MCID: ULC004
MIFTS: 63

Ulcerative Colitis malady

Gastrointestinal diseases category

Summaries for Ulcerative Colitis

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MedlinePlus:32 Ulcerative colitis (uc) is a disease that causes inflammation and sores, called ulcers, in the lining of the rectum and colon. it is one of a group of diseases called inflammatory bowel disease. uc can happen at any age, but it usually starts between the ages of 15 and 30. it tends to run in families. the most common symptoms are pain in the abdomen and blood or pus in diarrhea. other symptoms may include anemia severe tiredness weight loss loss of appetite bleeding from the rectum sores on the skin joint pain growth failure in children about half of people with uc have mild symptoms. doctors use blood tests, stool tests, colonoscopy or sigmoidoscopy, and imaging tests to diagnose uc. several types of drugs can help control it. some people have long periods of remission, when they are free of symptoms. in severe cases, doctors must remove the colon. nih: national institute of diabetes and digestive and kidney diseases

MalaCards based summary: Ulcerative Colitis, also known as inflammatory bowel disease, ulcerative colitis type, is related to crohn's disease and inflammatory bowel disease. An important gene associated with Ulcerative Colitis is IL2 (interleukin 2), and among its related pathways are Cytokine Network and IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types. The drugs azathioprine and sulfasalazine and the compounds interferon gamma and piclamilast have been mentioned in the context of this disorder. Affiliated tissues include colon, colon and testes.

Disease Ontology:9 A colitis that is predominantly confined to the mucosa located in colon and includes characteristic ulcers, or open sores.

Genetics Home Reference:21 Ulcerative colitis is a chronic disorder that affects the digestive system. This condition is characterized by abnormal inflammation of the inner surface of the rectum and colon, which make up most of the length of the large intestine. The inflammation usually causes open sores (ulcers) to develop in the large intestine. Ulcerative colitis usually appears between ages 15 and 30, although it can develop at any age. The inflammation tends to flare up multiple times throughout life, which causes recurring signs and symptoms.

Wikipedia:63 Ulcerative colitis (Colitis ulcerosa, UC) is a form of inflammatory bowel disease (IBD). Ulcerative... more...

Aliases & Classifications for Ulcerative Colitis

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Ulcerative Colitis, Aliases & Descriptions:

Name: Ulcerative Colitis 30 9 21 11 32 3 60
Inflammatory Bowel Disease, Ulcerative Colitis Type 21
Chronic Left-Sided Ulcerative Colitis 60
Left-Sided Ulcerative Colitis 9
Left Sided Ulcerative Colitis 60
 
Idiopathic Proctocolitis 21
Colitis Ulcerative 43
Colitis Gravis 21
Uc 21


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


External Ids:

Disease Ontology9 DOID:8577
ICD9CM27 556, 556.9
MeSH33 D003093
NCIt38 C2952
ICD1025 K51

Related Diseases for Ulcerative Colitis

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Graphical network of the top 20 diseases related to Ulcerative Colitis:



Diseases related to ulcerative colitis

Symptoms for Ulcerative Colitis

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Drugs & Therapeutics for Ulcerative Colitis

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Genetic Tests for Ulcerative Colitis

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Anatomical Context for Ulcerative Colitis

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MalaCards organs/tissues related to Ulcerative Colitis:

31
Colon, Testes, Neutrophil, Bone, Skin, T cells, Kidney, Liver, Bone marrow, Brain, Monocytes, Thyroid, Endothelial, B cells, Whole blood, Prostate, Myeloid, Appendix, Smooth muscle, Eye, Lymph node, Thymus, Lung, Pancreas, Breast

FMA organs/tissues related to Ulcerative Colitis:

14
Colon

LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Ulcerative Colitis:
id TissueAnatomical CompartmentCell Relevance
1 BoneBone MarrowBone Marrow Stromal Cells Potential therapeutic candidate

Animal Models for Ulcerative Colitis or affiliated genes

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Publications for Ulcerative Colitis

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Articles related to Ulcerative Colitis:

(show top 50)    (show all 2116)
idTitleAuthorsYear
1
Lipidomic Profiling in Inflammatory Bowel Disease: Comparison Between Ulcerative Colitis and Crohn's Disease. (25895111)
2015
2
The *1244 A>G polymorphism of MyD88 (rs7744) is closely associated with susceptibility to ulcerative colitis. (24189845)
2014
3
Effect of Probiotics on Inducing Remission and Maintaining Therapy in Ulcerative Colitis, Crohn's Disease, and Pouchitis: Meta-analysis of Randomized Controlled Trials. (24280877)
2014
4
Genome-wide association analysis in primary sclerosing cholangitis and ulcerative colitis identifies risk loci at GPR35 and TCF4. (22821403)
2013
5
Response to 'Altered secretion in the right colon during ulcerative colitis: is it due to disease or to 5-ASA?'. (23480343)
2013
6
Long-term treatment of patients with a history of ulcerative colitis who develop gastritis and pan-enteritis after colectomy. (22858512)
2013
7
Comparison of QD and TID oral mesalazine for maintenance of remission in quiescent ulcerative colitis: a double-blind, double-dummy, randomized multicenter study. (23624890)
2013
8
Mucosal barrier in ulcerative colitis and Crohn's disease. (23737764)
2013
9
The characteristics of ulcerative colitis associated with autoimmune pancreatitis. (23426453)
2013
10
miR-20b, miR-98, miR-125b-1*, and let-7e* as new potential diagnostic biomarkers in ulcerative colitis. (23885139)
2013
11
Ulcerative colitis associated with extranodal marginal zone B-cell thyroid lymphoma of mucosa-associated lymphoid tissue and Hashimoto thyroiditis: description of a case. (24714310)
2013
12
Sternocostal involvement in chronic recurrent multifocal osteomyelitis associated with ulcerative colitis. (22961119)
2013
13
Management of difficult-to-treat patients with ulcerative colitis: focus on adalimumab. (23630414)
2013
14
Targeting sphingosine kinase 1 (SphK1) and apoptosis by colon-specific delivery formula of resveratrol in treatment of experimental ulcerative colitis in rats. (24055189)
2013
15
Gene expression of solute carrier family 9 (sodium/hydrogen exchanger) 3, (SLC9A3) is downregulated in patients with ulcerative colitis. (22447429)
2012
16
Temporal trends in colon neoplasms in patients with primary sclerosing cholangitis and ulcerative colitis. (22398080)
2012
17
Functional MICA-129 polymorphism and serum levels of soluble MICA are correlated with ulcerative colitis in Chinese patients. (21155878)
2011
18
Altered O-glycosylation profile of MUC2 mucin occurs in active ulcerative colitis and is associated with increased inflammation. (21290483)
2011
19
High-dose ursodeoxycholic acid is associated with the development of colorectal neoplasia in patients with ulcerative colitis and primary sclerosing cholangitis. (21556038)
2011
20
Genetic predictors of medically refractory ulcerative colitis. (20848476)
2010
21
R72P polymorphism of TP53 in ulcerative colitis patients is associated with the incidence of colectomy, use of steroids and the presence of a positive family history. (20309662)
2010
22
MICB0106 gene polymorphism is associated with ulcerative colitis in central China. (19662431)
2010
23
Methylation status of genes in non-neoplastic mucosa from patients with ulcerative colitis-associated colorectal cancer. (20160714)
2010
24
Epidemiology and gene markers of ulcerative colitis in the Chinese. (19230040)
2009
25
Fecal proteases from diarrheic-IBS and ulcerative colitis patients exert opposite effect on visceral sensitivity in mice. (19450926)
2009
26
Cerebral venous sinus thrombosis as presenting feature of ulcerative colitis. (19902870)
2009
27
Different regulation of eosinophil activity in Crohn's disease compared with ulcerative colitis. (18801925)
2008
28
Heterozygosity for IL23R p.Arg381Gln confers a protective effect not only against Crohn's disease but also ulcerative colitis. (17877509)
2007
29
Thrombophilic abnormalities of natural anticoagulants in patients with ulcerative colitis. (17708267)
2007
30
Comparative study of eosinophil chemotaxis, adhesion, and degranulation in vitro in ulcerative colitis and Crohn's disease. (17206716)
2007
31
Low detoxification capacity in the ileal pouch mucosa of patients with ulcerative colitis. (16432375)
2006
32
Association of CTLA-4 gene microsatellite polymorphism with ulcerative colitis in Chinese patients. (16670525)
2006
33
Proteasome-mediated degradation of IkappaBalpha and processing of p105 in Crohn disease and ulcerative colitis. (17124531)
2006
34
Genetic markers linked to rheumatoid arthritis are also strongly associated with articular manifestations in ulcerative colitis patients. (16720213)
2006
35
Takayasu's arteritis and ulcerative colitis in a young non-Asian woman: a rare association. (16363285)
2005
36
Susceptibility to refractory ulcerative colitis is associated with polymorphism in the hMLH1 mismatch repair gene. (15626886)
2004
37
Abnormal p53 immunohistochemistry is associated with an increased colorectal cancer-related mortality in patients with ulcerative colitis. (12818291)
2003
38
Effect of antisecretory factor in ulcerative colitis on histological and laborative outcome: a short period clinical trial. (14621278)
2003
39
Inducible and constitutive beta-defensins are differentially expressed in Crohn's disease and ulcerative colitis. (12902844)
2003
40
Abnormal motility in patients with ulcerative colitis: the role of inflammatory cytokines. (11926949)
2002
41
Efficacy of anti-tumor necrosis factor therapy in patients with ulcerative colitis. (12385442)
2002
42
Nephronophthisis and ulcerative colitis in siblings: a new association. (11420917)
2001
43
Functional and ethnic association of allele 2 of the interleukin-1 receptor antagonist gene in ulcerative colitis. (10500062)
1999
44
Application of IL-1 beta and 8 mRNA and some other indices in monitoring the activity of ulcerative colitis]. (12567438)
1999
45
Antioxidants inhibit the in vitro production of inflammatory cytokines in Crohn's disease and ulcerative colitis. (9541129)
1998
46
Surgery for pediatric ulcerative colitis. (7663621)
1995
47
Transient protein S deficiency associated with cerebral venous thrombosis in active ulcerative colitis. (7847309)
1995
48
Crohn's disease, ulcerative colitis, and normal intestinal lymphocytes express integrins in dissimilar patterns. (7523224)
1994
49
Anti-lactoferrin antibodies and other types of ANCA in ulcerative colitis, primary sclerosing cholangitis, and Crohn's disease. (8432453)
1993
50
Resolution of amyloidosis (AA type) complicating chronic ulcerative colitis. (3396825)
1988

Variations for Ulcerative Colitis

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Expression for genes affiliated with Ulcerative Colitis

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LifeMap Discovery
Genes differentially expressed in tissues of Ulcerative Colitis patients vs. healthy controls: 30 (show all 12)
id Gene Description Tissue Up/Dn Fold Change (log2) P value
1CLDN8claudin 8Colon-4.720.000
2LCN2lipocalin 2Colon+4.600.000
3REG3Aregenerating islet-derived 3 alphaColon+4.410.001
4SLC26A2solute carrier family 26 (anion exchanger), member 2Colon-4.190.000
5PCK1phosphoenolpyruvate carboxykinase 1 (soluble)Colon-4.130.000
6IL8interleukin 8Colon+3.860.003
7CXCL2chemokine (C-X-C motif) ligand 2Colon+3.850.000
8REG1Aregenerating islet-derived 1 alphaColon+3.680.005
9RGS3regulator of G-protein signaling 3Colon+3.580.000
10CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)Colon+3.550.000
11OLFM4olfactomedin 4Colon+3.250.014
12DEFA6defensin, alpha 6, Paneth cell-specificColon+3.220.003

Search GEO for disease gene expression data for Ulcerative Colitis.

Pathways for genes affiliated with Ulcerative Colitis

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Compounds for genes affiliated with Ulcerative Colitis

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Compounds related to Ulcerative Colitis according to GeneCards Suite gene sharing:

(show all 24)
idCompoundScoreTop Affiliating Genes
1interferon gamma4310.5IL2, TNF
2piclamilast43 1211.5IL2, TNF
3lenalidomide43 1211.5TNF, IL2
4taurine chloramine4310.5TNF, IL2
5toxin-14310.5IL2, TNF
6gold sodium thiomalate4310.5IL2, TNF
7pranlukast43 28 1212.5TNF, CCL11
8salmeterol43 49 28 1213.5IL2, CCL11
9il-124310.5IL2, TNF
10okt34310.4IL2, TNF
11groalpha4310.4CCL11, TNF
12gm-csf43 2811.4TNF, IL2
13triptolide4310.3TNF, IL2
14prednisolone43 28 1212.3IL2, CCL11, TNF
15budesonide43 49 1212.3CCL11, TNF
16herbimycin a43 5911.3TNF, CCL11, IL2
17ionomycin4310.3IL2, CCL11, TNF
18tacrolimus43 49 1212.3TNF, CCL11, IL2
19fluticasone propionate43 49 59 1213.2CCL11, TNF
202,5-oligoadenylate4310.2TNF, IL2
21rantes4310.1TNF, CCL11, IL2
22polyinosinic-polycytidylic acid4310.1TNF, IL2
23indomethacin43 28 59 1213.0IL2, CCL11, TNF
24rolipram43 59 2811.9CCL11, TNF

GO Terms for genes affiliated with Ulcerative Colitis

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Biological processes related to Ulcerative Colitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of interferon-gamma productionGO:003272910.2IL2, TNF

Products for genes affiliated with Ulcerative Colitis

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  • Antibodies
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  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Ulcerative Colitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet