MCID: TYP024
MIFTS: 47

Type Ii Mixed Cryoglobulinemia malady

Genetic diseases, Neuronal diseases, Nephrological diseases, Respiratory diseases, Bone diseases, Rare diseases categories

Summaries for Type Ii Mixed Cryoglobulinemia

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MalaCards: Type Ii Mixed Cryoglobulinemia, also known as mc type ii, is related to cryoglobulinemia and hepatitis. An important gene associated with Type Ii Mixed Cryoglobulinemia is CD5 (CD5 molecule), and among its related pathways are Calcineurin-regulated NFAT-dependent transcription in lymphocytes and Immune response Role of integrins in NK cells cytotoxicity. The compounds amoxicillin and bosentan have been mentioned in the context of this disorder. Affiliated tissues include bone, b cells and lymph node, and related mouse phenotypes are normal and renal/urinary system.

Aliases & Classifications for Type Ii Mixed Cryoglobulinemia

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50Orphanet, 27ICD10 via Orphanet
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Related Diseases for Type Ii Mixed Cryoglobulinemia

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18GeneCards, 19GeneDecks
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Diseases in the Type Ii Mixed Cryoglobulinemia family:

Cryoglobulinemia, Familial Mixed Mixed Cryoglobulinemia Type Iii

Diseases related to Type Ii Mixed Cryoglobulinemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 76)
idRelated DiseaseScoreTop Affiliating Genes
1cryoglobulinemia31.7CD5, CD40LG
2hepatitis31.2FAS, FASLG, HLA-DRB1
3hepatitis c31.2CD40LG, HLA-DRB1, FAS
4vasculitis30.8CD40LG, FN1
5non-hodgkin lymphoma30.3FAS, CD5, HLA-DRB1
6hepatitis c virus10.8
7glomerulonephritis10.4
8b-cell lymphomas10.4
9membranoproliferative glomerulonephritis10.3
10pyoderma gangrenosum10.3
11retinal vasculitis10.3
12cerebritis10.3
13proliferative glomerulonephritis10.3
14hodgkin's lymphoma10.3
15liver disease10.3
16neuropathy10.3
17pyoderma10.3
18retinitis10.3
19scleritis10.3
20indolent b cell lymphoma10.3
21hiv-110.3
22macroglobulinemia10.1CD5
23narcolepsy10.1HLA-DRB1
24lupus erythematosus10.1CD40LG
25cryoglobulinemic vasculitis10.1CD5, CD40LG
26immunoglobulin alpha deficiency10.1HLA-DQB1, CD40LG
27multiple sclerosis 110.0HLA-DQB1, HLA-DRB1
28leptospirosis10.0CD40LG, FN1
29juvenile rheumatoid arthritis10.0HLA-DQB1, HLA-DRB1
30pulmonary tuberculosis10.0HLA-DRB1, HLA-DQB1
31thyroiditis10.0HLA-DRB1, FASLG
32type 1 diabetes mellitus10.0FASLG, HLA-DRB1
33hepatitis b10.0HLA-DRB1, HLA-DQB1
34lupus nephritis10.0FN1, CD40LG
35skin disease10.0HLA-DRB1, FN1
36toxic epidermal necrolysis10.0FAS, FASLG
37silicosis10.0FASLG, FAS
38lymphomatoid papulosis10.0FASLG, FAS
39stevens-johnson syndrome10.0FASLG, FAS
40encephalomyelitis10.0HLA-DQB1, FASLG
41iga glomerulonephritis10.0CD40LG, FN1
42autoimmune lymphoproliferative syndrome10.0FASLG, FAS
43nephritis10.0CD40LG, FN1
44cutaneous t cell lymphoma10.0CD5, FAS
45aplastic anemia10.0FASLG, FAS
46lymphopenia10.0FASLG, FAS
47autoimmune thyroiditis10.0FAS, FASLG
48primary biliary cirrhosis10.0HLA-DRB1, CD40LG
49systemic scleroderma10.0CD40LG, HLA-DRB1, HLA-DQB1
50multiple sclerosis10.0FASLG, HLA-DQB1, HLA-DRB1

Graphical network of the top 20 diseases related to Type Ii Mixed Cryoglobulinemia:



Diseases related to type ii mixed cryoglobulinemia

Symptoms for Type Ii Mixed Cryoglobulinemia

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Drugs & Therapeutics for Type Ii Mixed Cryoglobulinemia

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Type Ii Mixed Cryoglobulinemia

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Anatomical Context for Type Ii Mixed Cryoglobulinemia

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34MalaCards
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MalaCards organs/tissues related to Type Ii Mixed Cryoglobulinemia:

34
Bone, B cells, Lymph node, Bone marrow, Brain, Liver

Animal Models for Type Ii Mixed Cryoglobulinemia or affiliated genes

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38MGI
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Publications for Type Ii Mixed Cryoglobulinemia

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53PubMed
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Articles related to Type Ii Mixed Cryoglobulinemia:

(show all 46)
idTitleAuthorsYear
1
Scleritis and retinal vasculitis associated with a type II mixed cryoglobulinemia. (24259719)
2013
2
HCV proteins and immunoglobulin variable gene (IgV) subfamilies in HCV-induced type II mixed cryoglobulinemia: a concurrent pathogenetic role. (22690241)
2012
3
Molecular signatures of hepatitis C virus (HCV)-induced type II mixed cryoglobulinemia (MCII). (23202510)
2012
4
Parvovirus B19-induced type II mixed cryoglobulinemia. (21854885)
2011
5
Clinical spectrum, treatment, and outcome of patients with type II mixed cryoglobulinemia without evidence of hepatitis C infection. (21239761)
2011
6
An experimental type II mixed cryoglobulinemia with renal glomerulopathy in ICR mice triggered by Capillaria hepatica infection. (21972091)
2011
7
HLA DR-DQ combination associated with the increased risk of developing human HCV positive non-Hodgkin's lymphoma is related to the type II mixed cryoglobulinemia. (20002609)
2010
8
Characterization of antibodies directed against the immunoglobulin light kappa chain variable chain region (VK) of hepatitis C virus-related type-II mixed cryoglobulinemia and B-cell proliferations. (19758144)
2009
9
Hepatitis C virus-associated type II mixed cryoglobulinemia vasculitis complicated with membranous proliferative glomerulonephritis. (19212913)
2009
10
Essential type II mixed cryoglobulinemia causing pyoderma gangrenosum-like ulcers. (18335149)
2008
11
Fibronectin gene polymorphisms are associated with the development of B-cell lymphoma in type II mixed cryoglobulinemia. (17526550)
2008
12
Efficacy and risk of rituximab in type II mixed cryoglobulinemia: a significant case report. (17936216)
2007
13
Genetic insights into the disease mechanisms of type II mixed cryoglobulinemia induced by hepatitis C virus. (17936227)
2007
14
The use of monoclonal antibody (rituximab) in the treatment of type II mixed cryoglobulinemia. (17625752)
2007
15
Paradoxical brain embolism associated with HCV-related type II mixed cryoglobulinemia. (17493820)
2007
16
HCV-related immunocytoma and type II mixed cryoglobulinemia-associated autoantigens. (17911427)
2007
17
HCV-NS3 and IgG-Fc crossreactive IgM in patients with type II mixed cryoglobulinemia and B-cell clonal proliferations. (16617326)
2006
18
Transfusion-associated TT virus co-infection in patients with hepatitis C virus is associated with type II mixed cryoglobulinemia but not with B-cell non-Hodgkin lymphoma. (12691541)
2003
19
Cerebral vasculitis in a patient with HCV-related type II mixed cryoglobulinemia. (12968400)
2003
20
Efficacy and safety of rituximab in type II mixed cryoglobulinemia. (12560225)
2003
21
Influence of age and autoimmunity on liver disease in HCV-associated type II mixed cryoglobulinemia. (12175729)
2002
22
Severe cutaneous vasculitis following intravenous infusion of gammaglobulin in a patient with type II mixed cryoglobulinemia. (12051404)
2002
23
Characterization of cryoglobulin, M protein, low molecular weight IgM in a patient with chronic hepatitis C and type II mixed cryoglobulinemia]. (11769562)
2001
24
Membranoproliferative glomerulonephritis and demyelinating neuropathy caused by type II mixed cryoglobulinemia associated with HCV infection. (10830181)
2000
25
Oligoclonal non-neoplastic B cell expansion is the key feature of type II mixed cryoglobulinemia: clinical and molecular findings do not support a bone marrow pathologic diagnosis of indolent B cell lymphoma. (10643704)
2000
26
Peri-lesional injections of granulocyte-macrophage colony-stimulating factor in the management of chronic leg ulcers in type II mixed cryoglobulinemia. (10980654)
2000
27
Splenectomy may improve the glomerulopathy of type II mixed cryoglobulinemia. (10845834)
2000
28
Lack of Fas and Fas-L mutations in patients with lymphoproliferative disorders associated with SjAPgren's syndrome and type II mixed cryoglobulinemia. (10410268)
1999
29
Rituximab for the treatment of type II mixed cryoglobulinemia. (10586221)
1999
30
Failure of cyclosporin therapy in type II mixed cryoglobulinemia associated with hepatitis C virus infection. (9706447)
1998
31
Interferon for hepatitis C virus-negative type II mixed cryoglobulinemia. (9575053)
1998
32
Asymptomatic type II mixed cryoglobulinemia with a very high cryocrit level secondary to HCV infection. (9779567)
1998
33
GB virus C infection in patients with type II mixed cryoglobulinemia. (9382367)
1997
34
Detection and distribution of hepatitis C virus-related proteins in lymph nodes of patients with type II mixed cryoglobulinemia and neoplastic or non-neoplastic lymphoproliferation. (8977256)
1996
35
Hepatitis C virus genotype analysis in patients with type II mixed cryoglobulinemia. (7503475)
1996
36
Type II mixed cryoglobulinemia treated with fludarabine. (8730157)
1996
37
Lymph node angiogenesis in lymphoproliferative disorders: type II Mixed cryoglobulinemia as a model. (8730490)
1995
38
Hepatitis C virus within a malignant lymphoma lesion in the course of type II mixed cryoglobulinemia. (7655017)
1995
39
Disappearance of cryoglobulins and remission of symptoms in a patient with HCV-associated type II mixed cryoglobulinemia after HIV-1 infection. (8730498)
1995
40
A pilot study on the effectiveness of cyclosporine in type II mixed cryoglobulinemia. (8730507)
1995
41
HLA expression in type II mixed cryoglobulinemia and chronic hepatitis C virus. (8730485)
1995
42
Lymphoproliferation in type II mixed cryoglobulinemia. (8730495)
1995
43
Natural interferon-alpha versus its combination with 6-methyl-prednisolone in the therapy of type II mixed cryoglobulinemia: a long-term, randomized, controlled study. (7524736)
1994
44
Long-term effects of alpha-interferon therapy for type II mixed cryoglobulinemia. (7528704)
1994
45
High prevalence of hepatitis C virus RNA in the supernatant and the cryoprecipitate of patients with essential and secondary type II mixed cryoglobulinemia. (7525697)
1994
46
Hepatitis C virus infection in type II mixed cryoglobulinemia. (8216392)
1993

Variations for Type Ii Mixed Cryoglobulinemia

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Expression for genes affiliated with Type Ii Mixed Cryoglobulinemia

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Type Ii Mixed Cryoglobulinemia

Search GEO for disease gene expression data for Type Ii Mixed Cryoglobulinemia.

Pathways for genes affiliated with Type Ii Mixed Cryoglobulinemia

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51PathCards, 39NCBI BioSystems Database, 61Thomson Reuters, 31KEGG, 56Reactome, 54QIAGEN, 55R&D Systems, 58SinoBiological
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Pathways related to Type Ii Mixed Cryoglobulinemia according to GeneCards/GeneDecks:

(show all 26)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Calcium signaling in the CD4+ TCR pathway39
9.5CD40LG, FASLG
29.5FASLG, FN1
39.5HLA-DRB1, CD5
4
Show member pathways
9.4HLA-DRB1, HLA-DQB1
5
Show member pathways
9.4HLA-DRB1, HLA-DQB1
69.4HLA-DRB1, HLA-DQB1
79.4HLA-DRB1, HLA-DQB1
8
Show member pathways
Immune response IL 22 signaling pathway61
G protein signaling N RAS regulation pathway61
9.4HLA-DRB1, HLA-DQB1
99.4CD40LG, FN1
10
Show member pathways
Immune response IL 12 induced IFN gamma production61
9.4FASLG, HLA-DRB1
11
Show member pathways
FAS pathway and Stress induction of HSP regulation39
Apoptosis and survival FAS signaling cascades61
Caspase cascade in apoptosis39
9.2FASLG, FAS
12
Show member pathways
Transcription NF kB signaling pathway61
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response61
9.2FASLG, FAS
13
Show member pathways
TRAIL signaling pathway39
9.2FAS, FASLG
14
Show member pathways
Apoptosis and survival Apoptotic TNF family pathways61
9.2FASLG, FAS
159.2FASLG, FAS
16
Show member pathways
9.2FASLG, FAS
17
Show member pathways
9.2FASLG, FAS
189.2FASLG, FAS
198.9HLA-DQB1, HLA-DRB1, CD40LG
20
Show member pathways
8.9HLA-DQB1, HLA-DRB1, CD40LG
21
Show member pathways
8.9CD40LG, HLA-DRB1, HLA-DQB1
228.7FN1, FAS, FASLG
238.7FN1, FAS, FASLG
24
Show member pathways
8.3HLA-DQB1, FAS, FASLG, CD40LG
25
Show member pathways
8.2FASLG, FAS, HLA-DRB1, HLA-DQB1
26
Show member pathways
7.6CD40LG, FASLG, FAS, HLA-DRB1, HLA-DQB1

Compounds for genes affiliated with Type Ii Mixed Cryoglobulinemia

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46Novoseek, 52PharmGKB, 12DrugBank, 30IUPHAR, 25HMDB, 62Tocris Bioscience, 3BitterDB
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Compounds related to Type Ii Mixed Cryoglobulinemia according to GeneCards/GeneDecks:

(show top 50)    (show all 81)
idCompoundScoreTop Affiliating Genes
1amoxicillin46 52 1211.9HLA-DQB1, CD40LG
2bosentan46 1210.9FN1, FASLG
3pmma469.6FN1, CD40LG
4(glc)4469.6FASLG, FAS
5atpo30 4610.6FAS, FASLG
6silicone469.5CD40LG, FN1
7teniposide46 1210.5FAS, FASLG
8biotin46 25 1211.4FN1, FASLG, CD40LG
9hyaluronic acid46 2510.3CD40LG, FASLG, FN1
10concanamycin a46 6210.2FASLG, FAS
11gliadin469.2FAS, HLA-DQB1, CD40LG
122-chlorodeoxyadenosine469.1CD40LG, FAS, FASLG
13fludarabine46 52 1211.1CD40LG, FASLG, FAS
14ivig469.1CD40LG, FAS, FASLG
15rottlerin469.1FASLG, CD40LG, FAS
16tetracycline46 1210.1CD40LG, FAS, FASLG
17adriamycin469.1FAS, FN1, FASLG
18tgf beta1469.1FASLG, FN1, FAS
19ionomycin469.0FAS, CD40LG, FASLG
20phosphatidylserine46 30 1211.0FAS, FASLG, CD40LG
21herbimycin a46 6210.0FN1, FAS, CD40LG
22rantes468.9CD40LG, FASLG, FAS
23aspirin46 52 30 2511.9CD40LG, FAS, FN1
24epinephrine46 25 1210.9FAS, CD40LG, FASLG
25n acetylcysteine468.9FASLG, FAS, CD40LG
26ascorbic acid46 259.8FAS, FASLG, CD40LG
27glutamate468.7HLA-DQB1, HLA-DRB1, FASLG, CD40LG
28sb 20358046 629.7FN1, FASLG, FAS
29aspartate468.7CD40LG, FAS, HLA-DQB1, FASLG
30alanine468.6CD40LG, HLA-DRB1, FN1, FASLG
31agar468.6FASLG, CD40LG, FAS, FN1
32indomethacin46 30 62 1211.6CD40LG, FASLG, FAS, FN1
33polysaccharide468.6FN1, FASLG, FAS, CD40LG
34rapamycin468.6FN1, FAS, FASLG, CD40LG
35doxorubicin46 52 1210.6FAS, CD40LG, FASLG, FN1
36actinomycin d468.6FN1, FASLG, CD40LG, FAS
37butyrate468.6FASLG, FAS, FN1
38genistein46 30 62 3 25 1213.6FN1, CD40LG, FAS, FASLG
39cyclosporin a46 30 6210.6CD40LG, FN1, FAS, FASLG
40lactate468.6FN1, CD40LG, FASLG, FAS
41cisplatin46 52 62 1211.6FN1, FASLG, CD40LG, FAS
42heparin46 30 25 1211.5CD40LG, FAS, FASLG, FN1
43oligonucleotide468.5FAS, FASLG, HLA-DRB1, HLA-DQB1
44dexamethasone46 52 30 1211.5FASLG, CD40LG, FAS, FN1
45vegf468.5FN1, FAS, FASLG, CD40LG
46arginine468.3CD40LG, FAS, FN1, HLA-DRB1
47paraffin468.2FASLG, CD40LG, CD5, FAS, FN1
48retinoic acid46 259.2CD40LG, FAS, FN1, FASLG
49cysteine467.9FN1, FAS, FASLG, CD40LG
50tyrosine467.7HLA-DQB1, FN1, FASLG, CD5, FAS, HLA-DRB1

GO Terms for genes affiliated with Type Ii Mixed Cryoglobulinemia

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17Gene Ontology
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Cellular components related to Type Ii Mixed Cryoglobulinemia according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1MHC class II protein complexGO:0426139.7HLA-DRB1, HLA-DQB1
2integral component of lumenal side of endoplasmic reticulum membraneGO:0715569.6HLA-DQB1, HLA-DRB1
3clathrin-coated endocytic vesicle membraneGO:0306699.6HLA-DRB1, HLA-DQB1
4transport vesicle membraneGO:0306589.6HLA-DQB1, HLA-DRB1
5ER to Golgi transport vesicle membraneGO:0125079.5HLA-DRB1, HLA-DQB1
6trans-Golgi network membraneGO:0325889.4HLA-DRB1, HLA-DQB1
7endocytic vesicle membraneGO:0306669.3HLA-DRB1, HLA-DQB1
8integral component of plasma membraneGO:0058878.7CD40LG, CD5, FASLG, HLA-DRB1
9external side of plasma membraneGO:0098977.9CD40LG, CD5, FASLG, FAS, HLA-DRB1
10extracellular vesicular exosomeGO:0700627.8FN1, HLA-DRB1, FAS, FASLG
11plasma membraneGO:0058867.7CD40LG, CD5, FAS, HLA-DRB1, HLA-DQB1

Biological processes related to Type Ii Mixed Cryoglobulinemia according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of endothelial cell apoptotic processGO:20003539.7CD40LG, FASLG
2immunoglobulin production involved in immunoglobulin mediated immune responseGO:0023819.7HLA-DQB1, HLA-DRB1
3humoral immune response mediated by circulating immunoglobulinGO:0024559.7HLA-DQB1, HLA-DRB1
4inflammatory cell apoptotic processGO:0069259.5FASLG, FAS
5necroptotic signaling pathwayGO:0975279.5FAS, FASLG
6interferon-gamma-mediated signaling pathwayGO:0603339.4HLA-DQB1, HLA-DRB1
7antigen processing and presentation of exogenous peptide antigen via MHC class IIGO:0198869.4HLA-DRB1, HLA-DQB1
8regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012399.4FAS, FASLG
9T cell costimulationGO:0312959.4CD5, HLA-DRB1, HLA-DQB1
10extrinsic apoptotic signaling pathway via death domain receptorsGO:0086259.3FASLG, FAS
11extrinsic apoptotic signaling pathwayGO:0971919.3FASLG, FAS
12T cell receptor signaling pathwayGO:0508529.1HLA-DRB1, HLA-DQB1
13activation of cysteine-type endopeptidase activity involved in apoptotic processGO:0069199.1FASLG, FAS
14apoptotic signaling pathwayGO:0971909.1CD5, FASLG, FAS
15immune responseGO:0069559.1FASLG, HLA-DRB1, HLA-DQB1

Molecular functions related to Type Ii Mixed Cryoglobulinemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tumor necrosis factor receptor bindingGO:0051649.5CD40LG, FASLG
2MHC class II receptor activityGO:0323959.1HLA-DRB1, HLA-DQB1

Products for genes affiliated with Type Ii Mixed Cryoglobulinemia

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  • Antibodies
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Sources for Type Ii Mixed Cryoglobulinemia

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet