MCID: TYP016
MIFTS: 23

Type 2m Von Willebrand Disease malady

Summaries for Type 2m Von Willebrand Disease

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32MalaCards
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MalaCards: Type 2m Von Willebrand Disease, also known as von willebrand disease type 2m, is related to collagen disease and autosomal dominant disease. An important gene associated with Type 2m Von Willebrand Disease is VWF (von Willebrand factor), and among its related pathways are Platelet degranulation and Complement and coagulation cascades. The compounds warfarin and recombinate have been mentioned in the context of this disorder.

Aliases & Classifications for Type 2m Von Willebrand Disease

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20GeneTests, 22GTR, 60UMLS
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Aliases & Descriptions:

type 2m von willebrand disease 20 22
von willebrand disease type 2m 60


Related Diseases for Type 2m Von Willebrand Disease

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17GeneCards, 18GeneDecks
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Diseases related to Type 2m Von Willebrand Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 46)
idRelated DiseaseScoreTop Affiliating Genes
1collagen disease10.6
2autosomal dominant disease10.4
3von willebrand disease, types 2a, 2b, 2m, and 2n10.4
4factor xi deficiency10.0F8
5hemophilia b10.0F8
6disseminated intravascular coagulation10.0F8
7hemangioma10.0F8
8hypercholesterolemia10.0F8
9factor xii deficiency10.0VWF
10glanzmann's thrombasthenia10.0VWF
11hellp syndrome10.0VWF
12thrombocytosis10.0VWF
13hemolytic-uremic syndrome10.0VWF
14angiosarcoma10.0VWF
15uremia10.0VWF
16connective tissue disease10.0VWF
17sickle cell disease10.0VWF
18coronary heart disease10.0VWF
19hemarthrosis10.0F8, VWF
20intracranial thrombosis10.0VWF, F8
21hemorrhagic disease10.0F8, VWF
22blood platelet disease10.0VWF, F8
23acute myocardial infarction10.0VWF
24afibrinogenemia10.0F8, VWF
25factor viii deficiency10.0F8, VWF
26thrombotic thrombocytopenic purpura, acquired10.0VWF, F8
27bernard-soulier syndrome10.0F8, VWF
28venous thrombosis10.0VWF, F8
29von willebrand's disease10.0F8, VWF
30thrombophilia10.0VWF, F8
31antiphospholipid syndrome10.0VWF, F8
32hyperhomocysteinemia10.0VWF, F8
33congenital heart defect10.0VWF, F8
34retinal disease10.0F8, VWF
35hypersensitivity reaction type ii disease10.0VWF, F8
36factor v leiden thrombophilia10.0VWF, F8
37pre-eclampsia10.0VWF, F8
38thromboembolism10.0F8, VWF
39thrombocytopenia10.0VWF, F8
40type 2 diabetes mellitus10.0F8, VWF
41prion disease10.0VWF, F8
42cadasil10.0VWF, F8
43hypothyroidism10.0F8, VWF
44systemic lupus erythematosus10.0VWF, F8
45primary hyperoxaluria10.0F8, VWF
46vascular disease10.0VWF, F8

Graphical network of the top 20 diseases related to Type 2m Von Willebrand Disease:



Diseases related to type 2m von willebrand disease

Clinical Features for Type 2m Von Willebrand Disease

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Drugs & Therapeutics for Type 2m Von Willebrand Disease

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Type 2m Von Willebrand Disease

Drug clinical trials:

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Search NIH Clinical Center for Type 2m Von Willebrand Disease

Search CenterWatch for Type 2m Von Willebrand Disease

Genetic Tests for Type 2m Von Willebrand Disease

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20GeneTests, 22GTR
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Genetic tests related to Type 2m Von Willebrand Disease:

id Genetic test Affiliating Genes
1 Type 2m Von Willebrand Disease20
2 Von Willebrand Disease Type 2m22

Anatomical Context for Type 2m Von Willebrand Disease

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Animal Models for Type 2m Von Willebrand Disease or affiliated genes

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Publications for Type 2m Von Willebrand Disease

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Genetic Variations for Type 2m Von Willebrand Disease

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Expression for genes affiliated with Type 2m Von Willebrand Disease

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Type 2m Von Willebrand Disease

Search GEO for disease gene expression data for Type 2m Von Willebrand Disease.

Pathways for genes affiliated with Type 2m Von Willebrand Disease

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53Reactome, 29KEGG, 37NCBI BioSystems Database, 52R&D Systems
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Pathways related to Type 2m Von Willebrand Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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9.1VWF, F8
2
Hide members
9.1VWF, F8
3
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9.1VWF, F8

Compounds for genes affiliated with Type 2m Von Willebrand Disease

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 59Tocris Bioscience, 28IUPHAR, 2BitterDB
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Compounds related to Type 2m Von Willebrand Disease according to GeneCards/GeneDecks:

(show all 34)
idCompoundScoreTop Affiliating Genes
1warfarin44 49 11 2413.0VWF
2recombinate449.5VWF, F8
3kogenate449.5VWF, F8
4tributylphosphate449.5VWF, F8
5rfviii449.5VWF, F8
6hydroxyethyl starch449.5F8, VWF
7tranexamic acid44 1110.5VWF, F8
8ristocetin449.5VWF, F8
9desmopressin44 59 28 1112.5VWF, F8
10hirudin449.5F8, VWF
11ivig449.5VWF, F8
12rituximab44 49 1111.5VWF, F8
13acetaminophen44 2 49 11 2413.5VWF, F8
14thromboxane a244 2410.5F8, VWF
15latex449.5VWF, F8
16homocysteine44 2410.5VWF, F8
17prednisolone44 28 1111.5VWF, F8
18citrate449.4F8, VWF
19agarose449.4VWF, F8
20cyclophosphamide44 49 1111.4VWF, F8
21prostacyclin449.4VWF, F8
22phosphatidylserine44 28 1111.4F8, VWF
23aspirin44 49 28 2412.4VWF, F8
24epinephrine44 11 2411.4VWF, F8
25methionine449.4VWF, F8
26fibrinogen449.3F8, VWF
27norepinephrine44 11 2411.3VWF, F8
28phospholipid449.3VWF, F8
29cyclosporin a44 28 5911.2VWF, F8
30glutamine449.2F8, VWF
31lactate449.1VWF, F8
32heparin44 28 11 2412.1VWF, F8
33creatinine449.0VWF, F8
34aspartate448.8VWF, F8

GO Terms for genes affiliated with Type 2m Von Willebrand Disease

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16Gene Ontology
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Cellular components related to Type 2m Von Willebrand Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.1VWF, F8

Biological processes related to Type 2m Von Willebrand Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1blood coagulation, intrinsic pathwayGO:0075979.2VWF, F8
2platelet degranulationGO:0025769.1VWF, F8
3blood coagulationGO:0075969.1VWF, F8
4platelet activationGO:0301689.0F8, VWF
5cell adhesionGO:0071558.8VWF, F8

Products for genes affiliated with Type 2m Von Willebrand Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Type 2m Von Willebrand Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet