MCID: TYP024
MIFTS: 33

Type Ii Mixed Cryoglobulinemia malady

Categories: Genetic diseases, Neuronal diseases, Cardiovascular diseases, Nephrological diseases, Respiratory diseases, Bone diseases, Rare diseases, Immune diseases

Aliases & Classifications for Type Ii Mixed Cryoglobulinemia

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Sources:
31ICD10 via Orphanet, 54Orphanet
See all MalaCards sources

Summaries for Type Ii Mixed Cryoglobulinemia

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MalaCards based summary: Type Ii Mixed Cryoglobulinemia, also known as mc type ii, is related to b-cell lymphomas and cryoglobulinemia. An important gene associated with Type Ii Mixed Cryoglobulinemia is HLA-DQB1 (Major Histocompatibility Complex, Class II, DQ Beta 1), and among its related pathways are CTLA4 Signaling and Staphylococcus aureus infection. Affiliated tissues include bone, b cells and lymph node, and related mouse phenotypes are liver/biliary system and normal.

Related Diseases for Type Ii Mixed Cryoglobulinemia

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Diseases in the Cryoglobulinemia, Familial Mixed family:

Mixed Cryoglobulinemia Type Iii type ii mixed cryoglobulinemia

Diseases related to Type Ii Mixed Cryoglobulinemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 68)
idRelated DiseaseScoreTop Affiliating Genes
1b-cell lymphomas29.8FAS, HLA-DQB1, HLA-DRB1
2cryoglobulinemia10.6
3hepatitis10.4
4hepatitis c10.3
5hepatitis c virus10.3
6apple allergy10.2HLA-DQB1, HLA-DRB1
7hemoglobin d disease10.2HLA-DQB1, HLA-DRB1
8bilateral parasagittal parieto-occipital polymicrogyria10.2HLA-DQB1, HLA-DRB1
9immune deficiency, familial variable10.2HLA-DQB1, HLA-DRB1
10lin-gettig syndrome10.2HLA-DQB1, HLA-DRB1
11autosomal dominant intermediate charcot-marie-tooth10.2HLA-DQB1, HLA-DRB1
12renal agenesis meningomyelocele mullerian defect10.2HLA-DQB1, HLA-DRB1
13lyme disease - neurological complications10.2HLA-DQB1, HLA-DRB1
14distal trisomy 14q10.2HLA-DQB1, HLA-DRB1
15learning disability10.2HLA-DQB1, HLA-DRB1
16linear lichen planus10.2HLA-DQB1, HLA-DRB1
17night blindness10.2HLA-DQB1, HLA-DRB1
18cervical adenoid basal carcinoma10.2HLA-DQB1, HLA-DRB1
19neonatal antiphospholipid syndrome10.2HLA-DQB1, HLA-DRB1
20clostridium difficile colitis10.2HLA-DQB1, HLA-DRB1
21t-cell prolymphocytic leukemia10.2FAS, HLA-DQB1
22myofibroma10.2HLA-DQB1, HLA-DRB1
23oromandibular dystonia10.2HLA-DQB1, HLA-DRB1
24non-amyloid monoclonal immunoglobulin deposition disease10.1FAS, HLA-DRB1
25cryptococcosis10.1HLA-DQB1, HLA-DRB1
26bickerstaff brainstem encephalitis10.1HLA-DQB1, HLA-DRB1
27anaerobic meningitis10.1HLA-DQB1, HLA-DRB1
28low anorectal malformation10.1HLA-DQB1, HLA-DRB1
29ragweed sensitivity10.1HLA-DQB1, HLA-DRB1
30skeletal muscle cancer10.1FAS, FASLG
31folinic acid-responsive seizures10.1HLA-DQB1, HLA-DRB1
32lymphoma10.1
33macrogyria, pseudobulbar palsy and mental retardation10.1FAS, FASLG
34anauxetic dysplasia10.1FAS, FASLG
35lymphangiectasia, intestinal10.1HLA-DQB1, HLA-DRB1
36trabecular follicular adenocarcinoma10.1FAS, FASLG
37mixed cell type cancer10.1FAS, FASLG
38pseudo-meigs syndrome10.1FAS, FASLG
39immunoglobulin g deficiency10.1FASLG, HLA-DRB1
40breast adenomyoepithelioma10.1FAS, FASLG
41choreatic disease10.1HLA-DQB1, HLA-DRB1
42vasculitis10.1
43parasitic helminthiasis infectious disease10.0HLA-DQB1, HLA-DRB1
44skin conditions10.0FAS, FASLG
45hyperaldosteronism, familial, type ii10.0CD5, FASLG
46anterior corneal pigmentation10.0FAS, HLA-DQB1, HLA-DRB1
47psoriasis susceptibility 110.0FAS, FASLG
48prostatic urethral cancer10.0FAS, FASLG
49hyperparathyroidism, neonatal9.9FAS, FASLG, HLA-DRB1
50baritosis9.9FAS, FASLG

Graphical network of the top 20 diseases related to Type Ii Mixed Cryoglobulinemia:



Diseases related to type ii mixed cryoglobulinemia

Symptoms & Phenotypes for Type Ii Mixed Cryoglobulinemia

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MGI Mouse Phenotypes related to Type Ii Mixed Cryoglobulinemia according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.9FAS, FASLG, FN1, HLA-DQB1
2MP:00028737.6CD5, FAS, FASLG, FN1, HLA-DQB1

Drugs & Therapeutics for Type Ii Mixed Cryoglobulinemia

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Type Ii Mixed Cryoglobulinemia

Genetic Tests for Type Ii Mixed Cryoglobulinemia

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Anatomical Context for Type Ii Mixed Cryoglobulinemia

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MalaCards organs/tissues related to Type Ii Mixed Cryoglobulinemia:

36
Bone, B cells, Lymph node, Bone marrow, Liver, Brain

Publications for Type Ii Mixed Cryoglobulinemia

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Articles related to Type Ii Mixed Cryoglobulinemia:

(show all 48)
idTitleAuthorsYear
1
Scleritis and retinal vasculitis associated with a type II mixed cryoglobulinemia. (24259719)
2013
2
HCV proteins and immunoglobulin variable gene (IgV) subfamilies in HCV-induced type II mixed cryoglobulinemia: a concurrent pathogenetic role. (22690241)
2012
3
Molecular signatures of hepatitis C virus (HCV)-induced type II mixed cryoglobulinemia (MCII). (23202510)
2012
4
Parvovirus B19-induced type II mixed cryoglobulinemia. (21854885)
2011
5
Clinical spectrum, treatment, and outcome of patients with type II mixed cryoglobulinemia without evidence of hepatitis C infection. (21239761)
2011
6
An experimental type II mixed cryoglobulinemia with renal glomerulopathy in ICR mice triggered by Capillaria hepatica infection. (21972091)
2011
7
HLA DR-DQ combination associated with the increased risk of developing human HCV positive non-Hodgkin's lymphoma is related to the type II mixed cryoglobulinemia. (20002609)
2010
8
Hepatitis C virus-associated type II mixed cryoglobulinemia vasculitis complicated with membranous proliferative glomerulonephritis. (19212913)
2009
9
Characterization of antibodies directed against the immunoglobulin light kappa chain variable chain region (VK) of hepatitis C virus-related type-II mixed cryoglobulinemia and B-cell proliferations. (19758144)
2009
10
Fibronectin gene polymorphisms are associated with the development of B-cell lymphoma in type II mixed cryoglobulinemia. (17526550)
2008
11
Essential type II mixed cryoglobulinemia causing pyoderma gangrenosum-like ulcers. (18335149)
2008
12
The use of monoclonal antibody (rituximab) in the treatment of type II mixed cryoglobulinemia. (17625752)
2007
13
Genetic insights into the disease mechanisms of type II mixed cryoglobulinemia induced by hepatitis C virus. (17936227)
2007
14
HCV-related immunocytoma and type II mixed cryoglobulinemia-associated autoantigens. (17911427)
2007
15
Paradoxical brain embolism associated with HCV-related type II mixed cryoglobulinemia. (17493820)
2007
16
Efficacy and risk of rituximab in type II mixed cryoglobulinemia: a significant case report. (17936216)
2007
17
HCV-NS3 and IgG-Fc crossreactive IgM in patients with type II mixed cryoglobulinemia and B-cell clonal proliferations. (16617326)
2006
18
Cerebral vasculitis in a patient with HCV-related type II mixed cryoglobulinemia. (12968400)
2003
19
Efficacy and safety of rituximab in type II mixed cryoglobulinemia. (12560225)
2003
20
Transfusion-associated TT virus co-infection in patients with hepatitis C virus is associated with type II mixed cryoglobulinemia but not with B-cell non-Hodgkin lymphoma. (12691541)
2003
21
Severe cutaneous vasculitis following intravenous infusion of gammaglobulin in a patient with type II mixed cryoglobulinemia. (12051404)
2002
22
Influence of age and autoimmunity on liver disease in HCV-associated type II mixed cryoglobulinemia. (12175729)
2002
23
Rituximab for the treatment of type II mixed cryoglobulinemia. (12209536)
2002
24
Characterization of cryoglobulin, M protein, low molecular weight IgM in a patient with chronic hepatitis C and type II mixed cryoglobulinemia]. (11769562)
2001
25
Membranoproliferative glomerulonephritis and demyelinating neuropathy caused by type II mixed cryoglobulinemia associated with HCV infection. (10830181)
2000
26
Splenectomy may improve the glomerulopathy of type II mixed cryoglobulinemia. (10845834)
2000
27
Oligoclonal non-neoplastic B cell expansion is the key feature of type II mixed cryoglobulinemia: clinical and molecular findings do not support a bone marrow pathologic diagnosis of indolent B cell lymphoma. (10643704)
2000
28
Peri-lesional injections of granulocyte-macrophage colony-stimulating factor in the management of chronic leg ulcers in type II mixed cryoglobulinemia. (10980654)
2000
29
Lack of Fas and Fas-L mutations in patients with lymphoproliferative disorders associated with SjAPgren's syndrome and type II mixed cryoglobulinemia. (10410268)
1999
30
Rituximab for the treatment of type II mixed cryoglobulinemia. (10586221)
1999
31
Asymptomatic type II mixed cryoglobulinemia with a very high cryocrit level secondary to HCV infection. (9779567)
1998
32
Interferon for hepatitis C virus-negative type II mixed cryoglobulinemia. (9575053)
1998
33
Failure of cyclosporin therapy in type II mixed cryoglobulinemia associated with hepatitis C virus infection. (9706447)
1998
34
GB virus C infection in patients with type II mixed cryoglobulinemia. (9382367)
1997
35
Detection and distribution of hepatitis C virus-related proteins in lymph nodes of patients with type II mixed cryoglobulinemia and neoplastic or non-neoplastic lymphoproliferation. (8977256)
1996
36
Hepatitis C virus genotype analysis in patients with type II mixed cryoglobulinemia. (7503475)
1996
37
Type II mixed cryoglobulinemia treated with fludarabine. (8730157)
1996
38
Lymph node angiogenesis in lymphoproliferative disorders: type II Mixed cryoglobulinemia as a model. (8730490)
1995
39
HLA expression in type II mixed cryoglobulinemia and chronic hepatitis C virus. (8730485)
1995
40
Hepatitis C virus within a malignant lymphoma lesion in the course of type II mixed cryoglobulinemia. (7655017)
1995
41
Lymphoproliferation in type II mixed cryoglobulinemia. (8730495)
1995
42
A pilot study on the effectiveness of cyclosporine in type II mixed cryoglobulinemia. (8730507)
1995
43
Disappearance of cryoglobulins and remission of symptoms in a patient with HCV-associated type II mixed cryoglobulinemia after HIV-1 infection. (8730498)
1995
44
Low prevalence of hepatitis E virus in type II mixed cryoglobulinemia. (8647527)
1995
45
Natural interferon-alpha versus its combination with 6-methyl-prednisolone in the therapy of type II mixed cryoglobulinemia: a long-term, randomized, controlled study. (7524736)
1994
46
High prevalence of hepatitis C virus RNA in the supernatant and the cryoprecipitate of patients with essential and secondary type II mixed cryoglobulinemia. (7525697)
1994
47
Long-term effects of alpha-interferon therapy for type II mixed cryoglobulinemia. (7528704)
1994
48
Hepatitis C virus infection in type II mixed cryoglobulinemia. (8216392)
1993

Variations for Type Ii Mixed Cryoglobulinemia

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Expression for genes affiliated with Type Ii Mixed Cryoglobulinemia

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Search GEO for disease gene expression data for Type Ii Mixed Cryoglobulinemia.

Pathways for genes affiliated with Type Ii Mixed Cryoglobulinemia

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Pathways related to Type Ii Mixed Cryoglobulinemia according to GeneCards Suite gene sharing:

(show all 18)
idSuper pathwaysScoreTop Affiliating Genes
19.6HLA-DQB1, HLA-DRB1
29.6HLA-DQB1, HLA-DRB1
39.4FAS, FASLG
4
Show member pathways
9.4FAS, FASLG
5
Show member pathways
9.4FAS, FASLG
69.4FAS, FASLG
79.4FAS, FASLG
89.4FAS, FASLG
9
Show member pathways
9.4FAS, FASLG
109.1FASLG, FN1
119.0CD5, HLA-DQB1, HLA-DRB1
128.6FAS, FASLG, FN1
13
Show member pathways
8.6FAS, FASLG, FN1
148.6FAS, FASLG, FN1
15
Show member pathways
8.6FAS, FASLG, FN1
16
Show member pathways
8.6FAS, FASLG, HLA-DQB1, HLA-DRB1
17
Show member pathways
8.6FAS, FASLG, HLA-DQB1, HLA-DRB1
18
Show member pathways
8.3FASLG, FN1, HLA-DQB1, HLA-DRB1

GO Terms for genes affiliated with Type Ii Mixed Cryoglobulinemia

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Cellular components related to Type Ii Mixed Cryoglobulinemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1clathrin-coated endocytic vesicle membraneGO:003066910.3HLA-DQB1, HLA-DRB1
2endocytic vesicle membraneGO:003066610.3HLA-DQB1, HLA-DRB1
3ER to Golgi transport vesicle membraneGO:001250710.3HLA-DQB1, HLA-DRB1
4integral component of lumenal side of endoplasmic reticulum membraneGO:007155610.2HLA-DQB1, HLA-DRB1
5MHC class II protein complexGO:004261310.2HLA-DQB1, HLA-DRB1
6trans-Golgi network membraneGO:003258810.1HLA-DQB1, HLA-DRB1
7transport vesicle membraneGO:00306589.6HLA-DQB1, HLA-DRB1
8external side of plasma membraneGO:00098978.9CD5, FAS, FASLG, HLA-DRB1

Biological processes related to Type Ii Mixed Cryoglobulinemia according to GeneCards Suite gene sharing:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1antigen processing and presentationGO:001988210.3HLA-DQB1, HLA-DRB1
2antigen processing and presentation of peptide or polysaccharide antigen via MHC class IIGO:000250410.3HLA-DQB1, HLA-DRB1
3humoral immune response mediated by circulating immunoglobulinGO:000245510.3HLA-DQB1, HLA-DRB1
4immunoglobulin production involved in immunoglobulin mediated immune responseGO:000238110.2HLA-DQB1, HLA-DRB1
5interferon-gamma-mediated signaling pathwayGO:006033310.2HLA-DQB1, HLA-DRB1
6activation of cysteine-type endopeptidase activity involved in apoptotic processGO:000691910.1FAS, FASLG
7activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathwayGO:009729610.1FAS, FASLG
8extrinsic apoptotic signaling pathwayGO:009719110.1FAS, FASLG
9extrinsic apoptotic signaling pathway via death domain receptorsGO:000862510.1FAS, FASLG
10inflammatory cell apoptotic processGO:000692510.0FAS, FASLG
11necroptotic signaling pathwayGO:009752710.0FAS, FASLG
12negative regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:190204210.0FAS, FASLG
13regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:19020419.9FAS, FASLG
14apoptotic signaling pathwayGO:00971909.5CD5, FAS, FASLG
15immune responseGO:00069559.2FAS, FASLG, HLA-DQB1, HLA-DRB1
16T cell costimulationGO:00312959.0CD5, HLA-DQB1, HLA-DRB1

Molecular functions related to Type Ii Mixed Cryoglobulinemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1MHC class II receptor activityGO:003239510.0HLA-DQB1, HLA-DRB1
2peptide antigen bindingGO:00426059.6HLA-DQB1, HLA-DRB1

Sources for Type Ii Mixed Cryoglobulinemia

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet