MCID: TYP018
MIFTS: 23

Type 3 Von Willebrand Disease malady

Summaries for Type 3 Von Willebrand Disease

About this section
Sources:
32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MalaCards: Type 3 Von Willebrand Disease, also known as von willebrand disease, type 3, is related to hemorrhagic disease and von willibrand disease, type 3. An important gene associated with Type 3 Von Willebrand Disease is F8 (coagulation factor VIII, procoagulant component), and among its related pathways are Platelet activation, signaling and aggregation and Platelet degranulation . The compounds warfarin and propranolol have been mentioned in the context of this disorder.

Aliases & Classifications for Type 3 Von Willebrand Disease

About this section
Sources:
20GeneTests, 60UMLS
See all sources

Aliases & Descriptions:

type 3 von willebrand disease 20
von willebrand disease, type 3 60


Related Diseases for Type 3 Von Willebrand Disease

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Type 3 Von Willebrand Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 56)
idRelated DiseaseScoreTop Affiliating Genes
1hemorrhagic disease30.3F8, VWF
2von willibrand disease, type 310.5
3type 1 von willebrand disease10.3
4central retinal vein occlusion10.0PLAT
5hypercholesterolemia10.0F8
6factor xi deficiency10.0F8
7thrombophlebitis10.0F8
8hemophilia b10.0F8
9portal vein thrombosis10.0F8
10cystic fibrosis10.0F8
11primary hyperoxaluria10.0F8
12hellp syndrome10.0VWF
13hemolytic-uremic syndrome10.0VWF
14uremia10.0VWF
15sickle cell disease10.0VWF
16factor xii deficiency10.0VWF
17hypertension10.0PLAT
18intermittent claudication10.0VWF
19glanzmann's thrombasthenia10.0VWF
20thrombocytosis10.0VWF
21hemangioma10.0F8
22angiosarcoma10.0VWF
23disseminated intravascular coagulation10.0F8, PLAT
24peripheral vascular disease10.0VWF, PLAT
25connective tissue disease10.0VWF
26coronary thrombosis10.0VWF, PLAT
27acute myocardial infarction10.0VWF, PLAT
28hypersensitivity reaction type ii disease10.0F8, VWF
29hemarthrosis10.0F8, VWF
30intracranial thrombosis10.0F8, VWF
31coronary heart disease10.0PLAT, VWF
32thrombocytopenia10.0VWF, F8
33blood platelet disease10.0VWF, F8
34von willebrand's disease10.0F8, VWF
35afibrinogenemia10.0F8, VWF
36factor viii deficiency10.0F8, VWF
37thrombotic thrombocytopenic purpura, acquired10.0VWF, F8
38bernard-soulier syndrome10.0F8, VWF
39atherosclerosis10.0VWF, PLAT
40congenital heart defect10.0F8, VWF
41retinal disease10.0VWF, F8
42stroke, ischemic10.0VWF, PLAT
43coronary artery disease10.0PLAT, VWF
44venous thrombosis10.0F8, VWF, PLAT
45thrombophilia10.0F8, VWF, PLAT
46antiphospholipid syndrome10.0PLAT, VWF, F8
47hyperhomocysteinemia10.0F8, VWF, PLAT
48factor v leiden thrombophilia10.0F8, VWF, PLAT
49pre-eclampsia10.0PLAT, VWF, F8
50thromboembolism10.0F8, VWF, PLAT

Graphical network of the top 20 diseases related to Type 3 Von Willebrand Disease:



Diseases related to type 3 von willebrand disease

Clinical Features for Type 3 Von Willebrand Disease

About this section

Drugs & Therapeutics for Type 3 Von Willebrand Disease

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Type 3 Von Willebrand Disease

Drug clinical trials:

Search ClinicalTrials for Type 3 Von Willebrand Disease

Search NIH Clinical Center for Type 3 Von Willebrand Disease

Search CenterWatch for Type 3 Von Willebrand Disease

Genetic Tests for Type 3 Von Willebrand Disease

About this section
Sources:
20GeneTests
See all sources

Genetic tests related to Type 3 Von Willebrand Disease:

id Genetic test Affiliating Genes
1 Type 3 Von Willebrand Disease20

Anatomical Context for Type 3 Von Willebrand Disease

About this section

Animal Models for Type 3 Von Willebrand Disease or affiliated genes

About this section

Publications for Type 3 Von Willebrand Disease

About this section

Genetic Variations for Type 3 Von Willebrand Disease

About this section

Expression for genes affiliated with Type 3 Von Willebrand Disease

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Type 3 Von Willebrand Disease

Search GEO for disease gene expression data for Type 3 Von Willebrand Disease.

Pathways for genes affiliated with Type 3 Von Willebrand Disease

About this section
Sources:
53Reactome, 29KEGG, 37NCBI BioSystems Database, 52R&D Systems
See all sources

Pathways related to Type 3 Von Willebrand Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.1PLAT, VWF
2
Hide members
9.0VWF, F8
3
Hide members
8.5F8, VWF, PLAT
4
Hide members
8.5PLAT, VWF, F8

Compounds for genes affiliated with Type 3 Von Willebrand Disease

About this section
Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience
See all sources

Compounds related to Type 3 Von Willebrand Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 56)
idCompoundScoreTop Affiliating Genes
1warfarin44 49 11 2413.1VWF
2propranolol44 28 49 11 2413.6PLAT, F8
3integrilin449.6VWF, PLAT
4beraprost sodium449.6VWF, PLAT
5ppack449.5PLAT, VWF
6quinapril44 1110.5PLAT, VWF
7tirofiban44 1110.5PLAT, VWF
8perindopril44 49 1111.5PLAT, VWF
9ticlopidine44 1110.5VWF, PLAT
10abciximab44 1110.5PLAT, VWF
11ethidium bromide449.5VWF, PLAT
12clopidogrel49 44 11 2412.5PLAT, VWF
13recombinate449.5VWF, F8
14dermatan sulfate449.5VWF, PLAT
15tributylphosphate449.5F8, VWF
16kogenate449.5F8, VWF
17rfviii449.5VWF, F8
18thromboxane44 2410.5PLAT, VWF
19fluvastatin44 49 28 1112.4PLAT, VWF
20hydroxyethyl starch449.4F8, VWF
21kininogen449.4VWF, PLAT
22losartan44 49 28 1112.4PLAT, VWF
23pge1449.4PLAT, VWF
24ivig449.4VWF, F8
25aprotinin44 1110.4VWF, PLAT
26rituximab44 49 1111.3VWF, F8
27sodium nitroprusside449.3VWF, PLAT
28atorvastatin44 49 28 11 2413.2PLAT, VWF
29latex449.2VWF, F8
30thyroxine44 2410.1PLAT, VWF
31prednisolone44 28 1111.1VWF, F8
32citrate449.0F8, VWF
33tranexamic acid44 1110.0PLAT, VWF, F8
34ristocetin449.0PLAT, VWF, F8
35desmopressin44 59 28 1112.0F8, VWF, PLAT
36hirudin449.0PLAT, VWF, F8
37thromboxane a244 249.9F8, VWF, PLAT
38homocysteine44 249.9PLAT, VWF, F8
39agarose448.9VWF, F8
40prostacyclin448.9PLAT, VWF, F8
41aspirin44 49 28 2411.9PLAT, VWF, F8
42fibrinogen448.9F8, VWF, PLAT
43cyclosporin a44 28 5910.9PLAT, VWF, F8
44creatinine448.9F8, VWF, PLAT
45aspartate448.9PLAT, VWF, F8
46heparin44 28 11 2411.9PLAT, VWF, F8
47cholesterol44 28 11 2411.9PLAT, VWF, F8
48simvastatin44 49 59 28 11 2413.8PLAT, VWF
49adp44 28 2410.8F8, VWF, PLAT
50cysteine448.7PLAT, VWF, F8

GO Terms for genes affiliated with Type 3 Von Willebrand Disease

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Type 3 Von Willebrand Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310938.9VWF, F8
2extracellular matrixGO:0310128.8PLAT, VWF
3extracellular regionGO:0055768.5PLAT, VWF, F8

Biological processes related to Type 3 Von Willebrand Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1blood coagulation, intrinsic pathwayGO:0075979.0VWF, F8
2platelet activationGO:0301689.0VWF, F8
3platelet degranulationGO:0025768.7VWF, F8
4blood coagulationGO:0075968.4PLAT, VWF, F8

Products for genes affiliated with Type 3 Von Willebrand Disease

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Type 3 Von Willebrand Disease

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet