MCID: TYP017
MIFTS: 23

Type 2n Von Willebrand Disease malady

Summaries for Type 2n Von Willebrand Disease

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MalaCards: Type 2n Von Willebrand Disease, also known as von willebrand disease, type 2n, is related to hemarthrosis and hemophilia. An important gene associated with Type 2n Von Willebrand Disease is F8 (coagulation factor VIII, procoagulant component), and among its related pathways are Platelet degranulation and Complement and coagulation cascades. The compounds warfarin and recombinate have been mentioned in the context of this disorder.

Aliases & Classifications for Type 2n Von Willebrand Disease

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20GeneTests, 22GTR, 60UMLS
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Aliases & Descriptions:

type 2n von willebrand disease 20 22
von willebrand disease, type 2n 60


Related Diseases for Type 2n Von Willebrand Disease

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17GeneCards, 18GeneDecks
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Diseases related to Type 2n Von Willebrand Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 45)
idRelated DiseaseScoreTop Affiliating Genes
1hemarthrosis30.5F8, VWF
2hemophilia10.4
3von willebrand disease, types 2a, 2b, 2m, and 2n10.4
4factor xii deficiency10.0VWF
5glanzmann's thrombasthenia10.0VWF
6hellp syndrome10.0VWF
7thrombocytosis10.0VWF
8hemolytic-uremic syndrome10.0VWF
9angiosarcoma10.0VWF
10uremia10.0VWF
11connective tissue disease10.0VWF
12sickle cell disease10.0VWF
13factor xi deficiency10.0F8
14hemophilia b10.0F8
15disseminated intravascular coagulation10.0F8
16hemangioma10.0F8
17coronary heart disease10.0VWF
18hypercholesterolemia10.0F8
19acute myocardial infarction10.0VWF
20intracranial thrombosis10.0VWF, F8
21hemorrhagic disease10.0F8, VWF
22blood platelet disease10.0VWF, F8
23afibrinogenemia10.0F8, VWF
24factor viii deficiency10.0F8, VWF
25thrombotic thrombocytopenic purpura, acquired10.0VWF, F8
26bernard-soulier syndrome10.0F8, VWF
27venous thrombosis10.0VWF, F8
28von willebrand's disease10.0F8, VWF
29thrombophilia10.0VWF, F8
30antiphospholipid syndrome10.0VWF, F8
31hyperhomocysteinemia10.0VWF, F8
32congenital heart defect10.0VWF, F8
33retinal disease10.0F8, VWF
34hypersensitivity reaction type ii disease10.0VWF, F8
35factor v leiden thrombophilia10.0VWF, F8
36pre-eclampsia10.0VWF, F8
37thromboembolism10.0F8, VWF
38thrombocytopenia10.0VWF, F8
39type 2 diabetes mellitus10.0F8, VWF
40prion disease10.0VWF, F8
41cadasil10.0VWF, F8
42hypothyroidism10.0F8, VWF
43systemic lupus erythematosus10.0VWF, F8
44primary hyperoxaluria10.0F8, VWF
45vascular disease10.0VWF, F8

Graphical network of the top 20 diseases related to Type 2n Von Willebrand Disease:



Diseases related to type 2n von willebrand disease

Clinical Features for Type 2n Von Willebrand Disease

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Drugs & Therapeutics for Type 2n Von Willebrand Disease

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Type 2n Von Willebrand Disease

Search CenterWatch for Type 2n Von Willebrand Disease

Genetic Tests for Type 2n Von Willebrand Disease

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20GeneTests, 22GTR
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Genetic tests related to Type 2n Von Willebrand Disease:

id Genetic test Affiliating Genes
1 Type 2n Von Willebrand Disease20
2 Von Willebrand Disease Type 2n22

Anatomical Context for Type 2n Von Willebrand Disease

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Animal Models for Type 2n Von Willebrand Disease or affiliated genes

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Publications for Type 2n Von Willebrand Disease

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Genetic Variations for Type 2n Von Willebrand Disease

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Expression for genes affiliated with Type 2n Von Willebrand Disease

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Type 2n Von Willebrand Disease

Search GEO for disease gene expression data for Type 2n Von Willebrand Disease.

Pathways for genes affiliated with Type 2n Von Willebrand Disease

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53Reactome, 29KEGG, 37NCBI BioSystems Database, 52R&D Systems
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Pathways related to Type 2n Von Willebrand Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.1VWF, F8
2
Hide members
9.1VWF, F8
3
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9.1VWF, F8

Compounds for genes affiliated with Type 2n Von Willebrand Disease

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 59Tocris Bioscience, 28IUPHAR, 2BitterDB
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Compounds related to Type 2n Von Willebrand Disease according to GeneCards/GeneDecks:

(show all 34)
idCompoundScoreTop Affiliating Genes
1warfarin44 49 11 2413.3VWF
2recombinate449.5VWF, F8
3kogenate449.5VWF, F8
4tributylphosphate449.5VWF, F8
5rfviii449.5VWF, F8
6hydroxyethyl starch449.5F8, VWF
7tranexamic acid44 1110.5VWF, F8
8ristocetin449.5VWF, F8
9desmopressin44 59 28 1112.5VWF, F8
10hirudin449.5F8, VWF
11ivig449.5VWF, F8
12rituximab44 49 1111.5VWF, F8
13acetaminophen44 2 49 11 2413.5VWF, F8
14thromboxane a244 2410.5F8, VWF
15latex449.5VWF, F8
16homocysteine44 2410.5VWF, F8
17prednisolone44 28 1111.5VWF, F8
18citrate449.4F8, VWF
19agarose449.4VWF, F8
20cyclophosphamide44 49 1111.4VWF, F8
21prostacyclin449.4VWF, F8
22phosphatidylserine44 28 1111.4F8, VWF
23aspirin44 49 28 2412.4VWF, F8
24epinephrine44 11 2411.4VWF, F8
25methionine449.4VWF, F8
26fibrinogen449.3F8, VWF
27norepinephrine44 11 2411.3VWF, F8
28phospholipid449.3VWF, F8
29cyclosporin a44 28 5911.2VWF, F8
30glutamine449.2F8, VWF
31lactate449.1VWF, F8
32heparin44 28 11 2412.1VWF, F8
33creatinine449.0VWF, F8
34aspartate448.8VWF, F8

GO Terms for genes affiliated with Type 2n Von Willebrand Disease

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16Gene Ontology
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Cellular components related to Type 2n Von Willebrand Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.1VWF, F8

Biological processes related to Type 2n Von Willebrand Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1blood coagulation, intrinsic pathwayGO:0075979.2VWF, F8
2platelet degranulationGO:0025769.1VWF, F8
3blood coagulationGO:0075969.1VWF, F8
4platelet activationGO:0301689.0F8, VWF
5cell adhesionGO:0071558.8VWF, F8

Products for genes affiliated with Type 2n Von Willebrand Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Type 2n Von Willebrand Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet