MCID: TYP024
MIFTS: 36

Type Ii Mixed Cryoglobulinemia malady

Neuronal diseases, Nephrological diseases, Respiratory diseases, Bone diseases categories

Summaries for Type Ii Mixed Cryoglobulinemia

About this section
Sources:
32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MalaCards: Type Ii Mixed Cryoglobulinemia, also known as mc type ii, is related to cryoglobulinemia and hepatitis. An important gene associated with Type Ii Mixed Cryoglobulinemia is CD5 (CD5 molecule), and among its related pathways are Proteoglycans in cancer and Immune response Role of integrins in NK cells cytotoxicity. The compounds gliadin and indomethacin have been mentioned in the context of this disorder. Affiliated tissues include bone, and related mouse phenotypes are renal/urinary system and reproductive system.

Aliases & Classifications for Type Ii Mixed Cryoglobulinemia

About this section
Sources:
48Orphanet, 26ICD10 via Orphanet
See all sources

Classifications:



Characteristics (Orphanet epidemiological data):

48
type ii mixed cryoglobulinemia:
Age of onset: Variable


Aliases & Descriptions:

type ii mixed cryoglobulinemia 48
mc type ii 48


External Ids:

ICD10 via Orphanet26 D89.1

Related Diseases for Type Ii Mixed Cryoglobulinemia

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Type Ii Mixed Cryoglobulinemia family:

Cryoglobulinemia, Familial Mixed Mixed Cryoglobulinemia Type Iii

Diseases related to Type Ii Mixed Cryoglobulinemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 118)
idRelated DiseaseScoreTop Affiliating Genes
1cryoglobulinemia31.6CD5, CD40LG
2hepatitis31.2HLA-DRB1, FASLG, FAS
3hepatitis c31.2CD40LG, HLA-DRB1, FAS
4vasculitis30.7CD40LG, FN1
5glomerulonephritis30.5FN1, CD40LG
6hepatitis b30.5HLA-DRB1, HLA-DQB1
7non-hodgkin lymphoma30.3FAS, HLA-DRB1, CD5, BCR
8hepatitis a10.4
9membranous glomerulonephritis10.2
10membranoproliferative glomerulonephritis10.2
11hepatitis e10.2
12cerebritis10.2
13proliferative glomerulonephritis10.2
14bone lymphoma10.2
15pyoderma gangrenosum10.2
16retinal vasculitis10.2
17hodgkin's lymphoma10.2
18liver disease10.2
19neuropathy10.2
20pyoderma10.2
21retinitis10.2
22scleritis10.2
23celiac disease10.0HLA-DQB1
24myasthenia gravis10.0HLA-DQB1
25acute leukemia10.0BCR
26cervical cancer10.0HLA-DQB1
27human immunodeficiency virus infectious disease10.0FASLG
28lupus erythematosus10.0CD40LG
29endometriosis10.0FN1
30guillain-barre syndrome10.0CD40LG
31measles10.0CD40LG
32sarcoma10.0FN1
33common variable immune deficiency10.0CD40LG
34schistosomiasis10.0CD40LG
35glaucoma10.0FN1
36osteoarthritis10.0FN1
37hypertension10.0FN1
38lung cancer10.0FN1
39cystic fibrosis10.0FN1
40diabetic retinopathy10.0FN1
41lyme disease10.0CD40LG
42rubella10.0CD40LG
43pemphigus foliaceus10.0HLA-DRB1
44antiphospholipid syndrome10.0CD40LG
45malaria10.0HLA-DRB1
46pemphigus vulgaris10.0HLA-DRB1
47toxoplasmosis10.0CD40LG
48periodontal disease10.0FN1
49encephalomyelitis10.0FASLG, HLA-DQB1
50thrombocytopenia10.0CD40LG

Graphical network of the top 20 diseases related to Type Ii Mixed Cryoglobulinemia:



Diseases related to type ii mixed cryoglobulinemia

Clinical Features for Type Ii Mixed Cryoglobulinemia

About this section

Drugs & Therapeutics for Type Ii Mixed Cryoglobulinemia

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Type Ii Mixed Cryoglobulinemia

Drug clinical trials:

Search ClinicalTrials for Type Ii Mixed Cryoglobulinemia

Search NIH Clinical Center for Type Ii Mixed Cryoglobulinemia

Search CenterWatch for Type Ii Mixed Cryoglobulinemia

Genetic Tests for Type Ii Mixed Cryoglobulinemia

About this section

Anatomical Context for Type Ii Mixed Cryoglobulinemia

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Type Ii Mixed Cryoglobulinemia:

32
Bone

Animal Models for Type Ii Mixed Cryoglobulinemia or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Type Ii Mixed Cryoglobulinemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000536710.1HLA-DQB1
2MP:00053898.9FAS, FASLG
3MP:00036317.7CD40LG, FAS, BCR, HLA-DQB1, FN1
4MP:00053767.4FAS, FASLG, HLA-DQB1, CD40LG, BCR, FN1
5MP:00053977.2FN1, BCR, CD40LG, CD5, HLA-DQB1, FASLG
6MP:00053877.1BCR, FAS, FASLG, HLA-DQB1, FN1, CD5
7MP:00053847.1BCR, FAS, FASLG, HLA-DQB1, FN1, CD5

Publications for Type Ii Mixed Cryoglobulinemia

About this section

Genetic Variations for Type Ii Mixed Cryoglobulinemia

About this section

Expression for genes affiliated with Type Ii Mixed Cryoglobulinemia

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Type Ii Mixed Cryoglobulinemia

Search GEO for disease gene expression data for Type Ii Mixed Cryoglobulinemia.

Pathways for genes affiliated with Type Ii Mixed Cryoglobulinemia

About this section
Sources:
29KEGG, 12EMD Millipore, 53Reactome, 37NCBI BioSystems Database, 52R&D Systems, 55SinoBiological, 51QIAGEN
See all sources

Pathways related to Type Ii Mixed Cryoglobulinemia according to GeneCards/GeneDecks:

(show all 18)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0FN1
29.5FN1, FASLG
3
Immune response Antigen presentation by MHC class II
Hide members
9.5HLA-DQB1, HLA-DRB1
4
Hide members
9.5HLA-DQB1, HLA-DRB1
59.4CD40LG, FN1
69.2FAS, FASLG
7
Hide members
9.2FAS, FASLG
8
Signal transduction JNK pathway
Hide members
9.2FASLG, FAS
9
Hide members
9.2FASLG, FAS
109.2FAS, FASLG
11
Hide members
9.2FASLG, FAS
12
Hide members
9.0CD40LG, HLA-DQB1, HLA-DRB1
139.0HLA-DQB1, HLA-DRB1, CD40LG
14
Hide members
9.0CD40LG, HLA-DRB1, HLA-DQB1
15
Hide members
8.3CD40LG, HLA-DQB1, FASLG, FAS
168.3FAS, FN1, BCR, FASLG
17
Hide members
8.2HLA-DRB1, FASLG, FAS, HLA-DQB1
18
Hide members
7.7CD40LG, HLA-DRB1, FAS, HLA-DQB1, FASLG

Compounds for genes affiliated with Type Ii Mixed Cryoglobulinemia

About this section
Sources:
44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 49PharmGKB, 24HMDB, 2BitterDB
See all sources

Compounds related to Type Ii Mixed Cryoglobulinemia according to GeneCards/GeneDecks:

(show top 50)    (show all 70)
idCompoundScoreTop Affiliating Genes
1gliadin4410.4CD40LG
2indomethacin44 59 28 1113.4FN1
3pge24410.3FN1
4phosphatidylserine44 28 1112.2FASLG
5aspartate449.9CD40LG, FASLG
6bosentan44 1110.9FASLG, FN1
7amoxicillin44 49 1111.9CD40LG, HLA-DQB1
8cyclosporin a44 28 5911.8FN1, CD40LG
9h2o2449.8BCR, FASLG
10blys449.8CD40LG, BCR
11bamhi449.6BCR, HLA-DQB1
12(glc)4449.6FAS, FASLG
13atpo44 2810.6FAS, FASLG
14fluorochrome449.6CD40LG, BCR
15rituximab44 49 1111.5FASLG, CD40LG, BCR
16pmma449.4CD40LG, FN1
17cytochalasin d44 5910.4FN1, FASLG, BCR
18teniposide44 1110.4FASLG, FAS
19biotin44 11 2411.4FASLG, FN1, CD40LG
20imatinib44 49 1111.3FN1, BCR, FASLG
21hyaluronic acid44 2410.3CD40LG, FASLG, FN1
222-chlorodeoxyadenosine449.2FASLG, CD40LG, FAS
23cytarabine44 49 1111.2FASLG, BCR, FAS
24fludarabine44 1110.2FAS, FASLG, CD40LG
25ivig449.1CD40LG, FAS, FASLG
26rottlerin449.1CD40LG, FASLG, FAS
27tetracycline44 1110.1FAS, CD40LG, FASLG
28adriamycin449.1FASLG, FAS, FN1
29tgf beta1449.0FN1, FAS, FASLG
30ceramide449.0FASLG, FAS, BCR
31ionomycin448.9FAS, FASLG, CD40LG
32herbimycin a44 599.9CD40LG, FAS, FN1
33pd 98,059448.7BCR, FN1, FASLG, FAS
34ly294002448.7FASLG, FN1, BCR, FAS
35agar448.6FAS, FASLG, FN1, CD40LG
36polysaccharide448.6FN1, CD40LG, FASLG, FAS
37thymidine44 249.6FASLG, FAS, BCR, FN1
38rapamycin448.6FAS, CD40LG, FN1, FASLG
39doxorubicin44 49 1110.6FASLG, FN1, FAS, CD40LG
40actinomycin d448.6FAS, FN1, FASLG, CD40LG
41lactate448.6FASLG, FAS, CD40LG, FN1
42cisplatin44 49 59 1111.6CD40LG, FN1, FASLG, FAS
43aspirin44 49 28 2411.5CD40LG, FN1, FAS
44paraffin448.3CD5, FAS, FASLG, FN1, CD40LG
45oligonucleotide448.2FAS, FASLG, HLA-DQB1, HLA-DRB1, BCR
46genistein44 28 59 2 11 2413.2BCR, CD40LG, FASLG, FN1, FAS
47heparin44 28 11 2411.2FAS, FASLG, FN1, CD40LG, BCR
48cysteine448.1BCR, FASLG, CD40LG, FN1, FAS
49dexamethasone44 49 28 1110.9FASLG, FAS, CD40LG, FN1
50tyrosine447.4HLA-DQB1, CD5, FN1, FASLG, FAS, HLA-DRB1

GO Terms for genes affiliated with Type Ii Mixed Cryoglobulinemia

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Type Ii Mixed Cryoglobulinemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class II protein complexGO:0426139.6HLA-DQB1, HLA-DRB1
2clathrin-coated endocytic vesicle membraneGO:0306699.6HLA-DQB1, HLA-DRB1
3integral to lumenal side of endoplasmic reticulum membraneGO:0715569.5HLA-DQB1, HLA-DRB1
4transport vesicle membraneGO:0306589.5HLA-DQB1, HLA-DRB1
5ER to Golgi transport vesicle membraneGO:0125079.4HLA-DQB1, HLA-DRB1
6trans-Golgi network membraneGO:0325889.2HLA-DQB1, HLA-DRB1
7external side of plasma membraneGO:0098977.9CD40LG, FAS, FASLG, CD5, HLA-DRB1
8plasma membraneGO:0058867.3HLA-DQB1, FAS, HLA-DRB1, CD5, CD40LG, BCR

Biological processes related to Type Ii Mixed Cryoglobulinemia according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1immunoglobulin production involved in immunoglobulin mediated immune responseGO:0023819.6HLA-DRB1, HLA-DQB1
2positive regulation of endothelial cell apoptotic processGO:20003539.5FASLG, CD40LG
3humoral immune response mediated by circulating immunoglobulinGO:0024559.5HLA-DQB1, HLA-DRB1
4inflammatory cell apoptotic processGO:0069259.4FASLG, FAS
5T cell costimulationGO:0312959.3HLA-DRB1, HLA-DQB1, CD5
6extrinsic apoptotic signaling pathway via death domain receptorsGO:0086259.2FAS, FASLG
7regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012398.9FASLG, FAS
8apoptotic signaling pathwayGO:0971908.8FASLG, CD5, FAS

Molecular functions related to Type Ii Mixed Cryoglobulinemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tumor necrosis factor receptor bindingGO:0051649.5CD40LG, FASLG
2MHC class II receptor activityGO:0323959.2HLA-DRB1, HLA-DQB1

Products for genes affiliated with Type Ii Mixed Cryoglobulinemia

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Type Ii Mixed Cryoglobulinemia

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet