MCID: TYP024
MIFTS: 47

Type Ii Mixed Cryoglobulinemia malady

Genetic diseases, Neuronal diseases, Cardiovascular diseases, Nephrological diseases, Respiratory diseases, Bone diseases, Rare diseases categories
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Summaries for Type Ii Mixed Cryoglobulinemia

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MalaCards based summary: Type Ii Mixed Cryoglobulinemia, also known as mc type ii, is related to cryoglobulinemia and hepatitis. An important gene associated with Type Ii Mixed Cryoglobulinemia is CD5 (CD5 molecule), and among its related pathways are Calcineurin-regulated NFAT-dependent transcription in lymphocytes and Immune response Role of integrins in NK cells cytotoxicity. The compounds amoxicillin and bosentan have been mentioned in the context of this disorder. Affiliated tissues include bone, b cells and lymph node, and related mouse phenotypes are normal and renal/urinary system.

Aliases & Classifications for Type Ii Mixed Cryoglobulinemia

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Sources:
48Orphanet, 26ICD10 via Orphanet
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Related Diseases for Type Ii Mixed Cryoglobulinemia

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Diseases in the Type Ii Mixed Cryoglobulinemia family:

Cryoglobulinemia, Familial Mixed Mixed Cryoglobulinemia Type Iii

Diseases related to Type Ii Mixed Cryoglobulinemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 76)
idRelated DiseaseScoreTop Affiliating Genes
1cryoglobulinemia32.1CD5, CD40LG
2hepatitis31.1FAS, FASLG, HLA-DRB1
3hepatitis c31.0CD40LG, HLA-DRB1, FAS
4vasculitis30.8CD40LG, FN1
5non-hodgkin lymphoma30.2FAS, CD5, HLA-DRB1
6hepatitis c virus10.8
7macroglobulinemia10.5CD5
8b-cell lymphomas10.4
9glomerulonephritis10.4
10narcolepsy10.3HLA-DRB1
11hiv-110.3
12hodgkin's lymphoma10.3
13liver disease10.3
14membranoproliferative glomerulonephritis10.3
15hepatitis e10.3
16proliferative glomerulonephritis10.3
17pyoderma gangrenosum10.3
18retinal vasculitis10.3
19cerebritis10.3
20neuropathy10.3
21pyoderma10.3
22retinitis10.3
23scleritis10.3
24indolent b cell lymphoma10.3
25lupus erythematosus10.3CD40LG
26cryoglobulinemic vasculitis10.3CD5, CD40LG
27immunoglobulin alpha deficiency10.3HLA-DQB1, CD40LG
28multiple sclerosis 110.2HLA-DQB1, HLA-DRB1
29leptospirosis10.2CD40LG, FN1
30juvenile rheumatoid arthritis10.2HLA-DQB1, HLA-DRB1
31pulmonary tuberculosis10.2HLA-DRB1, HLA-DQB1
32thyroiditis10.2HLA-DRB1, FASLG
33type 1 diabetes mellitus10.1FASLG, HLA-DRB1
34hepatitis b10.1HLA-DRB1, HLA-DQB1
35lupus nephritis10.1FN1, CD40LG
36skin disease10.1HLA-DRB1, FN1
37toxic epidermal necrolysis10.1FAS, FASLG
38silicosis10.1FASLG, FAS
39lymphomatoid papulosis10.1FASLG, FAS
40stevens-johnson syndrome10.1FASLG, FAS
41autoimmune lymphoproliferative syndrome10.1FASLG, FAS
42berger disease10.1CD40LG, FN1
43nephritis10.1CD40LG, FN1
44cutaneous t cell lymphoma10.0CD5, FAS
45aplastic anemia10.0FASLG, FAS
46lymphopenia10.0FASLG, FAS
47autoimmune thyroiditis10.0FAS, FASLG
48systemic scleroderma10.0CD40LG, HLA-DRB1, HLA-DQB1
49primary biliary cirrhosis10.0HLA-DRB1, CD40LG
50multiple sclerosis10.0FASLG, HLA-DQB1, HLA-DRB1

Graphical network of the top 20 diseases related to Type Ii Mixed Cryoglobulinemia:



Diseases related to type ii mixed cryoglobulinemia

Symptoms for Type Ii Mixed Cryoglobulinemia

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Drugs & Therapeutics for Type Ii Mixed Cryoglobulinemia

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Drug clinical trials:

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Search NIH Clinical Center for Type Ii Mixed Cryoglobulinemia

Genetic Tests for Type Ii Mixed Cryoglobulinemia

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Anatomical Context for Type Ii Mixed Cryoglobulinemia

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MalaCards organs/tissues related to Type Ii Mixed Cryoglobulinemia:

32
Bone, B cells, Lymph node, Bone marrow, Brain, Liver

Animal Models for Type Ii Mixed Cryoglobulinemia or affiliated genes

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Publications for Type Ii Mixed Cryoglobulinemia

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Articles related to Type Ii Mixed Cryoglobulinemia:

(show all 48)
idTitleAuthorsYear
1
Scleritis and retinal vasculitis associated with a type II mixed cryoglobulinemia. (24259719)
2013
2
HCV proteins and immunoglobulin variable gene (IgV) subfamilies in HCV-induced type II mixed cryoglobulinemia: a concurrent pathogenetic role. (22690241)
2012
3
Molecular signatures of hepatitis C virus (HCV)-induced type II mixed cryoglobulinemia (MCII). (23202510)
2012
4
Parvovirus B19-induced type II mixed cryoglobulinemia. (21854885)
2011
5
Clinical spectrum, treatment, and outcome of patients with type II mixed cryoglobulinemia without evidence of hepatitis C infection. (21239761)
2011
6
An experimental type II mixed cryoglobulinemia with renal glomerulopathy in ICR mice triggered by Capillaria hepatica infection. (21972091)
2011
7
HLA DR-DQ combination associated with the increased risk of developing human HCV positive non-Hodgkin's lymphoma is related to the type II mixed cryoglobulinemia. (20002609)
2010
8
Characterization of antibodies directed against the immunoglobulin light kappa chain variable chain region (VK) of hepatitis C virus-related type-II mixed cryoglobulinemia and B-cell proliferations. (19758144)
2009
9
Hepatitis C virus-associated type II mixed cryoglobulinemia vasculitis complicated with membranous proliferative glomerulonephritis. (19212913)
2009
10
Essential type II mixed cryoglobulinemia causing pyoderma gangrenosum-like ulcers. (18335149)
2008
11
Fibronectin gene polymorphisms are associated with the development of B-cell lymphoma in type II mixed cryoglobulinemia. (17526550)
2008
12
Efficacy and risk of rituximab in type II mixed cryoglobulinemia: a significant case report. (17936216)
2007
13
Genetic insights into the disease mechanisms of type II mixed cryoglobulinemia induced by hepatitis C virus. (17936227)
2007
14
The use of monoclonal antibody (rituximab) in the treatment of type II mixed cryoglobulinemia. (17625752)
2007
15
Paradoxical brain embolism associated with HCV-related type II mixed cryoglobulinemia. (17493820)
2007
16
HCV-related immunocytoma and type II mixed cryoglobulinemia-associated autoantigens. (17911427)
2007
17
HCV-NS3 and IgG-Fc crossreactive IgM in patients with type II mixed cryoglobulinemia and B-cell clonal proliferations. (16617326)
2006
18
Transfusion-associated TT virus co-infection in patients with hepatitis C virus is associated with type II mixed cryoglobulinemia but not with B-cell non-Hodgkin lymphoma. (12691541)
2003
19
Cerebral vasculitis in a patient with HCV-related type II mixed cryoglobulinemia. (12968400)
2003
20
Efficacy and safety of rituximab in type II mixed cryoglobulinemia. (12560225)
2003
21
Influence of age and autoimmunity on liver disease in HCV-associated type II mixed cryoglobulinemia. (12175729)
2002
22
Rituximab for the treatment of type II mixed cryoglobulinemia. (12209536)
2002
23
Severe cutaneous vasculitis following intravenous infusion of gammaglobulin in a patient with type II mixed cryoglobulinemia. (12051404)
2002
24
Characterization of cryoglobulin, M protein, low molecular weight IgM in a patient with chronic hepatitis C and type II mixed cryoglobulinemia]. (11769562)
2001
25
Membranoproliferative glomerulonephritis and demyelinating neuropathy caused by type II mixed cryoglobulinemia associated with HCV infection. (10830181)
2000
26
Oligoclonal non-neoplastic B cell expansion is the key feature of type II mixed cryoglobulinemia: clinical and molecular findings do not support a bone marrow pathologic diagnosis of indolent B cell lymphoma. (10643704)
2000
27
Peri-lesional injections of granulocyte-macrophage colony-stimulating factor in the management of chronic leg ulcers in type II mixed cryoglobulinemia. (10980654)
2000
28
Splenectomy may improve the glomerulopathy of type II mixed cryoglobulinemia. (10845834)
2000
29
Lack of Fas and Fas-L mutations in patients with lymphoproliferative disorders associated with SjAPgren's syndrome and type II mixed cryoglobulinemia. (10410268)
1999
30
Rituximab for the treatment of type II mixed cryoglobulinemia. (10586221)
1999
31
Failure of cyclosporin therapy in type II mixed cryoglobulinemia associated with hepatitis C virus infection. (9706447)
1998
32
Interferon for hepatitis C virus-negative type II mixed cryoglobulinemia. (9575053)
1998
33
Asymptomatic type II mixed cryoglobulinemia with a very high cryocrit level secondary to HCV infection. (9779567)
1998
34
GB virus C infection in patients with type II mixed cryoglobulinemia. (9382367)
1997
35
Detection and distribution of hepatitis C virus-related proteins in lymph nodes of patients with type II mixed cryoglobulinemia and neoplastic or non-neoplastic lymphoproliferation. (8977256)
1996
36
Hepatitis C virus genotype analysis in patients with type II mixed cryoglobulinemia. (7503475)
1996
37
Type II mixed cryoglobulinemia treated with fludarabine. (8730157)
1996
38
Lymph node angiogenesis in lymphoproliferative disorders: type II Mixed cryoglobulinemia as a model. (8730490)
1995
39
Hepatitis C virus within a malignant lymphoma lesion in the course of type II mixed cryoglobulinemia. (7655017)
1995
40
Disappearance of cryoglobulins and remission of symptoms in a patient with HCV-associated type II mixed cryoglobulinemia after HIV-1 infection. (8730498)
1995
41
A pilot study on the effectiveness of cyclosporine in type II mixed cryoglobulinemia. (8730507)
1995
42
Low prevalence of hepatitis E virus in type II mixed cryoglobulinemia. (8647527)
1995
43
HLA expression in type II mixed cryoglobulinemia and chronic hepatitis C virus. (8730485)
1995
44
Lymphoproliferation in type II mixed cryoglobulinemia. (8730495)
1995
45
Natural interferon-alpha versus its combination with 6-methyl-prednisolone in the therapy of type II mixed cryoglobulinemia: a long-term, randomized, controlled study. (7524736)
1994
46
Long-term effects of alpha-interferon therapy for type II mixed cryoglobulinemia. (7528704)
1994
47
High prevalence of hepatitis C virus RNA in the supernatant and the cryoprecipitate of patients with essential and secondary type II mixed cryoglobulinemia. (7525697)
1994
48
Hepatitis C virus infection in type II mixed cryoglobulinemia. (8216392)
1993

Variations for Type Ii Mixed Cryoglobulinemia

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Expression for genes affiliated with Type Ii Mixed Cryoglobulinemia

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Expression patterns in normal tissues for genes affiliated with Type Ii Mixed Cryoglobulinemia

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Pathways for genes affiliated with Type Ii Mixed Cryoglobulinemia

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Pathways related to Type Ii Mixed Cryoglobulinemia according to GeneCards/GeneDecks:

(show all 26)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Calcium signaling in the CD4+ TCR pathway37
9.5CD40LG, FASLG
29.5FASLG, FN1
39.5HLA-DRB1, CD5
4
Show member pathways
9.4HLA-DRB1, HLA-DQB1
5
Show member pathways
9.4HLA-DRB1, HLA-DQB1
69.4HLA-DRB1, HLA-DQB1
79.4HLA-DRB1, HLA-DQB1
8
Show member pathways
Immune response IL 22 signaling pathway60
G protein signaling N RAS regulation pathway60
9.4HLA-DRB1, HLA-DQB1
99.4CD40LG, FN1
10
Show member pathways
Immune response IL 12 induced IFN gamma production60
9.4FASLG, HLA-DRB1
11
Show member pathways
FAS pathway and Stress induction of HSP regulation37
Apoptosis and survival FAS signaling cascades60
Caspase cascade in apoptosis37
9.2FASLG, FAS
12
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
9.2FASLG, FAS
13
Show member pathways
TRAIL signaling pathway37
9.2FAS, FASLG
14
Show member pathways
Apoptosis and survival Apoptotic TNF family pathways60
9.2FASLG, FAS
159.2FASLG, FAS
16
Show member pathways
9.2FASLG, FAS
17
Show member pathways
9.2FASLG, FAS
189.2FASLG, FAS
198.9HLA-DQB1, HLA-DRB1, CD40LG
20
Show member pathways
8.9HLA-DQB1, HLA-DRB1, CD40LG
21
Show member pathways
8.9CD40LG, HLA-DRB1, HLA-DQB1
228.7FN1, FAS, FASLG
238.7FN1, FAS, FASLG
24
Show member pathways
8.3HLA-DQB1, FAS, FASLG, CD40LG
25
Show member pathways
8.2FASLG, FAS, HLA-DRB1, HLA-DQB1
26
Show member pathways
7.6CD40LG, FASLG, FAS, HLA-DRB1, HLA-DQB1

Compounds for genes affiliated with Type Ii Mixed Cryoglobulinemia

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Compounds related to Type Ii Mixed Cryoglobulinemia according to GeneCards/GeneDecks:

(show top 50)    (show all 81)
idCompoundScoreTop Affiliating Genes
1amoxicillin44 50 1111.9CD40LG, HLA-DQB1
2bosentan44 1110.9FASLG, FN1
3pmma449.6FN1, CD40LG
4(glc)4449.6FASLG, FAS
5atpo28 4410.6FAS, FASLG
6silicone449.5CD40LG, FN1
7teniposide44 1110.5FASLG, FAS
8biotin44 24 1111.4CD40LG, FASLG, FN1
9hyaluronic acid44 2410.3FN1, FASLG, CD40LG
10concanamycin a44 6110.2FASLG, FAS
11gliadin449.2CD40LG, FAS, HLA-DQB1
122-chlorodeoxyadenosine449.1FAS, FASLG, CD40LG
13fludarabine44 50 1111.1FAS, FASLG, CD40LG
14ivig449.1FAS, FASLG, CD40LG
15rottlerin449.1CD40LG, FASLG, FAS
16tetracycline44 1110.1CD40LG, FASLG, FAS
17adriamycin449.1FN1, FAS, FASLG
18tgf beta1449.1FASLG, FAS, FN1
19ionomycin449.0CD40LG, FASLG, FAS
20phosphatidylserine44 28 1111.0CD40LG, FASLG, FAS
21herbimycin a44 6110.0CD40LG, FAS, FN1
22rantes448.9FAS, FASLG, CD40LG
23aspirin44 50 28 2411.9CD40LG, FAS, FN1
24epinephrine44 24 1110.9CD40LG, FASLG, FAS
25n acetylcysteine448.9CD40LG, FASLG, FAS
26ascorbic acid44 249.8FAS, FASLG, CD40LG
27glutamate448.7HLA-DQB1, HLA-DRB1, FASLG, CD40LG
28sb 20358044 619.7FASLG, FAS, FN1
29aspartate448.7HLA-DQB1, FAS, FASLG, CD40LG
30alanine448.6CD40LG, FASLG, HLA-DRB1, FN1
31agar448.6CD40LG, FASLG, FAS, FN1
32indomethacin44 28 61 1111.6FN1, FAS, FASLG, CD40LG
33polysaccharide448.6CD40LG, FASLG, FAS, FN1
34rapamycin448.6CD40LG, FASLG, FAS, FN1
35doxorubicin44 50 1110.6FN1, FAS, FASLG, CD40LG
36actinomycin d448.6FN1, FAS, FASLG, CD40LG
37butyrate448.6FASLG, FAS, FN1
38genistein44 28 61 2 24 1113.6FN1, FAS, FASLG, CD40LG
39cyclosporin a44 28 6110.6FN1, FAS, FASLG, CD40LG
40lactate448.6FN1, FAS, FASLG, CD40LG
41cisplatin44 50 61 1111.6FN1, FAS, FASLG, CD40LG
42heparin44 28 24 1111.5FN1, FAS, FASLG, CD40LG
43oligonucleotide448.5HLA-DQB1, HLA-DRB1, FAS, FASLG
44dexamethasone44 50 28 1111.5FN1, FAS, FASLG, CD40LG
45vegf448.5FN1, FAS, FASLG, CD40LG
46arginine448.3FN1, HLA-DRB1, FAS, CD40LG
47paraffin448.2CD40LG, CD5, FASLG, FAS, FN1
48retinoic acid44 249.2FN1, FAS, FASLG, CD40LG
49cysteine447.9FN1, FAS, FASLG, CD40LG
50tyrosine447.7FN1, HLA-DQB1, HLA-DRB1, FAS, FASLG, CD5

GO Terms for genes affiliated with Type Ii Mixed Cryoglobulinemia

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Cellular components related to Type Ii Mixed Cryoglobulinemia according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1MHC class II protein complexGO:0426139.7HLA-DRB1, HLA-DQB1
2integral component of lumenal side of endoplasmic reticulum membraneGO:0715569.6HLA-DQB1, HLA-DRB1
3clathrin-coated endocytic vesicle membraneGO:0306699.6HLA-DRB1, HLA-DQB1
4transport vesicle membraneGO:0306589.6HLA-DQB1, HLA-DRB1
5ER to Golgi transport vesicle membraneGO:0125079.5HLA-DRB1, HLA-DQB1
6trans-Golgi network membraneGO:0325889.4HLA-DRB1, HLA-DQB1
7endocytic vesicle membraneGO:0306669.3HLA-DRB1, HLA-DQB1
8integral component of plasma membraneGO:0058878.7CD40LG, CD5, FASLG, HLA-DRB1
9external side of plasma membraneGO:0098977.9CD40LG, CD5, FASLG, FAS, HLA-DRB1
10extracellular vesicular exosomeGO:0700627.8FN1, HLA-DRB1, FAS, FASLG
11plasma membraneGO:0058867.7CD40LG, CD5, FAS, HLA-DRB1, HLA-DQB1

Biological processes related to Type Ii Mixed Cryoglobulinemia according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of endothelial cell apoptotic processGO:20003539.7CD40LG, FASLG
2immunoglobulin production involved in immunoglobulin mediated immune responseGO:0023819.7HLA-DQB1, HLA-DRB1
3humoral immune response mediated by circulating immunoglobulinGO:0024559.7HLA-DQB1, HLA-DRB1
4inflammatory cell apoptotic processGO:0069259.5FASLG, FAS
5necroptotic signaling pathwayGO:0975279.5FAS, FASLG
6interferon-gamma-mediated signaling pathwayGO:0603339.4HLA-DQB1, HLA-DRB1
7antigen processing and presentation of exogenous peptide antigen via MHC class IIGO:0198869.4HLA-DRB1, HLA-DQB1
8regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012399.4FAS, FASLG
9T cell costimulationGO:0312959.4CD5, HLA-DRB1, HLA-DQB1
10extrinsic apoptotic signaling pathway via death domain receptorsGO:0086259.3FASLG, FAS
11extrinsic apoptotic signaling pathwayGO:0971919.3FASLG, FAS
12T cell receptor signaling pathwayGO:0508529.1HLA-DRB1, HLA-DQB1
13activation of cysteine-type endopeptidase activity involved in apoptotic processGO:0069199.1FASLG, FAS
14apoptotic signaling pathwayGO:0971909.1CD5, FASLG, FAS
15immune responseGO:0069559.1FASLG, HLA-DRB1, HLA-DQB1

Molecular functions related to Type Ii Mixed Cryoglobulinemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tumor necrosis factor receptor bindingGO:0051649.5CD40LG, FASLG
2MHC class II receptor activityGO:0323959.1HLA-DRB1, HLA-DQB1

Products for genes affiliated with Type Ii Mixed Cryoglobulinemia

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Sources for Type Ii Mixed Cryoglobulinemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet