MCID: TYP007
MIFTS: 61

Typhoid Fever malady

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Typhoid Fever

Aliases & Descriptions for Typhoid Fever:

Name: Typhoid Fever 12 50 56 52 3 42 14 69
Typhoid 12 50 56 14
Typhoidal Salmonellosis 56
Enteric Fever 50

Characteristics:

Orphanet epidemiological data:

56
typhoid
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe),>1/1000 (South East Asia),1-5/10000 (Latin America),1-5/10000 (Africa),1-9/1000000 (North America),1-5/10000 (Oceania),1-9/1000000 (France); Age of onset: All ages; Age of death: adolescent,late childhood;

Classifications:

Orphanet: 56  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:13258
ICD10 33 A01.0 A01.00
ICD9CM 35 002.0
MeSH 42 D014435
NCIt 47 C35089
Orphanet 56 ORPHA99745
ICD10 via Orphanet 34 A01.0
UMLS 69 C0041466

Summaries for Typhoid Fever

Disease Ontology : 12 A primary bacterial infectious disease that is a communicable systemic illness, has material basis in Salmonella enterica subsp enterica serovar Typhi, which is transmitted_by ingestion of food or water contaminated with the feces of an infected person. The infection has symptom fever, has symptom diarrhea, has symptom prostration, has symptom headache, has symptom splenomegaly, has symptom liver enlargement, has symptom eruption of rose-colored spots, and has symptom leukopenia.

MalaCards based summary : Typhoid Fever, also known as typhoid, is related to hepatitis and intussusception, and has symptoms including fever, diarrhea and prostration. An important gene associated with Typhoid Fever is SLC11A1 (Solute Carrier Family 11 Member 1), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Azithromycin and Cefixime have been mentioned in the context of this disorder. Affiliated tissues include testes, skin and liver, and related phenotypes are homeostasis/metabolism and hematopoietic system

CDC : 3 Typhoid fever is a life-threatening illness caused by the bacterium Salmonella Typhi. An estimated 5,700 cases occur each year in the United States.  Most cases (up to 75%) are acquired while traveling internationally. Typhoid fever is still common in the developing world, where it affects about 21.5 million people each year.

Wikipedia : 71 Typhoid fever, also known simply as typhoid, is a bacterial infection due to Salmonella typhi that... more...

Related Diseases for Typhoid Fever

Diseases related to Typhoid Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 335)
id Related Disease Score Top Affiliating Genes
1 hepatitis 30.9 IFNG IL6 TNF
2 intussusception 30.1 IL1B TNF
3 hemolytic-uremic syndrome 29.7 ALB IFNG TNF
4 dengue hemorrhagic fever 29.7 IFNG SLC11A1 TLR4 TNF
5 typhoidal tularemia 12.0
6 salmonellosis 11.4
7 paratyphoid fever 11.4
8 intravascular papillary endothelial hyperplasia 10.3 IFNG IFNGR1
9 vps11-related autosomal recessive hypomyelinating leukodystrophy 10.3 IL6 TNF
10 congenital dyserythropoietic anemia 10.3 ALB TNF
11 microcephaly 10.3 IFNG IFNGR1 TNF
12 esophagus lymphoma 10.3 IFNG IL6 TNF
13 clostridium difficile colitis 10.3 IFNG IL6 TNF
14 cyclosporiasis 10.3 IFNG IL6 TNF
15 conduct disorder 10.2 IFNG IL6 TNF
16 pancreatic signet ring cell adenocarcinoma 10.2 IFNG IL6 TNF
17 erb-duchenne and dejerine-klumpke palsies 10.2 IFNG IL6 TNF
18 anal atresia, hypospadias, and penoscrotal inversion 10.2 IFNG IFNGR1 SLC11A1
19 red cell phospholipid defect with hemolysis 10.2 IFNG IL6 TNF
20 orbital osteomyelitis 10.2 IFNG IL6 TNF
21 stocco dos santos syndrome 10.2 IFNG IL1B TNF
22 abnormal retinal correspondence 10.2 IFNG TLR4 TNF
23 disease of mental health 10.2 IFNG IL6 TNF
24 aortic coarctation 10.2 IL6 TLR4 TNF
25 amyotrophic lateral sclerosis type 14 10.2 IFNG IL1B TNF
26 burns 10.2 IFNG IL6 TNF
27 unilateral multicystic dysplastic kidney 10.2 CRP IL6 TNF
28 swine influenza 10.2 CRP IL6 TNF
29 senile reticular retinal degeneration 10.2 IFNG IL1B TNF
30 strawberry gallbladder 10.2 CRP IFNG TNF
31 coloboma of iris 10.2 CRP IL6
32 joint disorders 10.2 CRP IL6 TNF
33 cataract, total congenital 10.2 CRP IFNG IL6
34 tau syndrome 10.2 IL1B TNF
35 cicatricial lagophthalmos 10.2 CRP IL6 TNF
36 hemangioma of spleen 10.2 CRP IFNG IL6
37 anal paget's disease 10.2 IL1B IL6 TNF
38 hepatitis a 10.2
39 bipolar i disorder 10.2 IL1B IL6 TNF
40 tinea capitis 10.2 IL1B IL6 TNF
41 measles 10.2 IL1B IL6 TNF
42 multiple mitochondrial dysfunctions syndrome 10.2 CRP IFNG IL6
43 dextrocardia 10.2 IL1B IL6 TNF
44 oral cavity carcinoma in situ 10.2 IFNG IL1B SLC11A1
45 autoimmune disease of central nervous system 10.2 CRP IL6 TNF
46 steroid dehydrogenase deficiency dental anomalies 10.2 IL1B IL6 TNF
47 benign deep fibrous histiocytoma 10.2 ALB IFNG TNF
48 acquired thrombocytopenia 10.2 IL1B IL6 TNF
49 gonococcal endophthalmia 10.2 IL1B IL6 TNF
50 mixed mineral dust pneumoconiosis 10.2 CRP IFNG IL6

Graphical network of the top 20 diseases related to Typhoid Fever:



Diseases related to Typhoid Fever

Symptoms & Phenotypes for Typhoid Fever

Symptoms:

12
  • fever
  • diarrhea
  • prostration
  • headache
  • splenomegaly
  • liver enlargement
  • eruption of rose-colored spots
  • leukopenia

Human phenotypes related to Typhoid Fever:

56 32 (show all 28)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 ataxia 56 32 Frequent (79-30%) HP:0001251
2 arthralgia 56 32 Frequent (79-30%) HP:0002829
3 constipation 56 32 Occasional (29-5%) HP:0002019
4 fatigue 56 32 Very frequent (99-80%) HP:0012378
5 myalgia 56 32 Frequent (79-30%) HP:0003326
6 fever 56 32 Very frequent (99-80%) HP:0001945
7 headache 56 32 Very frequent (99-80%) HP:0002315
8 tremor 56 32 Occasional (29-5%) HP:0001337
9 abdominal pain 56 32 Very frequent (99-80%) HP:0002027
10 diarrhea 56 32 Occasional (29-5%) HP:0002014
11 lethargy 56 32 Occasional (29-5%) HP:0001254
12 macule 56 32 Frequent (79-30%) HP:0012733
13 hyperreflexia 56 32 Frequent (79-30%) HP:0001347
14 encephalitis 56 32 Occasional (29-5%) HP:0002383
15 splenomegaly 56 32 Frequent (79-30%) HP:0001744
16 hepatomegaly 56 32 Frequent (79-30%) HP:0002240
17 hypertonia 56 32 Frequent (79-30%) HP:0001276
18 venous thrombosis 56 32 Occasional (29-5%) HP:0004936
19 coma 56 32 Occasional (29-5%) HP:0001259
20 gastrointestinal hemorrhage 56 32 Occasional (29-5%) HP:0002239
21 epistaxis 56 32 Occasional (29-5%) HP:0000421
22 skin rash 56 32 Frequent (79-30%) HP:0000988
23 cough 56 32 Occasional (29-5%) HP:0012735
24 insomnia 56 32 Very frequent (99-80%) HP:0100785
25 cardiac arrest 56 32 Occasional (29-5%) HP:0001695
26 arrhythmia 56 Frequent (79-30%)
27 interstitial pulmonary disease 56 Occasional (29-5%)
28 interstitial pulmonary abnormality 32 HP:0006530

MGI Mouse Phenotypes related to Typhoid Fever:

44 (show all 13)
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.28 CASP1 CFTR CRP IFNG IFNGR1 IL1B
2 hematopoietic system MP:0005397 10.23 CASP1 CFTR IFNG IFNGR1 IL1B IL6
3 cardiovascular system MP:0005385 10.21 CASP1 CRP IFNG IFNGR1 IL1B IL6
4 digestive/alimentary MP:0005381 10.19 ALB CASP1 CFTR IFNG IFNGR1 IL6
5 behavior/neurological MP:0005386 10.18 CFTR IFNG IFNGR1 IL6 LTA OMP
6 immune system MP:0005387 10.18 CASP1 CFTR CRP IFNG IFNGR1 IL1B
7 endocrine/exocrine gland MP:0005379 10.13 ALB CASP1 CFTR IFNG IFNGR1 IL6
8 mortality/aging MP:0010768 10.07 CFTR IFNG IFNGR1 IL1B IL6 LTA
9 liver/biliary system MP:0005370 9.97 TLR5 TNF ALB CFTR IFNG IFNGR1
10 integument MP:0010771 9.91 IFNG IFNGR1 IL1B IL6 TLR4 TNF
11 neoplasm MP:0002006 9.81 ALB CASP1 IFNG IFNGR1 IL1B IL6
12 nervous system MP:0003631 9.61 CASP1 IFNG IFNGR1 IL1B IL6 LTA
13 respiratory system MP:0005388 9.23 TNF CFTR IFNG IL6 LTA OMP

Drugs & Therapeutics for Typhoid Fever

Drugs for Typhoid Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 48)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azithromycin Approved Phase 4,Phase 3 83905-01-5 55185 53477736 447043
2
Cefixime Approved Phase 4 79350-37-1 54362 5362065
3
Ceftriaxone Approved Phase 4 73384-59-5 5479530 5361919
4
Gatifloxacin Approved, Investigational Phase 4 112811-59-3 5379
5 Anti-Bacterial Agents Phase 4,Phase 3
6 Antibiotics, Antitubercular Phase 4
7 Anti-Infective Agents Phase 4,Phase 3,Phase 1,Phase 2
8 Antitubercular Agents Phase 4
9 Vaccines Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
10 Fluoroquinolones Phase 4
11 Nucleic Acid Synthesis Inhibitors Phase 4
12 Topoisomerase Inhibitors Phase 4
13
Sulfamethoxazole Approved Phase 3 723-46-6 5329
14
Trimethoprim Approved, Vet_approved Phase 3 738-70-5 5578
15
Lactitol Phase 3,Phase 2 585-86-4 3871
16 Antiparasitic Agents Phase 3,Phase 1,Phase 2
17 Antiprotozoal Agents Phase 3,Phase 1,Phase 2
18 Antimalarials Phase 3
19 Renal Agents Phase 3
20 Trimethoprim, Sulfamethoxazole Drug Combination Phase 3
21
Albendazole Approved, Vet_approved Phase 1, Phase 2 54965-21-8 2082
22
Metronidazole Approved Phase 1, Phase 2 443-48-1 4173
23
Zinc Approved Phase 1, Phase 2 7440-66-6 32051 23994
24 Zinc sulfate Approved Phase 1, Phase 2 7733-02-0
25
Formaldehyde Approved, Vet_approved Phase 2 50-00-0 712
26
Vitamin A Approved, Nutraceutical, Vet_approved Phase 2 11103-57-4, 68-26-8 445354
27 Antibodies Phase 2
28 Immunoglobulins Phase 2
29 Retinol palmitate Phase 2
30 Pharmaceutical Solutions Phase 1, Phase 2,Early Phase 1
31 Anthelmintics Phase 1, Phase 2
32 Antimitotic Agents Phase 1, Phase 2
33 Astringents Phase 1, Phase 2
34 Dermatologic Agents Phase 1, Phase 2
35 Micronutrients Phase 1, Phase 2
36 Secnidazole Phase 1, Phase 2
37 Trace Elements Phase 1, Phase 2
38 Heptavalent Pneumococcal Conjugate Vaccine Phase 2,Phase 1
39 Liver Extracts Phase 1, Phase 2
40 retinol Nutraceutical Phase 2
41 Lecithin Nutraceutical Phase 1, Phase 2
42 Soy Bean Nutraceutical Phase 1, Phase 2
43
Loperamide Approved Phase 1 53179-11-6 3955
44 Antidiarrheals Phase 1
45 Gastrointestinal Agents Phase 1
46
Pectin Phase 1 9000-69-5 441476
47 BCG Vaccine
48 Cantharidin Early Phase 1 56-25-7

Interventional clinical trials:

(show all 50)
id Name Status NCT ID Phase
1 Typhoid Fever: Combined vs. Single Antibiotic Therapy Unknown status NCT02224040 Phase 4
2 Evaluation of the Vi Polysaccharide Vaccine Against Typhoid Fever Completed NCT00125008 Phase 4
3 Introduction of the Vi Polysaccharide Typhoid Vaccine in Hue City, Central Vietnam Completed NCT00131820 Phase 4
4 Typhoid Vi Vaccine Effectiveness in Hechi, Guangxi, China Completed NCT00131833 Phase 4
5 Combined Vi Vaccination and Health Education Program on the Burden of Typhoid in Childhood Completed NCT00125047 Phase 4
6 Gatifloxacin Versus Ceftriaxone in the Treatment of Enteric Fever Completed NCT01421693 Phase 4
7 Cross-reactive Immunity Elicited by Oral and Parenteral Typhoid Vaccines Recruiting NCT02121145 Phase 4
8 Study of a Single Dose of SP093 Typhoid Vi Polysaccharide Vaccine in Japanese Subjects Completed NCT01608815 Phase 3
9 Comparative Study in Healthy Adults Aged 18-50 Yrs Administered With Hepatyrix or Havrix+Typherix or Tiphim Vi, to Compare Reactogenicity & Immunogenicity Completed NCT00197249 Phase 3
10 A Phase 3b, Randomized, Open-Label Study to Evaluate the Safety and Immunogenicity of Select Travel Vaccines When Administered Concomitantly With MenACWY in Adults Completed NCT01466387 Phase 3
11 Improving Rotavirus Vaccine Immune Response Completed NCT01825109 Phase 3
12 Nepal Undifferentiated Febrile Illness Trial Recruiting NCT02773407 Phase 3
13 Dose Ranging Study to Determine the Safety, Reactogenicity and Immunogenicity of Typhoid Fever Vaccine (Ty800) in Healthy Adult Subjects Completed NCT00498654 Phase 2
14 Safety, Immunogenicity and Compatibility With DTP of a Typhoid Fever Vaccine in Infants Completed NCT00342628 Phase 2
15 Immunogenicity, Safety and Tolerability of the Typhoid Fever Vaccine Candidate M01ZH09 in Healthy Adults Completed NCT00679172 Phase 2
16 TY800 Dose Escalation (Typhoid) Completed NCT00269295 Phase 1, Phase 2
17 Studies of Immune Responses to Orally Administered Vaccines in Developing Country Completed NCT01019083 Phase 1, Phase 2
18 Safety and Immunogenicity of Vi-CRM197 Vaccine Against S. Typhi in Adults, Children, Older Infants and Infants Completed NCT01229176 Phase 2
19 Safety and Immunogenicity of Vi-CRM197 Vaccine Against S. Typhi in Children, Older Infants and Infants Completed NCT01437267 Phase 2
20 Extension Study of H01_04TP to Evaluate the Booster Response Induced by Vi-CRM197 in Adults Completed NCT01438996 Phase 2
21 Safety and Immunogenicity of Three Formulations of Vi-CRM197 Vaccine Against S. Typhi in Adults (18-40 Years Old) Completed NCT01193907 Phase 2
22 Study of ChimeriVax™ Tetravalent Dengue Vaccine in Healthy Subjects Completed NCT00875524 Phase 2
23 Safety and Efficacy Study of Mix Vaccine in Prostate Carcinoma Patient Completed NCT02338700 Phase 1, Phase 2
24 Safety and Efficacy Study of Mix Vaccine in Breast Carcinoma Patient Completed NCT02338804 Phase 1, Phase 2
25 Safety and Efficacy Study of Mix Vaccine in Hepatocyte Carcinoma Patient Completed NCT02338778 Phase 1, Phase 2
26 Safety and Efficacy Study of Mix Vaccine in Pancreatic Carcinoma Patient Completed NCT02338752 Phase 1, Phase 2
27 Understanding Typhoid Disease After Vaccination Active, not recruiting NCT01405521 Phase 2
28 Vaccines Against Salmonella Typhi Active, not recruiting NCT02324751 Phase 2
29 Vaccines and Dietary Oats in the Treatment of Ulcerative Colitis Terminated NCT00751933 Phase 2
30 CVD 909 Vi Prime Boost Study Completed NCT00326443 Phase 1
31 Salmonella Typhi Vi O-Acetyl Pectin-rEPA Conjugate Vaccine Completed NCT00277147 Phase 1
32 Safety and Immunogenicity of Vi-CRM197 Vaccine Against S. Typhi in Adult (18-40 Years Old) Completed NCT01123941 Phase 1
33 Influence of Dietary Nitrate on Vascular Dysfunction and Inflammation Recruiting NCT02715635 Phase 1
34 Safety and Immunogenicity of a Vi-DT Typhoid Conjugate Vaccine Not yet recruiting NCT02645032 Phase 1
35 Safety and Immunogenicity of Vi-DT Typhoid Conjugate Vaccine (Bio Farma) in Adults and Children (Phase I) Not yet recruiting NCT03109600 Phase 1
36 Investigating the Effects of Typhoid Vaccine on Sleep in Healthy Volunteers Completed NCT02628054
37 Long Term Protection by and Persistence of Vi Antibodies Induced by Vi-rEPA Conjugate Vaccines in Vietnamese Children Injected at 2-5 Years or at 5-8 Years of Age Completed NCT00386789
38 Phase 4 Study To Assess The Safety Of Vivotif At Different Release Titers Among Travelers Completed NCT02391909
39 Role of BCG as Booster Vaccination Completed NCT02175420
40 Exploratory Study on the Mood and Cytokine Levels in Female Healthy Participants and Major Depressive Disorder Patients Completed NCT01533285 Early Phase 1
41 Rapid Diagnostic Tests and Clinical/Laboratory Predictors of Tropical Diseases In Patients With Persistent Fever in Cambodia, Nepal, Democratic Republic of the Congo and Sudan (NIDIAG-Fever) Completed NCT01766830
42 Investigating Typhoid Fever Pathogenesis Recruiting NCT03067961
43 Global Genomic and Proteomic Profiling of African Children With Typhoid Fever Recruiting NCT02947295
44 Investigating Enteric Fever - Salmonella Typhi and Paratyphi Challenge Study Recruiting NCT02192008
45 Typhoid Vaccine in Testing Response to Immune Stress in Patients With Stage I-IIIA Breast Cancer Who Received Chemotherapy Recruiting NCT02415387
46 Causes of Fever in Bangladeshi Patients Recruiting NCT02339259
47 Understanding Paratyphoid Infection Active, not recruiting NCT02100397
48 Investigation of the Influence of Gender on Cardiovascular Function Active, not recruiting NCT01582321 Early Phase 1
49 Inflammation and Threat Sensitivity in PTSD Not yet recruiting NCT03048929 Early Phase 1
50 Impact of Immune Challenge on Triple Network Connectivity in Humans Not yet recruiting NCT02653235

Search NIH Clinical Center for Typhoid Fever

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: typhoid fever

Genetic Tests for Typhoid Fever

Anatomical Context for Typhoid Fever

MalaCards organs/tissues related to Typhoid Fever:

39
Testes, Skin, Liver, Bone, Bone Marrow, Colon, T Cells

Publications for Typhoid Fever

Articles related to Typhoid Fever:

(show top 50) (show all 649)
id Title Authors Year
1
Rhabdomyolysis Complicating Typhoid Fever in a Child and Review of the Literature. ( 28430751 )
2017
2
The impact of migration and antimicrobial resistance on the transmission dynamics of typhoid fever in Kathmandu, Nepal: A mathematical modelling study. ( 28475605 )
2017
3
Comparison of Molecular Detection Method (Nested Polymerase Chain Reaction) with Blood Culture and Paired Widal test for the Rapid Diagnosis of Typhoid Fever. ( 28260765 )
2017
4
Bilateral retinitis following typhoid fever. ( 28405476 )
2017
5
Importance of Salmonella Typhi-Responsive CD8+ T Cell Immunity in a Human Typhoid Fever Challenge Model. ( 28303138 )
2017
6
The burden of typhoid fever in low- and middle-income countries: A meta-regression approach. ( 28241011 )
2017
7
A large and persistent outbreak of typhoid fever caused by consuming contaminated water and street-vended beverages: Kampala, Uganda, January - June 2015. ( 28056940 )
2017
8
Blood culture-PCR to optimise typhoid fever diagnosis after controlled human infection identifies frequent asymptomatic cases and evidence of primary bacteraemia. ( 28130144 )
2017
9
Typhoid Fever on the Half Shell. ( 28207076 )
2017
10
Determination of free polysaccharide in Vi glycoconjugate vaccine against typhoid fever. ( 28282600 )
2017
11
Reproducible diagnostic metabolites in plasma from typhoid fever patients in Asia and Africa. ( 28483042 )
2017
12
Epidemiological characteristics and clinical treatment outcome of typhoid fever in Ningbo China, 2005-2014, PFGE results revealing great proportion of common transmission sources. ( 28367881 )
2017
13
The Molecular and Spatial Epidemiology of Typhoid Fever in Rural Cambodia. ( 27331909 )
2016
14
Revisiting typhoid fever surveillance in low and middle income countries: lessons from systematic literature review of population-based longitudinal studies. ( 26822522 )
2016
15
Correction: Environmental Transmission of Typhoid Fever in an Urban Slum. ( 26727367 )
2016
16
Typhoid fever: case report and literature review. ( 27392073 )
2016
17
Epidemiological investigation of an outbreak of typhoid fever in Jorhat town of Assam, India. ( 28256469 )
2016
18
A Comparative Evaluation of Different Diagnostic Modalities in the Diagnosis of Typhoid Fever Using a Composite Reference Standard: A Tertiary Hospital Based Study in Central India. ( 27891335 )
2016
19
The Typhoid Fever Surveillance in Africa Program (TSAP): Clinical, Diagnostic, and Epidemiological Methodologies. ( 26933028 )
2016
20
Development of a live attenuated bivalent oral vaccine against Shigella sonnei shigellosis and typhoid fever. ( 27803169 )
2016
21
Immune Thrombocytopenic Purpura in Typhoid Fever. ( 27771690 )
2016
22
Serodiagnosis of Acute Typhoid Fever in Nigerian Pediatric Cases by Detection of Serum IgA and IgG against Hemolysin E and Lipopolysaccharide. ( 27215295 )
2016
23
Pharyngeal Typhoid: A Rare Complication of Typhoid Fever. ( 27746454 )
2016
24
An Outbreak of Food-Borne Typhoid Fever Due to Salmonella enterica Serotype Typhi in Japan Reported for the First Time in 16 Years. ( 26621565 )
2016
25
Challenges and Opportunities for Typhoid Fever Control: A Call for Coordinated Action. ( 26933019 )
2016
26
GyrA ser83 and ParC trp106 Mutations in Salmonella enterica Serovar Typhi Isolated from Typhoid Fever Patients in Tertiary Care Hospital. ( 27630841 )
2016
27
Low and declining attack rates of imported typhoid fever in the Netherlands 1997-2014, in spite of a restricted vaccination policy. ( 27905890 )
2016
28
Severe thrombocytopenia in a child with typhoid fever: a case report. ( 27906062 )
2016
29
Salmonella Typhi-specific multifunctional CD8+ T cells play a dominant role in protection from typhoid fever in humans. ( 26928826 )
2016
30
Interferon-driven alterations of the host's amino acid metabolism in the pathogenesis of typhoid fever. ( 27217537 )
2016
31
Typhoid toxin provides a window into typhoid fever and the biology of Salmonella Typhi. ( 27222578 )
2016
32
Comparison of the Performance of the TPTest, Tubex, Typhidot and Widal Immunodiagnostic Assays and Blood Cultures in Detecting Patients with Typhoid Fever in Bangladesh, Including Using a Bayesian Latent Class Modeling Approach. ( 27058877 )
2016
33
Typhoid Fever in Children below 2A years of Age. ( 26817466 )
2016
34
Evaluation of medicine retail outlets for sale of typhoid fever vaccine among adults in two urban and rural settings in western Kenya: a proof-of-concept study. ( 27688043 )
2016
35
The emergence and outbreak of multidrug-resistant typhoid fever in China. ( 27329848 )
2016
36
Notes from the Field: Typhoid Fever Outbreak Associated with an Asymptomatic Carrier at a Restaurant - Weld County, Colorado, 2015. ( 27310090 )
2016
37
Frosted Branch Angiitis in a Patient with Typhoid Fever. ( 28010144 )
2016
38
Utilization of Healthcare in the Typhoid Fever Surveillance in Africa Program. ( 26933023 )
2016
39
Clinical and Haematological Manifestations of Typhoid Fever in Children in Eastern Turkey. ( 26901611 )
2016
40
Typhoid Fever, Below the Belt. ( 26894114 )
2016
41
Typhoid Fever in South Africa in an Endemic HIV Setting. ( 27780232 )
2016
42
What Have We Learned From the Typhoid Fever Surveillance in Africa Program? ( 26933014 )
2016
43
Typhoid fever in a Tertiary Hospital in Nigeria: Another look at the Widal agglutination test as a preferred option for diagnosis. ( 27397952 )
2016
44
Identification of Five Novel Salmonella Typhi-Specific Genes as Markers for Diagnosis of Typhoid Fever Using Single-Gene Target PCR Assays. ( 27975062 )
2016
45
The unrecognized burden of typhoid fever. ( 27797598 )
2016
46
Diagnosis of imported Ugandan typhoid fever based on local outbreak information: A case report. ( 27297635 )
2016
47
Detection of Salivary IgA Antibodies Against the HlyE Antigen as a Diagnosis of Typhoid Fever. ( 27504289 )
2016
48
Third Generation Cephalosporins for Typhoid Fever. ( 27603449 )
2016
49
A Qualitative Study Investigating Experiences, Perceptions, and Healthcare System Performance in Relation to the Surveillance of Typhoid Fever in Madagascar. ( 26933024 )
2016
50
Efficacy of rapid antibody typhi point Elisa test in the diagnosis of typhoid fever when nested PCR was taken as gold standard. ( 27728395 )
2016

Variations for Typhoid Fever

Expression for Typhoid Fever

Search GEO for disease gene expression data for Typhoid Fever.

Pathways for Typhoid Fever

Pathways related to Typhoid Fever according to GeneCards Suite gene sharing:

(show top 50) (show all 69)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
14.03 CASP1 CRP IFNG IFNGR1 IL1B IL6
2
Show member pathways
13.66 CASP1 IFNG IFNGR1 IL1B IL6 LTA
3
Show member pathways
13.37 CASP1 IFNG IFNGR1 IL1B IL6 LTA
4
Show member pathways
13.19 IFNG IFNGR1 IL1B TLR4 TLR5 TNF
5
Show member pathways
13.03 CASP1 CFTR IL1B IL6 TLR4 TLR5
6
Show member pathways
12.96 IFNG IFNGR1 IL1B IL6 TLR4 TLR5
7
Show member pathways
12.86 IFNG IL1B IL6 LTA TNF
8
Show member pathways
12.75 CASP1 IFNG IL1B IL6 TNF
9
Show member pathways
12.75 IL1B IL6 LTA TLR4 TLR5 TNF
10
Show member pathways
12.69 IFNG IFNGR1 IL1B LTA TNF
11
Show member pathways
12.67 CASP1 IL1B LTA TLR4 TLR5 TNF
12
Show member pathways
12.66 CASP1 IFNG IFNGR1 IL1B IL6 LTA
13
Show member pathways
12.57 IFNG IL1B IL6 TNF
14
Show member pathways
12.56 IFNG IFNGR1 IL1B IL6 TLR4 TLR5
15
Show member pathways
12.44 IFNG IL1B IL6 TNF
16
Show member pathways
12.36 ALB CRP IFNG IL1B IL6 TNF
17
Show member pathways
12.35 CFTR IFNG IL1B IL6 TLR5 TNF
18
Show member pathways
12.32 IFNG IFNGR1 IL1B TLR4 TNF
19
Show member pathways
12.29 IL6 TLR4 TLR5 TNF
20
Show member pathways
12.22 IFNG IL1B IL6 LTA TNF
21 12.22 IFNG IFNGR1 IL1B IL6 TLR4 TNF
22
Show member pathways
12.2 IFNG IFNGR1 IL1B IL6 TLR4 TNF
23 12.1 IFNG IFNGR1 IL1B TNF
24 12.1 IFNG IFNGR1 IL6 TLR4 TLR5 TNF
25 12.08 IFNG IL1B IL6 TLR4 TNF
26 12.02 IL1B IL6 LTA TNF
27 11.99 IFNG IL6 TNF
28 11.98 IFNG IFNGR1 IL6 TLR4
29
Show member pathways
11.98 IFNG IL1B IL6 TLR4 TLR5
30 11.97 IL1B IL6 TNF
31 11.95 IL1B LTA TLR4 TNF
32 11.94 IFNG IL1B IL6
33 11.94 IFNG IL1B IL6 TLR4 TNF
34
Show member pathways
11.93 CASP1 IFNG IFNGR1 IL1B
35 11.9 IL1B IL6 TNF
36 11.89 IL1B IL6 TNF
37 11.88 IFNG IL1B IL6 TLR4 TNF
38
Show member pathways
11.87 CFTR IL6 TLR4
39 11.87 IFNG IL1B LTA TNF
40 11.84 IFNG IL1B IL6 TNF
41 11.79 CASP1 IL1B IL6 TLR4 TNF
42
Show member pathways
11.78 CFTR IFNG IFNGR1 IL1B IL6 TLR4
43
Show member pathways
11.74 IFNG IL1B IL6 TNF
44 11.72 IFNG IFNGR1 IL6
45 11.7 IL6 LTA TLR4 TLR5 TNF
46 11.69 IL1B IL6 TNF
47
Show member pathways
11.63 IFNG IFNGR1 LTA TNF
48 11.63 CASP1 IFNG IFNGR1 IL1B IL6 TLR4
49 11.62 LTA TLR4 TNF
50 11.61 IFNG IL1B TLR4 TNF

GO Terms for Typhoid Fever

Cellular components related to Typhoid Fever according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.76 ALB CASP1 CRP IFNG IL1B IL6
2 external side of plasma membrane GO:0009897 9.26 IFNG IL6 TLR4 TNF
3 extracellular space GO:0005615 9.17 ALB CRP IFNG IL1B IL6 LTA

Biological processes related to Typhoid Fever according to GeneCards Suite gene sharing:

(show top 50) (show all 58)
id Name GO ID Score Top Affiliating Genes
1 defense response to bacterium GO:0042742 9.99 IFNG SLC11A1 TLR4 TLR5 TNF
2 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.96 CASP1 IL1B TLR4 TNF
3 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.93 IL1B IL6 TLR4 TNF
4 inflammatory response GO:0006954 9.91 CRP IL1B IL6 SLC11A1 TLR4 TLR5
5 response to virus GO:0009615 9.9 IFNG IFNGR1 TNF
6 activation of MAPK activity GO:0000187 9.89 IL1B TLR4 TNF
7 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.89 IL1B IL6 TNF
8 cellular response to mechanical stimulus GO:0071260 9.88 CASP1 IL1B TLR4 TLR5
9 cellular response to lipopolysaccharide GO:0071222 9.88 IFNG IL6 TLR4 TLR5 TNF
10 regulation of insulin secretion GO:0050796 9.86 IFNG IL1B TNF
11 positive regulation of JNK cascade GO:0046330 9.85 IL1B TLR4 TNF
12 positive regulation of T cell proliferation GO:0042102 9.85 IFNG IL1B IL6
13 defense response to Gram-positive bacterium GO:0050830 9.85 CRP IL6 LTA TNF
14 defense response to Gram-negative bacterium GO:0050829 9.84 IL6 SLC11A1 TLR4
15 humoral immune response GO:0006959 9.84 IFNG IL6 LTA TNF
16 lipopolysaccharide-mediated signaling pathway GO:0031663 9.8 IL1B TLR4 TNF
17 positive regulation of phagocytosis GO:0050766 9.8 IL1B SLC11A1 TNF
18 positive regulation of interleukin-6 production GO:0032755 9.8 IL1B IL6 TLR4 TNF
19 response to lipopolysaccharide GO:0032496 9.8 CASP1 IL1B IL6 LTA SLC11A1 TLR4
20 positive regulation of NF-kappaB import into nucleus GO:0042346 9.78 IL1B TLR4 TNF
21 defense response to protozoan GO:0042832 9.77 IFNG IL6 SLC11A1
22 positive regulation of chemokine production GO:0032722 9.76 IL6 TLR4 TNF
23 negative regulation of growth of symbiont in host GO:0044130 9.74 IFNG LTA TNF
24 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.73 IFNG IL1B TNF
25 response to bacterium GO:0009617 9.73 CASP1 IL6 SLC11A1 TLR4
26 negative regulation of lipid catabolic process GO:0050995 9.72 IL1B TNF
27 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.71 IL1B TNF
28 regulation of interferon-gamma-mediated signaling pathway GO:0060334 9.71 IFNG IFNGR1
29 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.71 IL1B TNF
30 regulation of cytokine secretion GO:0050707 9.71 TLR4 TLR5
31 positive regulation of protein import into nucleus, translocation GO:0033160 9.71 IFNG IL6
32 positive regulation of interleukin-8 production GO:0032757 9.71 IL1B TLR4 TLR5 TNF
33 membrane hyperpolarization GO:0060081 9.7 CASP1 CFTR
34 negative regulation of interleukin-17 production GO:0032700 9.7 IFNG TLR4
35 macrophage activation GO:0042116 9.7 SLC11A1 TLR4
36 positive regulation of chemokine biosynthetic process GO:0045080 9.7 IFNG IL1B TNF
37 positive regulation of gene expression GO:0010628 9.7 CRP IFNG IL1B IL6 SLC11A1 TLR4
38 positive regulation of interleukin-6 biosynthetic process GO:0045410 9.69 IFNG IL1B
39 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.69 TLR4 TNF
40 regulation of defense response to virus by host GO:0050691 9.69 IFNG IL1B
41 negative regulation of lipid storage GO:0010888 9.69 CRP IL6 TNF
42 positive regulation of MHC class II biosynthetic process GO:0045348 9.68 IFNG TLR4
43 regulation of establishment of endothelial barrier GO:1903140 9.68 IL1B TNF
44 positive regulation of interleukin-12 biosynthetic process GO:0045084 9.67 IFNG TLR4
45 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.67 IL6 TNF
46 positive regulation of fever generation GO:0031622 9.66 IL1B TNF
47 interleukin-1 beta production GO:0032611 9.65 CASP1 IL1B
48 sequestering of triglyceride GO:0030730 9.65 IL1B TNF
49 positive regulation of humoral immune response mediated by circulating immunoglobulin GO:0002925 9.64 LTA TNF
50 neutrophil apoptotic process GO:0001781 9.64 IFNG IL6

Molecular functions related to Typhoid Fever according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 IFNG IL1B IL6 LTA TNF
2 interleukin-1 receptor binding GO:0005149 8.96 IL1B TLR5

Sources for Typhoid Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
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44 MGI
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48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
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59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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