UC
MCID: ULC004
MIFTS: 71

Ulcerative Colitis (UC) malady

Gastrointestinal category

Summaries for Ulcerative Colitis

Sources:
34MedlinePlus, 3CDC, 21Genetics Home Reference, 64Wikipedia, 47OMIM, 33MalaCards
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MedlinePlus:34 Ulcerative colitis (uc) is a disease that causes inflammation and sores, called ulcers, in the lining of the rectum and colon. it is one of a group of diseases called inflammatory bowel disease. uc can happen at any age, but it usually starts between the ages of 15 and 30. it tends to run in families. the most common symptoms are pain in the abdomen and blood or pus in diarrhea. other symptoms may include anemia severe tiredness weight loss loss of appetite bleeding from the rectum sores on the skin joint pain growth failure in children about half of people with uc have mild symptoms. doctors use blood tests, stool tests, colonoscopy or sigmoidoscopy, and imaging tests to diagnose uc. several types of drugs can help control it. some people have long periods of remission, when they are free of symptoms. in severe cases, doctors must remove the colon. nih: national institute of diabetes and digestive and kidney diseases

MalaCards: Ulcerative Colitis, also known as idiopathic proctocolitis, is related to crohn's disease and colorectal cancer. An important gene associated with Ulcerative Colitis is IL2 (interleukin 2), and among its related pathways are PAK Pathway and Immune response Fc epsilon RI pathway. The drugs azathioprine and hydrocortisone and the compounds peptidoglycan and prednisolone have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and spinal cord, and related mouse phenotypes are immune system and hematopoietic system.

CDC:3 Inflammatory Bowel Diseases (IBD) is a broad term that describes conditions with chronic or recurring immune response and inflammation of the gastrointestinal tract. The two most common inflammatory bowel diseases are ulcerative colitis and Crohn’s disease.

Genetics Home Reference:21 Ulcerative colitis is a chronic disorder that affects the digestive system. This condition is characterized by abnormal inflammation of the inner surface of the rectum and colon, which make up most of the length of the large intestine. The inflammation usually causes open sores (ulcers) to develop in the large intestine. Ulcerative colitis usually appears between ages 15 and 30, although it can develop at any age. The inflammation tends to flare up multiple times throughout life, which causes recurring signs and symptoms.

Wikipedia:64 Ulcerative colitis (Colitis ulcerosa, UC) is a form of inflammatory bowel disease (IBD). Ulcerative... more...

Description from OMIM:47 266600

Aliases & Classifications for Ulcerative Colitis

Sources:
8Disease Ontology, 21Genetics Home Reference, 10DISEASES, 34MedlinePlus, 31LifeMap Discovery™, 61UMLS, 45Novoseek, 57SNOMED-CT, 40NCIt, 35MeSH, 27ICD9CM, 47OMIM, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal


Aliases & Descriptions:

ulcerative colitis 8 21 10 34 31 61
idiopathic proctocolitis 21 61
inflammatory bowel disease, ulcerative colitis type 21
chronic left-sided ulcerative colitis 61
left-sided ulcerative colitis 8
colitis ulcerative 45
colitis gravis 21
uc 21


External Ids:

Disease Ontology8 DOID:8577
NCIt40 C2952
MeSH35 D003093
ICD9CM27 556, 556.9
OMIM47 266600
ICD1025 K51

Related Diseases for Ulcerative Colitis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Ulcerative Colitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 284)
idRelated DiseaseScoreTop Affiliating Genes
1crohn's disease31.4TNFSF15, TNF, NKX2-3, NOD2
2colorectal cancer31.1NOD2, IL2, MUC2
3arthritis30.8TNF, CTSG, NOD2
4celiac disease30.5MYO9B
5bronchiolitis30.5CCL11
6uveitis30.3NOD2, TNF, CCL11
7ankylosing spondylitis30.3TNF
8spondylitis30.3NOD2
9tuberculosis30.3TNF, CTSG, IL2, NOD2
10systemic lupus erythematosus30.0NOD2, IL2, CTSG, TNF
11cholera30.0CCL11, MUC2
12wegener's granulomatosis30.0CTSG
13pouchitis10.9
14sclerosing cholangitis10.9
15pediatric ulcerative colitis10.9
16primary sclerosing cholangitis10.9
17toxic megacolon10.8
18ulcerative proctitis10.8
19proctitis10.8
20pyoderma gangrenosum10.8
21adenoma10.7
22familial adenomatous polyposis10.6
23cytomegalovirus infection10.6
24pericholangitis10.6
25adenocarcinoma10.6
26collagenous colitis10.6
27hepatitis c10.5
28venous thrombosis10.5
29hepatitis a10.5
30irritable bowel syndrome10.5
31duodenitis10.5
32bile duct carcinoma10.5
33vasculitis10.5
34portal vein thrombosis10.4
35autoimmune hemolytic anemia10.4
36autoimmune hepatitis10.4
37bronchiolitis obliterans organizing pneumonia10.4
38bronchiolitis obliterans10.4
39kaposi's sarcoma10.4
40gastroduodenitis10.4
41protein c deficiency10.4
42clostridium difficile10.4
43acute pancreatitis10.3
44polyarteritis nodosa10.3
45gastric ulcer10.3
46protein-losing enteropathy10.3
47hepatitis d10.3
48hepatic vein thrombosis10.3
49amyloidosis10.3
50thrombophlebitis migrans10.2

Graphical network of the top 20 diseases related to Ulcerative Colitis:



Diseases related to ulcerative colitis

Clinical Features for Ulcerative Colitis

Sources:
47OMIM
See all sources

Clinical features from OMIM:

266600

Drugs & Therapeutics for Ulcerative Colitis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Ulcerative Colitis

Drug clinical trials:

Search ClinicalTrials for Ulcerative Colitis

Search NIH Clinical Center for Ulcerative Colitis

Search CenterWatch for Ulcerative Colitis

Inferred drug relations via UMLS61/NDF-RT41:

Show with subtypes

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Ulcerative Colitis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Ulcerative Colitis:
MultiStem
Embryonic/Adult Cultured Cells Related to Ulcerative Colitis:
Bone marrow-derived adherent progenitor cells (MultiStem)

Genetic Tests for Ulcerative Colitis

Anatomical Context for Ulcerative Colitis

Sources:
31LifeMap Discovery™, 33MalaCards
See all sources

MalaCards organs/tissues related to Ulcerative Colitis:

33
Skin, Liver, Spinal cord, Kidney, Lymph node, Lung, Bone marrow, Whole blood, Thymus, Smooth muscle, Small intestine, Colon, Pancreas, Thyroid, Breast, Prostate, Myeloid, Monocytes, Nk cells, T cells, B cells, Endothelial, Bronchial epithelium, Appendix

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Ulcerative Colitis:
id TissueAnatomical CompartmentCell Relevance
1 BoneBone MarrowBone Marrow Stromal Cells Potential therapeutic candidate

Animal Models for Ulcerative Colitis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Ulcerative Colitis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538712.1NOD2, CCL11, CARD9, TNFSF15, TNF, CTSG
2MP:000539711.7CTSG, TNF, TNFSF15, CCL11, NKX2-3, MYO9B
3MP:000538111.4NKX2-3, MUC2, CLDN18, IL2, NOD2, TNF

Publications for Ulcerative Colitis

Sources:
51PubMed
See all sources

Articles related to Ulcerative Colitis:

(show top 50)    (show all 2023)
idTitleAuthorsYear
1
Edwardsiella tarda Superinfection in Relapse of Ulcerative Colitis. (24326755)
2014
2
Novel extended release budesonide formulation for treatment of ulcerative colitis. (24219763)
2014
3
Genome-wide association analysis in primary sclerosing cholangitis and ulcerative colitis identifies risk loci at GPR35 and TCF4. (22821403)
2013
4
The characteristics of ulcerative colitis associated with autoimmune pancreatitis. (23426453)
2013
5
Complementary, integrative, and holistic medicine: integrative approaches to pediatric ulcerative colitis. (24000344)
2013
6
Review article: strategies for the management of chronic unremitting ulcerative colitis. (23718288)
2013
7
Protective effects of hydrogen-rich saline on ulcerative colitis rat model. (23773716)
2013
8
Cancer Risk After Resection of Polypoid Dysplasia in Patients With Longstanding Ulcerative Colitis: A Meta-analysis. (23920032)
2013
9
Procedure time and the determination of polypoid abnormalities with experience: implementation of a chromoendoscopy program for surveillance colonoscopy for ulcerative colitis. (23811635)
2013
10
IBD: Golimumab shows promise in treatment of active ulcerative colitis. (23774769)
2013
11
A Review of the Use of Melatonin in Ulcerative Colitis: Experimental Evidence and New Approaches. (24247651)
2013
12
Letter: mucosal healing in ulcerative colitis--higher relevance than in Crohn's disease? Authors' reply. (23772905)
2013
13
Ulcerative colitis and autoimmune pancreatitis. (23470646)
2013
14
A case of ulcerative colitis complicating anti-tumor necrosis factor treatment for rheumatoid arthritis: successful treatment with leukocytapheresis. (23441783)
2013
15
Celiac disease in a child with ulcerative colitis: a possible genetic association. (23314669)
2013
16
Letter: ciclosporin or infliximab in acute ulcerative colitis - still undecided; authors' reply. (24074312)
2013
17
Possible overuse of 3-stage procedures for active ulcerative colitis. (23700124)
2013
18
Volvulus of an ileal pouch-rectal anastomosis after subtotal colectomy for ulcerative colitis: report of a case. (24048765)
2013
19
An unusual cause of rectal hemorrhage in a patient with well-controlled ulcerative colitis. (23523837)
2013
20
Diagnosis and treatment difficulties in 18-year-old male patient with hereditary hemochromatosis, chronic hepatitis B, Gilbert syndrome and ulcerative colitis. (21633730)
2011
21
Methylation status of genes in non-neoplastic mucosa from patients with ulcerative colitis-associated colorectal cancer. (20160714)
2010
22
Genome-wide association identifies multiple ulcerative colitis susceptibility loci. (20228799)
2010
23
P-glycoprotein functional activity in peripheral blood lymphocytes in ulcerative colitis]. (19770098)
2009
24
Ileal pouch-anal anastomosis and liver transplantation for ulcerative colitis complicated by primary sclerosing cholangitis. (18496886)
2008
25
New aspects concerning ulcerative colitis and colonic carcinoma: analysis of levels of neuropeptides, neurotrophins, and TNFalpha/TNF receptor in plasma and mucosa in parallel with histological evaluation of the intestine. (18452198)
2008
26
Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis. (18318598)
2008
27
Severe chest pain in a pediatric ulcerative colitis patient after 5-aminosalicylic acid therapy. (18666333)
2008
28
Intestinal macrophage/epithelial cell-derived CCL11/eotaxin-1 mediates eosinophil recruitment and function in pediatric ulcerative colitis. (18981162)
2008
29
The proinflammatory CXC-chemokines GRO-alpha/CXCL1 and MIG/CXCL9 are concomitantly expressed in ulcerative colitis and decrease during treatment with topical corticosteroids. (17703315)
2007
30
Serum proinflammatory cytokines and adhesion molecules in ulcerative colitis. (17153445)
2006
31
Alterations in the composition of the supramucosal defense barrier in relation to disease severity of ulcerative colitis. (16924127)
2006
32
Altered angiogenic balance in ulcerative colitis: a key to impaired healing? (17011522)
2006
33
Effects of adacolumn selective leukocytapheresis on plasma cytokines during active disease in patients with active ulcerative colitis. (16733857)
2006
34
Distribution of signal transducer and activator of transcription 6 gene G2964A polymorphism in Chinese patients with ulcerative colitis. (17074026)
2006
35
Ulcerative colitis after statin treatment. (12151572)
2002
36
Activation of nuclear factor-kappaB and effects of anti-inflammatory treatment thereon in intestinal mucosa of patients with ulcerative colitis]. (11953203)
2002
37
The increased expression of an array of C-X-C and C-C chemokines in the colonic mucosa of patients with ulcerative colitis: regulation by corticosteroids. (11808935)
2002
38
Diffuse duodenitis associated with ulcerative colitis. (11023103)
2000
39
Mesalazine inhibits activation of transcription factor NF-kappaB in inflamed mucosa of patients with ulcerative colitis. (11151876)
2000
40
Susceptibility to severe ulcerative colitis is associated with polymorphism in the central MHC gene IKBL. (11113070)
2000
41
Eosinophil activation in ulcerative colitis: studies on mucosal release and localization of eosinophil granule constituents. (9590423)
1998
42
Interleukin-2 production in pediatric inflammatory bowel disease: evidence for dissimilar mononuclear cell function in Crohn's disease and ulcerative colitis. (8271122)
1993
43
Neutrophil mucosal involvement is accompanied by enhanced local production of interleukin-8 in ulcerative colitis. (8406154)
1993
44
Increased production of luminol enhanced chemiluminescence by the inflamed colonic mucosa in patients with ulcerative colitis. (8406152)
1993
45
Low incidence of ulcerative colitis and proctitis in Bangladeshi migrants in Britain. (1426695)
1992
46
Cutaneous polyarteritis nodosa and ulcerative colitis. (1678018)
1991
47
Fatal giant cell myocarditis after colectomy for ulcerative colitis. (3716997)
1986
48
Lactose intolerance in Jewish patients with ulcerative colitis. (5098211)
1971
49
Chronic ulcerative colitis complicated by toxic megacolon. (5922036)
1966
50
"Specific" diseases simulating "nonspecific" ulcerative colitis (lymphopathia venereum, acute vasculitis, scleroderma and secondary amyloidosis. (13470718)
1957

Genetic Variations for Ulcerative Colitis

Expression for genes affiliated with Ulcerative Colitis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Ulcerative Colitis

Search GEO for disease gene expression data for Ulcerative Colitis.

Pathways for genes affiliated with Ulcerative Colitis

Sources:
52QIAGEN, 12EMD Millipore, 30KEGG, 54Reactome, 38NCBI BioSystems Database
See all sources

Compounds for genes affiliated with Ulcerative Colitis

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 60Tocris Bioscience, 24HMDB, 50PharmGKB
See all sources

Compounds related to Ulcerative Colitis according to GeneCards/GeneDecks:

(show all 17)
idCompoundScoreTop Affiliating Genes
1peptidoglycan45 2912.4NOD2, CTSG, TNF, CCL11
2prednisolone45 29 1113.4NOD2, IL2, TNF, CCL11
3indomethacin45 60 29 1114.3CCL11, TNF, CTSG, IL2
4pranlukast45 29 1113.2CCL11, TNF, MUC2
5il 104511.2TNF, IL2, NOD2
6n-formylmethionyl-leucylphenylalanine4511.2CTSG, TNF, CCL11
7histamine45 29 2413.2CCL11, TNF, CTSG, IL2
8leukotriene b445 60 2413.1CTSG, TNF, CCL11
9interferon gamma4511.0TNF, IL2
10piclamilast45 1112.0IL2, TNF
11lenalidomide45 1112.0TNF, IL2
12taurine chloramine4510.9TNF, IL2
13endotoxin4510.9CTSG
14actinomycin d4510.8CCL11, TNF, MUC2, IL2
15toxin-14510.8IL2, TNF
16salmeterol45 50 29 1113.8IL2, CCL11
17gold sodium thiomalate4510.7IL2, TNF

GO Terms for genes affiliated with Ulcerative Colitis

Sources:
16Gene Ontology
See all sources

Biological processes related to Ulcerative Colitis according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of growth of symbiont in hostGO:04413011.2NOD2, CTSG, TNF
2defense response to Gram-positive bacteriumGO:05083011.1NOD2, TNF, CARD9
3positive regulation of interleukin-6 productionGO:03275511.1CARD9, TNF, NOD2
4immune responseGO:00695511.1IL2, CTSG, TNFSF15, CCL11
5positive regulation of JNK cascadeGO:04633011.1NOD2, TNF, CARD9
6positive regulation of humoral immune response mediated by circulating immunoglobulinGO:00292510.9TNF, NOD2
7response to muramyl dipeptideGO:03249510.9NOD2, CARD9
8positive regulation of stress-activated MAPK cascadeGO:03287410.8CARD9, NOD2
9positive regulation of interleukin-17 productionGO:03274010.7IL2, NOD2
10response to exogenous dsRNAGO:04333010.5NOD2, CARD9

Molecular functions related to Ulcerative Colitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1CARD domain bindingGO:05070010.8NOD2, CARD9

Products for genes affiliated with Ulcerative Colitis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Ulcerative Colitis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet