UC
MCID: ULC004
MIFTS: 72

Ulcerative Colitis (UC) malady

Gastrointestinal diseases category

Summaries for Ulcerative Colitis

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21Genetics Home Reference, 33MedlinePlus, 3CDC, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 Ulcerative colitis (uc) is a disease that causes inflammation and sores, called ulcers, in the lining of the rectum and colon. it is one of a group of diseases called inflammatory bowel disease. uc can happen at any age, but it usually starts between the ages of 15 and 30. it tends to run in families. the most common symptoms are pain in the abdomen and blood or pus in diarrhea. other symptoms may include anemia severe tiredness weight loss loss of appetite bleeding from the rectum sores on the skin joint pain growth failure in children about half of people with uc have mild symptoms. doctors use blood tests, stool tests, colonoscopy or sigmoidoscopy, and imaging tests to diagnose uc. several types of drugs can help control it. some people have long periods of remission, when they are free of symptoms. in severe cases, doctors must remove the colon. nih: national institute of diabetes and digestive and kidney diseases

MalaCards: Ulcerative Colitis, also known as idiopathic proctocolitis, is related to crohn's disease and inflammatory bowel disease. An important gene associated with Ulcerative Colitis is IL2 (interleukin 2), and among its related pathways are PAK Pathway and Immune response Fc epsilon RI pathway. The drugs azathioprine and hydrocortisone and the compounds peptidoglycan and prednisolone have been mentioned in the context of this disorder. Affiliated tissues include colon, testes and skin, and related mouse phenotypes are immune system and hematopoietic system.

Genetics Home Reference:21 Ulcerative colitis is a chronic disorder that affects the digestive system. This condition is characterized by abnormal inflammation of the inner surface of the rectum and colon, which make up most of the length of the large intestine. The inflammation usually causes open sores (ulcers) to develop in the large intestine. Ulcerative colitis usually appears between ages 15 and 30, although it can develop at any age. The inflammation tends to flare up multiple times throughout life, which causes recurring signs and symptoms.

CDC:3 Inflammatory Bowel Diseases (IBD) is a broad term that describes conditions with chronic or recurring immune response and inflammation of the gastrointestinal tract. The two most common inflammatory bowel diseases are ulcerative colitis and Crohn’s disease.

Wikipedia:63 Ulcerative colitis (Colitis ulcerosa, UC) is a form of inflammatory bowel disease (IBD). Ulcerative... more...

Description from OMIM:46 266600

Aliases & Classifications for Ulcerative Colitis

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Sources:
8Disease Ontology, 21Genetics Home Reference, 10DISEASES, 44Novoseek, 33MedlinePlus, 30LifeMap Discovery™, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH, 27ICD9CM, 46OMIM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

ulcerative colitis 8 21 10 33 30 60
idiopathic proctocolitis 21 60
inflammatory bowel disease, ulcerative colitis type 21
chronic left-sided ulcerative colitis 60
left-sided ulcerative colitis 8
colitis ulcerative 44
colitis gravis 21
uc 21


External Ids:

Disease Ontology8 DOID:8577
NCIt39 C2952
MeSH34 D003093
ICD9CM27 556, 556.9
OMIM46 266600
ICD1025 K51

Related Diseases for Ulcerative Colitis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Ulcerative Colitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 323)
idRelated DiseaseScoreTop Affiliating Genes
1crohn's disease31.6TNFSF15, TNF, NKX2-3, NOD2
2inflammatory bowel disease31.1CCL11, TNFSF15, TNF, CTSG, MYO9B, MUC2
3colorectal cancer31.1NOD2, IL2, MUC2
4arthritis30.7TNF, CTSG, NOD2
5dermatitis30.7NOD2, CCL11
6rheumatoid arthritis30.6CCL11, TNF, CTSG, IL2, NOD2
7celiac disease30.5MYO9B
8bronchiolitis30.5CCL11
9dermatitis herpetiformis30.5CCL11
10sarcoidosis30.3NOD2, IL2, BTNL2, TNF, CCL11
11uveitis30.3NOD2, TNF, CCL11
12ankylosing spondylitis30.3TNF
13spondylitis30.3NOD2
14wegener's granulomatosis30.3CTSG
15tuberculosis30.3TNF, CTSG, IL2, NOD2
16glomerulonephritis30.2CTSG
17systemic lupus erythematosus30.0NOD2, IL2, CTSG, TNF
18cholera29.9CCL11, MUC2
19peritonitis29.9CTSG, TNF
20sclerosing cholangitis10.9
21cholangitis10.9
22megacolon10.8
23toxic megacolon10.8
24proctitis10.8
25pyoderma10.7
26pyoderma gangrenosum10.7
27colonic disease10.6
28familial adenomatous polyposis10.6
29hepatitis10.6
30cerebritis10.6
31intestinal disease10.6
32pericholangitis10.6
33adenocarcinoma10.6
34colon cancer10.5
35duodenal ulcer10.5
36duodenitis10.5
37hepatitis a10.5
38irritable bowel syndrome10.4
39adenoma10.4
40bile duct carcinoma10.4
41pancreatitis10.4
42pneumonia10.4
43vasculitis10.4
44takayasu's arteritis10.4
45portal vein thrombosis10.4
46autoimmune hemolytic anemia10.4
47autoimmune hepatitis10.4
48gastroduodenitis10.4
49diarrhea10.4
50hemolytic anemia10.4

Graphical network of the top 20 diseases related to Ulcerative Colitis:



Diseases related to ulcerative colitis

Clinical Features for Ulcerative Colitis

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Sources:
46OMIM
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Clinical features from OMIM:

266600

Drugs & Therapeutics for Ulcerative Colitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Ulcerative Colitis

Drug clinical trials:

Search ClinicalTrials for Ulcerative Colitis

Search NIH Clinical Center for Ulcerative Colitis

Search CenterWatch for Ulcerative Colitis

Inferred drug relations via UMLS60/NDF-RT40:

Show with subtypes

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Ulcerative Colitis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Ulcerative Colitis:
MultiStem
Embryonic/Adult Cultured Cells Related to Ulcerative Colitis:
Bone marrow-derived adherent progenitor cells (MultiStem)

Genetic Tests for Ulcerative Colitis

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Anatomical Context for Ulcerative Colitis

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30LifeMap Discovery™, 32MalaCards
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MalaCards organs/tissues related to Ulcerative Colitis:

32
Colon, Testes, Skin, T cells, Kidney, Bone, Liver, Monocytes, Bone marrow, Endothelial, Thyroid, Appendix, B cells, Myeloid, Whole blood, Smooth muscle, Prostate, Pancreas, Spinal cord, Breast, Lymph node, Eye, Lung, Thymus

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Ulcerative Colitis:
id TissueAnatomical CompartmentCell Relevance
1 BoneBone MarrowBone Marrow Stromal Cells Potential therapeutic candidate

Animal Models for Ulcerative Colitis or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Ulcerative Colitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538712.1NOD2, CCL11, CARD9, TNFSF15, TNF, CTSG
2MP:000539711.7CTSG, TNF, TNFSF15, CCL11, NKX2-3, MYO9B
3MP:000538111.4NKX2-3, MUC2, CLDN18, IL2, NOD2, TNF

Publications for Ulcerative Colitis

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Sources:
50PubMed
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Articles related to Ulcerative Colitis:

(show top 50)    (show all 2034)
idTitleAuthorsYear
1
Effect of Probiotics on Inducing Remission and Maintaining Therapy in Ulcerative Colitis, Crohn's Disease, and Pouchitis: Meta-analysis of Randomized Controlled Trials. (24280877)
2014
2
Ulcerative colitis: prevention of relapse. (23639092)
2013
3
Association of linear IgA bullous disease with ulcerative colitis: a case of successful treatment with infliximab. (24281360)
2013
4
Fecal calprotectin and clinical disease activity in pediatric ulcerative colitis. (23533791)
2013
5
Lactobacillus bacteremia associated with probiotic use in a pediatric patient with ulcerative colitis. (23426446)
2013
6
Interleukin-17 serum levels and TLR4 polymorphisms in ulcerative colitis. (23811547)
2013
7
Infliximab administration prior to surgery does not increase surgical site infections in patients with ulcerative colitis. (23604447)
2013
8
State-of-the-art surgical approaches to the treatment of medically refractory ulcerative colitis. (24002758)
2013
9
Budesonide (Uceris) for ulcerative colitis. (23507873)
2013
10
Effect of steroid sparing agents on the clinical course of ulcerative colitis. (23809429)
2013
11
Gene expression of solute carrier family 9 (sodium/hydrogen exchanger) 3, (SLC9A3) is downregulated in patients with ulcerative colitis. (22447429)
2012
12
Psoriatic colitis mimicking ulcerative proctitis in an elderly patient. (22884084)
2012
13
Matrix metalloproteinases in the restorative proctocolectomy pouch of pediatric ulcerative colitis. (22912554)
2012
14
C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) or both? A systematic evaluation in pediatric ulcerative colitis. (21939916)
2011
15
Treatment and prevention of pouchitis after ileal pouch-anal anastomosis for chronic ulcerative colitis. (20556748)
2010
16
Detection of epithelial apoptosis in pelvic ileal pouches for ulcerative colitis and familial adenomatous polyposis. (20113505)
2010
17
Solitary rectal ulcer syndrome in association with ulcerative colitis: a case report. (19418566)
2010
18
Genetics of ulcerative colitis: the come-back of interleukin 10. (19671546)
2009
19
Different regulation of eosinophil activity in Crohn's disease compared with ulcerative colitis. (18801925)
2008
20
Increased intestinal expression of heme oxygenase-1 and its localization in patients with ulcerative colitis. (19120903)
2008
21
A case study: interferon-beta-induced remission of ulcerative colitis in a patient with type C chronic hepatitis]. (18772577)
2008
22
Pyoderma gangrenosum and ulcerative colitis in the tropics. (19142449)
2008
23
Genetic analysis of innate immunity in Crohn's disease and ulcerative colitis identifies two susceptibility loci harboring CARD9 and IL18RAP. (18439550)
2008
24
Evaluation of the MLH1 I219V alteration in DNA mismatch repair activity and ulcerative colitis. (18200512)
2008
25
Pouchitis and pre-pouch ileitis developed after restorative proctocolectomy for ulcerative colitis: a case report. (17278237)
2007
26
Expression of interleukin-12-related cytokine transcripts in inflammatory bowel disease: elevated interleukin-23p19 and interleukin-27p28 in Crohn's disease but not in ulcerative colitis. (15674109)
2005
27
Leptin levels in the acute stage of ulcerative colitis. (15012781)
2004
28
MDR1 mRNA expressions in peripheral blood mononuclear cells of patients with ulcerative colitis in relation to glucocorticoid administration. (15102868)
2004
29
Glucocorticoid receptor expression in inflammatory bowel disease: evidence for a mucosal down-regulation in steroid-unresponsive ulcerative colitis. (14687166)
2004
30
The effects of anti-inflammatory on activation of nuclear factor-kappaB and expression of cell adhesion molecules in patients with ulcerative colitis]. (15553846)
2004
31
Association between the interleukin-1 receptor antagonist polymorphism and ulcerative colitis with younger age at diagnosis. (14611908)
2003
32
Oxazolone colitis, a Th2 colitis model resembling ulcerative colitis, is mediated by IL-13-producing NK-T cells. (12433369)
2002
33
Ulcerative duodenitis accompanying ulcerative colitis. (11205658)
2001
34
Association of susceptibility locus for inflammatory bowel disease on chromosome 16 with both ulcerative colitis and Crohn's disease. (11318544)
2001
35
Mannan-binding lectin (MBL) gene polymorphisms in ulcerative colitis and Crohn's disease. (11607788)
2001
36
Clinical, biological, and histologic parameters as predictors of relapse in ulcerative colitis. (11208709)
2001
37
Spontaneous chronic colitis in TCR alpha-mutant mice; an experimental model of human ulcerative colitis. (10723681)
2000
38
A case of "cap polyposis"-like lesion associated with ulcerative colitis: is this a case of cap polyposis? (11095366)
2000
39
The serum factor from patients with ulcerative colitis that induces T cell proliferation in the mouse thymus is interleukin-7. (9258767)
1997
40
No involvement of APC gene mutations in ulcerative colitis-associated rat colon carcinogenesis induced by 1-hydroxyanthraquinone and methylazoxymethanol acetate. (9433483)
1997
41
Serum aminoterminal propeptide of type III procollagen (S-PIIINP) and hepatobiliary dysfunction in patients with ulcerative colitis. (9249877)
1997
42
Inflammatory mediators and acute phase proteins in patients with Crohn's disease and ulcerative colitis. (9058126)
1997
43
Differences in immunophenotyping of mucosal lymphocytes between ulcerative colitis and Crohn's disease. (9159031)
1997
44
The myeloic related protein MRP8/14 (27E10 antigen)--usefulness as a potential marker for disease activity in ulcerative colitis and putative biological function. (7498239)
1995
45
K-ras mutations and p53 alterations in neoplastic and nonneoplastic lesions associated with longstanding ulcerative colitis. (8160776)
1994
46
Cyclosporin A retention enemas in refractory distal ulcerative colitis and 'pouchitis'. (8210986)
1993
47
p-ANCA as a diagnostic marker in ulcerative colitis. (8296670)
1993
48
Elevation of phospholipase A2 protein in sera of patients with Crohn's disease and ulcerative colitis. (8317409)
1993
49
5-Aminosalicylic acid enema in the treatment of distal ulcerative colitis, proctosigmoiditis, and proctitis. (3569765)
1987
50
Sodium cromoglycate in proctitis and ulcerative colitis. (6119135)
1982

Genetic Variations for Ulcerative Colitis

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Expression for genes affiliated with Ulcerative Colitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Ulcerative Colitis

Search GEO for disease gene expression data for Ulcerative Colitis.

Pathways for genes affiliated with Ulcerative Colitis

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Sources:
51QIAGEN, 12EMD Millipore, 29KEGG, 53Reactome, 37NCBI BioSystems Database
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Compounds for genes affiliated with Ulcerative Colitis

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 59Tocris Bioscience, 24HMDB, 49PharmGKB
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Compounds related to Ulcerative Colitis according to GeneCards/GeneDecks:

(show all 17)
idCompoundScoreTop Affiliating Genes
1peptidoglycan44 2812.4NOD2, CTSG, TNF, CCL11
2prednisolone44 28 1113.4NOD2, IL2, TNF, CCL11
3indomethacin44 59 28 1114.3CCL11, TNF, CTSG, IL2
4pranlukast44 28 1113.2CCL11, TNF, MUC2
5il 104411.2TNF, IL2, NOD2
6n-formylmethionyl-leucylphenylalanine4411.2CTSG, TNF, CCL11
7histamine44 28 2413.2CCL11, TNF, CTSG, IL2
8leukotriene b444 59 2413.1CTSG, TNF, CCL11
9interferon gamma4411.0TNF, IL2
10piclamilast44 1112.0IL2, TNF
11lenalidomide44 1112.0TNF, IL2
12taurine chloramine4410.9TNF, IL2
13endotoxin4410.9CTSG
14actinomycin d4410.8CCL11, TNF, MUC2, IL2
15toxin-14410.8IL2, TNF
16salmeterol44 49 28 1113.8IL2, CCL11
17gold sodium thiomalate4410.7IL2, TNF

GO Terms for genes affiliated with Ulcerative Colitis

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16Gene Ontology
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Biological processes related to Ulcerative Colitis according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of growth of symbiont in hostGO:04413011.2NOD2, CTSG, TNF
2defense response to Gram-positive bacteriumGO:05083011.1NOD2, TNF, CARD9
3positive regulation of interleukin-6 productionGO:03275511.1CARD9, TNF, NOD2
4immune responseGO:00695511.1IL2, CTSG, TNFSF15, CCL11
5positive regulation of JNK cascadeGO:04633011.1NOD2, TNF, CARD9
6positive regulation of humoral immune response mediated by circulating immunoglobulinGO:00292510.9TNF, NOD2
7response to muramyl dipeptideGO:03249510.9NOD2, CARD9
8positive regulation of stress-activated MAPK cascadeGO:03287410.8CARD9, NOD2
9positive regulation of interleukin-17 productionGO:03274010.7IL2, NOD2
10response to exogenous dsRNAGO:04333010.5NOD2, CARD9

Molecular functions related to Ulcerative Colitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1CARD domain bindingGO:05070010.8NOD2, CARD9

Products for genes affiliated with Ulcerative Colitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Ulcerative Colitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet