MCID: TYP007
MIFTS: 63

Typhoid Fever malady

Infectious diseases category

Summaries for Typhoid Fever

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A primary bacterial infectious disease that is a communicable systemic illness, has material basis in salmonella enterica subsp enterica serovar typhi, which is transmitted by ingestion of food or water contaminated with the feces of an infected person. the infection has symptom fever, has symptom diarrhea, has symptom prostration, has symptom headache, has symptom splenomegaly, has symptom liver enlargement, has symptom eruption of rose-colored spots, and has symptom leukopenia.

MalaCards: Typhoid Fever, also known as typhoid, is related to malaria and cholera, and has symptoms including acute diarrhea, intestinal perforation and insomnia. An important gene associated with Typhoid Fever is OMP (olfactory marker protein), and among its related pathways are IL27-mediated signaling events and TRAF Pathway. The drug ciprofloxacin and the compounds ertapenem and moxalactam have been mentioned in the context of this disorder. Affiliated tissues include testes, liver and bone, and related mouse phenotype hematopoietic system.

Wikipedia:63 Typhoid fever — also known simply as typhoid — is a common worldwide bacterial disease transmitted... more...

Aliases & Classifications for Typhoid Fever

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 56SNOMED-CT, 34MeSH, 27ICD9CM, 39NCIt, 26ICD10 via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Characteristics (Orphanet epidemiological data):

48
typhoid fever:
Inheritance: Sporadic; Age of onset: Variable; Age of death: Child / adolescent


Aliases & Descriptions:

typhoid fever 8 42 10 44 48 60
typhoid 8 42 48
paratyphoid fever 48 60
enteric fever 42 48
typhoidal salmonellosis 48
typhoid infection 8
fever: typhoid 8
enteric 8


External Ids:

Disease Ontology8 DOID:13258
MeSH34 D014435
ICD9CM27 002.0
NCIt39 C35089
ICD10 via Orphanet26 A01.0
ICD1025 A01.0

Related Diseases for Typhoid Fever

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Typhoid Fever via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 496)
idRelated DiseaseScoreTop Affiliating Genes
1malaria30.8IFNGR1, G6PD, RHD, IL12B, SLC11A1, TCN2
2cholera30.6LTB, OMP, VDAC1
3paratyphoid fever30.5HIST1H1D
4arthritis30.4LACTB, SLC11A1
5hepatitis b30.4RHD
6meningitis30.3LACTB, OMP
7pneumonia30.1TLR5, ANXA6, LACTB
8inflammatory bowel disease30.1TLR5
9gastroenteritis30.0LACTB
10cystic fibrosis30.0OMP, ANXA6, VDAC1, LACTB
11deficiency anemia30.0SLC11A1, RHD, TCN2, G6PD
12leukemia30.0RHD, LTB, IL12B, TCN2, LACTB
13chagas disease29.9TCN2
14influenza29.9LACTB, TLR5, OMP
15tuberculosis29.9LACTB, IL12B, VDAC1, IFNGR1, SLC11A1
16asthma29.6IL12B, SLC11A1
17cerebral malaria29.6IL12B, G6PD, TCN2
18sarcoidosis29.5SLC11A1, IL12B, IFNGR1
19hepatitis10.8
20hepatitis a10.7
21neuronitis10.6
22intestinal perforation10.6
23diarrhea10.5
24acalculous cholecystitis10.5
25cholecystitis10.5
26short bowel syndrome10.5
27crohn's disease10.5
28hirschsprung's disease10.4
29splenic abscess10.4
30nervous system disease10.4
31intestinal obstruction10.3
32pancreatitis10.3
33periostitis10.3
34viral hepatitis10.3
35shigellosis10.3
36myocarditis10.3
37typhus10.3
38burns10.3
39intestinal pseudo-obstruction10.3
40acute diarrhea10.3
41reactive arthritis10.3
42coccidiosis10.3
43duodenitis10.2
44esophagitis10.2
45protein-losing enteropathy10.2
46adenocarcinoma10.2
47syndromic diarrhea10.2
48acute pancreatitis10.2
49antiphospholipid syndrome10.2
50adult respiratory distress syndrome10.2

Graphical network of the top 20 diseases related to Typhoid Fever:



Diseases related to typhoid fever

Clinical Features for Typhoid Fever

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Sources:
48Orphanet
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Symptoms:

48 (show all 36)
  • acute diarrhea
  • intestinal perforation
  • insomnia
  • epistaxis/nose bleeding
  • eruption of rose-colored spots
  • epigastralgia/heartburn/gastric/duodenal ulcer/gastritis
  • fever
  • headache
  • diarrhea
  • leukopenia
  • prostration
  • liver enlargement
  • collapse/sudden death/cardiac arrest/cardiorespiratory arrest
  • facial pain/cephalalgia/migraine
  • venous thrombosis/phlebitis/thrombophlebitis
  • delirium/hallucination
  • splenomegaly
  • hepatomegaly/liver enlargement (excluding storage disease)
  • encephalitis
  • tremor
  • ataxia/incoordination/trouble of the equilibrium
  • constipation
  • hypereflexia
  • obnubilation/coma/lethargia/desorientation
  • asthenia/fatigue/weakness
  • fever/chilling
  • gastrointestinal bleeding/hemorrhage/hematemesis/melena/rectorrhagia
  • acute abdominal pain/colic
  • myalgia/muscular pain
  • interstitial/restrictive pneumopathy/restrictive respiratory syndrome
  • cough
  • macules
  • cutaneous rash
  • cardiac rhythm disorder/arrhythmia
  • articular/joint pain/arthralgia
  • hypertonia/spasticity/rigidity/stiffness

Drugs & Therapeutics for Typhoid Fever

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Typhoid Fever

Drug clinical trials:

Search ClinicalTrials for Typhoid Fever

Search NIH Clinical Center for Typhoid Fever

Search CenterWatch for Typhoid Fever

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Typhoid Fever

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Anatomical Context for Typhoid Fever

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32MalaCards
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MalaCards organs/tissues related to Typhoid Fever:

32
Testes, Liver, Bone, Bone marrow, Colon, Spleen, Thyroid, Whole blood, Small intestine, Ovary

Animal Models for Typhoid Fever or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Typhoid Fever:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053979.6SLC11A1, IL12B, LTB, HIST1H1D, RHD, G6PD

Publications for Typhoid Fever

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Sources:
50PubMed
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Articles related to Typhoid Fever:

(show top 50)    (show all 607)
idTitleAuthorsYear
1
Evaluation of the Diagnostic Accuracy of a Typhoid IgM Flow Assay for the Diagnosis of Typhoid Fever in Cambodian Children Using a Bayesian Latent Class Model Assuming an Imperfect Gold Standard. (24218407)
2014
2
Typhoid Fever in nineteenth-century Colombia: between medical geography and bacteriology. (24331213)
2014
3
Correction: The Application of the Grey Disaster Model to Forecast Epidemic Peaks of Typhoid and Paratyphoid Fever in China. (24039655)
2013
4
Utilization and accessibility of healthcare on Pemba Island, Tanzania: implications for health outcomes and disease surveillance for typhoid fever. (23208887)
2013
5
Epidemiology of Typhoid Fever in Iran during Last Five Decades from 1962-2011. (23513182)
2013
6
Host factors and typhoid fever-associated intestinal perforation in children in Nigeria. (22648130)
2012
7
Acute transverse myelitis: an unusual complication of typhoid fever. (22824669)
2012
8
Evaluation of salivary anti-Salmonella typhi lipopolysaccharide IgA ELISA for serodiagnosis of typhoid fever in children. (22215815)
2012
9
Study of Clinical Profile and Antibiotic Sensitivity Pattern in Culture-positive Typhoid Fever Cases. (23293441)
2012
10
Sensitivity and specificity of typhoid fever rapid antibody tests for laboratory diagnosis at two sub-Saharan African sites. (21897484)
2011
11
Fluoroquinolones for treating typhoid and paratyphoid fever (enteric fever). (21975746)
2011
12
Typhoid fever in rural communities of West Bengal, India--an age-wise perspective. (20495282)
2010
13
Typhoid fever with severe abdominal pain: diagnosis and clinical findings using abdomen ultrasonogram, hematology-cell analysis and the Widal test. (21045376)
2010
14
Complicated typhoid fever. (20848818)
2010
15
Rethinking typhoid fever vaccines: implications for travelers and people living in highly endemic areas. (19192128)
2009
16
Granulomatous inflammatory response in a case of typhoid fever. (19349729)
2009
17
Health care preferences for children with typhoid fever in two slum communities in Karachi, Pakistan. (19062704)
2008
18
Typhoid Fever in Italy, 2000-2006. (19745525)
2008
19
A study of typhoid fever in five Asian countries: disease burden and implications for controls. (18438514)
2008
20
Typhoid fever in sub-Saharan Africa: challenges of diagnosis and management of infections. (19745521)
2008
21
Acute pancreatitis complicating typhoid fever in a 4-year-old girl. (18045312)
2007
22
Acalculous cholecystitis and abscess as a manifestation of typhoid fever. (17089115)
2007
23
Epidemiology and risk factors for endemic typhoid fever in Uzbekistan. (17596250)
2007
24
Trial participation and vaccine desirability for Vi polysaccharide typhoid fever vaccine in Hue City, Viet Nam. (17207145)
2007
25
DNA examination of ancient dental pulp incriminates typhoid fever as a probable cause of the Plague of Athens. (16412683)
2006
26
Typhoid fever in an 8-month-old infant. (17017411)
2006
27
Capsule-mediated immune evasion: a new hypothesis explaining aspects of typhoid fever pathogenesis. (16368953)
2006
28
Mass vaccination to control epidemic and endemic typhoid fever. (16989273)
2006
29
Typhoid and paratyphoid fever. (16125594)
2005
30
Nested PCR for diagnosis of typhoid fever. (16145179)
2005
31
Identification of typhoid fever and paratyphoid fever cases at presentation in outpatient clinics in Jakarta, Indonesia. (15837356)
2005
32
Policymakers' views regarding the introduction of new-generation vaccines against typhoid fever, shigellosis and cholera in Asia. (15780724)
2005
33
A look back: nursing care of typhoid fever: the pivotal role of nurses at the Children's Hospital of Philadelphia between 1895 and 1910: how the past informs the present. (15791088)
2005
34
Typhoid fever outbreak in Madaya Township, Mandalay Division, Myanmar, September 2000. (15217177)
2004
35
Typhoid fever in travelers: who should be targeted for prevention? (15307027)
2004
36
Correlation studies on Widal agglutination reaction and diagnosis of typhoid fever. (15272749)
2004
37
Use of vaccines for the prevention of typhoid fever. (14660833)
2003
38
Typhoid fever. (12647735)
2003
39
Diazo test in typhoid fever. (12657769)
2003
40
William Budd and typhoid fever. (12519817)
2003
41
Cytokine release by lipopolysaccharide-stimulated whole blood from patients with typhoid fever. (12134261)
2002
42
Typhoid glomerulonephritis in a child: a rare complication of typhoid fever. (12041566)
2001
43
Differentiation of typhoid fever from fulminant hepatic failure in patients presenting with jaundice and encephalopathy. (10807074)
2000
44
Outbreak of typhoid fever on the French Riviera. (10947223)
2000
45
Systemic lupus erythematosus-associated catastrophic antiphospholipid syndrome occurring after typhoid fever: a possible role of Salmonella lipopolysaccharide in the occurrence of diffuse vasculopathy-coagulopathy. (10323464)
1999
46
Lipopolysaccharide-independent radioimmunoprecipitation and identification of structural and in vivo induced immunogenic surface proteins of Salmonella typhi in typhoid fever. (8427032)
1993
47
Orchitis--an unusual complication of typhoid fever. (2632524)
1989
48
Typhoid fever with vulvovaginitis. (13599478)
1958
49
Typhoid and paratyphoid fever in immunized subjects. (18147216)
1949
50
Intestinal perforation complicating typhoid fever in children. (18866963)
1948

Genetic Variations for Typhoid Fever

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Expression for genes affiliated with Typhoid Fever

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Typhoid Fever

Search GEO for disease gene expression data for Typhoid Fever.

Pathways for genes affiliated with Typhoid Fever

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Sources:
37NCBI BioSystems Database, 52R&D Systems, 51QIAGEN
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Pathways related to Typhoid Fever according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.2IL12B, IFNGR1, TLR5
2
Hide members
10.1IL12B, LTB, TNFRSF9, TLR5

Compounds for genes affiliated with Typhoid Fever

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Sources:
44Novoseek, 11DrugBank, 49PharmGKB, 28IUPHAR, 24HMDB
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Compounds related to Typhoid Fever according to GeneCards/GeneDecks:

(show all 35)
idCompoundScoreTop Affiliating Genes
1ertapenem4410.7LACTB, VDAC1
2moxalactam4410.7LACTB, VDAC1
3aztreonam4410.7VDAC1, LACTB
4cefoxitin4410.7VDAC1, LACTB
5tazobactam4410.6VDAC1, LACTB
6clindamycin44 1111.6LACTB, G6PD
7cefuroxime44 1111.6OMP, LACTB
8meropenem4410.6VDAC1, LACTB
9cephalosporin4410.6VDAC1, LACTB
10nitrofurantoin44 49 1112.6G6PD, LACTB
11imipenem4410.6LACTB, VDAC1, OMP
12cefepime44 1111.6VDAC1, LACTB
13ceftazidime44 1111.6LACTB, VDAC1, OMP
14beta-lactam4410.6LACTB, VDAC1
15nalidixic acid44 49 1112.6LACTB, G6PD
16ceftriaxone44 1111.6LACTB, VDAC1, G6PD
17ciprofloxacin44 1111.6OMP, VDAC1, LACTB
18cefazolin44 1111.6G6PD, LACTB
19aminoglycosides4410.6LACTB, VDAC1
20cefotaxime44 1111.5LACTB, VDAC1
21trimethoprim44 49 1112.5G6PD, LACTB
22peptidoglycan44 2811.5TLR5, OMP, VDAC1, IL12B
23norfloxacin44 49 1112.5LACTB, G6PD
24galactose-1-phosphate4410.5GALE, G6PD
25glyceraldehyde 3-phosphate4410.4G6PD, RHD, ANXA6, VDAC1
26ampicillin44 1111.4LACTB, VDAC1
27mefloquine44 1111.4RHD, G6PD
28iron44 2411.4IFNGR1, RHD, OMP, VDAC1, SLC11A1
29nad+4410.4G6PD, GALE, VDAC1
30polysaccharide4410.3GALE, RHD, OMP, VDAC1
31amoxicillin44 49 1112.3VDAC1, LACTB
32sulfamethoxazole44 49 1112.3LACTB, G6PD
33sodium dodecylsulfate4410.2IL12B, VDAC1, RHD
34penicillin4410.2VDAC1, LACTB
35dids44 2811.0VDAC1, RHD

GO Terms for genes affiliated with Typhoid Fever

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16Gene Ontology
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Biological processes related to Typhoid Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1defense response to Gram-negative bacteriumGO:05082910.3SLC11A1, IL12B
2positive regulation of T-helper 1 type immune responseGO:00282710.2SLC11A1, IL12B
3defense response to protozoanGO:04283210.0SLC11A1, IL12B

Molecular functions related to Typhoid Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine bindingGO:01995510.3TNFRSF9, IFNGR1

Products for genes affiliated with Typhoid Fever

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Typhoid Fever

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet