MCID: TYP014
MIFTS: 23

Type 2a Von Willebrand Disease malady

Summaries for Type 2a Von Willebrand Disease

About this section
Sources:
32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MalaCards: Type 2a Von Willebrand Disease, also known as von willebrand disease, type 2a, is related to myocardial infarction and leukemia. An important gene associated with Type 2a Von Willebrand Disease is VWF (von Willebrand factor), and among its related pathways are Platelet degranulation and Complement and coagulation cascades. The compounds warfarin and recombinate have been mentioned in the context of this disorder.

Aliases & Classifications for Type 2a Von Willebrand Disease

About this section
Sources:
20GeneTests, 22GTR, 60UMLS
See all sources

Aliases & Descriptions:

type 2a von willebrand disease 20 22
von willebrand disease, type 2a 60


Related Diseases for Type 2a Von Willebrand Disease

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Type 2a Von Willebrand Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 46)
idRelated DiseaseScoreTop Affiliating Genes
1myocardial infarction30.4VWF, F8
2leukemia10.3
3uterine disease10.3
4von willebrand disease, types 2a, 2b, 2m, and 2n10.3
5factor xi deficiency10.0F8
6hemophilia b10.0F8
7disseminated intravascular coagulation10.0F8
8hemangioma10.0F8
9hypercholesterolemia10.0F8
10factor xii deficiency10.0VWF
11acute myocardial infarction10.0VWF
12coronary heart disease10.0VWF
13glanzmann's thrombasthenia10.0VWF
14hellp syndrome10.0VWF
15thrombocytosis10.0VWF
16hemolytic-uremic syndrome10.0VWF
17angiosarcoma10.0VWF
18uremia10.0VWF
19connective tissue disease10.0VWF
20sickle cell disease10.0VWF
21hemarthrosis10.0VWF, F8
22intracranial thrombosis10.0VWF, F8
23hemorrhagic disease10.0F8, VWF
24blood platelet disease10.0VWF, F8
25von willebrand's disease10.0VWF, F8
26factor viii deficiency10.0F8, VWF
27afibrinogenemia10.0VWF, F8
28thrombotic thrombocytopenic purpura, acquired10.0VWF, F8
29bernard-soulier syndrome10.0F8, VWF
30venous thrombosis10.0VWF, F8
31thrombophilia10.0VWF, F8
32antiphospholipid syndrome10.0VWF, F8
33hyperhomocysteinemia10.0F8, VWF
34congenital heart defect10.0VWF, F8
35retinal disease10.0VWF, F8
36hypersensitivity reaction type ii disease10.0F8, VWF
37factor v leiden thrombophilia10.0VWF, F8
38atherosclerosis10.0VWF, ADAMTS1
39pre-eclampsia10.0VWF, F8
40thromboembolism10.0VWF, F8
41thrombocytopenia10.0F8, VWF
42type 2 diabetes mellitus10.0F8, VWF
43prion disease10.0VWF, F8
44systemic lupus erythematosus10.0F8, VWF
45cadasil10.0F8, VWF
46hypothyroidism10.0VWF, F8

Graphical network of the top 20 diseases related to Type 2a Von Willebrand Disease:



Diseases related to type 2a von willebrand disease

Clinical Features for Type 2a Von Willebrand Disease

About this section

Drugs & Therapeutics for Type 2a Von Willebrand Disease

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Type 2a Von Willebrand Disease

Drug clinical trials:

Search ClinicalTrials for Type 2a Von Willebrand Disease

Search NIH Clinical Center for Type 2a Von Willebrand Disease

Search CenterWatch for Type 2a Von Willebrand Disease

Genetic Tests for Type 2a Von Willebrand Disease

About this section
Sources:
20GeneTests, 22GTR
See all sources

Genetic tests related to Type 2a Von Willebrand Disease:

id Genetic test Affiliating Genes
1 Type 2a Von Willebrand Disease20
2 Von Willebrand Disease, Type 2a22

Anatomical Context for Type 2a Von Willebrand Disease

About this section

Animal Models for Type 2a Von Willebrand Disease or affiliated genes

About this section

Publications for Type 2a Von Willebrand Disease

About this section

Genetic Variations for Type 2a Von Willebrand Disease

About this section

Expression for genes affiliated with Type 2a Von Willebrand Disease

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Type 2a Von Willebrand Disease

Search GEO for disease gene expression data for Type 2a Von Willebrand Disease.

Pathways for genes affiliated with Type 2a Von Willebrand Disease

About this section
Sources:
53Reactome, 29KEGG, 37NCBI BioSystems Database, 52R&D Systems
See all sources

Pathways related to Type 2a Von Willebrand Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.0VWF, F8
2
Hide members
9.0VWF, F8
3
Hide members
9.0VWF, F8

Compounds for genes affiliated with Type 2a Von Willebrand Disease

About this section
Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 59Tocris Bioscience, 28IUPHAR, 2BitterDB
See all sources

Compounds related to Type 2a Von Willebrand Disease according to GeneCards/GeneDecks:

(show all 28)
idCompoundScoreTop Affiliating Genes
1warfarin44 49 11 2413.2VWF
2recombinate449.4VWF, F8
3kogenate449.4VWF, F8
4tributylphosphate449.4VWF, F8
5rfviii449.4F8, VWF
6hydroxyethyl starch449.4VWF, F8
7tranexamic acid44 1110.4VWF, F8
8ristocetin449.4VWF, F8
9desmopressin44 59 28 1112.4VWF, F8
10hirudin449.4VWF, F8
11ivig449.4F8, VWF
12rituximab44 49 1111.3VWF, F8
13tgf beta1449.3ADAMTS1, F8
14acetaminophen44 2 49 11 2413.3VWF, F8
15thromboxane a244 2410.3F8, VWF
16latex449.3VWF, F8
17homocysteine44 2410.3VWF, F8
18prednisolone44 28 1111.3VWF, F8
19citrate449.3F8, VWF
20agarose449.2VWF, F8
21cyclophosphamide44 49 1111.2F8, VWF
22prostacyclin449.1VWF, F8
23phosphatidylserine44 28 1111.1VWF, F8
24aspirin44 49 28 2412.0VWF, F8
25methionine449.0VWF, F8
26heparin44 28 11 2411.9F8, VWF, ADAMTS1
27epinephrine44 11 2410.7VWF, F8
28serine448.4F8, VWF, ADAMTS1

GO Terms for genes affiliated with Type 2a Von Willebrand Disease

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Type 2a Von Willebrand Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.0VWF, F8

Biological processes related to Type 2a Von Willebrand Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet activationGO:0301689.0VWF, F8
2blood coagulation, intrinsic pathwayGO:0075978.9VWF, F8
3platelet degranulationGO:0025768.7VWF, F8

Products for genes affiliated with Type 2a Von Willebrand Disease

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Type 2a Von Willebrand Disease

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet