MCID: TYP007
MIFTS: 61

Typhoid Fever malady

Rare diseases, Infectious diseases categories

Summaries for Typhoid Fever

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Disease Ontology:10 A primary bacterial infectious disease that is a communicable systemic illness, has material basis in salmonella enterica subsp enterica serovar typhi, which is transmitted by ingestion of food or water contaminated with the feces of an infected person. the infection has symptom fever, has symptom diarrhea, has symptom prostration, has symptom headache, has symptom splenomegaly, has symptom liver enlargement, has symptom eruption of rose-colored spots, and has symptom leukopenia.

MalaCards based summary: Typhoid Fever, also known as typhoid, is related to malaria and influenza, and has symptoms including hallucinations, abdominal pain and migraine. An important gene associated with Typhoid Fever is OMP (olfactory marker protein), and among its related pathways are Salmonella infection and Immune response IFN gamma signaling pathway. The drug ciprofloxacin and the compounds flagellin and peptidoglycan have been mentioned in the context of this disorder. Affiliated tissues include testes, liver and bone, and related mouse phenotypes are tumorigenesis and hematopoietic system.

Wikipedia:65 Typhoid fever ? also known simply as typhoid ? is a common worldwide bacterial disease transmitted by... more...

Aliases & Classifications for Typhoid Fever

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Sources:
49Orphanet, 62UMLS, 43NIH Rare Diseases, 10Disease Ontology, 12DISEASES, 45Novoseek, 4CDC, 57SNOMED-CT, 35MeSH, 29ICD9CM, 40NCIt, 28ICD10 via Orphanet, 27ICD10
See all sources

Typhoid Fever, Aliases & Descriptions:

Name: Typhoid Fever 10 43 12 45 49 4 62
Typhoid 10 43 49
Typhoid Infection 10 62
Paratyphoid Fever 49 62
Enteric Fever 43 49
 
Typhoidal Salmonellosis 49
Fever: Typhoid 10
Pontiac Fever 43
Enteric 10


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Infectious diseases


Characteristics (Orphanet epidemiological data):

49
typhoid fever:
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe),>1/1000 (South East Asia),1-5/10000 (Latin America),1-5/10000 (Africa),1-9/1000000 (North America),1-5/10000 (Oceania),1-9/1000000 (France); Age of onset: All ages; Age of death: adolescent,late childhood


External Ids:

Disease Ontology10 DOID:13258
MeSH35 D014435
ICD9CM29 002.0
NCIt40 C35089
Orphanet49 99745
ICD10 via Orphanet28 A01.0
ICD1027 A01.0

Related Diseases for Typhoid Fever

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Graphical network of the top 20 diseases related to Typhoid Fever:



Diseases related to typhoid fever

Symptoms for Typhoid Fever

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Symptoms:

 49 10 (show all 36)
  • epigastralgia/heartburn/gastric/duodenal ulcer/gastritis
  • acute abdominal pain/colic
  • facial pain/cephalalgia/migraine
  • insomnia
  • delirium/hallucination
  • fever/chilling
  • asthenia/fatigue/weakness
  • cutaneous rash
  • macules
  • hepatomegaly/liver enlargement (excluding storage disease)
  • splenomegaly
  • cardiac rhythm disorder/arrhythmia
  • ataxia/incoordination/trouble of the equilibrium
  • hypertonia/spasticity/rigidity/stiffness
  • hypereflexia
  • myalgia/muscular pain
  • articular/joint pain/arthralgia
  • acute diarrhea
  • constipation
  • gastrointestinal bleeding/hemorrhage/hematemesis/melena/rectorrhagia
  • intestinal perforation
  • cough
  • interstitial/restrictive pneumopathy/restrictive respiratory syndrome
  • collapse/sudden death/cardiac arrest/cardiorespiratory arrest
  • venous thrombosis/phlebitis/thrombophlebitis
  • encephalitis
  • tremor
  • obnubilation/coma/lethargia/desorientation
  • epistaxis/nose bleeding
  • fever
  • diarrhea
  • prostration
  • headache
  • liver enlargement
  • eruption of rose-colored spots
  • leukopenia

HPO human phenotypes related to Typhoid Fever:

(show all 25)
id Description Frequency HPO Source Accession
1 hallucinations hallmark (90%) HP:0000738
2 abdominal pain hallmark (90%) HP:0002027
3 migraine hallmark (90%) HP:0002076
4 abnormality of the gastric mucosa hallmark (90%) HP:0004295
5 abnormality of temperature regulation hallmark (90%) HP:0004370
6 insomnia hallmark (90%) HP:0100785
7 skin rash typical (50%) HP:0000988
8 hypermelanotic macule typical (50%) HP:0001034
9 hypertonia typical (50%) HP:0001276
10 hyperreflexia typical (50%) HP:0001347
11 splenomegaly typical (50%) HP:0001744
12 hepatomegaly typical (50%) HP:0002240
13 incoordination typical (50%) HP:0002311
14 arthralgia typical (50%) HP:0002829
15 myalgia typical (50%) HP:0003326
16 epistaxis occasional (7.5%) HP:0000421
17 tremor occasional (7.5%) HP:0001337
18 sudden cardiac death occasional (7.5%) HP:0001645
19 diarrhea occasional (7.5%) HP:0002014
20 constipation occasional (7.5%) HP:0002019
21 restrictive lung disease occasional (7.5%) HP:0002091
22 gastrointestinal hemorrhage occasional (7.5%) HP:0002239
23 encephalitis occasional (7.5%) HP:0002383
24 reduced consciousness/confusion occasional (7.5%) HP:0004372
25 thrombophlebitis occasional (7.5%) HP:0004418

Drugs & Therapeutics for Typhoid Fever

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Drug clinical trials:

Search ClinicalTrials for Typhoid Fever

Search NIH Clinical Center for Typhoid Fever

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Typhoid Fever

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Anatomical Context for Typhoid Fever

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MalaCards organs/tissues related to Typhoid Fever:

33
Testes, Liver, Bone, Lung, Skin, Bone marrow, Colon, Spleen, Thyroid, Whole blood, Small intestine, Ovary

Animal Models for Typhoid Fever or affiliated genes

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MGI Mouse Phenotypes related to Typhoid Fever:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.8SLC11A1, CASP1, IFNGR1
2MP:00053978.6SLC11A1, RHD, CASP1, IFNGR1

Publications for Typhoid Fever

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Articles related to Typhoid Fever:

(show top 50)    (show all 581)
idTitleAuthorsYear
1
Modeling malaria and typhoid fever co-infection dynamics. (25865934)
2015
2
Typhoid Fever in young children in bangladesh: clinical findings, antibiotic susceptibility pattern and immune responses. (25849611)
2015
3
Comparison between azithromycin and cefixime in the treatment of typhoid fever in children. (25178594)
2014
4
Out of Africa: Links Between Invasive Nontyphoidal Salmonella Disease, Typhoid Fever, and Malaria. (24336912)
2014
5
Cost of illness due to typhoid Fever in pemba, zanzibar, East Africa. (25395900)
2014
6
Mix-infection of S. Typhi and ParaTyphi A in Typhoid Fever and Chronic Typhoid Carriers: A Nested PCR Based Study in North India. (25584217)
2014
7
Multiple ileal perforations and concomitant cholecystitis with gall bladder gangrene as complication of typhoid fever. (25037301)
2014
8
Typhoid fever in Fiji: a reversible plague? (25066005)
2014
9
Typhoid fever in paediatric patients in Quetta, Balochistan, Pakistan. (24353661)
2013
10
Formative research and development of an evidence-based communication strategy: the introduction of Vi typhoid fever vaccine among school-aged children in Karachi, Pakistan. (23330632)
2013
11
Availability of clean tap water and medical services prevents the incidence of typhoid Fever. (24159533)
2013
12
Apropos "evaluation of serological diagnostic tests for typhoid Fever in papua new Guinea using a composite reference standard". (23359461)
2013
13
Host factors and typhoid fever-associated intestinal perforation in children in Nigeria. (22648130)
2012
14
Sensitivity and specificity of typhoid fever rapid antibody tests for laboratory diagnosis at two sub-Saharan African sites. (21897484)
2011
15
Safety, immunogenicity and dose ranging of a new Vi-CRMa88a88a88 conjugate vaccine against typhoid fever: randomized clinical testing in healthy adults. (21980445)
2011
16
Peptides representing the specific variable regions but not the full porin proteins can be useful for antibody based diagnosis of typhoid fever. (20941590)
2010
17
Treatment cost for typhoid fever at two hospitals in Kolkata, India. (20099755)
2009
18
Typhoid fever in southern Taiwan: a medical center experience. (19054916)
2008
19
Imported typhoid fever with hepatitis from Bangladesh: a case of delayed response to ceftriaxone? (19006514)
2008
20
Typhoid fever research in developing countries. (19745515)
2008
21
Polymorphisms in proinflammatory genes and susceptibility to typhoid fever and paratyphoid fever. (17477815)
2007
22
Plasma D-dimer levels in patients with typhoid fever. (18041311)
2007
23
Typhoid fever as a cause of opportunistic infection: case report. (16504150)
2006
24
Effects of pefloxacin in multi drug resistant typhoid fever. (16639809)
2006
25
Enhanced detection rate of typhoid fever in children in a periurban slum in Karachi, Pakistan using polymerase chain reaction technology. (16901852)
2006
26
Acute acalculous cholecystitis: A rare presentation of typhoid fever in adults. (16500779)
2006
27
Ultrasound in the diagnosis of typhoid fever. (16936362)
2006
28
Use of paired serum samples for serodiagnosis of typhoid fever. (16145168)
2005
29
A mass vaccination campaign targeting adults and children to prevent typhoid fever in Hechi; expanding the use of Vi polysaccharide vaccine in southeast China: a cluster-randomized trial. (15904514)
2005
30
Typhoid fever and viral hepatitis in a G6PD deficient individual. (16599045)
2005
31
Typhoid fever and typhoid hepatitis in Taiwan. (16274504)
2005
32
Rapid diagnosis of typhoid fever by enzyme-linked immunosorbent assay detection of Salmonella serotype typhi antigens in urine. (15031525)
2004
33
Osler on typhoid fever: differentiating typhoid from typhus and malaria. (15081508)
2004
34
Sexual transmission of typhoid fever: a multistate outbreak among men who have sex with men. (12830419)
2003
35
William Budd and typhoid fever. (12411628)
2002
36
An open randomized study of inactivated hepatitis A vaccine administered concomitantly with typhoid fever and yellow fever vaccines. (12044272)
2002
37
Typhoid fever and genetic polymorphisms at the natural resistance-associated macrophage protein 1. (11237848)
2001
38
Animal models of Salmonella infections: enteritis versus typhoid fever. (11755423)
2001
39
Blood culture confirmed typhoid fever in a provincial hospital in the Philippines. (11944712)
2001
40
An outbreak of typhoid fever, Xing-An County, People's Republic of China, 1999: estimation of the field effectiveness of Vi polysaccharide typhoid vaccine. (11372030)
2001
41
Differentiation of typhoid fever from fulminant hepatic failure in patients presenting with jaundice and encephalopathy. (10807074)
2000
42
Systemic lupus erythematosus-associated catastrophic antiphospholipid syndrome occurring after typhoid fever: a possible role of Salmonella lipopolysaccharide in the occurrence of diffuse vasculopathy-coagulopathy. (10323464)
1999
43
Typhoid fever presenting as infection-associated hemophagocytic syndrome: report of one case. (10910545)
1999
44
Rapid serologic diagnosis of pediatric typhoid fever in an endemic area: a prospective comparative evaluation of two dot-enzyme immunoassays and the Widal test. (10548305)
1999
45
Orchitis--an unusual complication of typhoid fever. (2632524)
1989
46
Intestinal perforation in typhoid fever: a historical and state-of-the-art review. (3890098)
1985
47
Toxic megacolon in typhoid fever. (4062466)
1985
48
Thyroxine, triiodothyronine and thyrotrophin levels in meningococcal meningitis, typhoid fever and other febrile conditions. (719910)
1978
49
Typhoid fever and intestinal perforation: Recovery with chloromycetin and dihydrostreptomycin. (14796868)
1950
50
Caries of Frontal Bone and Intracranial Abscess due to Bacillus typhosus Eleven Years after Attack of Typhoid Fever. (19976388)
1912

Variations for Typhoid Fever

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Expression for genes affiliated with Typhoid Fever

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Search GEO for disease gene expression data for Typhoid Fever.

Pathways for genes affiliated with Typhoid Fever

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Pathways related to Typhoid Fever according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5CASP1, IFNGR1
2
Show member pathways
IFN-gamma pathway38
9.5CASP1, IFNGR1

Compounds for genes affiliated with Typhoid Fever

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Sources:
45Novoseek, 30IUPHAR, 13DrugBank, 26HMDB, 51PharmGKB
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Compounds related to Typhoid Fever according to GeneCards/GeneDecks:

(show all 11)
idCompoundScoreTop Affiliating Genes
1flagellin45 3010.8CASP1, OMP
2peptidoglycan45 3010.7CASP1, OMP
3phosphatidylserine45 30 1311.4RHD, CASP1
4homocysteine45 2610.3RHD, TCN2
5galactose459.2GALE, RHD
6aspartate459.1CASP1, RHD, SLC11A1
7zinc45 2610.0OMP, CASP1, SLC11A1
8iron45 2610.0SLC11A1, RHD, IFNGR1, OMP
9polysaccharide458.9GALE, RHD, OMP
10oxygen45 269.8IFNGR1, CASP1, RHD, SLC11A1
11calcium45 51 26 1311.3SLC11A1, RHD, CASP1, OMP

GO Terms for genes affiliated with Typhoid Fever

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Biological processes related to Typhoid Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to lipopolysaccharideGO:00324969.2SLC11A1, CASP1
2signal transductionGO:00071659.2CASP1, IFNGR1, OMP

Products for genes affiliated with Typhoid Fever

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Sources for Typhoid Fever

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet