UC
MCID: ULC004
MIFTS: 72

Ulcerative Colitis (UC) malady

Gastrointestinal diseases category

Summaries for Ulcerative Colitis

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21Genetics Home Reference, 33MedlinePlus, 3CDC, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 Ulcerative colitis (uc) is a disease that causes inflammation and sores, called ulcers, in the lining of the rectum and colon. it is one of a group of diseases called inflammatory bowel disease. uc can happen at any age, but it usually starts between the ages of 15 and 30. it tends to run in families. the most common symptoms are pain in the abdomen and blood or pus in diarrhea. other symptoms may include anemia severe tiredness weight loss loss of appetite bleeding from the rectum sores on the skin joint pain growth failure in children about half of people with uc have mild symptoms. doctors use blood tests, stool tests, colonoscopy or sigmoidoscopy, and imaging tests to diagnose uc. several types of drugs can help control it. some people have long periods of remission, when they are free of symptoms. in severe cases, doctors must remove the colon. nih: national institute of diabetes and digestive and kidney diseases

MalaCards: Ulcerative Colitis, also known as idiopathic proctocolitis, is related to crohn's disease and inflammatory bowel disease. An important gene associated with Ulcerative Colitis is IL2 (interleukin 2), and among its related pathways are PAK Pathway and Immune response Fc epsilon RI pathway. The drugs azathioprine and hydrocortisone and the compounds peptidoglycan and prednisolone have been mentioned in the context of this disorder. Affiliated tissues include colon, testes and skin, and related mouse phenotypes are immune system and hematopoietic system.

Genetics Home Reference:21 Ulcerative colitis is a chronic disorder that affects the digestive system. This condition is characterized by abnormal inflammation of the inner surface of the rectum and colon, which make up most of the length of the large intestine. The inflammation usually causes open sores (ulcers) to develop in the large intestine. Ulcerative colitis usually appears between ages 15 and 30, although it can develop at any age. The inflammation tends to flare up multiple times throughout life, which causes recurring signs and symptoms.

CDC:3 Inflammatory Bowel Diseases (IBD) is a broad term that describes conditions with chronic or recurring immune response and inflammation of the gastrointestinal tract. The two most common inflammatory bowel diseases are ulcerative colitis and Crohn’s disease.

Wikipedia:63 Ulcerative colitis (Colitis ulcerosa, UC) is a form of inflammatory bowel disease (IBD). Ulcerative... more...

Description from OMIM:46 266600

Aliases & Classifications for Ulcerative Colitis

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Sources:
8Disease Ontology, 21Genetics Home Reference, 10DISEASES, 44Novoseek, 33MedlinePlus, 30LifeMap Discovery™, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH, 27ICD9CM, 46OMIM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

ulcerative colitis 8 21 10 33 30 60
idiopathic proctocolitis 21 60
inflammatory bowel disease, ulcerative colitis type 21
chronic left-sided ulcerative colitis 60
left-sided ulcerative colitis 8
colitis ulcerative 44
colitis gravis 21
uc 21


External Ids:

Disease Ontology8 DOID:8577
NCIt39 C2952
MeSH34 D003093
ICD9CM27 556, 556.9
OMIM46 266600
ICD1025 K51

Related Diseases for Ulcerative Colitis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Ulcerative Colitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 323)
idRelated DiseaseScoreTop Affiliating Genes
1crohn's disease31.6TNFSF15, TNF, NKX2-3, NOD2
2inflammatory bowel disease31.1CCL11, TNFSF15, TNF, CTSG, MYO9B, MUC2
3colorectal cancer31.1NOD2, IL2, MUC2
4arthritis30.7TNF, CTSG, NOD2
5dermatitis30.7NOD2, CCL11
6rheumatoid arthritis30.6CCL11, TNF, CTSG, IL2, NOD2
7celiac disease30.5MYO9B
8bronchiolitis30.5CCL11
9dermatitis herpetiformis30.5CCL11
10sarcoidosis30.3NOD2, IL2, BTNL2, TNF, CCL11
11uveitis30.3NOD2, TNF, CCL11
12ankylosing spondylitis30.3TNF
13spondylitis30.3NOD2
14wegener's granulomatosis30.3CTSG
15tuberculosis30.3TNF, CTSG, IL2, NOD2
16glomerulonephritis30.2CTSG
17systemic lupus erythematosus30.0NOD2, IL2, CTSG, TNF
18cholera29.9CCL11, MUC2
19peritonitis29.9CTSG, TNF
20sclerosing cholangitis10.9
21cholangitis10.9
22megacolon10.8
23toxic megacolon10.8
24proctitis10.8
25pyoderma10.7
26pyoderma gangrenosum10.7
27colonic disease10.6
28familial adenomatous polyposis10.6
29hepatitis10.6
30cerebritis10.6
31intestinal disease10.6
32pericholangitis10.6
33adenocarcinoma10.6
34colon cancer10.5
35duodenal ulcer10.5
36duodenitis10.5
37hepatitis a10.5
38irritable bowel syndrome10.4
39adenoma10.4
40bile duct carcinoma10.4
41pancreatitis10.4
42pneumonia10.4
43vasculitis10.4
44takayasu's arteritis10.4
45portal vein thrombosis10.4
46autoimmune hemolytic anemia10.4
47autoimmune hepatitis10.4
48gastroduodenitis10.4
49diarrhea10.4
50hemolytic anemia10.4

Graphical network of the top 20 diseases related to Ulcerative Colitis:



Diseases related to ulcerative colitis

Clinical Features for Ulcerative Colitis

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Sources:
46OMIM
See all sources

Clinical features from OMIM:

266600

Drugs & Therapeutics for Ulcerative Colitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Ulcerative Colitis

Drug clinical trials:

Search ClinicalTrials for Ulcerative Colitis

Search NIH Clinical Center for Ulcerative Colitis

Search CenterWatch for Ulcerative Colitis

Inferred drug relations via UMLS60/NDF-RT40:

Show with subtypes

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Ulcerative Colitis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Ulcerative Colitis:
MultiStem
Embryonic/Adult Cultured Cells Related to Ulcerative Colitis:
Bone marrow-derived adherent progenitor cells (MultiStem)

Genetic Tests for Ulcerative Colitis

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Anatomical Context for Ulcerative Colitis

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30LifeMap Discovery™, 32MalaCards
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MalaCards organs/tissues related to Ulcerative Colitis:

32
Colon, Testes, Skin, T cells, Kidney, Bone, Liver, Monocytes, Bone marrow, Endothelial, Thyroid, Appendix, B cells, Myeloid, Whole blood, Smooth muscle, Prostate, Pancreas, Spinal cord, Breast, Lymph node, Eye, Lung, Thymus

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Ulcerative Colitis:
id TissueAnatomical CompartmentCell Relevance
1 BoneBone MarrowBone Marrow Stromal Cells Potential therapeutic candidate

Animal Models for Ulcerative Colitis or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Ulcerative Colitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538712.1NOD2, CCL11, CARD9, TNFSF15, TNF, CTSG
2MP:000539711.7CTSG, TNF, TNFSF15, CCL11, NKX2-3, MYO9B
3MP:000538111.4NKX2-3, MUC2, CLDN18, IL2, NOD2, TNF

Publications for Ulcerative Colitis

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Sources:
50PubMed
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Articles related to Ulcerative Colitis:

(show top 50)    (show all 2034)
idTitleAuthorsYear
1
Sternocostal involvement in chronic recurrent multifocal osteomyelitis associated with ulcerative colitis. (22961119)
2013
2
Malignant melanoma of the ileo-anal pouch anastomosis after restorative proctocolectomy for ulcerative colitis: report of a case. (24188588)
2013
3
VEGF-A isoform modulation in an preclinical TNBS model of ulcerative colitis: protective effects of a VEGF164b therapy. (24020796)
2013
4
IRF5, but not TLR4, DEFEB1, or VDR, is associated with the risk of ulcerative colitis in a Han Chinese population. (23971939)
2013
5
Curbing our enthusiasm for fecal transplantation in ulcerative colitis. (24091506)
2013
6
An unusual complication in ulcerative colitis during treatment with azathioprine and infliximab: Isospora belli as 'Casus belli'. (23709557)
2013
7
Chest pain in a 12-year-old girl with ulcerative colitis after therapy with mesalazine. (23761603)
2013
8
Cytomegalovirus infection associated with onset of ulcerative colitis. (23375026)
2013
9
Adenoma-like and non-adenoma-like dysplasia-associated lesion or mass in ulcerative colitis. (23374421)
2013
10
Flare up of ulcerative colitis during pregnancy treated by adsorptive granulocyte and monocyte apheresis: therapeutic outcomes in three pregnant patients. (23404436)
2013
11
IBD: Golimumab in ulcerative colitis: a 'mAcnage A trois' of drugs. (23897288)
2013
12
Randomised clinical trial: a herbal preparation of myrrh, chamomile and coffee charcoal compared with mesalazine in maintaining remission in ulcerative colitis--a double-blind, double-dummy study. (23826890)
2013
13
Restorative proctocolectomy for ulcerative colitis: development and validation of a new scoring system for pouch dysfunction and quality of life. (24103094)
2013
14
Review article: the role of anti-TNF in the management of ulcerative colitis -- past, present and future. (23489068)
2013
15
Establishment of a novel mouse model of ulcerative colitis with concomitant cytomegalovirus infection: in vivo identification of cytomegalovirus persistent infected cells. (23839229)
2013
16
Total abdominal colectomy for severe ulcerative colitis: does the laparoscopic approach really have benefit? (24196546)
2013
17
Ulcerative colitis in Henoch-SchAPnlein purpura: which came first, the chicken or the egg? (23692135)
2013
18
Cost-Effectiveness of Infliximab for the Treatment of Acute Exacerbations of Ulcerative Colitis in the Netherlands. (24392304)
2013
19
STAT1, STAT6 and adenosine 3',5'-cyclic monophosphate (cAMP) signaling drive SOCS3 expression in inactive ulcerative colitis. (23154639)
2012
20
Colorectal small cell carcinoma in ulcerative colitis with identical rare p53 gene mutation to associated adenocarcinoma and dysplasia. (22261536)
2012
21
Association of the RAVER2 gene with increased susceptibility for ulcerative colitis. (22561236)
2012
22
A case of ulcerative colitis complicated with bronchiolitis obliterans organizing pneumonia (BOOP) and air leak syndrome. (23161307)
2012
23
The effects of liver transplantation on the clinical course of colitis in ulcerative colitis patients with primary sclerosing cholangitis. (22428731)
2012
24
Role of miR-150-targeting c-Myb in colonic epithelial disruption during dextran sulphate sodium-induced murine experimental colitis and human ulcerative colitis. (21590770)
2011
25
Pyoderma vegetans associated with ulcerative colitis: a case with good response to steroids. (21503165)
2011
26
HLA-Cw*1202-B*5201-DRB1*1502 haplotype increases risk for ulcerative colitis but reduces risk for Crohn's disease. (21699788)
2011
27
Interleukin-33 expression is specifically enhanced in inflamed mucosa of ulcerative colitis. (20405148)
2010
28
Elevated IL-13Ralpha2 in intestinal epithelial cells from ulcerative colitis or colorectal cancer initiates MAPK pathway. (20014020)
2010
29
HLA-B is the best candidate of susceptibility genes in HLA for Japanese ulcerative colitis. (19493234)
2009
30
Transforming growth factor-beta1 and its receptors in patients with ulcerative colitis. (19285572)
2009
31
Effect of Candida colonization on human ulcerative colitis and the healing of inflammatory changes of the colon in the experimental model of colitis ulcerosa. (19439813)
2009
32
Accumulation, activation, and survival of neutrophils in ulcerative colitis: regulation by locally produced factors in the colon and impact of steroid treatment. (18594843)
2008
33
Interleukin-10 promoter polymorphisms influence susceptibility to ulcerative colitis in a gender-specific manner. (18569989)
2008
34
Persistent vaginal discharge after proctocolectomy for ulcerative colitis. (17824988)
2007
35
Diffuse gastroduodenitis and pouchitis associated with ulcerative colitis. (17007066)
2006
36
MICB microsatellite polymorphism is associated with ulcerative colitis in Chinese population. (16679067)
2006
37
Chronic pouchitis after ileal pouch-anal anastomosis for ulcerative colitis: effect on quality of life. (16627228)
2006
38
Impact of selective leukocytapheresis on mucosal inflammation and ulcerative colitis: cytokine profiles and endoscopic findings. (16917227)
2006
39
Analysis of cytotoxic T lymphocyte associated antigen 4 gene polymorphisms in patients with ulcerative colitis. (16509873)
2006
40
Nonclassical CD1d-restricted NK T cells that produce IL-13 characterize an atypical Th2 response in ulcerative colitis. (15146247)
2004
41
Factors associated with disease activity of pouchitis after surgery for ulcerative colitis. (15223678)
2004
42
Primary AL-amyloidosis, ulcerative colitis and collagenous colitis in a 57-year-old woman: a case study. (15743012)
2004
43
Abnormal p53 immunohistochemistry is associated with an increased colorectal cancer-related mortality in patients with ulcerative colitis. (12818291)
2003
44
N-acetyltransferase 1 and 2 genotypes do not predict response or toxicity to treatment with mesalamine and sulfasalazine in patients with ulcerative colitis. (12135032)
2002
45
A polymorphism in the IL11 gene is associated with ulcerative colitis. (12486609)
2002
46
A close relationship of triplet repeat polymorphism in MHC class I chain-related gene A (MICA) to the disease susceptibility and behavior in ulcerative colitis. (11169253)
2001
47
Transdermal nicotine decreases mucosal IL-8 expression but has no effect on mucin gene expression in ulcerative colitis. (10453373)
1999
48
Antioxidants inhibit the in vitro production of inflammatory cytokines in Crohn's disease and ulcerative colitis. (9541129)
1998
49
Immunohistochemical detection of MUC2 mucin core protein in ulcerative colitis. (9591701)
1998
50
Increased numbers of interleukin-15-expressing cells in active ulcerative colitis. (8792700)
1996

Genetic Variations for Ulcerative Colitis

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Expression for genes affiliated with Ulcerative Colitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Ulcerative Colitis

Search GEO for disease gene expression data for Ulcerative Colitis.

Pathways for genes affiliated with Ulcerative Colitis

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Sources:
51QIAGEN, 12EMD Millipore, 29KEGG, 53Reactome, 37NCBI BioSystems Database
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Compounds for genes affiliated with Ulcerative Colitis

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44Novoseek, 28IUPHAR, 11DrugBank, 59Tocris Bioscience, 24HMDB, 49PharmGKB
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Compounds related to Ulcerative Colitis according to GeneCards/GeneDecks:

(show all 17)
idCompoundScoreTop Affiliating Genes
1peptidoglycan44 2812.4NOD2, CTSG, TNF, CCL11
2prednisolone44 28 1113.4NOD2, IL2, TNF, CCL11
3indomethacin44 59 28 1114.3CCL11, TNF, CTSG, IL2
4pranlukast44 28 1113.2CCL11, TNF, MUC2
5il 104411.2TNF, IL2, NOD2
6n-formylmethionyl-leucylphenylalanine4411.2CTSG, TNF, CCL11
7histamine44 28 2413.2CCL11, TNF, CTSG, IL2
8leukotriene b444 59 2413.1CTSG, TNF, CCL11
9interferon gamma4411.0TNF, IL2
10piclamilast44 1112.0IL2, TNF
11lenalidomide44 1112.0TNF, IL2
12taurine chloramine4410.9TNF, IL2
13endotoxin4410.9CTSG
14actinomycin d4410.8CCL11, TNF, MUC2, IL2
15toxin-14410.8IL2, TNF
16salmeterol44 49 28 1113.8IL2, CCL11
17gold sodium thiomalate4410.7IL2, TNF

GO Terms for genes affiliated with Ulcerative Colitis

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16Gene Ontology
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Biological processes related to Ulcerative Colitis according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of growth of symbiont in hostGO:04413011.2NOD2, CTSG, TNF
2defense response to Gram-positive bacteriumGO:05083011.1NOD2, TNF, CARD9
3positive regulation of interleukin-6 productionGO:03275511.1CARD9, TNF, NOD2
4immune responseGO:00695511.1IL2, CTSG, TNFSF15, CCL11
5positive regulation of JNK cascadeGO:04633011.1NOD2, TNF, CARD9
6positive regulation of humoral immune response mediated by circulating immunoglobulinGO:00292510.9TNF, NOD2
7response to muramyl dipeptideGO:03249510.9NOD2, CARD9
8positive regulation of stress-activated MAPK cascadeGO:03287410.8CARD9, NOD2
9positive regulation of interleukin-17 productionGO:03274010.7IL2, NOD2
10response to exogenous dsRNAGO:04333010.5NOD2, CARD9

Molecular functions related to Ulcerative Colitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1CARD domain bindingGO:05070010.8NOD2, CARD9

Products for genes affiliated with Ulcerative Colitis

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  • Antibodies
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Sources for Ulcerative Colitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet