MCID: ULC005
MIFTS: 20

Ulcer of Lower Limbs malady

Categories: Skin diseases

Aliases & Classifications for Ulcer of Lower Limbs

Aliases & Descriptions for Ulcer of Lower Limbs:

Name: Ulcer of Lower Limbs 38 12 14
Ulcer of Heel and Midfoot 12
Ulcer of Ankle 12
Ulcer of Thigh 12
Ulcer of Calf 12

Classifications:



External Ids:

Disease Ontology 12 DOID:8529
ICD10 33 L97

Summaries for Ulcer of Lower Limbs

Disease Ontology : 12 Ulcer of lower limbs is a chronic ulcer of skin where the ulcer is not a decubitus ulcer.

MalaCards based summary : Ulcer of Lower Limbs, is also known as ulcer of heel and midfoot. An important gene associated with Ulcer of Lower Limbs is CCL5 (C-C Motif Chemokine Ligand 5). The drugs Amoxicillin and Aztreonam have been mentioned in the context of this disorder. Affiliated tissues include skin and t cells.

Related Diseases for Ulcer of Lower Limbs

Symptoms & Phenotypes for Ulcer of Lower Limbs

Drugs & Therapeutics for Ulcer of Lower Limbs

Drugs for Ulcer of Lower Limbs (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 394)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amoxicillin Approved, Vet_approved Phase 4,Phase 3 26787-78-0 33613 2171
2
Aztreonam Approved Phase 4,Phase 2 78110-38-0 5362041 5742832
3
Clindamycin Approved, Vet_approved Phase 4,Phase 2 18323-44-9 29029
4
Levofloxacin Approved, Investigational Phase 4,Phase 3,Phase 2 100986-85-4 149096
5
Linezolid Approved, Investigational Phase 4,Phase 2 165800-03-3 441401
6
Metronidazole Approved Phase 4,Phase 2 443-48-1 4173
7
Ofloxacin Approved Phase 4,Phase 3,Phase 2 82419-36-1 4583
8
Piperacillin Approved Phase 4,Phase 3,Phase 2 66258-76-2 43672
9
Tazobactam Approved Phase 4,Phase 3,Phase 2 89786-04-9 123630
10
Ciprofloxacin Approved, Investigational Phase 4,Phase 2,Phase 1 85721-33-1 2764
11
Sulfamethoxazole Approved Phase 4,Phase 2 723-46-6 5329
12
Trimethoprim Approved, Vet_approved Phase 4,Phase 2 738-70-5 5578
13
Petrolatum Approved Phase 4 8009-03-8
14
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 9552079 2713
15
Metformin Approved Phase 4,Phase 2 657-24-9 14219 4091
16
Vildagliptin Approved, Investigational Phase 4 274901-16-5 6918537
17
Penicillin V Approved, Vet_approved Phase 4 87-08-1 6869
18
Cefepime Approved Phase 4,Phase 2 88040-23-7 5479537
19
Cefotaxime Approved Phase 4 63527-52-6 456256 5742673
20
Cefoxitin Approved Phase 4 35607-66-0 441199
21
Ceftriaxone Approved Phase 4 73384-59-5 5479530 5361919
22
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 1 564-25-0 54671203
23
Fusidic Acid Approved Phase 4 6990-06-3 3000226
24
Rifampin Approved Phase 4 13292-46-1 5458213 5381226
25
Ampicillin Approved, Vet_approved Phase 4 69-53-4 6249
26
Sulbactam Approved Phase 4 68373-14-8
27
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2 50-78-2 2244
28
Omeprazole Approved, Investigational, Vet_approved Phase 4 73590-58-6 4594
29
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
30
Vancomycin Approved Phase 4,Phase 3,Phase 2,Phase 1 1404-90-6 441141 14969
31
Zinc Approved Phase 4 7440-66-6 32051 23994
32
Coal tar Approved Phase 4 8007-45-2
33
Polidocanol Approved Phase 4 9002-92-0
34
Saxagliptin Approved Phase 4 361442-04-8 11243969
35
Dimenhydrinate Approved Phase 4 523-87-5 441281
36
Daptomycin Approved, Investigational Phase 4,Phase 3,Phase 2 103060-53-3 16129629
37
Bacitracin Approved, Vet_approved Phase 4 1405-87-4 439542 10909430
38
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 59-30-3 6037
39
leucovorin Approved, Nutraceutical Phase 4,Phase 2 58-05-9 54575, 6560146 143
40
Vitamin C Approved, Nutraceutical Phase 4,Phase 1 50-81-7 5785 54670067
41 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1
42 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Phase 1
43 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1
44 Antitubercular Agents Phase 4,Phase 3,Phase 2,Phase 1
45 Clavulanic Acid Phase 4,Phase 3
46 Clindamycin palmitate Phase 4,Phase 2
47 Clindamycin phosphate Phase 4,Phase 2
48 Gentamicins Phase 4,Phase 3,Phase 2,Phase 1
49 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Phase 1
50 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 758)
id Name Status NCT ID Phase
1 A Study Of Pain And Quality Of Life Outcomes In Subjects With a Single Painful Venous Leg Ulcer Treated With Apligraf® Unknown status NCT02011724 Phase 4
2 Outcomes of Non-infected Diabetic Foot Ulcers With/Without Antibiotics Unknown status NCT01418456 Phase 4
3 Efficacy and Safety of Garamycin® Sponge (Gentamicin-Collagen Sponge) in Diabetic Patients With a Moderate or Severe Foot Ulcer Infection Unknown status NCT01951768 Phase 4
4 Clinical Evaluation of the SNaP Wound Care System Unknown status NCT01113658 Phase 4
5 Biatain Ag vs Biatain in the Treament of Leg Ulcers Completed NCT00807664 Phase 4
6 Physiotulle vs Urgotul in the Treatment of Leg Ulcer Completed NCT01238419 Phase 4
7 Evaluation of Pain Associated With the Removal of Wound Dressing During Care of Venous Leg Ulcer. Comparison of the Efficacy and Safety of Two Dressings Urgotul and TulleGras Completed NCT02104180 Phase 4
8 A Study to Evaluate the Clinical Effectiveness of a Collagen-ORC Antimicrobial Matrix in Venous Leg Ulcers Completed NCT00235209 Phase 4
9 AQUACEL® Ag Dressing and Urgotul® Silver Dressing on Healing of Chronic Venous Leg Ulcers Completed NCT01084577 Phase 4
10 Evaluating the Efficacy of an Absorbent Foam Dressing Containing Silver (Mepilex Ag) Versus the Same Dressing Without Silver Used on Subjects With Venous Leg Ulcers or Mixed Ulcers Completed NCT01036438 Phase 4
11 A Pilot Trial of the Use of ReCell® Autologous Cell Harvesting Device for Venous Leg Ulcers Completed NCT01743053 Phase 4
12 Trial on the Efficacy of Prontosan Wound Irrigation Solution and Prontosan Wound Gel Completed NCT01153633 Phase 4
13 A Post Marketing Study of Apligraf in Non-healing Wounds of Subjects With Venous Leg Ulcers Completed NCT01327937 Phase 4
14 Clinical Trial to Evaluate the Efficacy, Tolerance and Acceptability of URGO Dressing vs a Hydrofibre in the Local Management of Venous or Predominantly Venous Mixed Leg Ulcers. Completed NCT01449422 Phase 4
15 Study Comparing VERSAJET With Conventional Surgical Procedures in the Removal of Unhealthy Tissue From Lower Limb Ulcers Completed NCT00521027 Phase 4
16 Hyperbaric Oxygen Therapy (HBOT) for Chronic Diabetic Lower Limb Ulcers Completed NCT00621608 Phase 4
17 DermACELL in Subjects With Chronic Wounds of the Lower Extremities Completed NCT01970163 Phase 4
18 Skin Ulcers Treatment With an Handicraft Topical Device Completed NCT02512159 Phase 4
19 Phase IV Study to Evaluate the Efficacy of AMNIOEXCEL in Diabetic Foot Ulcers Completed NCT02209051 Phase 4
20 Polydeoxyribonucleotide -Placentex Mastelli(Pdrn) for the Treatment of Diabetic Ulcers Completed NCT00638872 Phase 4
21 Hyperbaric Oxygen Therapy as Adjunctive Treatment of Chronic Diabetic Foot Ulcers Completed NCT00953186 Phase 4
22 Wound Fluid Protease Levels During Use of Novel Wound Dressing Completed NCT01567150 Phase 4
23 Neuromuscular Electrical Therapy in Venous Ulcers Completed NCT01372020 Phase 4
24 Diabetic Foot Ulcer Study on Topical Interventions Completed NCT02577900 Phase 4
25 LeucoPatch™ Study A Multicenter Study on the Effect of LeucoPatch™ in Diabetic Foot Ulcers Completed NCT01454401 Phase 4
26 Randomized, Controlled Multicenter Trial of Vacuum Assisted Closure Therapy™ in Diabetic Foot Ulcers Completed NCT00432965 Phase 4
27 Use of Santyl in Diabetic Foot Ulcers Completed NCT02581488 Phase 4
28 Evaluation of the Effect of Vivostat Platelet Rich Fibrin(PRF) in the Treatment of Diabetic Foot Ulcers Completed NCT00770939 Phase 4
29 Santyl Applications to Diabetic Foot Ulcers Completed NCT02111291 Phase 4
30 Diabetic Foot Ulcer. Effectiveness of Chlorhexidine Gluconate 0.125 % Compared With Sterile Deionized Water Completed NCT02097615 Phase 4
31 Grafix® DFU: Open-Label Extension Option to Evaluate Safety & Efficacy of Grafix® for Chronic Diabetic Foot Ulcers Completed NCT01596920 Phase 4
32 Study of Oasis Ultra in Diabetic Foot Ulcers Completed NCT01835379 Phase 4
33 Evaluation of the Clinical Effectiveness of a Collagen-ORC Antimicrobial Matrix in Full-Thickness, Neuropathic Diabetic Foot Ulcers Completed NCT00235196 Phase 4
34 A Study to Look at the Effects of Four Weeks of Treatment on the Healing of Diabetic Foot Ulcers Completed NCT01143714 Phase 4
35 DPP IV Inhibition Facilitates Healing of Chronic Foot Ulcers in Type 2 Diabetes Completed NCT01472432 Phase 4
36 TITLE: An Open, Non-comparative, Multi-centre Post Marketing Clinical Follow-up (PMCF) Investigation to Evaluate Performance and Safety on Diabetic Foot Ulcer, DFU, When Using Mepilex Transfer Ag as Intended Completed NCT01964521 Phase 4
37 Enzymatic Versus (vs) Autolytic Debridement of Diabetic Foot Ulcers Completed NCT01143727 Phase 4
38 Using Santyl on Diabetic Foot Ulcers Completed NCT01408277 Phase 4
39 Wound Edge Changes Following Treatment With Santyl Completed NCT01197898 Phase 4
40 OASIS Wound Matrix (Oasis) Mechanism of Action Completed NCT00570141 Phase 4
41 Santyl vs. Sharp Debridement of Diabetic Foot Wounds Completed NCT01056198 Phase 4
42 RCT to Investigate if Prophylactic Antibiotics Prevent Further Episodes of Cellulitis (Erysipelas) of the Leg Completed NCT00552799 Phase 4
43 GrafixCORE®: Open-Label Study to Evaluate the Safety and Efficacy of GrafixCORE® for Complex Diabetic Foot Wounds Completed NCT02260609 Phase 4
44 A Complicated Skin and Soft-tissue Infection Patient Registry Completed NCT00737269 Phase 4
45 Trial of Vacuum Assisted Closure® Therapy in Amputation Wounds of the Diabetic Foot Completed NCT00224796 Phase 4
46 Antibiotic Treatment Duration for Non-Surgically-Treated Diabetic Foot Osteomyelitis Completed NCT02123628 Phase 4
47 Study Evaluating the Safety and Efficacy of Piperacillin/Tazobactam and Ampicillin/Sulbactam in Patients With Diabetic Foot Infections Completed NCT00044746 Phase 4
48 Peripheral Vascular Disease and Nerve Stimulation Completed NCT01942941 Phase 4
49 Iliac Vein Stenting in Advanced Chronic Venous Insufficiency Completed NCT02149212 Phase 4
50 Aspirin Withdrawal in Non-ischaemic Cardiomyopathy Study Completed NCT01534026 Phase 4

Search NIH Clinical Center for Ulcer of Lower Limbs

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Ulcer of Lower Limbs cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Ulcer of Lower Limbs:
Peripheral blood-derived hematopoietic stem cells for leg gangrene
Embryonic/Adult Cultured Cells Related to Ulcer of Lower Limbs:
Peripheral blood-derived hematopoietic stem cells

Genetic Tests for Ulcer of Lower Limbs

Anatomical Context for Ulcer of Lower Limbs

MalaCards organs/tissues related to Ulcer of Lower Limbs:

39
Skin, T Cells

Publications for Ulcer of Lower Limbs

Articles related to Ulcer of Lower Limbs:

id Title Authors Year
1
[The value of regulated upon activation normal T cell expressed and secreted in the pathogenesis of varicose ulcer of lower limbs]. ( 19953896 )
2009

Variations for Ulcer of Lower Limbs

Expression for Ulcer of Lower Limbs

Search GEO for disease gene expression data for Ulcer of Lower Limbs.

Pathways for Ulcer of Lower Limbs

GO Terms for Ulcer of Lower Limbs

Sources for Ulcer of Lower Limbs

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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