Ulcerative Colitis malady

MedlinePlus: Ulcerative colitis is a disease that causes ulcers in the lining of the rectum and colon. it is one of a group of diseases called inflammatory bowel disease. ulcers form where inflammation has killed the cells that usually line the colon. ulcerative colitis can happen at any age, but it usually starts between the ages of 15 and 30. it tends to run in families. the most common symptoms are pain in the abdomen and bloody diarrhea. other symptoms may include anemia, severe tiredness, weight loss, loss of appetite, bleeding from the rectum, sores on the skin and joint pain. children with the disease may have growth problems. about half of people with ulcerative colitis have mild symptoms. several types of drugs can help control ulcerative colitis. some people have long periods of remission, when they are free of symptoms. in severe cases, doctors must remove the colon. nih: national institute of diabetes and digestive and kidney diseases²³

MalaCards: Ulcerative Colitis, also known as inflammatory bowel disease, ulcerative colitis type, is related to carcinoma and inflammatory bowel disease. An important gene associated with Ulcerative Colitis is CLDN18 (claudin 18), and among its related pathways are Immune System and p38 Signaling. The drugs azathioprine and hydrocortisone probutate and the compounds calcium and atp have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, whole blood and lymph node, and related mouse phenotypes are mortality/aging and immune system.

Genetics Home Reference: Ulcerative colitis is a chronic disorder that affects the digestive system. This condition is characterized by abnormal inflammation of the inner surface of the rectum and colon, which make up most of the length of the large intestine. The inflammation usually causes open sores (ulcers) to develop in the large intestine. Ulcerative colitis usually appears between ages 15 and 30, although it can develop at any age. The inflammation tends to flare up multiple times throughout life, which causes recurring signs and symptoms.¹⁷

CDC: Inflammatory Bowel Diseases (IBD) is a broad term that describes conditions with chronic or recurring immune response and inflammation of the gastrointestinal tract. The two most common inflammatory bowel diseases are ulcerative colitis and Crohn’s disease.²

Wikipedia: Ulcerative colitis (Colitis ulcerosa, UC) is a form of inflammatory bowel disease (IBD). Ulcerative...⁴⁴ more...

Aliases & Descriptions:

ulcerative colitis 6 17 8 23 43 inflammatory bowel disease, ulcerative colitis type 17 chronic left-sided ulcerative colitis 43 left-sided ulcerative colitis 6 idiopathic proctocolitis 17

colitis ulcerative 32 colitis gravis 17 colitis 43 uc 17

Diseases related to ulcerative colitis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 951)

id	Related Disease	Score	Top Affiliating Genes
1	carcinoma	67.2	PIK3CA, PI3, LRP5, LRP6, KLF4, NCAM1
2	inflammatory bowel disease	53.4	PDE4A, REG4, GCG, SELE, SELL, SELP
3	leukemia	51.5	PIK3CA, LRP5, LRP6, KLF4, NCAM1, PDCD1
4	pancreatitis	50.0	PIK3CA, PI3, LRP5, KLF4, NCAM1, PDE4A
5	crohn's disease	49.0	WAS, GCG, BPI, BDKRB2, MUC2, MUC3A
6	prostatitis	48.4	PIK3CA, LRP5, KLF4, NCAM1, PDCD1, PDE4A
7	adenocarcinoma	47.3	PIK3CA, KLF4, NCAM1, REG1A, REG4, RELA
8	gastric cancer	44.4	PIK3CA, KLF4, REG1A, REG4, RELA, VWF
9	neuronitis	44.2	PIK3CA, LRP6, KLF4, NCAM1, PDE4A, REG1A
10	esophagitis	43.2	PIK3CA, KLF4, NCAM1, PDE4A, REG1A, RELA
11	thyroiditis	41.9	PIK3CA, KLF4, NCAM1, PDE4A, RELA, VWF
12	melanoma	41.8	PIK3CA, PI3, NCAM1, PDCD1, PDE4A, REL
13	psoriasis	41.5	PI3, PDE4A, CNR1, KIR2DL3, KIR3DL1, KIR2DS2
14	colon cancer	40.9	PIK3CA, LRP6, KLF4, NCAM1, PDE4A, REG1A
15	celiac disease	40.8	REG1A, REL, KIR3DL1, KIAA1109, SELE, SELL
16	cholangitis	40.8	REL, KIR3DL1, PCNA, BPI, BIRC5, CLDN1
17	cerebritis	40.1	LRP6, KLF4, NCAM1, PDE4A, REG1A, RELA
18	colon carcinoma	40.0	PIK3CA, KLF4, NCAM1, CNR1, SELE, SELL
19	adenoma	40.0	PIK3CA, KLF4, NCAM1, PDE4A, REG1A, REG4
20	sclerosing cholangitis	39.8	REL, KIR3DL1, BPI, CLDN1, CFTR, CEACAM3
21	pneumonia	39.4	PI3, PDE4A, RELA, SFTPD, SELE, SELL
22	fibrosis	39.1	PIK3CA, PI3, PDE4A, REG1A, RELA, CNR1
23	hepatocellular carcinoma	39.0	PIK3CA, NCAM1, PDCD1, REG1A, RELA, CNR1
24	spondylitis	38.4	PDCD1, RELA, KIR2DL3, KIR3DL1, KIR2DS2, KIR2DL2
25	cervicitis	38.3	PIK3CA, PDCD1, PDE4A, RELA, CNR1, KIR2DL3
26	colorectal cancer	36.5	NAT1, NAT2, VDR, MTHFR, MTR, MLH1
27	obesity	36.2	PIK3CA, LRP5, RELA, CNR1, KIR2DL3, KIR3DL1
28	vasculitis	36.0	PDCD1, VWF, SELE, SELL, SELP, SERPINC1
29	immunodeficiency	35.8	PDCD1, WAS, KIR3DL1, SELL, VIP, BPI
30	thrombosis	35.8	VWF, PCNA, SELE, SELL, SELP, SERPINC1
31	collagenous colitis	35.4	MPO, CD79A, CD40LG, MMP1, APOH, NOD2
32	irritable bowel syndrome	35.2	GCG, VIP, LEP, CHGA, S100A12, MPO
33	primary sclerosing cholangitis	35.1	BPI, CFTR, MPO, MADCAM1, HLA-A, HLA-C
34	arthritis	35.1	SELL, SERPINA1, VIP, MMP3, IL17A, IL1A
35	uveitis	34.9	KIR2DL3, KIR3DL1, KIR2DS2, KIR2DL2, SFTPD, SELE
36	sinusitis	34.7	PIK3CA, PI3, RELA, VWF, SFTPD, PCNA
37	proctitis	34.7	LCN2, MPO, CDH3, FGF2, IL8, TNF
38	polyposis	34.4	KLF4, PDCD1, RELA, PCNA, RB1, SELE
39	peritonitis	34.3	REG1A, REG4, RELA, KIR2DL3, KIR3DL1, VWF
40	eosinophilia	34.2	PDE4A, SFTPD, SELL, SERPINA1, BDKRB2, MPO
41	hypoxia	34.2	PIK3CA, LRP5, PDE4A, RELA, VWF, PCNA
42	rheumatoid arthritis	34.2	IL1R1, IL1RN, MBL2, HLA-DRB1, TNFRSF1A, SRF
43	nasopharyngitis	34.2	PIK3CA, PDCD1, RELA, KIR2DL3, SFRP2, PCNA
44	ankylosing spondylitis	34.0	SERPINA1, BGLAP, CD79A, CD40LG, MMP3, IL17A
45	diarrhea	33.8	PI3, WAS, VWF, GCG, SERPINA1, VIP
46	cholera	33.7	PDE4A, CNR1, GCG, VIP, VDAC1, MUC2
47	familial mediterranean fever	33.7	KIR2DL3, KIR3DL1, KIR2DS2, KIR2DL2, SELL, SELP
48	pyoderma gangrenosum	33.4	CD40LG, CD55, ITGB2, MMP1, MMP10, GUCA1A
49	herpes simplex	33.4	PIK3CA, PCNA, SERPINC1, SERPINE1, VDR, MYC
50	alopecia	33.2	VDR, BIRC5, CLDN1, XDH, T, CD79A

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 azathioprine, balsalazide, balsalazide disodium, hydrocortisone, hydrocortisone acetate, hydrocortisone acetate pwdr [va product], hydrocortisone acetonide, hydrocortisone acetonide pwdr [va product], hydrocortisone buteprate, hydrocortisone butyrate, hydrocortisone cypionate, hydrocortisone probutate, hydrocortisone pwdr [va product], hydrocortisone sodium phosphate, hydrocortisone sodium succinate, hydrocortisone valerate, hydrocortisone,nonsterile pwdr [va product], mesalamine, nicotine, nicotine polacrilex, olsalazine, olsalazine sodium, psyllium, psyllium hydrocolloid, psyllium hydrophilic mucilloid, psyllium mucilloid, psyllium seed coatings,blond, sulfasalazine

Cell-based therapeutics:

MalaCards organs/tissues related to ulcerative colitis:

²²

MGI Mouse Phenotypes related to ulcerative colitis:

²⁵ (show all 29)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	mortality/aging	MP:0010768	19.6	PIK3CA, LRP5, LRP6, KLF4, NCAM1, PDCD1
2	immune system phenotype	MP:0005387	19.1	LRP5, PDE4A, REL, WAS, VWF, SELL
3	cellular phenotype	MP:0005384	18.9	PIK3CA, LRP5, LRP6, KLF4, NCAM1, PDCD1
4	homeostasis/metabolism phenotype	MP:0005376	18.8	PIK3CA, LRP5, LRP6, KLF4, REG1A, REL
5	hematopoietic system phenotype	MP:0005397	18.4	PDCD1, WAS, PCNA, BRAF, MYO9B, BLK
6	normal phenotype	MP:0002873	15.8	LRP5, LRP6, KLF4, RELA, SFRP2, SELE
7	reproductive system phenotype	MP:0005389	15.1	PIK3CA, LRP6, KLF4, REG1A, SFRP2, SERPINF1
8	endocrine/exocrine gland phenotype	MP:0005379	14.4	LRP5, KLF4, REG1A, WAS, SFRP2, SELL
9	growth/size phenotype	MP:0005378	14.3	PIK3CA, LRP6, REL, RELA, CNR1, SFRP2
10	behavior/neurological phenotype	MP:0005386	14.0	PIK3CA, LRP5, LRP6, KLF4, NCAM1, CNR1
11	embryogenesis phenotype	MP:0005380	13.2	PIK3CA, LRP5, LRP6, REL, SFRP2, SERPINC1
12	digestive/alimentary phenotype	MP:0005381	12.8	LRP6, KLF4, REL, WAS, VWF, GCG
13	respiratory system phenotype	MP:0005388	12.7	LRP6, REL, SFTPD, SELL, SELP, LPL
14	nervous system phenotype	MP:0003631	12.6	LRP5, LRP6, PDCD1, PDE4A, REL, RELA
15	cardiovascular system phenotype	MP:0005385	12.5	PIK3CA, LRP5, PDCD1, PDE4A, REL, RELA
16	integument phenotype	MP:0010771	12.4	LRP6, KLF4, REL, RELA, CNR1, RB1
17	liver/biliary system phenotype	MP:0005370	12.3	LRP5, LRP6, REL, SERPINC1, SEL1L, LPL
18	no phenotypic analysis	MP:0003012	12.0	LRP6, CNR1, SFRP2, PCNA, RB1, MYC
19	craniofacial phenotype	MP:0005382	11.9	LRP5, LRP6, KLF4, RARG, PBX2, CITED2
20	renal/urinary system phenotype	MP:0005367	11.9	LRP6, PDCD1, WAS, SELP, BRAF, CLDN7
21	tumorigenesis	MP:0002006	11.5	PIK3CA, KLF4, WAS, RB1, SELL, SERPINE1
22	other phenotype	MP:0005395	11.5	CNR1, SERPINH1, RARG, SCNN1G, LAMC2, JAK2
23	skeleton phenotype	MP:0005390	11.4	LRP6, REL, RELA, CNR1, WAS, RB1
24	limbs/digits/tail phenotype	MP:0005371	10.6	LRP5, LRP6, RELA, SFRP2, RB1, VDR
25	muscle phenotype	MP:0005369	10.4	PIK3CA, PDCD1, RELA, SFRP2, RB1, BSN
26	vision/eye phenotype	MP:0005391	10.2	PIK3CA, LRP5, LRP6, NCAM1, PDCD1, RELA
27	hearing/vestibular/ear phenotype	MP:0005377	10.1	LRP6, RB1, BSN, VDR, MYC, RARG
28	pigmentation phenotype	MP:0001186	10.0	LRP5, RB1, SERPINC1, SERPINF1, BRAF, MYC
29	adipose tissue phenotype	MP:0005375	9.0	PIK3CA, LRP6, CNR1, RB1, SERPINE1, BRAF

Articles related to ulcerative colitis:

(show top 50)    (show all 851)

id	Title	Authors	Year	Affiliating Genes
1	Gene expression of carnitine organic cation transport ers 1 and 2 (OCTN) is downregulated in patients with ulcerative colitis. (21910182)	Yamamoto-Furusho J.K.... Barreto-ZuA+iga R.	2011	SLC22A5, SLC22A4
2	Invasive behavior of ulcerative colitis-associated ca rcinoma is related to reduced expression of CD44 extracellular domain: comparis on with sporadic colon carcinoma. (21473743)	Mikami T.... Okayasu I.	2011	CD44
3	Three ulcerative colitis susceptibility loci are asso ciated with primary sclerosing cholangitis and indicate a role for IL2, REL, an d CARD9. (21425313)	Janse M.... Weersma R.K.	2011	IL2, REL, CARD9
4	Methylation status of genes in non-neoplastic mucosa from patients with ulcerative colitis-associated colorectal cancer. (20160714)	Garrity-Park M.M.... Smyrk T.C.	2010	PTGS2, RUNX3, APBA1
5	Disease-related expression of the IL6/STAT3/SOCS3 sig nalling pathway in ulcerative colitis and ulcerative colitis-related carcinogen esis. (19926618)	Li Y.... van der Woude C.J.	2010	STAT3, SOCS3
6	Expression of co-stimulators in ulcerative colitis a nd its pathologic significance]. (20388394)	Li F.... Shi X.Y.	2010	CD86, ICOS
7	CTLA4 -1661A/G and 3'UTR long repeat polymorphisms ar e associated with ulcerative colitis and influence CTLA4 mRNA and protein expre ssion. (20445568)	Chen Z.... Xia B.	2010	CTLA4
8	MEFV gene mutations and its impact on the clinical co urse in ulcerative colitis patients. (20224922)	YA+ldA+rA+m B.... Alagozlu H.	2010	MEFV
9	Decreased Toll-like receptor-5 (TLR-5) expression in the mucosa of ulcerative colitis patients. (20083854)	Stanislawowski M.... Kmiec Z.	2009	TLR5
10	Polymorphisms of PTPN11 coding SHP-2 as biomarkers for ulcerative colitis susceptibility in the Japanese population. (19160029)	Narumi Y.... Tsukamoto K.	2009	PTPN11, PDCD1
11	Novel genetic risk markers for ulcerative colitis in the IL2/IL21 region are in epistasis with IL23R and suggest a common genetic ba ckground for ulcerative colitis and celiac disease. (19455118)	Glas J.... Brand S.	2009	KIAA1109
12	A case study: interferon-beta-induced remission of ulcerative colitis in a patient with type C chronic hepatitis (18772577)	Miike T.... Shimoda K.	2008	IFNB1
13	Relationship and significance between anti-beta2-glycoprotein I antibodies and platelet activation state in patients with ulcerative colitis. (18205270)	Gao Y.H.... Piao Y.F.	2008	APOH
14	Upregulation of GRAIL is associated with remission of ulcerative colitis. (18467499)	Egawa S.... Hayashi N.	2008	RNF128
15	Expression of Toll-like receptor 2 (TLR2), TLR4, and CD14 in biopsy samples of patients with inflammatory bowel diseases: upregulated expression of TLR2 in terminal ileum of patients with ulcerative colitis. (18040078)	Frolova L.... Tlaskalova-Hogenova H.	2008	TLR2, TLR4, CD14
16	Adacolumn selective leukocyte adsorption apheresis in patients with active ulcerative colitis: clinical efficacy, effects on plasma IL-8, and expression of Toll-like receptor 2 on granulocytes. (17394078)	Aoki H.... Suzuki Y.	2007	IL8
17	Decreased expression of thioredoxin interacting protein mRNA in inflamed colonic mucosa in patients with ulcerative colitis. (17671698)	Takahashi Y.... Asai S.	2007	TXN, TXNIP
18	Spindle proteins Aurora A and BUB1B, but not Mad2, are aberrantly expressed in dysplastic mucosa of patients with longstanding ulcerative colitis. (17322345)	Burum-Auensen E.... Clausen O.P.	2007	MAD2L1
19	Tumor necrosis factor-alpha inhibitor associated ulcerative colitis. (17496730)	Prescott K.... Kazi S.	2007	TNF
20	Killer Ig-like receptor (KIR) genotype and HLA ligand combinations in ulcerative colitis susceptibility. (16929347)	Jones D.C.... Young N.T.	2006	KIR3DL1, HLA-C, KIR2DL3
21	Low detoxification capacity in the ileal pouch mucosa of patients with ulcerative colitis. (16432375)	Berkhout M.... Nagengast F.M.	2006	GSTM1
22	Microheterogeneity of acute phase proteins in patients with ulcerative colitis. (16937531)	GrzymisA8awski M.... Wiktorowicz K.	2006	TF
23	Plasma interleukin-18 reflects severity of ulcerative colitis. (15641156)	Wiercinska-Drapalo A.... Prokopowicz D.	2005	IL18
24	MDR1 gene polymorphism in ulcerative colitis. (14724799)	Glas J.... Folwaczny C.	2004	ABCB1
25	Functional interactions between mucosal IL-1, IL-ra and TGF-beta 1 in ulcerative colitis. (15021969)	Ashwood P.... Powell J.J.	2004	TGFB1, IL1RN
26	Alterations of p53 gene and microsatellite instability in ulcerative colitis and ulcerative colitis-associated colorectal cancer (15067728)	Li J.... Huang Q.	2004	TP53
27	Suppression of pro-inflammatory cytokine release by selective inhibition of inducible nitric oxide synthase in mucosal explants from patients with ulcerative colitis. (12678336)	Kankuri E.... Moilanen E.	2003	IL1B, NOS2
28	Basiliximab (anti-CD25) in combination with steroids may be an effective new treatment for steroid-resistant ulcerative colitis. (12848627)	Creed T.J.... Hearing S.D.	2003	IL2RA
29	Upregulation of CFTR expression but not SLC26A3 and SLC9A3 in ulcerative colitis. (12181169)	Lohi H.... Kere J.	2002	CFTR
30	Risk of osteopenia after proctocolectomy and ileal po uch-anal anastomosis for ulcerative colitis. (11843053)	Kuisma J.... FAorkkilAo M.	2002	CD36, BGLAP
31	A unique basal pattern of p53 expression in ulcerative colitis is associated with mutation in the p53 gene. (11737306)	Noffsinger A.E.... Fenoglio-Preiser C.M.	2001	TP53
32	Expression of glucocorticoid receptor beta in lymphocytes of patients with glucocorticoid-resistant ulcerative colitis. (10784585)	Honda M.... Kohgo Y.	2000	NR3C1
33	Comparable expression of matrix metalloproteinases 1 and 2 in pouchitis and ulcerative colitis. (10940281)	Stallmach A.... Zeitz M.	2000	MMP1
34	Evaluation of the usefulness of testing for p53 mutations in colorectal cancer surveillance for ulcerative colitis. (10022646)	Lashner B.A.... Goldblum J.R.	1999	TP53
35	Prevalence and characterization of perinuclear anti-neutrophil cytoplasmic antibodies (P-ANCA) directed against HMG1 and HMG2 in ulcerative colitis (UC). (9486411)	Sobajima J.... Nakao K.	1998	HMGB2
36	Immunohistochemical detection of MUC2 mucin core protein in ulcerative colitis. (9591701)	Hinoda Y.... Imai K.	1998	MUC2
37	Direct determination of colonic nitric oxide level--a sensitive marker of disease activity in ulcerative colitis. (9517649)	Rachmilewitz D.... Karmeli F.	1998	NOS2
38	A trial of zileuton versus mesalazine or placebo in the maintenance of remission of ulcerative colitis. The European Zileuton Study Group For Ulcerative Colitis. (9041232)	Hawkey C.J.... Lancaster J.F.	1997	ALOX5
39	MUC2 is the prominent colonic mucin expressed in ulcerative colitis. (8707087)	Tytgat K.M.... Dekker J.	1996	MUC2
40	Infrequent DPC4 gene mutation in esophageal cancer, gastric cancer and ulcerative colitis-associated neoplasms. (8957088)	Lei J.... Meltzer S.J.	1996	SMAD4
41	Platelet activating factor: release from colonic muco sa in patients with ulcerative colitis and its effect on colonic secretion. (8675086)	Wardle T.D.... Turnberg L.A.	1996	KNG1
42	High nitric oxide synthase activity in endothelial cells in ulcerative colitis. (7550872)	Iwashita E.... Sawazaki Y.	1995	NOS2
43	Cytokine production in whole blood cell cultures of patients with Crohn's disease and ulcerative colitis. (7869186)	ElsAosser-Beile U.... MAPnting J.S.	1994	TNF, IL1B, IFNG
44	Soluble interleukin-2 receptors, antineutrophil cytoplasmic antibodies, and other autoantibodies in patients with ulcerative colitis. (8504967)	Dalekos G.N.... Moutsopoulos H.M.	1993	IL2RA
45	Autoimmunity to cytoskeletal protein tropomyosin. A clue to the pathogenetic mechanism for ulcerative colitis. (8450225)	Das K.M.... Geng X.	1993	TPM1
46	A study to determine fecal lactoferrin in patients with ulcerative colitis (8492477)	Sudo I.... Saito T.	1993	LTF
47	Relapse-preventing effect and safety of sulfasalazine and olsalazine in patients with ulcerative colitis in remission: a prospective , double-blind, randomized multicenter study. The Ulcerative Colitis Multicente r Study Group. (1348159)	Rijk M.C.... van Tongeren J.H.	1992	HP
48	Oxygen radicals in ulcerative colitis. (1355459)	Babbs C.F.	1992	SOD1
49	Expression of carcinoembryonic antigen in ulcerative colitis, tubular adenomas and hyperplastic polyps: correlations with the degree of dysplasia. (1768036)	Pavelic Z.P.... Peacock J.S.	1991	CEACAM3
50	Differential expression of CD25 (interleukin-2 receptor) on lamina propria T cells and macrophages in the intestinal lesions in Crohn's disease and ulcerative colitis. (2101599)	Choy M.Y.... MacDonald T.T.	1990	IL2RA

Genes related to ulcerative colitis according to GeneCards:

(show top 50)    (show all 571)

id	Symbol	Description	Score	GeneCards Section Context
1	CLDN18	claudin 18	11.1	Publications, Summaries
2	IL2	interleukin 2	11.1	Publications, Summaries
3	MYO9B	myosin IXB	11.1	Publications, Summaries
4	CCL11	chemokine (C-C motif) ligand 11	11.0	Publications
5	TNF	tumor necrosis factor	11.0	Publications
6	LOC442427	putative UPF0607 protein ENSP00000332738-like	11.0	Publications
7	LCA10	lung carcinoma-associated protein 10	11.0
8	IBD2	inflammatory bowel disease 2	11.0	Publications
9	IBD7	inflammatory bowel disease 7	11.0	Publications
10	HLA-DRB9	major histocompatibility complex, class II, DR beta 9 (pseudogene)	11.0	Publications
11	MIR499A	microRNA 499a	11.0	Publications
12	IGKV1-37	immunoglobulin kappa variable 1-37 (non-functional)	11.0
13	DUOXA2	dual oxidase maturation factor 2	11.0	Publications
14	IGHG3	immunoglobulin heavy constant gamma 3 (G3m marker)	11.0	Publications
15	MIR196A2	microRNA 196a-2	11.0	Publications
16	MUC3B	mucin 3B, cell surface associated	11.0	Publications
17	NKX2-3	NK2 homeobox 3	11.0	Publications
18	IRGM	immunity-related GTPase family, M	11.0	Publications
19	DEFA6	defensin, alpha 6, Paneth cell-specific	11.0	Publications
20	DEFB104A	defensin, beta 104A	11.0	Publications
21	GPSM3	G-protein signaling modulator 3	11.0	Publications
22	IL17REL	interleukin 17 receptor E-like	11.0	Publications, Disorders
23	RNF186	ring finger protein 186	11.0	Publications
24	TAC4	tachykinin 4 (hemokinin)	11.0	Publications
25	UQCRQ	ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa	11.0	Publications
26	AQP8	aquaporin 8	11.0	Publications
27	CARD9	caspase recruitment domain family, member 9	11.0	Publications
28	DEFB103B	defensin, beta 103B	11.0	Publications
29	EBI3	Epstein-Barr virus induced 3	11.0	Publications
30	ECM1	extracellular matrix protein 1	11.0	Publications
31	OTUD3	OTU domain containing 3	11.0	Publications
32	PLA2G2E	phospholipase A2, group IIE	11.0	Publications
33	MST1	macrophage stimulating 1 (hepatocyte growth factor-like)	11.0	Publications
34	TNFSF15	tumor necrosis factor (ligand) superfamily, member 15	11.0	Publications
35	BTNL2	butyrophilin-like 2 (MHC class II associated)	11.0	Publications
36	C1orf106	chromosome 1 open reading frame 106	11.0	Publications
37	CCL16	chemokine (C-C motif) ligand 16	11.0	Publications
38	CLDN2	claudin 2	11.0	Publications
39	CLDN8	claudin 8	11.0	Publications
40	DEFA5	defensin, alpha 5, Paneth cell-specific	11.0	Publications
41	EPN3	epsin 3	11.0	Expressions
42	FAM215A	family with sequence similarity 215, member A (non-protein coding)	11.0	Publications
43	HMGB2	high mobility group box 2	11.0	Publications
44	HOXA13	homeobox A13	11.0	Publications
45	IFITM3	interferon induced transmembrane protein 3	11.0	Publications
46	IL1F10	interleukin 1 family, member 10 (theta)	11.0	Publications
47	IL22	interleukin 22	11.0	Publications
48	INSL4	insulin-like 4 (placenta)	11.0	Publications
49	LACC1	laccase (multicopper oxidoreductase) domain containing 1	11.0	Publications
50	MEF2BNB-MEF2B	MEF2BNB-MEF2B readthrough	11.0	Publications

Pathways related to ulcerative colitis according to GeneDecks:

(show top 50)    (show all 193)

id	Pathway	Score	Top Affiliating Genes
1	Immune System38	15.2	NCAM1, PDCD1, REL, KIR2DL3, KIR3DL1, KIR2DS2
2	p38 Signaling36	14.9	RAC1, LIF, BCL2, BAX, MST1R, ATF2
3	Molecular Mechanisms of Cancer36	14.6	LRP5, LRP6, RB1, MYC, LIF, BIRC2
4	PAK Pathway36	14.4	WAS, MYO9B, RAC1, LIF, BCL2, BAX
5	MIF Mediated Glucocorticoid Regulation36	14.2	LIF, BCL2, BAX, CD14, CD80, MIF
6	MIF Regulation of Innate Immune Cells36	14.1	LIF, BCL2, BAX, CD14, CD80, MIF
7	PEDF Induced Signaling36	13.8	RELA, SERPINF1, BRAF, LIF, BCL2, BCL2L1
8	ERK Signaling36	13.8	BRAF, MYC, LAMB1, LAMC2, MST1R, CD80
9	Glucocorticoid Receptor Signaling36	13.6	BCL2, BAX, CDKN1A, CD80, GTF2E2, IL10
10	RAR-Gamma-RXR-Alpha Degradation36	13.4	RARG, LIF, CD80, GTF2E2, IL11, IL15
11	IL-6 Pathway36	13.2	BRAF, BAX, CD80, IL10, IL11, IL12B
12	Chemokine Signaling36	13.0	JAK2, IL8, MAPK3, MAPK14, CCL4, CCL7
13	Influenza A20	12.8	PIK3CA, RELA, VDAC1, ATF2, JAK2, IL12B
14	Chemokine signaling pathway20	12.8	PIK3CA, RELA, WAS, BRAF, RAC1, PARD3
15	Sertoli-Sertoli Cell Junction Dynamics36	12.4	WAS, BRAF, RAC1, CLDN2, CLDN4, CLDN7
16	THC Differentiation Pathway36	12.1	CD86, IL10, IL10RA, IL10RB, IL12B, IL18
17	Toll-like receptor signaling pathway20	12.0	PIK3CA, RELA, RAC1, CD86, CD14, CD80
18	Measles20	12.0	PIK3CA, RELA, BBC3, JAK2, CDK2, CDKN1B
19	Graft-versus-host disease20	12.0	KIR2DL3, KIR3DL1, KIR2DL2, CD86, CD80, IL1A
20	PTEN Pathway36	11.9	BRAF, RAC1, LAMB1, LAMC2, ITGA4, ITGAL
21	ILK Signaling36	11.9	NACA, MYO9B, RAC1, LAMB1, LAMC2, MST1R
22	PPAR Pathway36	11.8	ITGA4, ITGA5, ITGAL, ITGAM, ITGAX, ITGB1
23	Autoimmune thyroid disease20	11.8	CD86, CD40LG, CD80, CD40, GZMB, IL10
24	NF-KappaB Family Pathway36	11.8	REL, RELA, BLK, FGF10, FGF2, FGF7
25	Allograft rejection20	11.8	CD86, CD40LG, CD80, CD40, GZMB, IL10
26	Hematopoietic cell lineage20	11.7	CD24, CD36, CD14, CD59, CD44, CD55
27	Asthma20	11.7	CD40LG, CD40, IL10, IL13, IL4, IL5
28	Jak-STAT signaling pathway20	11.7	PIK3CA, MYC, BCL2L1, LEP, JAK2, IL10
29	JNK Pathway36	11.6	RAC1, BCL2, BAX, MST1R, CD80, FGF2
30	Cytokine production by Th17 cells in CF (Mouse model)41	11.6	REL, RELA, CFTR, JAK2, CD14, FOXP3
31	Immune response MIF-mediated glucocorticoid regulation10	11.6	REL, RELA, MMP1, MIF, IL2, IL6
32	UPA-UPAR Pathway36	11.6	SERPINE1, LAMB1, LAMC2, JAK2, ITGA4, ITGA5
33	IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types37	11.4	GZMB, IL12B, IL17A, IL17F, IL1B, IL21
34	Type I diabetes mellitus20	11.4	CD86, CD80, GZMB, INS, IL12B, IL1A
35	Immune response Role of integrins in NK cells cytotoxicity10	11.4	RAC1, ATF2, ITGA4, ITGAL, ITGAM, ITGB1
36	Cytokine Network36	11.4	IL10, IL12B, IL13, IL15, IL18, IL1A
37	Immune response_Role of integrins in NK cells cytotoxicity41	11.4	RAC1, ATF2, ITGA4, ITGAL, ITGAM, ITGB1
38	Hepatitis C20	11.3	PIK3CA, RELA, BRAF, CLDN2, CLDN4, CLDN7
39	Cell adhesion ECM remodeling10	11.2	SERPINE1, LAMB1, LAMC2, CD44, ITGA5, ITGB1
40	Bacterial infections in CF airways41	11.2	REL, RELA, SFTPD, CFTR, IL1R1, TLR2
41	Cell adhesion_ECM remodeling41	11.2	SERPINE1, LAMB1, LAMC2, CD44, ITGA5, ITGB1
42	Immune response IL-22 signaling pathway10	10.9	MYC, BCL2, BCL2L1, JAK2, CD86, IL10RB
43	Immune response_IL-22 signaling pathway41	10.9	MYC, BCL2, BCL2L1, JAK2, CD86, IL10RB
44	Pancreatic Adenocarcinoma36	10.7	RB1, BRAF, RAC1, BIRC5, BCL2, BCL2L1
45	Colorectal cancer20	10.6	BRAF, RAC1, SMAD2, SMAD3, TGFB1, TGFBR2
46	Cellular Apoptosis Pathway36	10.5	VDAC1, BIRC2, BCL2, BCL2L1, BBC3, BAX
47	Colorectal Cancer Metastasis36	10.4	LRP5, LRP6, BRAF, MYC, BIRC5, BCL2L1
48	Chronic myeloid leukemia20	9.9	PIK3CA, RELA, RB1, BRAF, MYC, BCL2L1
49	Pathways in cancer20	9.7	PIK3CA, RELA, RB1, MYC, RAC1, BIRC2
50	Prostate cancer20	9.1	PIK3CA, RELA, RB1, BRAF, BCL2, CDKN1A

Compounds related to ulcerative colitis according to GeneDecks:

(show top 50)    (show all 473)

id	Compound	Score	Top Affiliating Genes
1	calcium32 9 18 9	26.6	PI3, LRP5, PDE4A, REG1A, REG4, REL
2	atp32	16.4	PIK3CA, NCAM1, PDE4A, WAS, KIR3DL1, RB1
3	oxygen32 18	17.4	PI3, SFTPD, RB1, SERPINF1, SERPINA1, VDAC1
4	superoxide32 18	16.0	PIK3CA, PI3, PDE4A, RB1, SELL, RAC1
5	creatinine32	14.3	NCAM1, VWF, PCNA, GCG, SELE, SELL
6	endotoxin32	14.3	SFTPD, SELL, BPI, LIF, CHKB, S100A9
7	cholesterol32 9 18 9	17.3	PIK3CA, LRP5, VWF, SFTPD, RB1, SELE
8	arginine32	13.8	PIK3CA, PDE4A, CNR1, VWF, GCG, SERPINC1
9	ccl332	13.4	IL10, IL11, IL13, IL15, IL18, IL1A
10	dopamine32 9 18 9	15.6	PIK3CA, NCAM1, PDE4A, GCG, SELE, VIP
11	lysine32	12.4	REL, RELA, KIR3DL1, SERPINA1, VDAC1, LMAN1
12	infliximab32 9 9	14.3	SELE, BGLAP, ITGA4, MMP1, MMP3, FGF2
13	chloroquine32 34 9 9	15.2	SERPINC1, CFTR, CD79A, CDH1, ITGAL, ITGAM
14	salbutamol32 34 9 18 9	16.2	PDE4A, VIP, CHKB, CD79A, ITGB2, IL10
15	lactate32	12.2	PIK3CA, NCAM1, VWF, SFTPD, PCNA, GCG
16	rituximab32 34 9 9	15.0	BIRC2, BIRC5, BCL2, BCL2L1, CD79A, CD59
17	5 aminosalicylic acid32	11.9	NAT1, NAT2, XDH, MPO, IL10, IL11
18	sulfasalazine32 9 9	13.8	SELE, NAT2, MTHFR, MPO, CD79A, CD40LG
19	con a32	11.7	CD79A, ITGB2, MMP14, IL10, IL18, IL2
20	vitamin-e32	11.6	BIRC2, BIRC3, BIRC5, JAK2, CD40, MMP12
21	actinomycin d32	11.6	PIK3CA, PDE4A, RB1, SELE, SERPINE1, VDR
22	glycogen32 18	12.4	PIK3CA, LRP6, GCKR, GCG, VDAC1, MYC
23	agarose32	11.4	VWF, SFTPD, SERPINA1, MYC, LIF, BIRC2
24	homocysteine32 18	12.4	VWF, SELE, SELP, SERPINC1, SERPINE1, NAT1
25	p00332	11.3	RB1, SERPINA1, SERPINE1, LEP, CHGA, MTRR
26	curcumin32	11.2	NAT1, MYC, BIRC2, BIRC3, BIRC5, BCL2
27	norepinephrine32 9 18 9	14.1	PDE4A, CNR1, VWF, GCG, SELE, SELL
28	p00532	11.1	SFTPD, BIRC5, MKI67, CCL5, TNFRSF11B, TNFRSF1A
29	ns 39832 42	12.0	PCNA, BGLAP, CDKN1B, MMP1, FGF2, IL17A
30	melphalan32 9 9	13.0	BIRC5, BCL2L1, CHKB, CD79A, MGMT, GSTP1
31	calcitriol32 42 9 18 9	15.0	RB1, VDR, MYC, LIF, BGLAP, S100A9
32	carbon32	10.8	CNR1, VWF, SFTPD, PCNA, LPL, VDR
33	tgf beta132	10.8	SERPINE1, LIF, CDKN1A, CDK2, CD36, CDKN1B
34	5fluorouracil32	10.8	PIK3CA, PCNA, GCG, RB1, SELE, VDR
35	ascorbic acid32 18	11.7	PCNA, SERPINH1, NAT1, VDR, RAC1, LIF
36	fluvastatin32 34 9 9	13.7	VWF, SELP, SERPINE1, LPL, RAC1, CHKB
37	salicylic acid32	10.6	CNR1, SERPINA1, VDR, MYC, BCL2L1, XDH
38	kininogen32	10.6	VWF, SELP, SERPINC1, SERPINA4, SERPINE1, BDKRB2
39	lovastatin32 42 9 9	13.5	RB1, LPL, RAC1, CHKB, CDKN1A, CDK2
40	agar32	10.4	PIK3CA, RB1, BRAF, VDAC1, RAC1, BIRC5
41	alginate32	10.4	LIF, BGLAP, CD79A, CD36, CD44, MMP14
42	ndga32	10.3	MMP3, FPR1, IL1B, IL2RA, FASN, ANXA5
43	c2ceramide32	10.2	BCL2L1, BAX, CGB5, IL1B, MAPK14, CASP3
44	rottlerin32 42	11.2	RAC1, CD36, CD40LG, ITGAM, IL8, MAPK14
45	octreotide32 42 9 9	12.9	GCG, VIP, CHGA, MPO, MLN, MKI67
46	flavopiridol32 9 9	11.8	RB1, BIRC5, BCL2, BCL2L1, BAX, CDKN1A
47	3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide32	9.6	PCNA, MYC, BCL2, BCL2L1, BAX, CD40
48	geldanamycin32 9 9	11.5	BRAF, BIRC5, BCL2L1, CDKN1A, CDK2, CDK4
49	indole-3-carbinol32	9.4	BIRC5, BCL2, BCL2L1, BAX, CDKN1A, CDK2
50	docetaxel32 34 9 9	12.4	VDR, MYC, BIRC2, BIRC5, BCL2, BCL2L1

Cellular components related to ulcerative colitis according to GeneDecks:

(show all 12)

id	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:005576	17.4	NCAM1, REG1A, REG4, VWF, SFTPD, GCG
2	plasma membrane	GO:005886	16.6	LRP5, LRP6, NCAM1, PDCD1, CNR1, KIR2DL3
3	cytoplasm	GO:005737	16.5	RELA, KIF21B, PCNA, SELP, BSN, NACA
4	extracellular space	GO:005615	16.3	SFRP2, SFTPD, GCG, SELE, SELP, SERPINC1
5	integral to plasma membrane	GO:005887	15.8	CNR1, KIR2DL3, KIR3DL1, SELL, SELP, BPI
6	cytosol	GO:005829	13.3	PIK3CA, PDE4A, REL, RELA, WAS, GCKR
7	cell surface	GO:009986	13.0	LRP6, NCAM1, LPL, CD24, CD36, CD14
8	external side of plasma membrane	GO:009897	12.3	NCAM1, VWF, SELL, SELP, SCNN1B, SCNN1G
9	ER to Golgi transport vesicle membrane	GO:012507	11.2	LMAN1, HLA-A, HLA-B, HLA-C, HLA-DQA1, HLA-DQB1
10	nucleoplasm	GO:005654	11.0	REL, RELA, PCNA, GCKR, RB1, VDR
11	membrane raft	GO:045121	10.9	SELE, JAK2, CD79A, CD24, CD36, CD14
12	secretory granule	GO:030141	10.8	GCG, CHGA, MPO, INS, IL1B, HSPD1

Biological processes related to ulcerative colitis according to GeneDecks:

(show top 50)    (show all 59)

id	Name	GO ID	Score	Top Affiliating Genes
1	immune response	GO:006955	16.9	WAS, KIR2DL3, KIR3DL1, KIR2DS2, BPI, LIF
2	inflammatory response	GO:006954	16.4	RELA, SELE, SELP, RAC1, BDKRB2, S100A12
3	signal transduction	GO:007165	15.7	PDCD1, PDE4A, GCG, VDR, CLIC1, S100A9
4	innate immune response	GO:045087	14.1	RELA, SFTPD, BCL2, BCL2L1, LCN2, S100A12
5	cell-cell signaling	GO:007267	13.6	SFRP2, S100A9, CD86, CD80, ITGB2, MLN
6	apoptotic process	GO:006915	13.2	PDCD1, VDAC1, RAC1, BIRC2, BIRC3, BIRC5
7	chemotaxis	GO:006935	13.2	S100A9, FPR1, FGF2, IL4, MAPK14, CCL4
8	defense response to bacterium	GO:042742	12.9	BPI, S100A12, MICA, IL10, CCL20, IFNB1
9	positive regulation of transcription from RNA polymerase II promoter	GO:045944	12.7	LRP5, LRP6, KLF4, RELA, SFRP2, RB1
10	regulation of immune response	GO:050776	12.7	KIR2DL3, KIR3DL1, KIR2DS2, KIR2DL2, SELL, CD40LG
11	cytokine-mediated signaling pathway	GO:019221	12.5	NCAM1, RELA, JAK2, CD44, IRF5, IL13RA2
12	positive regulation of I-kappaB kinase/NF-kappaB cascade	GO:043123	12.2	REL, RELA, BIRC2, BIRC3, S100A12, CD36
13	positive regulation of inflammatory response	GO:050729	12.1	SERPINE1, JAK2, IL12B, IL15, IL18, IL1RL1
14	virus-host interaction	GO:019048	11.9	RELA, RB1, NACA, VDAC1, CLDN1, BAX
15	interferon-gamma-mediated signaling pathway	GO:060333	11.9	NCAM1, JAK2, CD44, IRF5, IFNG, ICAM1
16	response to lipopolysaccharide	GO:032496	11.9	CNR1, SELE, SELP, SERPINA1, S100A9, JAK2
17	positive regulation of transcription, DNA-dependent	GO:045893	11.9	LRP5, LRP6, KLF4, REL, RELA, RB1
18	response to drug	GO:042493	11.8	PDE4A, SFRP2, LPL, MYC, BGLAP, BDKRB2
19	positive regulation of interferon-gamma production	GO:032729	11.8	CD40LG, IL12B, IL18, IL1B, IL2, IL23A
20	leukocyte migration	GO:050900	11.8	PIK3CA, SELL, SELP, ITGA4, ITGA5, ITGAL
21	positive regulation of interleukin-6 production	GO:032755	11.8	CD36, IL1A, IL1B, IL33, IL6, HSPD1
22	defense response to virus	GO:051607	11.8	RELA, BCL2, CD86, CD40, ITGAX, MICA
23	positive regulation of tumor necrosis factor production	GO:032760	11.8	JAK2, CD36, CD14, IL12B, IL18, IL23A
24	response to glucocorticoid stimulus	GO:051384	11.6	SERPINF1, SERPINE1, BGLAP, IL10, IL1B, IL1RN
25	negative regulation of cell proliferation	GO:008285	11.6	KLF4, SFRP2, VDR, RARG, LIF, BDKRB2
26	positive regulation of interleukin-10 production	GO:032733	11.6	CD40LG, CD83, IL12B, IL21, IL23A, IL4
27	cell surface receptor signaling pathway	GO:007166	11.6	BIRC2, BIRC3, BDKRB2, CD36, CD14, CD59
28	positive regulation of apoptotic process	GO:043065	11.5	LRP6, CNR1, SFRP2, RARG, BAX, JAK2
29	positive regulation of interleukin-12 production	GO:032735	11.5	CD36, CD40LG, CD40, IL12B, IL23A, IL23R
30	response to hypoxia	GO:001666	11.5	SERPINA1, CLDN3, BCL2, SCNN1B, SCNN1G, LEP
31	humoral immune response	GO:006959	11.4	PDCD1, BCL2, CD83, IL6, IL7, CCR6
32	positive regulation of NF-kappaB transcription factor activity	GO:051092	11.3	RELA, CD40, INS, IL1B, IL6, ICAM1
33	response to organic cyclic compound	GO:014070	11.3	SELP, SERPINA1, CDKN1A, CD83, FGF10, MET
34	positive regulation of ERK1 and ERK2 cascade	GO:070374	11.3	GCG, BRAF, CD44, MIF, FGF10, FGF2
35	cellular response to lipopolysaccharide	GO:071222	11.2	SERPINE1, CD36, CD14, GSTP1, IL10, IL12B
36	positive regulation of cell migration	GO:030335	11.2	LAMB1, JAK2, ITGB1, MMP14, INS, FGFR1OP
37	cellular component movement	GO:006928	11.1	RAC1, MST1R, JAK2, ITGAL, FPR1, ARPC2
38	anti-apoptosis	GO:006916	11.0	PIK3CA, RELA, BRAF, BIRC2, BIRC3, BIRC5
39	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO:006919	10.9	MYC, BBC3, BAX, XDH, JAK2, CDKN1B
40	positive regulation of B cell proliferation	GO:030890	10.9	BCL2, CDKN1A, CD40LG, CD40, MIF, IL13
41	lipopolysaccharide-mediated signaling pathway	GO:031663	10.8	IL18, IL1B, MAPK3, MAPK14, CCL2, CCL3
42	positive regulation of cell proliferation	GO:008284	10.6	LRP5, REG1A, SFRP2, VIP, MYC, LIF
43	leukocyte cell-cell adhesion	GO:007159	10.6	SELE, SELP, CD40LG, ITGA4, ITGA5, ITGAL
44	positive regulation of peptidyl-serine phosphorylation	GO:033138	10.5	PIK3CA, SFRP2, GCG, BRAF, LIF, BCL2
45	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	10.4	LIF, JAK2, CD36, CD80, CD44, ITGA5
46	positive regulation of nitric oxide biosynthetic process	GO:045429	10.0	JAK2, INS, IL1B, IFNG, ICAM1, AKT1
47	blood coagulation	GO:007596	10.0	PIK3CA, WAS, VWF, SELL, SELP, SERPINC1
48	response to estrogen stimulus	GO:043627	9.9	SERPINE1, BGLAP, BCL2, CITED2, CD24, FAS
49	negative regulation of apoptotic process	GO:043066	9.5	RELA, GCG, SERPINE1, BRAF, MYC, BIRC2
50	platelet activation	GO:030168	8.8	PIK3CA, VWF, SELP, SERPINA1, SERPINE1, RAC1

Molecular functions related to ulcerative colitis according to GeneDecks:

(show all 11)

id	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:005515	17.4	TCF7L2, PRPF8, PRTN3, PRDX1, CXCR4, SOCS1
2	cytokine activity	GO:005125	13.1	CD40LG, MIF, FGF2, IL10, IL11, IL12B
3	chemokine activity	GO:008009	12.5	CCL17, CCL3, CCL24, CCL5, CXCL1, CXCL10
4	receptor binding	GO:005102	12.3	IL27, HLA-G, TNC, TNFSF15, TNFSF4, CRH
5	receptor activity	GO:004872	12.1	TNFRSF6B, TNFRSF11B, F2RL1, ICAM1, CCR6, PLAUR
6	heparin binding	GO:008201	11.7	CCL7, CCL2, CCL5, PTPRC, CTSG, LTF
7	protein homodimerization activity	GO:042803	11.1	NOD1, NOS2, NFKB1, ABCG2, CRP, SMAD4
8	identical protein binding	GO:042802	10.9	ESR1, AKT1, ALDOB, IGF1R, FAS, APOE
9	growth factor activity	GO:008083	10.6	HBEGF, EGF, F2, IGF2, MDK, TGFA
10	protease binding	GO:002020	10.1	IL1R1, HSPA1B, TP53, TNF, TNFRSF1A, ELANE
11	hormone activity	GO:005179	9.9	CRH, EDN1, STC1, POMC, NMB, ADIPOQ