MCID: TYP018
MIFTS: 30

Type 3 Von Willebrand Disease malady

Genetic diseases (common) category
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Summaries for Type 3 Von Willebrand Disease

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MalaCards based summary: Type 3 Von Willebrand Disease, also known as von willebrand disease, type 3, is related to von willibrand disease, type 3 and central retinal vein occlusion. An important gene associated with Type 3 Von Willebrand Disease is VWF (von Willebrand factor), and among its related pathways are Response to elevated platelet cytosolic Ca2+ and Hemostasis. The compounds integrilin and beraprost sodium have been mentioned in the context of this disorder. Related mouse phenotype hematopoietic system.

Aliases & Classifications for Type 3 Von Willebrand Disease

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Type 3 Von Willebrand Disease, Aliases & Descriptions:

Name: Type 3 Von Willebrand Disease 20
 
Von Willebrand Disease, Type 3 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)


Related Diseases for Type 3 Von Willebrand Disease

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Diseases related to Type 3 Von Willebrand Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 42)
idRelated DiseaseScoreTop Affiliating Genes
1von willibrand disease, type 310.5
2central retinal vein occlusion10.4PLAT
3factor xii deficiency10.4VWF
4factor xi deficiency10.3F8
5thrombophlebitis10.3F8
6peripheral vascular disease10.1VWF, PLAT
7coronary thrombosis10.1VWF, PLAT
8stroke, ischemic10.1PLAT, VWF
9acute myocardial infarction10.0VWF, PLAT
10essential hypertension10.0PLAT, VWF
11hemarthrosis10.0VWF, F8
12intracranial thrombosis10.0F8, VWF
13disseminated intravascular coagulation10.0F8, PLAT
14hemorrhagic disease10.0F8, VWF
15blood platelet disease10.0VWF, F8
16von willebrand's disease10.0VWF, F8
17factor viii deficiency10.0F8, VWF
18afibrinogenemia10.0F8, VWF
19thrombotic thrombocytopenic purpura, acquired10.0VWF, F8
20bernard-soulier syndrome10.0F8, VWF
21glanzmann's thrombasthenia10.0F8, VWF
22vascular disease10.0VWF, PLAT
23prion disease10.0F8, VWF
24hypersensitivity reaction type ii disease9.9VWF, F8
25hypothyroidism9.9F8, VWF
26congenital heart disease9.9VWF, F8
27thrombocytopenia9.9VWF, F8
28coronary artery anomaly9.9VWF, PLAT
29primary hyperoxaluria9.8F8, VWF
30antiphospholipid syndrome9.8PLAT, VWF, F8
31thrombophilia9.8VWF, PLAT, F8
32thromboembolism9.8PLAT, F8, VWF
33hyperhomocysteinemia9.8F8, VWF, PLAT
34venous thrombosis9.8PLAT, F8, VWF
35factor v leiden thrombophilia9.8VWF, F8, PLAT
36pre-eclampsia9.8PLAT, F8, VWF
37type 2 diabetes mellitus9.8PLAT, F8, VWF
38cerebrovascular disease9.8VWF, F8, PLAT
39myocardial infarction9.8VWF, PLAT, F8
40insulin resistance9.8PLAT, VWF, F8
41diabetes mellitus9.7VWF, PLAT, F8
42systemic lupus erythematosus9.7VWF, F8

Graphical network of the top 20 diseases related to Type 3 Von Willebrand Disease:



Diseases related to type 3 von willebrand disease

Symptoms for Type 3 Von Willebrand Disease

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Drugs & Therapeutics for Type 3 Von Willebrand Disease

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Drug clinical trials:

Search ClinicalTrials for Type 3 Von Willebrand Disease

Search NIH Clinical Center for Type 3 Von Willebrand Disease

Genetic Tests for Type 3 Von Willebrand Disease

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Genetic tests related to Type 3 Von Willebrand Disease:

id Genetic test Affiliating Genes
1 Type 3 Von Willebrand Disease20

Anatomical Context for Type 3 Von Willebrand Disease

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Animal Models for Type 3 Von Willebrand Disease or affiliated genes

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MGI Mouse Phenotypes related to Type 3 Von Willebrand Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053978.5PLAT, F8, VWF

Publications for Type 3 Von Willebrand Disease

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Articles related to Type 3 Von Willebrand Disease:

(show all 11)
idTitleAuthorsYear
1
The genetics of Canadian type 3 von Willebrand disease: further evidence for co-dominant inheritance of mutant alleles. (23311757)
2013
2
Phenotypic and molecular characterisation of type 3 von Willebrand disease in a cohort of Indian patients. (23407766)
2013
3
Molecular characterization, recombinant protein expression, and mRNA analysis of type 3 von Willebrand disease: Studies of an Italian cohort of 10 patients. (22674667)
2012
4
Common large partial VWF gene deletion does not cause alloantibody formation in the Hungarian type 3 von Willebrand disease population. (21362127)
2011
5
Undetected factor VIII in a patient with type 3 von Willebrands disease mistaken as severe haemophilia A. (19563498)
2009
6
An Alu-mediated novel large deletion is the most frequent cause of type 3 von Willebrand disease in Hungary. (18665926)
2008
7
Long-term prophylaxis with intermediate-purity factor VIII concentrate (Haemate P) in a patient with type 3 von Willebrand disease and recurrent gastrointestinal bleeding. (16409182)
2006
8
Hemorrhagic symptoms and bleeding risk in obligatory carriers of type 3 von Willebrand disease: an international, multicenter study. (16999850)
2006
9
Molecular defects in type 3 von Willebrand disease: updated results from 40 multiethnic patients. (12737944)
2003
10
Local and systemic effects of intra-arterial desmopressin in healthy volunteers and patients with type 3 von Willebrand disease. Role of interleukin-6. (10959689)
2000
11
Mapping and functional studies of two alloantibodies developed in patients with type 3 von Willebrand disease. (10739386)
2000

Variations for Type 3 Von Willebrand Disease

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Expression for genes affiliated with Type 3 Von Willebrand Disease

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Expression patterns in normal tissues for genes affiliated with Type 3 Von Willebrand Disease

Search GEO for disease gene expression data for Type 3 Von Willebrand Disease.

Pathways for genes affiliated with Type 3 Von Willebrand Disease

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Pathways related to Type 3 Von Willebrand Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.0F8, VWF
2
Show member pathways
8.5VWF, F8, PLAT
3
Show member pathways
Complement Activation, Classical Pathway37
Complement and Coagulation Cascades37
8.5VWF, F8, PLAT
4
Show member pathways
8.5PLAT, F8, VWF

Compounds for genes affiliated with Type 3 Von Willebrand Disease

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Compounds related to Type 3 Von Willebrand Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 66)
idCompoundScoreTop Affiliating Genes
1integrilin449.8VWF, PLAT
2beraprost sodium449.7PLAT, VWF
3quinapril44 50 1111.7VWF, PLAT
4ppack449.7VWF, PLAT
5tirofiban44 1110.7PLAT, VWF
6perindopril44 50 1111.7PLAT, VWF
7ticlopidine44 1110.7PLAT, VWF
8abciximab44 1110.7VWF, PLAT
9ethidium bromide449.7PLAT, VWF
10clopidogrel44 50 24 1112.7PLAT, VWF
11dermatan sulfate449.7PLAT, VWF
12thromboxane44 2410.7PLAT, VWF
13kininogen449.6VWF, PLAT
14fluvastatin44 50 28 1112.6PLAT, VWF
15losartan44 50 28 1112.6PLAT, VWF
16pge1449.6VWF, PLAT
17aprotinin44 1110.5PLAT, VWF
18recombinate449.5VWF, F8
19tributylphosphate449.5VWF, F8
20kogenate449.5VWF, F8
21rfviii449.5VWF, F8
22sodium nitroprusside449.4PLAT, VWF
23hydroxyethyl starch449.4F8, VWF
24propranolol44 28 50 24 1113.4PLAT, F8
25atorvastatin44 50 28 24 1113.4VWF, PLAT
26ivig449.4F8, VWF
27simvastatin44 50 61 28 24 1114.3PLAT, VWF
28rituximab44 50 1111.3VWF, F8
29acetaminophen44 2 50 24 1113.3F8, VWF
30latex449.2VWF, F8
31prednisolone44 28 1111.0VWF, F8
32tranexamic acid44 1110.0PLAT, F8, VWF
33ristocetin449.0PLAT, F8, VWF
34desmopressin44 61 28 1112.0VWF, F8, PLAT
35hirudin449.0PLAT, F8, VWF
36warfarin44 50 24 1112.0PLAT, F8, VWF
37thromboxane a244 249.9PLAT, F8, VWF
38homocysteine44 249.9PLAT, F8, VWF
39citrate448.9F8, VWF
40prostacyclin448.9PLAT, F8, VWF
41aspirin44 50 28 2411.9VWF, F8, PLAT
42fibrinogen448.9PLAT, F8, VWF
43cyclosporin a44 28 6110.9VWF, F8, PLAT
44creatinine448.9VWF, F8, PLAT
45aspartate448.9PLAT, F8, VWF
46heparin44 28 24 1111.9PLAT, F8, VWF
47cholesterol44 28 24 1111.9VWF, F8, PLAT
48adp44 28 2410.8PLAT, F8, VWF
49agarose448.7F8, VWF
50cysteine448.7PLAT, F8, VWF

GO Terms for genes affiliated with Type 3 Von Willebrand Disease

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Cellular components related to Type 3 Von Willebrand Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrixGO:0310129.3PLAT, VWF
2platelet alpha granule lumenGO:0310938.9F8, VWF
3extracellular regionGO:0055768.2PLAT, F8, VWF

Biological processes related to Type 3 Von Willebrand Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1blood coagulation, intrinsic pathwayGO:0075979.0F8, VWF
2platelet activationGO:0301689.0F8, VWF
3platelet degranulationGO:0025768.7F8, VWF
4blood coagulationGO:0075968.4PLAT, F8, VWF

Molecular functions related to Type 3 Von Willebrand Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1serine-type endopeptidase activityGO:0042529.1PLAT, F8

Products for genes affiliated with Type 3 Von Willebrand Disease

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  • Antibodies
  • Proteins
  • Lysates

Sources for Type 3 Von Willebrand Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet