MCID: TYP012

Type 1 Plasminogen Deficiency malady

Rare diseases category

Summaries for Type 1 Plasminogen Deficiency

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Sources:
44NIH Rare Diseases, 34MalaCards
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NIH Rare Diseases:44 Type 1 plasminogen deficiency is a genetic condition associated with chronic lesions in the pseudomembrane (tough, thick material) of the mucosa of the eye, mouth, nasopharynx, trachea, and female genital tract; decreased serum plasminogen activity; and decreased plasminogen antigen level. the lesions may be triggered by local injury and/or infection and often recur after removal of the lesion; they are caused by the deposition of fibrin (a protein involved in blood clotting) and by inflammation. the most common clinical finding is ligenous ('wood-like') conjunctivitis, a condition marked by redness and subsequent formation of pseudomembranes of part of the eye that progresses to white, yellow-white or red thick masses with a wood-like consistency that replace the normal mucosa. hydrocephalus may be present at birth in a small number of individuals.   last updated: 12/9/2008

MalaCards: Type 1 Plasminogen Deficiency, also known as hypoplasminogenemia, is related to conjunctivitis and conjunctivitis ligneous. Affiliated tissues include eye and trachea.

Aliases & Classifications for Type 1 Plasminogen Deficiency

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44NIH Rare Diseases, 63UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Aliases & Descriptions:

type 1 plasminogen deficiency 44
hypoplasminogenemia 44 63


Related Diseases for Type 1 Plasminogen Deficiency

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18GeneCards, 19GeneDecks
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Diseases related to Type 1 Plasminogen Deficiency via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1conjunctivitis10.2
2conjunctivitis ligneous10.2
3congenital plasminogen deficiency10.2
4factor v deficiency10.0

Symptoms for Type 1 Plasminogen Deficiency

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Drugs & Therapeutics for Type 1 Plasminogen Deficiency

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Type 1 Plasminogen Deficiency

Search CenterWatch for Type 1 Plasminogen Deficiency

Genetic Tests for Type 1 Plasminogen Deficiency

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Anatomical Context for Type 1 Plasminogen Deficiency

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Sources:
34MalaCards
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MalaCards organs/tissues related to Type 1 Plasminogen Deficiency:

34
Eye, Trachea

Animal Models for Type 1 Plasminogen Deficiency or affiliated genes

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Publications for Type 1 Plasminogen Deficiency

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Variations for Type 1 Plasminogen Deficiency

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Expression for genes affiliated with Type 1 Plasminogen Deficiency

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Sources:
16Gene Expression Omnibus DataSets
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Search GEO for disease gene expression data for Type 1 Plasminogen Deficiency.

Pathways for genes affiliated with Type 1 Plasminogen Deficiency

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Compounds for genes affiliated with Type 1 Plasminogen Deficiency

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GO Terms for genes affiliated with Type 1 Plasminogen Deficiency

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Products for genes affiliated with Type 1 Plasminogen Deficiency

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Type 1 Plasminogen Deficiency

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet