MCID: TYP007
MIFTS: 61

Typhoid Fever

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Typhoid Fever

MalaCards integrated aliases for Typhoid Fever:

Name: Typhoid Fever 12 50 56 52 3 42 14 69
Typhoid 12 50 56
Typhoidal Salmonellosis 56
Enteric Fever 50

Characteristics:

Orphanet epidemiological data:

56
typhoid
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe),>1/1000 (South East Asia),1-5/10000 (Latin America),1-5/10000 (Africa),1-9/1000000 (North America),1-5/10000 (Oceania),1-9/1000000 (France); Age of onset: All ages; Age of death: adolescent,late childhood;

Classifications:

Orphanet: 56  
Rare infectious diseases


Summaries for Typhoid Fever

Disease Ontology : 12 A primary bacterial infectious disease that is a communicable systemic illness, has material basis in Salmonella enterica subsp enterica serovar Typhi, which is transmitted_by ingestion of food or water contaminated with the feces of an infected person. The infection has symptom fever, has symptom diarrhea, has symptom prostration, has symptom headache, has symptom splenomegaly, has symptom liver enlargement, has symptom eruption of rose-colored spots, and has symptom leukopenia.

MalaCards based summary : Typhoid Fever, also known as typhoid, is related to dengue disease and hemophagocytic lymphohistiocytosis, and has symptoms including ataxia, diarrhea and tremor. An important gene associated with Typhoid Fever is SLC11A1 (Solute Carrier Family 11 Member 1), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Azithromycin and Cefixime have been mentioned in the context of this disorder. Affiliated tissues include testes, liver and skin, and related phenotypes are homeostasis/metabolism and hematopoietic system

CDC : 3 Typhoid fever is a life-threatening illness caused by the bacterium Salmonella Typhi. An estimated 5,700 cases occur each year in the United States.  Most cases (up to 75%) are acquired while traveling internationally. Typhoid fever is still common in the developing world, where it affects about 21.5 million people each year.

Wikipedia : 72 Typhoid fever, also known simply as typhoid, is a bacterial infection due to Salmonella typhi that... more...

Related Diseases for Typhoid Fever

Diseases related to Typhoid Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 357)
id Related Disease Score Top Affiliating Genes
1 dengue disease 31.8 IFNG SLC11A1 TLR4 TNF
2 hemophagocytic lymphohistiocytosis 30.6 IFNG IL6 TNF
3 systemic lupus erythematosus 28.0 ALB CRP IFNG IL6 LTA TLR5
4 malaria 25.5 ALB CASP1 CRP IFNG IFNGR1 IL1B
5 typhoidal tularemia 12.0
6 paratyphoid fever 11.4
7 salmonellosis 11.4
8 intracranial aneurysms multiple congenital anomaly 10.8 IFNG IFNGR1
9 smarca4-deficient sarcoma of thorax 10.8 IL6 TNF
10 autoimmune polyglandular syndrome type 3 10.8 IFNG TNF
11 congenital dyserythropoietic anemia 10.7 ALB TNF
12 aortic arch interruption 10.7 IL6 TNF
13 cutaneous leishmaniasis 10.7 IL6 TNF
14 bulbospinal polio 10.7 IFNG TLR4
15 mosaic trisomy 1 10.7 IFNG TNF
16 primary systemic mycosis 10.7 IFNG TNF
17 rickettsialpox 10.6 TLR4 TNF
18 hypospadias 10.6 IFNG IFNGR1 TNF
19 lymphocytic colitis 10.6 IFNG IL6 TNF
20 pasteurellosis 10.6 IFNG IL6 TNF
21 low compliance bladder 10.6 TLR4 TNF
22 cyclosporiasis 10.6 IFNG IL6 TNF
23 tabatznik syndrome 10.6 IL1B TNF
24 dysphagia 10.6 IFNG IL6 TNF
25 conduct disorder 10.6 IFNG IL6 TNF
26 reardon wilson cavanagh syndrome 10.6 IFNG IL6 TNF
27 collagenopathy type 2 alpha 1 10.6 CRP IL6
28 orbital osteomyelitis 10.6 IFNG IL6 TNF
29 disease of mental health 10.6 IFNG IL6 TNF
30 extrahepatic bile duct adenocarcinoma 10.6 IFNG IL6 TNF
31 heart sarcoma 10.6 IFNG IL6 TNF
32 burn scar 10.5 IFNG IL6 TNF
33 acute interstitial pneumonia 10.5 IFNG IL6 TNF
34 pulmonary hypertension 10.5 IL1B TNF
35 cutaneous fibrous histiocytoma 10.5 ALB IFNG TNF
36 antigen-peptide-transporter 2 deficiency 10.5 IL6 TLR4 TNF
37 crystal arthropathies 10.5 CRP IL6
38 oculomotor nerve paralysis 10.5 IL1B IL6
39 shoulder impingement syndrome 10.5 CRP IL6
40 neonatal jaundice 10.5 IFNG IL6 TNF
41 autoimmune thyroid disease 4 10.5 IFNG IFNGR1 TNF
42 common peroneal nerve lesion 10.5 IL1B IL6
43 sternal cleft 10.5 IFNG IL1B TNF
44 brachydactyly-distal symphalangism syndrome 10.5 CRP IL6
45 dyslexia 5 10.5 IL6 TNF
46 prothrombin thrombophilia 10.5 IL1B TLR4
47 louping ill 10.5 CRP IFNG TNF
48 amyotrophic lateral sclerosis type 10 10.5 IFNG IL1B TNF
49 epstein-barr virus hepatitis 10.5 CRP IL6 TNF
50 uterine corpus epithelioid leiomyosarcoma 10.5 IFNG IFNGR1 TNF

Graphical network of the top 20 diseases related to Typhoid Fever:



Diseases related to Typhoid Fever

Symptoms & Phenotypes for Typhoid Fever

Human phenotypes related to Typhoid Fever:

56 32 (show all 28)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 ataxia 56 32 frequent (33%) Frequent (79-30%) HP:0001251
2 diarrhea 56 32 occasional (7.5%) Occasional (29-5%) HP:0002014
3 tremor 56 32 occasional (7.5%) Occasional (29-5%) HP:0001337
4 hyperreflexia 56 32 frequent (33%) Frequent (79-30%) HP:0001347
5 headache 56 32 hallmark (90%) Very frequent (99-80%) HP:0002315
6 hepatomegaly 56 32 frequent (33%) Frequent (79-30%) HP:0002240
7 splenomegaly 56 32 frequent (33%) Frequent (79-30%) HP:0001744
8 hypertonia 56 32 frequent (33%) Frequent (79-30%) HP:0001276
9 lethargy 56 32 occasional (7.5%) Occasional (29-5%) HP:0001254
10 fatigue 56 32 hallmark (90%) Very frequent (99-80%) HP:0012378
11 coma 56 32 occasional (7.5%) Occasional (29-5%) HP:0001259
12 encephalitis 56 32 occasional (7.5%) Occasional (29-5%) HP:0002383
13 constipation 56 32 occasional (7.5%) Occasional (29-5%) HP:0002019
14 myalgia 56 32 frequent (33%) Frequent (79-30%) HP:0003326
15 epistaxis 56 32 occasional (7.5%) Occasional (29-5%) HP:0000421
16 fever 56 32 hallmark (90%) Very frequent (99-80%) HP:0001945
17 abdominal pain 56 32 hallmark (90%) Very frequent (99-80%) HP:0002027
18 venous thrombosis 56 32 occasional (7.5%) Occasional (29-5%) HP:0004936
19 cough 56 32 occasional (7.5%) Occasional (29-5%) HP:0012735
20 insomnia 56 32 hallmark (90%) Very frequent (99-80%) HP:0100785
21 skin rash 56 32 frequent (33%) Frequent (79-30%) HP:0000988
22 cardiac arrest 56 32 occasional (7.5%) Occasional (29-5%) HP:0001695
23 arthralgia 56 32 frequent (33%) Frequent (79-30%) HP:0002829
24 gastrointestinal hemorrhage 56 32 occasional (7.5%) Occasional (29-5%) HP:0002239
25 macule 56 32 frequent (33%) Frequent (79-30%) HP:0012733
26 arrhythmia 56 Frequent (79-30%)
27 interstitial pulmonary disease 56 Occasional (29-5%)
28 interstitial pulmonary abnormality 32 occasional (7.5%) HP:0006530

MGI Mouse Phenotypes related to Typhoid Fever:

44 (show all 12)
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.25 CRP IFNG IFNGR1 IL1B IL6 LTA
2 hematopoietic system MP:0005397 10.21 CASP1 CFTR IFNG IFNGR1 IL1B IL6
3 cardiovascular system MP:0005385 10.19 CASP1 CRP IFNG IFNGR1 IL1B IL6
4 digestive/alimentary MP:0005381 10.18 ALB CASP1 CFTR IFNG IFNGR1 IL6
5 behavior/neurological MP:0005386 10.16 CFTR IFNG IFNGR1 IL6 LTA OMP
6 immune system MP:0005387 10.15 CASP1 CFTR TNF CRP IFNG IFNGR1
7 endocrine/exocrine gland MP:0005379 10.11 ALB CASP1 CFTR IFNG IFNGR1 IL6
8 mortality/aging MP:0010768 10.07 ALB CASP1 CFTR IFNG IFNGR1 IL1B
9 liver/biliary system MP:0005370 9.97 TNF ALB CFTR IFNG IFNGR1 IL6
10 neoplasm MP:0002006 9.81 ALB CASP1 IFNG IFNGR1 IL1B IL6
11 nervous system MP:0003631 9.61 TLR4 TNF CASP1 IFNG IFNGR1 IL1B
12 respiratory system MP:0005388 9.23 TLR4 TLR5 TNF CFTR IFNG IL6

Drugs & Therapeutics for Typhoid Fever

Drugs for Typhoid Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 49)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azithromycin Approved Phase 4,Phase 3 83905-01-5 55185 53477736 447043
2
Cefixime Approved Phase 4 79350-37-1 54362 5362065
3
Ceftriaxone Approved Phase 4 73384-59-5 5479530 5361919
4
Gatifloxacin Approved, Investigational Phase 4 112811-59-3 5379
5 Anti-Bacterial Agents Phase 4,Phase 3
6 Antibiotics, Antitubercular Phase 4
7 Anti-Infective Agents Phase 4,Phase 3,Phase 1,Phase 2
8 Antitubercular Agents Phase 4
9 Vaccines Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
10 Fluoroquinolones Phase 4
11 Nucleic Acid Synthesis Inhibitors Phase 4
12 Topoisomerase Inhibitors Phase 4
13
Sulfamethoxazole Approved Phase 3 723-46-6 5329
14
Trimethoprim Approved, Vet_approved Phase 3 738-70-5 5578
15
Lactitol Investigational Phase 3,Phase 2 585-86-4 3871
16 Antiparasitic Agents Phase 3,Phase 1,Phase 2
17 Antiprotozoal Agents Phase 3,Phase 1,Phase 2
18 Antimalarials Phase 3
19 Renal Agents Phase 3
20 Trimethoprim, Sulfamethoxazole Drug Combination Phase 3
21
Albendazole Approved, Vet_approved Phase 1, Phase 2 54965-21-8 2082
22
Metronidazole Approved Phase 1, Phase 2 443-48-1 4173
23
Secnidazole Approved Phase 1, Phase 2 3366-95-8
24
Zinc Approved Phase 1, Phase 2 7440-66-6 32051 23994
25 Zinc sulfate Approved Phase 1, Phase 2 7733-02-0
26
Formaldehyde Approved, Vet_approved Phase 2 50-00-0 712
27
Vitamin A Approved, Nutraceutical, Vet_approved Phase 2 11103-57-4, 68-26-8 445354
28 Antibodies Phase 2
29 Immunoglobulins Phase 2
30 Retinol palmitate Phase 2
31 Pharmaceutical Solutions Phase 1, Phase 2,Early Phase 1
32 Anthelmintics Phase 1, Phase 2
33 Antimitotic Agents Phase 1, Phase 2
34 Astringents Phase 1, Phase 2
35 Dermatologic Agents Phase 1, Phase 2
36 Micronutrients Phase 1, Phase 2
37 Trace Elements Phase 1, Phase 2
38 Heptavalent Pneumococcal Conjugate Vaccine Phase 2,Phase 1
39 Liver Extracts Phase 1, Phase 2
40 retinol Nutraceutical Phase 2
41 Lecithin Nutraceutical Phase 1, Phase 2
42 Soy Bean Nutraceutical Phase 1, Phase 2
43
Loperamide Approved Phase 1 53179-11-6 3955
44
Pectin Approved, Vet_approved Phase 1 9000-69-5 441476
45 Antidiarrheals Phase 1
46 Gastrointestinal Agents Phase 1
47
Ethanol Approved 64-17-5 702
48 Cantharidin Investigational Early Phase 1 56-25-7
49
BCG vaccine Investigational

Interventional clinical trials:

(show top 50) (show all 53)

id Name Status NCT ID Phase Drugs
1 Typhoid Fever: Combined vs. Single Antibiotic Therapy Unknown status NCT02224040 Phase 4 ceftriaxone;ceftriaxone and azithromycin;azithromycin;azithromycin and cefixime
2 Evaluation of the Vi Polysaccharide Vaccine Against Typhoid Fever Completed NCT00125008 Phase 4
3 Introduction of the Vi Polysaccharide Typhoid Vaccine in Hue City, Central Vietnam Completed NCT00131820 Phase 4
4 Typhoid Vi Vaccine Effectiveness in Hechi, Guangxi, China Completed NCT00131833 Phase 4
5 Combined Vi Vaccination and Health Education Program on the Burden of Typhoid in Childhood Completed NCT00125047 Phase 4
6 Gatifloxacin Versus Ceftriaxone in the Treatment of Enteric Fever Completed NCT01421693 Phase 4 Ceftriaxone;Gatifloxacin
7 Cross-reactive Immunity Elicited by Oral and Parenteral Typhoid Vaccines Recruiting NCT02121145 Phase 4
8 Study of a Single Dose of SP093 Typhoid Vi Polysaccharide Vaccine in Japanese Subjects Completed NCT01608815 Phase 3
9 Comparative Study in Healthy Adults Aged 18-50 Yrs Administered With Hepatyrix or Havrix+Typherix or Tiphim Vi, to Compare Reactogenicity & Immunogenicity Completed NCT00197249 Phase 3
10 A Phase 3b, Randomized, Open-Label Study to Evaluate the Safety and Immunogenicity of Select Travel Vaccines When Administered Concomitantly With MenACWY in Adults Completed NCT01466387 Phase 3
11 Improving Rotavirus Vaccine Immune Response Completed NCT01825109 Phase 3
12 Nepal Undifferentiated Febrile Illness Trial Recruiting NCT02773407 Phase 3 Azithromycin;Co-trimoxazole
13 Clinical Efficacy of Typhoid Conjugate Vaccine (Vi-TCV) Among Children Age 9 Months Through 12 Years in Blantyre, Malawi Not yet recruiting NCT03299426 Phase 3
14 Dose Ranging Study to Determine the Safety, Reactogenicity and Immunogenicity of Typhoid Fever Vaccine (Ty800) in Healthy Adult Subjects Completed NCT00498654 Phase 2
15 Safety, Immunogenicity and Compatibility With DTP of a Typhoid Fever Vaccine in Infants Completed NCT00342628 Phase 2
16 Immunogenicity, Safety and Tolerability of the Typhoid Fever Vaccine Candidate M01ZH09 in Healthy Adults Completed NCT00679172 Phase 2
17 TY800 Dose Escalation (Typhoid) Completed NCT00269295 Phase 1, Phase 2 Placebo
18 Studies of Immune Responses to Orally Administered Vaccines in Developing Country Completed NCT01019083 Phase 1, Phase 2 Placebo;Placebo;Zinc Sulphate;Albendazole and Secnidazole
19 Safety and Immunogenicity of Vi-CRM197 Vaccine Against S. Typhi in Adults, Children, Older Infants and Infants Completed NCT01229176 Phase 2
20 Safety and Immunogenicity of Vi-CRM197 Vaccine Against S. Typhi in Children, Older Infants and Infants Completed NCT01437267 Phase 2
21 Extension Study of H01_04TP to Evaluate the Booster Response Induced by Vi-CRM197 in Adults Completed NCT01438996 Phase 2
22 Safety and Immunogenicity of Three Formulations of Vi-CRM197 Vaccine Against S. Typhi in Adults (18-40 Years Old) Completed NCT01193907 Phase 2
23 Study of ChimeriVax™ Tetravalent Dengue Vaccine in Healthy Subjects Completed NCT00875524 Phase 2
24 Safety and Efficacy Study of Mix Vaccine in Prostate Carcinoma Patient Completed NCT02338700 Phase 1, Phase 2
25 Safety and Efficacy Study of Mix Vaccine in Breast Carcinoma Patient Completed NCT02338804 Phase 1, Phase 2
26 Safety and Efficacy Study of Mix Vaccine in Hepatocyte Carcinoma Patient Completed NCT02338778 Phase 1, Phase 2
27 Safety and Efficacy Study of Mix Vaccine in Pancreatic Carcinoma Patient Completed NCT02338752 Phase 1, Phase 2
28 Understanding Typhoid Disease After Vaccination Active, not recruiting NCT01405521 Phase 2
29 Vaccines Against Salmonella Typhi Active, not recruiting NCT02324751 Phase 2
30 Vaccines and Dietary Oats in the Treatment of Ulcerative Colitis Terminated NCT00751933 Phase 2
31 CVD 909 Vi Prime Boost Study Completed NCT00326443 Phase 1 Placebo
32 Salmonella Typhi Vi O-Acetyl Pectin-rEPA Conjugate Vaccine Completed NCT00277147 Phase 1 BB IND 6989
33 Safety and Immunogenicity of Vi-CRM197 Vaccine Against S. Typhi in Adult (18-40 Years Old) Completed NCT01123941 Phase 1
34 Safety and Immunogenicity of Vi-DT Typhoid Conjugate Vaccine (Bio Farma) in Adults and Children (Phase I) Recruiting NCT03109600 Phase 1
35 Influence of Dietary Nitrate on Vascular Dysfunction and Inflammation Recruiting NCT02715635 Phase 1
36 Safety and Immunogenicity of a Vi-DT Typhoid Conjugate Vaccine Not yet recruiting NCT02645032 Phase 1
37 Investigating the Effects of Typhoid Vaccine on Sleep in Healthy Volunteers Completed NCT02628054
38 Long Term Protection by and Persistence of Vi Antibodies Induced by Vi-rEPA Conjugate Vaccines in Vietnamese Children Injected at 2-5 Years or at 5-8 Years of Age Completed NCT00386789
39 Phase 4 Study To Assess The Safety Of Vivotif At Different Release Titers Among Travelers Completed NCT02391909
40 Investigation of the Influence of Gender on Cardiovascular Function Completed NCT01582321 Early Phase 1 Cantharidin
41 Role of BCG as Booster Vaccination Completed NCT02175420
42 Exploratory Study on the Mood and Cytokine Levels in Female Healthy Participants and Major Depressive Disorder Patients Completed NCT01533285 Early Phase 1
43 Rapid Diagnostic Tests and Clinical/Laboratory Predictors of Tropical Diseases In Patients With Persistent Fever in Cambodia, Nepal, Democratic Republic of the Congo and Sudan (NIDIAG-Fever) Completed NCT01766830
44 Investigating Typhoid Fever Pathogenesis Recruiting NCT03067961
45 Global Genomic and Proteomic Profiling of African Children With Typhoid Fever Recruiting NCT02947295
46 Investigating Enteric Fever - Salmonella Typhi and Paratyphi Challenge Study Recruiting NCT02192008
47 Typhoid Vaccine in Testing Response to Immune Stress in Patients With Stage I-IIIA Breast Cancer Who Received Chemotherapy Recruiting NCT02415387
48 Causes of Fever in Bangladeshi Patients Recruiting NCT02339259
49 Understanding Paratyphoid Infection Active, not recruiting NCT02100397
50 Cognitive, Emotional, and Neural Responses to Acute Inflammation Not yet recruiting NCT03294564 Early Phase 1

Search NIH Clinical Center for Typhoid Fever

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: typhoid fever

Genetic Tests for Typhoid Fever

Anatomical Context for Typhoid Fever

MalaCards organs/tissues related to Typhoid Fever:

39
Testes, Liver, Skin, Bone, Prostate, Bone Marrow, Colon

Publications for Typhoid Fever

Articles related to Typhoid Fever:

(show top 50) (show all 660)
id Title Authors Year
1
Updated estimates of typhoid fever burden in sub-Saharan Africa. ( 28911760 )
2017
2
Epidemiological characteristics and clinical treatment outcome of typhoid fever in Ningbo China, 2005-2014, PFGE results revealing great proportion of common transmission sources. ( 28367881 )
2017
3
Review of current typhoid fever vaccines, cross-protection against paratyphoid fever, and the European guidelines. ( 28856924 )
2017
4
Rhabdomyolysis Complicating Typhoid Fever in a Child and Review of the Literature. ( 28430751 )
2017
5
Detection of typhoid fever by diatom-based optical biosensor. ( 28577141 )
2017
6
Reproducible diagnostic metabolites in plasma from typhoid fever patients in Asia and Africa. ( 28483042 )
2017
7
Determination of free polysaccharide in Vi glycoconjugate vaccine against typhoid fever. ( 28282600 )
2017
8
The burden of typhoid fever in low- and middle-income countries: A meta-regression approach. ( 28241011 )
2017
9
Comparison of Molecular Detection Method (Nested Polymerase Chain Reaction) with Blood Culture and Paired Widal test for the Rapid Diagnosis of Typhoid Fever. ( 28260765 )
2017
10
Typhoid Fever on the Half Shell. ( 28207076 )
2017
11
The impact of migration and antimicrobial resistance on the transmission dynamics of typhoid fever in Kathmandu, Nepal: A mathematical modelling study. ( 28475605 )
2017
12
A cross-sectional seroepidemiological survey of typhoid fever in Fiji. ( 28727726 )
2017
13
Expression of intra- and extracellular granzymes in patients with typhoid fever. ( 28749963 )
2017
14
Salivary Anti-50 kDa Antibodies as a Useful Biomarker for Diagnosis of Typhoid Fever. ( 28764158 )
2017
15
Bilateral retinitis following typhoid fever. ( 28405476 )
2017
16
A large and persistent outbreak of typhoid fever caused by consuming contaminated water and street-vended beverages: Kampala, Uganda, January - June 2015. ( 28056940 )
2017
17
Importance of Salmonella Typhi-Responsive CD8+ T Cell Immunity in a Human Typhoid Fever Challenge Model. ( 28303138 )
2017
18
Blood culture-PCR to optimise typhoid fever diagnosis after controlled human infection identifies frequent asymptomatic cases and evidence of primary bacteraemia. ( 28130144 )
2017
19
Human genetic variation in VAC14 regulates Salmonella invasion and typhoid fever through modulation of cholesterol. ( 28827342 )
2017
20
Modifiable risk factors for typhoid intestinal perforations during a large outbreak of typhoid fever, Kampala Uganda, 2015. ( 28946853 )
2017
21
Development of ELISAs for diagnosis of acute typhoid fever in Nigerian children. ( 28640809 )
2017
22
An evaluation of purified Salmonella Typhi protein antigens for the serological diagnosis of acute typhoid fever. ( 28551371 )
2017
23
Typhoid fever in a Tertiary Hospital in Nigeria: Another look at the Widal agglutination test as a preferred option for diagnosis. ( 27397952 )
2016
24
Notes from the Field: Typhoid Fever Outbreak Associated with an Asymptomatic Carrier at a Restaurant - Weld County, Colorado, 2015. ( 27310090 )
2016
25
GyrA ser83 and ParC trp106 Mutations in Salmonella enterica Serovar Typhi Isolated from Typhoid Fever Patients in Tertiary Care Hospital. ( 27630841 )
2016
26
Identification of Five Novel Salmonella Typhi-Specific Genes as Markers for Diagnosis of Typhoid Fever Using Single-Gene Target PCR Assays. ( 27975062 )
2016
27
Utilization of Healthcare in the Typhoid Fever Surveillance in Africa Program. ( 26933023 )
2016
28
Salmonella Typhi-specific multifunctional CD8+ T cells play a dominant role in protection from typhoid fever in humans. ( 26928826 )
2016
29
Typhoid Fever, Below the Belt. ( 26894114 )
2016
30
An Outbreak of Food-Borne Typhoid Fever Due to Salmonella enterica Serotype Typhi in Japan Reported for the First Time in 16 Years. ( 26621565 )
2016
31
Typhoid toxin provides a window into typhoid fever and the biology of Salmonella Typhi. ( 27222578 )
2016
32
Typhoid Fever in Children below 2A years of Age. ( 26817466 )
2016
33
A Qualitative Study Investigating Experiences, Perceptions, and Healthcare System Performance in Relation to the Surveillance of Typhoid Fever in Madagascar. ( 26933024 )
2016
34
Low and declining attack rates of imported typhoid fever in the Netherlands 1997-2014, in spite of a restricted vaccination policy. ( 27905890 )
2016
35
Evaluation of medicine retail outlets for sale of typhoid fever vaccine among adults in two urban and rural settings in western Kenya: a proof-of-concept study. ( 27688043 )
2016
36
The Molecular and Spatial Epidemiology of Typhoid Fever in Rural Cambodia. ( 27331909 )
2016
37
Third Generation Cephalosporins for Typhoid Fever. ( 27603449 )
2016
38
Typhoid Fever in South Africa in an Endemic HIV Setting. ( 27780232 )
2016
39
The unrecognized burden of typhoid fever. ( 27797598 )
2016
40
Typhoid fever: case report and literature review. ( 27392073 )
2016
41
Serodiagnosis of Acute Typhoid Fever in Nigerian Pediatric Cases by Detection of Serum IgA and IgG against Hemolysin E and Lipopolysaccharide. ( 27215295 )
2016
42
Comparison of the Performance of the TPTest, Tubex, Typhidot and Widal Immunodiagnostic Assays and Blood Cultures in Detecting Patients with Typhoid Fever in Bangladesh, Including Using a Bayesian Latent Class Modeling Approach. ( 27058877 )
2016
43
Severe thrombocytopenia in a child with typhoid fever: a case report. ( 27906062 )
2016
44
Revisiting typhoid fever surveillance in low and middle income countries: lessons from systematic literature review of population-based longitudinal studies. ( 26822522 )
2016
45
Detection of Salivary IgA Antibodies Against the HlyE Antigen as a Diagnosis of Typhoid Fever. ( 27504289 )
2016
46
A Comparative Evaluation of Different Diagnostic Modalities in the Diagnosis of Typhoid Fever Using a Composite Reference Standard: A Tertiary Hospital Based Study in Central India. ( 27891335 )
2016
47
Immune Thrombocytopenic Purpura in Typhoid Fever. ( 27771690 )
2016
48
The emergence and outbreak of multidrug-resistant typhoid fever in China. ( 27329848 )
2016
49
Pharyngeal Typhoid: A Rare Complication of Typhoid Fever. ( 27746454 )
2016
50
Epidemiological investigation of an outbreak of typhoid fever in Jorhat town of Assam, India. ( 28256469 )
2016

Variations for Typhoid Fever

Expression for Typhoid Fever

Search GEO for disease gene expression data for Typhoid Fever.

Pathways for Typhoid Fever

Pathways related to Typhoid Fever according to GeneCards Suite gene sharing:

(show top 50) (show all 66)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
14.03 CASP1 CRP IFNG IFNGR1 IL1B IL6
2
Show member pathways
13.65 CASP1 IFNG IFNGR1 IL1B IL6 LTA
3
Show member pathways
13.36 CASP1 IFNG IFNGR1 IL1B IL6 LTA
4
Show member pathways
13.19 IFNG IFNGR1 IL1B TLR4 TLR5 TNF
5
Show member pathways
13.02 CASP1 CFTR IL1B IL6 TLR4 TLR5
6
Show member pathways
12.9 IFNG IFNGR1 IL1B IL6 TLR4 TLR5
7
Show member pathways
12.86 IFNG IL1B IL6 LTA TNF
8
Show member pathways
12.75 CASP1 IFNG IL1B IL6 TNF
9
Show member pathways
12.75 IL1B IL6 LTA TLR4 TLR5 TNF
10
Show member pathways
12.69 IFNG IFNGR1 IL1B LTA TNF
11
Show member pathways
12.67 CASP1 IL1B LTA TLR4 TLR5 TNF
12
Show member pathways
12.66 CASP1 IFNG IFNGR1 IL1B IL6 LTA
13
Show member pathways
12.57 IFNG IL1B IL6 TNF
14
Show member pathways
12.56 IFNG IFNGR1 IL1B IL6 TLR4 TLR5
15
Show member pathways
12.43 IFNG IL1B IL6 TNF
16
Show member pathways
12.36 CFTR IFNG IL1B IL6 TLR5 TNF
17
Show member pathways
12.32 IFNG IFNGR1 IL1B TLR4 TNF
18
Show member pathways
12.23 IFNG IFNGR1 IL1B IL6 TLR4 TNF
19
Show member pathways
12.22 IFNG IL1B IL6 LTA TNF
20 12.22 IFNG IFNGR1 IL1B IL6 TLR4 TNF
21 12.13 IFNG IFNGR1 IL6 TLR4 TLR5 TNF
22 12.09 IFNG IFNGR1 IL1B TNF
23 12.08 IFNG IL1B IL6 TLR4 TNF
24 12.01 IL1B IL6 LTA TNF
25 11.98 IFNG IL6 TNF
26 11.97 IL1B IL6 TNF
27 11.97 IFNG IFNGR1 IL6 TLR4
28 11.95 IL1B LTA TLR4 TNF
29 11.94 IFNG IL1B IL6 TLR4 TNF
30
Show member pathways
11.94 IFNG IL1B IL6 TLR4 TLR5
31 11.93 IFNG IL1B IL6
32
Show member pathways
11.93 CASP1 IFNG IFNGR1 IL1B
33 11.9 IL1B IL6 TNF
34 11.89 IL1B IL6 TNF
35 11.88 IFNG IL1B IL6 TLR4 TNF
36
Show member pathways
11.87 CFTR IL6 TLR4
37 11.86 IFNG IL1B LTA TNF
38 11.83 IFNG IL1B IL6 TNF
39 11.79 CASP1 IL1B IL6 TLR4 TNF
40
Show member pathways
11.78 CFTR IFNG IFNGR1 IL1B IL6 TLR4
41
Show member pathways
11.74 IFNG IL1B IL6 TNF
42 11.69 IL1B IL6 TNF
43 11.65 IL6 LTA TLR4 TLR5 TNF
44
Show member pathways
11.63 IFNG IFNGR1 LTA TNF
45 11.63 CASP1 IFNG IFNGR1 IL1B IL6 TLR4
46 11.61 LTA TLR4 TNF
47 11.61 IFNG IL1B TLR4 TNF
48 11.58 IFNG IL6 TNF
49 11.58 IFNG IL1B IL6 TNF
50 11.56 IL1B IL6 TNF

GO Terms for Typhoid Fever

Cellular components related to Typhoid Fever according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.7 ALB CRP IFNG IL1B IL6 LTA
2 extracellular region GO:0005576 9.56 ALB CASP1 CRP IFNG IL1B IL6
3 external side of plasma membrane GO:0009897 8.92 IFNG IL6 TLR4 TNF

Biological processes related to Typhoid Fever according to GeneCards Suite gene sharing:

(show top 50) (show all 58)
id Name GO ID Score Top Affiliating Genes
1 defense response to bacterium GO:0042742 9.98 IFNG SLC11A1 TLR4 TLR5 TNF
2 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.96 CASP1 IL1B TLR4 TNF
3 inflammatory response GO:0006954 9.95 CRP IL1B IL6 SLC11A1 TLR4 TLR5
4 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.94 IL1B IL6 TLR4 TNF
5 positive regulation of gene expression GO:0010628 9.91 CRP IFNG IL1B IL6 SLC11A1 TLR4
6 response to virus GO:0009615 9.9 IFNG IFNGR1 TNF
7 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.9 IL1B IL6 TNF
8 defense response to Gram-positive bacterium GO:0050830 9.9 CRP IL6 LTA TNF
9 activation of MAPK activity GO:0000187 9.89 IL1B TLR4 TNF
10 defense response to Gram-negative bacterium GO:0050829 9.88 IL6 SLC11A1 TLR4
11 positive regulation of JNK cascade GO:0046330 9.87 IL1B TLR4 TNF
12 cellular response to mechanical stimulus GO:0071260 9.87 CASP1 IL1B TLR4 TLR5
13 regulation of insulin secretion GO:0050796 9.85 IFNG IL1B TNF
14 positive regulation of T cell proliferation GO:0042102 9.85 IFNG IL1B IL6
15 humoral immune response GO:0006959 9.84 IFNG IL6 LTA TNF
16 lipopolysaccharide-mediated signaling pathway GO:0031663 9.81 IL1B TLR4 TNF
17 positive regulation of phagocytosis GO:0050766 9.8 IL1B SLC11A1 TNF
18 positive regulation of interleukin-6 production GO:0032755 9.8 IL1B IL6 TLR4 TNF
19 response to lipopolysaccharide GO:0032496 9.8 CASP1 IL1B IL6 LTA SLC11A1 TLR4
20 defense response to protozoan GO:0042832 9.78 IFNG IL6 SLC11A1
21 positive regulation of NF-kappaB import into nucleus GO:0042346 9.77 IL1B TLR4 TNF
22 response to bacterium GO:0009617 9.76 CASP1 IL6 SLC11A1 TLR4
23 positive regulation of chemokine production GO:0032722 9.75 IL6 TLR4 TNF
24 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.73 IFNG IL1B TNF
25 positive regulation of interleukin-8 production GO:0032757 9.73 IL1B TLR4 TLR5 TNF
26 negative regulation of lipid catabolic process GO:0050995 9.72 IL1B TNF
27 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.72 IL1B TNF
28 negative regulation of growth of symbiont in host GO:0044130 9.72 IFNG LTA TNF
29 regulation of interferon-gamma-mediated signaling pathway GO:0060334 9.71 IFNG IFNGR1
30 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.71 IL1B TNF
31 regulation of cytokine secretion GO:0050707 9.71 TLR4 TLR5
32 positive regulation of protein import into nucleus, translocation GO:0033160 9.71 IFNG IL6
33 negative regulation of interleukin-17 production GO:0032700 9.7 IFNG TLR4
34 macrophage activation GO:0042116 9.7 SLC11A1 TLR4
35 membrane hyperpolarization GO:0060081 9.7 CASP1 CFTR
36 positive regulation of chemokine biosynthetic process GO:0045080 9.7 IFNG IL1B TNF
37 regulation of defense response to virus by host GO:0050691 9.69 IFNG IL1B
38 positive regulation of interleukin-6 biosynthetic process GO:0045410 9.69 IFNG IL1B
39 negative regulation of lipid storage GO:0010888 9.69 CRP IL6 TNF
40 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.68 TLR4 TNF
41 positive regulation of MHC class II biosynthetic process GO:0045348 9.68 IFNG TLR4
42 regulation of establishment of endothelial barrier GO:1903140 9.68 IL1B TNF
43 positive regulation of interleukin-12 biosynthetic process GO:0045084 9.67 IFNG TLR4
44 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.67 IL6 TNF
45 positive regulation of fever generation GO:0031622 9.66 IL1B TNF
46 sequestering of triglyceride GO:0030730 9.65 IL1B TNF
47 positive regulation of humoral immune response mediated by circulating immunoglobulin GO:0002925 9.65 LTA TNF
48 interleukin-1 beta production GO:0032611 9.65 CASP1 IL1B
49 neutrophil apoptotic process GO:0001781 9.64 IFNG IL6
50 positive regulation of chronic inflammatory response to antigenic stimulus GO:0002876 9.62 LTA TNF

Molecular functions related to Typhoid Fever according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 IFNG IL1B IL6 LTA TNF
2 interleukin-1 receptor binding GO:0005149 8.96 IL1B TLR5

Sources for Typhoid Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
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48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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