NIDDM
MCID: TYP009
MIFTS: 93

Type 2 Diabetes Mellitus (NIDDM) malady

Endocrine diseases category

Summaries for Type 2 Diabetes Mellitus

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8Disease Ontology, 63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 Diabetes mellitus type more...

MalaCards: Type 2 Diabetes Mellitus, also known as diabetes mellitus, non-insulin-dependent, is related to diabetes mellitus and obesity. An important gene associated with Type 2 Diabetes Mellitus is KCNJ11 (potassium inwardly-rectifying channel, subfamily J, member 11), and among its related pathways are IRS activation and Endometrial cancer. The drugs insulin and insulin, aspart, human and the compounds "sulfonamides, urea derivatives" and repaglinide have been mentioned in the context of this disorder. Affiliated tissues include endothelial, heart and bone, and related mouse phenotypes are endocrine/exocrine gland and adipose tissue.

Disease Ontology:8 A diabetes mellitus that involves high blood glucose resulting from cells fail to use insulin properly.

Description from OMIM:46 125853

Aliases & Classifications for Type 2 Diabetes Mellitus

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8Disease Ontology, 22GTR, 46OMIM, 10DISEASES, 44Novoseek, 30LifeMap Discovery™, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH, 25ICD10
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Related Diseases for Type 2 Diabetes Mellitus

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17GeneCards, 18GeneDecks
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Diseases in the Type 2 Diabetes Mellitus family:

Type 1 Diabetes Mellitus Diabetes Mellitus

Diseases related to Type 2 Diabetes Mellitus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 259)
idRelated DiseaseScoreTop Affiliating Genes
1diabetes mellitus32.6KCNJ11, HNF4A, ENPP1, PAX4, TCF7L2, SLC2A4
2obesity31.7KCNJ11, HNF4A, IRS1, INSR, SLC2A4, ENPP1
3hypertension31.5INSR
4coronary artery disease31.3IRS1, INSR, ENPP1
5atherosclerosis31.2HNF4A, IRS1, TCF7L2, ENPP1
6hepatitis31.0HNF4A
7hyperglycemia31.0ENPP1, PAX4, SLC2A4, INSR, IRS1, HNF1B
8hypoglycemia30.9KCNJ11, HNF4A, INSR, SLC2A4
9myocardial infarction30.9ENPP1
10ischemia30.8SLC2A4, INSR
11glucose intolerance30.8INSR, SLC2A4, PAX4, ENPP1
12insulinoma30.7PAX4, INSR, HNF4A, KCNJ11
13schizophrenia30.7INSR
14polycystic ovary syndrome30.7INSR, IRS1
15liver cirrhosis30.6SLC2A4, INSR, IRS1
16essential hypertension30.6INSR
17maturity-onset diabetes of the young30.5PAX4, HNF1B, HNF4A, KCNJ11
18acanthosis nigricans30.4INSR
19hyperinsulinism30.4INSR, IRS1, KCNJ11
20lipodystrophy30.4AKT2, INSR
21gestational diabetes30.4KCNJ11, HNF4A, IRS1, INSR, SLC2A4, TCF7L2
22hypertriglyceridemia30.2IRS1, INSR, SLC2A4
23hyperinsulinemic hypoglycemia30.2KCNJ11
24metabolic syndrome x30.2SLC2A4
25neonatal diabetes mellitus30.2KCNJ11, HNF1B
26leukemia30.2TCF4, PPP1R3A, IRS1
27polycystic kidney disease30.2ENPP1, HNF1B
28adenoma30.2TCF7L2, INSR, HNF4A
29stomach cancer30.1HNF4A, PPP1R3A, SLC2A4, TCF4, TCF7L2
30breast cancer30.1HNF4A, IRS1, AKT2, INSR, SLC2A4, TCF7L2
31type 1 diabetes mellitus11.1
32diabetic nephropathy11.0
33diabetic neuropathy10.9
34neuropathy10.9
35diabetic retinopathy10.9
36diabetic autonomic neuropathy10.7
37autonomic neuropathy10.7
38peripheral neuropathy10.7
39pancreatitis10.7
40periodontitis10.7
41vascular disease10.7
42alzheimer's disease10.7
43kidney disease10.7
44fatty liver disease10.6
45liver disease10.6
46lactic acidosis10.6
47hypogonadism10.6
48hypertensive heart disease10.5
49peripheral vascular disease10.5
50tuberculosis10.5

Graphical network of the top 20 diseases related to Type 2 Diabetes Mellitus:



Diseases related to type 2 diabetes mellitus

Clinical Features for Type 2 Diabetes Mellitus

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46OMIM
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Clinical features from OMIM:

125853

Drugs & Therapeutics for Type 2 Diabetes Mellitus

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Type 2 Diabetes Mellitus

Drug clinical trials:

Search ClinicalTrials for Type 2 Diabetes Mellitus

Search NIH Clinical Center for Type 2 Diabetes Mellitus

Highlights from CenterWatch's Drugs in Clinical Trials Database for Type 2 Diabetes Mellitus:

idCompanyCompoundMechanismPhase
1PhaseBio PharmaceuticalsGlymeraA long acting GLP-1 analogIIb
2RochealeglitazarA PPAR alpha and gamma modulatorII and III
3Boehringer Ingelheim/Eli LillyempagliflozinA SGLT-2 inhibitorIII
4Gilead SciencesranolazineA pFOX inhibitorIII
5Zealand PharmalixisenatideA glucagon-like peptide 1 receptor agonistIII

Inferred drug relations via UMLS60/NDF-RT40:

Show with subtypes

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Type 2 Diabetes Mellitus cell therapies at LifeMap Discovery.

Genetic Tests for Type 2 Diabetes Mellitus

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22GTR
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Genetic tests related to Type 2 Diabetes Mellitus:

id Genetic test Affiliating Genes
1 Diabetes Mellitus Type 222

Anatomical Context for Type 2 Diabetes Mellitus

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30LifeMap Discovery™, 32MalaCards
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MalaCards organs/tissues related to Type 2 Diabetes Mellitus:

32
Endothelial, Heart, Bone, Liver, Monocytes, Kidney, Skeletal muscle, Testes, T cells, Thyroid, Adipocyte, Brain, Ovary, Pancreatic islet, Lung, B cells, Pituitary, Breast, Pancreas, Colon, Bone marrow, Prostate, Smooth muscle, Retina, Skin, Myeloid, Eye, Spleen, Pons

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Type 2 Diabetes Mellitus:
id TissueAnatomical CompartmentCell Relevance
1 PancreasIslets of LangerhansMature Beta Cells Potential therapeutic candidate, affected by disease
2 AdiposeSubcutaneous White AdiposeMesenchymal Stem Cells Potential therapeutic candidate
3 AdiposeSubcutaneous White AdiposeStromal Cells Potential therapeutic candidate

Animal Models for Type 2 Diabetes Mellitus or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Type 2 Diabetes Mellitus:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.5KCNJ11, HNF1B, IRS1, SLC2A4
2MP:00053757.1KCNJ11, IRS1, PPP1R3A, AKT2, INSR, SLC2A4
3MP:00053877.0IRS1, AKT2, INSR, SLC2A4, TCF4, ENPP1
4MP:00053706.8HNF4A, HNF1B, IRS1, AKT2, INSR, SLC2A4
5MP:00036316.6KCNJ11, HNF4A, AKT2, INSR, SLC2A4, TCF4
6MP:00053696.5KCNJ11, HNF1B, IRS1, PPP1R3A, AKT2, INSR
7MP:00053765.9KCNJ11, HNF4A, HNF1B, IRS1, PPP1R3A, AKT2
8MP:00107685.8KCNJ11, HNF4A, HNF1B, IRS1, AKT2, INSR
9MP:00053785.4ENPP1, KCNJ11, HNF4A, HNF1B, IRS1, PPP1R3A

Publications for Type 2 Diabetes Mellitus

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50PubMed
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Articles related to Type 2 Diabetes Mellitus:

(show top 50)    (show all 2390)
idTitleAuthorsYear
1
The influence of angiotensin-converting enzyme 2 gene polymorphisms on type 2 diabetes mellitus and coronary heart disease. (24142614)
2013
2
Proportion of depression and its determinants among type 2 diabetes mellitus patients in various tertiary care hospitals in Mangalore city of South India. (23961486)
2013
3
The effect of duodenojejunal bypass for type 2 diabetes mellitus patients below body mass index 25 kg/m(2): one year follow-up. (24020019)
2013
4
Resistin Levels in GCF in Chronic Periodontitis Patients With Type 2 Diabetes Mellitus. (23805816)
2013
5
Reproducibility and validity of a quantitative FFQ designed for patients with type 2 diabetes mellitus from southern Brazil. (24107661)
2013
6
Abnormal myocardial perfusion and risk of heart failure in patients with type 2 diabetes mellitus. (24294048)
2013
7
Eicosapentaenoic acid improves insulin sensitivity and blood sugar in overweight type 2 diabetes mellitus patients: a double-blind randomised clinical trial. (23900468)
2013
8
Oxytocin and psychological factors affecting type 2 diabetes mellitus. (22997507)
2012
9
Increased plasma levels of nesfatin-1 in patients with newly diagnosed type 2 diabetes mellitus. (22020667)
2012
10
Paradoxical lower serum triglyceride levels and higher type 2 diabetes mellitus susceptibility in obese individuals with the PNPLA3 148M variant. (22724004)
2012
11
Simple cystatin C formula for estimation of glomerular filtration rate in overweight patients with diabetes mellitus type 2 and chronic kidney disease. (23008697)
2012
12
PON1 55 and 192 gene polymorphisms in type 2 diabetes mellitus patients in a Turkish population. (20820904)
2011
13
Sleep disorder and cardiovascular risk factors among patients with type 2 diabetes mellitus. (22016588)
2011
14
The role of IGF-1 resistance in obesity and type 2 diabetes-mellitus-related insulin resistance and vascular disease. (21058922)
2010
15
Proteomic identification of human serum biomarkers in diabetes mellitus type 2. (20015604)
2010
16
PPAR-gamma agonists and their role in type 2 diabetes mellitus management. (20216208)
2010
17
The role of postprandial hyperglycemia in the development of cardiovascular diseases in type 2 diabetes mellitus]. (20143560)
2009
18
Factors that influence retinol-binding protein 4-transthyretin interaction are not altered in overweight subjects and overweight subjects with type 2 diabetes mellitus. (19501859)
2009
19
Influence of vitamin E supplementation on endothelial complications in type 2 diabetes mellitus patients who underwent coronary artery bypass graft. (18413198)
2009
20
Atorvastatin affects low density lipoprotein and non-high density lipoprotein cholesterol relations with apolipoprotein B in type 2 diabetes mellitus: modification by triglycerides and cholesteryl ester transfer protein. (19505224)
2009
21
The effects of ileal transposition, gastrojejunal bypass and vertical gastroplasty on the regulation of ingestion in an experimental obesity model associated with diabetes mellitus type 2]. (19327756)
2009
22
Children with type 2 diabetes mellitus are at greater risk of macrovascular complications. (19419524)
2009
23
The impact of weight gain on motivation, compliance, and metabolic control in patients with type 2 diabetes mellitus. (19820278)
2009
24
Endothelial nitric oxide synthase (eNOS) is not upregulated in gastric mucosa of Helicobacter pylori (H. pylori)-positive patients with type 2 diabetes mellitus. (18657492)
2009
25
Cytochrome P450 2C9 *2 and *3 polymorphisms and the dose and effect of sulfonylurea in type II diabetes mellitus. (17597710)
2008
26
Genetic variations in the leptin and leptin receptor genes are associated with type 2 diabetes mellitus and metabolic traits in the Korean female population. (18564365)
2008
27
Type 2 diabetes mellitus and endothelial lipase. (18433755)
2008
28
Bioinformatics analysis of functional protein sequences reveals a role for brain-derived neurotrophic factor in obesity and type 2 diabetes mellitus. (17553627)
2008
29
Association of malignant insulinoma and type 2 diabetes mellitus: a case report. (18291348)
2008
30
Association of sterol regulatory element-binding protein-1c gene polymorphism with type 2 diabetes mellitus, insulin resistance and blood lipid levels in Chinese population. (18692268)
2008
31
Gender differences in the association of gene polymorphisms with type 2 diabetes mellitus. (17334638)
2007
32
Therapeutic efficacy of mitiglinide combined with once daily insulin glargine after switching from multiple daily insulin regimen of aspart insulin and glargine in patients with type 2 diabetes mellitus. (16543674)
2006
33
Association of acute-phase reactants with arterial stiffness in patients with type 2 diabetes mellitus. (16199026)
2006
34
A newly identified mutation in an IPF1 binding site of the insulin gene promoter may predispose to type 2 diabetes mellitus. (16741735)
2006
35
Association between insulin resistance and cholesteryl ester transfer protein gene polymorphism in type 2 diabetes mellitus]. (15952120)
2005
36
Association between MspI polymorphism of the APO AI gene and Type 2 diabetes mellitus. (15910632)
2005
37
Plasma adiponectin and insulin resistance in Korean type 2 diabetes mellitus. (15744804)
2005
38
Calpain-10 gene polymorphisms and type 2 diabetes in West Africans: the Africa America Diabetes Mellitus (AADM) Study. (15652721)
2005
39
Peripheral genotype-phenotype correlations in Asian Indians with type 2 diabetes mellitus. (16121806)
2005
40
Identification of influencing variables on adiponectin serum levels in diabetes mellitus type 1 and type 2. (15239024)
2004
41
The G/G genotype of a resistin single-nucleotide polymorphism at -420 increases type 2 diabetes mellitus susceptibility by inducing promoter activity through specific binding of Sp1/3. (15338456)
2004
42
Pro12Ala polymorphism of the PPAR-gamma2 gene is related to increased levels of oxidized low-density lipoprotein (LDL) autoantibodies in patients with type 2 diabetes mellitus. (14669172)
2003
43
Postprandial hyperglycemia in patients with type 2 diabetes mellitus. (15765626)
2002
44
Angiotensin-converting enzyme activity is involved in the mechanism of increased endogenous nitric oxide synthase inhibitor in patients with type 2 diabetes mellitus. (12224817)
2002
45
Study of axial bone mineral density in postmenopausal women with diffuse idiopathic skeletal hyperostosis related to type 2 diabetes mellitus. (12626079)
2002
46
Leukocyte-endothelial cell adhesion molecule 1 (LECAM-1) polymorphism is associated with diabetic nephropathy in type 2 diabetes mellitus. (12200076)
2002
47
Association of beta 3-adrenergic receptor gene with obesity in patients with type 2 diabetes mellitus]. (11769635)
2001
48
Outcome survey in unselected hypertensive patients with type 2 diabetes mellitus: effects of ACE inhibition. (11465652)
2001
49
Miglitol: a review of its therapeutic potential in type 2 diabetes mellitus. (10776834)
2000
50
Catalase and paraoxonase in hypertensive type 2 diabetes mellitus: correlation with glycemic control. (10667477)
1999

Genetic Variations for Type 2 Diabetes Mellitus

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62UniProtKB/Swiss-Prot
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Genetic disease variations for Type 2 Diabetes Mellitus:

62 (show all 33)
id Symbol AA change Variation ID SNP ID
1AKT2p.Arg274HisVAR_067310
2AKT2p.Arg274HisVAR_067310
3AKT2p.Arg274HisVAR_067310
4HNF1Bp.Ser465ArgVAR_017665
5HNF1Bp.Ser465ArgVAR_017665
6HNF1Bp.Ser465ArgVAR_017665
7HNF4Ap.Val402IleVAR_004670rs137853337
8HNF4Ap.Val402IleVAR_004670rs137853337
9HNF4Ap.Val402IleVAR_004670rs137853337
10INSRp.Arg1191GlnVAR_004098
11INSRp.Arg1191GlnVAR_004098
12INSRp.Arg1191GlnVAR_004098
13INSRp.Thr858AlaVAR_015917rs182552223
14INSRp.Thr858AlaVAR_015917rs182552223
15INSRp.Thr858AlaVAR_015917rs182552223
16INSRp.Arg1158GlnVAR_015927
17INSRp.Arg1158GlnVAR_015927
18INSRp.Arg1158GlnVAR_015927
19IRS1p.Ser1043TyrVAR_005302
20IRS1p.Ser1043TyrVAR_005302
21IRS1p.Ser1043TyrVAR_005302
22IRS1p.Cys1095TyrVAR_005303
23IRS1p.Cys1095TyrVAR_005303
24IRS1p.Cys1095TyrVAR_005303
25MAPK8IP1p.Ser59AsnVAR_012243
26MAPK8IP1p.Ser59AsnVAR_012243
27MAPK8IP1p.Ser59AsnVAR_012243
28PPP1R3Ap.Ala931GluVAR_019699rs35449651
29PPP1R3Ap.Ala931GluVAR_019699rs35449651
30PPP1R3Ap.Ala931GluVAR_019699rs35449651
31SLC2A4p.Val383IleVAR_007170rs121434581
32SLC2A4p.Val383IleVAR_007170rs121434581
33SLC2A4p.Val383IleVAR_007170rs121434581

Expression for genes affiliated with Type 2 Diabetes Mellitus

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Type 2 Diabetes Mellitus

Search GEO for disease gene expression data for Type 2 Diabetes Mellitus.

Pathways for genes affiliated with Type 2 Diabetes Mellitus

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Sources:
53Reactome, 29KEGG, 12EMD Millipore, 37NCBI BioSystems Database, 51QIAGEN, 59Tocris Bioscience, 52R&D Systems, 4Cell Signaling Technology, 49PharmGKB
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Pathways related to Type 2 Diabetes Mellitus according to GeneCards/GeneDecks:

(show all 29)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.4INSR, IRS1
2
Hide members
9.4TCF7L2, AKT2, IRS1
3
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9.4TCF7L2, AKT2, IRS1
49.3TCF7L2, TCF4, HNF4A
59.3SLC2A4, AKT2
6
Hide members
9.1INSR, AKT2, PPP1R3A
7
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9.0IRS1, AKT2, INSR
8
Development Ligand-independent activation of ESR1 and ESR2
Hide members
9.0IRS1, AKT2, INSR
99.0INSR, AKT2, IRS1
10
Hide members
9.0SLC2A4, TCF4, PAX4
11
Hide members
9.0HNF4A, AKT2, TCF4, TCF7L2
128.8IRS1, AKT2, SLC2A4
13
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8.8PAX4, AKT2, HNF1B, HNF4A
14
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8.7IRS1, AKT2, INSR, TCF7L2
15
Development Leptin signaling via PI3K-dependent pathway
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8.6KCNJ11, IRS1, AKT2, SLC2A4
168.2PPP1R3A, AKT2, INSR, SLC2A4
17
Hide members
8.2IRS1, AKT2, INSR, SLC2A4
18
Hide members
8.2IRS1, AKT2, INSR, SLC2A4
198.2SLC2A4, INSR, AKT2, IRS1
20
Hide members
8.2SLC2A4, INSR, AKT2, IRS1
21
Hide members
8.2SLC2A4, INSR, PPP1R3A, IRS1
228.1SLC2A4, INSR, AKT2, HNF4A
23
Hide members
8.1TCF7L2, TCF4, SLC2A4, AKT2, HNF4A
24
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7.9HNF4A, IRS1, AKT2, INSR, TCF4, TCF7L2
25
Translation Insulin regulation of translation
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7.8IRS1, PPP1R3A, AKT2, INSR, SLC2A4
267.5IRS1, PPP1R3A, AKT2, INSR, SLC2A4, ENPP1
27
Hide members
7.5HNF4A, IRS1, PPP1R3A, AKT2, INSR, TCF4
287.4HNF4A, IRS1, AKT2, INSR, SLC2A4, ENPP1
29
Hide members
7.3SLC2A4, INSR, IRS1, HNF1B, HNF4A, KCNJ11

Compounds for genes affiliated with Type 2 Diabetes Mellitus

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Sources:
49PharmGKB, 44Novoseek, 11DrugBank, 28IUPHAR, 59Tocris Bioscience, 24HMDB
See all sources

Compounds related to Type 2 Diabetes Mellitus according to GeneCards/GeneDecks:

(show top 50)    (show all 53)
idCompoundScoreTop Affiliating Genes
1sulfonamides, urea derivatives4910.3TCF7L2, KCNJ11
2repaglinide44 49 1112.1PAX4, TCF7L2, KCNJ11
3mononucleotide449.9TCF7L2, TCF4
4[4-({5-(AMINOCARBONYL)-4-[(3-METHYLPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENYL]ACETIC ACID119.8INSR, IRS1
5vanadyl sulfate449.7INSR, IRS1
6ag 1024449.7IRS1, INSR
7moxonidine449.7INSR, IRS1
83-o-methylglucose449.4INSR, SLC2A4
9grp-1449.4SLC2A4, INSR
10sulfonylurea449.3SLC2A4, IRS1, KCNJ11
112,4-dinitrophenol449.3SLC2A4, IRS1
12glimepiride44 49 1111.2KCNJ11, INSR, SLC2A4
13gliclazide44 49 1111.2SLC2A4, INSR, KCNJ11
14glibenclamide44 28 49 5912.1SLC2A4, INSR, KCNJ11
15phosphoenolpyruvate44 1110.1SLC2A4, IRS1, HNF4A
16c-peptide449.0KCNJ11, HNF4A, IRS1, INSR
17vanadium449.0SLC2A4, INSR, IRS1
18glutamine449.0KCNJ11, HNF4A, INSR, ENPP1
19phenylarsine oxide449.0IRS1, INSR, SLC2A4
20streptozotocin449.0SLC2A4, INSR, IRS1
21glucosamine44 11 2411.0IRS1, INSR, SLC2A4
22pioglitazone44 49 28 1111.9SLC2A4, INSR, IRS1
23anisomycin44 119.9IRS1, INSR, SLC2A4
24phosphatidylinositol-3,4,5-trisphosphate44 249.8IRS1, INSR, SLC2A4
25rosiglitazone44 49 28 11 2412.8IRS1, INSR, SLC2A4
26troglitazone44 28 59 1111.8IRS1, INSR, SLC2A4
27ibmx44 28 5910.7IRS1, INSR, SLC2A4
28okadaic acid44 599.7SLC2A4, IRS1, HNF4A
292-deoxyglucose44 119.6IRS1, PPP1R3A, INSR, SLC2A4
30sterol448.6SLC2A4, IRS1, HNF4A
31sb 20358044 599.6SLC2A4, INSR, AKT2, IRS1
32fatty acid448.5HNF4A, IRS1, SLC2A4, ENPP1
33wortmannin448.5SLC2A4, INSR, AKT2, IRS1
34palmitate448.5HNF4A, IRS1, INSR, SLC2A4
35valine448.5KCNJ11, INSR, SLC2A4
36glycerol44 11 2410.5HNF4A, IRS1, INSR, SLC2A4
37metformin44 49 1110.4KCNJ11, IRS1, INSR, SLC2A4, ENPP1
38arginine448.4KCNJ11, HNF4A, HNF1B, IRS1, INSR
39pd 98,059448.4HNF4A, IRS1, INSR, SLC2A4
40ly294002448.3IRS1, AKT2, INSR, SLC2A4, TCF7L2
41rapamycin448.3IRS1, AKT2, INSR, SLC2A4, ENPP1
42testosterone44 59 11 2411.1HNF4A, IRS1, INSR, SLC2A4, TCF7L2
43dexamethasone44 49 28 1111.1HNF4A, IRS1, INSR, SLC2A4, ENPP1
44threonine447.8HNF4A, IRS1, AKT2, INSR, SLC2A4, ENPP1
45serine447.6HNF4A, IRS1, AKT2, INSR, SLC2A4, ENPP1
46phosphatidylinositol447.5HNF4A, IRS1, AKT2, INSR, SLC2A4, TCF7L2
47tyrosine447.4HNF4A, IRS1, AKT2, INSR, SLC2A4, ENPP1
48lipid447.1HNF4A, IRS1, PPP1R3A, AKT2, INSR, SLC2A4
49glycogen44 247.8TCF7L2, TCF4, SLC2A4, INSR, AKT2, PPP1R3A
50glucose446.4ENPP1, KCNJ11, PAX4, TCF7L2, SLC2A4, INSR

GO Terms for genes affiliated with Type 2 Diabetes Mellitus

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16Gene Ontology
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Cellular components related to Type 2 Diabetes Mellitus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transcription factor complexGO:0056679.3TCF7L2, TCF4, HNF1B
2insulin receptor complexGO:0058999.1INSR, IRS1

Biological processes related to Type 2 Diabetes Mellitus according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of fat cell differentiationGO:0455999.9ENPP1, TCF7L2
2positive regulation of glucose import in response to insulin stimulusGO:20012759.8IRS1, AKT2
3positive regulation of glucose metabolic processGO:0109079.8AKT2, IRS1
4positive regulation of fatty acid beta-oxidationGO:0320009.8AKT2, IRS1
5embryonic digestive tract morphogenesisGO:0485579.7TCF7L2, HNF1B
6negative regulation of insulin receptor signaling pathwayGO:0466279.6ENPP1, IRS1
7negative regulation of insulin secretionGO:0466769.5IRS1, KCNJ11
8endocrine pancreas developmentGO:0310189.4PAX4, HNF1B, HNF4A
9response to glucose stimulusGO:0097499.3TCF7L2, HNF1B, HNF4A
10positive regulation of glycogen biosynthetic processGO:0457259.3IRS1, AKT2, INSR
11positive regulation of glucose importGO:0463269.3INSR, AKT2, IRS1
12insulin receptor signaling pathwayGO:0082869.1IRS1, AKT2, INSR
13cellular response to insulin stimulusGO:0328698.2ENPP1, SLC2A4, INSR, AKT2, IRS1
14glucose homeostasisGO:0425938.0HNF4A, IRS1, INSR, SLC2A4, TCF7L2

Molecular functions related to Type 2 Diabetes Mellitus according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1RNA polymerase II core promoter proximal region sequence-specific DNA bindingGO:0009789.8TCF7L2, TCF4
2insulin-like growth factor receptor bindingGO:0051599.6INSR, IRS1
3insulin receptor bindingGO:0051589.6IRS1, ENPP1
4phosphatidylinositol 3-kinase bindingGO:0435489.5IRS1, INSR
5transcription regulatory region DNA bindingGO:0442129.2HNF4A, HNF1B, TCF7L2
6SH2 domain bindingGO:0421699.1INSR, IRS1
7sequence-specific DNA bindingGO:0435659.0PAX4, TCF7L2, HNF1B, HNF4A
8sequence-specific DNA binding transcription factor activityGO:0037008.7PAX4, TCF7L2, TCF4, HNF1B, HNF4A
9protein bindingGO:0055156.2HNF4A, HNF1B, IRS1, AKT2, INSR, SLC2A4

Products for genes affiliated with Type 2 Diabetes Mellitus

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Type 2 Diabetes Mellitus

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet