MCID: TYP007
MIFTS: 60

Typhoid Fever malady

Infectious category

Summaries for Typhoid Fever

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Disease Ontology:8 A primary bacterial infectious disease that is a communicable systemic illness, has material basis in salmonella enterica subsp enterica serovar typhi, which is transmitted by ingestion of food or water contaminated with the feces of an infected person. the infection has symptom fever, has symptom diarrhea, has symptom prostration, has symptom headache, has symptom splenomegaly, has symptom liver enlargement, has symptom eruption of rose-colored spots, and has symptom leukopenia.

MalaCards: Typhoid Fever, also known as typhoid, is related to cholera and paratyphoid fever, and has symptoms including epigastralgia/heartburn/gastric/duodenal ulcer/gastritis, acute abdominal pain/colic and facial pain/cephalalgia/migraine. An important gene associated with Typhoid Fever is OMP (olfactory marker protein), and among its related pathways are IL27-mediated signaling events and TRAF Pathway. The drug ciprofloxacin and the compounds ertapenem and moxalactam have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, whole blood and spleen, and related mouse phenotype hematopoietic system.

Wikipedia:64 Typhoid fever — also known simply as typhoid — is a common worldwide bacterial disease transmitted... more...

Aliases & Classifications for Typhoid Fever

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 49Orphanet, 61UMLS, 57SNOMED-CT, 35MeSH, 27ICD9CM, 40NCIt, 26ICD10 via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious


Characteristics (Orphanet epidemiological data):

49
typhoid fever:
Inheritance: Sporadic; Age of onset: Variable; Age of death: Child / adolescent


Aliases & Descriptions:

typhoid fever 8 43 10 45 49 61
typhoid 8 43 49
paratyphoid fever 49 61
enteric fever 43 49
typhoidal salmonellosis 49
typhoid infection 8
fever: typhoid 8
enteric 8


External Ids:

Disease Ontology8 DOID:13258
MeSH35 D014435
ICD9CM27 002.0
NCIt40 C35089
ICD10 via Orphanet26 A01.0
ICD1025 A01.0

Related Diseases for Typhoid Fever

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Typhoid Fever:



Diseases related to typhoid fever

Clinical Features for Typhoid Fever

Sources:
49Orphanet
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Symptoms:

49 (show all 36)
  • epigastralgia/heartburn/gastric/duodenal ulcer/gastritis
  • acute abdominal pain/colic
  • facial pain/cephalalgia/migraine
  • insomnia
  • delirium/hallucination
  • fever/chilling
  • asthenia/fatigue/weakness
  • cutaneous rash
  • macules
  • hepatomegaly/liver enlargement (excluding storage disease)
  • splenomegaly
  • cardiac rhythm disorder/arrhythmia
  • ataxia/incoordination/trouble of the equilibrium
  • hypertonia/spasticity/rigidity/stiffness
  • hypereflexia
  • myalgia/muscular pain
  • articular/joint pain/arthralgia
  • acute diarrhea
  • constipation
  • gastrointestinal bleeding/hemorrhage/hematemesis/melena/rectorrhagia
  • intestinal perforation
  • cough
  • interstitial/restrictive pneumopathy/restrictive respiratory syndrome
  • collapse/sudden death/cardiac arrest/cardiorespiratory arrest
  • venous thrombosis/phlebitis/thrombophlebitis
  • encephalitis
  • tremor
  • obnubilation/coma/lethargia/desorientation
  • epistaxis/nose bleeding
  • fever
  • diarrhea
  • prostration
  • headache
  • liver enlargement
  • eruption of rose-colored spots
  • leukopenia

Drugs & Therapeutics for Typhoid Fever

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Typhoid Fever

Drug clinical trials:

Search ClinicalTrials for Typhoid Fever

Search NIH Clinical Center for Typhoid Fever

Search CenterWatch for Typhoid Fever

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Typhoid Fever

Anatomical Context for Typhoid Fever

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Typhoid Fever:

33
Bone marrow, Whole blood, Spleen, Small intestine, Colon, Liver, Thyroid, Ovary, T cells, B cells

Animal Models for Typhoid Fever or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Typhoid Fever:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053979.6SLC11A1, IL12B, LTB, HIST1H1D, RHD, G6PD

Publications for Typhoid Fever

Sources:
51PubMed
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Articles related to Typhoid Fever:

(show top 50)    (show all 608)
idTitleAuthorsYear
1
Formative research and development of an evidence-based communication strategy: the introduction of Vi typhoid fever vaccine among school-aged children in Karachi, Pakistan. (23330632)
2013
2
Ileal perforation due to typhoid fever - review of operative management and outcome in an urban centre in Nigeria. (23403212)
2013
3
Immunogenicity and safety of the Vi-CRM197 conjugate vaccine against typhoid fever in adults, children, and infants in south and southeast Asia: results from two randomised, observer-blind, age de-escalation, phase 2 trials. (24290843)
2013
4
Targeting of putative fimbrial gene for detection of S. Typhi in typhoid fever and chronic typhoid carriers by nested PCR. (23857386)
2013
5
Evaluation of an electricity-free, culture-based approach for detecting typhoidal Salmonella bacteremia during enteric fever in a high burden, resource-limited setting. (23853696)
2013
6
Insights from the genome sequence of a Salmonella enterica serovar Typhi strain associated with a sporadic case of typhoid fever in Malaysia. (22933756)
2012
7
Typhoid Fever and the challenge of nonmalaria febrile illness in sub-saharan Africa. (22357701)
2012
8
Typhoid fever outbreak associated with frozen mamey pulp imported from Guatemala to the western United States, 2010. (22423132)
2012
9
Whole-genome sequences and comparative genomics of Salmonella enterica serovar Typhi isolates from patients with fatal and nonfatal typhoid fever in Papua New Guinea. (22933755)
2012
10
Cases of malaria, hepatitis A, and typhoid fever among VFRs, Quebec (Canada). (22017712)
2011
11
Evaluation of a newly developed ELISA against Widal, TUBEX-TF and Typhidot for typhoid fever surveillance. (21444985)
2011
12
Evaluation of newer rapid diagnostic tests for typhoid fever. (22680262)
2011
13
Treatment cost for typhoid fever at two hospitals in Kolkata, India. (20099755)
2009
14
Immunoblot analysis of sera in uncomplicated typhoid fever & with typhoid ileal perforation. (19535839)
2009
15
Importance of travel in domestically acquired typhoid fever infections: opportunities for prevention and early detection. (18509759)
2009
16
Comparison between DOT EIA IgM and Widal Test as early diagnosis of typhoid fever. (19182742)
2009
17
Vaccine desirability during an effectiveness trial of the typhoid fever polysaccharide Vi vaccine in Kolkata India. (19652547)
2009
18
Fluoroquinolones for treating typhoid and paratyphoid fever (enteric fever). (18843659)
2008
19
Typhoid fever in children in Africa. (18312473)
2008
20
Recombinant SpaO and H1a as immunogens for protection of mice from lethal infection with Salmonella paratyphi A: implications for rational design of typhoid fever vaccines. (18834913)
2008
21
Proteomics analysis of the causative agent of typhoid fever. (18166006)
2008
22
Outbreak of domestically acquired typhoid fever in Leipzig, Germany, June 2004. (17370984)
2007
23
Multidrug-resistant typhoid fever. (17264451)
2007
24
Perforation of the gall bladder following typhoid fever-induced ileal perforation. (18057437)
2007
25
Effects of pefloxacin in multi drug resistant typhoid fever. (16639809)
2006
26
Cardiopulmonary manifestations of typhoid fever: a prospective analysis of 65 cases in Iran. (16611453)
2006
27
The feasibility of a school-based VI polysaccharide vaccine mass immunization campaign in Hue City, central Vietnam: streamlining a typhoid fever preventive strategy. (17120972)
2006
28
Evaluation of typhoid assay for rapid diagnosis of typhoid fever. (16715625)
2006
29
Overlapping epidemiologies of hepatitis A and typhoid fever: the needs of the traveler. (16225802)
2005
30
Intussusception complicating typhoid fever. (16055906)
2005
31
Susceptibility to typhoid fever is associated with a polymorphism in the cystic fibrosis transmembrane conductance regulator (CFTR). (16078047)
2005
32
Malaria or typhoid fever: a diagnostic dilemma? (16378813)
2005
33
A clinical, microbiological, and pathological study of intestinal perforation associated with typhoid fever. (15206054)
2004
34
A randomized, open-label study of the immunogenicity and reactogenicity of three lots of a combined typhoid fever/hepatitis A vaccine in healthy adults. (15336473)
2004
35
Immunisation against hepatitis A, hepatitis B and typhoid fever via combined vaccination: rationale, immunogenicity and reactogenicity. (12785871)
2003
36
Ciprofloxacin treatment failure in typhoid fever case, Pakistan. (14720407)
2003
37
Typhoid fever in Kuala Lumpur and a comparative evaluation of two commercial diagnostic kits for the detection of antibodies to Salmonella typhi. (12437043)
2002
38
Retrospective analysis of typhoid fever in a tropical tertiary health facility. (12170927)
2002
39
Persistent fever in a case of typhoid--an unusual cause of neuroleptic malignant syndrome. (11225156)
2001
40
Unusual presentation of typhoid fever: cutaneous vasculitis, pancreatitis, and splenic abscess. (11531326)
2001
41
In vivo drug resistance during treatment for typhoid fever: a case report. (11961854)
2001
42
Ceftriaxone therapy in ciprofloxacin treatment failure typhoid fever in children. (11816954)
2001
43
Correlates of psychiatric morbidity in typhoid fever in a Nigerian general hospital setting. (11427249)
2001
44
Persistent fever in a case of typhoid--an unusual cause of neuroleptic malignant syndrome. (11837781)
2001
45
Massive hemorrhage from colonic ulcers in typhoid fever. (11305506)
2001
46
Rapid diagnosis of typhoid fever. (10773905)
1998
47
Diagnosis of typhoid fever: detection of Salmonella typhi porins-specific antibodies by inhibition ELISA. (8222322)
1993
48
Athetosis in typhoid fever. (3701678)
1986
49
Intestinal perforation in typhoid fever: a historical and state-of-the-art review. (3890098)
1985
50
Periostitis in Typhoid Fever. (20751254)
1885

Genetic Variations for Typhoid Fever

Expression for genes affiliated with Typhoid Fever

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Typhoid Fever

Search GEO for disease gene expression data for Typhoid Fever.

Pathways for genes affiliated with Typhoid Fever

Sources:
38NCBI BioSystems Database, 53R&D Systems, 52QIAGEN
See all sources

Pathways related to Typhoid Fever according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.2IL12B, IFNGR1, TLR5
2
Hide members
10.1IL12B, LTB, TNFRSF9, TLR5

Compounds for genes affiliated with Typhoid Fever

Sources:
45Novoseek, 11DrugBank, 50PharmGKB, 29IUPHAR, 24HMDB
See all sources

Compounds related to Typhoid Fever according to GeneCards/GeneDecks:

(show all 35)
idCompoundScoreTop Affiliating Genes
1ertapenem4510.7LACTB, VDAC1
2moxalactam4510.7LACTB, VDAC1
3aztreonam4510.7VDAC1, LACTB
4cefoxitin4510.7VDAC1, LACTB
5tazobactam4510.6VDAC1, LACTB
6clindamycin45 1111.6LACTB, G6PD
7cefuroxime45 1111.6OMP, LACTB
8meropenem4510.6VDAC1, LACTB
9cephalosporin4510.6VDAC1, LACTB
10nitrofurantoin45 50 1112.6G6PD, LACTB
11imipenem4510.6LACTB, VDAC1, OMP
12cefepime45 1111.6VDAC1, LACTB
13ceftazidime45 1111.6LACTB, VDAC1, OMP
14beta-lactam4510.6LACTB, VDAC1
15nalidixic acid45 50 1112.6LACTB, G6PD
16ceftriaxone45 1111.6LACTB, VDAC1, G6PD
17ciprofloxacin45 1111.6OMP, VDAC1, LACTB
18cefazolin45 1111.6G6PD, LACTB
19aminoglycosides4510.6LACTB, VDAC1
20cefotaxime45 1111.5LACTB, VDAC1
21trimethoprim45 50 1112.5G6PD, LACTB
22peptidoglycan45 2911.5TLR5, OMP, VDAC1, IL12B
23norfloxacin45 50 1112.5LACTB, G6PD
24galactose-1-phosphate4510.5GALE, G6PD
25glyceraldehyde 3-phosphate4510.4G6PD, RHD, ANXA6, VDAC1
26ampicillin45 1111.4LACTB, VDAC1
27mefloquine45 1111.4RHD, G6PD
28iron45 2411.4IFNGR1, RHD, OMP, VDAC1, SLC11A1
29nad+4510.4G6PD, GALE, VDAC1
30polysaccharide4510.3GALE, RHD, OMP, VDAC1
31amoxicillin45 50 1112.3VDAC1, LACTB
32sulfamethoxazole45 50 1112.3LACTB, G6PD
33sodium dodecylsulfate4510.2IL12B, VDAC1, RHD
34penicillin4510.2VDAC1, LACTB
35dids45 2911.0VDAC1, RHD

GO Terms for genes affiliated with Typhoid Fever

Sources:
16Gene Ontology
See all sources

Biological processes related to Typhoid Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1defense response to Gram-negative bacteriumGO:05082910.3SLC11A1, IL12B
2positive regulation of T-helper 1 type immune responseGO:00282710.2SLC11A1, IL12B
3defense response to protozoanGO:04283210.0SLC11A1, IL12B

Molecular functions related to Typhoid Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine bindingGO:01995510.3TNFRSF9, IFNGR1

Products for genes affiliated with Typhoid Fever

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Typhoid Fever

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet