MCID: TYP024
MIFTS: 35

Type Ii Mixed Cryoglobulinemia malady

Categories: Genetic diseases, Neuronal diseases, Cardiovascular diseases, Nephrological diseases, Respiratory diseases, Bone diseases, Rare diseases, Immune diseases

Aliases & Classifications for Type Ii Mixed Cryoglobulinemia

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Sources:
52Orphanet, 29ICD10 via Orphanet
See all MalaCards sources

Summaries for Type Ii Mixed Cryoglobulinemia

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MalaCards based summary: Type Ii Mixed Cryoglobulinemia, also known as mc type ii, is related to cryoglobulinemia and hepatitis. An important gene associated with Type Ii Mixed Cryoglobulinemia is HLA-DQB1 (Major Histocompatibility Complex, Class II, DQ Beta 1), and among its related pathways are CTLA4 Signaling and Rheumatoid arthritis. Affiliated tissues include bone, b cells and lymph node, and related mouse phenotypes are liver/biliary system and immune system.

Related Diseases for Type Ii Mixed Cryoglobulinemia

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Diseases in the Cryoglobulinemia, Familial Mixed family:

Mixed Cryoglobulinemia Type Iii type ii mixed cryoglobulinemia

Diseases related to Type Ii Mixed Cryoglobulinemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 79)
idRelated DiseaseScoreTop Affiliating Genes
1cryoglobulinemia10.7
2hepatitis10.5
3hepatitis c10.5
4hepatitis c virus10.4
5fruit allergy10.4HLA-DQB1, HLA-DRB1
6wolffian duct adenocarcinoma10.4HLA-DQB1, HLA-DRB1
7quinquaud's decalvans folliculitis10.4HLA-DQB1, HLA-DRB1
8parsonage turner syndrome10.4HLA-DQB1, HLA-DRB1
9myopathy-growth delay-intellectual disability-hypospadias syndrome10.4HLA-DQB1, HLA-DRB1
10vitreoretinochoroidopathy dominant10.4HLA-DQB1, HLA-DRB1
11krieble bixler syndrome10.4HLA-DQB1, HLA-DRB1
12limb dystonia10.4HLA-DQB1, HLA-DRB1
13spondylarthropathy10.4HLA-DQB1, HLA-DRB1
14mitochondrial encephalomyopathy10.4HLA-DQB1, HLA-DRB1
15rheumatic myocarditis10.4HLA-DQB1, HLA-DRB1
16ovarian papillary cystadenoma10.4HLA-DQB1, HLA-DRB1
17nebulin-related early-onset distal myopathy10.4HLA-DQB1, HLA-DRB1
18purpura fulminans10.4HLA-DQB1, HLA-DRB1
19lymphocytic colitis10.4HLA-DQB1, HLA-DRB1
20autoinflammation, lipodystrophy, and dermatosis syndrome10.4HLA-DQB1, HLA-DRB1
21peripheral t-cell lymphoma10.4HLA-DQB1, HLA-DRB1
22foster-kennedy syndrome10.4HLA-DQB1, HLA-DRB1
23thrombocytopenia due to platelet alloimmunization10.4HLA-DQB1, HLA-DRB1
24orbit alveolar rhabdomyosarcoma10.4HLA-DQB1, HLA-DRB1
25lipodermatosclerosis10.4HLA-DQB1, HLA-DRB1
26x-linked congenital generalized hypertrichosis10.4HLA-DQB1, HLA-DRB1
27aseptic osteitis10.4HLA-DQB1, HLA-DRB1
28idiopathic central precocious puberty10.3HLA-DQB1, HLA-DRB1
29oculogyric crisis10.3HLA-DQB1, HLA-DRB1
30sensorineural hearing loss10.3HLA-DQB1, HLA-DRB1
31mononeuritis of upper limb10.3HLA-DQB1, HLA-DRB1
32multicentric castleman disease10.3HLA-DQB1, HLA-DRB1
33allergic hypersensitivity disease10.3HLA-DQB1, HLA-DRB1
34hypoxia10.3HLA-DQB1, HLA-DRB1
35cirrhotic cardiomyopathy10.3HLA-DQB1, HLA-DRB1
36epidermolysis bullosa simplex superficialis10.3HLA-DQB1, HLA-DRB1
37achilles bursitis10.3HLA-DQB1, HLA-DRB1
38spinal atrophy ophthalmoplegia pyramidal syndrome10.2HLA-DQB1, HLA-DRB1
39lymphoma10.2
40cervical benign neoplasm10.2FASLG, HLA-DRB1
41breast carcinoma in situ10.2HLA-DQB1, HLA-DRB1
42vasculitis10.2
43retroperitoneal fibrosis10.1FASLG, HLA-DRB1
44subcorneal pustular dermatosis10.0HLA-DQB1, HLA-DRB1
45b-cell lymphomas10.0
46glomerulonephritis10.0
4712p12.1 microdeletion syndrome10.0FAS, FASLG
48granulomatous gastritis10.0FAS, FASLG
49adrenal cortical adenocarcinoma9.9FAS, FASLG
50metaphyseal dysplasia without hypotrichosis9.9FAS, FASLG

Graphical network of the top 20 diseases related to Type Ii Mixed Cryoglobulinemia:



Diseases related to type ii mixed cryoglobulinemia

Symptoms for Type Ii Mixed Cryoglobulinemia

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Drugs & Therapeutics for Type Ii Mixed Cryoglobulinemia

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Type Ii Mixed Cryoglobulinemia

Genetic Tests for Type Ii Mixed Cryoglobulinemia

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Anatomical Context for Type Ii Mixed Cryoglobulinemia

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MalaCards organs/tissues related to Type Ii Mixed Cryoglobulinemia:

34
Bone, B cells, Lymph node, Bone marrow, Liver, Brain

Animal Models for Type Ii Mixed Cryoglobulinemia or affiliated genes

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MGI Mouse Phenotypes related to Type Ii Mixed Cryoglobulinemia:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.5FAS, FASLG, FN1, HLA-DQB1
2MP:00053877.6CD5, FAS, FASLG, FN1, HLA-DQB1
3MP:00028737.6CD5, FAS, FASLG, FN1, HLA-DQB1
4MP:00053977.3CD5, FAS, FASLG, FN1, HLA-DQB1

Publications for Type Ii Mixed Cryoglobulinemia

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Articles related to Type Ii Mixed Cryoglobulinemia:

(show all 48)
idTitleAuthorsYear
1
Scleritis and retinal vasculitis associated with a type II mixed cryoglobulinemia. (24259719)
2013
2
HCV proteins and immunoglobulin variable gene (IgV) subfamilies in HCV-induced type II mixed cryoglobulinemia: a concurrent pathogenetic role. (22690241)
2012
3
Molecular signatures of hepatitis C virus (HCV)-induced type II mixed cryoglobulinemia (MCII). (23202510)
2012
4
Clinical spectrum, treatment, and outcome of patients with type II mixed cryoglobulinemia without evidence of hepatitis C infection. (21239761)
2011
5
Parvovirus B19-induced type II mixed cryoglobulinemia. (21854885)
2011
6
An experimental type II mixed cryoglobulinemia with renal glomerulopathy in ICR mice triggered by Capillaria hepatica infection. (21972091)
2011
7
HLA DR-DQ combination associated with the increased risk of developing human HCV positive non-Hodgkin's lymphoma is related to the type II mixed cryoglobulinemia. (20002609)
2010
8
Characterization of antibodies directed against the immunoglobulin light kappa chain variable chain region (VK) of hepatitis C virus-related type-II mixed cryoglobulinemia and B-cell proliferations. (19758144)
2009
9
Hepatitis C virus-associated type II mixed cryoglobulinemia vasculitis complicated with membranous proliferative glomerulonephritis. (19212913)
2009
10
Fibronectin gene polymorphisms are associated with the development of B-cell lymphoma in type II mixed cryoglobulinemia. (17526550)
2008
11
Essential type II mixed cryoglobulinemia causing pyoderma gangrenosum-like ulcers. (18335149)
2008
12
Paradoxical brain embolism associated with HCV-related type II mixed cryoglobulinemia. (17493820)
2007
13
Efficacy and risk of rituximab in type II mixed cryoglobulinemia: a significant case report. (17936216)
2007
14
Genetic insights into the disease mechanisms of type II mixed cryoglobulinemia induced by hepatitis C virus. (17936227)
2007
15
The use of monoclonal antibody (rituximab) in the treatment of type II mixed cryoglobulinemia. (17625752)
2007
16
HCV-related immunocytoma and type II mixed cryoglobulinemia-associated autoantigens. (17911427)
2007
17
HCV-NS3 and IgG-Fc crossreactive IgM in patients with type II mixed cryoglobulinemia and B-cell clonal proliferations. (16617326)
2006
18
Efficacy and safety of rituximab in type II mixed cryoglobulinemia. (12560225)
2003
19
Transfusion-associated TT virus co-infection in patients with hepatitis C virus is associated with type II mixed cryoglobulinemia but not with B-cell non-Hodgkin lymphoma. (12691541)
2003
20
Cerebral vasculitis in a patient with HCV-related type II mixed cryoglobulinemia. (12968400)
2003
21
Influence of age and autoimmunity on liver disease in HCV-associated type II mixed cryoglobulinemia. (12175729)
2002
22
Rituximab for the treatment of type II mixed cryoglobulinemia. (12209536)
2002
23
Severe cutaneous vasculitis following intravenous infusion of gammaglobulin in a patient with type II mixed cryoglobulinemia. (12051404)
2002
24
Characterization of cryoglobulin, M protein, low molecular weight IgM in a patient with chronic hepatitis C and type II mixed cryoglobulinemia]. (11769562)
2001
25
Splenectomy may improve the glomerulopathy of type II mixed cryoglobulinemia. (10845834)
2000
26
Membranoproliferative glomerulonephritis and demyelinating neuropathy caused by type II mixed cryoglobulinemia associated with HCV infection. (10830181)
2000
27
Oligoclonal non-neoplastic B cell expansion is the key feature of type II mixed cryoglobulinemia: clinical and molecular findings do not support a bone marrow pathologic diagnosis of indolent B cell lymphoma. (10643704)
2000
28
Peri-lesional injections of granulocyte-macrophage colony-stimulating factor in the management of chronic leg ulcers in type II mixed cryoglobulinemia. (10980654)
2000
29
Lack of Fas and Fas-L mutations in patients with lymphoproliferative disorders associated with SjAPgren's syndrome and type II mixed cryoglobulinemia. (10410268)
1999
30
Rituximab for the treatment of type II mixed cryoglobulinemia. (10586221)
1999
31
Asymptomatic type II mixed cryoglobulinemia with a very high cryocrit level secondary to HCV infection. (9779567)
1998
32
Failure of cyclosporin therapy in type II mixed cryoglobulinemia associated with hepatitis C virus infection. (9706447)
1998
33
Interferon for hepatitis C virus-negative type II mixed cryoglobulinemia. (9575053)
1998
34
GB virus C infection in patients with type II mixed cryoglobulinemia. (9382367)
1997
35
Hepatitis C virus genotype analysis in patients with type II mixed cryoglobulinemia. (7503475)
1996
36
Detection and distribution of hepatitis C virus-related proteins in lymph nodes of patients with type II mixed cryoglobulinemia and neoplastic or non-neoplastic lymphoproliferation. (8977256)
1996
37
Type II mixed cryoglobulinemia treated with fludarabine. (8730157)
1996
38
Disappearance of cryoglobulins and remission of symptoms in a patient with HCV-associated type II mixed cryoglobulinemia after HIV-1 infection. (8730498)
1995
39
A pilot study on the effectiveness of cyclosporine in type II mixed cryoglobulinemia. (8730507)
1995
40
HLA expression in type II mixed cryoglobulinemia and chronic hepatitis C virus. (8730485)
1995
41
Lymph node angiogenesis in lymphoproliferative disorders: type II Mixed cryoglobulinemia as a model. (8730490)
1995
42
Hepatitis C virus within a malignant lymphoma lesion in the course of type II mixed cryoglobulinemia. (7655017)
1995
43
Low prevalence of hepatitis E virus in type II mixed cryoglobulinemia. (8647527)
1995
44
Lymphoproliferation in type II mixed cryoglobulinemia. (8730495)
1995
45
Natural interferon-alpha versus its combination with 6-methyl-prednisolone in the therapy of type II mixed cryoglobulinemia: a long-term, randomized, controlled study. (7524736)
1994
46
Long-term effects of alpha-interferon therapy for type II mixed cryoglobulinemia. (7528704)
1994
47
High prevalence of hepatitis C virus RNA in the supernatant and the cryoprecipitate of patients with essential and secondary type II mixed cryoglobulinemia. (7525697)
1994
48
Hepatitis C virus infection in type II mixed cryoglobulinemia. (8216392)
1993

Variations for Type Ii Mixed Cryoglobulinemia

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Expression for genes affiliated with Type Ii Mixed Cryoglobulinemia

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Search GEO for disease gene expression data for Type Ii Mixed Cryoglobulinemia.

Pathways for genes affiliated with Type Ii Mixed Cryoglobulinemia

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Pathways related to Type Ii Mixed Cryoglobulinemia according to GeneCards Suite gene sharing:

(show all 15)
idSuper pathwaysScoreTop Affiliating Genes
19.6HLA-DQB1, HLA-DRB1
29.6HLA-DQB1, HLA-DRB1
39.6HLA-DQB1, HLA-DRB1
49.4FASLG, FN1
59.4CD5, HLA-DRB1
69.1FAS, FASLG
7
Show member pathways
9.1FAS, FASLG
89.1FAS, FASLG
9
Show member pathways
8.7FAS, FASLG, HLA-DQB1
10
Show member pathways
8.6FAS, FASLG, FN1
11
Show member pathways
8.6FAS, FASLG, FN1
128.6FAS, FASLG, FN1
138.6FAS, FASLG, FN1
14
Show member pathways
8.3FAS, FASLG, HLA-DQB1, HLA-DRB1
15
Show member pathways
8.3FAS, FASLG, HLA-DQB1, HLA-DRB1

GO Terms for genes affiliated with Type Ii Mixed Cryoglobulinemia

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Cellular components related to Type Ii Mixed Cryoglobulinemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1MHC class II protein complexGO:004261310.1HLA-DQB1, HLA-DRB1
2integral component of lumenal side of endoplasmic reticulum membraneGO:007155610.1HLA-DQB1, HLA-DRB1
3clathrin-coated endocytic vesicle membraneGO:003066910.0HLA-DQB1, HLA-DRB1
4ER to Golgi transport vesicle membraneGO:001250710.0HLA-DQB1, HLA-DRB1
5trans-Golgi network membraneGO:00325889.9HLA-DQB1, HLA-DRB1
6transport vesicle membraneGO:00306589.7HLA-DQB1, HLA-DRB1
7endocytic vesicle membraneGO:00306669.6HLA-DQB1, HLA-DRB1
8external side of plasma membraneGO:00098978.2CD5, FAS, FASLG

Biological processes related to Type Ii Mixed Cryoglobulinemia according to GeneCards Suite gene sharing:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1interferon-gamma-mediated signaling pathwayGO:006033310.1HLA-DQB1, HLA-DRB1
2inflammatory cell apoptotic processGO:00069259.8FAS, FASLG
3necroptotic signaling pathwayGO:00975279.7FAS, FASLG
4activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathwayGO:00972969.7FAS, FASLG
5response to growth factorGO:00708489.7FAS, FASLG
6regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:19020419.6FAS, FASLG
7extrinsic apoptotic signaling pathwayGO:00971919.6FAS, FASLG
8cellular response to glucose stimulusGO:00713339.6FAS, FN1
9cellular response to interleukin-1GO:00713479.5FAS, FN1
10negative regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:19020429.5FAS, FASLG
11activation of cysteine-type endopeptidase activity involved in apoptotic processGO:00069199.2FAS, FASLG
12extrinsic apoptotic signaling pathway via death domain receptorsGO:00086259.1FAS, FASLG
13immune responseGO:00069558.7FAS, FASLG, HLA-DQB1
14T cell costimulationGO:00312958.7CD5, HLA-DQB1, HLA-DRB1
15apoptotic signaling pathwayGO:00971908.4CD5, FAS, FASLG

Molecular functions related to Type Ii Mixed Cryoglobulinemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1peptide antigen bindingGO:00426059.6HLA-DQB1, HLA-DRB1

Sources for Type Ii Mixed Cryoglobulinemia

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet