NIDDM
MCID: TYP009
MIFTS: 93

Type 2 Diabetes Mellitus (NIDDM) malady

Endocrine diseases category

Summaries for Type 2 Diabetes Mellitus

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8Disease Ontology, 63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 Diabetes mellitus type more...

MalaCards: Type 2 Diabetes Mellitus, also known as diabetes mellitus, non-insulin-dependent, is related to diabetes mellitus and obesity. An important gene associated with Type 2 Diabetes Mellitus is KCNJ11 (potassium inwardly-rectifying channel, subfamily J, member 11), and among its related pathways are IRS activation and Endometrial cancer. The drugs insulin and insulin, aspart, human and the compounds "sulfonamides, urea derivatives" and repaglinide have been mentioned in the context of this disorder. Affiliated tissues include endothelial, heart and bone, and related mouse phenotypes are endocrine/exocrine gland and adipose tissue.

Disease Ontology:8 A diabetes mellitus that involves high blood glucose resulting from cells fail to use insulin properly.

Description from OMIM:46 125853

Aliases & Classifications for Type 2 Diabetes Mellitus

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8Disease Ontology, 10DISEASES, 30LifeMap Discovery™, 44Novoseek, 22GTR, 46OMIM, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH, 25ICD10
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Related Diseases for Type 2 Diabetes Mellitus

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17GeneCards, 18GeneDecks
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Diseases in the Type 2 Diabetes Mellitus family:

Type 1 Diabetes Mellitus Diabetes Mellitus

Diseases related to Type 2 Diabetes Mellitus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 259)
idRelated DiseaseScoreTop Affiliating Genes
1diabetes mellitus32.6KCNJ11, HNF4A, ENPP1, PAX4, TCF7L2, SLC2A4
2obesity31.7KCNJ11, HNF4A, IRS1, INSR, SLC2A4, ENPP1
3hypertension31.5INSR
4coronary artery disease31.3IRS1, INSR, ENPP1
5atherosclerosis31.2HNF4A, IRS1, TCF7L2, ENPP1
6hepatitis31.0HNF4A
7hyperglycemia31.0ENPP1, PAX4, SLC2A4, INSR, IRS1, HNF1B
8hypoglycemia30.9KCNJ11, HNF4A, INSR, SLC2A4
9myocardial infarction30.9ENPP1
10ischemia30.8SLC2A4, INSR
11glucose intolerance30.8INSR, SLC2A4, PAX4, ENPP1
12insulinoma30.7PAX4, INSR, HNF4A, KCNJ11
13schizophrenia30.7INSR
14polycystic ovary syndrome30.7INSR, IRS1
15liver cirrhosis30.6SLC2A4, INSR, IRS1
16essential hypertension30.6INSR
17maturity-onset diabetes of the young30.5PAX4, HNF1B, HNF4A, KCNJ11
18acanthosis nigricans30.4INSR
19hyperinsulinism30.4INSR, IRS1, KCNJ11
20lipodystrophy30.4AKT2, INSR
21gestational diabetes30.4KCNJ11, HNF4A, IRS1, INSR, SLC2A4, TCF7L2
22hypertriglyceridemia30.2IRS1, INSR, SLC2A4
23hyperinsulinemic hypoglycemia30.2KCNJ11
24metabolic syndrome x30.2SLC2A4
25neonatal diabetes mellitus30.2KCNJ11, HNF1B
26leukemia30.2TCF4, PPP1R3A, IRS1
27polycystic kidney disease30.2ENPP1, HNF1B
28adenoma30.2TCF7L2, INSR, HNF4A
29stomach cancer30.1HNF4A, PPP1R3A, SLC2A4, TCF4, TCF7L2
30breast cancer30.1HNF4A, IRS1, AKT2, INSR, SLC2A4, TCF7L2
31type 1 diabetes mellitus11.1
32diabetic nephropathy11.0
33diabetic neuropathy10.9
34neuropathy10.9
35diabetic retinopathy10.9
36diabetic autonomic neuropathy10.7
37autonomic neuropathy10.7
38peripheral neuropathy10.7
39pancreatitis10.7
40periodontitis10.7
41vascular disease10.7
42alzheimer's disease10.7
43kidney disease10.7
44fatty liver disease10.6
45liver disease10.6
46lactic acidosis10.6
47hypogonadism10.6
48hypertensive heart disease10.5
49peripheral vascular disease10.5
50tuberculosis10.5

Graphical network of the top 20 diseases related to Type 2 Diabetes Mellitus:



Diseases related to type 2 diabetes mellitus

Clinical Features for Type 2 Diabetes Mellitus

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46OMIM
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Clinical features from OMIM:

125853

Drugs & Therapeutics for Type 2 Diabetes Mellitus

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Type 2 Diabetes Mellitus

Drug clinical trials:

Search ClinicalTrials for Type 2 Diabetes Mellitus

Search NIH Clinical Center for Type 2 Diabetes Mellitus

Highlights from CenterWatch's Drugs in Clinical Trials Database for Type 2 Diabetes Mellitus:

idCompanyCompoundMechanismPhase
1PhaseBio PharmaceuticalsGlymeraA long acting GLP-1 analogIIb
2RochealeglitazarA PPAR alpha and gamma modulatorII and III
3Boehringer Ingelheim/Eli LillyempagliflozinA SGLT-2 inhibitorIII
4Gilead SciencesranolazineA pFOX inhibitorIII
5Zealand PharmalixisenatideA glucagon-like peptide 1 receptor agonistIII

Inferred drug relations via UMLS60/NDF-RT40:

Show with subtypes

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Type 2 Diabetes Mellitus cell therapies at LifeMap Discovery.

Genetic Tests for Type 2 Diabetes Mellitus

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22GTR
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Genetic tests related to Type 2 Diabetes Mellitus:

id Genetic test Affiliating Genes
1 Diabetes Mellitus Type 222

Anatomical Context for Type 2 Diabetes Mellitus

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30LifeMap Discovery™, 32MalaCards
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MalaCards organs/tissues related to Type 2 Diabetes Mellitus:

32
Endothelial, Heart, Bone, Liver, Monocytes, Kidney, Skeletal muscle, Testes, Thyroid, Adipocyte, Ovary, T cells, Brain, Pancreatic islet, B cells, Lung, Pituitary, Breast, Pancreas, Skin, Eye, Pons, Spleen, Retina, Smooth muscle, Colon, Myeloid, Prostate, Bone marrow

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Type 2 Diabetes Mellitus:
id TissueAnatomical CompartmentCell Relevance
1 PancreasIslets of LangerhansMature Beta Cells Potential therapeutic candidate, affected by disease
2 AdiposeSubcutaneous White AdiposeMesenchymal Stem Cells Potential therapeutic candidate
3 AdiposeSubcutaneous White AdiposeStromal Cells Potential therapeutic candidate

Animal Models for Type 2 Diabetes Mellitus or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Type 2 Diabetes Mellitus:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.5KCNJ11, HNF1B, IRS1, SLC2A4
2MP:00053757.1KCNJ11, IRS1, PPP1R3A, AKT2, INSR, SLC2A4
3MP:00053877.0IRS1, AKT2, INSR, SLC2A4, TCF4, ENPP1
4MP:00053706.8HNF4A, HNF1B, IRS1, AKT2, INSR, SLC2A4
5MP:00036316.6KCNJ11, HNF4A, AKT2, INSR, SLC2A4, TCF4
6MP:00053696.5KCNJ11, HNF1B, IRS1, PPP1R3A, AKT2, INSR
7MP:00053765.9KCNJ11, HNF4A, HNF1B, IRS1, PPP1R3A, AKT2
8MP:00107685.8KCNJ11, HNF4A, HNF1B, IRS1, AKT2, INSR
9MP:00053785.4ENPP1, KCNJ11, HNF4A, HNF1B, IRS1, PPP1R3A

Publications for Type 2 Diabetes Mellitus

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50PubMed
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Articles related to Type 2 Diabetes Mellitus:

(show top 50)    (show all 2390)
idTitleAuthorsYear
1
Postprandial Glycemic Control Conditions in Relation to Urinary N-Acetyl-I^-d-Glucosaminidase in Patients with Type 2 Diabetes Mellitus Without Low Glomerular Filtration Rate. (24111861)
2014
2
Alogliptin: A new dipeptidyl peptidase-4 inhibitor for the management of type 2 diabetes mellitus. (24375601)
2014
3
The TNF-alpha -308G/A polymorphism is associated with type 2 diabetes mellitus: an updated meta-analysis. (24197696)
2014
4
Association between Telomere Length and Type 2 Diabetes Mellitus: A Meta-Analysis. (24278229)
2013
5
Meta-analysis of associations between TCF7L2 polymorphisms and risk of type 2 diabetes mellitus in the Chinese population. (23311683)
2013
6
Relationship between coronary artery disease and retinopathy in patients with type 2 diabetes mellitus. (24240785)
2013
7
The effect of oilseed consumption on appetite and on the risk of developing type 2 diabetes mellitus. (23822678)
2013
8
Type 2 diabetes mellitus coincident with pulmonary tuberculosis is associated with heightened systemic type 1, type 17, and other proinflammatory cytokines. (23987505)
2013
9
T2D@ZJU: a knowledgebase integrating heterogeneous connections associated with type 2 diabetes mellitus. (23846596)
2013
10
Association between PRO12ALA polymorphism of the PPAR-I^2 gene and type 2 diabetes mellitus in Iranian patients. (24019628)
2013
11
myo-Inositol supplementation and onset of gestational diabetes mellitus in pregnant women with a family history of type 2 diabetes: a prospective, randomized, placebo-controlled study. (23340885)
2013
12
Effects of green tea or green tea extract on insulin sensitivity and glycaemic control in populations at risk of type 2 diabetes mellitus: a systematic review and meta-analysis of randomised controlled trials. (24206044)
2013
13
Pharmacologic treatment strategies in children with type 2 diabetes mellitus. (23966754)
2013
14
Plasma adrenomedullin and subclinical cardiorenal syndrome in patients with type 2 diabetes mellitus. (22971508)
2012
15
Association of the type 2 diabetes mellitus susceptibility gene, TCF7L2, with schizophrenia in an Arab-Israeli family sample. (22247771)
2012
16
The burden of hypoglycemia on healthcare utilization, costs, and quality of life among type 2 diabetes mellitus patients. (22699113)
2012
17
Association of RAGE gene polymorphisms with type 2 diabetes mellitus, diabetic retinopathy and diabetic nephropathy. (22475522)
2012
18
Islet amyloid polypeptide gene variation (IAPP) and the risk of incident type 2 diabetes mellitus: the Women's Genome Health Study. (21219896)
2011
19
Association between polymorphisms of the DNA repair genes XRCC1 and hOGG1 and type 2 diabetes mellitus in the Polish population. (19514640)
2009
20
Effect of PPAR-gamma agonist treatment on markers of endothelial dysfunction in patients with type 2 diabetes mellitus. (17087601)
2007
21
Incretin strategy in the treatment of type 2 diabetes mellitus--DPPIV]. (18019673)
2007
22
Efficacy of a pedometer-based physical activity program on parameters of diabetes control in type 2 diabetes mellitus. (16979410)
2006
23
Alanine aminotransferase as a marker of non-alcoholic fatty liver disease in relation to type 2 diabetes mellitus and cardiovascular disease. (16832839)
2006
24
Influences of statins on glucose tolerance in patients with type 2 diabetes mellitus. (16733297)
2006
25
Effects of 1 year of treatment with pioglitazone or rosiglitazone added to glimepiride on lipoprotein (a) and homocysteine concentrations in patients with type 2 diabetes mellitus and metabolic syndrome: a multicenter, randomized, double-blind, controlled clinical trial. (16861090)
2006
26
Variants of calpain-10 gene and its association with type 2 diabetes mellitus in a Chinese population. (15860244)
2005
27
Genetic variations in the gene encoding TFAP2B are associated with type 2 diabetes mellitus. (15940393)
2005
28
Paraoxonase 1 Gln/Arg polymorphism is associated with the risk of microangiopathy in Type 2 diabetes mellitus. (15270786)
2004
29
A common functional variant in the interleukin-6 gene is associated with increased body mass index in subjects with type 2 diabetes mellitus. (15172007)
2004
30
Multifactor-dimensionality reduction shows a two-locus interaction associated with Type 2 diabetes mellitus. (14730379)
2004
31
Usefulness of miglitol in patients with diabetes mellitus type 2 and insufficient control of the blood glucose]. (14746760)
2004
32
Erythropoietin requirement in patients with type 2 diabetes mellitus on maintenance hemodialysis therapy. (15690969)
2004
33
C-reactive protein and risk factors for peripheral vascular disease in subjects with Type 2 diabetes mellitus. (15049935)
2004
34
Association of a promoter variant in the inducible cyclooxygenase-2 gene (PTGS2) with type 2 diabetes mellitus in Pima Indians. (12920574)
2003
35
A study to survey susceptible genetic factors responsible for troglitazone-associated hepatotoxicity in Japanese patients with type 2 diabetes mellitus. (12732844)
2003
36
Effects of the prostaglandin I2 analogue, beraprost sodium, on vascular cell adhesion molecule-1 expression in human vascular endothelial cells and circulating vascular cell adhesion molecule-1 level in patients with type 2 diabetes mellitus. (12601631)
2003
37
Peripheral arterial disease in diabetes mellitus type 1 and type 2: are there different risk factors? (12510549)
2002
38
Metabolic and haemodynamic effects of metformin in patients with type 2 diabetes mellitus and hypertension. (11703421)
2001
39
Cardiovascular risk factors and LDL subfraction profile in Type 2 diabetes mellitus subjects with good glycaemic control. (11165690)
2001
40
Association between angiotensin-II receptor gene type I polymorphism and diabetic nephropathy in type 2 diabetes mellitus]. (11798574)
2001
41
Amylin replacement with pramlintide as an adjunct to insulin therapy in type 1 and type 2 diabetes mellitus: a physiological approach toward improved metabolic control. (11472273)
2001
42
Increased intracellular generation of reactive oxygen species in mononuclear leukocytes from patients with diabetes mellitus type 2. (10926312)
2000
43
Molecular scanning for mutations in the insulin receptor substrate-1 (IRS-1) gene in Mexican Americans with Type 2 diabetes mellitus. (11025561)
2000
44
Role of the allelic E4 variant of apolipoprotein E in lipid concentrations in a Mexican rural indigenous population predisposed to type 2 diabetes mellitus]. (10953615)
2000
45
Left ventricular mass in type 2 diabetes mellitus. A study employing a simple ECG index: the Cornell voltage. (10803469)
2000
46
Relationships of angiotensinogen gene M235T variant with diabetic nephropathy in Chinese type 2 diabetes mellitus]. (10514536)
1999
47
Short-term efficacy and tolerability of combination therapy with lovastatin and acipimox in Chinese patients with type 2 diabetes mellitus and mixed dyslipidemia. (9807971)
1998
48
Urinary angiotensin-converting enzyme activity in type 2 diabetes mellitus: its relationship to diabetic nephropathy. (8590790)
1995
49
Mutations in the glucokinase gene are not a major cause of late-onset type 2 (non-insulin-dependent) diabetes mellitus in Japanese subjects. (8200206)
1994
50
Insulin treatment improves microalbuminuria and other cardiovascular risk factors in patients with type 2 diabetes mellitus. (8120522)
1994

Genetic Variations for Type 2 Diabetes Mellitus

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62UniProtKB/Swiss-Prot
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Genetic disease variations for Type 2 Diabetes Mellitus:

62 (show all 33)
id Symbol AA change Variation ID SNP ID
1AKT2p.Arg274HisVAR_067310
2AKT2p.Arg274HisVAR_067310
3AKT2p.Arg274HisVAR_067310
4HNF1Bp.Ser465ArgVAR_017665
5HNF1Bp.Ser465ArgVAR_017665
6HNF1Bp.Ser465ArgVAR_017665
7HNF4Ap.Val402IleVAR_004670rs137853337
8HNF4Ap.Val402IleVAR_004670rs137853337
9HNF4Ap.Val402IleVAR_004670rs137853337
10INSRp.Arg1191GlnVAR_004098
11INSRp.Arg1191GlnVAR_004098
12INSRp.Arg1191GlnVAR_004098
13INSRp.Thr858AlaVAR_015917rs182552223
14INSRp.Thr858AlaVAR_015917rs182552223
15INSRp.Thr858AlaVAR_015917rs182552223
16INSRp.Arg1158GlnVAR_015927
17INSRp.Arg1158GlnVAR_015927
18INSRp.Arg1158GlnVAR_015927
19IRS1p.Ser1043TyrVAR_005302
20IRS1p.Ser1043TyrVAR_005302
21IRS1p.Ser1043TyrVAR_005302
22IRS1p.Cys1095TyrVAR_005303
23IRS1p.Cys1095TyrVAR_005303
24IRS1p.Cys1095TyrVAR_005303
25MAPK8IP1p.Ser59AsnVAR_012243
26MAPK8IP1p.Ser59AsnVAR_012243
27MAPK8IP1p.Ser59AsnVAR_012243
28PPP1R3Ap.Ala931GluVAR_019699rs35449651
29PPP1R3Ap.Ala931GluVAR_019699rs35449651
30PPP1R3Ap.Ala931GluVAR_019699rs35449651
31SLC2A4p.Val383IleVAR_007170rs121434581
32SLC2A4p.Val383IleVAR_007170rs121434581
33SLC2A4p.Val383IleVAR_007170rs121434581

Expression for genes affiliated with Type 2 Diabetes Mellitus

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Type 2 Diabetes Mellitus

Search GEO for disease gene expression data for Type 2 Diabetes Mellitus.

Pathways for genes affiliated with Type 2 Diabetes Mellitus

About this section
Sources:
53Reactome, 29KEGG, 12EMD Millipore, 37NCBI BioSystems Database, 51QIAGEN, 59Tocris Bioscience, 52R&D Systems, 4Cell Signaling Technology, 49PharmGKB
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Pathways related to Type 2 Diabetes Mellitus according to GeneCards/GeneDecks:

(show all 29)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.4INSR, IRS1
2
Hide members
9.4TCF7L2, AKT2, IRS1
3
Hide members
9.4TCF7L2, AKT2, IRS1
49.3TCF7L2, TCF4, HNF4A
59.3SLC2A4, AKT2
6
Hide members
9.1INSR, AKT2, PPP1R3A
7
Hide members
9.0IRS1, AKT2, INSR
8
Development Ligand-independent activation of ESR1 and ESR2
Hide members
9.0IRS1, AKT2, INSR
99.0INSR, AKT2, IRS1
10
Hide members
9.0SLC2A4, TCF4, PAX4
11
Hide members
9.0HNF4A, AKT2, TCF4, TCF7L2
128.8IRS1, AKT2, SLC2A4
13
Hide members
8.8PAX4, AKT2, HNF1B, HNF4A
14
Hide members
8.7IRS1, AKT2, INSR, TCF7L2
15
Development Leptin signaling via PI3K-dependent pathway
Hide members
8.6KCNJ11, IRS1, AKT2, SLC2A4
168.2PPP1R3A, AKT2, INSR, SLC2A4
17
Hide members
8.2IRS1, AKT2, INSR, SLC2A4
18
Hide members
8.2IRS1, AKT2, INSR, SLC2A4
198.2SLC2A4, INSR, AKT2, IRS1
20
Hide members
8.2SLC2A4, INSR, AKT2, IRS1
21
Hide members
8.2SLC2A4, INSR, PPP1R3A, IRS1
228.1SLC2A4, INSR, AKT2, HNF4A
23
Hide members
8.1TCF7L2, TCF4, SLC2A4, AKT2, HNF4A
24
Hide members
7.9HNF4A, IRS1, AKT2, INSR, TCF4, TCF7L2
25
Translation Insulin regulation of translation
Hide members
7.8IRS1, PPP1R3A, AKT2, INSR, SLC2A4
267.5IRS1, PPP1R3A, AKT2, INSR, SLC2A4, ENPP1
27
Hide members
7.5HNF4A, IRS1, PPP1R3A, AKT2, INSR, TCF4
287.4HNF4A, IRS1, AKT2, INSR, SLC2A4, ENPP1
29
Hide members
7.3SLC2A4, INSR, IRS1, HNF1B, HNF4A, KCNJ11

Compounds for genes affiliated with Type 2 Diabetes Mellitus

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49PharmGKB, 44Novoseek, 11DrugBank, 28IUPHAR, 59Tocris Bioscience, 24HMDB
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Compounds related to Type 2 Diabetes Mellitus according to GeneCards/GeneDecks:

(show top 50)    (show all 53)
idCompoundScoreTop Affiliating Genes
1sulfonamides, urea derivatives4910.3KCNJ11, TCF7L2
2repaglinide44 49 1112.1TCF7L2, KCNJ11, PAX4
3mononucleotide449.9TCF4, TCF7L2
4[4-({5-(AMINOCARBONYL)-4-[(3-METHYLPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENYL]ACETIC ACID119.8IRS1, INSR
5vanadyl sulfate449.7INSR, IRS1
6ag 1024449.7INSR, IRS1
7moxonidine449.7IRS1, INSR
83-o-methylglucose449.4SLC2A4, INSR
9grp-1449.4SLC2A4, INSR
10sulfonylurea449.3IRS1, SLC2A4, KCNJ11
112,4-dinitrophenol449.3SLC2A4, IRS1
12glimepiride44 49 1111.2INSR, SLC2A4, KCNJ11
13gliclazide44 49 1111.2KCNJ11, SLC2A4, INSR
14glibenclamide44 28 49 5912.1KCNJ11, INSR, SLC2A4
15phosphoenolpyruvate44 1110.1SLC2A4, HNF4A, IRS1
16c-peptide449.0KCNJ11, HNF4A, INSR, IRS1
17vanadium449.0IRS1, INSR, SLC2A4
18glutamine449.0INSR, KCNJ11, ENPP1, HNF4A
19phenylarsine oxide449.0IRS1, SLC2A4, INSR
20streptozotocin449.0INSR, SLC2A4, IRS1
21glucosamine44 11 2411.0SLC2A4, INSR, IRS1
22pioglitazone44 49 28 1111.9INSR, IRS1, SLC2A4
23anisomycin44 119.9SLC2A4, INSR, IRS1
24rosiglitazone44 49 28 11 2412.8INSR, IRS1, SLC2A4
25phosphatidylinositol-3,4,5-trisphosphate44 249.8SLC2A4, INSR, IRS1
26troglitazone44 28 59 1111.8IRS1, INSR, SLC2A4
27ibmx44 28 5910.7SLC2A4, INSR, IRS1
28okadaic acid44 599.7SLC2A4, IRS1, HNF4A
292-deoxyglucose44 119.6IRS1, SLC2A4, INSR, PPP1R3A
30sterol448.6HNF4A, SLC2A4, IRS1
31sb 20358044 599.6AKT2, INSR, IRS1, SLC2A4
32fatty acid448.5HNF4A, IRS1, ENPP1, SLC2A4
33wortmannin448.5IRS1, SLC2A4, AKT2, INSR
34palmitate448.5HNF4A, INSR, IRS1, SLC2A4
35valine448.5INSR, KCNJ11, SLC2A4
36glycerol44 11 2410.5IRS1, INSR, SLC2A4, HNF4A
37metformin44 49 1110.4KCNJ11, IRS1, INSR, SLC2A4, ENPP1
38arginine448.4HNF1B, KCNJ11, INSR, IRS1, HNF4A
39pd 98,059448.4HNF4A, INSR, SLC2A4, IRS1
40ly294002448.3AKT2, SLC2A4, IRS1, TCF7L2, INSR
41rapamycin448.3ENPP1, IRS1, AKT2, INSR, SLC2A4
42testosterone44 59 11 2411.1TCF7L2, SLC2A4, INSR, HNF4A, IRS1
43dexamethasone44 49 28 1111.1HNF4A, IRS1, INSR, ENPP1, SLC2A4
44threonine447.8INSR, AKT2, IRS1, HNF4A, ENPP1, SLC2A4
45serine447.6ENPP1, INSR, HNF4A, AKT2, IRS1, SLC2A4
46phosphatidylinositol447.5TCF7L2, ENPP1, AKT2, IRS1, SLC2A4, HNF4A
47tyrosine447.4INSR, ENPP1, SLC2A4, AKT2, IRS1, HNF4A
48lipid447.1HNF4A, PPP1R3A, TCF7L2, INSR, SLC2A4, IRS1
49glycogen44 247.8ENPP1, HNF4A, PPP1R3A, AKT2, INSR, SLC2A4
50glucose446.4PAX4, TCF7L2, SLC2A4, PPP1R3A, IRS1, HNF1B

GO Terms for genes affiliated with Type 2 Diabetes Mellitus

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16Gene Ontology
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Cellular components related to Type 2 Diabetes Mellitus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transcription factor complexGO:0056679.3TCF7L2, TCF4, HNF1B
2insulin receptor complexGO:0058999.1INSR, IRS1

Biological processes related to Type 2 Diabetes Mellitus according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of fat cell differentiationGO:0455999.9ENPP1, TCF7L2
2positive regulation of glucose import in response to insulin stimulusGO:20012759.8IRS1, AKT2
3positive regulation of glucose metabolic processGO:0109079.8AKT2, IRS1
4positive regulation of fatty acid beta-oxidationGO:0320009.8AKT2, IRS1
5embryonic digestive tract morphogenesisGO:0485579.7TCF7L2, HNF1B
6negative regulation of insulin receptor signaling pathwayGO:0466279.6ENPP1, IRS1
7negative regulation of insulin secretionGO:0466769.5IRS1, KCNJ11
8endocrine pancreas developmentGO:0310189.4PAX4, HNF1B, HNF4A
9response to glucose stimulusGO:0097499.3TCF7L2, HNF1B, HNF4A
10positive regulation of glycogen biosynthetic processGO:0457259.3IRS1, AKT2, INSR
11positive regulation of glucose importGO:0463269.3INSR, AKT2, IRS1
12insulin receptor signaling pathwayGO:0082869.1IRS1, AKT2, INSR
13cellular response to insulin stimulusGO:0328698.2ENPP1, SLC2A4, INSR, AKT2, IRS1
14glucose homeostasisGO:0425938.0HNF4A, IRS1, INSR, SLC2A4, TCF7L2

Molecular functions related to Type 2 Diabetes Mellitus according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1RNA polymerase II core promoter proximal region sequence-specific DNA bindingGO:0009789.8TCF7L2, TCF4
2insulin-like growth factor receptor bindingGO:0051599.6INSR, IRS1
3insulin receptor bindingGO:0051589.6IRS1, ENPP1
4phosphatidylinositol 3-kinase bindingGO:0435489.5IRS1, INSR
5transcription regulatory region DNA bindingGO:0442129.2HNF4A, HNF1B, TCF7L2
6SH2 domain bindingGO:0421699.1INSR, IRS1
7sequence-specific DNA bindingGO:0435659.0PAX4, TCF7L2, HNF1B, HNF4A
8sequence-specific DNA binding transcription factor activityGO:0037008.7PAX4, TCF7L2, TCF4, HNF1B, HNF4A
9protein bindingGO:0055156.2HNF4A, HNF1B, IRS1, AKT2, INSR, SLC2A4

Products for genes affiliated with Type 2 Diabetes Mellitus

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Type 2 Diabetes Mellitus

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet