MCID: TYP007
MIFTS: 63

Typhoid Fever malady

Infectious diseases category

Summaries for Typhoid Fever

About this section
Sources:
8Disease Ontology, 63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Disease Ontology:8 A primary bacterial infectious disease that is a communicable systemic illness, has material basis in salmonella enterica subsp enterica serovar typhi, which is transmitted by ingestion of food or water contaminated with the feces of an infected person. the infection has symptom fever, has symptom diarrhea, has symptom prostration, has symptom headache, has symptom splenomegaly, has symptom liver enlargement, has symptom eruption of rose-colored spots, and has symptom leukopenia.

MalaCards: Typhoid Fever, also known as typhoid, is related to malaria and cholera, and has symptoms including epistaxis/nose bleeding, fever and obnubilation/coma/lethargia/desorientation. An important gene associated with Typhoid Fever is OMP (olfactory marker protein), and among its related pathways are IL27-mediated signaling events and TRAF Pathway. The drug ciprofloxacin and the compounds ertapenem and moxalactam have been mentioned in the context of this disorder. Affiliated tissues include testes, liver and bone, and related mouse phenotype hematopoietic system.

Wikipedia:63 Typhoid fever — also known simply as typhoid — is a common worldwide bacterial disease transmitted... more...

Aliases & Classifications for Typhoid Fever

About this section
Sources:
48Orphanet, 60UMLS, 8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 56SNOMED-CT, 34MeSH, 27ICD9CM, 39NCIt, 26ICD10 via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Characteristics (Orphanet epidemiological data):

48
typhoid fever:
Inheritance: Sporadic; Age of onset: Variable; Age of death: Child / adolescent


Aliases & Descriptions:

typhoid fever 8 42 10 44 48 60
typhoid 8 42 48
paratyphoid fever 48 60
enteric fever 42 48
typhoidal salmonellosis 48
typhoid infection 8
fever: typhoid 8
enteric 8


External Ids:

Disease Ontology8 DOID:13258
MeSH34 D014435
ICD9CM27 002.0
NCIt39 C35089
ICD10 via Orphanet26 A01.0
ICD1025 A01.0

Related Diseases for Typhoid Fever

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Typhoid Fever via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 496)
idRelated DiseaseScoreTop Affiliating Genes
1malaria30.8IFNGR1, G6PD, RHD, IL12B, SLC11A1, TCN2
2cholera30.6LTB, OMP, VDAC1
3paratyphoid fever30.5HIST1H1D
4arthritis30.4LACTB, SLC11A1
5hepatitis b30.4RHD
6meningitis30.3LACTB, OMP
7pneumonia30.1TLR5, ANXA6, LACTB
8inflammatory bowel disease30.1TLR5
9gastroenteritis30.0LACTB
10cystic fibrosis30.0OMP, ANXA6, VDAC1, LACTB
11deficiency anemia30.0SLC11A1, RHD, TCN2, G6PD
12leukemia30.0RHD, LTB, IL12B, TCN2, LACTB
13chagas disease29.9TCN2
14influenza29.9LACTB, TLR5, OMP
15tuberculosis29.9LACTB, IL12B, VDAC1, IFNGR1, SLC11A1
16asthma29.6IL12B, SLC11A1
17cerebral malaria29.6IL12B, G6PD, TCN2
18sarcoidosis29.5SLC11A1, IL12B, IFNGR1
19hepatitis10.8
20hepatitis a10.7
21neuronitis10.6
22intestinal perforation10.6
23diarrhea10.5
24acalculous cholecystitis10.5
25cholecystitis10.5
26short bowel syndrome10.5
27crohn's disease10.5
28hirschsprung's disease10.4
29splenic abscess10.4
30nervous system disease10.4
31intestinal obstruction10.3
32pancreatitis10.3
33periostitis10.3
34viral hepatitis10.3
35shigellosis10.3
36myocarditis10.3
37typhus10.3
38burns10.3
39intestinal pseudo-obstruction10.3
40acute diarrhea10.3
41reactive arthritis10.3
42coccidiosis10.3
43duodenitis10.2
44esophagitis10.2
45protein-losing enteropathy10.2
46adenocarcinoma10.2
47syndromic diarrhea10.2
48acute pancreatitis10.2
49antiphospholipid syndrome10.2
50adult respiratory distress syndrome10.2

Graphical network of the top 20 diseases related to Typhoid Fever:



Diseases related to typhoid fever

Clinical Features for Typhoid Fever

About this section
Sources:
48Orphanet
See all sources


Symptoms:

48 (show all 36)
  • epistaxis/nose bleeding
  • fever
  • obnubilation/coma/lethargia/desorientation
  • tremor
  • leukopenia
  • encephalitis
  • diarrhea
  • prostration
  • headache
  • splenomegaly
  • liver enlargement
  • eruption of rose-colored spots
  • fever/chilling
  • venous thrombosis/phlebitis/thrombophlebitis
  • collapse/sudden death/cardiac arrest/cardiorespiratory arrest
  • hepatomegaly/liver enlargement (excluding storage disease)
  • macules
  • cutaneous rash
  • asthenia/fatigue/weakness
  • delirium/hallucination
  • insomnia
  • facial pain/cephalalgia/migraine
  • acute abdominal pain/colic
  • cardiac rhythm disorder/arrhythmia
  • ataxia/incoordination/trouble of the equilibrium
  • hypertonia/spasticity/rigidity/stiffness
  • interstitial/restrictive pneumopathy/restrictive respiratory syndrome
  • cough
  • intestinal perforation
  • gastrointestinal bleeding/hemorrhage/hematemesis/melena/rectorrhagia
  • constipation
  • acute diarrhea
  • articular/joint pain/arthralgia
  • myalgia/muscular pain
  • hypereflexia
  • epigastralgia/heartburn/gastric/duodenal ulcer/gastritis

Drugs & Therapeutics for Typhoid Fever

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Typhoid Fever

Drug clinical trials:

Search ClinicalTrials for Typhoid Fever

Search NIH Clinical Center for Typhoid Fever

Search CenterWatch for Typhoid Fever

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Typhoid Fever

About this section

Anatomical Context for Typhoid Fever

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Typhoid Fever:

32
Testes, Liver, Bone, Bone marrow, Colon, Thyroid, Spleen, Small intestine, Ovary, Whole blood

Animal Models for Typhoid Fever or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Typhoid Fever:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053979.6SLC11A1, IL12B, LTB, HIST1H1D, RHD, G6PD

Publications for Typhoid Fever

About this section
Sources:
50PubMed
See all sources

Articles related to Typhoid Fever:

(show top 50)    (show all 607)
idTitleAuthorsYear
1
Near-fatal myocarditis complicating typhoid fever in a traveler returning from Nepal. (23992577)
2013
2
An unusual presentation of typhoid fever causing aseptic meningitis, acute pancreatitis, acute glomerulonephritis, acute hepatitis. (23324301)
2013
3
The application of the grey disaster model to forecast epidemic peaks of typhoid and paratyphoid fever in China. (23565260)
2013
4
Validation of a new serology-based dipstick test for rapid diagnosis of typhoid fever. (23420012)
2013
5
Comparative pharmacokinetics of levofloxacin in healthy volunteers and in patients suffering from typhoid Fever. (24250583)
2013
6
Cases of typhoid fever in Copenhagen region: a retrospective study of presentation and relapse. (23937856)
2013
7
Ileocecal ulceration and granulomatous ileitis as an unusual presentation of typhoid fever. (22872773)
2012
8
Vaccines for typhoid fever and other salmonelloses. (22825288)
2012
9
Ciprofloxacin resistant osteomyelitis following typhoid fever. (22802563)
2012
10
Risk factors associated with typhoid fever in children aged 2-16 years in Karachi, Pakistan. (21676350)
2012
11
Assessment and comparative analysis of a rapid diagnostic test (TubexAr) for the diagnosis of typhoid fever among hospitalized children in rural Tanzania. (21609455)
2011
12
Host response transcriptional profiling reveals extracellular components and ABC (ATP-binding cassette) transporters gene enrichment in typhoid fever-infected Nigerian children. (21914192)
2011
13
A comprehensive study of the contribution of Salmonella enterica serovar Typhimurium SPI2 effectors to bacterial colonization, survival, and replication in typhoid fever, macrophage, and epithelial cell infection models. (21540636)
2011
14
Genetically modified Bifidobacterium displaying Salmonella-antigen protects mice from lethal challenge of Salmonella Typhimurium in a murine typhoid fever model. (20709009)
2010
15
M-01ZH09, an oral live attenuated Salmonella enterica serovar Typhi vaccine for the prevention of typhoid fever. (19806505)
2009
16
Acute acalculous cholecystitis complicating typhoid fever in an adult patient: a case report and review of the literature. (19717100)
2009
17
Risk factors for typhoid fever in children in squatter settlements of Karachi: a nested case-control study. (20701852)
2008
18
Salmonella paratyphi A: an important cause of typhoid fever in Ludhiana. (19125543)
2008
19
A review of the disease burden, impact and prevention of typhoid fever in Nigeria. (19256314)
2008
20
Clean hands: prevention of typhoid fever in rural communities in Egypt. (19095588)
2007-2008
21
Salmonella enterica serovar Typhi Ty21a expressing human papillomavirus type 16 L1 as a potential live vaccine against cervical cancer and typhoid fever. (17687110)
2007
22
Multidrug-resistant typhoid fever outbreak in travelers returning from Bangladesh. (18258058)
2007
23
Dot enzyme immunoassay (Typhidot) in diagnosis of typhoid fever in children. (17387102)
2007
24
Use of paired serum samples for serodiagnosis of typhoid fever. (16145168)
2005
25
Enteric (typhoid) fever in travelers. (16231259)
2005
26
The need for another typhoid fever vaccine. (15995947)
2005
27
Osler on typhoid fever: differentiating typhoid from typhus and malaria. (15081508)
2004
28
Diagnostic methods for typhoid fever in Nigeria. (15651116)
2004
29
Febrile Broca's aphasia: a rare presentation of typhoid fever. (12757696)
2003
30
Isolated thrombocytopenia: the presenting finding of typhoid fever. (12542445)
2003
31
Typhoid fever. (12647736)
2003
32
Typhidot test to detect IgG & IgM antibodies in typhoid fever. (12592993)
2002
33
Detection of Salmonella typhi by polymerase chain reaction: implications in diagnosis of typhoid fever. (12797986)
2002
34
Blood culture confirmed typhoid fever in a provincial hospital in the Philippines. (11944712)
2001
35
An outbreak of typhoid fever, Xing-An County, People's Republic of China, 1999: estimation of the field effectiveness of Vi polysaccharide typhoid vaccine. (11372030)
2001
36
mig-14 is a horizontally acquired, host-induced gene required for salmonella enterica lethal infection in the murine model of typhoid fever. (11083839)
2000
37
Clinical application of a dot blot test for diagnosis of enteric fever due to Salmonella enterica serovar typhi in patients with typhoid fever from Colombia and Peru. (10702512)
2000
38
Azithromycin versus ceftriaxone for the treatment of uncomplicated typhoid fever in children. (11073741)
2000
39
Emergence of Salmonella typhi Vi antigen-negative strains in an epidemic of multidrug-resistant typhoid fever cases in Calcutta, India. (11558122)
2000
40
Typhoid fever presenting as infection-associated hemophagocytic syndrome: report of one case. (10910545)
1999
41
Typhoid fever complicated by acute renal failure and hepatitis: case reports and review. (9647038)
1998
42
Serum thrombomodulin levels in patients with typhoid fever. (9861408)
1998
43
Typhoid fever associated with adult respiratory distress syndrome. (8205894)
1994
44
Pseudotumor cerebri complicating typhoid fever. (2289513)
1990
45
Significance of Widal test in the diagnosis of typhoid and paratyphoid fever. (3136898)
1986
46
Typhoid fever complicated by intestinal perforation: a persisting fatal disease requiring surgical management. (3890097)
1985
47
Empyema due to splenic abscess in typhoid fever. (861600)
1977
48
Acute disseminated encephalomyelitis in typhoid fever. (1125589)
1975
49
Thrombocytopenic purpura complicating typhoid and paratyphoid fever. (18141777)
1949
50
Caries of Frontal Bone and Intracranial Abscess due to Bacillus typhosus Eleven Years after Attack of Typhoid Fever. (19976388)
1912

Genetic Variations for Typhoid Fever

About this section

Expression for genes affiliated with Typhoid Fever

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Typhoid Fever

Search GEO for disease gene expression data for Typhoid Fever.

Pathways for genes affiliated with Typhoid Fever

About this section
Sources:
37NCBI BioSystems Database, 52R&D Systems, 51QIAGEN
See all sources

Pathways related to Typhoid Fever according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.2IL12B, IFNGR1, TLR5
2
Hide members
10.1IL12B, LTB, TNFRSF9, TLR5

Compounds for genes affiliated with Typhoid Fever

About this section
Sources:
44Novoseek, 11DrugBank, 49PharmGKB, 28IUPHAR, 24HMDB
See all sources

Compounds related to Typhoid Fever according to GeneCards/GeneDecks:

(show all 35)
idCompoundScoreTop Affiliating Genes
1ertapenem4410.7LACTB, VDAC1
2moxalactam4410.7LACTB, VDAC1
3aztreonam4410.7VDAC1, LACTB
4cefoxitin4410.7VDAC1, LACTB
5tazobactam4410.6VDAC1, LACTB
6clindamycin44 1111.6LACTB, G6PD
7cefuroxime44 1111.6OMP, LACTB
8meropenem4410.6VDAC1, LACTB
9cephalosporin4410.6VDAC1, LACTB
10nitrofurantoin44 49 1112.6G6PD, LACTB
11imipenem4410.6LACTB, VDAC1, OMP
12cefepime44 1111.6VDAC1, LACTB
13ceftazidime44 1111.6LACTB, VDAC1, OMP
14beta-lactam4410.6LACTB, VDAC1
15nalidixic acid44 49 1112.6LACTB, G6PD
16ceftriaxone44 1111.6LACTB, VDAC1, G6PD
17ciprofloxacin44 1111.6OMP, VDAC1, LACTB
18cefazolin44 1111.6G6PD, LACTB
19aminoglycosides4410.6LACTB, VDAC1
20cefotaxime44 1111.5LACTB, VDAC1
21trimethoprim44 49 1112.5G6PD, LACTB
22peptidoglycan44 2811.5TLR5, OMP, VDAC1, IL12B
23norfloxacin44 49 1112.5LACTB, G6PD
24galactose-1-phosphate4410.5GALE, G6PD
25glyceraldehyde 3-phosphate4410.4G6PD, RHD, ANXA6, VDAC1
26ampicillin44 1111.4LACTB, VDAC1
27mefloquine44 1111.4RHD, G6PD
28iron44 2411.4IFNGR1, RHD, OMP, VDAC1, SLC11A1
29nad+4410.4G6PD, GALE, VDAC1
30polysaccharide4410.3GALE, RHD, OMP, VDAC1
31amoxicillin44 49 1112.3VDAC1, LACTB
32sulfamethoxazole44 49 1112.3LACTB, G6PD
33sodium dodecylsulfate4410.2IL12B, VDAC1, RHD
34penicillin4410.2VDAC1, LACTB
35dids44 2811.0VDAC1, RHD

GO Terms for genes affiliated with Typhoid Fever

About this section
Sources:
16Gene Ontology
See all sources

Biological processes related to Typhoid Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1defense response to Gram-negative bacteriumGO:05082910.3SLC11A1, IL12B
2positive regulation of T-helper 1 type immune responseGO:00282710.2SLC11A1, IL12B
3defense response to protozoanGO:04283210.0SLC11A1, IL12B

Molecular functions related to Typhoid Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine bindingGO:01995510.3TNFRSF9, IFNGR1

Products for genes affiliated with Typhoid Fever

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Typhoid Fever

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet