MCID: TYP007
MIFTS: 67

Typhoid Fever

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Typhoid Fever

MalaCards integrated aliases for Typhoid Fever:

Name: Typhoid Fever 12 49 55 51 3 41 14 69
Typhoid 12 72 49 55
Typhoidal Salmonellosis 55
Enteric Fever 49

Characteristics:

Orphanet epidemiological data:

55
typhoid
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe),>1/1000 (South East Asia),1-5/10000 (Latin America),1-5/10000 (Africa),1-9/1000000 (North America),1-5/10000 (Oceania),1-9/1000000 (France); Age of onset: All ages; Age of death: adolescent,late childhood;

Classifications:

Orphanet: 55  
Rare infectious diseases


Summaries for Typhoid Fever

Disease Ontology : 12 A primary bacterial infectious disease that is a communicable systemic illness, has material basis in Salmonella enterica subsp enterica serovar Typhi, which is transmitted_by ingestion of food or water contaminated with the feces of an infected person. The infection has symptom fever, has symptom diarrhea, has symptom prostration, has symptom headache, has symptom splenomegaly, has symptom liver enlargement, has symptom eruption of rose-colored spots, and has symptom leukopenia.

MalaCards based summary : Typhoid Fever, also known as typhoid, is related to paratyphoid fever and salmonellosis, and has symptoms including fever, diarrhea and prostration. An important gene associated with Typhoid Fever is SLC11A1 (Solute Carrier Family 11 Member 1), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Azithromycin and Cefixime have been mentioned in the context of this disorder. Affiliated tissues include testes, liver and skin, and related phenotypes are homeostasis/metabolism and hematopoietic system

CDC : 3 Typhoid fever is a life-threatening illness caused by the bacterium Salmonella Typhi. An estimated 5,700 cases occur each year in the United States.  Most cases (up to 75%) are acquired while traveling internationally. Typhoid fever is still common in the developing world, where it affects about 21.5 million people each year.

Wikipedia : 72 Typhoid fever, also known simply as typhoid, is a bacterial infection due to Salmonella typhi that... more...

Related Diseases for Typhoid Fever

Diseases related to Typhoid Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 360)
# Related Disease Score Top Affiliating Genes
1 paratyphoid fever 32.5 CASP1 IFNGR1 TNF
2 salmonellosis 30.9 ALB CASP1 IFNG IFNGR1 IL1B SLC11A1
3 aseptic meningitis 30.0 IFNG IL1B TNF
4 neuritis 30.0 IFNG IL1B TNF
5 hepatitis b 29.9 ALB IFNG TLR4 TNF
6 intussusception 29.9 CFTR CRP IL6
7 schistosomiasis 29.8 ALB IFNG IFNGR1 TNF
8 hemorrhagic fever 29.8 ALB IFNG IL6 TNF
9 dengue hemorrhagic fever 29.8 ALB IFNG IL6 TNF
10 ileitis 29.8 IL6 TLR4 TLR5 TNF
11 tetanus 29.6 ALB IFNG LTA
12 helicobacter pylori infection 29.6 IFNG IFNGR1 IL1B TLR4 TNF
13 pertussis 29.6 IL1B IL6 TLR4 TNF
14 appendicitis 29.4 ALB CRP IL1B IL6 TNF
15 legionnaires' disease 29.3 ALB CASP1 OMP TLR4 TLR5
16 arthritis 29.1 IFNG IL1B IL6 LTA TNF
17 brucellosis 29.1 CRP IFNG IL6 SLC11A1 TLR4 TNF
18 gastroenteritis 28.9 ALB CRP IFNG IL1B IL6 TNF
19 peritonitis 28.8 ALB CRP IFNG IL1B IL6 TNF
20 meningitis 28.8 ALB CRP IFNG IL1B IL6 OMP
21 osteomyelitis 28.7 CASP1 IFNG IFNGR1 IL1B IL6 TNF
22 systemic lupus erythematosus 27.5 ALB CRP IFNG IL1B IL6 LTA
23 malaria 26.8 ALB CASP1 CRP IFNG IFNGR1 IL1B
24 typhoidal tularemia 12.1
25 dengue disease 11.3
26 interferon gamma, receptor 1, deficiency 10.5 IFNG IFNGR1
27 scorpion envenomation 10.5 IL6 TNF
28 autoimmune myocarditis 10.5 IFNG TNF
29 angioimmunoblastic lymphadenopathy with dysproteinemia 10.5 IL6 TNF
30 critical limb ischemia 10.5 IL6 TNF
31 hepatitis 10.5
32 variola major 10.5 IFNG TLR4
33 chronic beryllium disease 10.5 IFNG TNF
34 polyposis, gastric 10.4 IL1B TNF
35 trichosporonosis 10.4 IFNG TNF
36 trench fever 10.4 TLR4 TNF
37 lepromatous leprosy 10.4 IFNG IFNGR1 TNF
38 leprosy 3 10.4 IFNG SLC11A1 TNF
39 microscopic colitis 10.4 IFNG IL6 TNF
40 meconium aspiration syndrome 10.4 IFNG IL6 TNF
41 b-cell growth factor 10.4 IFNG IL6
42 intermediate uveitis 10.4 IFNG IL6 TNF
43 systemic onset juvenile idiopathic arthritis 10.4 IL1B TNF
44 tympanosclerosis 10.4 TLR4 TNF
45 hematopoietic stem cell transplantation 10.4 IFNG IL6 TNF
46 cytomegalovirus infection 10.4 IFNG IL6 TNF
47 plasmodium vivax malaria 10.4 IFNG IL6 TNF
48 cold agglutinin disease 10.4 CRP IL6
49 rasmussen encephalitis 10.4 IFNG IL6 TNF
50 mixed connective tissue disease 10.4 IFNG IL6 TNF

Graphical network of the top 20 diseases related to Typhoid Fever:



Diseases related to Typhoid Fever

Symptoms & Phenotypes for Typhoid Fever

Symptoms:

12
  • fever
  • diarrhea
  • prostration
  • headache
  • splenomegaly
  • liver enlargement
  • eruption of rose-colored spots
  • leukopenia

Human phenotypes related to Typhoid Fever:

55 31 (show all 27)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 epistaxis 55 31 occasional (7.5%) Occasional (29-5%) HP:0000421
2 skin rash 55 31 frequent (33%) Frequent (79-30%) HP:0000988
3 ataxia 55 31 frequent (33%) Frequent (79-30%) HP:0001251
4 lethargy 55 31 occasional (7.5%) Occasional (29-5%) HP:0001254
5 coma 55 31 occasional (7.5%) Occasional (29-5%) HP:0001259
6 hypertonia 55 31 frequent (33%) Frequent (79-30%) HP:0001276
7 tremor 55 31 occasional (7.5%) Occasional (29-5%) HP:0001337
8 hyperreflexia 55 31 frequent (33%) Frequent (79-30%) HP:0001347
9 cardiac arrest 55 31 occasional (7.5%) Occasional (29-5%) HP:0001695
10 splenomegaly 55 31 frequent (33%) Frequent (79-30%) HP:0001744
11 fever 55 31 hallmark (90%) Very frequent (99-80%) HP:0001945
12 diarrhea 55 31 occasional (7.5%) Occasional (29-5%) HP:0002014
13 constipation 55 31 occasional (7.5%) Occasional (29-5%) HP:0002019
14 abdominal pain 55 31 hallmark (90%) Very frequent (99-80%) HP:0002027
15 gastrointestinal hemorrhage 55 31 occasional (7.5%) Occasional (29-5%) HP:0002239
16 hepatomegaly 55 31 frequent (33%) Frequent (79-30%) HP:0002240
17 headache 55 31 hallmark (90%) Very frequent (99-80%) HP:0002315
18 encephalitis 55 31 occasional (7.5%) Occasional (29-5%) HP:0002383
19 arthralgia 55 31 frequent (33%) Frequent (79-30%) HP:0002829
20 myalgia 55 31 frequent (33%) Frequent (79-30%) HP:0003326
21 venous thrombosis 55 31 occasional (7.5%) Occasional (29-5%) HP:0004936
22 interstitial pulmonary abnormality 55 31 occasional (7.5%) Occasional (29-5%) HP:0006530
23 fatigue 55 31 hallmark (90%) Very frequent (99-80%) HP:0012378
24 macule 55 31 frequent (33%) Frequent (79-30%) HP:0012733
25 cough 55 31 occasional (7.5%) Occasional (29-5%) HP:0012735
26 insomnia 55 31 hallmark (90%) Very frequent (99-80%) HP:0100785
27 arrhythmia 55 Frequent (79-30%)

MGI Mouse Phenotypes related to Typhoid Fever:

43 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.28 IL1B CRP IFNG ALB CASP1 IFNGR1
2 hematopoietic system MP:0005397 10.23 IL1B IFNG CASP1 IFNGR1 CFTR RHD
3 cardiovascular system MP:0005385 10.21 CRP IFNG CASP1 IFNGR1 IL1B IL6
4 digestive/alimentary MP:0005381 10.19 IFNG ALB CASP1 IFNGR1 CFTR IL6
5 behavior/neurological MP:0005386 10.18 IFNGR1 CFTR IFNG OMP IL6 TLR4
6 immune system MP:0005387 10.18 CRP IFNG CASP1 IFNGR1 CFTR SLC11A1
7 endocrine/exocrine gland MP:0005379 10.13 CFTR ALB IFNG CASP1 IFNGR1 IL6
8 mortality/aging MP:0010768 10.07 ALB IFNG CASP1 IFNGR1 CFTR OMP
9 liver/biliary system MP:0005370 9.97 IFNG ALB IFNGR1 CFTR IL6 TLR4
10 integument MP:0010771 9.91 IFNGR1 IFNG CASP1 IL1B IL6 TLR4
11 neoplasm MP:0002006 9.81 IL1B IFNG ALB CASP1 IFNGR1 IL6
12 nervous system MP:0003631 9.61 IFNGR1 IFNG CASP1 IL1B OMP IL6
13 respiratory system MP:0005388 9.23 CFTR IFNG OMP IL6 TLR4 LTA

Drugs & Therapeutics for Typhoid Fever

Drugs for Typhoid Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 49)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azithromycin Approved Phase 4,Phase 3 83905-01-5 53477736 447043 55185
2
Cefixime Approved, Investigational Phase 4 79350-37-1 5362065 54362
3
Ceftriaxone Approved Phase 4 73384-59-5 5479530 5361919
4
Gatifloxacin Approved, Investigational Phase 4 112811-59-3 5379
5 Anti-Bacterial Agents Phase 4,Phase 3
6 Antibiotics, Antitubercular Phase 4
7 Anti-Infective Agents Phase 4,Phase 3,Phase 1,Phase 2
8 Antitubercular Agents Phase 4
9 Vaccines Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
10 Fluoroquinolones Phase 4
11 Nucleic Acid Synthesis Inhibitors Phase 4
12 Topoisomerase Inhibitors Phase 4
13
Sulfamethoxazole Approved Phase 3 723-46-6 5329
14
Trimethoprim Approved, Vet_approved Phase 3 738-70-5 5578
15
Lactitol Investigational Phase 3,Phase 2 585-86-4 3871
16 Antiparasitic Agents Phase 3,Phase 1,Phase 2
17 Antiprotozoal Agents Phase 3,Phase 1,Phase 2
18 Antimalarials Phase 3
19 Renal Agents Phase 3
20 Trimethoprim, Sulfamethoxazole Drug Combination Phase 3
21
Albendazole Approved, Vet_approved Phase 1, Phase 2 54965-21-8 2082
22
Metronidazole Approved Phase 1, Phase 2 443-48-1 4173
23
Secnidazole Approved Phase 1, Phase 2 3366-95-8
24
Zinc Approved, Investigational Phase 1, Phase 2 7440-66-6 32051 23994
25 Zinc sulfate Approved, Investigational Phase 1, Phase 2 7733-02-0
26
Formaldehyde Approved, Vet_approved Phase 2 50-00-0 712
27
Vitamin A Approved, Nutraceutical, Vet_approved Phase 2 68-26-8, 11103-57-4 445354
28 Antibodies Phase 2
29 Immunoglobulins Phase 2
30 Retinol palmitate Phase 2
31 Pharmaceutical Solutions Phase 1, Phase 2,Early Phase 1
32 Anthelmintics Phase 1, Phase 2
33 Antimitotic Agents Phase 1, Phase 2
34 Astringents Phase 1, Phase 2
35 Dermatologic Agents Phase 1, Phase 2
36 Micronutrients Phase 1, Phase 2
37 Trace Elements Phase 1, Phase 2
38 Heptavalent Pneumococcal Conjugate Vaccine Phase 2,Phase 1
39 Liver Extracts Phase 1, Phase 2
40 retinol Nutraceutical Phase 2
41 Lecithin Nutraceutical Phase 1, Phase 2
42 Soy Bean Nutraceutical Phase 1, Phase 2
43
Loperamide Approved Phase 1 53179-11-6 3955
44
Pectin Approved, Vet_approved Phase 1 9000-69-5 441476
45 Antidiarrheals Phase 1
46 Gastrointestinal Agents Phase 1
47 Cantharidin Approved, Investigational Early Phase 1 56-25-7
48
Ethanol Approved 64-17-5 702
49
BCG vaccine Investigational

Interventional clinical trials:

(show top 50) (show all 55)

# Name Status NCT ID Phase Drugs
1 Typhoid Fever: Combined vs. Single Antibiotic Therapy Unknown status NCT02224040 Phase 4 ceftriaxone;ceftriaxone and azithromycin;azithromycin;azithromycin and cefixime
2 Evaluation of the Vi Polysaccharide Vaccine Against Typhoid Fever Completed NCT00125008 Phase 4
3 Introduction of the Vi Polysaccharide Typhoid Vaccine in Hue City, Central Vietnam Completed NCT00131820 Phase 4
4 Typhoid Vi Vaccine Effectiveness in Hechi, Guangxi, China Completed NCT00131833 Phase 4
5 Combined Vi Vaccination and Health Education Program on the Burden of Typhoid in Childhood Completed NCT00125047 Phase 4
6 Gatifloxacin Versus Ceftriaxone in the Treatment of Enteric Fever Completed NCT01421693 Phase 4 Ceftriaxone;Gatifloxacin
7 Cross-reactive Immunity Elicited by Oral and Parenteral Typhoid Vaccines Recruiting NCT02121145 Phase 4
8 Effects of Aging on Primary and Secondary Vaccine Responses in a 15-Year Longitudinal Cohort Enrolling by invitation NCT03312699 Phase 4
9 Study of a Single Dose of SP093 Typhoid Vi Polysaccharide Vaccine in Japanese Subjects Completed NCT01608815 Phase 3
10 Comparative Study in Healthy Adults Aged 18-50 Yrs Administered With Hepatyrix or Havrix+Typherix or Tiphim Vi, to Compare Reactogenicity & Immunogenicity Completed NCT00197249 Phase 3
11 A Phase 3b, Randomized, Open-Label Study to Evaluate the Safety and Immunogenicity of Select Travel Vaccines When Administered Concomitantly With MenACWY in Adults Completed NCT01466387 Phase 3
12 Improving Rotavirus Vaccine Immune Response Completed NCT01825109 Phase 3
13 Nepal Undifferentiated Febrile Illness Trial Recruiting NCT02773407 Phase 3 Azithromycin;Co-trimoxazole
14 Clinical Efficacy of Typhoid Conjugate Vaccine (Vi-TCV) Among Children Age 9 Months Through 12 Years in Blantyre, Malawi Not yet recruiting NCT03299426 Phase 3
15 Dose Ranging Study to Determine the Safety, Reactogenicity and Immunogenicity of Typhoid Fever Vaccine (Ty800) in Healthy Adult Subjects Completed NCT00498654 Phase 2
16 Safety, Immunogenicity and Compatibility With DTP of a Typhoid Fever Vaccine in Infants Completed NCT00342628 Phase 2
17 Immunogenicity, Safety and Tolerability of the Typhoid Fever Vaccine Candidate M01ZH09 in Healthy Adults Completed NCT00679172 Phase 2
18 TY800 Dose Escalation (Typhoid) Completed NCT00269295 Phase 1, Phase 2 Placebo
19 Studies of Immune Responses to Orally Administered Vaccines in Developing Country Completed NCT01019083 Phase 1, Phase 2 Placebo;Placebo;Zinc Sulphate;Albendazole and Secnidazole
20 Safety and Immunogenicity of Vi-CRM197 Vaccine Against S. Typhi in Children, Older Infants and Infants Completed NCT01437267 Phase 2
21 Safety and Immunogenicity of Vi-CRM197 Vaccine Against S. Typhi in Adults, Children, Older Infants and Infants Completed NCT01229176 Phase 2
22 Extension Study of H01_04TP to Evaluate the Booster Response Induced by Vi-CRM197 in Adults Completed NCT01438996 Phase 2
23 Safety and Immunogenicity of Three Formulations of Vi-CRM197 Vaccine Against S. Typhi in Adults (18-40 Years Old) Completed NCT01193907 Phase 2
24 Study of ChimeriVax™ Tetravalent Dengue Vaccine in Healthy Subjects Completed NCT00875524 Phase 2
25 Safety and Efficacy Study of Mix Vaccine in Prostate Carcinoma Patient Completed NCT02338700 Phase 1, Phase 2
26 Safety and Efficacy Study of Mix Vaccine in Breast Carcinoma Patient Completed NCT02338804 Phase 1, Phase 2
27 Safety and Efficacy Study of Mix Vaccine in Hepatocyte Carcinoma Patient Completed NCT02338778 Phase 1, Phase 2
28 Safety and Efficacy Study of Mix Vaccine in Pancreatic Carcinoma Patient Completed NCT02338752 Phase 1, Phase 2
29 Understanding Typhoid Disease After Vaccination Active, not recruiting NCT01405521 Phase 2
30 Vaccines Against Salmonella Typhi Active, not recruiting NCT02324751 Phase 2
31 Vaccines and Dietary Oats in the Treatment of Ulcerative Colitis Terminated NCT00751933 Phase 2
32 Safety and Immunogenicity of a Vi-DT Typhoid Conjugate Vaccine Completed NCT02645032 Phase 1
33 CVD 909 Vi Prime Boost Study Completed NCT00326443 Phase 1 Placebo
34 Salmonella Typhi Vi O-Acetyl Pectin-rEPA Conjugate Vaccine Completed NCT00277147 Phase 1 BB IND 6989
35 Safety and Immunogenicity of Vi-CRM197 Vaccine Against S. Typhi in Adult (18-40 Years Old) Completed NCT01123941 Phase 1
36 Influence of Dietary Nitrate on Vascular Dysfunction and Inflammation Recruiting NCT02715635 Phase 1
37 Safety and Immunogenicity of Vi-DT Typhoid Conjugate Vaccine (Bio Farma) in Adults and Children (Phase I) Active, not recruiting NCT03109600 Phase 1
38 Intravesical Ty21a for the Treatment of Patients With Non-muscle-invasive Bladder Cancer (NMIBC) Not yet recruiting NCT03421236 Phase 1
39 Impact of Immune Challenge on Triple Network Connectivity in Humans Unknown status NCT02653235
40 Investigating the Effects of Typhoid Vaccine on Sleep in Healthy Volunteers Completed NCT02628054
41 Long Term Protection by and Persistence of Vi Antibodies Induced by Vi-rEPA Conjugate Vaccines in Vietnamese Children Injected at 2-5 Years or at 5-8 Years of Age Completed NCT00386789
42 Phase 4 Study To Assess The Safety Of Vivotif At Different Release Titers Among Travelers Completed NCT02391909
43 Investigation of the Influence of Gender on Cardiovascular Function Completed NCT01582321 Early Phase 1 Cantharidin
44 Role of BCG as Booster Vaccination Completed NCT02175420
45 Exploratory Study on the Mood and Cytokine Levels in Female Healthy Participants and Major Depressive Disorder Patients Completed NCT01533285 Early Phase 1
46 Rapid Diagnostic Tests and Clinical/Laboratory Predictors of Tropical Diseases In Patients With Persistent Fever in Cambodia, Nepal, Democratic Republic of the Congo and Sudan (NIDIAG-Fever) Completed NCT01766830
47 Global Genomic and Proteomic Profiling of African Children With Typhoid Fever Recruiting NCT02947295
48 Investigating Enteric Fever - Salmonella Typhi and Paratyphi Challenge Study Recruiting NCT02192008
49 Typhoid Vaccine in Testing Response to Immune Stress in Patients With Stage I-IIIA Breast Cancer Recruiting NCT02415387
50 Scrub Typhus RDT Study Recruiting NCT03269266

Search NIH Clinical Center for Typhoid Fever

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: typhoid fever

Genetic Tests for Typhoid Fever

Anatomical Context for Typhoid Fever

MalaCards organs/tissues related to Typhoid Fever:

38
Testes, Liver, Skin, Prostate, Bone, Bone Marrow, Colon

Publications for Typhoid Fever

Articles related to Typhoid Fever:

(show top 50) (show all 680)
# Title Authors Year
1
Comparison of Strategies and Incidence Thresholds for Vi Conjugate Vaccines Against Typhoid Fever: A Cost-effectiveness Modeling Study. ( 29444257 )
2018
2
A cross-sectional seroepidemiological survey of typhoid fever in Fiji. ( 28727726 )
2017
3
Correction to Supporting Information for Alvarez et al., Human genetic variation in<i>VAC14</i>regulates<i>Salmonella</i>invasion and typhoid fever through modulation of cholesterol. ( 29180409 )
2017
4
A large and persistent outbreak of typhoid fever caused by consuming contaminated water and street-vended beverages: Kampala, Uganda, January - June 2015. ( 28056940 )
2017
5
Salivary Anti-50 kDa Antibodies as a Useful Biomarker for Diagnosis of Typhoid Fever. ( 28764158 )
2017
6
The burden of typhoid fever in low- and middle-income countries: A meta-regression approach. ( 28241011 )
2017
7
Typhoid fever: A rare cause of relative bradycardia in Japan. ( 29264058 )
2017
8
Detection of typhoid fever by diatom-based optical biosensor. ( 28577141 )
2017
9
Bilateral retinitis following typhoid fever. ( 28405476 )
2017
10
Encephalitis in a traveller with typhoid fever: efficacy of corticosteroids. ( 29088483 )
2017
11
Induction of Cell Cycle and NK Cell Responses by Live-Attenuated Oral Vaccines against Typhoid Fever. ( 29075261 )
2017
12
Correction to: A large and persistent outbreak of typhoid fever caused by consuming contaminated water and street-vended beverages: Kampala, Uganda, January - June 2015. ( 29047373 )
2017
13
Updated estimates of typhoid fever burden in sub-Saharan Africa. ( 28911760 )
2017
14
Human genetic variation in VAC14 regulates Salmonella invasion and typhoid fever through modulation of cholesterol. ( 28827342 )
2017
15
Blood culture-PCR to optimise typhoid fever diagnosis after controlled human infection identifies frequent asymptomatic cases and evidence of primary bacteraemia. ( 28130144 )
2017
16
Importance of Salmonella Typhi-Responsive CD8+ T Cell Immunity in a Human Typhoid Fever Challenge Model. ( 28303138 )
2017
17
<i>Salmonella</i> Typhi Bactericidal Antibodies Reduce Disease Severity but Do Not Protect against Typhoid Fever in a Controlled Human Infection Model. ( 29387052 )
2017
18
Typhoid Fever and Acute Appendicitis: A Rare Association Not Yet Fully Formed. ( 29033762 )
2017
19
The impact of migration and antimicrobial resistance on the transmission dynamics of typhoid fever in Kathmandu, Nepal: A mathematical modelling study. ( 28475605 )
2017
20
Epidemiological characteristics and clinical treatment outcome of typhoid fever in Ningbo China, 2005-2014, PFGE results revealing great proportion of common transmission sources. ( 28367881 )
2017
21
Environmental Survey of Drinking Water Sources in Kampala, Uganda, during a Typhoid Fever Outbreak. ( 28970225 )
2017
22
Modifiable risk factors for typhoid intestinal perforations during a large outbreak of typhoid fever, Kampala Uganda, 2015. ( 28946853 )
2017
23
Reproducible diagnostic metabolites in plasma from typhoid fever patients in Asia and Africa. ( 28483042 )
2017
24
A Rare Coincidence of Measles with Typhoid Fever. ( 29104838 )
2017
25
Efficacy and immunogenicity of a Vi-tetanus toxoid conjugate vaccine in the prevention of typhoid fever using a controlled human infection model of Salmonella Typhi: a randomised controlled, phase 2b trial. ( 28965718 )
2017
26
Rhabdomyolysis Complicating Typhoid Fever in a Child and Review of the Literature. ( 28430751 )
2017
27
Review of current typhoid fever vaccines, cross-protection against paratyphoid fever, and the European guidelines. ( 28856924 )
2017
28
Signet-ring histiocytes in typhoid fever. ( 29217701 )
2017
29
Development of ELISAs for diagnosis of acute typhoid fever in Nigerian children. ( 28640809 )
2017
30
Social and Economic Burden Associated With Typhoid Fever in Kathmandu and Surrounding Areas: A Qualitative Study. ( 28973415 )
2017
31
Biomagnetic Pair Therapy and Typhoid Fever: A Pilot Study. ( 29067141 )
2017
32
Identification of Novel Serodiagnostic Signatures of Typhoid Fever Using a<i>Salmonella</i>Proteome Array. ( 28970824 )
2017
33
Determination of free polysaccharide in Vi glycoconjugate vaccine against typhoid fever. ( 28282600 )
2017
34
Modelling and Optimal Control of Typhoid Fever Disease with Cost-Effective Strategies. ( 29081828 )
2017
35
Comparison of Molecular Detection Method (Nested Polymerase Chain Reaction) with Blood Culture and Paired Widal test for the Rapid Diagnosis of Typhoid Fever. ( 28260765 )
2017
36
Expression of intra- and extracellular granzymes in patients with typhoid fever. ( 28749963 )
2017
37
An evaluation of purified Salmonella Typhi protein antigens for the serological diagnosis of acute typhoid fever. ( 28551371 )
2017
38
Role of computed tomography of abdomen in difficult to diagnose typhoid fever: a case series. ( 29145776 )
2017
39
Correction for Alvarez et al., Human genetic variation in<i>VAC14</i>regulates<i>Salmonella</i>invasion and typhoid fever through modulation of cholesterol. ( 29180411 )
2017
40
Typhoid Fever on the Half Shell. ( 28207076 )
2017
41
Development of a synthetic Vi polysaccharide vaccine for typhoid fever. ( 29150208 )
2017
42
Epidemiological investigation of an outbreak of typhoid fever in Jorhat town of Assam, India. ( 28256469 )
2016
43
Revisiting typhoid fever surveillance in low and middle income countries: lessons from systematic literature review of population-based longitudinal studies. ( 26822522 )
2016
44
Salmonella Typhi-specific multifunctional CD8+ T cells play a dominant role in protection from typhoid fever in humans. ( 26928826 )
2016
45
Typhoid Fever, Below the Belt. ( 26894114 )
2016
46
A Comparative Evaluation of Different Diagnostic Modalities in the Diagnosis of Typhoid Fever Using a Composite Reference Standard: A Tertiary Hospital Based Study in Central India. ( 27891335 )
2016
47
Typhoid fever: case report and literature review. ( 27392073 )
2016
48
Identification of Five Novel Salmonella Typhi-Specific Genes as Markers for Diagnosis of Typhoid Fever Using Single-Gene Target PCR Assays. ( 27975062 )
2016
49
Development of a live attenuated bivalent oral vaccine against Shigella sonnei shigellosis and typhoid fever. ( 27803169 )
2016
50
Third Generation Cephalosporins for Typhoid Fever. ( 27603449 )
2016

Variations for Typhoid Fever

Expression for Typhoid Fever

Search GEO for disease gene expression data for Typhoid Fever.

Pathways for Typhoid Fever

Pathways related to Typhoid Fever according to GeneCards Suite gene sharing:

(show top 50) (show all 71)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.03 CASP1 CRP IFNG IFNGR1 IL1B IL6
2
Show member pathways
13.66 CASP1 IFNG IFNGR1 IL1B IL6 LTA
3
Show member pathways
13.37 CASP1 IFNG IFNGR1 IL1B IL6 LTA
4
Show member pathways
13.2 IFNG IFNGR1 IL1B TLR4 TLR5 TNF
5
Show member pathways
13.02 CASP1 CFTR IL1B IL6 TLR4 TLR5
6
Show member pathways
12.86 IFNG IL1B IL6 LTA TNF
7
Show member pathways
12.75 IL1B IL6 LTA TLR4 TLR5 TNF
8
Show member pathways
12.74 CASP1 IFNG IL1B IL6 TNF
9
Show member pathways
12.69 IFNG IFNGR1 IL1B LTA TNF
10
Show member pathways
12.68 CASP1 IL1B LTA TLR4 TLR5 TNF
11
Show member pathways
12.66 CASP1 IFNG IFNGR1 IL1B IL6 LTA
12
Show member pathways
12.59 IFNG IFNGR1 IL1B IL6 TLR4 TLR5
13
Show member pathways
12.58 IFNG IL1B IL6 TNF
14
Show member pathways
12.56 IFNGR1 IL6 TLR4 TNF
15
Show member pathways
12.44 IFNG IL1B IL6 TNF
16
Show member pathways
12.44 IFNG IFNGR1 IL1B IL6 TLR4 TLR5
17
Show member pathways
12.39 ALB CRP IFNG IL1B IL6 TNF
18
Show member pathways
12.38 CFTR IFNG IL1B IL6 TLR5 TNF
19
Show member pathways
12.32 IFNG IFNGR1 IL1B TLR4 TNF
20
Show member pathways
12.29 IL6 TLR4 TLR5 TNF
21 12.25 IFNG IFNGR1 IL1B IL6 TLR4 TNF
22
Show member pathways
12.25 IFNG IFNGR1 IL1B IL6 TLR4 TNF
23
Show member pathways
12.24 IFNG IL1B IL6 LTA TNF
24
Show member pathways
12.21 CASP1 IFNG IFNGR1 IL1B TLR4 TNF
25 12.15 IFNG IFNGR1 IL6 TLR4 TLR5 TNF
26 12.1 IFNG IFNGR1 IL1B TNF
27 12.09 IFNG IL1B IL6 TLR4 TNF
28 12.02 IL1B IL6 LTA TNF
29
Show member pathways
12.01 IL1B TLR4 TLR5
30 11.98 IFNG IL6 TNF
31 11.98 IFNG IFNGR1 IL6 TLR4
32 11.97 IL1B IL6 TNF
33 11.96 IFNG IL1B IL6 TLR4 TNF
34 11.95 IL1B LTA TLR4 TNF
35 11.94 IFNG IL1B IL6
36
Show member pathways
11.94 CASP1 IFNG IFNGR1 IL1B
37
Show member pathways
11.91 IFNG IL1B IL6 TLR4 TLR5
38 11.9 IL1B IL6 TNF
39 11.9 IFNG IL1B IL6 TLR4 TNF
40 11.89 IL1B IL6 TNF
41
Show member pathways
11.87 CFTR IL6 TLR4
42 11.87 IFNG IL1B LTA TNF
43 11.83 IFNG IL1B IL6 TNF
44 11.82 CASP1 IL1B IL6 TLR4 TNF
45
Show member pathways
11.78 CFTR IFNG IFNGR1 IL1B IL6 TLR4
46
Show member pathways
11.75 IFNG IL1B IL6 TNF
47 11.69 IL1B IL6 TNF
48 11.65 IL6 LTA TLR4 TLR5 TNF
49
Show member pathways
11.64 IFNG IFNGR1 LTA TNF
50 11.63 CASP1 IFNG IFNGR1 IL1B IL6 TLR4

GO Terms for Typhoid Fever

Cellular components related to Typhoid Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.5 ALB CRP IFNG IL1B IL6 LTA
2 extracellular region GO:0005576 9.23 ALB CASP1 CRP IFNG IL1B IL6

Biological processes related to Typhoid Fever according to GeneCards Suite gene sharing:

(show all 49)
# Name GO ID Score Top Affiliating Genes
1 defense response to bacterium GO:0042742 9.95 SLC11A1 TLR4 TLR5 TNF
2 immune response GO:0006955 9.95 IFNG IL1B IL6 LTA SLC11A1 TLR4
3 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.93 CASP1 IL1B TLR4 TNF
4 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.91 IL1B IL6 TLR4 TNF
5 response to lipopolysaccharide GO:0032496 9.91 CASP1 IL1B LTA SLC11A1 TLR4
6 activation of MAPK activity GO:0000187 9.88 IL1B TLR4 TNF
7 response to virus GO:0009615 9.88 IFNG IFNGR1 TNF
8 positive regulation of DNA binding transcription factor activity GO:0051091 9.87 IL1B IL6 TNF
9 inflammatory response GO:0006954 9.87 CRP IL1B IL6 SLC11A1 TLR4 TLR5
10 defense response to Gram-positive bacterium GO:0050830 9.86 CRP IL6 LTA TNF
11 defense response to Gram-negative bacterium GO:0050829 9.85 IL6 SLC11A1 TLR4
12 regulation of inflammatory response GO:0050727 9.85 CASP1 TLR4 TNF
13 positive regulation of JNK cascade GO:0046330 9.84 IL1B TLR4 TNF
14 cellular response to mechanical stimulus GO:0071260 9.84 CASP1 IL1B TLR4 TLR5
15 regulation of insulin secretion GO:0050796 9.83 IFNG IL1B TNF
16 cellular response to lipopolysaccharide GO:0071222 9.83 CASP1 IL6 TLR4 TLR5 TNF
17 humoral immune response GO:0006959 9.8 IFNG IL6 LTA TNF
18 positive regulation of gene expression GO:0010628 9.8 CRP IFNG IL1B IL6 SLC11A1 TLR4
19 response to bacterium GO:0009617 9.78 CASP1 SLC11A1 TLR4
20 lipopolysaccharide-mediated signaling pathway GO:0031663 9.77 IL1B TLR4 TNF
21 positive regulation of phagocytosis GO:0050766 9.77 IL1B SLC11A1 TNF
22 positive regulation of interleukin-6 production GO:0032755 9.76 IL1B IL6 TLR4 TNF
23 positive regulation of NF-kappaB import into nucleus GO:0042346 9.74 IL1B TLR4 TNF
24 positive regulation of chemokine production GO:0032722 9.72 IL6 TLR4 TNF
25 negative regulation of lipid catabolic process GO:0050995 9.71 IL1B TNF
26 negative regulation of growth of symbiont in host GO:0044130 9.7 LTA TNF
27 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.7 IFNG IL1B TNF
28 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.69 IL1B TNF
29 regulation of interferon-gamma-mediated signaling pathway GO:0060334 9.69 IFNG IFNGR1
30 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.69 IL1B TNF
31 regulation of cytokine secretion GO:0050707 9.68 TLR4 TLR5
32 membrane hyperpolarization GO:0060081 9.68 CASP1 CFTR
33 negative regulation of interleukin-17 production GO:0032700 9.68 IFNG TLR4
34 macrophage activation GO:0042116 9.68 SLC11A1 TLR4
35 positive regulation of interleukin-8 production GO:0032757 9.67 IL1B TLR4 TLR5 TNF
36 positive regulation of chemokine biosynthetic process GO:0045080 9.66 IL1B TNF
37 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.66 TLR4 TNF
38 regulation of establishment of endothelial barrier GO:1903140 9.65 IL1B TNF
39 negative regulation of lipid storage GO:0010888 9.65 CRP IL6 TNF
40 interleukin-1 beta production GO:0032611 9.64 CASP1 IL1B
41 positive regulation of fever generation GO:0031622 9.63 IL1B TNF
42 sequestering of triglyceride GO:0030730 9.62 IL1B TNF
43 positive regulation of humoral immune response mediated by circulating immunoglobulin GO:0002925 9.62 LTA TNF
44 positive regulation of chronic inflammatory response to antigenic stimulus GO:0002876 9.58 LTA TNF
45 positive regulation of vitamin D biosynthetic process GO:0060557 9.58 IFNG TNF
46 positive regulation of interferon-gamma production GO:0032729 9.35 IL1B LTA SLC11A1 TLR4 TNF
47 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.33 IFNG IL1B TNF
48 positive regulation of nitric oxide biosynthetic process GO:0045429 9.02 IFNG IL1B TLR4 TLR5 TNF
49 regulation of receptor activity GO:0010469 10.04 IFNG IL1B IL6 LTA TNF

Molecular functions related to Typhoid Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 IFNG IL1B IL6 LTA TNF
2 interleukin-1 receptor binding GO:0005149 8.96 IL1B TLR5

Sources for Typhoid Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
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41 MeSH
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50 NINDS
51 Novoseek
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54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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