MCID: TYP007
MIFTS: 62

Typhoid Fever malady

Rare diseases, Infectious diseases categories
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Summaries for Typhoid Fever

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Disease Ontology:8 A primary bacterial infectious disease that is a communicable systemic illness, has material basis in salmonella enterica subsp enterica serovar typhi, which is transmitted by ingestion of food or water contaminated with the feces of an infected person. the infection has symptom fever, has symptom diarrhea, has symptom prostration, has symptom headache, has symptom splenomegaly, has symptom liver enlargement, has symptom eruption of rose-colored spots, and has symptom leukopenia.

MalaCards based summary: Typhoid Fever, also known as typhoid, is related to malaria and influenza, and has symptoms including epigastralgia/heartburn/gastric/duodenal ulcer/gastritis, acute abdominal pain/colic and facial pain/cephalalgia/migraine. An important gene associated with Typhoid Fever is OMP (olfactory marker protein), and among its related pathways are Salmonella infection and Immune response IFN gamma signaling pathway. The drug ciprofloxacin and the compounds flagellin and peptidoglycan have been mentioned in the context of this disorder. Affiliated tissues include testes, liver and bone, and related mouse phenotypes are tumorigenesis and hematopoietic system.

CDC:3 Typhoid fever is a life-threatening illness caused by the bacterium Salmonella Typhi. In the United States, it is estimated that approximately 5,700 cases occur annually.  Most cases (up to 75%) are acquired while traveling internationally. Typhoid fever is still common in the developing world, where it affects about 21.5 million persons each year.

Wikipedia:65 Typhoid fever ? also known simply as typhoid ? is a common worldwide bacterial disease transmitted by... more...

Aliases & Classifications for Typhoid Fever

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 62UMLS, 57SNOMED-CT, 34MeSH, 27ICD9CM, 39NCIt, 26ICD10 via Orphanet, 25ICD10
See all sources

Typhoid Fever, Aliases & Descriptions:

Name: Typhoid Fever 8 42 10 44 48 62
Typhoid 8 42 48
Typhoid Infection 8 62
Paratyphoid Fever 48 62
 
Enteric Fever 42 48
Typhoidal Salmonellosis 48
Fever: Typhoid 8
Enteric 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Infectious diseases


Characteristics (Orphanet epidemiological data):

48
typhoid fever:
Inheritance: Sporadic; Age of onset: Variable; Age of death: Child / adolescent


External Ids:

Disease Ontology8 DOID:13258
MeSH34 D014435
ICD9CM27 002.0
NCIt39 C35089
ICD10 via Orphanet26 A01.0
ICD1025 A01.0

Related Diseases for Typhoid Fever

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Graphical network of the top 20 diseases related to Typhoid Fever:



Diseases related to typhoid fever

Symptoms for Typhoid Fever

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Symptoms:

48 (show all 29)
  • epigastralgia/heartburn/gastric/duodenal ulcer/gastritis
  • acute abdominal pain/colic
  • facial pain/cephalalgia/migraine
  • insomnia
  • delirium/hallucination
  • fever/chilling
  • asthenia/fatigue/weakness
  • cutaneous rash
  • macules
  • hepatomegaly/liver enlargement (excluding storage disease)
  • splenomegaly
  • cardiac rhythm disorder/arrhythmia
  • ataxia/incoordination/trouble of the equilibrium
  • hypertonia/spasticity/rigidity/stiffness
  • hypereflexia
  • myalgia/muscular pain
  • articular/joint pain/arthralgia
  • acute diarrhea
  • constipation
  • gastrointestinal bleeding/hemorrhage/hematemesis/melena/rectorrhagia
  • intestinal perforation
  • cough
  • interstitial/restrictive pneumopathy/restrictive respiratory syndrome
  • collapse/sudden death/cardiac arrest/cardiorespiratory arrest
  • venous thrombosis/phlebitis/thrombophlebitis
  • encephalitis
  • tremor
  • obnubilation/coma/lethargia/desorientation
  • epistaxis/nose bleeding

HPO human phenotypes related to Typhoid Fever:

(show all 25)
id Description Frequency HPO Source Accession
1 hallucinations hallmark (90%) HP:0000738
2 abdominal pain hallmark (90%) HP:0002027
3 migraine hallmark (90%) HP:0002076
4 abnormality of the gastric mucosa hallmark (90%) HP:0004295
5 abnormality of temperature regulation hallmark (90%) HP:0004370
6 insomnia hallmark (90%) HP:0100785
7 skin rash typical (50%) HP:0000988
8 hypermelanotic macule typical (50%) HP:0001034
9 hypertonia typical (50%) HP:0001276
10 hyperreflexia typical (50%) HP:0001347
11 splenomegaly typical (50%) HP:0001744
12 hepatomegaly typical (50%) HP:0002240
13 incoordination typical (50%) HP:0002311
14 arthralgia typical (50%) HP:0002829
15 myalgia typical (50%) HP:0003326
16 epistaxis occasional (7.5%) HP:0000421
17 tremor occasional (7.5%) HP:0001337
18 sudden cardiac death occasional (7.5%) HP:0001645
19 diarrhea occasional (7.5%) HP:0002014
20 constipation occasional (7.5%) HP:0002019
21 restrictive lung disease occasional (7.5%) HP:0002091
22 gastrointestinal hemorrhage occasional (7.5%) HP:0002239
23 encephalitis occasional (7.5%) HP:0002383
24 reduced consciousness/confusion occasional (7.5%) HP:0004372
25 thrombophlebitis occasional (7.5%) HP:0004418

Drugs & Therapeutics for Typhoid Fever

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Drug clinical trials:

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Search NIH Clinical Center for Typhoid Fever

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Typhoid Fever

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Anatomical Context for Typhoid Fever

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MalaCards organs/tissues related to Typhoid Fever:

32
Testes, Liver, Bone, Bone marrow, Colon, Spleen, Thyroid, Whole blood, Small intestine, Ovary

Animal Models for Typhoid Fever or affiliated genes

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MGI Mouse Phenotypes related to Typhoid Fever:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.8SLC11A1, CASP1, IFNGR1
2MP:00053978.6SLC11A1, RHD, CASP1, IFNGR1

Publications for Typhoid Fever

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Articles related to Typhoid Fever:

(show top 50)    (show all 564)
idTitleAuthorsYear
1
Comparison between azithromycin and cefixime in the treatment of typhoid fever in children. (25178594)
2014
2
Out of Africa: Links Between Invasive Nontyphoidal Salmonella Disease, Typhoid Fever, and Malaria. (24336912)
2014
3
Cost of illness due to typhoid Fever in pemba, zanzibar, East Africa. (25395900)
2014
4
Multiple ileal perforations and concomitant cholecystitis with gall bladder gangrene as complication of typhoid fever. (25037301)
2014
5
Typhoid fever in Fiji: a reversible plague? (25066005)
2014
6
Typhoid fever in paediatric patients in Quetta, Balochistan, Pakistan. (24353661)
2013
7
Formative research and development of an evidence-based communication strategy: the introduction of Vi typhoid fever vaccine among school-aged children in Karachi, Pakistan. (23330632)
2013
8
Availability of clean tap water and medical services prevents the incidence of typhoid Fever. (24159533)
2013
9
Apropos "evaluation of serological diagnostic tests for typhoid Fever in papua new Guinea using a composite reference standard". (23359461)
2013
10
Ileal perforation due to typhoid fever - review of operative management and outcome in an urban centre in Nigeria. (23403212)
2013
11
Insights from the genome sequence of a Salmonella enterica serovar Typhi strain associated with a sporadic case of typhoid fever in Malaysia. (22933756)
2012
12
Host factors and typhoid fever-associated intestinal perforation in children in Nigeria. (22648130)
2012
13
Sensitivity and specificity of typhoid fever rapid antibody tests for laboratory diagnosis at two sub-Saharan African sites. (21897484)
2011
14
Safety, immunogenicity and dose ranging of a new Vi-CRMa88a88a88 conjugate vaccine against typhoid fever: randomized clinical testing in healthy adults. (21980445)
2011
15
Validation of the Dri-Dot Latex agglutination and IgM lateral flow assays for the diagnosis of typhoid fever in an Egyptian population. (21658878)
2011
16
Peptides representing the specific variable regions but not the full porin proteins can be useful for antibody based diagnosis of typhoid fever. (20941590)
2010
17
Treatment cost for typhoid fever at two hospitals in Kolkata, India. (20099755)
2009
18
Typhoid fever in southern Taiwan: a medical center experience. (19054916)
2008
19
Imported typhoid fever with hepatitis from Bangladesh: a case of delayed response to ceftriaxone? (19006514)
2008
20
Typhoid fever research in developing countries. (19745515)
2008
21
Polymorphisms in proinflammatory genes and susceptibility to typhoid fever and paratyphoid fever. (17477815)
2007
22
Plasma D-dimer levels in patients with typhoid fever. (18041311)
2007
23
Typhoid fever as a cause of opportunistic infection: case report. (16504150)
2006
24
Enhanced detection rate of typhoid fever in children in a periurban slum in Karachi, Pakistan using polymerase chain reaction technology. (16901852)
2006
25
Acute acalculous cholecystitis: A rare presentation of typhoid fever in adults. (16500779)
2006
26
Ultrasound in the diagnosis of typhoid fever. (16936362)
2006
27
Use of paired serum samples for serodiagnosis of typhoid fever. (16145168)
2005
28
A mass vaccination campaign targeting adults and children to prevent typhoid fever in Hechi; expanding the use of Vi polysaccharide vaccine in southeast China: a cluster-randomized trial. (15904514)
2005
29
Typhoid fever and viral hepatitis in a G6PD deficient individual. (16599045)
2005
30
Typhoid fever and typhoid hepatitis in Taiwan. (16274504)
2005
31
Rapid diagnosis of typhoid fever by enzyme-linked immunosorbent assay detection of Salmonella serotype typhi antigens in urine. (15031525)
2004
32
Osler on typhoid fever: differentiating typhoid from typhus and malaria. (15081508)
2004
33
Sexual transmission of typhoid fever: a multistate outbreak among men who have sex with men. (12830419)
2003
34
Immunisation against hepatitis A, hepatitis B and typhoid fever via combined vaccination: rationale, immunogenicity and reactogenicity. (12785871)
2003
35
Use of vaccines for the prevention of typhoid fever. (14660833)
2003
36
William Budd and typhoid fever. (12411628)
2002
37
An open randomized study of inactivated hepatitis A vaccine administered concomitantly with typhoid fever and yellow fever vaccines. (12044272)
2002
38
Typhoid fever and genetic polymorphisms at the natural resistance-associated macrophage protein 1. (11237848)
2001
39
Animal models of Salmonella infections: enteritis versus typhoid fever. (11755423)
2001
40
Blood culture confirmed typhoid fever in a provincial hospital in the Philippines. (11944712)
2001
41
An outbreak of typhoid fever, Xing-An County, People's Republic of China, 1999: estimation of the field effectiveness of Vi polysaccharide typhoid vaccine. (11372030)
2001
42
Differentiation of typhoid fever from fulminant hepatic failure in patients presenting with jaundice and encephalopathy. (10807074)
2000
43
Systemic lupus erythematosus-associated catastrophic antiphospholipid syndrome occurring after typhoid fever: a possible role of Salmonella lipopolysaccharide in the occurrence of diffuse vasculopathy-coagulopathy. (10323464)
1999
44
Typhoid fever presenting as infection-associated hemophagocytic syndrome: report of one case. (10910545)
1999
45
Rapid serologic diagnosis of pediatric typhoid fever in an endemic area: a prospective comparative evaluation of two dot-enzyme immunoassays and the Widal test. (10548305)
1999
46
Orchitis--an unusual complication of typhoid fever. (2632524)
1989
47
Toxic megacolon in typhoid fever. (4062466)
1985
48
Thyroxine, triiodothyronine and thyrotrophin levels in meningococcal meningitis, typhoid fever and other febrile conditions. (719910)
1978
49
Typhoid fever and intestinal perforation: Recovery with chloromycetin and dihydrostreptomycin. (14796868)
1950
50
Caries of Frontal Bone and Intracranial Abscess due to Bacillus typhosus Eleven Years after Attack of Typhoid Fever. (19976388)
1912

Variations for Typhoid Fever

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Expression for genes affiliated with Typhoid Fever

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Expression patterns in normal tissues for genes affiliated with Typhoid Fever

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Pathways for genes affiliated with Typhoid Fever

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Pathways related to Typhoid Fever according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5CASP1, IFNGR1
2
Show member pathways
IFN-gamma pathway37
9.5CASP1, IFNGR1

Compounds for genes affiliated with Typhoid Fever

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 50PharmGKB
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Compounds related to Typhoid Fever according to GeneCards/GeneDecks:

(show all 11)
idCompoundScoreTop Affiliating Genes
1flagellin44 2810.8CASP1, OMP
2peptidoglycan44 2810.7CASP1, OMP
3phosphatidylserine44 28 1111.4RHD, CASP1
4homocysteine44 2410.3RHD, TCN2
5galactose449.2GALE, RHD
6aspartate449.1CASP1, RHD, SLC11A1
7zinc44 2410.0OMP, CASP1, SLC11A1
8iron44 2410.0SLC11A1, RHD, IFNGR1, OMP
9polysaccharide448.9GALE, RHD, OMP
10oxygen44 249.8IFNGR1, CASP1, RHD, SLC11A1
11calcium44 50 24 1111.3SLC11A1, RHD, CASP1, OMP

GO Terms for genes affiliated with Typhoid Fever

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Biological processes related to Typhoid Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to lipopolysaccharideGO:0324969.2SLC11A1, CASP1
2signal transductionGO:0071659.2CASP1, IFNGR1, OMP

Products for genes affiliated with Typhoid Fever

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  • Antibodies
  • Proteins
  • Lysates

Sources for Typhoid Fever

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet