MCID: ULC005
MIFTS: 23

Ulcer of Lower Limbs

Categories: Skin diseases

Aliases & Classifications for Ulcer of Lower Limbs

MalaCards integrated aliases for Ulcer of Lower Limbs:

Name: Ulcer of Lower Limbs 37 12 14
Ulcer of Heel and Midfoot 12
Ulcer of Ankle 12
Ulcer of Thigh 12
Ulcer of Calf 12

Classifications:



External Ids:

Disease Ontology 12 DOID:8529
ICD10 32 L97

Summaries for Ulcer of Lower Limbs

Disease Ontology : 12 Ulcer of lower limbs is a chronic ulcer of skin where the ulcer is not a decubitus ulcer.

MalaCards based summary : Ulcer of Lower Limbs, is also known as ulcer of heel and midfoot. An important gene associated with Ulcer of Lower Limbs is CCL5 (C-C Motif Chemokine Ligand 5). The drugs Amoxicillin and Aztreonam have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and bone marrow.

Related Diseases for Ulcer of Lower Limbs

Symptoms & Phenotypes for Ulcer of Lower Limbs

Drugs & Therapeutics for Ulcer of Lower Limbs

Drugs for Ulcer of Lower Limbs (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 331)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amoxicillin Approved, Vet_approved Phase 4,Phase 3 26787-78-0 33613 2171
2
Aztreonam Approved Phase 4,Phase 2 78110-38-0 5742832 5362041
3
Clindamycin Approved, Vet_approved Phase 4,Phase 2 18323-44-9 29029
4
Levofloxacin Approved, Investigational Phase 4,Phase 3,Phase 2 100986-85-4 149096
5
Linezolid Approved, Investigational Phase 4,Phase 2 165800-03-3 441401
6
Metronidazole Approved Phase 4,Phase 2 443-48-1 4173
7
Ofloxacin Approved Phase 4,Phase 3,Phase 2 82419-36-1 4583
8
Piperacillin Approved Phase 4,Phase 3,Phase 2 66258-76-2 43672
9
Tazobactam Approved Phase 4,Phase 3,Phase 2 89786-04-9 123630
10
Alginic acid Approved, Experimental, Investigational Phase 4,Phase 1,Phase 2 9005-32-7
11
Ciprofloxacin Approved, Investigational Phase 4,Phase 2,Phase 1 85721-33-1 2764
12
Sulfamethoxazole Approved Phase 4,Phase 2 723-46-6 5329
13
Trimethoprim Approved, Vet_approved Phase 4,Phase 2 738-70-5 5578
14
Petrolatum Approved, Investigational Phase 4 8009-03-8
15
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 2713 9552079
16
Cefepime Approved, Investigational Phase 4,Phase 2 88040-23-7 5479537
17
Cefotaxime Approved Phase 4 63527-52-6 5742673 456256
18
Cefoxitin Approved Phase 4 35607-66-0 441199
19
Ceftriaxone Approved Phase 4 73384-59-5 5479530 5361919
20
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 1 564-25-0 54671203
21
Fusidic Acid Approved, Investigational Phase 4 6990-06-3 3000226
22
Rifampin Approved Phase 4 13292-46-1 5381226 5458213
23
Metformin Approved Phase 4,Phase 2 657-24-9 4091 14219
24
Vildagliptin Approved, Investigational Phase 4 274901-16-5 6918537
25
Ampicillin Approved, Vet_approved Phase 4 69-53-4 6249
26
Sulbactam Approved Phase 4 68373-14-8
27 Sultamicillin Approved, Investigational Phase 4 76497-13-7
28
Ropivacaine Approved Phase 4 84057-95-4 175805 71273
29
Vancomycin Approved Phase 4,Phase 3,Phase 2 1404-90-6 14969 441141
30
Thrombin Approved, Investigational Phase 4,Phase 3,Phase 2
31
Zinc Approved, Investigational Phase 4 7440-66-6 32051 23994
32
Saxagliptin Approved Phase 4 361442-04-8 11243969
33
Daptomycin Approved, Investigational Phase 4,Phase 3,Phase 2 103060-53-3 16129629
34
Coal tar Approved Phase 4 8007-45-2
35
Dimenhydrinate Approved Phase 4 523-87-5 441281
36
Polidocanol Approved Phase 4 9002-92-0
37
Bacitracin Approved, Vet_approved Phase 4 1405-87-4 10909430 439542
38
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2 59-30-3 6037
39
leucovorin Approved, Nutraceutical Phase 4,Phase 2 58-05-9 143 6006
40
Vitamin C Approved, Nutraceutical Phase 4 50-81-7 54670067 5785
41 Octenidine Investigational Phase 4 71251-02-0
42 Anti-Bacterial Agents Phase 4,Phase 3,Phase 1,Phase 2
43 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 1,Phase 2
44 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1
45 Antitubercular Agents Phase 4,Phase 3,Phase 2
46 Clavulanic Acid Phase 4,Phase 3
47 Clindamycin palmitate Phase 4,Phase 2
48 Clindamycin phosphate Phase 4,Phase 2
49 Gentamicins Phase 4,Phase 3,Phase 2,Phase 1
50 Carboxymethylcellulose Sodium Phase 4,Phase 3,Phase 1,Phase 2

Interventional clinical trials:

(show top 50) (show all 712)

# Name Status NCT ID Phase Drugs
1 A Study Of Pain And Quality Of Life Outcomes In Subjects With a Single Painful Venous Leg Ulcer Treated With Apligraf® Unknown status NCT02011724 Phase 4
2 Outcomes of Non-infected Diabetic Foot Ulcers With/Without Antibiotics Unknown status NCT01418456 Phase 4 antibiotics
3 A Comparative Efficacy Study of DermaPure™ to Treat Diabetic Foot Ulcers Unknown status NCT02081352 Phase 4
4 Efficacy and Safety of Garamycin® Sponge (Gentamicin-Collagen Sponge) in Diabetic Patients With a Moderate or Severe Foot Ulcer Infection Unknown status NCT01951768 Phase 4 Garamycin Sponge (Gentamicin-Collagen sponge);Systemic Antibiotic
5 Clinical Evaluation of the SNaP Wound Care System Unknown status NCT01113658 Phase 4
6 Physiotulle vs Urgotul in the Treatment of Leg Ulcer Completed NCT01238419 Phase 4
7 Evaluation of Pain Associated With the Removal of Wound Dressing During Care of Venous Leg Ulcer. Comparison of the Efficacy and Safety of Two Dressings Urgotul and TulleGras Completed NCT02104180 Phase 4
8 AQUACEL® Ag Dressing and Urgotul® Silver Dressing on Healing of Chronic Venous Leg Ulcers Completed NCT01084577 Phase 4
9 A Study to Evaluate the Clinical Effectiveness of a Collagen-ORC Antimicrobial Matrix in Venous Leg Ulcers Completed NCT00235209 Phase 4
10 Evaluating the Efficacy of an Absorbent Foam Dressing Containing Silver (Mepilex Ag) Versus the Same Dressing Without Silver Used on Subjects With Venous Leg Ulcers or Mixed Ulcers Completed NCT01036438 Phase 4
11 A Pilot Trial of the Use of ReCell® Autologous Cell Harvesting Device for Venous Leg Ulcers Completed NCT01743053 Phase 4
12 Trial on the Efficacy of Prontosan Wound Irrigation Solution and Prontosan Wound Gel Completed NCT01153633 Phase 4
13 A Post Marketing Study of Apligraf in Non-healing Wounds of Subjects With Venous Leg Ulcers Completed NCT01327937 Phase 4
14 Clinical Trial to Evaluate the Efficacy, Tolerance and Acceptability of URGO Dressing vs a Hydrofibre in the Local Management of Venous or Predominantly Venous Mixed Leg Ulcers. Completed NCT01449422 Phase 4
15 Study Comparing VERSAJET With Conventional Surgical Procedures in the Removal of Unhealthy Tissue From Lower Limb Ulcers Completed NCT00521027 Phase 4
16 Hyperbaric Oxygen Therapy as Adjunctive Treatment of Chronic Diabetic Foot Ulcers Completed NCT00953186 Phase 4
17 Polydeoxyribonucleotide -Placentex Mastelli(Pdrn) for the Treatment of Diabetic Ulcers Completed NCT00638872 Phase 4 Polydeoxyribonucleotide
18 Neuromuscular Electrical Therapy in Venous Ulcers Completed NCT01372020 Phase 4
19 Diabetic Foot Ulcer Study on Topical Interventions Completed NCT02577900 Phase 4
20 Skin Ulcers Treatment With an Handicraft Topical Device Completed NCT02512159 Phase 4
21 Diabetic Foot Ulcer. Effectiveness of Chlorhexidine Gluconate 0.125 % Compared With Sterile Deionized Water Completed NCT02097615 Phase 4
22 DermACELL in Subjects With Chronic Wounds of the Lower Extremities Completed NCT01970163 Phase 4
23 GrafixPRIME® for the Treatment of Chronic Diabetic Foot Ulcers Completed NCT02675855 Phase 4
24 Use of Santyl in Diabetic Foot Ulcers Completed NCT02581488 Phase 4
25 GrafixCORE®: Open-Label Study to Evaluate the Safety and Efficacy of GrafixCORE® for Complex Diabetic Foot Wounds Completed NCT02260609 Phase 4
26 Santyl Applications to Diabetic Foot Ulcers Completed NCT02111291 Phase 4
27 TITLE: An Open, Non-comparative, Multi-centre Post Marketing Clinical Follow-up (PMCF) Investigation to Evaluate Performance and Safety on Diabetic Foot Ulcer, DFU, When Using Mepilex Transfer Ag as Intended Completed NCT01964521 Phase 4
28 Study of Oasis Ultra in Diabetic Foot Ulcers Completed NCT01835379 Phase 4
29 Santyl vs. Sharp Debridement of Diabetic Foot Wounds Completed NCT01056198 Phase 4 Santyl
30 Grafix® DFU: Open-Label Extension Option to Evaluate Safety & Efficacy of Grafix® for Chronic Diabetic Foot Ulcers Completed NCT01596920 Phase 4
31 LeucoPatch™ Study A Multicenter Study on the Effect of LeucoPatch™ in Diabetic Foot Ulcers Completed NCT01454401 Phase 4
32 Antibiotic Treatment Duration for Non-Surgically-Treated Diabetic Foot Osteomyelitis Completed NCT02123628 Phase 4 duration of the antibiotic therapy
33 Using Santyl on Diabetic Foot Ulcers Completed NCT01408277 Phase 4
34 Wound Edge Changes Following Treatment With Santyl Completed NCT01197898 Phase 4
35 Enzymatic Versus (vs) Autolytic Debridement of Diabetic Foot Ulcers Completed NCT01143727 Phase 4 Santyl;Tegaderm Hydrogel
36 A Study to Look at the Effects of Four Weeks of Treatment on the Healing of Diabetic Foot Ulcers Completed NCT01143714 Phase 4 Santyl
37 Wound Fluid Protease Levels During Use of Novel Wound Dressing Completed NCT01567150 Phase 4
38 DPP IV Inhibition Facilitates Healing of Chronic Foot Ulcers in Type 2 Diabetes Completed NCT01472432 Phase 4 Placebo;vildagliptin
39 Evaluation of the Effect of Vivostat Platelet Rich Fibrin(PRF) in the Treatment of Diabetic Foot Ulcers Completed NCT00770939 Phase 4
40 A Complicated Skin and Soft-tissue Infection Patient Registry Completed NCT00737269 Phase 4
41 OASIS Wound Matrix (Oasis) Mechanism of Action Completed NCT00570141 Phase 4
42 Evaluation of the Clinical Effectiveness of a Collagen-ORC Antimicrobial Matrix in Full-Thickness, Neuropathic Diabetic Foot Ulcers Completed NCT00235196 Phase 4
43 Trial of Vacuum Assisted Closure® Therapy in Amputation Wounds of the Diabetic Foot Completed NCT00224796 Phase 4
44 Study Evaluating the Safety and Efficacy of Piperacillin/Tazobactam and Ampicillin/Sulbactam in Patients With Diabetic Foot Infections Completed NCT00044746 Phase 4 Piperacillin/Tazobactam
45 To Assess Analgesia Provided by Continuous Sciatic Nerve Block in Patients With Hypertensive Leg Ulcer Recruiting NCT01964911 Phase 4 Ropivacaïne
46 Juxta-CuresTM Versus Bandaging for Venous Ulcers Recruiting NCT02790593 Phase 4
47 Chlorhexidine Gluconate Solution at 0.125% vs Placebo for the Healing of Grade IIB Ulcers of Diabetic Foot Recruiting NCT03209466 Phase 4 Chlorhexidine gluconate at 0.125%;Placebo Comparator with physiological saline sterile solution
48 Maggot Debridement Therapy Versus Conventional Dressing Therapy to Treat Diabetic Foot Ulcers Recruiting NCT02816749 Phase 4
49 A Feasibility Study of the ReGenerCell™ Autologous Cell Harvesting Device for Diabetic Foot Ulcers Recruiting NCT02799121 Phase 4
50 Dipeptidyl Peptidase 4 Inhibition Facilitate Healing of Diabetic Ulcers Recruiting NCT02742233 Phase 4 saxagliptin;placebo

Search NIH Clinical Center for Ulcer of Lower Limbs

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Ulcer of Lower Limbs cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Ulcer of Lower Limbs:
Peripheral blood-derived hematopoietic stem cells for leg gangrene
Embryonic/Adult Cultured Cells Related to Ulcer of Lower Limbs:
Peripheral blood-derived hematopoietic stem cells

Genetic Tests for Ulcer of Lower Limbs

Anatomical Context for Ulcer of Lower Limbs

MalaCards organs/tissues related to Ulcer of Lower Limbs:

38
Skin, Bone, Bone Marrow, Testes, Endothelial, Colon, Heart

Publications for Ulcer of Lower Limbs

Articles related to Ulcer of Lower Limbs:

# Title Authors Year
1
[The value of regulated upon activation normal T cell expressed and secreted in the pathogenesis of varicose ulcer of lower limbs]. ( 19953896 )
2009

Variations for Ulcer of Lower Limbs

Expression for Ulcer of Lower Limbs

Search GEO for disease gene expression data for Ulcer of Lower Limbs.

Pathways for Ulcer of Lower Limbs

GO Terms for Ulcer of Lower Limbs

Sources for Ulcer of Lower Limbs

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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