MCID: TYP024
MIFTS: 28

Type Ii Mixed Cryoglobulinemia malady

Neuronal, Nephrological, Respiratory, Bone categories

Summaries for Type Ii Mixed Cryoglobulinemia

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33MalaCards
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MalaCards: Type Ii Mixed Cryoglobulinemia, also known as mc type ii, is related to cryoglobulinemia and hepatitis c. An important gene associated with Type Ii Mixed Cryoglobulinemia is CD5 (CD5 molecule), and among its related pathways are Proteoglycans in cancer and Immune response Role of integrins in NK cells cytotoxicity. The compounds gliadin and indomethacin have been mentioned in the context of this disorder. Related mouse phenotypes are renal/urinary system and reproductive system.

Aliases & Classifications for Type Ii Mixed Cryoglobulinemia

Sources:
49Orphanet, 26ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal, Nephrological, Respiratory, Bone


Characteristics (Orphanet epidemiological data):

49
type ii mixed cryoglobulinemia:
Age of onset: Variable


Aliases & Descriptions:

type ii mixed cryoglobulinemia 49
mc type ii 49


External Ids:

ICD10 via Orphanet26 D89.1

Related Diseases for Type Ii Mixed Cryoglobulinemia

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Type Ii Mixed Cryoglobulinemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 114)
idRelated DiseaseScoreTop Affiliating Genes
1cryoglobulinemia31.6CD5, CD40LG
2hepatitis c31.2CD40LG, HLA-DRB1, FAS
3vasculitis30.8CD40LG, FN1
4hepatitis c virus10.8
5hepatitis e10.5
6hepatitis d10.5
7hepatitis a10.4
8membranous glomerulonephritis10.2
9membranoproliferative glomerulonephritis10.2
10proliferative glomerulonephritis10.2
11bone lymphoma10.2
12pyoderma gangrenosum10.2
13retinal vasculitis10.2
14indolent b cell lymphoma10.2
15celiac disease10.0HLA-DQB1
16myasthenia gravis10.0HLA-DQB1
17acute leukemia10.0BCR
18cervical cancer10.0HLA-DQB1
19human immunodeficiency virus infectious disease10.0FASLG
20lupus erythematosus10.0CD40LG
21endometriosis10.0FN1
22guillain-barre syndrome10.0CD40LG
23measles10.0CD40LG
24sarcoma10.0FN1
25common variable immune deficiency10.0CD40LG
26schistosomiasis10.0CD40LG
27glaucoma10.0FN1
28osteoarthritis10.0FN1
29hypertension10.0FN1
30lung cancer10.0FN1
31cystic fibrosis10.0FN1
32diabetic retinopathy10.0FN1
33lyme disease10.0CD40LG
34rubella10.0CD40LG
35pemphigus foliaceus10.0HLA-DRB1
36antiphospholipid syndrome10.0CD40LG
37malaria10.0HLA-DRB1
38pemphigus vulgaris10.0HLA-DRB1
39toxoplasmosis10.0CD40LG
40periodontal disease10.0FN1
41encephalomyelitis10.0FASLG, HLA-DQB1
42thrombocytopenia10.0CD40LG
43splenomegaly10.0FAS
44hyperthyroidism10.0HLA-DRB1
45leprosy10.0HLA-DRB1
46deficiency anemia10.0FN1, CD5
47dermatitis herpetiformis10.0HLA-DQB1
48myocardial infarction10.0FN1
49immunoglobulin alpha deficiency10.0HLA-DQB1, CD40LG
50sarcoidosis10.0HLA-DRB1, HLA-DQB1

Graphical network of the top 20 diseases related to Type Ii Mixed Cryoglobulinemia:



Diseases related to type ii mixed cryoglobulinemia

Clinical Features for Type Ii Mixed Cryoglobulinemia

Drugs & Therapeutics for Type Ii Mixed Cryoglobulinemia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Type Ii Mixed Cryoglobulinemia

Drug clinical trials:

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Search NIH Clinical Center for Type Ii Mixed Cryoglobulinemia

Search CenterWatch for Type Ii Mixed Cryoglobulinemia

Genetic Tests for Type Ii Mixed Cryoglobulinemia

Anatomical Context for Type Ii Mixed Cryoglobulinemia

Animal Models for Type Ii Mixed Cryoglobulinemia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Type Ii Mixed Cryoglobulinemia

Genetic Variations for Type Ii Mixed Cryoglobulinemia

Expression for genes affiliated with Type Ii Mixed Cryoglobulinemia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Type Ii Mixed Cryoglobulinemia

Search GEO for disease gene expression data for Type Ii Mixed Cryoglobulinemia.

Pathways for genes affiliated with Type Ii Mixed Cryoglobulinemia

Sources:
30KEGG, 12EMD Millipore, 54Reactome, 38NCBI BioSystems Database, 53R&D Systems, 56SinoBiological, 52QIAGEN
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Pathways related to Type Ii Mixed Cryoglobulinemia according to GeneCards/GeneDecks:

(show all 18)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0FN1
29.5FASLG, FN1
3
Immune response Antigen presentation by MHC class II
Hide members
9.5HLA-DRB1, HLA-DQB1
4
Hide members
9.5HLA-DRB1, HLA-DQB1
59.4CD40LG, FN1
69.2FAS, FASLG
7
Hide members
9.2FAS, FASLG
8
Signal transduction JNK pathway
Hide members
9.2FASLG, FAS
9
Hide members
9.2FASLG, FAS
109.2FASLG, FAS
11
Hide members
9.2FASLG, FAS
12
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9.0CD40LG, HLA-DRB1, HLA-DQB1
13
Hide members
9.0CD40LG, HLA-DRB1, HLA-DQB1
149.0HLA-DQB1, HLA-DRB1, CD40LG
15
Hide members
8.3FAS, FASLG, HLA-DQB1, CD40LG
168.3FAS, FASLG, FN1, BCR
17
Hide members
8.2FAS, FASLG, HLA-DQB1, HLA-DRB1
18
Hide members
7.7CD40LG, HLA-DRB1, HLA-DQB1, FASLG, FAS

Compounds for genes affiliated with Type Ii Mixed Cryoglobulinemia

Sources:
45Novoseek, 60Tocris Bioscience, 29IUPHAR, 11DrugBank, 50PharmGKB, 24HMDB, 2BitterDB
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Compounds related to Type Ii Mixed Cryoglobulinemia according to GeneCards/GeneDecks:

(show top 50)    (show all 70)
idCompoundScoreTop Affiliating Genes
1gliadin4510.4CD40LG
2indomethacin45 60 29 1113.4FN1
3pge24510.3FN1
4phosphatidylserine45 29 1112.2FASLG
5aspartate459.9CD40LG, FASLG
6bosentan45 1110.9FN1, FASLG
7amoxicillin45 50 1111.9CD40LG, HLA-DQB1
8cyclosporin a45 29 6011.8CD40LG, FN1
9h2o2459.8BCR, FASLG
10blys459.8BCR, CD40LG
11bamhi459.7BCR, HLA-DQB1
12(glc)4459.6FASLG, FAS
13atpo45 2910.6FASLG, FAS
14rituximab45 50 1111.5FASLG, CD40LG, BCR
15fluorochrome459.5BCR, CD40LG
16pmma459.4CD40LG, FN1
17cytochalasin d45 6010.4BCR, FN1, FASLG
18teniposide45 1110.4FASLG, FAS
19biotin45 11 2411.4CD40LG, FN1, FASLG
20imatinib45 50 1111.3BCR, FN1, FASLG
21hyaluronic acid45 2410.3FASLG, FN1, CD40LG
222-chlorodeoxyadenosine459.2CD40LG, FASLG, FAS
23cytarabine45 50 1111.2FAS, FASLG, BCR
24fludarabine45 1110.2CD40LG, FASLG, FAS
25ivig459.1FAS, FASLG, CD40LG
26rottlerin459.1CD40LG, FASLG, FAS
27tetracycline45 1110.1CD40LG, FASLG, FAS
28adriamycin459.1FAS, FASLG, FN1
29tgf beta1459.0FAS, FASLG, FN1
30ceramide459.0FAS, FASLG, BCR
31ionomycin458.9FAS, FASLG, CD40LG
32herbimycin a45 609.9CD40LG, FN1, FAS
33pd 98,059458.7FAS, FASLG, FN1, BCR
34ly294002458.7FAS, FASLG, FN1, BCR
35agar458.6FAS, FASLG, FN1, CD40LG
36polysaccharide458.6CD40LG, FN1, FASLG, FAS
37thymidine45 249.6BCR, FN1, FASLG, FAS
38rapamycin458.6CD40LG, FN1, FASLG, FAS
39doxorubicin45 50 1110.6FAS, FASLG, FN1, CD40LG
40actinomycin d458.6FAS, FASLG, FN1, CD40LG
41lactate458.6FAS, FASLG, FN1, CD40LG
42cisplatin45 50 60 1111.6FAS, FASLG, FN1, CD40LG
43aspirin45 50 29 2411.5FAS, FN1, CD40LG
44paraffin458.3CD40LG, CD5, FN1, FASLG, FAS
45oligonucleotide458.2FAS, FASLG, HLA-DQB1, HLA-DRB1, BCR
46genistein45 29 60 2 11 2413.2FAS, FASLG, FN1, CD40LG, BCR
47heparin45 29 11 2411.2FAS, FASLG, FN1, CD40LG, BCR
48cysteine458.1FAS, FASLG, FN1, CD40LG, BCR
49dexamethasone45 50 29 1110.9CD40LG, FN1, FASLG, FAS
50tyrosine457.4FAS, FASLG, HLA-DQB1, HLA-DRB1, FN1, CD5

GO Terms for genes affiliated with Type Ii Mixed Cryoglobulinemia

Sources:
16Gene Ontology
See all sources

Cellular components related to Type Ii Mixed Cryoglobulinemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class II protein complexGO:0426139.6HLA-DQB1, HLA-DRB1
2clathrin-coated endocytic vesicle membraneGO:0306699.6HLA-DRB1, HLA-DQB1
3integral to lumenal side of endoplasmic reticulum membraneGO:0715569.5HLA-DRB1, HLA-DQB1
4transport vesicle membraneGO:0306589.5HLA-DQB1, HLA-DRB1
5ER to Golgi transport vesicle membraneGO:0125079.4HLA-DQB1, HLA-DRB1
6trans-Golgi network membraneGO:0325889.2HLA-DRB1, HLA-DQB1
7external side of plasma membraneGO:0098977.9CD40LG, CD5, HLA-DRB1, FASLG, FAS
8plasma membraneGO:0058867.3HLA-DQB1, HLA-DRB1, CD5, CD40LG, BCR, FAS

Biological processes related to Type Ii Mixed Cryoglobulinemia according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1immunoglobulin production involved in immunoglobulin mediated immune responseGO:0023819.6HLA-DQB1, HLA-DRB1
2positive regulation of endothelial cell apoptotic processGO:20003539.5FASLG, CD40LG
3humoral immune response mediated by circulating immunoglobulinGO:0024559.5HLA-DRB1, HLA-DQB1
4inflammatory cell apoptotic processGO:0069259.4FASLG, FAS
5T cell costimulationGO:0312959.3CD5, HLA-DRB1, HLA-DQB1
6extrinsic apoptotic signaling pathway via death domain receptorsGO:0086259.2FASLG, FAS
7regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012398.9FASLG, FAS
8apoptotic signaling pathwayGO:0971908.8CD5, FASLG, FAS

Molecular functions related to Type Ii Mixed Cryoglobulinemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tumor necrosis factor receptor bindingGO:0051649.5CD40LG, FASLG
2MHC class II receptor activityGO:0323959.2HLA-DRB1, HLA-DQB1

Products for genes affiliated with Type Ii Mixed Cryoglobulinemia

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  • Lysates
  • Antibodies

Sources for Type Ii Mixed Cryoglobulinemia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet