NIDDM
MCID: TYP009
MIFTS: 95

Type 2 Diabetes Mellitus (NIDDM) malady

Genetic diseases, Endocrine diseases, Rare diseases categories
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Summaries for Type 2 Diabetes Mellitus

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8Disease Ontology, 65Wikipedia, 47OMIM, 33MalaCards
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Wikipedia:65 Diabetes mellitus type more...

MalaCards: Type 2 Diabetes Mellitus, also known as diabetes mellitus, non-insulin-dependent, is related to diabetes mellitus and obesity. An important gene associated with Type 2 Diabetes Mellitus is KCNJ11 (potassium inwardly-rectifying channel, subfamily J, member 11), and among its related pathways are Incretin Synthesis, Secretion, and Inactivation and Endometrial cancer. The drugs acetohexamide and chlorpropamide and the compounds repaglinide and vanadium have been mentioned in the context of this disorder. Affiliated tissues include endothelial, heart and bone, and related mouse phenotypes are adipose tissue and muscle.

Disease Ontology:8 A diabetes mellitus that involves high blood glucose resulting from cells fail to use insulin properly.

Description from OMIM:47 125853

Aliases & Classifications for Type 2 Diabetes Mellitus

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8Disease Ontology, 22GTR, 47OMIM, 10DISEASES, 45Novoseek, 31LifeMap Discovery™, 62UMLS, 58SNOMED-CT, 35MeSH, 40NCIt, 25ICD10
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Related Diseases for Type 2 Diabetes Mellitus

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17GeneCards, 18GeneDecks
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Diseases in the Type 1 Diabetes Mellitus family:

Diabetes Mellitus type 2 diabetes mellitus

Diseases related to Type 2 Diabetes Mellitus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 270)
idRelated DiseaseScoreTop Affiliating Genes
1diabetes mellitus32.9PAX4, IRS1, TCF7L2, AKT2, HNF1B, HNF4A
2obesity32.0SLC2A4, HNF4A, IRS1, ENPP1, PPARGC1B, INSR
3insulin resistance31.8SLC2A4, IDE, INSR, PEA15, PPP1R3A, LEP
4coronary artery disease31.6IRS1, LEP, SHBG
5atherosclerosis31.5SHBG, IRS1, LEP, ENPP1, HNF4A, TCF7L2
6hyperglycemia31.3PAX4, IRS1, HNF1B, HNF4A, SLC2A4, KCNJ11
7hypoglycemia31.2KCNJ11, HNF4A, INSR, SLC2A4
8fatty liver disease31.2HNF4A, INSR, LEP
9glucose intolerance31.1SHBG, PAX4, INSR, LEP, ENPP1, IDE
10hypertriglyceridemia31.1SHBG, SLC2A4, LEP, INSR, IRS1
11insulinoma31.0KCNJ11, GPD2, INSR, PAX4, HNF4A
12polycystic ovary syndrome31.0SHBG, IRS1, LEP, INSR
13hyperandrogenism30.9SHBG, LEP, INSR
14liver cirrhosis30.9HNF4A, SLC2A4, INSR, IRS1
15essential hypertension30.9INSR, SHBG, LEP
16maturity-onset diabetes of the young30.8HNF4A, HNF1B, PAX4, KCNJ11
17type 1 diabetes mellitus30.8PAX4, HNF4A, LEP, INSR, ENPP1
18acanthosis nigricans30.7SHBG, LEP, INSR
19anovulation30.7SHBG, LEP
20hyperinsulinism30.7INSR, SHBG, IRS1, KCNJ11, LEP
21gestational diabetes30.7TCF7L2, SLC2A4, ENPP1, KCNJ11, INSR, LEP
22lipodystrophy30.6INSR, LEP, AKT2
23uremia30.5LEP, ENPP1, INSR
24hyperinsulinemic hypoglycemia30.5KCNJ11
25metabolic syndrome x30.5LEP, SLC2A4
26hypothyroidism30.4LEP, SHBG
27adenoma30.4HNF4A, TCF7L2, SHBG, INSR
28breast cancer30.4AKT2, SLC2A4, ENPP1, HNF4A, TCF7L2, IRS1
29stomach cancer30.3HNF4A, TCF4, SLC2A4, TCF7L2, PPP1R3A
30ovarian disease30.1INSR, SHBG
31hypertension11.1
32endotheliitis11.0
33artery disease11.0
34neuropathy11.0
35diabetic nephropathy10.9
36blindness10.9
37diabetic retinopathy10.8
38autonomic neuropathy10.8
39hepatitis10.7
40pancreatitis10.7
41periodontitis10.7
42peripheral neuropathy10.7
43alzheimer's disease10.7
44kidney disease10.7
45liver disease10.7
46myocardial infarction10.7
47vascular disease10.7
48ischemia10.6
49lactic acidosis10.6
50hypercholesterolemia10.6

Graphical network of the top 20 diseases related to Type 2 Diabetes Mellitus:



Diseases related to type 2 diabetes mellitus

Symptoms for Type 2 Diabetes Mellitus

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47OMIM
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Clinical features from OMIM:

125853

Drugs & Therapeutics for Type 2 Diabetes Mellitus

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Type 2 Diabetes Mellitus

Search NIH Clinical Center for Type 2 Diabetes Mellitus

Inferred drug relations via UMLS62/NDF-RT41:

Show with subtypes

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Type 2 Diabetes Mellitus cell therapies at LifeMap Discovery.

Genetic Tests for Type 2 Diabetes Mellitus

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22GTR
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Genetic tests related to Type 2 Diabetes Mellitus:

id Genetic test Affiliating Genes
1 Diabetes Mellitus Type 222

Anatomical Context for Type 2 Diabetes Mellitus

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31LifeMap Discovery™, 33MalaCards
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MalaCards organs/tissues related to Type 2 Diabetes Mellitus:

33
Endothelial, Heart, Bone, Liver, Kidney, Monocytes, Testes, Skeletal muscle, T cells, Adipocyte, Ovary, Brain, Thyroid, B cells, Pancreatic islet, Lung, Pituitary, Pancreas, Prostate, Retina, Skin, Myeloid, Breast, Colon, Smooth muscle, Bone marrow, Eye, Spleen, Pons

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Type 2 Diabetes Mellitus:
id TissueAnatomical CompartmentCell Relevance
1 PancreasIslets of LangerhansMature Beta Cells Potential therapeutic candidate, affected by disease
2 AdiposeSubcutaneous White AdiposeMesenchymal Stem Cells Potential therapeutic candidate
3 AdiposeSubcutaneous White AdiposeStromal Cells Potential therapeutic candidate

Animal Models for Type 2 Diabetes Mellitus or affiliated genes

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37MGI
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Publications for Type 2 Diabetes Mellitus

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52PubMed
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Articles related to Type 2 Diabetes Mellitus:

(show top 50)    (show all 2191)
idTitleAuthorsYear
1
Postprandial Glycemic Control Conditions in Relation to Urinary N-Acetyl-I^-d-Glucosaminidase in Patients with Type 2 Diabetes Mellitus Without Low Glomerular Filtration Rate. (24111861)
2014
2
Albuminuria and management of type 2 diabetes mellitus. (23880799)
2013
3
Baseline characteristics in the Bardoxolone methyl EvAluation in patients with Chronic kidney disease and type 2 diabetes mellitus: the Occurrence of renal eveNts (BEACON) trial. (24169612)
2013
4
Type 2 diabetes mellitus and invokana: an FDA approved drug. (24160357)
2013
5
The prevalence of orthostatic hypotension in type 2 diabetes mellitus patients in a diabetic clinic in Enugu South-East Nigeria. (24180143)
2013
6
Preliminary results of pinpoint plantar long-wavelength infrared light irradiation on blood glucose, insulin and stress hormones in patients with type 2 diabetes mellitus. (24204095)
2013
7
Lipids and lipoprotein ratios: contribution to carotid intima media thickness in adolescents and young adults with type 2 diabetes mellitus. (24079285)
2013
8
Genetic polymorphisms of the TLR4 gene and their association with susceptibility to type 2 diabetes mellitus in the Chinese population. (24085443)
2013
9
Diet and kidney disease in high-risk individuals with type 2 diabetes mellitus. (23939297)
2013
10
Comparative effect of angiotensin II type I receptor blockers on serum uric acid in hypertensive patients with type 2 diabetes mellitus: a retrospective observational study. (24180232)
2013
11
Prevalence and determinants of hyperuricemia in type 2 diabetes mellitus patients with central obesity in Guangdong Province in China. (24231020)
2013
12
The type 2 diabetes mellitus susceptibility gene IGF2BP2 is associated with schizophrenia in a Han Chinese population. (23656854)
2013
13
Plasma adrenomedullin and subclinical cardiorenal syndrome in patients with type 2 diabetes mellitus. (22971508)
2012
14
Plasma proprotein convertase subtilisin kexin type 9 is not altered in subjects with impaired glucose metabolism and type 2 diabetes mellitus, but its relationship with non-HDL cholesterol and apolipoprotein B may be modified by type 2 diabetes mellitus: The CODAM study. (21497351)
2011
15
Serum insulin-like growth factor-I is negatively associated with serum adiponectin in type 2 diabetes mellitus. (21839662)
2011
16
Heterogeneity of genetic associations of CDKAL1 and HHEX with susceptibility of type 2 diabetes mellitus by gender. (21368910)
2011
17
PON1 55 and 192 gene polymorphisms in type 2 diabetes mellitus patients in a Turkish population. (20820904)
2011
18
Lysosomal I^-galactosidase and I^-hexosaminidase activities correlate with clinical stages of dementia associated with Alzheimer's disease and type 2 diabetes mellitus. (21321400)
2011
19
Association of interleukin-4 promoter polymorphisms in Taiwanese patients with type 2 diabetes mellitus. (20580039)
2010
20
The role of IGF-1 resistance in obesity and type 2 diabetes-mellitus-related insulin resistance and vascular disease. (21058922)
2010
21
Exercise training ameliorates the effects of rosiglitazone on traditional and novel cardiovascular risk factors in patients with type 2 diabetes mellitus. (19922961)
2010
22
Oxidative stress and platelet activation: markers of myocardial infarction in type 2 diabetes mellitus. (19759031)
2010
23
Serum levels of proamylin and amylin in normal subjects and patients with impaired glucose regulation and type 2 diabetes mellitus. (20509034)
2010
24
Positive correlations of liver enzymes with metabolic syndrome including insulin resistance in newly diagnosed type 2 diabetes mellitus. (20972737)
2010
25
Plasma apolipoprotein M responses to statin and fibrate administration in type 2 diabetes mellitus. (20828695)
2010
26
Valsartan increases circulating adiponectin levels without changing HOMA-IR in patients with type 2 diabetes mellitus and hypertension. (20233535)
2010
27
Alterations of insulin resistance and the serum adiponectin level in patients with type 2 diabetes mellitus under the usual antihypertensive dosage of telmisartan treatment. (20388049)
2010
28
Pleiotropic effects of mitiglinide in type 2 diabetes mellitus. (20146890)
2009
29
Long-term pioglitazone therapy improves arterial stiffness in patients with type 2 diabetes mellitus. (19446110)
2009
30
Liraglutide: a once-daily incretin mimetic for the treatment of type 2 diabetes mellitus. (19638470)
2009
31
Miglitol increases the adiponectin level and decreases urinary albumin excretion in patients with type 2 diabetes mellitus. (17950094)
2007
32
The interactive role of type 2 diabetes mellitus and E-selectin S128R mutation on susceptibility to coronary heart disease. (17578587)
2007
33
Effects of carvedilol versus metoprolol on endothelial function and oxidative stress in patients with type 2 diabetes mellitus. (17586413)
2007
34
The common C49620T polymorphism in the sulfonylurea receptor gene (ABCC8), pancreatic beta cell function and long-term diabetic complications in obese patients with long-lasting type 2 diabetes mellitus. (17516295)
2007
35
Preventing macrovascular complications in type 2 diabetes mellitus: glucose control and beyond. (17665747)
2007
36
Influence of insulin therapy on expression of chemokine receptor CCR5 and selected inflammatory markers in patients with type 2 diabetes mellitus. (17966842)
2007
37
Recombinant human insulin-like growth factor-I treatment inhibits gluconeogenesis in a transgenic mouse model of type 2 diabetes mellitus. (16513827)
2006
38
The Leu7Pro polymorphism of neuropeptide Y is associated with younger age of onset of type 2 diabetes mellitus and increased risk for nephropathy in subjects with diabetic retinopathy. (16705546)
2006
39
Efficacy of a pedometer-based physical activity program on parameters of diabetes control in type 2 diabetes mellitus. (16979410)
2006
40
Long-term treatment with nifedipine modulates procoagulant marker and C-C chemokine in hypertensive patients with type 2 diabetes mellitus. (15668187)
2005
41
High serum interleukin-18 concentrations in patients with coronary artery disease and type 2 diabetes mellitus. (16266856)
2005
42
Atorvastatin: a review of its use in the primary prevention of cardiovascular events in patients with type 2 diabetes mellitus. (15610062)
2005
43
HMG-CoA reductase inhibitors prevent bone loss in patients with Type 2 diabetes mellitus. (15317608)
2004
44
Beneficial effects of triple drug combination of pioglitazone with glibenclamide and metformin in type 2 diabetes mellitus patients on insulin therapy. (15260389)
2003
45
Newer insulin therapies for management of type 1 and type 2 diabetes mellitus. (16563061)
2003
46
Plasma phospholipid transfer protein activity and small, dense LDL in type 2 diabetes mellitus. (12662160)
2003
47
Therapeutic options for the management of type 2 diabetes mellitus. (12437315)
2002
48
The human amylin analog, pramlintide, reduces postprandial hyperglucagonemia in patients with type 2 diabetes mellitus. (12384827)
2002
49
Analysis of slc19a2, on 1q23.3 encoding a thiamine transporter as a candidate gene for type 2 diabetes mellitus in pima indians. (11286512)
2001
50
A susceptibility locus for early-onset non-insulin dependent (type 2) diabetes mellitus maps to chromosome 20q, proximal to the phosphoenolpyruvate carboxykinase gene. (9285775)
1997

Variations for Type 2 Diabetes Mellitus

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Sources:
64UniProtKB/Swiss-Prot, 1 National Center for Biotechnology Information (Clinvar), 7dbSNP
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UniProtKB/Swiss-Prot genetic disease variations for Type 2 Diabetes Mellitus:

64 (show all 33)
id Symbol AA change Variation ID SNP ID
1AKT2p.Arg274HisVAR_067310
2AKT2p.Arg274HisVAR_067310
3AKT2p.Arg274HisVAR_067310
4HNF1Bp.Ser465ArgVAR_017665
5HNF1Bp.Ser465ArgVAR_017665
6HNF1Bp.Ser465ArgVAR_017665
7HNF4Ap.Val402IleVAR_004670rs137853337
8HNF4Ap.Val402IleVAR_004670rs137853337
9HNF4Ap.Val402IleVAR_004670rs137853337
10INSRp.Arg1191GlnVAR_004098
11INSRp.Arg1191GlnVAR_004098
12INSRp.Arg1191GlnVAR_004098
13INSRp.Thr858AlaVAR_015917rs182552223
14INSRp.Thr858AlaVAR_015917rs182552223
15INSRp.Thr858AlaVAR_015917rs182552223
16INSRp.Arg1158GlnVAR_015927
17INSRp.Arg1158GlnVAR_015927
18INSRp.Arg1158GlnVAR_015927
19IRS1p.Ser1043TyrVAR_005302
20IRS1p.Ser1043TyrVAR_005302
21IRS1p.Ser1043TyrVAR_005302
22IRS1p.Cys1095TyrVAR_005303
23IRS1p.Cys1095TyrVAR_005303
24IRS1p.Cys1095TyrVAR_005303
25MAPK8IP1p.Ser59AsnVAR_012243
26MAPK8IP1p.Ser59AsnVAR_012243
27MAPK8IP1p.Ser59AsnVAR_012243
28PPP1R3Ap.Ala931GluVAR_019699rs35449651
29PPP1R3Ap.Ala931GluVAR_019699rs35449651
30PPP1R3Ap.Ala931GluVAR_019699rs35449651
31SLC2A4p.Val383IleVAR_007170rs121434581
32SLC2A4p.Val383IleVAR_007170rs121434581
33SLC2A4p.Val383IleVAR_007170rs121434581

Clinvar genetic disease variations for Type 2 Diabetes Mellitus:

1 (show all 16)
id Gene Name Type Significance SNP ID Assembly Location
1HNF1BNM_000458.2(HNF1B): c.1395C> G (p.Ser465Arg)single nucleotide variantPathogenicrs121918673GRCh37Chr 17, 36061127: 36061127
2PAX4NM_006193.2(PAX4): c.361C> T (p.Arg121Trp)single nucleotide variantPathogenicrs114202595GRCh37Chr 7, 127254587: 127254587
3AKT2NM_001626.5(AKT2): c.821G> A (p.Arg274His)single nucleotide variantPathogenicrs121434593GRCh37Chr 19, 40743886: 40743886
4INSRNM_000208.2(INSR): c.3572G> A (p.Arg1191Gln)single nucleotide variantPathogenicrs121913150GRCh37Chr 19, 7120718: 7120718
5INSRNM_000208.2(INSR): c.3034G> A (p.Val1012Met)single nucleotide variantLikely pathogenic, Pathogenicrs1799816GRCh37Chr 19, 7125518: 7125518
6GPD2NM_001083112.2(GPD2): c.1904T> C (p.Phe635Ser)single nucleotide variantPathogenicrs121918407GRCh37Chr 2, 157435621: 157435621
7SLC2A2NM_000340.1(SLC2A2): c.589G> A (p.Val197Ile)single nucleotide variantPathogenicrs121909741GRCh37Chr 3, 170724960: 170724960
8GCGRNM_000160.4(GCGR): c.118G> A (p.Gly40Ser)single nucleotide variantPathogenicrs1801483GRCh37Chr 17, 79767715: 79767715
9IRS1IRS1, 3-BP DEL, GLY723deletionPathogenic
10IRS1NM_005544.2(IRS1): c.1823C> G (p.Thr608Arg)single nucleotide variantPathogenicrs104893642GRCh37Chr 2, 227661632: 227661632
11MAPK8IP1NM_005456.3(MAPK8IP1): c.176G> A (p.Ser59Asn)single nucleotide variantPathogenicrs119489103GRCh37Chr 11, 45919710: 45919710
12NEUROD1NM_002500.4(NEUROD1): c.332G> T (p.Arg111Leu)single nucleotide variantPathogenicrs104893649GRCh37Chr 2, 182543256: 182543256
13PDX1NM_000209.3(PDX1): c.492G> T (p.Glu164Asp)single nucleotide variantPathogenic, risk factorrs80356661GRCh37Chr 13, 28498478: 28498478
14ABCC8NM_001287174.1(ABCC8): c.4138C> T (p.Arg1380Cys)single nucleotide variantPathogenicrs137852673GRCh37Chr 11, 17417462: 17417462
15ABCC8NM_001287174.1(ABCC8): c.1744C> G (p.Leu582Val)single nucleotide variantPathogenicrs137852674GRCh37Chr 11, 17452434: 17452434
16HNF4ANM_000457.4(HNF4A): c.1204G> A (p.Val402Ile)single nucleotide variantPathogenicrs137853337GRCh37Chr 20, 43057049: 43057049

Expression for genes affiliated with Type 2 Diabetes Mellitus

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Type 2 Diabetes Mellitus

Search GEO for disease gene expression data for Type 2 Diabetes Mellitus.

Pathways for genes affiliated with Type 2 Diabetes Mellitus

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Sources:
50PathCards, 55Reactome, 30KEGG, 60Thomson Reuters, 53QIAGEN, 61Tocris Bioscience, 38NCBI BioSystems Database, 54R&D Systems, 51PharmGKB, 5Cell Signaling Technology
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Pathways related to Type 2 Diabetes Mellitus according to GeneCards/GeneDecks:

(show all 31)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
10.4TCF7L2, LEP
2
Show member pathways
Signal transduction PTEN pathway60
10.4IRS1, TCF7L2, AKT2
3
Show member pathways
10.4AKT2, INSR, PPP1R3A
4
Show member pathways
Insulin Pathway38
10.4AKT2, IRS1, INSR
5
Show member pathways
10.4INSR, IRS1, AKT2
6
Show member pathways
Prolactin Signaling Pathway38
Development Prolactin receptor signaling60
Leptin signaling pathway38
10.4AKT2, IRS1, LEP
710.4SLC2A4, IRS1, LEP
810.4INSR, LEP, IRS1
9
Show member pathways
10.4TCF7L2, TCF4, AKT2, HNF4A
10
Show member pathways
10.4PAX4, AKT2, HNF1B, HNF4A
11
Show member pathways
DNA damage response (only ATM dependent)38
Wnt Signaling Pathway and Pluripotency38
10.4AKT2, TCF7L2, IRS1, INSR
1210.4SLC2A4, AKT2, INSR, PPP1R3A
13
Show member pathways
10.4INSR, IRS1, AKT2, SLC2A4
14
Show member pathways
PLK2 and PLK4 events38
Polo-like kinase signaling events in the cell cycle38
10.4INSR, IRS1, AKT2, SLC2A4
15
Show member pathways
10.4PPP1R3A, INSR, IRS1, SLC2A4
1610.4LEP, IRS1, AKT2, SLC2A4
17
Show member pathways
10.4AKT2, IRS1, LEP, INSR
18
Show member pathways
10.3TCF7L2, TCF4, AKT2, HNF4A, SLC2A4
1910.3KCNJ11, LEP, IRS1, AKT2, SLC2A4
20
Show member pathways
Transcription Receptor mediated HIF regulation60
Development CNTF receptor signaling60
Class IB PI3K non-lipid kinase events38
ErbB2/ErbB3 signaling events38
Development Growth hormone signaling via PI3K AKT and MAPK cascades60
Translation Regulation activity of EIF260
Regulation of lipid metabolism Insulin signaling generic cascades60
Transcription PPAR Pathway60
Cell adhesion PLAU signaling60
Translation Regulation activity of EIF4F60
10.3SLC2A4, AKT2, IRS1, INSR, PPP1R3A
21
Show member pathways
10.3PPARGC1B, GPD2, LEP, SLC2A4
22
Show member pathways
10.3INSR, IRS1, AKT2, MAPK8IP1, SLC2A4
23
Show member pathways
10.3INSR, LEP, IRS1, AKT2, SLC2A4
24
Show member pathways
IL-9 Signaling Pathway38
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway38
Immune response IL 9 signaling pathway60
10.3INSR, LEP, IRS1, AKT2, SLC2A4
2510.3PPP1R3A, INSR, IRS1, AKT2, ENPP1, SLC2A4
26
Show member pathways
10.3SLC2A4, HNF4A, HNF1B, IRS1, INSR, KCNJ11
2710.3PPARGC1B, INSR, LEP, AKT2, HNF4A, SLC2A4
28
Show member pathways
10.3LEP, PAX4, TCF4, AKT2, HNF1B, HNF4A
29
Show member pathways
10.3INSR, IRS1, TCF7L2, TCF4, AKT2, MAPK8IP1
3010.3PEA15, INSR, IRS1, AKT2, HNF4A, ENPP1
31
Show member pathways
10.3PPP1R3A, INSR, IRS1, TCF7L2, TCF4, AKT2

Compounds for genes affiliated with Type 2 Diabetes Mellitus

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Sources:
51PharmGKB, 45Novoseek, 11DrugBank, 29IUPHAR, 61Tocris Bioscience, 24HMDB
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Compounds related to Type 2 Diabetes Mellitus according to GeneCards/GeneDecks:

(show top 50)    (show all 74)
idCompoundScoreTop Affiliating Genes
1repaglinide51 45 1112.8KCNJ11, PAX4, TCF7L2
2vanadium4510.8SLC2A4, INSR, IRS1
3gliclazide45 51 1112.8INSR, SLC2A4, KCNJ11
4glimepiride45 51 1112.8KCNJ11, SLC2A4, INSR
5sulfonamides, urea derivatives5110.8TCF7L2, KCNJ11
6sulfonylurea4510.8SLC2A4, KCNJ11, IRS1
7glibenclamide45 29 51 6113.8SLC2A4, KCNJ11, INSR, LEP
82-deoxyglucose45 1111.8PPP1R3A, INSR, SLC2A4, IRS1
9pioglitazone29 45 51 1113.7INSR, LEP, SHBG, SLC2A4, IRS1
10rosiglitazone29 45 51 24 1114.7SHBG, INSR, IRS1, SLC2A4, LEP
11c-peptide4510.7HNF4A, IRS1, SHBG, LEP, KCNJ11, INSR
12thiazolidinedione4510.7SLC2A4, LEP, IRS1
13rapamycin4510.7AKT2, ENPP1, INSR, LEP, IRS1, SLC2A4
14ly2940024510.7INSR, LEP, IRS1, TCF7L2, AKT2, SLC2A4
15palmitate4510.7IRS1, HNF4A, INSR, SLC2A4
16metformin45 51 1112.7KCNJ11, INSR, LEP, SHBG, IRS1, ENPP1
17troglitazone45 29 61 1113.7SLC2A4, IRS1, LEP, INSR
18aicar45 24 1112.7SLC2A4, LEP, INSR
19tamoxifen45 51 29 1113.7SLC2A4, AKT2, IRS1, SHBG, LEP
20phenylarsine oxide4510.7IRS1, INSR, SLC2A4
21fatty acid4510.7ENPP1, HNF4A, SLC2A4, LEP, PPARGC1B, IRS1
22glycogen45 2411.7PPP1R3A, INSR, IRS1, HNF4A, ENPP1, SLC2A4
23pd 98,0594510.7LEP, IRS1, SLC2A4, HNF4A, INSR
24glycerol45 24 1112.7IDE, IRS1, HNF4A, INSR, LEP, SHBG
25wortmannin4510.7INSR, SLC2A4, AKT2, IRS1, LEP
26dexamethasone45 51 29 1113.7SLC2A4, ENPP1, HNF4A, IRS1, INSR, SHBG
27threonine4510.7MAPK8IP1, INSR, AKT2, SLC2A4, ENPP1, IRS1
28glutamine4510.7HNF4A, ENPP1, INSR, KCNJ11, IDE
29valine4510.7INSR, IDE, SLC2A4, KCNJ11
30streptozotocin4510.7INSR, IRS1, SLC2A4
31testosterone45 61 24 1113.7SLC2A4, HNF4A, LEP, INSR, TCF7L2, IRS1
32arginine4510.7HNF4A, HNF1B, SHBG, KCNJ11, IRS1, INSR
33glucosamine45 24 1112.6INSR, IRS1, SLC2A4
34glycerol 3-phosphate45 2411.6SLC2A4, LEP, GPD2
35serine4510.6SLC2A4, ENPP1, INSR, IDE, LEP, HNF4A
36phosphatidylinositol4510.6TCF7L2, SLC2A4, IDE, INSR, PEA15, ENPP1
37phosphoenolpyruvate45 1111.6IRS1, SLC2A4, HNF4A
38lipid4510.6ENPP1, PPP1R3A, INSR, IDE, LEP, TCF7L2
39glutamate4510.6HNF4A, INSR, IDE, LEP, IRS1, KCNJ11
40alanine4510.6HNF4A, IRS1, SHBG, IDE, INSR, SLC2A4
413-o-methylglucose4510.5SLC2A4, INSR
42epinephrine45 24 1112.5SHBG, LEP, INSR, PPP1R3A
43estrogen4510.5HNF4A, INSR, LEP, SHBG, IRS1, AKT2
44phosphotyrosine4510.5SLC2A4, MAPK8IP1, IRS1, INSR
45grp-14510.4INSR, SLC2A4
46glucose4510.4MAPK8IP1, PPP1R3A, PEA15, GPD2, INSR, IDE
47h2o24510.4IRS1, SLC2A4, LEP, INSR, GPD2
48sb 20358045 6111.4INSR, IRS1, AKT2, SLC2A4
49vanadyl sulfate4510.3IRS1, INSR
50losartan45 51 29 1113.1SLC2A4, LEP, IRS1

GO Terms for genes affiliated with Type 2 Diabetes Mellitus

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Sources:
16Gene Ontology
See all sources

Cellular components related to Type 2 Diabetes Mellitus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1insulin receptor complexGO:00589910.4IRS1, INSR

Biological processes related to Type 2 Diabetes Mellitus according to GeneCards/GeneDecks:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of glycogen biosynthetic processGO:04572510.7AKT2, IRS1, INSR
2positive regulation of glucose importGO:04632610.7INSR, IRS1, AKT2
3positive regulation of glucose import in response to insulin stimulusGO:200127510.7AKT2, IRS1
4endocrine pancreas developmentGO:03101810.7PAX4, HNF1B, HNF4A
5positive regulation of developmental growthGO:04863910.7LEP, INSR
6cellular response to insulin stimulusGO:03286910.7SLC2A4, ENPP1, AKT2, IRS1, INSR
7positive regulation of glucose metabolic processGO:01090710.7AKT2, IRS1
8glucose homeostasisGO:04259310.7INSR, IRS1, TCF7L2, HNF4A, SLC2A4
9response to glucoseGO:00974910.7TCF7L2, HNF1B, HNF4A
10insulin receptor signaling pathwayGO:00828610.7AKT2, IRS1, IDE, INSR
11positive regulation of fatty acid beta-oxidationGO:03200010.6AKT2, IRS1
12negative regulation of glucose importGO:04632510.6ENPP1, PEA15
13regulation of insulin secretionGO:05079610.6KCNJ11, LEP, HNF4A
14positive regulation of insulin receptor signaling pathwayGO:04662810.6IRS1, LEP
15glucose metabolic processGO:00600610.5AKT2, LEP, KCNJ11
16positive regulation of transcription from RNA polymerase II promoterGO:04594410.4PPARGC1B, TCF7L2, TCF4, HNF1B, HNF4A
17negative regulation of insulin secretionGO:04667610.4IRS1, KCNJ11
18carbohydrate transportGO:00864310.4PEA15, AKT2
19embryonic digestive tract morphogenesisGO:04855710.3HNF1B, TCF7L2
20negative regulation of insulin receptor signaling pathwayGO:04662710.1ENPP1, IRS1

Molecular functions related to Type 2 Diabetes Mellitus according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1insulin bindingGO:04355910.6IDE, INSR
2insulin-like growth factor receptor bindingGO:00515910.5IRS1, INSR
3phosphatidylinositol 3-kinase bindingGO:04354810.5INSR, IRS1
4insulin receptor bindingGO:00515810.4ENPP1, IRS1
5transcription regulatory region DNA bindingGO:04421210.4HNF4A, HNF1B, TCF7L2
6protein bindingGO:00551510.3PEA15, INSR, IDE, IRS1, TCF7L2, TCF4
7sequence-specific DNA binding transcription factor activityGO:00370010.3PAX4, TCF7L2, TCF4, HNF1B, HNF4A
8sequence-specific DNA bindingGO:04356510.1HNF4A, HNF1B, TCF7L2, PAX4

Products for genes affiliated with Type 2 Diabetes Mellitus

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Type 2 Diabetes Mellitus

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet