MCID: TYP024
MIFTS: 32

Type Ii Mixed Cryoglobulinemia malady

Genetic diseases, Neuronal diseases, Cardiovascular diseases, Nephrological diseases, Respiratory diseases, Bone diseases, Rare diseases categories

Aliases & Classifications for Type Ii Mixed Cryoglobulinemia

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Sources:
51Orphanet, 28ICD10 via Orphanet
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Summaries for Type Ii Mixed Cryoglobulinemia

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MalaCards based summary: Type Ii Mixed Cryoglobulinemia, also known as mc type ii, is related to cryoglobulinemia and hepatitis. An important gene associated with Type Ii Mixed Cryoglobulinemia is CD5 (CD5 Molecule), and among its related pathways are Staphylococcus aureus infection and CTLA4 Signaling. Affiliated tissues include bone, b cells and lymph node, and related mouse phenotypes are hematopoietic system and immune system.

Related Diseases for Type Ii Mixed Cryoglobulinemia

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Diseases in the Cryoglobulinemia, Familial Mixed family:

Mixed Cryoglobulinemia Type Iii type ii mixed cryoglobulinemia

Diseases related to Type Ii Mixed Cryoglobulinemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 74)
idRelated DiseaseScoreTop Affiliating Genes
1cryoglobulinemia11.1
2hepatitis10.9
3hepatitis c10.8
4hepatitis c virus10.8
5vasculitis10.6
6b-cell lymphomas10.4
7glomerulonephritis10.4
8hiv-110.3
9liver disease10.3
10membranoproliferative glomerulonephritis10.3
11retinal vasculitis10.3
12pyoderma gangrenosum10.3
13hepatitis e10.3
14cerebritis10.3
15proliferative glomerulonephritis10.3
16neuropathy10.3
17pyoderma10.3
18retinitis10.3
19scleritis10.3
20indolent b cell lymphoma10.3
21tucker syndrome10.1HLA-DQB1, HLA-DRB1
22testicular monophasic choriocarcinoma10.1HLA-DQB1, HLA-DRB1
23best1 retinopathy10.1HLA-DQB1, HLA-DRB1
24lichen planus pemphigoides10.1HLA-DQB1, HLA-DRB1
25microsomia hemifacial radial defects10.1HLA-DQB1, HLA-DRB1
26autoimmune polyglandular syndrome type 210.1HLA-DQB1, HLA-DRB1
27red cell phospholipid defect with hemolysis10.1HLA-DQB1, HLA-DRB1
28childhood cerebellar astrocytic neoplasm10.1HLA-DQB1, HLA-DRB1
29finnish upper limb-onset distal myopathy10.1HLA-DQB1, HLA-DRB1
30senile atrophy of choroid10.1HLA-DQB1, HLA-DRB1
31acute endometritis10.1HLA-DQB1, HLA-DRB1
32microsporidiosis10.1HLA-DQB1, HLA-DRB1
33oculogyric crisis10.1HLA-DQB1, HLA-DRB1
34moderately severe hemophilia a10.1HLA-DQB1, HLA-DRB1
35cytoplasmic body myopathy10.1HLA-DQB1, HLA-DRB1
36pulmonary nodular lymphoid hyperplasia10.1HLA-DQB1, HLA-DRB1
37ocular melanoma10.1HLA-DQB1, HLA-DRB1
38papillary adenocarcinoma10.1HLA-DQB1, HLA-DRB1
39hypertonia10.1HLA-DQB1, HLA-DRB1
40histidinemia10.1HLA-DQB1, HLA-DRB1
41limited scleroderma10.1HLA-DQB1, HLA-DRB1
42baritosis10.1HLA-DQB1, HLA-DRB1
43human spumaretrovirus infection10.1HLA-DQB1, HLA-DRB1
44ichthyosis - hypotrichosis - sclerosing cholangitis10.1HLA-DQB1, HLA-DRB1
45colorectal adenoma10.1FASLG, HLA-DRB1
46fungal gastritis10.1FAS, FASLG
47lymphomatous thyroiditis10.1FAS, FASLG
48cartilage-hair hypoplasia10.1FAS, FASLG
49small intestinal sarcoma10.1HLA-DQB1, HLA-DRB1
50acute orbital inflammation10.0FAS, FASLG

Graphical network of the top 20 diseases related to Type Ii Mixed Cryoglobulinemia:



Diseases related to type ii mixed cryoglobulinemia

Symptoms for Type Ii Mixed Cryoglobulinemia

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Drugs & Therapeutics for Type Ii Mixed Cryoglobulinemia

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Type Ii Mixed Cryoglobulinemia

Genetic Tests for Type Ii Mixed Cryoglobulinemia

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Anatomical Context for Type Ii Mixed Cryoglobulinemia

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MalaCards organs/tissues related to Type Ii Mixed Cryoglobulinemia:

33
Bone, B cells, Lymph node, Bone marrow, Liver, Brain

Animal Models for Type Ii Mixed Cryoglobulinemia or affiliated genes

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MGI Mouse Phenotypes related to Type Ii Mixed Cryoglobulinemia:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053977.6CD5, FAS, FASLG, FN1, HLA-DQB1
2MP:00053877.3CD5, FAS, FASLG, FN1, HLA-DQB1

Publications for Type Ii Mixed Cryoglobulinemia

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Articles related to Type Ii Mixed Cryoglobulinemia:

(show all 47)
idTitleAuthorsYear
1
Scleritis and retinal vasculitis associated with a type II mixed cryoglobulinemia. (24259719)
2013
2
HCV proteins and immunoglobulin variable gene (IgV) subfamilies in HCV-induced type II mixed cryoglobulinemia: a concurrent pathogenetic role. (22690241)
2012
3
Molecular signatures of hepatitis C virus (HCV)-induced type II mixed cryoglobulinemia (MCII). (23202510)
2012
4
Parvovirus B19-induced type II mixed cryoglobulinemia. (21854885)
2011
5
Clinical spectrum, treatment, and outcome of patients with type II mixed cryoglobulinemia without evidence of hepatitis C infection. (21239761)
2011
6
An experimental type II mixed cryoglobulinemia with renal glomerulopathy in ICR mice triggered by Capillaria hepatica infection. (21972091)
2011
7
HLA DR-DQ combination associated with the increased risk of developing human HCV positive non-Hodgkin's lymphoma is related to the type II mixed cryoglobulinemia. (20002609)
2010
8
Characterization of antibodies directed against the immunoglobulin light kappa chain variable chain region (VK) of hepatitis C virus-related type-II mixed cryoglobulinemia and B-cell proliferations. (19758144)
2009
9
Hepatitis C virus-associated type II mixed cryoglobulinemia vasculitis complicated with membranous proliferative glomerulonephritis. (19212913)
2009
10
Essential type II mixed cryoglobulinemia causing pyoderma gangrenosum-like ulcers. (18335149)
2008
11
Fibronectin gene polymorphisms are associated with the development of B-cell lymphoma in type II mixed cryoglobulinemia. (17526550)
2008
12
Efficacy and risk of rituximab in type II mixed cryoglobulinemia: a significant case report. (17936216)
2007
13
Genetic insights into the disease mechanisms of type II mixed cryoglobulinemia induced by hepatitis C virus. (17936227)
2007
14
The use of monoclonal antibody (rituximab) in the treatment of type II mixed cryoglobulinemia. (17625752)
2007
15
Paradoxical brain embolism associated with HCV-related type II mixed cryoglobulinemia. (17493820)
2007
16
HCV-related immunocytoma and type II mixed cryoglobulinemia-associated autoantigens. (17911427)
2007
17
HCV-NS3 and IgG-Fc crossreactive IgM in patients with type II mixed cryoglobulinemia and B-cell clonal proliferations. (16617326)
2006
18
Cerebral vasculitis in a patient with HCV-related type II mixed cryoglobulinemia. (12968400)
2003
19
Efficacy and safety of rituximab in type II mixed cryoglobulinemia. (12560225)
2003
20
Influence of age and autoimmunity on liver disease in HCV-associated type II mixed cryoglobulinemia. (12175729)
2002
21
Rituximab for the treatment of type II mixed cryoglobulinemia. (12209536)
2002
22
Severe cutaneous vasculitis following intravenous infusion of gammaglobulin in a patient with type II mixed cryoglobulinemia. (12051404)
2002
23
Characterization of cryoglobulin, M protein, low molecular weight IgM in a patient with chronic hepatitis C and type II mixed cryoglobulinemia]. (11769562)
2001
24
Membranoproliferative glomerulonephritis and demyelinating neuropathy caused by type II mixed cryoglobulinemia associated with HCV infection. (10830181)
2000
25
Oligoclonal non-neoplastic B cell expansion is the key feature of type II mixed cryoglobulinemia: clinical and molecular findings do not support a bone marrow pathologic diagnosis of indolent B cell lymphoma. (10643704)
2000
26
Peri-lesional injections of granulocyte-macrophage colony-stimulating factor in the management of chronic leg ulcers in type II mixed cryoglobulinemia. (10980654)
2000
27
Splenectomy may improve the glomerulopathy of type II mixed cryoglobulinemia. (10845834)
2000
28
Lack of Fas and Fas-L mutations in patients with lymphoproliferative disorders associated with SjAPgren's syndrome and type II mixed cryoglobulinemia. (10410268)
1999
29
Rituximab for the treatment of type II mixed cryoglobulinemia. (10586221)
1999
30
Failure of cyclosporin therapy in type II mixed cryoglobulinemia associated with hepatitis C virus infection. (9706447)
1998
31
Interferon for hepatitis C virus-negative type II mixed cryoglobulinemia. (9575053)
1998
32
Asymptomatic type II mixed cryoglobulinemia with a very high cryocrit level secondary to HCV infection. (9779567)
1998
33
GB virus C infection in patients with type II mixed cryoglobulinemia. (9382367)
1997
34
Detection and distribution of hepatitis C virus-related proteins in lymph nodes of patients with type II mixed cryoglobulinemia and neoplastic or non-neoplastic lymphoproliferation. (8977256)
1996
35
Hepatitis C virus genotype analysis in patients with type II mixed cryoglobulinemia. (7503475)
1996
36
Type II mixed cryoglobulinemia treated with fludarabine. (8730157)
1996
37
Lymph node angiogenesis in lymphoproliferative disorders: type II Mixed cryoglobulinemia as a model. (8730490)
1995
38
Hepatitis C virus within a malignant lymphoma lesion in the course of type II mixed cryoglobulinemia. (7655017)
1995
39
Disappearance of cryoglobulins and remission of symptoms in a patient with HCV-associated type II mixed cryoglobulinemia after HIV-1 infection. (8730498)
1995
40
A pilot study on the effectiveness of cyclosporine in type II mixed cryoglobulinemia. (8730507)
1995
41
Low prevalence of hepatitis E virus in type II mixed cryoglobulinemia. (8647527)
1995
42
HLA expression in type II mixed cryoglobulinemia and chronic hepatitis C virus. (8730485)
1995
43
Lymphoproliferation in type II mixed cryoglobulinemia. (8730495)
1995
44
Natural interferon-alpha versus its combination with 6-methyl-prednisolone in the therapy of type II mixed cryoglobulinemia: a long-term, randomized, controlled study. (7524736)
1994
45
Long-term effects of alpha-interferon therapy for type II mixed cryoglobulinemia. (7528704)
1994
46
High prevalence of hepatitis C virus RNA in the supernatant and the cryoprecipitate of patients with essential and secondary type II mixed cryoglobulinemia. (7525697)
1994
47
Hepatitis C virus infection in type II mixed cryoglobulinemia. (8216392)
1993

Variations for Type Ii Mixed Cryoglobulinemia

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Expression for genes affiliated with Type Ii Mixed Cryoglobulinemia

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Search GEO for disease gene expression data for Type Ii Mixed Cryoglobulinemia.

Pathways for genes affiliated with Type Ii Mixed Cryoglobulinemia

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Pathways related to Type Ii Mixed Cryoglobulinemia according to GeneCards Suite gene sharing:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5HLA-DQB1, HLA-DRB1
29.5HLA-DQB1, HLA-DRB1
39.3FAS, FASLG
49.3FAS, FASLG
5
Show member pathways
9.3FAS, FASLG
69.0FASLG, FN1
7
TNF Signaling (sino)
Show member pathways
8.9FASLG, FN1
88.5FAS, FASLG, FN1
98.5FAS, FASLG, FN1
10
Show member pathways
8.5FAS, FASLG, FN1
11
Show member pathways
8.4FAS, FASLG, HLA-DQB1, HLA-DRB1
12
Show member pathways
8.4FAS, FASLG, HLA-DQB1, HLA-DRB1

GO Terms for genes affiliated with Type Ii Mixed Cryoglobulinemia

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Cellular components related to Type Ii Mixed Cryoglobulinemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1MHC class II protein complexGO:004261310.0HLA-DQB1, HLA-DRB1
2integral component of lumenal side of endoplasmic reticulum membraneGO:007155610.0HLA-DQB1, HLA-DRB1
3ER to Golgi transport vesicle membraneGO:00125079.9HLA-DQB1, HLA-DRB1
4endocytic vesicle membraneGO:00306669.9HLA-DQB1, HLA-DRB1
5clathrin-coated endocytic vesicle membraneGO:00306699.8HLA-DQB1, HLA-DRB1
6trans-Golgi network membraneGO:00325889.8HLA-DQB1, HLA-DRB1
7transport vesicle membraneGO:00306589.5HLA-DQB1, HLA-DRB1
8external side of plasma membraneGO:00098978.7CD5, FAS, FASLG, HLA-DRB1
9integral component of plasma membraneGO:00058878.4CD5, FAS, FASLG, HLA-DRB1

Biological processes related to Type Ii Mixed Cryoglobulinemia according to GeneCards Suite gene sharing:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1antigen processing and presentation of peptide or polysaccharide antigen via MHC class IIGO:000250410.1HLA-DQB1, HLA-DRB1
2immunoglobulin production involved in immunoglobulin mediated immune responseGO:000238110.1HLA-DQB1, HLA-DRB1
3humoral immune response mediated by circulating immunoglobulinGO:000245510.0HLA-DQB1, HLA-DRB1
4interferon-gamma-mediated signaling pathwayGO:006033310.0HLA-DQB1, HLA-DRB1
5inflammatory cell apoptotic processGO:00069259.9FAS, FASLG
6necroptotic signaling pathwayGO:00975279.9FAS, FASLG
7activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathwayGO:00972969.9FAS, FASLG
8regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:19020419.9FAS, FASLG
9antigen processing and presentationGO:00198829.9HLA-DQB1, HLA-DRB1
10extrinsic apoptotic signaling pathwayGO:00971919.9FAS, FASLG
11regulation of necrotic cell deathGO:00109399.9FAS, FASLG
12necroptotic processGO:00702669.8FAS, FASLG
13programmed necrotic cell deathGO:00973009.8FAS, FASLG
14extrinsic apoptotic signaling pathway via death domain receptorsGO:00086259.8FAS, FASLG
15activation of cysteine-type endopeptidase activity involved in apoptotic processGO:00069199.5FAS, FASLG
16T cell costimulationGO:00312959.5CD5, HLA-DQB1, HLA-DRB1
17negative regulation of cysteine-type endopeptidase activity involved in apoptotic processGO:00431549.3FAS, FASLG
18apoptotic signaling pathwayGO:00971908.9CD5, FAS, FASLG
19immune responseGO:00069558.1FAS, FASLG, HLA-DQB1, HLA-DRB1

Molecular functions related to Type Ii Mixed Cryoglobulinemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1MHC class II receptor activityGO:00323959.7HLA-DQB1, HLA-DRB1
2peptide antigen bindingGO:00426059.5HLA-DQB1, HLA-DRB1

Sources for Type Ii Mixed Cryoglobulinemia

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet