MCID: TYP024
MIFTS: 32

Type Ii Mixed Cryoglobulinemia malady

Categories: Genetic diseases, Neuronal diseases, Cardiovascular diseases, Nephrological diseases, Respiratory diseases, Bone diseases, Rare diseases

Aliases & Classifications for Type Ii Mixed Cryoglobulinemia

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Sources:
51Orphanet, 28ICD10 via Orphanet
See all MalaCards sources

Summaries for Type Ii Mixed Cryoglobulinemia

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MalaCards based summary: Type Ii Mixed Cryoglobulinemia, also known as mc type ii, is related to cryoglobulinemia and hepatitis. An important gene associated with Type Ii Mixed Cryoglobulinemia is HLA-DQB1 (Major Histocompatibility Complex, Class II, DQ Beta 1), and among its related pathways are Immune response Antigen presentation by MHC class II and Phagosome. Affiliated tissues include bone, prostate and lung.

Related Diseases for Type Ii Mixed Cryoglobulinemia

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Diseases in the Familial Mixed Cryoglobulinemia family:

Mixed Cryoglobulinemia Type Iii type ii mixed cryoglobulinemia

Diseases related to Type Ii Mixed Cryoglobulinemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 61)
idRelated DiseaseScoreTop Affiliating Genes
1cryoglobulinemia10.7
2hepatitis10.5
3hepatitis c10.5
4hepatitis c virus10.4
5lymphoma10.2
6vasculitis10.2
7lichen planus pemphigoides10.1HLA-DQB1, HLA-DRB1
8tucker syndrome10.1HLA-DQB1, HLA-DRB1
9pulmonary coin lesion10.1HLA-DQB1, HLA-DRB1
10autoimmune polyglandular syndrome type 210.1HLA-DQB1, HLA-DRB1
11best1 retinopathy10.1HLA-DQB1, HLA-DRB1
12idiopathic juxtafoveal retinal telangiectasia10.1HLA-DQB1, HLA-DRB1
13non-distal monosomy 10q10.1HLA-DQB1, HLA-DRB1
14lichtenstein syndrome10.1HLA-DQB1, HLA-DRB1
15red cell phospholipid defect with hemolysis10.1HLA-DQB1, HLA-DRB1
16psoriasis10.1HLA-DQB1, HLA-DRB1
17actinomycosis10.1HLA-DQB1, HLA-DRB1
18finnish upper limb-onset distal myopathy10.1HLA-DQB1, HLA-DRB1
19metanephric adenoma10.1HLA-DQB1, HLA-DRB1
20nut allergy10.1HLA-DQB1, HLA-DRB1
21lymphocytic choriomeningitis10.1HLA-DQB1, HLA-DRB1
22moderately severe hemophilia a10.1HLA-DQB1, HLA-DRB1
23angioid streaks10.1HLA-DQB1, HLA-DRB1
24pulmonary nodular lymphoid hyperplasia10.1HLA-DQB1, HLA-DRB1
25cytoplasmic body myopathy10.1HLA-DQB1, HLA-DRB1
26hypersensitivity reaction type ii disease10.0FN1, HLA-DRB1
27hypertonia10.0HLA-DQB1, HLA-DRB1
28bipolar ll disorder10.0HLA-DQB1, HLA-DRB1
29b-cell lymphomas10.0
30glomerulonephritis10.0
31hepatoid adenocarcinoma10.0HLA-DQB1, HLA-DRB1
32bubonic plague10.0HLA-DQB1, HLA-DRB1
33kernicterus due to isoimmunization10.0HLA-DQB1, HLA-DRB1
34ichthyosis-hypotrichosis-sclerosing cholangitis syndrome10.0HLA-DQB1, HLA-DRB1
35byssinosis10.0HLA-DQB1, HLA-DRB1
36human spumaretrovirus infection10.0HLA-DQB1, HLA-DRB1
37artery disease9.9HLA-DQB1, HLA-DRB1
38rectal disease9.9HLA-DQB1, HLA-DRB1
39hiv-19.9
40hodgkin lymphoma9.9
41liver disease9.9
42retinal vasculitis9.9
43scleritis9.9
44membranoproliferative glomerulonephritis9.9
45cerebritis9.9
46retinitis9.9
47pyoderma9.9
48hepatitis e9.9
49proliferative glomerulonephritis9.9
50pyoderma gangrenosum9.9

Graphical network of the top 20 diseases related to Type Ii Mixed Cryoglobulinemia:



Diseases related to type ii mixed cryoglobulinemia

Symptoms for Type Ii Mixed Cryoglobulinemia

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Drugs & Therapeutics for Type Ii Mixed Cryoglobulinemia

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Type Ii Mixed Cryoglobulinemia

Genetic Tests for Type Ii Mixed Cryoglobulinemia

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Anatomical Context for Type Ii Mixed Cryoglobulinemia

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MalaCards organs/tissues related to Type Ii Mixed Cryoglobulinemia:

33
Bone, Prostate, Lung, B cells, Bone marrow, Liver, Endothelial

Animal Models for Type Ii Mixed Cryoglobulinemia or affiliated genes

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Publications for Type Ii Mixed Cryoglobulinemia

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Articles related to Type Ii Mixed Cryoglobulinemia:

(show all 49)
idTitleAuthorsYear
1
Scleritis and retinal vasculitis associated with a type II mixed cryoglobulinemia. (24259719)
2013
2
HCV proteins and immunoglobulin variable gene (IgV) subfamilies in HCV-induced type II mixed cryoglobulinemia: a concurrent pathogenetic role. (22690241)
2012
3
Molecular signatures of hepatitis C virus (HCV)-induced type II mixed cryoglobulinemia (MCII). (23202510)
2012
4
Parvovirus B19-induced type II mixed cryoglobulinemia. (21854885)
2011
5
Clinical spectrum, treatment, and outcome of patients with type II mixed cryoglobulinemia without evidence of hepatitis C infection. (21239761)
2011
6
An experimental type II mixed cryoglobulinemia with renal glomerulopathy in ICR mice triggered by Capillaria hepatica infection. (21972091)
2011
7
HLA DR-DQ combination associated with the increased risk of developing human HCV positive non-Hodgkin's lymphoma is related to the type II mixed cryoglobulinemia. (20002609)
2010
8
Characterization of antibodies directed against the immunoglobulin light kappa chain variable chain region (VK) of hepatitis C virus-related type-II mixed cryoglobulinemia and B-cell proliferations. (19758144)
2009
9
Hepatitis C virus-associated type II mixed cryoglobulinemia vasculitis complicated with membranous proliferative glomerulonephritis. (19212913)
2009
10
Essential type II mixed cryoglobulinemia causing pyoderma gangrenosum-like ulcers. (18335149)
2008
11
Fibronectin gene polymorphisms are associated with the development of B-cell lymphoma in type II mixed cryoglobulinemia. (17526550)
2008
12
Efficacy and risk of rituximab in type II mixed cryoglobulinemia: a significant case report. (17936216)
2007
13
Genetic insights into the disease mechanisms of type II mixed cryoglobulinemia induced by hepatitis C virus. (17936227)
2007
14
The use of monoclonal antibody (rituximab) in the treatment of type II mixed cryoglobulinemia. (17625752)
2007
15
Paradoxical brain embolism associated with HCV-related type II mixed cryoglobulinemia. (17493820)
2007
16
HCV-related immunocytoma and type II mixed cryoglobulinemia-associated autoantigens. (17911427)
2007
17
HCV-NS3 and IgG-Fc crossreactive IgM in patients with type II mixed cryoglobulinemia and B-cell clonal proliferations. (16617326)
2006
18
Transfusion-associated TT virus co-infection in patients with hepatitis C virus is associated with type II mixed cryoglobulinemia but not with B-cell non-Hodgkin lymphoma. (12691541)
2003
19
Cerebral vasculitis in a patient with HCV-related type II mixed cryoglobulinemia. (12968400)
2003
20
Efficacy and safety of rituximab in type II mixed cryoglobulinemia. (12560225)
2003
21
Influence of age and autoimmunity on liver disease in HCV-associated type II mixed cryoglobulinemia. (12175729)
2002
22
Rituximab for the treatment of type II mixed cryoglobulinemia. (12209536)
2002
23
Severe cutaneous vasculitis following intravenous infusion of gammaglobulin in a patient with type II mixed cryoglobulinemia. (12051404)
2002
24
Characterization of cryoglobulin, M protein, low molecular weight IgM in a patient with chronic hepatitis C and type II mixed cryoglobulinemia]. (11769562)
2001
25
Membranoproliferative glomerulonephritis and demyelinating neuropathy caused by type II mixed cryoglobulinemia associated with HCV infection. (10830181)
2000
26
Oligoclonal non-neoplastic B cell expansion is the key feature of type II mixed cryoglobulinemia: clinical and molecular findings do not support a bone marrow pathologic diagnosis of indolent B cell lymphoma. (10643704)
2000
27
Peri-lesional injections of granulocyte-macrophage colony-stimulating factor in the management of chronic leg ulcers in type II mixed cryoglobulinemia. (10980654)
2000
28
Splenectomy may improve the glomerulopathy of type II mixed cryoglobulinemia. (10845834)
2000
29
Lack of Fas and Fas-L mutations in patients with lymphoproliferative disorders associated with SjAPgren's syndrome and type II mixed cryoglobulinemia. (10410268)
1999
30
Rituximab for the treatment of type II mixed cryoglobulinemia. (10586221)
1999
31
Failure of cyclosporin therapy in type II mixed cryoglobulinemia associated with hepatitis C virus infection. (9706447)
1998
32
Interferon for hepatitis C virus-negative type II mixed cryoglobulinemia. (9575053)
1998
33
Asymptomatic type II mixed cryoglobulinemia with a very high cryocrit level secondary to HCV infection. (9779567)
1998
34
GB virus C infection in patients with type II mixed cryoglobulinemia. (9382367)
1997
35
Detection and distribution of hepatitis C virus-related proteins in lymph nodes of patients with type II mixed cryoglobulinemia and neoplastic or non-neoplastic lymphoproliferation. (8977256)
1996
36
Hepatitis C virus genotype analysis in patients with type II mixed cryoglobulinemia. (7503475)
1996
37
Type II mixed cryoglobulinemia treated with fludarabine. (8730157)
1996
38
Lymph node angiogenesis in lymphoproliferative disorders: type II Mixed cryoglobulinemia as a model. (8730490)
1995
39
Hepatitis C virus within a malignant lymphoma lesion in the course of type II mixed cryoglobulinemia. (7655017)
1995
40
Disappearance of cryoglobulins and remission of symptoms in a patient with HCV-associated type II mixed cryoglobulinemia after HIV-1 infection. (8730498)
1995
41
A pilot study on the effectiveness of cyclosporine in type II mixed cryoglobulinemia. (8730507)
1995
42
Low prevalence of hepatitis E virus in type II mixed cryoglobulinemia. (8647527)
1995
43
HLA expression in type II mixed cryoglobulinemia and chronic hepatitis C virus. (8730485)
1995
44
Lymphoproliferation in type II mixed cryoglobulinemia. (8730495)
1995
45
Natural interferon-alpha versus its combination with 6-methyl-prednisolone in the therapy of type II mixed cryoglobulinemia: a long-term, randomized, controlled study. (7524736)
1994
46
Long-term effects of alpha-interferon therapy for type II mixed cryoglobulinemia. (7528704)
1994
47
High prevalence of hepatitis C virus RNA in the supernatant and the cryoprecipitate of patients with essential and secondary type II mixed cryoglobulinemia. (7525697)
1994
48
Hepatitis C virus infection in type II mixed cryoglobulinemia. (8216392)
1993
49

Variations for Type Ii Mixed Cryoglobulinemia

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Expression for genes affiliated with Type Ii Mixed Cryoglobulinemia

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Search GEO for disease gene expression data for Type Ii Mixed Cryoglobulinemia.

Pathways for genes affiliated with Type Ii Mixed Cryoglobulinemia

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GO Terms for genes affiliated with Type Ii Mixed Cryoglobulinemia

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Cellular components related to Type Ii Mixed Cryoglobulinemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1ER to Golgi transport vesicle membraneGO:00125079.4HLA-DQB1, HLA-DRB1
2trans-Golgi network membraneGO:00325889.2HLA-DQB1, HLA-DRB1
3external side of plasma membraneGO:00098979.0CD5, HLA-DRB1

Biological processes related to Type Ii Mixed Cryoglobulinemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1immunoglobulin production involved in immunoglobulin mediated immune responseGO:00023819.3HLA-DQB1, HLA-DRB1
2antigen processing and presentationGO:00198829.3HLA-DQB1, HLA-DRB1

Sources for Type Ii Mixed Cryoglobulinemia

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet