UC
MCID: ULC004
MIFTS: 63

Ulcerative Colitis (UC) malady

Gastrointestinal diseases category

Summaries for Ulcerative Colitis

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Sources:
22Genetics Home Reference, 35MedlinePlus, 4CDC, 66Wikipedia, 48OMIM, 34MalaCards
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MedlinePlus:35 Ulcerative colitis (uc) is a disease that causes inflammation and sores, called ulcers, in the lining of the rectum and colon. it is one of a group of diseases called inflammatory bowel disease. uc can happen at any age, but it usually starts between the ages of 15 and 30. it tends to run in families. the most common symptoms are pain in the abdomen and blood or pus in diarrhea. other symptoms may include anemia severe tiredness weight loss loss of appetite bleeding from the rectum sores on the skin joint pain growth failure in children about half of people with uc have mild symptoms. doctors use blood tests, stool tests, colonoscopy or sigmoidoscopy, and imaging tests to diagnose uc. several types of drugs can help control it. some people have long periods of remission, when they are free of symptoms. in severe cases, doctors must remove the colon. nih: national institute of diabetes and digestive and kidney diseases

MalaCards: Ulcerative Colitis, also known as idiopathic proctocolitis, is related to crohn's disease and inflammatory bowel disease. An important gene associated with Ulcerative Colitis is IL2 (interleukin 2), and among its related pathways are Cytokines and Inflammatory Response and Immune response MIF mediated glucocorticoid regulation. The drugs azathioprine and hydrocortisone and the compounds interferon gamma and piclamilast have been mentioned in the context of this disorder. Affiliated tissues include colon, testes and skin.

Genetics Home Reference:22 Ulcerative colitis is a chronic disorder that affects the digestive system. This condition is characterized by abnormal inflammation of the inner surface of the rectum and colon, which make up most of the length of the large intestine. The inflammation usually causes open sores (ulcers) to develop in the large intestine. Ulcerative colitis usually appears between ages 15 and 30, although it can develop at any age. The inflammation tends to flare up multiple times throughout life, which causes recurring signs and symptoms.

CDC:4 Inflammatory Bowel Diseases (IBD) is a broad term that describes conditions with chronic or recurring immune response and inflammation of the gastrointestinal tract. The two most common inflammatory bowel diseases are ulcerative colitis and Crohnā€™s disease.

Wikipedia:66 Ulcerative colitis (Colitis ulcerosa, UC) is a form of inflammatory bowel disease (IBD). Ulcerative... more...

Description from OMIM:48 266600

Aliases & Classifications for Ulcerative Colitis

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9Disease Ontology, 22Genetics Home Reference, 11DISEASES, 35MedlinePlus, 32LifeMap Discoveryā„¢, 63UMLS, 46Novoseek, 59SNOMED-CT, 41NCIt, 28ICD9CM, 36MeSH, 48OMIM, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

ulcerative colitis 9 22 11 35 32 63
idiopathic proctocolitis 22 63
inflammatory bowel disease, ulcerative colitis type 22
chronic left-sided ulcerative colitis 63
left-sided ulcerative colitis 9
colitis ulcerative 46
colitis gravis 22
uc 22


External Ids:

Disease Ontology9 DOID:8577
NCIt41 C2952
ICD9CM28 556, 556.9
MeSH36 D003093
OMIM48 266600
ICD1026 K51

Related Diseases for Ulcerative Colitis

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18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Ulcerative Colitis:



Diseases related to ulcerative colitis

Symptoms for Ulcerative Colitis

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48OMIM
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Clinical features from OMIM:

266600

Drugs & Therapeutics for Ulcerative Colitis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 32LifeMap Discoveryā„¢, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Ulcerative Colitis

Drug clinical trials:

Search ClinicalTrials for Ulcerative Colitis

Search NIH Clinical Center for Ulcerative Colitis

Search CenterWatch for Ulcerative Colitis

Inferred drug relations via UMLS63/NDF-RT42:

Show with subtypes

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Ulcerative Colitis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Ulcerative Colitis:
MultiStem
Embryonic/Adult Cultured Cells Related to Ulcerative Colitis:
Bone marrow-derived adherent progenitor cells (MultiStem)

Genetic Tests for Ulcerative Colitis

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Anatomical Context for Ulcerative Colitis

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32LifeMap Discoveryā„¢, 34MalaCards
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MalaCards organs/tissues related to Ulcerative Colitis:

34
Colon, Testes, Skin, Kidney, T cells, Bone, Liver, Monocytes, Bone marrow, Endothelial, Thyroid, B cells, Myeloid, Appendix, Whole blood, Smooth muscle, Thymus, Eye, Breast, Lung, Pancreas, Prostate, Lymph node

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Ulcerative Colitis:
id TissueAnatomical CompartmentCell Relevance
1 BoneBone MarrowBone Marrow Stromal Cells Potential therapeutic candidate

Animal Models for Ulcerative Colitis or affiliated genes

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Publications for Ulcerative Colitis

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53PubMed
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Articles related to Ulcerative Colitis:

(show top 50)    (show all 1993)
idTitleAuthorsYear
1
The *1244 A>G polymorphism of MyD88 (rs7744) is closely associated with susceptibility to ulcerative colitis. (24189845)
2014
2
Effect of Probiotics on Inducing Remission and Maintaining Therapy in Ulcerative Colitis, Crohn's Disease, and Pouchitis: Meta-analysis of Randomized Controlled Trials. (24280877)
2014
3
Genome-wide association analysis in primary sclerosing cholangitis and ulcerative colitis identifies risk loci at GPR35 and TCF4. (22821403)
2013
4
Response to 'Altered secretion in the right colon during ulcerative colitis: is it due to disease or to 5-ASA?'. (23480343)
2013
5
Long-term treatment of patients with a history of ulcerative colitis who develop gastritis and pan-enteritis after colectomy. (22858512)
2013
6
Comparison of QD and TID oral mesalazine for maintenance of remission in quiescent ulcerative colitis: a double-blind, double-dummy, randomized multicenter study. (23624890)
2013
7
Mucosal barrier in ulcerative colitis and Crohn's disease. (23737764)
2013
8
The characteristics of ulcerative colitis associated with autoimmune pancreatitis. (23426453)
2013
9
miR-20b, miR-98, miR-125b-1*, and let-7e* as new potential diagnostic biomarkers in ulcerative colitis. (23885139)
2013
10
Sternocostal involvement in chronic recurrent multifocal osteomyelitis associated with ulcerative colitis. (22961119)
2013
11
Management of difficult-to-treat patients with ulcerative colitis: focus on adalimumab. (23630414)
2013
12
Targeting sphingosine kinase 1 (SphK1) and apoptosis by colon-specific delivery formula of resveratrol in treatment of experimental ulcerative colitis in rats. (24055189)
2013
13
Gene expression of solute carrier family 9 (sodium/hydrogen exchanger) 3, (SLC9A3) is downregulated in patients with ulcerative colitis. (22447429)
2012
14
Temporal trends in colon neoplasms in patients with primary sclerosing cholangitis and ulcerative colitis. (22398080)
2012
15
Refractory pyoderma gangrenosum associated with ulcerative colitis successfully treated with infliximab. (22301049)
2012
16
Functional MICA-129 polymorphism and serum levels of soluble MICA are correlated with ulcerative colitis in Chinese patients. (21155878)
2011
17
Altered O-glycosylation profile of MUC2 mucin occurs in active ulcerative colitis and is associated with increased inflammation. (21290483)
2011
18
High-dose ursodeoxycholic acid is associated with the development of colorectal neoplasia in patients with ulcerative colitis and primary sclerosing cholangitis. (21556038)
2011
19
Genetic predictors of medically refractory ulcerative colitis. (20848476)
2010
20
R72P polymorphism of TP53 in ulcerative colitis patients is associated with the incidence of colectomy, use of steroids and the presence of a positive family history. (20309662)
2010
21
MICB0106 gene polymorphism is associated with ulcerative colitis in central China. (19662431)
2010
22
Methylation status of genes in non-neoplastic mucosa from patients with ulcerative colitis-associated colorectal cancer. (20160714)
2010
23
Epidemiology and gene markers of ulcerative colitis in the Chinese. (19230040)
2009
24
Fecal proteases from diarrheic-IBS and ulcerative colitis patients exert opposite effect on visceral sensitivity in mice. (19450926)
2009
25
Cerebral venous sinus thrombosis as presenting feature of ulcerative colitis. (19902870)
2009
26
Different regulation of eosinophil activity in Crohn's disease compared with ulcerative colitis. (18801925)
2008
27
Heterozygosity for IL23R p.Arg381Gln confers a protective effect not only against Crohn's disease but also ulcerative colitis. (17877509)
2007
28
Thrombophilic abnormalities of natural anticoagulants in patients with ulcerative colitis. (17708267)
2007
29
Comparative study of eosinophil chemotaxis, adhesion, and degranulation in vitro in ulcerative colitis and Crohn's disease. (17206716)
2007
30
Low detoxification capacity in the ileal pouch mucosa of patients with ulcerative colitis. (16432375)
2006
31
Association of CTLA-4 gene microsatellite polymorphism with ulcerative colitis in Chinese patients. (16670525)
2006
32
Proteasome-mediated degradation of IkappaBalpha and processing of p105 in Crohn disease and ulcerative colitis. (17124531)
2006
33
Genetic markers linked to rheumatoid arthritis are also strongly associated with articular manifestations in ulcerative colitis patients. (16720213)
2006
34
Takayasu's arteritis and ulcerative colitis in a young non-Asian woman: a rare association. (16363285)
2005
35
Susceptibility to refractory ulcerative colitis is associated with polymorphism in the hMLH1 mismatch repair gene. (15626886)
2004
36
Abnormal p53 immunohistochemistry is associated with an increased colorectal cancer-related mortality in patients with ulcerative colitis. (12818291)
2003
37
Effect of antisecretory factor in ulcerative colitis on histological and laborative outcome: a short period clinical trial. (14621278)
2003
38
Inducible and constitutive beta-defensins are differentially expressed in Crohn's disease and ulcerative colitis. (12902844)
2003
39
Gelatinase A (MMP-2), collagenase-2 (MMP-8), and laminin-5 gamma2-chain expression in murine inflammatory bowel disease (ulcerative colitis). (12645796)
2003
40
Abnormal motility in patients with ulcerative colitis: the role of inflammatory cytokines. (11926949)
2002
41
Efficacy of anti-tumor necrosis factor therapy in patients with ulcerative colitis. (12385442)
2002
42
Ulcerative colitis after statin treatment. (12151572)
2002
43
Nephronophthisis and ulcerative colitis in siblings: a new association. (11420917)
2001
44
Functional and ethnic association of allele 2 of the interleukin-1 receptor antagonist gene in ulcerative colitis. (10500062)
1999
45
Application of IL-1 beta and 8 mRNA and some other indices in monitoring the activity of ulcerative colitis]. (12567438)
1999
46
Surgery for pediatric ulcerative colitis. (7663621)
1995
47
Transient protein S deficiency associated with cerebral venous thrombosis in active ulcerative colitis. (7847309)
1995
48
Crohn's disease, ulcerative colitis, and normal intestinal lymphocytes express integrins in dissimilar patterns. (7523224)
1994
49
Anti-lactoferrin antibodies and other types of ANCA in ulcerative colitis, primary sclerosing cholangitis, and Crohn's disease. (8432453)
1993
50
Resolution of amyloidosis (AA type) complicating chronic ulcerative colitis. (3396825)
1988

Variations for Ulcerative Colitis

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Expression for genes affiliated with Ulcerative Colitis

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Ulcerative Colitis

Search GEO for disease gene expression data for Ulcerative Colitis.

Pathways for genes affiliated with Ulcerative Colitis

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51PathCards, 39NCBI BioSystems Database, 61Thomson Reuters, 54QIAGEN, 55R&D Systems, 31KEGG
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Compounds for genes affiliated with Ulcerative Colitis

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46Novoseek, 12DrugBank, 30IUPHAR, 52PharmGKB, 62Tocris Bioscience
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Compounds related to Ulcerative Colitis according to GeneCards/GeneDecks:

(show all 24)
idCompoundScoreTop Affiliating Genes
1interferon gamma4610.5IL2, TNF
2piclamilast46 1211.5IL2, TNF
3lenalidomide46 1211.5TNF, IL2
4taurine chloramine4610.5TNF, IL2
5toxin-14610.5IL2, TNF
6gold sodium thiomalate4610.5IL2, TNF
7pranlukast46 30 1212.5TNF, CCL11
8salmeterol46 52 30 1213.5IL2, CCL11
9il-124610.5IL2, TNF
10okt34610.4IL2, TNF
11groalpha4610.4CCL11, TNF
12gm-csf46 3011.4TNF, IL2
13triptolide4610.3TNF, IL2
14prednisolone46 30 1212.3IL2, CCL11, TNF
15budesonide46 52 1212.3CCL11, TNF
16herbimycin a46 6211.3TNF, CCL11, IL2
17ionomycin4610.3IL2, CCL11, TNF
18tacrolimus46 52 1212.3TNF, CCL11, IL2
19fluticasone propionate46 52 62 1213.2CCL11, TNF
202,5-oligoadenylate4610.2TNF, IL2
21rantes4610.1TNF, CCL11, IL2
22polyinosinic-polycytidylic acid4610.1TNF, IL2
23indomethacin46 30 62 1213.0IL2, CCL11, TNF
24rolipram46 62 3011.9CCL11, TNF

GO Terms for genes affiliated with Ulcerative Colitis

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17Gene Ontology
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Biological processes related to Ulcerative Colitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of interferon-gamma productionGO:03272910.2IL2, TNF

Products for genes affiliated with Ulcerative Colitis

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Sources for Ulcerative Colitis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet