MCID: TYP007
MIFTS: 60

Typhoid Fever malady

Rare diseases, Infectious diseases categories

Summaries for Typhoid Fever

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9Disease Ontology, 4CDC, 66Wikipedia, 34MalaCards
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Disease Ontology:9 A primary bacterial infectious disease that is a communicable systemic illness, has material basis in salmonella enterica subsp enterica serovar typhi, which is transmitted by ingestion of food or water contaminated with the feces of an infected person. the infection has symptom fever, has symptom diarrhea, has symptom prostration, has symptom headache, has symptom splenomegaly, has symptom liver enlargement, has symptom eruption of rose-colored spots, and has symptom leukopenia.

MalaCards: Typhoid Fever, also known as typhoid, is related to malaria and influenza, and has symptoms including epistaxis/nose bleeding, fever and obnubilation/coma/lethargia/desorientation. An important gene associated with Typhoid Fever is OMP (olfactory marker protein), and among its related pathways are Salmonella infection and Immune response IFN gamma signaling pathway. The drug ciprofloxacin and the compounds flagellin and peptidoglycan have been mentioned in the context of this disorder. Affiliated tissues include testes, liver and bone, and related mouse phenotypes are tumorigenesis and hematopoietic system.

CDC:4 Typhoid fever is a life-threatening illness caused by the bacterium Salmonella Typhi. In the United States, it is estimated that approximately 5,700 cases occur annually.  Most cases (up to 75%) are acquired while traveling internationally. Typhoid fever is still common in the developing world, where it affects about 21.5 million persons each year.

Wikipedia:66 Typhoid fever ? also known simply as typhoid ? is a common worldwide bacterial disease transmitted by... more...

Aliases & Classifications for Typhoid Fever

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9Disease Ontology, 44NIH Rare Diseases, 11DISEASES, 46Novoseek, 50Orphanet, 63UMLS, 59SNOMED-CT, 28ICD9CM, 41NCIt, 36MeSH, 27ICD10 via Orphanet, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Infectious diseases


Characteristics (Orphanet epidemiological data):

50
typhoid fever:
Inheritance: Sporadic; Age of onset: Variable; Age of death: Child / adolescent


Aliases & Descriptions:

typhoid fever 9 44 11 46 50 63
typhoid 9 44 50
paratyphoid fever 50 63
enteric fever 44 50
typhoidal salmonellosis 50
typhoid infection 9
fever: typhoid 9
enteric 9


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Disease Ontology9 DOID:13258
ICD9CM28 002.0
NCIt41 C35089
MeSH36 D014435
ICD10 via Orphanet27 A01.0
ICD1026 A01.0

Related Diseases for Typhoid Fever

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18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Typhoid Fever:



Diseases related to typhoid fever

Symptoms for Typhoid Fever

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50Orphanet
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Symptoms:

50 (show all 36)
  • epistaxis/nose bleeding
  • fever
  • obnubilation/coma/lethargia/desorientation
  • tremor
  • leukopenia
  • encephalitis
  • diarrhea
  • prostration
  • headache
  • splenomegaly
  • liver enlargement
  • eruption of rose-colored spots
  • fever/chilling
  • venous thrombosis/phlebitis/thrombophlebitis
  • collapse/sudden death/cardiac arrest/cardiorespiratory arrest
  • hepatomegaly/liver enlargement (excluding storage disease)
  • macules
  • cutaneous rash
  • asthenia/fatigue/weakness
  • delirium/hallucination
  • insomnia
  • facial pain/cephalalgia/migraine
  • acute abdominal pain/colic
  • cardiac rhythm disorder/arrhythmia
  • ataxia/incoordination/trouble of the equilibrium
  • hypertonia/spasticity/rigidity/stiffness
  • interstitial/restrictive pneumopathy/restrictive respiratory syndrome
  • cough
  • intestinal perforation
  • gastrointestinal bleeding/hemorrhage/hematemesis/melena/rectorrhagia
  • constipation
  • acute diarrhea
  • articular/joint pain/arthralgia
  • myalgia/muscular pain
  • hypereflexia
  • epigastralgia/heartburn/gastric/duodenal ulcer/gastritis

Drugs & Therapeutics for Typhoid Fever

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Typhoid Fever

Drug clinical trials:

Search ClinicalTrials for Typhoid Fever

Search NIH Clinical Center for Typhoid Fever

Search CenterWatch for Typhoid Fever

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Typhoid Fever

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Anatomical Context for Typhoid Fever

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34MalaCards
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MalaCards organs/tissues related to Typhoid Fever:

34
Testes, Liver, Bone, Bone marrow, Colon, Thyroid, Spleen, Small intestine, Ovary, Whole blood

Animal Models for Typhoid Fever or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Typhoid Fever:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.8SLC11A1, CASP1, IFNGR1
2MP:00053978.6SLC11A1, RHD, CASP1, IFNGR1

Publications for Typhoid Fever

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53PubMed
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Articles related to Typhoid Fever:

(show top 50)    (show all 546)
idTitleAuthorsYear
1
Out of Africa: Links Between Invasive Nontyphoidal Salmonella Disease, Typhoid Fever, and Malaria. (24336912)
2014
2
Typhoid fever in paediatric patients in Quetta, Balochistan, Pakistan. (24353661)
2013
3
Formative research and development of an evidence-based communication strategy: the introduction of Vi typhoid fever vaccine among school-aged children in Karachi, Pakistan. (23330632)
2013
4
Availability of clean tap water and medical services prevents the incidence of typhoid Fever. (24159533)
2013
5
Apropos "evaluation of serological diagnostic tests for typhoid Fever in papua new Guinea using a composite reference standard". (23359461)
2013
6
Ileal perforation due to typhoid fever - review of operative management and outcome in an urban centre in Nigeria. (23403212)
2013
7
The role of abdominal ultrasound in the diagnosis of typhoid fever: An observational study. (24144458)
2013
8
Insights from the genome sequence of a Salmonella enterica serovar Typhi strain associated with a sporadic case of typhoid fever in Malaysia. (22933756)
2012
9
Host factors and typhoid fever-associated intestinal perforation in children in Nigeria. (22648130)
2012
10
Sensitivity and specificity of typhoid fever rapid antibody tests for laboratory diagnosis at two sub-Saharan African sites. (21897484)
2011
11
Safety, immunogenicity and dose ranging of a new Vi-CRMa88a88a88 conjugate vaccine against typhoid fever: randomized clinical testing in healthy adults. (21980445)
2011
12
Validation of the Dri-Dot Latex agglutination and IgM lateral flow assays for the diagnosis of typhoid fever in an Egyptian population. (21658878)
2011
13
Peptides representing the specific variable regions but not the full porin proteins can be useful for antibody based diagnosis of typhoid fever. (20941590)
2010
14
Treatment cost for typhoid fever at two hospitals in Kolkata, India. (20099755)
2009
15
Typhoid fever in southern Taiwan: a medical center experience. (19054916)
2008
16
Imported typhoid fever with hepatitis from Bangladesh: a case of delayed response to ceftriaxone? (19006514)
2008
17
Typhoid fever research in developing countries. (19745515)
2008
18
Polymorphisms in proinflammatory genes and susceptibility to typhoid fever and paratyphoid fever. (17477815)
2007
19
Plasma D-dimer levels in patients with typhoid fever. (18041311)
2007
20
Acute pancreatitis complicating typhoid fever in a 4-year-old girl. (18045312)
2007
21
Typhoid fever as a cause of opportunistic infection: case report. (16504150)
2006
22
Effects of pefloxacin in multi drug resistant typhoid fever. (16639809)
2006
23
Enhanced detection rate of typhoid fever in children in a periurban slum in Karachi, Pakistan using polymerase chain reaction technology. (16901852)
2006
24
Acute acalculous cholecystitis: A rare presentation of typhoid fever in adults. (16500779)
2006
25
Ultrasound in the diagnosis of typhoid fever. (16936362)
2006
26
Use of paired serum samples for serodiagnosis of typhoid fever. (16145168)
2005
27
A mass vaccination campaign targeting adults and children to prevent typhoid fever in Hechi; expanding the use of Vi polysaccharide vaccine in southeast China: a cluster-randomized trial. (15904514)
2005
28
Typhoid fever and viral hepatitis in a G6PD deficient individual. (16599045)
2005
29
Typhoid fever and typhoid hepatitis in Taiwan. (16274504)
2005
30
Rapid diagnosis of typhoid fever by enzyme-linked immunosorbent assay detection of Salmonella serotype typhi antigens in urine. (15031525)
2004
31
Osler on typhoid fever: differentiating typhoid from typhus and malaria. (15081508)
2004
32
Sexual transmission of typhoid fever: a multistate outbreak among men who have sex with men. (12830419)
2003
33
Immunisation against hepatitis A, hepatitis B and typhoid fever via combined vaccination: rationale, immunogenicity and reactogenicity. (12785871)
2003
34
Use of vaccines for the prevention of typhoid fever. (14660833)
2003
35
William Budd and typhoid fever. (12411628)
2002
36
An open randomized study of inactivated hepatitis A vaccine administered concomitantly with typhoid fever and yellow fever vaccines. (12044272)
2002
37
Typhoid fever and genetic polymorphisms at the natural resistance-associated macrophage protein 1. (11237848)
2001
38
Animal models of Salmonella infections: enteritis versus typhoid fever. (11755423)
2001
39
Blood culture confirmed typhoid fever in a provincial hospital in the Philippines. (11944712)
2001
40
An outbreak of typhoid fever, Xing-An County, People's Republic of China, 1999: estimation of the field effectiveness of Vi polysaccharide typhoid vaccine. (11372030)
2001
41
Differentiation of typhoid fever from fulminant hepatic failure in patients presenting with jaundice and encephalopathy. (10807074)
2000
42
Systemic lupus erythematosus-associated catastrophic antiphospholipid syndrome occurring after typhoid fever: a possible role of Salmonella lipopolysaccharide in the occurrence of diffuse vasculopathy-coagulopathy. (10323464)
1999
43
Typhoid fever presenting as infection-associated hemophagocytic syndrome: report of one case. (10910545)
1999
44
Rapid serologic diagnosis of pediatric typhoid fever in an endemic area: a prospective comparative evaluation of two dot-enzyme immunoassays and the Widal test. (10548305)
1999
45
Orchitis--an unusual complication of typhoid fever. (2632524)
1989
46
Intestinal perforation in typhoid fever: a historical and state-of-the-art review. (3890098)
1985
47
Toxic megacolon in typhoid fever. (4062466)
1985
48
Thyroxine, triiodothyronine and thyrotrophin levels in meningococcal meningitis, typhoid fever and other febrile conditions. (719910)
1978
49
Typhoid fever and intestinal perforation: Recovery with chloromycetin and dihydrostreptomycin. (14796868)
1950
50
Caries of Frontal Bone and Intracranial Abscess due to Bacillus typhosus Eleven Years after Attack of Typhoid Fever. (19976388)
1912

Variations for Typhoid Fever

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Expression for genes affiliated with Typhoid Fever

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Typhoid Fever

Search GEO for disease gene expression data for Typhoid Fever.

Pathways for genes affiliated with Typhoid Fever

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51PathCards, 31KEGG, 61Thomson Reuters, 39NCBI BioSystems Database
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Pathways related to Typhoid Fever according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5CASP1, IFNGR1
2
Show member pathways
IFN-gamma pathway39
9.5CASP1, IFNGR1

Compounds for genes affiliated with Typhoid Fever

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46Novoseek, 30IUPHAR, 12DrugBank, 25HMDB, 52PharmGKB
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Compounds related to Typhoid Fever according to GeneCards/GeneDecks:

(show all 11)
idCompoundScoreTop Affiliating Genes
1flagellin46 3010.8CASP1, OMP
2peptidoglycan46 3010.7CASP1, OMP
3phosphatidylserine46 30 1211.4RHD, CASP1
4homocysteine46 2510.3RHD, TCN2
5galactose469.2GALE, RHD
6aspartate469.1CASP1, RHD, SLC11A1
7zinc46 2510.0OMP, CASP1, SLC11A1
8iron46 2510.0SLC11A1, RHD, IFNGR1, OMP
9polysaccharide468.9GALE, RHD, OMP
10oxygen46 259.8IFNGR1, CASP1, RHD, SLC11A1
11calcium46 52 25 1211.3SLC11A1, RHD, CASP1, OMP

GO Terms for genes affiliated with Typhoid Fever

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17Gene Ontology
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Biological processes related to Typhoid Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to lipopolysaccharideGO:0324969.2SLC11A1, CASP1
2signal transductionGO:0071659.2CASP1, IFNGR1, OMP

Products for genes affiliated with Typhoid Fever

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Typhoid Fever

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet