MCID: TYP024
MIFTS: 33

Type Ii Mixed Cryoglobulinemia malady

Categories: Neuronal diseases, Cardiovascular diseases, Nephrological diseases, Respiratory diseases, Bone diseases, Rare diseases, Immune diseases, Genetic diseases

Aliases & Classifications for Type Ii Mixed Cryoglobulinemia

Summaries for Type Ii Mixed Cryoglobulinemia

MalaCards based summary : Type Ii Mixed Cryoglobulinemia, also known as mc type ii, is related to b-cell lymphomas and cryoglobulinemia. An important gene associated with Type Ii Mixed Cryoglobulinemia is HLA-DQB1 (Major Histocompatibility Complex, Class II, DQ Beta 1), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Pathways in cancer. Affiliated tissues include bone, b cells and lymph node, and related phenotypes are liver/biliary system and normal

Related Diseases for Type Ii Mixed Cryoglobulinemia

Diseases in the Cryoglobulinemia, Familial Mixed family:

Mixed Cryoglobulinemia Type Iii Type Ii Mixed Cryoglobulinemia

Diseases related to Type Ii Mixed Cryoglobulinemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 68)
id Related Disease Score Top Affiliating Genes
1 b-cell lymphomas 29.8 FAS HLA-DQB1 HLA-DRB1
2 cryoglobulinemia 10.6
3 hepatitis 10.4
4 hepatitis c 10.3
5 hepatitis c virus 10.3
6 apple allergy 10.2 HLA-DQB1 HLA-DRB1
7 hemoglobin d disease 10.2 HLA-DQB1 HLA-DRB1
8 bilateral parasagittal parieto-occipital polymicrogyria 10.2 HLA-DQB1 HLA-DRB1
9 immune deficiency, familial variable 10.2 HLA-DQB1 HLA-DRB1
10 lin-gettig syndrome 10.2 HLA-DQB1 HLA-DRB1
11 autosomal dominant intermediate charcot-marie-tooth 10.2 HLA-DQB1 HLA-DRB1
12 renal agenesis meningomyelocele mullerian defect 10.2 HLA-DQB1 HLA-DRB1
13 lyme disease - neurological complications 10.2 HLA-DQB1 HLA-DRB1
14 distal trisomy 14q 10.2 HLA-DQB1 HLA-DRB1
15 learning disability 10.2 HLA-DQB1 HLA-DRB1
16 linear lichen planus 10.2 HLA-DQB1 HLA-DRB1
17 night blindness 10.2 HLA-DQB1 HLA-DRB1
18 cervical adenoid basal carcinoma 10.2 HLA-DQB1 HLA-DRB1
19 neonatal antiphospholipid syndrome 10.2 HLA-DQB1 HLA-DRB1
20 clostridium difficile colitis 10.2 HLA-DQB1 HLA-DRB1
21 t-cell prolymphocytic leukemia 10.2 FAS HLA-DQB1
22 myofibroma 10.2 HLA-DQB1 HLA-DRB1
23 oromandibular dystonia 10.2 HLA-DQB1 HLA-DRB1
24 non-amyloid monoclonal immunoglobulin deposition disease 10.1 FAS HLA-DRB1
25 cryptococcosis 10.1 HLA-DQB1 HLA-DRB1
26 bickerstaff brainstem encephalitis 10.1 HLA-DQB1 HLA-DRB1
27 anaerobic meningitis 10.1 HLA-DQB1 HLA-DRB1
28 low anorectal malformation 10.1 HLA-DQB1 HLA-DRB1
29 ragweed sensitivity 10.1 HLA-DQB1 HLA-DRB1
30 skeletal muscle cancer 10.1 FAS FASLG
31 folinic acid-responsive seizures 10.1 HLA-DQB1 HLA-DRB1
32 lymphoma 10.1
33 macrogyria, pseudobulbar palsy and mental retardation 10.1 FAS FASLG
34 anauxetic dysplasia 10.1 FAS FASLG
35 lymphangiectasia, intestinal 10.1 HLA-DQB1 HLA-DRB1
36 trabecular follicular adenocarcinoma 10.1 FAS FASLG
37 mixed cell type cancer 10.1 FAS FASLG
38 pseudo-meigs syndrome 10.1 FAS FASLG
39 immunoglobulin g deficiency 10.1 FASLG HLA-DRB1
40 breast adenomyoepithelioma 10.1 FAS FASLG
41 choreatic disease 10.1 HLA-DQB1 HLA-DRB1
42 vasculitis 10.1
43 parasitic helminthiasis infectious disease 10.0 HLA-DQB1 HLA-DRB1
44 skin conditions 10.0 FAS FASLG
45 hyperaldosteronism, familial, type ii 10.0 CD5 FASLG
46 anterior corneal pigmentation 10.0 FAS HLA-DQB1 HLA-DRB1
47 psoriasis susceptibility 1 10.0 FAS FASLG
48 prostatic urethral cancer 10.0 FAS FASLG
49 hyperparathyroidism, neonatal 9.9 FAS FASLG HLA-DRB1
50 baritosis 9.9 FAS FASLG

Graphical network of the top 20 diseases related to Type Ii Mixed Cryoglobulinemia:



Diseases related to Type Ii Mixed Cryoglobulinemia

Symptoms & Phenotypes for Type Ii Mixed Cryoglobulinemia

MGI Mouse Phenotypes related to Type Ii Mixed Cryoglobulinemia:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 liver/biliary system MP:0005370 9.26 FAS FASLG FN1 HLA-DQB1
2 normal MP:0002873 9.02 CD5 FAS FASLG FN1 HLA-DQB1

Drugs & Therapeutics for Type Ii Mixed Cryoglobulinemia

Search Clinical Trials , NIH Clinical Center for Type Ii Mixed Cryoglobulinemia

Genetic Tests for Type Ii Mixed Cryoglobulinemia

Anatomical Context for Type Ii Mixed Cryoglobulinemia

MalaCards organs/tissues related to Type Ii Mixed Cryoglobulinemia:

39
Bone, B Cells, Lymph Node, Bone Marrow, Liver, Brain

Publications for Type Ii Mixed Cryoglobulinemia

Articles related to Type Ii Mixed Cryoglobulinemia:

(show all 48)
id Title Authors Year
1
Scleritis and retinal vasculitis associated with a type II mixed cryoglobulinemia. ( 24259719 )
2013
2
HCV proteins and immunoglobulin variable gene (IgV) subfamilies in HCV-induced type II mixed cryoglobulinemia: a concurrent pathogenetic role. ( 22690241 )
2012
3
Molecular signatures of hepatitis C virus (HCV)-induced type II mixed cryoglobulinemia (MCII). ( 23202510 )
2012
4
Parvovirus B19-induced type II mixed cryoglobulinemia. ( 21854885 )
2011
5
Clinical spectrum, treatment, and outcome of patients with type II mixed cryoglobulinemia without evidence of hepatitis C infection. ( 21239761 )
2011
6
An experimental type II mixed cryoglobulinemia with renal glomerulopathy in ICR mice triggered by Capillaria hepatica infection. ( 21972091 )
2011
7
HLA DR-DQ combination associated with the increased risk of developing human HCV positive non-Hodgkin's lymphoma is related to the type II mixed cryoglobulinemia. ( 20002609 )
2010
8
Hepatitis C virus-associated type II mixed cryoglobulinemia vasculitis complicated with membranous proliferative glomerulonephritis. ( 19212913 )
2009
9
Characterization of antibodies directed against the immunoglobulin light kappa chain variable chain region (VK) of hepatitis C virus-related type-II mixed cryoglobulinemia and B-cell proliferations. ( 19758144 )
2009
10
Fibronectin gene polymorphisms are associated with the development of B-cell lymphoma in type II mixed cryoglobulinemia. ( 17526550 )
2008
11
Essential type II mixed cryoglobulinemia causing pyoderma gangrenosum-like ulcers. ( 18335149 )
2008
12
The use of monoclonal antibody (rituximab) in the treatment of type II mixed cryoglobulinemia. ( 17625752 )
2007
13
Genetic insights into the disease mechanisms of type II mixed cryoglobulinemia induced by hepatitis C virus. ( 17936227 )
2007
14
HCV-related immunocytoma and type II mixed cryoglobulinemia-associated autoantigens. ( 17911427 )
2007
15
Paradoxical brain embolism associated with HCV-related type II mixed cryoglobulinemia. ( 17493820 )
2007
16
Efficacy and risk of rituximab in type II mixed cryoglobulinemia: a significant case report. ( 17936216 )
2007
17
HCV-NS3 and IgG-Fc crossreactive IgM in patients with type II mixed cryoglobulinemia and B-cell clonal proliferations. ( 16617326 )
2006
18
Cerebral vasculitis in a patient with HCV-related type II mixed cryoglobulinemia. ( 12968400 )
2003
19
Efficacy and safety of rituximab in type II mixed cryoglobulinemia. ( 12560225 )
2003
20
Transfusion-associated TT virus co-infection in patients with hepatitis C virus is associated with type II mixed cryoglobulinemia but not with B-cell non-Hodgkin lymphoma. ( 12691541 )
2003
21
Severe cutaneous vasculitis following intravenous infusion of gammaglobulin in a patient with type II mixed cryoglobulinemia. ( 12051404 )
2002
22
Influence of age and autoimmunity on liver disease in HCV-associated type II mixed cryoglobulinemia. ( 12175729 )
2002
23
Rituximab for the treatment of type II mixed cryoglobulinemia. ( 12209536 )
2002
24
[Characterization of cryoglobulin, M protein, low molecular weight IgM in a patient with chronic hepatitis C and type II mixed cryoglobulinemia]. ( 11769562 )
2001
25
Membranoproliferative glomerulonephritis and demyelinating neuropathy caused by type II mixed cryoglobulinemia associated with HCV infection. ( 10830181 )
2000
26
Splenectomy may improve the glomerulopathy of type II mixed cryoglobulinemia. ( 10845834 )
2000
27
Oligoclonal non-neoplastic B cell expansion is the key feature of type II mixed cryoglobulinemia: clinical and molecular findings do not support a bone marrow pathologic diagnosis of indolent B cell lymphoma. ( 10643704 )
2000
28
Peri-lesional injections of granulocyte-macrophage colony-stimulating factor in the management of chronic leg ulcers in type II mixed cryoglobulinemia. ( 10980654 )
2000
29
Lack of Fas and Fas-L mutations in patients with lymphoproliferative disorders associated with SjAPgren's syndrome and type II mixed cryoglobulinemia. ( 10410268 )
1999
30
Rituximab for the treatment of type II mixed cryoglobulinemia. ( 10586221 )
1999
31
Asymptomatic type II mixed cryoglobulinemia with a very high cryocrit level secondary to HCV infection. ( 9779567 )
1998
32
Interferon for hepatitis C virus-negative type II mixed cryoglobulinemia. ( 9575053 )
1998
33
Failure of cyclosporin therapy in type II mixed cryoglobulinemia associated with hepatitis C virus infection. ( 9706447 )
1998
34
GB virus C infection in patients with type II mixed cryoglobulinemia. ( 9382367 )
1997
35
Detection and distribution of hepatitis C virus-related proteins in lymph nodes of patients with type II mixed cryoglobulinemia and neoplastic or non-neoplastic lymphoproliferation. ( 8977256 )
1996
36
Hepatitis C virus genotype analysis in patients with type II mixed cryoglobulinemia. ( 7503475 )
1996
37
Type II mixed cryoglobulinemia treated with fludarabine. ( 8730157 )
1996
38
Lymph node angiogenesis in lymphoproliferative disorders: type II Mixed cryoglobulinemia as a model. ( 8730490 )
1995
39
HLA expression in type II mixed cryoglobulinemia and chronic hepatitis C virus. ( 8730485 )
1995
40
Hepatitis C virus within a malignant lymphoma lesion in the course of type II mixed cryoglobulinemia. ( 7655017 )
1995
41
Lymphoproliferation in type II mixed cryoglobulinemia. ( 8730495 )
1995
42
A pilot study on the effectiveness of cyclosporine in type II mixed cryoglobulinemia. ( 8730507 )
1995
43
Disappearance of cryoglobulins and remission of symptoms in a patient with HCV-associated type II mixed cryoglobulinemia after HIV-1 infection. ( 8730498 )
1995
44
Low prevalence of hepatitis E virus in type II mixed cryoglobulinemia. ( 8647527 )
1995
45
Natural interferon-alpha versus its combination with 6-methyl-prednisolone in the therapy of type II mixed cryoglobulinemia: a long-term, randomized, controlled study. ( 7524736 )
1994
46
High prevalence of hepatitis C virus RNA in the supernatant and the cryoprecipitate of patients with essential and secondary type II mixed cryoglobulinemia. ( 7525697 )
1994
47
Long-term effects of alpha-interferon therapy for type II mixed cryoglobulinemia. ( 7528704 )
1994
48
Hepatitis C virus infection in type II mixed cryoglobulinemia. ( 8216392 )
1993

Variations for Type Ii Mixed Cryoglobulinemia

Expression for Type Ii Mixed Cryoglobulinemia

Search GEO for disease gene expression data for Type Ii Mixed Cryoglobulinemia.

Pathways for Type Ii Mixed Cryoglobulinemia

Pathways related to Type Ii Mixed Cryoglobulinemia according to GeneCards Suite gene sharing:

(show all 18)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.94 FASLG FN1 HLA-DQB1 HLA-DRB1
2 12.28 FAS FASLG FN1
3
Show member pathways
12.24 FAS FASLG FN1
4
Show member pathways
12.2 FAS FASLG HLA-DQB1 HLA-DRB1
5
Show member pathways
11.95 FAS FASLG HLA-DQB1 HLA-DRB1
6 11.81 FAS FASLG FN1
7
Show member pathways
11.65 FAS FASLG FN1
8
Show member pathways
11.51 FAS FASLG
9
Show member pathways
11.49 FAS FASLG
10 11.42 FAS FASLG
11 11.4 HLA-DQB1 HLA-DRB1
12 11.24 HLA-DQB1 HLA-DRB1
13 11.18 FAS FASLG
14 11.1 FASLG FN1
15 11.08 FAS FASLG
16
Show member pathways
11.01 FAS FASLG
17 10.91 FAS FASLG
18 10.79 CD5 HLA-DQB1 HLA-DRB1

GO Terms for Type Ii Mixed Cryoglobulinemia

Cellular components related to Type Ii Mixed Cryoglobulinemia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 trans-Golgi network membrane GO:0032588 9.43 HLA-DQB1 HLA-DRB1
2 endocytic vesicle membrane GO:0030666 9.4 HLA-DQB1 HLA-DRB1
3 ER to Golgi transport vesicle membrane GO:0012507 9.37 HLA-DQB1 HLA-DRB1
4 transport vesicle membrane GO:0030658 9.32 HLA-DQB1 HLA-DRB1
5 clathrin-coated endocytic vesicle membrane GO:0030669 9.26 HLA-DQB1 HLA-DRB1
6 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.16 HLA-DQB1 HLA-DRB1
7 MHC class II protein complex GO:0042613 8.96 HLA-DQB1 HLA-DRB1
8 external side of plasma membrane GO:0009897 8.92 CD5 FAS FASLG HLA-DRB1

Biological processes related to Type Ii Mixed Cryoglobulinemia according to GeneCards Suite gene sharing:

(show all 16)
id Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.71 FAS FASLG HLA-DQB1 HLA-DRB1
2 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.56 FAS FASLG
3 interferon-gamma-mediated signaling pathway GO:0060333 9.55 HLA-DQB1 HLA-DRB1
4 antigen processing and presentation GO:0019882 9.54 HLA-DQB1 HLA-DRB1
5 extrinsic apoptotic signaling pathway GO:0097191 9.52 FAS FASLG
6 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.51 FAS FASLG
7 T cell costimulation GO:0031295 9.5 CD5 HLA-DQB1 HLA-DRB1
8 extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 9.49 FAS FASLG
9 regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902041 9.48 FAS FASLG
10 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.46 HLA-DQB1 HLA-DRB1
11 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway GO:0097296 9.43 FAS FASLG
12 necroptotic signaling pathway GO:0097527 9.37 FAS FASLG
13 apoptotic signaling pathway GO:0097190 9.33 CD5 FAS FASLG
14 humoral immune response mediated by circulating immunoglobulin GO:0002455 9.26 HLA-DQB1 HLA-DRB1
15 inflammatory cell apoptotic process GO:0006925 8.96 FAS FASLG
16 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 8.62 HLA-DQB1 HLA-DRB1

Molecular functions related to Type Ii Mixed Cryoglobulinemia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 peptide antigen binding GO:0042605 8.96 HLA-DQB1 HLA-DRB1
2 MHC class II receptor activity GO:0032395 8.62 HLA-DQB1 HLA-DRB1

Sources for Type Ii Mixed Cryoglobulinemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
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30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
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37 KEGG
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48 NDF-RT
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52 Novoseek
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55 OMIM via Orphanet
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60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
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70 UMLS via Orphanet
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