UC
MCID: ULC004
MIFTS: 64

Ulcerative Colitis (UC) malady

Gastrointestinal diseases category

Summaries for Ulcerative Colitis

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MedlinePlus:33 Ulcerative colitis (uc) is a disease that causes inflammation and sores, called ulcers, in the lining of the rectum and colon. it is one of a group of diseases called inflammatory bowel disease. uc can happen at any age, but it usually starts between the ages of 15 and 30. it tends to run in families. the most common symptoms are pain in the abdomen and blood or pus in diarrhea. other symptoms may include anemia severe tiredness weight loss loss of appetite bleeding from the rectum sores on the skin joint pain growth failure in children about half of people with uc have mild symptoms. doctors use blood tests, stool tests, colonoscopy or sigmoidoscopy, and imaging tests to diagnose uc. several types of drugs can help control it. some people have long periods of remission, when they are free of symptoms. in severe cases, doctors must remove the colon. nih: national institute of diabetes and digestive and kidney diseases

MalaCards based summary: Ulcerative Colitis, also known as idiopathic proctocolitis, is related to crohn's disease and inflammatory bowel disease. An important gene associated with Ulcerative Colitis is IL2 (interleukin 2), and among its related pathways are Cytokines and Inflammatory Response and Immune response MIF mediated glucocorticoid regulation. The drugs hydrocortisone and hydrocortisone probutate and the compounds interferon gamma and piclamilast have been mentioned in the context of this disorder. Affiliated tissues include colon, colon and testes.

Disease Ontology:9 A colitis that is predominantly confined to the mucosa located in colon and includes characteristic ulcers, or open sores.

Genetics Home Reference:22 Ulcerative colitis is a chronic disorder that affects the digestive system. This condition is characterized by abnormal inflammation of the inner surface of the rectum and colon, which make up most of the length of the large intestine. The inflammation usually causes open sores (ulcers) to develop in the large intestine. Ulcerative colitis usually appears between ages 15 and 30, although it can develop at any age. The inflammation tends to flare up multiple times throughout life, which causes recurring signs and symptoms.

Wikipedia:64 Ulcerative colitis (Colitis ulcerosa, UC) is a form of inflammatory bowel disease (IBD). Ulcerative... more...

Description from OMIM:46 266600

Aliases & Classifications for Ulcerative Colitis

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Ulcerative Colitis, Aliases & Descriptions:

Name: Ulcerative Colitis 31 9 22 11 33 61
Idiopathic Proctocolitis 22 61
Inflammatory Bowel Disease, Ulcerative Colitis Type 22
Chronic Left-Sided Ulcerative Colitis 61
 
Left-Sided Ulcerative Colitis 9
Colitis Ulcerative 44
Colitis Gravis 22
Uc 22


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


External Ids:

Disease Ontology9 DOID:8577
ICD9CM28 556, 556.9
OMIM46 266600
MeSH34 D003093
NCIt39 C2952
ICD1026 K51

Related Diseases for Ulcerative Colitis

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Graphical network of the top 20 diseases related to Ulcerative Colitis:



Diseases related to ulcerative colitis

Symptoms for Ulcerative Colitis

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Clinical features from OMIM:

266600

Drugs & Therapeutics for Ulcerative Colitis

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Genetic Tests for Ulcerative Colitis

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Anatomical Context for Ulcerative Colitis

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MalaCards organs/tissues related to Ulcerative Colitis:

32
Colon, Testes, Neutrophil, Skin, T cells, Kidney, Bone, Liver, Monocytes, Bone marrow, Thyroid, Endothelial, B cells, Whole blood, Myeloid, Appendix, Smooth muscle, Eye, Lymph node, Thymus, Lung, Pancreas, Breast, Prostate

FMA organs/tissues related to Ulcerative Colitis:

15
Colon

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Ulcerative Colitis:
id TissueAnatomical CompartmentCell Relevance
1 BoneBone MarrowBone Marrow Stromal Cells Potential therapeutic candidate

Animal Models for Ulcerative Colitis or affiliated genes

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Publications for Ulcerative Colitis

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Articles related to Ulcerative Colitis:

(show top 50)    (show all 2079)
idTitleAuthorsYear
1
The *1244 A>G polymorphism of MyD88 (rs7744) is closely associated with susceptibility to ulcerative colitis. (24189845)
2014
2
Effect of Probiotics on Inducing Remission and Maintaining Therapy in Ulcerative Colitis, Crohn's Disease, and Pouchitis: Meta-analysis of Randomized Controlled Trials. (24280877)
2014
3
Genome-wide association analysis in primary sclerosing cholangitis and ulcerative colitis identifies risk loci at GPR35 and TCF4. (22821403)
2013
4
Response to 'Altered secretion in the right colon during ulcerative colitis: is it due to disease or to 5-ASA?'. (23480343)
2013
5
Long-term treatment of patients with a history of ulcerative colitis who develop gastritis and pan-enteritis after colectomy. (22858512)
2013
6
Comparison of QD and TID oral mesalazine for maintenance of remission in quiescent ulcerative colitis: a double-blind, double-dummy, randomized multicenter study. (23624890)
2013
7
Mucosal barrier in ulcerative colitis and Crohn's disease. (23737764)
2013
8
The characteristics of ulcerative colitis associated with autoimmune pancreatitis. (23426453)
2013
9
miR-20b, miR-98, miR-125b-1*, and let-7e* as new potential diagnostic biomarkers in ulcerative colitis. (23885139)
2013
10
Ulcerative colitis associated with extranodal marginal zone B-cell thyroid lymphoma of mucosa-associated lymphoid tissue and Hashimoto thyroiditis: description of a case. (24714310)
2013
11
Sternocostal involvement in chronic recurrent multifocal osteomyelitis associated with ulcerative colitis. (22961119)
2013
12
Management of difficult-to-treat patients with ulcerative colitis: focus on adalimumab. (23630414)
2013
13
Targeting sphingosine kinase 1 (SphK1) and apoptosis by colon-specific delivery formula of resveratrol in treatment of experimental ulcerative colitis in rats. (24055189)
2013
14
Gene expression of solute carrier family 9 (sodium/hydrogen exchanger) 3, (SLC9A3) is downregulated in patients with ulcerative colitis. (22447429)
2012
15
Temporal trends in colon neoplasms in patients with primary sclerosing cholangitis and ulcerative colitis. (22398080)
2012
16
Functional MICA-129 polymorphism and serum levels of soluble MICA are correlated with ulcerative colitis in Chinese patients. (21155878)
2011
17
Altered O-glycosylation profile of MUC2 mucin occurs in active ulcerative colitis and is associated with increased inflammation. (21290483)
2011
18
High-dose ursodeoxycholic acid is associated with the development of colorectal neoplasia in patients with ulcerative colitis and primary sclerosing cholangitis. (21556038)
2011
19
Genetic predictors of medically refractory ulcerative colitis. (20848476)
2010
20
R72P polymorphism of TP53 in ulcerative colitis patients is associated with the incidence of colectomy, use of steroids and the presence of a positive family history. (20309662)
2010
21
MICB0106 gene polymorphism is associated with ulcerative colitis in central China. (19662431)
2010
22
Methylation status of genes in non-neoplastic mucosa from patients with ulcerative colitis-associated colorectal cancer. (20160714)
2010
23
Epidemiology and gene markers of ulcerative colitis in the Chinese. (19230040)
2009
24
Fecal proteases from diarrheic-IBS and ulcerative colitis patients exert opposite effect on visceral sensitivity in mice. (19450926)
2009
25
Cerebral venous sinus thrombosis as presenting feature of ulcerative colitis. (19902870)
2009
26
Different regulation of eosinophil activity in Crohn's disease compared with ulcerative colitis. (18801925)
2008
27
Heterozygosity for IL23R p.Arg381Gln confers a protective effect not only against Crohn's disease but also ulcerative colitis. (17877509)
2007
28
Thrombophilic abnormalities of natural anticoagulants in patients with ulcerative colitis. (17708267)
2007
29
Comparative study of eosinophil chemotaxis, adhesion, and degranulation in vitro in ulcerative colitis and Crohn's disease. (17206716)
2007
30
Low detoxification capacity in the ileal pouch mucosa of patients with ulcerative colitis. (16432375)
2006
31
Association of CTLA-4 gene microsatellite polymorphism with ulcerative colitis in Chinese patients. (16670525)
2006
32
Proteasome-mediated degradation of IkappaBalpha and processing of p105 in Crohn disease and ulcerative colitis. (17124531)
2006
33
Genetic markers linked to rheumatoid arthritis are also strongly associated with articular manifestations in ulcerative colitis patients. (16720213)
2006
34
Takayasu's arteritis and ulcerative colitis in a young non-Asian woman: a rare association. (16363285)
2005
35
Susceptibility to refractory ulcerative colitis is associated with polymorphism in the hMLH1 mismatch repair gene. (15626886)
2004
36
Abnormal p53 immunohistochemistry is associated with an increased colorectal cancer-related mortality in patients with ulcerative colitis. (12818291)
2003
37
Effect of antisecretory factor in ulcerative colitis on histological and laborative outcome: a short period clinical trial. (14621278)
2003
38
Inducible and constitutive beta-defensins are differentially expressed in Crohn's disease and ulcerative colitis. (12902844)
2003
39
Gelatinase A (MMP-2), collagenase-2 (MMP-8), and laminin-5 gamma2-chain expression in murine inflammatory bowel disease (ulcerative colitis). (12645796)
2003
40
Abnormal motility in patients with ulcerative colitis: the role of inflammatory cytokines. (11926949)
2002
41
Efficacy of anti-tumor necrosis factor therapy in patients with ulcerative colitis. (12385442)
2002
42
Nephronophthisis and ulcerative colitis in siblings: a new association. (11420917)
2001
43
Functional and ethnic association of allele 2 of the interleukin-1 receptor antagonist gene in ulcerative colitis. (10500062)
1999
44
Application of IL-1 beta and 8 mRNA and some other indices in monitoring the activity of ulcerative colitis]. (12567438)
1999
45
Antioxidants inhibit the in vitro production of inflammatory cytokines in Crohn's disease and ulcerative colitis. (9541129)
1998
46
Surgery for pediatric ulcerative colitis. (7663621)
1995
47
Transient protein S deficiency associated with cerebral venous thrombosis in active ulcerative colitis. (7847309)
1995
48
Crohn's disease, ulcerative colitis, and normal intestinal lymphocytes express integrins in dissimilar patterns. (7523224)
1994
49
Anti-lactoferrin antibodies and other types of ANCA in ulcerative colitis, primary sclerosing cholangitis, and Crohn's disease. (8432453)
1993
50
Resolution of amyloidosis (AA type) complicating chronic ulcerative colitis. (3396825)
1988

Variations for Ulcerative Colitis

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Expression for genes affiliated with Ulcerative Colitis

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets, 31LifeMap Discovery®
See all sources
LifeMap Discovery
Genes differentially expressed in tissues of Ulcerative Colitis patients vs. healthy controls: 31 (show all 85)
id Gene Description Tissue Up/Dn Fold Change (log2) P value
1CLDN8claudin 8Colon-4.720.000
2LCN2lipocalin 2Colon+4.600.000
3REG3Aregenerating islet-derived 3 alphaColon+4.410.001
4SLC26A2solute carrier family 26 (anion exchanger), member 2Colon-4.190.000
5PCK1phosphoenolpyruvate carboxykinase 1 (soluble)Colon-4.130.000
6IL8interleukin 8Colon+3.860.003
7CXCL2chemokine (C-X-C motif) ligand 2Colon+3.850.000
8REG1Aregenerating islet-derived 1 alphaColon+3.680.005
9RGS3regulator of G-protein signaling 3Colon+3.580.000
10CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)Colon+3.550.000
11OLFM4olfactomedin 4Colon+3.250.014
12DEFA6defensin, alpha 6, Paneth cell-specificColon+3.220.003
13GUCA2Aguanylate cyclase activator 2A (guanylin)Colon-2.850.010
14MMP12matrix metallopeptidase 12 (macrophage elastase)Colon+2.810.001
15ABCB1ATP-binding cassette, sub-family B (MDR/TAP), member 1Colon-2.780.008
16AQP8aquaporin 8Colon-2.770.001
17CD55CD55 molecule, decay accelerating factor for complement (Cromer blood group)Colon+2.680.000
18CXCL11chemokine (C-X-C motif) ligand 11Colon+2.610.000
19S100A9S100 calcium binding protein A9Colon+2.560.010
20MMP9matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)Colon+2.520.021
21SERPINB5serpin peptidase inhibitor, clade B (ovalbumin), member 5Colon+2.430.043
22DEFA5defensin, alpha 5, Paneth cell-specificColon+2.340.008
23NOS2nitric oxide synthase 2, inducibleColon+2.330.004
24PDZK1IP1PDZK1 interacting protein 1Colon+2.270.001
25SLC4A4solute carrier family 4 (sodium bicarbonate cotransporter), member 4Colon-2.240.000
26ABCA8ATP-binding cassette, sub-family A (ABC1), member 8Colon-2.210.002
27SATB2SATB homeobox 2Colon-2.200.006
28PI3peptidase inhibitor 3, skin-derivedColon+2.200.006
29CXCL3chemokine (C-X-C motif) ligand 3Colon+2.190.006
30CXCL13chemokine (C-X-C motif) ligand 13Colon+2.190.021
31PTGDSprostaglandin D2 synthase 21kDa (brain)Colon+2.180.002
32EXPH5exophilin 5Colon-2.170.003
33ADAMDEC1ADAM-like, decysin 1Colon-2.170.003
34SPINK4serine peptidase inhibitor, Kazal type 4Colon+2.150.038
35ANK3ankyrin 3, node of Ranvier (ankyrin G)Colon-2.130.040
36SAA1serum amyloid A1Colon+2.090.046
37NR1D2nuclear receptor subfamily 1, group D, member 2Colon-2.060.005
38FRZBfrizzled-related proteinColon-2.040.013
39LPCAT1lysophosphatidylcholine acyltransferase 1Colon+2.030.000
40HAPLN1hyaluronan and proteoglycan link protein 1Colon-2.030.024
41PRKACBprotein kinase, cAMP-dependent, catalytic, betaColon-2.020.004
42ADD3adducin 3 (gamma)Colon-1.960.001
43PTPRRprotein tyrosine phosphatase, receptor type, RColon-1.950.030
44SLC16A1solute carrier family 16 (monocarboxylate transporter), member 1Colon-1.950.012
45RMND5Arequired for meiotic nuclear division 5 homolog A (S. cerevisiae)Colon-1.940.016
46CLUclusterinColon+1.930.024
47CD79ACD79a molecule, immunoglobulin-associated alphaColon+1.890.022
48PLOD2procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2Colon-1.880.002
49SELENBP1selenium binding protein 1Colon-1.870.035
50BCL2A1BCL2-related protein A1Colon+1.870.040
51VPS13Avacuolar protein sorting 13 homolog A (S. cerevisiae)Colon-1.860.001
52POU2AF1POU class 2 associating factor 1Colon+1.840.002
53TSPAN7tetraspanin 7Colon-1.840.020
54BTG3BTG family, member 3Colon-1.800.002
55CORO1Acoronin, actin binding protein, 1AColon+1.740.032
56FSCN1fascin actin-bundling protein 1Colon+1.720.028
57CD27CD27 moleculeColon+1.710.013
58PSKH1protein serine kinase H1Colon+1.690.019
59COL6A3collagen, type VI, alpha 3Colon+1.690.048
60SOSTDC1sclerostin domain containing 1Colon-1.680.020
61PDK3pyruvate dehydrogenase kinase, isozyme 3Colon+1.660.013
62MXI1MAX interactor 1, dimerization proteinColon-1.650.000
63GUCA2Bguanylate cyclase activator 2B (uroguanylin)Colon-1.650.015
64PRKCIprotein kinase C, iotaColon-1.650.017
65NEDD4Lneural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligaseColon-1.650.020
66PANK3pantothenate kinase 3Colon-1.640.001
67ZC3H13zinc finger CCCH-type containing 13Colon-1.610.033
68IGFBP5insulin-like growth factor binding protein 5Colon+1.600.049
69LCP1lymphocyte cytosolic protein 1 (L-plastin)Colon+1.600.044
70HIST1H4Chistone cluster 1, H4cColon-1.570.035
71PIM2pim-2 oncogeneColon+1.570.048
72DMBT1deleted in malignant brain tumors 1Colon+1.560.042
73TIMP1TIMP metallopeptidase inhibitor 1Colon+1.540.024
74RSBN1round spermatid basic protein 1Colon-1.510.026
75ANKRD12ankyrin repeat domain 12Colon-1.490.032
76ARID5AAT rich interactive domain 5A (MRF1-like)Colon+1.470.032
77PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)Colon-1.460.039
78LGALS2lectin, galactoside-binding, soluble, 2Colon-1.460.044
79TSPAN6tetraspanin 6Colon-1.450.033
80BRINP3bone morphogenetic protein/retinoic acid inducible neural-specific 3Colon-1.420.002
81F2RL1coagulation factor II (thrombin) receptor-like 1Colon-1.400.025
82ENTPD5ectonucleoside triphosphate diphosphohydrolase 5Colon-1.400.020
83CFBcomplement factor BColon+1.330.010
84ICAM1intercellular adhesion molecule 1Colon+1.310.031
85CCNT2cyclin T2Colon-1.300.039

Expression patterns in normal tissues for genes affiliated with Ulcerative Colitis

Search GEO for disease gene expression data for Ulcerative Colitis.

Pathways for genes affiliated with Ulcerative Colitis

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Compounds for genes affiliated with Ulcerative Colitis

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Compounds related to Ulcerative Colitis according to GeneCards/GeneDecks:

(show all 24)
idCompoundScoreTop Affiliating Genes
1interferon gamma4410.5IL2, TNF
2piclamilast44 1211.5IL2, TNF
3lenalidomide44 1211.5TNF, IL2
4taurine chloramine4410.5TNF, IL2
5toxin-14410.5IL2, TNF
6gold sodium thiomalate4410.5IL2, TNF
7pranlukast44 29 1212.5TNF, CCL11
8salmeterol44 50 29 1213.5IL2, CCL11
9il-124410.5IL2, TNF
10okt34410.4IL2, TNF
11groalpha4410.4CCL11, TNF
12gm-csf44 2911.4TNF, IL2
13triptolide4410.3TNF, IL2
14prednisolone44 29 1212.3IL2, CCL11, TNF
15budesonide44 50 1212.3CCL11, TNF
16herbimycin a44 6011.3TNF, CCL11, IL2
17ionomycin4410.3IL2, CCL11, TNF
18tacrolimus44 50 1212.3TNF, CCL11, IL2
19fluticasone propionate44 50 60 1213.2CCL11, TNF
202,5-oligoadenylate4410.2TNF, IL2
21rantes4410.1TNF, CCL11, IL2
22polyinosinic-polycytidylic acid4410.1TNF, IL2
23indomethacin44 29 60 1213.0IL2, CCL11, TNF
24rolipram44 60 2911.9CCL11, TNF

GO Terms for genes affiliated with Ulcerative Colitis

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Biological processes related to Ulcerative Colitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of interferon-gamma productionGO:03272910.2IL2, TNF

Products for genes affiliated with Ulcerative Colitis

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Sources for Ulcerative Colitis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet