NIDDM
MCID: TYP009
MIFTS: 100

Type 2 Diabetes Mellitus (NIDDM) malady

Genetic diseases, Endocrine diseases, Metabolic diseases, Rare diseases categories

Summaries for Type 2 Diabetes Mellitus

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MedlinePlus:33 Diabetes means your blood glucose, or blood sugar, levels are too high. with type 2 diabetes, the more common type, your body does not make or use insulin well. insulin is a hormone that helps glucose get into your cells to give them energy. without insulin, too much glucose stays in your blood. over time, high blood glucose can lead to serious problems with your heart, eyes, kidneys, nerves, and gums and teeth. you have a higher risk of type 2 diabetes if you are older, obese, have a family history of diabetes, or do not exercise. having prediabetes also increases your risk. prediabetes means that your blood sugar is higher than normal but not high enough to be called diabetes. the symptoms of type 2 diabetes appear slowly. some people do not notice symptoms at all. the symptoms can include being very thirsty urinating often feeling very hungry or tired losing weight without trying having sores that heal slowly having blurry eyesight a blood test can show if you have diabetes. many people can manage their diabetes through healthy eating, physical activity, and blood glucose testing. some people also need to take diabetes medicines. nih: national institute of diabetes and digestive and kidney diseases

MalaCards based summary: Type 2 Diabetes Mellitus, also known as diabetes mellitus, non-insulin-dependent, is related to diabetes mellitus and atherosclerosis, and has symptoms including autosomal dominant inheritance, insulin resistance and late onset. An important gene associated with Type 2 Diabetes Mellitus is KCNJ11 (potassium inwardly-rectifying channel, subfamily J, member 11), and among its related pathways are L1CAM interactions and Metabolism. The drugs insulin and insulin, aspart, human and the compounds glucose and glycogen have been mentioned in the context of this disorder. Affiliated tissues include heart, endothelial and kidney, and related mouse phenotypes are growth/size/body and homeostasis/metabolism.

Disease Ontology:9 A diabetes mellitus that involves high blood glucose resulting from cells fail to use insulin properly.

Wikipedia:64 Diabetes mellitus type more...

Description from OMIM:46 125853

Aliases & Classifications for Type 2 Diabetes Mellitus

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Type 2 Diabetes Mellitus, Aliases & Descriptions:

Name: Type 2 Diabetes Mellitus 31 9 11
Diabetes Mellitus, Non-Insulin-Dependent 46 61
Diabetes Mellitus, Type 2 46 61
Type Ii Diabetes Mellitus 9 23
Diabetes Type 2 33 61
 
Niddm 9 44
Non-Insulin-Dependent Diabetes Mellitus 9
Diabetes Mellitus, Type Ii 46
Diabetes, Type 2 46


Classifications:



External Ids:

Disease Ontology9 DOID:9352
OMIM46 125853
NCIt39 C26747
MeSH34 D003924

Related Diseases for Type 2 Diabetes Mellitus

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Diseases in the Type 1 Diabetes Mellitus family:

Diabetes Mellitus type 2 diabetes mellitus

Diseases related to Type 2 Diabetes Mellitus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 285)
idRelated DiseaseScoreTop Affiliating Genes
1diabetes mellitus32.7SLC2A4, SLC2A2, ENPP1, GCGR, HNF4A, PPARG
2atherosclerosis32.3CAPN10, IRS1, TCF7L2, PPARG, ENPP1, HNF4A
3diabetic nephropathy32.2ENPP1, HNF1B, PPARG
4obesity32.1PPARG, ABCC8, KCNJ11, INSR, IRS1, CAPN10
5insulin resistance32.1INSR, PAX4, IRS1, AKT2, CAPN10, HNF1B
6glucose intolerance31.9SLC2A4, ENPP1, CAPN10, PPARG, INSR, PAX4
7fatty liver disease31.9PPARG, INSR, HNF4A
8hypertriglyceridemia31.9SLC2A4, IRS1, INSR, PPARG
9polycystic ovary syndrome31.8CAPN10, IRS1, INSR
10hyperandrogenism31.7INSR, PPARG, CAPN10
11maturity-onset diabetes of the young31.6HNF1B, KCNJ11, NEUROD1, HNF4A, PAX4
12type 1 diabetes mellitus31.6INSR, PAX4, HNF4A, ENPP1, NEUROD1
13liver cirrhosis31.5SLC2A4, IRS1, INSR
14hyperglycemia31.5PPARG, ABCC8, KCNJ11, INSR, PAX4, NEUROD1
15insulinoma31.4HNF4A, ABCC8, KCNJ11, GPD2, INSR, PAX4
16hypoglycemia31.4ABCC8, SLC2A2, SLC2A4, GCGR, HNF4A, KCNJ11
17gestational diabetes31.4IRS1, TCF7L2, CAPN10, HNF4A, ENPP1, SLC2A4
18hyperinsulinism31.3IRS1, INSR, KCNJ11, ABCC8, PPARG
19metabolic syndrome x31.1PPARG, SLC2A4
20lipodystrophy31.1PPARG, INSR, AKT2
21hyperinsulinemic hypoglycemia31.1KCNJ11, ABCC8
22ischemia31.1MAPK8IP1, ABCC8, SLC2A4, INSR
23permanent neonatal diabetes mellitus31.0KCNJ11, ABCC8
24lung cancer31.0HNF4A, AKT2, TCF7L2, IRS1, PPARG
25adenoma31.0HNF4A, TCF7L2, PPARG, INSR
26stomach cancer30.8PPP1R3A, SLC2A4, HNF4A, TCF4, TCF7L2
27breast cancer30.6PPARG, INSR, IRS1, AKT2, HNF4A, SLC2A2
28hypertension11.1
29endotheliitis11.1
30artery disease11.0
31neuropathy11.0
32blindness10.9
33diabetic retinopathy10.9
34autonomic neuropathy10.8
35hepatitis10.8
36pancreatitis10.8
37periodontitis10.8
38peripheral neuropathy10.8
39alzheimer's disease10.7
40myocardial infarction10.7
41vascular disease10.7
42kidney disease10.7
43liver disease10.7
44lactic acidosis10.6
45hypercholesterolemia10.6
46primary hyperoxaluria10.6HNF1B, INSR, HNF4A, ENPP1, CAPN10, PPARG
47insulin resistance, severe, digenic10.6PPP1R3A, PPARG
48diabetic neuropathy10.6
49hypogonadism10.6
50tuberculosis10.6

Graphical network of the top 20 diseases related to Type 2 Diabetes Mellitus:



Diseases related to type 2 diabetes mellitus

Symptoms for Type 2 Diabetes Mellitus

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Symptoms by clinical synopsis from OMIM:

125853

Clinical features from OMIM:

125853

HPO human phenotypes related to Type 2 Diabetes Mellitus:

id Description Frequency HPO Source Accession
1 autosomal dominant inheritance HP:0000006
2 insulin resistance HP:0000855
3 late onset HP:0003584
4 type ii diabetes mellitus HP:0005978

Drugs & Therapeutics for Type 2 Diabetes Mellitus

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Drug clinical trials:

Search ClinicalTrials for Type 2 Diabetes Mellitus

Search NIH Clinical Center for Type 2 Diabetes Mellitus

Inferred drug relations via UMLS61/NDF-RT40:

Show with subtypes

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Type 2 Diabetes Mellitus cell therapies at LifeMap Discovery.

Genetic Tests for Type 2 Diabetes Mellitus

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Genetic tests related to Type 2 Diabetes Mellitus:

id Genetic test Affiliating Genes
1 Diabetes Mellitus Type 223

Anatomical Context for Type 2 Diabetes Mellitus

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MalaCards organs/tissues related to Type 2 Diabetes Mellitus:

32
Heart, Endothelial, Kidney, Bone, Testes, Eye, Liver, Monocytes, Skeletal muscle, Brain, Adipocyte, Thyroid, Ovary, T cells, Lung, B cells, Pancreatic islet, Pituitary, Neutrophil, Bone marrow, Spleen, Retina, Smooth muscle, Colon, Pancreas, Breast, Skin, Prostate, Myeloid, Nk cells, Pons

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Type 2 Diabetes Mellitus:
id TissueAnatomical CompartmentCell Relevance
1 PancreasIslets of LangerhansMature Beta Cells Potential therapeutic candidate, affected by disease
2 AdiposeSubcutaneous White AdiposeMesenchymal Stem Cells Potential therapeutic candidate
3 AdiposeSubcutaneous White AdiposeStromal Cells Potential therapeutic candidate

Animal Models for Type 2 Diabetes Mellitus or affiliated genes

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Publications for Type 2 Diabetes Mellitus

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Articles related to Type 2 Diabetes Mellitus:

(show top 50)    (show all 2254)
idTitleAuthorsYear
1
Postprandial Glycemic Control Conditions in Relation to Urinary N-Acetyl-I^-d-Glucosaminidase in Patients with Type 2 Diabetes Mellitus Without Low Glomerular Filtration Rate. (24111861)
2014
2
Chitosan-decorated selenium nanoparticles as protein carriers to improve the in vivo half-life of the peptide therapeutic BAY 55-9837 for type 2 diabetes mellitus. (25378923)
2014
3
Albuminuria and management of type 2 diabetes mellitus. (23880799)
2013
4
Baseline characteristics in the Bardoxolone methyl EvAluation in patients with Chronic kidney disease and type 2 diabetes mellitus: the Occurrence of renal eveNts (BEACON) trial. (24169612)
2013
5
Type 2 diabetes mellitus and invokana: an FDA approved drug. (24160357)
2013
6
The prevalence of orthostatic hypotension in type 2 diabetes mellitus patients in a diabetic clinic in Enugu South-East Nigeria. (24180143)
2013
7
Preliminary results of pinpoint plantar long-wavelength infrared light irradiation on blood glucose, insulin and stress hormones in patients with type 2 diabetes mellitus. (24204095)
2013
8
Lipids and lipoprotein ratios: contribution to carotid intima media thickness in adolescents and young adults with type 2 diabetes mellitus. (24079285)
2013
9
Genetic polymorphisms of the TLR4 gene and their association with susceptibility to type 2 diabetes mellitus in the Chinese population. (24085443)
2013
10
Diet and kidney disease in high-risk individuals with type 2 diabetes mellitus. (23939297)
2013
11
Comparative effect of angiotensin II type I receptor blockers on serum uric acid in hypertensive patients with type 2 diabetes mellitus: a retrospective observational study. (24180232)
2013
12
Prevalence and determinants of hyperuricemia in type 2 diabetes mellitus patients with central obesity in Guangdong Province in China. (24231020)
2013
13
The type 2 diabetes mellitus susceptibility gene IGF2BP2 is associated with schizophrenia in a Han Chinese population. (23656854)
2013
14
Plasma adrenomedullin and subclinical cardiorenal syndrome in patients with type 2 diabetes mellitus. (22971508)
2012
15
Plasma proprotein convertase subtilisin kexin type 9 is not altered in subjects with impaired glucose metabolism and type 2 diabetes mellitus, but its relationship with non-HDL cholesterol and apolipoprotein B may be modified by type 2 diabetes mellitus: The CODAM study. (21497351)
2011
16
Serum insulin-like growth factor-I is negatively associated with serum adiponectin in type 2 diabetes mellitus. (21839662)
2011
17
Heterogeneity of genetic associations of CDKAL1 and HHEX with susceptibility of type 2 diabetes mellitus by gender. (21368910)
2011
18
PON1 55 and 192 gene polymorphisms in type 2 diabetes mellitus patients in a Turkish population. (20820904)
2011
19
Lysosomal I^-galactosidase and I^-hexosaminidase activities correlate with clinical stages of dementia associated with Alzheimer's disease and type 2 diabetes mellitus. (21321400)
2011
20
Association of interleukin-4 promoter polymorphisms in Taiwanese patients with type 2 diabetes mellitus. (20580039)
2010
21
The role of IGF-1 resistance in obesity and type 2 diabetes-mellitus-related insulin resistance and vascular disease. (21058922)
2010
22
Exercise training ameliorates the effects of rosiglitazone on traditional and novel cardiovascular risk factors in patients with type 2 diabetes mellitus. (19922961)
2010
23
Oxidative stress and platelet activation: markers of myocardial infarction in type 2 diabetes mellitus. (19759031)
2010
24
Serum levels of proamylin and amylin in normal subjects and patients with impaired glucose regulation and type 2 diabetes mellitus. (20509034)
2010
25
Positive correlations of liver enzymes with metabolic syndrome including insulin resistance in newly diagnosed type 2 diabetes mellitus. (20972737)
2010
26
Plasma apolipoprotein M responses to statin and fibrate administration in type 2 diabetes mellitus. (20828695)
2010
27
Valsartan increases circulating adiponectin levels without changing HOMA-IR in patients with type 2 diabetes mellitus and hypertension. (20233535)
2010
28
Alterations of insulin resistance and the serum adiponectin level in patients with type 2 diabetes mellitus under the usual antihypertensive dosage of telmisartan treatment. (20388049)
2010
29
Pleiotropic effects of mitiglinide in type 2 diabetes mellitus. (20146890)
2009
30
Long-term pioglitazone therapy improves arterial stiffness in patients with type 2 diabetes mellitus. (19446110)
2009
31
Miglitol increases the adiponectin level and decreases urinary albumin excretion in patients with type 2 diabetes mellitus. (17950094)
2007
32
The interactive role of type 2 diabetes mellitus and E-selectin S128R mutation on susceptibility to coronary heart disease. (17578587)
2007
33
Effects of carvedilol versus metoprolol on endothelial function and oxidative stress in patients with type 2 diabetes mellitus. (17586413)
2007
34
The common C49620T polymorphism in the sulfonylurea receptor gene (ABCC8), pancreatic beta cell function and long-term diabetic complications in obese patients with long-lasting type 2 diabetes mellitus. (17516295)
2007
35
Preventing macrovascular complications in type 2 diabetes mellitus: glucose control and beyond. (17665747)
2007
36
Influence of insulin therapy on expression of chemokine receptor CCR5 and selected inflammatory markers in patients with type 2 diabetes mellitus. (17966842)
2007
37
Recombinant human insulin-like growth factor-I treatment inhibits gluconeogenesis in a transgenic mouse model of type 2 diabetes mellitus. (16513827)
2006
38
The Leu7Pro polymorphism of neuropeptide Y is associated with younger age of onset of type 2 diabetes mellitus and increased risk for nephropathy in subjects with diabetic retinopathy. (16705546)
2006
39
Efficacy of a pedometer-based physical activity program on parameters of diabetes control in type 2 diabetes mellitus. (16979410)
2006
40
Long-term treatment with nifedipine modulates procoagulant marker and C-C chemokine in hypertensive patients with type 2 diabetes mellitus. (15668187)
2005
41
High serum interleukin-18 concentrations in patients with coronary artery disease and type 2 diabetes mellitus. (16266856)
2005
42
Atorvastatin: a review of its use in the primary prevention of cardiovascular events in patients with type 2 diabetes mellitus. (15610062)
2005
43
HMG-CoA reductase inhibitors prevent bone loss in patients with Type 2 diabetes mellitus. (15317608)
2004
44
Beneficial effects of triple drug combination of pioglitazone with glibenclamide and metformin in type 2 diabetes mellitus patients on insulin therapy. (15260389)
2003
45
Newer insulin therapies for management of type 1 and type 2 diabetes mellitus. (16563061)
2003
46
Plasma phospholipid transfer protein activity and small, dense LDL in type 2 diabetes mellitus. (12662160)
2003
47
Therapeutic options for the management of type 2 diabetes mellitus. (12437315)
2002
48
The human amylin analog, pramlintide, reduces postprandial hyperglucagonemia in patients with type 2 diabetes mellitus. (12384827)
2002
49
Analysis of slc19a2, on 1q23.3 encoding a thiamine transporter as a candidate gene for type 2 diabetes mellitus in pima indians. (11286512)
2001
50
A susceptibility locus for early-onset non-insulin dependent (type 2) diabetes mellitus maps to chromosome 20q, proximal to the phosphoenolpyruvate carboxykinase gene. (9285775)
1997

Variations for Type 2 Diabetes Mellitus

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UniProtKB/Swiss-Prot genetic disease variations for Type 2 Diabetes Mellitus:

63 (show all 11)
id Symbol AA change Variation ID SNP ID
1AKT2p.Arg274HisVAR_067310
2HNF1Bp.Ser465ArgVAR_017665
3HNF4Ap.Val402IleVAR_004670rs137853337
4INSRp.Arg1191GlnVAR_004098
5INSRp.Thr858AlaVAR_015917rs182552223
6INSRp.Arg1158GlnVAR_015927
7IRS1p.Ser1043TyrVAR_005302
8IRS1p.Cys1095TyrVAR_005303
9MAPK8IP1p.Ser59AsnVAR_012243
10PPP1R3Ap.Ala931GluVAR_019699rs35449651
11SLC2A4p.Val383IleVAR_007170rs121434581

Clinvar genetic disease variations for Type 2 Diabetes Mellitus:

7 (show all 32)
id Gene Name Type Significance SNP ID Assembly Location
1HNF1BNM_000458.2(HNF1B): c.1395C> G (p.Ser465Arg)single nucleotide variantPathogenicrs121918673GRCh37Chr 17, 36061127: 36061127
2ENPP1ENPP1, IVS20AS, 1-BP DEL, T, -11deletionrisk factor
3ENPP1NM_006208.2(ENPP1): c.517A> C (p.Lys173Gln)single nucleotide variantrisk factorrs1044498GRCh37Chr 6, 132172368: 132172368
4PAX4NM_006193.2(PAX4): c.361C> T (p.Arg121Trp)single nucleotide variantPathogenicrs114202595GRCh37Chr 7, 127254587: 127254587
5AKT2NM_001626.5(AKT2): c.821G> A (p.Arg274His)single nucleotide variantPathogenicrs121434593GRCh37Chr 19, 40743886: 40743886
6SLC30A8NM_173851.2(SLC30A8): c.412C> T (p.Arg138Ter)single nucleotide variantprotectivers200185429GRCh37Chr 8, 118165323: 118165323
7SLC30A8NM_173851.2(SLC30A8): c.101_107delAAGATCA (p.Lys34Serfs)deletionprotectiveGRCh37Chr 8, 118159222: 118159228
8LIPCLIPC, -250G-Asingle nucleotide variantrisk factor
9INSRNM_000208.2(INSR): c.3572G> A (p.Arg1191Gln)single nucleotide variantPathogenicrs121913150GRCh37Chr 19, 7120718: 7120718
10INSRNM_000208.2(INSR): c.3034G> A (p.Val1012Met)single nucleotide variantLikely pathogenic, Pathogenicrs1799816GRCh37Chr 19, 7125518: 7125518
11IL6IL6, -174G-Csingle nucleotide variantrisk factor
12GPD2NM_001083112.2(GPD2): c.1904T> C (p.Phe635Ser)single nucleotide variantPathogenicrs121918407GRCh37Chr 2, 157435621: 157435621
13SLC2A2NM_000340.1(SLC2A2): c.589G> A (p.Val197Ile)single nucleotide variantPathogenicrs121909741GRCh37Chr 3, 170724960: 170724960
14GCGRNM_000160.4(GCGR): c.118G> A (p.Gly40Ser)single nucleotide variantPathogenicrs1801483GRCh37Chr 17, 79767715: 79767715
15IGF2BP2NM_006548.4(IGF2BP2): c.239+29254C> Asingle nucleotide variantrisk factorrs4402960GRCh37Chr 3, 185511687: 185511687
16IRS1IRS1, 3-BP DEL, GLY723deletionPathogenic
17IRS1NM_005544.2(IRS1): c.1823C> G (p.Thr608Arg)single nucleotide variantPathogenicrs104893642GRCh37Chr 2, 227661632: 227661632
18HMGA1HMGA1, 1-BP INS, IVS5, -13insertionrisk factor
19RETNRETN, +62G-Asingle nucleotide variantrisk factor
20CAPN10NM_023083.3(CAPN10): c.471-176G> Asingle nucleotide variantrisk factorrs3792267GRCh37Chr 2, 241531174: 241531174
21CAPN10CAPN10, IVS6, INS/DEL, 39-BPindelrisk factor
22CAPN10CAPN10, IVS13, g.16378G-Tsingle nucleotide variantrisk factor
23CAPN10CAPN10, IVS3, g.4841T-Csingle nucleotide variantrisk factor
24MAPK8IP1NM_005456.3(MAPK8IP1): c.176G> A (p.Ser59Asn)single nucleotide variantPathogenicrs119489103GRCh37Chr 11, 45919710: 45919710
25TCF7L2NM_030756.4(TCF7L2): c.382-41435C> Tsingle nucleotide variantrisk factorrs7903146GRCh37Chr 10, 114758349: 114758349
26TCF7L2NM_030756.4(TCF7L2): c.483+9017G> Tsingle nucleotide variantrisk factorrs12255372GRCh37Chr 10, 114808902: 114808902
27TCF7L2NM_030756.4(TCF7L2): c.483+7162G> Csingle nucleotide variantrisk factorrs11196205GRCh37Chr 10, 114807047: 114807047
28NEUROD1NM_002500.4(NEUROD1): c.332G> T (p.Arg111Leu)single nucleotide variantPathogenicrs104893649GRCh37Chr 2, 182543256: 182543256
29KCNJ11NM_000525.3(KCNJ11): c.67A> G (p.Lys23Glu)single nucleotide variantdrug response, risk factorrs5219GRCh37Chr 11, 17409572: 17409572
30ABCC8NM_001287174.1(ABCC8): c.4138C> T (p.Arg1380Cys)single nucleotide variantPathogenicrs137852673GRCh37Chr 11, 17417462: 17417462
31ABCC8NM_001287174.1(ABCC8): c.1744C> G (p.Leu582Val)single nucleotide variantPathogenicrs137852674GRCh37Chr 11, 17452434: 17452434
32HNF4ANM_000457.4(HNF4A): c.1204G> A (p.Val402Ile)single nucleotide variantPathogenicrs137853337GRCh37Chr 20, 43057049: 43057049

Expression for genes affiliated with Type 2 Diabetes Mellitus

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LifeMap Discovery
Genes differentially expressed in tissues of Type 2 Diabetes Mellitus patients vs. healthy controls: 31 (show all 51)
id Gene Description Tissue Up/Dn Fold Change (log2) P value
1REG3Aregenerating islet-derived 3 alphaPancreas+5.010.004
2REG1Pregenerating islet-derived 1 pseudogenePancreas+3.890.011
3MMP7matrix metallopeptidase 7 (matrilysin, uterine)Pancreas+3.610.006
4REG3Gregenerating islet-derived 3 gammaPancreas+3.330.034
5PCOLCE2procollagen C-endopeptidase enhancer 2Pancreas+3.200.000
6TSHRthyroid stimulating hormone receptorPancreas+3.150.003
7SERPINA3serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3Pancreas+3.120.000
8MYCNv-myc avian myelocytomatosis viral oncogene neuroblastoma derived homologPancreas-2.990.004
9CCL2chemokine (C-C motif) ligand 2Pancreas+2.770.032
10C3complement component 3Pancreas+2.730.029
11CHL1cell adhesion molecule L1-likePancreas-2.510.008
12COL26A1collagen, type XXVI, alpha 1Pancreas+2.490.032
13CFTRcystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)Pancreas+2.420.033
14REG1Aregenerating islet-derived 1 alphaPancreas+2.400.004
15INHBEinhibin, beta EPancreas+2.370.039
16ESM1endothelial cell-specific molecule 1Pancreas-2.320.018
17ALBalbuminPancreas+2.250.047
18PCK1phosphoenolpyruvate carboxykinase 1 (soluble)Pancreas+2.240.007
19TBL1Xtransducin (beta)-like 1X-linkedSkeletal Muscle-2.240.015
20SCGB1D2secretoglobin, family 1D, member 2Skeletal Muscle-2.180.013
21CDH19cadherin 19, type 2Pancreas+2.110.026
22SEC14L3SEC14-like 3 (S. cerevisiae)Pancreas+2.100.046
23BNIP1BCL2/adenovirus E1B 19kDa interacting protein 1Pancreas-2.070.033
24RAD52RAD52 homolog (S. cerevisiae)Pancreas+2.050.043
25KANK4KN motif and ankyrin repeat domains 4Pancreas+2.030.025
26NHLH2nescient helix loop helix 2Pancreas+2.020.013
27ANPEPalanyl (membrane) aminopeptidasePancreas+1.980.009
28FARSAphenylalanyl-tRNA synthetase, alpha subunitPancreas+1.980.040
29LOC283731uncharacterized LOC283731Pancreas-1.970.026
30LY96lymphocyte antigen 96Pancreas+1.950.037
31ANKRD22ankyrin repeat domain 22Skeletal Muscle+1.940.026
32MIR7-3HGMIR7-3 host gene (non-protein coding)Skeletal Muscle+1.930.014
33HGFhepatocyte growth factor (hepapoietin A; scatter factor)Pancreas+1.930.033
34FNTAfarnesyltransferase, CAAX box, alphaPancreas+1.920.031
35REG1Bregenerating islet-derived 1 betaPancreas+1.900.039
36PCDH20protocadherin 20Pancreas-1.890.043
37SLC2A2solute carrier family 2 (facilitated glucose transporter), member 2Pancreas-1.860.004
38KCNQ1potassium voltage-gated channel, KQT-like subfamily, member 1Pancreas+1.780.017
39DTX1deltex 1, E3 ubiquitin ligasePancreas+1.750.017
40NOTCH2NLnotch 2 N-terminal likeSkeletal Muscle+1.730.045
41CPA2carboxypeptidase A2 (pancreatic)Pancreas+1.720.041
42CTGFconnective tissue growth factorPancreas-1.690.046
43WNT6wingless-type MMTV integration site family, member 6Pancreas-1.640.009
44MDFICMyoD family inhibitor domain containingPancreas+1.620.003
45PLA1Aphospholipase A1 member APancreas-1.610.022
46CA12carbonic anhydrase XIIPancreas+1.600.035
47SYT1synaptotagmin IPancreas+1.560.032
48SV2Bsynaptic vesicle glycoprotein 2BPancreas+1.560.028
49S100A14S100 calcium binding protein A14Pancreas+1.550.049
50ZNF660zinc finger protein 660Skeletal Muscle+1.550.043
51DKK3dickkopf WNT signaling pathway inhibitor 3Pancreas+1.530.044

Expression patterns in normal tissues for genes affiliated with Type 2 Diabetes Mellitus

Search GEO for disease gene expression data for Type 2 Diabetes Mellitus.

Pathways for genes affiliated with Type 2 Diabetes Mellitus

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Pathways related to Type 2 Diabetes Mellitus according to GeneCards/GeneDecks:

(show all 36)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
10.5PPARG, PAX4, NEUROD1, TCF4, AKT2, HNF1B
2
Show member pathways
10.5PPARG, ABCC8, KCNJ11, GPD2, GCGR, ENPP1
310.5PPARG, INSR, NEUROD1, IRS1, AKT2, HNF4A
4
Show member pathways
10.5INSR, IRS1, TCF7L2, TCF4, AKT2, MAPK8IP1
5
Show member pathways
10.5SLC2A2, ABCC8, KCNJ11, INSR, NEUROD1, IRS1
6
Show member pathways
10.5PPP1R3A, INSR, IRS1, TCF7L2, TCF4, AKT2
7
Show member pathways
10.5PAX4, NEUROD1, AKT2, HNF1B, HNF4A, SLC2A2
8
Show member pathways
10.5TCF7L2, TCF4, AKT2, HNF4A
9
Show member pathways
10.5TCF7L2, TCF4, AKT2, HNF4A, SLC2A4, SLC2A2
10
Show member pathways
DNA damage response (only ATM dependent)37
Wnt Signaling Pathway and Pluripotency37
10.5INSR, IRS1, TCF7L2, AKT2
1110.5ABCC8, KCNJ11, IRS1, AKT2, SLC2A4
12
Show member pathways
10.5AKT2, IRS1, INSR, PPARG
1310.5PPP1R3A, INSR, IRS1, AKT2, ENPP1, SLC2A4
14
Show member pathways
Signal transduction PTEN pathway59
10.5AKT2, TCF7L2, IRS1
15
Show member pathways
Transcription Receptor mediated HIF regulation59
Development CNTF receptor signaling59
Class IB PI3K non-lipid kinase events37
ErbB2/ErbB3 signaling events37
Development Growth hormone signaling via PI3K AKT and MAPK cascades59
Translation Regulation activity of EIF259
Regulation of lipid metabolism Insulin signaling generic cascades59
Transcription PPAR Pathway59
Cell adhesion PLAU signaling59
Translation Regulation activity of EIF4F59
10.5PPARG, PPP1R3A, INSR, IRS1, AKT2, SLC2A4
1610.5HNF4A, AKT2, PPARG
1710.5ABCC8, KCNJ11, HNF4A, SLC2A2
18
Show member pathways
10.5AKT2, INSR, PPP1R3A, PPARG
19
Show member pathways
10.5AKT2, IRS1, INSR
20
Show member pathways
Insulin Pathway37
10.5INSR, IRS1, AKT2
21
Show member pathways
10.5ABCC8, KCNJ11, GCGR, SLC2A2
22
Show member pathways
10.5SLC2A4, AKT2, IRS1, INSR
23
Show member pathways
IL-9 Signaling Pathway37
Development Thrombopoietin regulated cell processes59
IL-7 Signaling Pathway37
Immune response IL 9 signaling pathway59
10.5SLC2A4, AKT2, IRS1, INSR
24
Show member pathways
10.5INSR, IRS1, AKT2, SLC2A4
25
Show member pathways
10.5INSR, IRS1, AKT2, MAPK8IP1, SLC2A4
26
Show member pathways
PLK2 and PLK4 events37
Polo-like kinase signaling events in the cell cycle37
10.5INSR, IRS1, AKT2, SLC2A4
27
Show member pathways
10.5ABCC8, KCNJ11, SLC2A2
2810.5SLC2A4, HNF4A, AKT2, INSR
29
Show member pathways
Prolactin Signaling Pathway37
Development Prolactin receptor signaling59
Leptin signaling pathway37
10.5IRS1, AKT2, SLC2A2
30
Show member pathways
10.5INSR, NEUROD1, HNF4A, SLC2A2
3110.5PPARG, IRS1, SLC2A4
3210.5SLC2A4, AKT2, IRS1
3310.5PPP1R3A, INSR, AKT2, SLC2A4
34
Show member pathways
10.5CAPN10, AKT2, INSR
35
Show member pathways
10.5PPP1R3A, INSR, IRS1, SLC2A4
3610.5HNF4A, SLC2A4, SLC2A2

Compounds for genes affiliated with Type 2 Diabetes Mellitus

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Compounds related to Type 2 Diabetes Mellitus according to GeneCards/GeneDecks:

(show top 50)    (show all 87)
idCompoundScoreTop Affiliating Genes
1glucose4411.0CAPN10, HNF1B, HNF4A, GCGR, ENPP1, SLC2A2
2glycogen44 2512.0PPP1R3A, ENPP1, GCGR, INSR, HNF4A, CAPN10
3repaglinide50 44 1213.0NEUROD1, PAX4, KCNJ11, TCF7L2, ABCC8, PPARG
4metformin44 50 1213.0SLC2A4, ENPP1, IRS1, INSR, KCNJ11, ABCC8
5lipid4411.0PPP1R3A, AKT2, CAPN10, TCF7L2, HNF4A, ENPP1
6glimepiride44 50 1212.9PPARG, SLC2A4, INSR, KCNJ11, ABCC8
7c-peptide4410.9KCNJ11, INSR, IRS1, SLC2A2, HNF4A
8fatty acid4410.9SLC2A4, ENPP1, GCGR, HNF4A, IRS1, ABCC8
9arginine4410.9HNF1B, HNF4A, IRS1, ABCC8, SLC2A2, KCNJ11
10sulfonylurea4410.9SLC2A2, SLC2A4, IRS1, KCNJ11, ABCC8
112-deoxyglucose44 1211.9PPARG, PPP1R3A, INSR, SLC2A2, SLC2A4, IRS1
12rapamycin4410.9AKT2, ENPP1, IRS1, INSR, PPARG, SLC2A4
13gliclazide44 50 1212.9SLC2A4, ABCC8, KCNJ11, INSR
14ly2940024410.9SLC2A4, IRS1, AKT2, INSR, TCF7L2, PPARG
15palmitate4410.9HNF4A, IRS1, INSR, PPARG, SLC2A4
16testosterone44 60 25 1213.9TCF7L2, HNF4A, PPARG, ABCC8, SLC2A4, INSR
17ibmx44 60 2912.9IRS1, INSR, SLC2A4, PPARG, SLC2A2
183-o-methylglucose4410.9SLC2A2, SLC2A4, INSR
19phosphatidylinositol4410.9AKT2, TCF7L2, IRS1, HNF4A, INSR, SLC2A4
20sterol4410.9HNF4A, SLC2A4, SLC2A2, IRS1, PPARG
21glycerol44 25 1212.9PPARG, INSR, IRS1, SLC2A4, HNF4A
22streptozotocin4410.9SLC2A4, IRS1, INSR, SLC2A2
23threonine4410.9AKT2, ENPP1, MAPK8IP1, SLC2A4, IRS1, INSR
24glibenclamide44 29 50 6013.9ABCC8, KCNJ11, INSR, SLC2A4
25vanadium4410.9IRS1, SLC2A4, INSR
26phosphoenolpyruvate44 1211.9SLC2A4, HNF4A, IRS1, SLC2A2
27atp44 2911.9ENPP1, KCNJ11, GCGR, MAPK8IP1, HNF4A, SLC2A2
28sb 20358044 6011.9AKT2, INSR, PPARG, IRS1, SLC2A4
29serine4410.9HNF4A, ENPP1, SLC2A4, AKT2, IRS1, INSR
30pioglitazone29 44 50 1213.9INSR, PPARG, SLC2A4, IRS1
31calcium44 50 25 1213.8MAPK8IP1, GCGR, HNF4A, CAPN10, NEUROD1, GPD2
32rosiglitazone29 44 50 25 1214.8SLC2A4, INSR, IRS1, PPARG
33troglitazone44 29 60 1213.8IRS1, INSR, SLC2A4, PPARG
34cibenzoline4410.8KCNJ11, ABCC8
35dexamethasone44 50 29 1213.8HNF4A, INSR, ENPP1, PPARG, SLC2A4, IRS1
36potassium44 25 1212.8IRS1, KCNJ11, ABCC8, CAPN10, SLC2A2
37katp4410.8SLC2A2, KCNJ11, ABCC8
38thiazolidinedione4410.8SLC2A4, IRS1, PPARG
39indinavir44 50 1212.7PPARG, IRS1, SLC2A4
40glutamine4410.7INSR, ENPP1, PPARG, KCNJ11, HNF4A
41sulfonamides, urea derivatives5010.7TCF7L2, KCNJ11
42sulindac44 1211.7TCF7L2, HNF4A, PPARG
43aicar44 25 1212.7SLC2A4, PPARG, INSR
44phenylarsine oxide4410.6INSR, IRS1, SLC2A4
45[3h]2-deoxyglucose2910.6SLC2A2, SLC2A4
46pyruvate4410.6SLC2A2, SLC2A4, HNF4A, GPD2
47leucine4410.5SLC2A2, ABCC8, KCNJ11, MAPK8IP1, HNF4A
48fructose44 1211.5SLC2A4, GCGR, SLC2A2
49mitiglinide44 1211.4ABCC8, PPARG
50glycerol 3-phosphate44 2511.2PPARG, SLC2A4, GPD2

GO Terms for genes affiliated with Type 2 Diabetes Mellitus

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Cellular components related to Type 2 Diabetes Mellitus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:00588710.5INSR, GCGR, ENPP1, SLC2A4, SLC2A2, KCNJ11
2insulin receptor complexGO:00589910.4IRS1, INSR
3plasma membraneGO:00588610.2ABCC8, KCNJ11, INSR, IRS1, AKT2, CAPN10

Biological processes related to Type 2 Diabetes Mellitus according to GeneCards/GeneDecks:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1glucose homeostasisGO:04259310.9SLC2A4, PPARG, INSR, NEUROD1, IRS1, TCF7L2
2cellular response to insulin stimulusGO:03286910.9PPARG, INSR, IRS1, AKT2, CAPN10, ENPP1
3endocrine pancreas developmentGO:03101810.9PAX4, NEUROD1, HNF1B, HNF4A, SLC2A2
4regulation of insulin secretionGO:05079610.9ABCC8, KCNJ11, NEUROD1, HNF4A, SLC2A2
5response to glucoseGO:00974910.8NEUROD1, TCF7L2, HNF1B, HNF4A
6positive regulation of glucose importGO:04632610.8CAPN10, AKT2, IRS1, INSR
7positive regulation of transcription from RNA polymerase II promoterGO:04594410.8PPARG, NEUROD1, TCF7L2, TCF4, HNF1B, HNF4A
8positive regulation of glycogen biosynthetic processGO:04572510.8AKT2, IRS1, INSR
9small molecule metabolic processGO:04428110.8ABCC8, KCNJ11, GPD2, GCGR, ENPP1, SLC2A4
10energy reserve metabolic processGO:00611210.8ABCC8, KCNJ11, GCGR, SLC2A2
11positive regulation of transcription, DNA-templatedGO:04589310.8PPARG, NEUROD1, TCF4, HNF1B, HNF4A
12positive regulation of glucose import in response to insulin stimulusGO:200127510.8IRS1, AKT2
13negative regulation of type B pancreatic cell apoptotic processGO:200067510.8NEUROD1, TCF7L2
14regulation of cell cycle arrestGO:07115610.7NEUROD1, AKT2
15positive regulation of glucose metabolic processGO:01090710.7AKT2, IRS1
16response to drugGO:04249310.7PPARG, KCNJ11, PAX4, NEUROD1
17positive regulation of fatty acid beta-oxidationGO:03200010.7AKT2, IRS1
18carbohydrate metabolic processGO:00597510.7SLC2A2, SLC2A4, INSR, ABCC8
19negative regulation of cell growthGO:03030810.7PPARG, HNF4A, ENPP1
20lipid homeostasisGO:05508810.6HNF4A, PPARG
21embryonic digestive tract morphogenesisGO:04855710.6TCF7L2, HNF1B
22insulin receptor signaling pathwayGO:00828610.5AKT2, IRS1, INSR
23negative regulation of insulin secretionGO:04667610.5IRS1, KCNJ11
24signal transduction involved in regulation of gene expressionGO:02301910.4NEUROD1, HNF4A
25negative regulation of insulin receptor signaling pathwayGO:04662710.2ENPP1, IRS1

Molecular functions related to Type 2 Diabetes Mellitus according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1sequence-specific DNA bindingGO:04356510.7HNF4A, HNF1B, TCF7L2, NEUROD1, PAX4, PPARG
2sequence-specific DNA binding transcription factor activityGO:00370010.6PPARG, PAX4, NEUROD1, TCF7L2, TCF4, HNF1B
3D-glucose transmembrane transporter activityGO:05505610.5SLC2A2, SLC2A4
4transcription regulatory region DNA bindingGO:04421210.5PPARG, TCF7L2, HNF1B, HNF4A
5phosphatidylinositol 3-kinase bindingGO:04354810.5IRS1, INSR
6protein bindingGO:00551510.5PPARG, INSR, NEUROD1, IRS1, TCF7L2, TCF4
7insulin-like growth factor receptor bindingGO:00515910.2IRS1, INSR

Products for genes affiliated with Type 2 Diabetes Mellitus

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Sources for Type 2 Diabetes Mellitus

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
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40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet