed NCT00913497 Phase 4
28 baSal BoluS Therapy in patIenTs With TypE 1 Diabetes Mellitus Completed NCT01204593 Phase 4
29 Autoregulation of Glomerular Filtration Rate in Patients With Type 1 Diabetes During Spironolactone Therapy Completed NCT00335413 Phase 4
30 Pizza-Salami Study in Children and Adolescents With Type 1 Diabetes Completed NCT01400659 Phase 4
31 Comparison Between GLP 1 Analogues and DPP 4 Inhibitors in Type 1 Diabetes Mellitus Completed NCT01235819 Phase 4
32 Evaluation of Efficacy and Safety of Vardenafil in Patients With Erectile Dysfunction and Type 1 Diabetes Completed NCT00660998 Phase 4
33 Randomized, Double Blind, 2 Way Crossover Study of CSII With, Versus Without, Pretreatment With Human Hyaluronidase Completed NCT01526733 Phase 4
34 Effect of Metformin in Patients With Type-1 Diabetes With Inadequate Glycaemic Control by Insulin and Diet Completed NCT00118937 Phase 4
35 Improving Blood Pressure Management in Patients With Diabetes Completed NCT00374270 Phase 4
36 Clinical Trial of Efficiency and Safety of Subetta in the Combined Treatment of Patients With Type I Diabetes Mellitus Completed NCT01868594 Phase 4
37 NovoLet® Acceptance Study Within the Hospital Practise in Indonesia Completed NCT01492205 Phase 4
38 Study In Postmenopausal Women With Type 2 Diabetes Looking At Approved Diabetes Drugs And How They Affect Bone Health Completed NCT00679939 Phase 4
39 The Study of Exenatide Action on Vessel Function in Type 2 Diabetes and Prediabetes Completed NCT01181986 Phase 4
40 This Study Is To Determine If Inhaled Insulin Is Effective In Treating Type 2 Diabetes Mellitus Completed NCT00418522 Phase 4
41 Changes in Bone Turnover With Exposure to a GLP-1 Receptor Agonist Completed NCT01381926 Phase 4
42 Hyperbaric Oxygen Therapy (HBOT) for Chronic Diabetic Lower Limb Ulcers Completed NCT00621608 Phase 4
43 Effect of Glucagon-like Peptide 1 (GLP-1) on Microvascular Myocardial Function in Patients With Type 2 Diabetes. Completed NCT01931982 Phase 4
44 GLP-1 Mediating DPP-4 Inhibition in Type 2 Diabetes Completed NCT02639130 Phase 4
45 Metformin Extended Release Versus Metformin Immediate Release in Subjects With Type 2 Diabetes Completed NCT02252965 Phase 4
46 Lixisenatide-The Effects on Glucose and Lipid Metabolism in Type 2 Diabetes Completed NCT02049034 Phase 4
47 R230C and C230C Variants of ABCA1 and Glyburide Response Completed NCT01456650 Phase 4
48 Comparison of a Basal Plus One Insulin Regimen With a Biphasic Insulin Regimen in Type 2 Diabetes Patients Completed NCT00965549 Phase 4
49 Bedtime Insulins and Oral Antihyperglycemic Drugs in Type 2 Diabetes Completed NCT00641407 Phase 4
50 How Glargine Insulin, Oral Diabetes Medications and Exenatide May Improve Blood Sugar Control and Weight Gain in Type 2 Diabetics Completed NCT00667732 Phase 4

Search NIH Clinical Center for Type 1 Diabetes Mellitus 10

Genetic Tests for Type 1 Diabetes Mellitus 10

Anatomical Context for Type 1 Diabetes Mellitus 10

Publications for Type 1 Diabetes Mellitus 10

Variations for Type 1 Diabetes Mellitus 10

Expression for Type 1 Diabetes Mellitus 10

Search GEO for disease gene expression data for Type 1 Diabetes Mellitus 10.

Pathways for Type 1 Diabetes Mellitus 10

Pathways related to Type 1 Diabetes Mellitus 10 according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.75 CTLA4 CXCL12 IL17A
2 10.56 CXCL12 IL16 IL17A
3 10.45 CAT SOD2

GO Terms for Type 1 Diabetes Mellitus 10

Biological processes related to Type 1 Diabetes Mellitus 10 according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.65 CTLA4 CXCL12 IL16 IL17A TNFRSF10A
2 response to oxidative stress GO:0006979 9.58 CAT HMOX2 SOD2
3 regulation of calcium ion transport GO:0051924 9.46 CXCL12 IL16
4 response to cadmium ion GO:0046686 9.43 CAT SOD2
5 response to hyperoxia GO:0055093 9.37 CAT SOD2
6 induction of positive chemotaxis GO:0050930 9.32 CXCL12 IL16
7 response to hypoxia GO:0001666 9.26 CAT CXCL12 HMOX2 SOD2
8 response to L-ascorbic acid GO:0033591 9.16 CAT SOD2
9 response to radiation GO:0009314 8.8 CAT CXCL12 SOD2

Sources for Type 1 Diabetes Mellitus 10

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....