Aliases & Classifications for Ulcerative Colitis

MalaCards integrated aliases for Ulcerative Colitis:

Name: Ulcerative Colitis 37 12 72 24 36 40 3 14 69
Inflammatory Bowel Disease, Ulcerative Colitis Type 24
Chronic Left-Sided Ulcerative Colitis 69
Left-Sided Ulcerative Colitis 12
Left Sided Ulcerative Colitis 69
Idiopathic Proctocolitis 24
Colitis, Ulcerative 41
Colitis Ulcerative 51
Colitis Gravis 24
Uc 24

Classifications:



Summaries for Ulcerative Colitis

MedlinePlus : 40 Ulcerative colitis (UC) is a disease that causes inflammation and sores, called ulcers, in the lining of the rectum and colon. It is one of a group of diseases called inflammatory bowel disease. UC can happen at any age, but it usually starts between the ages of 15 and 30. It tends to run in families. The most common symptoms are pain in the abdomen and blood or pus in diarrhea. Other symptoms may include Anemia Severe tiredness Weight loss Loss of appetite Bleeding from the rectum Sores on the skin Joint pain Growth failure in children About half of people with UC have mild symptoms. Doctors use blood tests, stool tests, colonoscopy or sigmoidoscopy, and imaging tests to diagnose UC. Several types of drugs can help control it. Some people have long periods of remission, when they are free of symptoms. In severe cases, doctors must remove the colon. NIH: National Institute of Diabetes and Digestive and Kidney Diseases

MalaCards based summary : Ulcerative Colitis, also known as inflammatory bowel disease, ulcerative colitis type, is related to pyoderma gangrenosum and pouchitis, and has symptoms including gastrointestinal gas, nausea and vomiting and icterus. An important gene associated with Ulcerative Colitis is NOD2 (Nucleotide Binding Oligomerization Domain Containing 2), and among its related pathways/superpathways are Cytokine-cytokine receptor interaction and Jak-STAT signaling pathway. The drugs Azathioprine and Hydrocortisone have been mentioned in the context of this disorder. Affiliated tissues include Bone, colon and colon, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Disease Ontology : 12 A colitis that is predominantly confined to the mucosa located in colon and includes characteristic ulcers, or open sores.

Genetics Home Reference : 24 Ulcerative colitis is a chronic disorder that affects the digestive system. This condition is characterized by abnormal inflammation of the inner surface of the rectum and colon, which make up most of the length of the large intestine. The inflammation usually causes open sores (ulcers) to develop in the large intestine. Ulcerative colitis usually appears between ages 15 and 30, although it can develop at any age. The inflammation tends to flare up multiple times throughout life, which causes recurring signs and symptoms.

CDC : 3 Inflammatory Bowel Disease (IBD) is a broad term that describes conditions characterized by chronic inflammation of the gastrointestinal tract. The two most common inflammatory bowel diseases are ulcerative colitis and Crohn’s disease. Inflammation affects the entire digestive tract in Crohn’s disease and only the large intestine (also called the colon) in ulcerative colitis. Both illnesses involved an abnormal response to the body’s immune system.

Wikipedia : 72 Ulcerative colitis (UC) is a long-term condition that results in inflammation and ulcers of the colon... more...

Related Diseases for Ulcerative Colitis

Diseases related to Ulcerative Colitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 581)
# Related Disease Score Top Affiliating Genes
1 pyoderma gangrenosum 33.0 CXCL8 NOD2 TNF
2 pouchitis 33.0 CXCL8 IL10 NOD2
3 inflammatory bowel disease 25, autosomal recessive 32.6 IL10 IL10RA
4 pyoderma 31.6 CXCL8 NOD2 TNF
5 colorectal cancer 31.5 ABCB1 CTNNB1 CXCL8 IL10 IL1B IL2
6 cytomegalovirus infection 31.1 CXCL8 IL10 TNF
7 proctitis 31.1 CRP MPO TNF
8 ileitis 31.0 MPO NOD2 TNF
9 crohn's colitis 30.9 CXCL8 IL1B IL2 NOD2 TNF
10 celiac disease 1 30.8 IL10 IL2 MYO9B TNF
11 adenoma 30.7 CTNNB1 MLH1 MSH2 MUC2
12 inflammatory bowel disease 30.7 ABCB1 ATG16L1 CRP CXCL8 IL10 IL10RA
13 bronchiolitis obliterans 30.7 CXCL8 IL10 TNF
14 arthritis 30.6 CXCL8 IL10 IL1B NOD2 TNF
15 bronchiolitis 30.6 CXCL8 IL10 TNF
16 spondyloarthropathy 30.6 IL10 IL2 TNF
17 uveitis 30.5 IL10 NOD2 TNF
18 ileocolitis 30.4 MYO9B NOD2 TNF
19 colonic benign neoplasm 30.4 CTNNB1 MLH1 MSH2
20 crohn's disease 30.4 ABCB1 ATG16L1 CRP IL10 IL10RA IL1B
21 autoimmune inner ear disease 30.4 MPO TNF
22 osteomyelitis 30.3 CXCL8 IL10 IL1B TNF
23 spondyloarthropathy 1 30.3 CRP NOD2 TNF
24 spondylitis 30.3 CRP IL23R NOD2 TNF
25 hematopoietic stem cell transplantation 30.3 IL10 IL2 TNF
26 vaginitis 30.3 ABCB1 CXCL8 IL1B
27 psoriasis 30.2 CXCL8 IL10 IL1B IL2 IL23R TNF
28 prostatitis 30.2 CXCL8 IL10 IL1B TNF
29 helicobacter pylori infection 30.2 CXCL8 IL10 IL1B TNF
30 transverse myelitis 30.2 CXCL8 IL10 TNF
31 leprosy 3 30.2 IL10 IL2 NOD2 TNF
32 alopecia areata 30.2 IL1B IL2 TNF
33 tonsillitis 30.1 CXCL8 IL1B IL2 TNF
34 lynch syndrome 30.1 CTNNB1 MLH1 MSH2 MUC2
35 familial mediterranean fever 30.1 CRP IL1B NOD2 TNF
36 bronchitis 30.0 CXCL8 MPO TNF
37 acute pancreatitis 30.0 CRP CXCL8 IL10 MPO
38 rheumatoid arthritis 30.0 CRP CXCL8 IL10 IL1B IL2 TNF
39 bronchial disease 30.0 CXCL8 IL10 IL1B TNF
40 inner ear disease 30.0 MPO TNF UCN
41 pneumonia 29.9 CRP CXCL8 IL10 IL1B MPO TNF
42 pericarditis 29.9 CRP IL1B TNF
43 reactive arthritis 29.9 CRP IL10 TNF
44 chronic fatigue syndrome 29.9 CXCL8 IL10 IL1B IL2 TNF
45 lymphadenitis 29.9 CXCL8 IL10 IL1B NOD2 TNF
46 colitis 29.9 ABCB1 ATG16L1 CTNNB1 CXCL8 IL10 IL10RA
47 meningitis 29.8 CRP CXCL8 IL10 IL1B TNF
48 autoimmune disease 29.8 IL10 IL1B IL2 TNF
49 brucellosis 29.8 CRP CXCL8 IL10 IL2 TNF
50 pleurisy 29.8 CRP CXCL8 IL2 MPO TNF

Comorbidity relations with Ulcerative Colitis via Phenotypic Disease Network (PDN): (show all 11)


Active Peptic Ulcer Disease Acute Cystitis
Crohn's Disease Deficiency Anemia
Esophagitis Hypothyroidism
Inflammatory Bowel Disease 1 Intestinal Obstruction
Iron Deficiency Anemia Paralytic Ileus
Protein-Energy Malnutrition

Graphical network of the top 20 diseases related to Ulcerative Colitis:



Diseases related to Ulcerative Colitis

Symptoms & Phenotypes for Ulcerative Colitis

UMLS symptoms related to Ulcerative Colitis:


gastrointestinal gas, nausea and vomiting, icterus, heartburn, dyspepsia, diarrhea, constipation, abdominal pain

GenomeRNAi Phenotypes related to Ulcerative Colitis according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.88 MPO MYO9B NOD2 CXCL8 TNF IL10
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.88 MPO MYO9B NOD2 CXCL8 TNF IL10

MGI Mouse Phenotypes related to Ulcerative Colitis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 10.15 IL23R IL10 ABCB1 IL10RA ATG16L1 IL2
2 cellular MP:0005384 10.14 IL2 CTNNB1 IL10 IL10RA ATG16L1 MUC2
3 cardiovascular system MP:0005385 10.13 CTNNB1 IL10 ABCB1 ATG16L1 IL1B CRP
4 hematopoietic system MP:0005397 10.1 IL23R IL10 ABCB1 IL10RA ATG16L1 IL1B
5 homeostasis/metabolism MP:0005376 10.06 IL23R IL10 ABCB1 IL10RA ATG16L1 IL1B
6 endocrine/exocrine gland MP:0005379 9.97 CTNNB1 IL23R IL10 ABCB1 ATG16L1 IL2
7 immune system MP:0005387 9.83 IL23R IL10 ABCB1 IL10RA ATG16L1 IL1B
8 neoplasm MP:0002006 9.28 CTNNB1 IL23R IL10 IL1B IL2 MLH1

Drugs & Therapeutics for Ulcerative Colitis

Drugs for Ulcerative Colitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 310)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azathioprine Approved Phase 4,Phase 3,Phase 2 446-86-6 2265
2
Hydrocortisone Approved, Vet_approved Phase 4,Phase 1,Phase 2 50-23-7 657311 5754
3
Infliximab Approved Phase 4,Phase 3,Phase 2,Phase 1 170277-31-3
4
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 83-43-2 6741
5
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-24-8 5755
6
Iron Approved Phase 4,Phase 3,Phase 2 7439-89-6 23925
7
Adalimumab Approved Phase 4,Phase 3,Phase 2,Phase 1 331731-18-1 16219006
8
Aminosalicylic Acid Approved Phase 4,Phase 3,Phase 2,Phase 1 65-49-6 4649
9
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
10
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 2 22916-47-8 4189
11
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 1 1994-09-7, 94-09-7 2337
12
Tacrolimus Approved, Investigational Phase 4,Phase 3,Phase 2 104987-11-3 445643 439492
13
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2 53-03-2 5865
14
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613 2171
15
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 2 564-25-0 54671203
16
Metronidazole Approved Phase 4,Phase 3,Phase 2,Phase 1 443-48-1 4173
17
Nicotine Approved Phase 4 54-11-5 89594 942
18 Vedolizumab Approved Phase 4,Phase 3,Phase 2,Early Phase 1 943609-66-3
19
Guaifenesin Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 1 93-14-1 3516
20
Omeprazole Approved, Investigational, Vet_approved Phase 4,Phase 1,Phase 2 73590-58-6 4594
21
Methotrexate Approved Phase 4,Phase 2 1959-05-2, 59-05-2 126941
22
Vancomycin Approved Phase 4,Phase 1 1404-90-6 14969 441141
23
Angiotensin II Approved, Investigational Phase 4 68521-88-0, 4474-91-3, 11128-99-7 172198 65143
24
Dextromethorphan Approved Phase 4 125-71-3 5362449 5360696
25
Losartan Approved Phase 4 114798-26-4 3961
26
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
27
Copper Approved, Investigational Phase 4 7440-50-8 27099
28
Zinc Approved, Investigational Phase 4 7440-66-6 32051 23994
29
Thioguanine Approved Phase 4 154-42-7 2723601
30
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
31
gamma-Aminobutyric acid Approved, Investigational Phase 4 56-12-2 119
32 tannic acid Approved, Nutraceutical Phase 4,Phase 3,Phase 1
33
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 1 59-30-3 6037
34
leucovorin Approved, Nutraceutical Phase 4,Phase 2 58-05-9 143 6006
35
Vitamin C Approved, Nutraceutical Phase 4 50-81-7 54670067 5785
36
Caffeine Approved, Nutraceutical Phase 4 58-08-2 2519
37 Tocopherol Approved, Investigational, Nutraceutical Phase 4,Phase 2
38
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4,Phase 2 59-02-9 14985
39
Butyric Acid Experimental, Investigational Phase 4,Phase 2 107-92-6 264
40 Antibodies Phase 4,Phase 3,Phase 2,Phase 1
41 Antibodies, Monoclonal Phase 4,Phase 3,Phase 2,Phase 1
42 Immunoglobulins Phase 4,Phase 3,Phase 2,Phase 1
43 6-Mercaptopurine Phase 4,Phase 3,Phase 2
44 Antiemetics Phase 4,Phase 3,Phase 2,Phase 1
45 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1
46 Antimetabolites Phase 4,Phase 3,Phase 2
47 Antimetabolites, Antineoplastic Phase 4,Phase 3,Phase 2
48 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2
49 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1
50 Autonomic Agents Phase 4,Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 867)

# Name Status NCT ID Phase Drugs
1 Physiological Intermolecular Modification Spectroscopy (PIMS) in Ulcerative Colitis With Golimumab Unknown status NCT02186886 Phase 4 Golimumab
2 Role of Healthy Bacteria in Ulcerative Colitis Unknown status NCT01479660 Phase 4 Probiotic
3 Golimumab in Steroid-dependent Ulcerative Colitis: Induction and Maintenance of Clinical and Endoscopic Remission Unknown status NCT02412085 Phase 4 Golimumab
4 A Randomized, Multicenter Open Label Study Comparing Early Administration of Azathioprine Plus IFX to Steroids Plus Azathioprine for Acute Severe Colitis Unknown status NCT02425852 Phase 4 Azathioprine;Infliximab;Prednisolone;Hydrocortisone
5 The Effect of Probiotics on the Rate of Recovery of Inflammatory Bowel Disease Exacerbation, Endothelial Function, and Markers of Inflammation Unknown status NCT01078935 Phase 4
6 Confocal Endomicroscopy During Endoscopy Unknown status NCT00988273 Phase 4
7 "Efficacy and Safety of Infliximab-biosimilar (Inflectra) Compared to Infliximab-innovator (Remicade) in Patients With Inflammatory Bowel Disease in Remission: the SIMILAR Trial" Unknown status NCT02452151 Phase 4 Infliximab-Biosimilar;Infliximab-Innovator
8 The Effect of Probiotics on Exacerbation of Inflammatory Bowel Disease Exacerbation (Crohn's Disease) Unknown status NCT01765998 Phase 4 Probiotic;Placebo
9 A Prospective, Placebo Controlled, Double-Blind, Cross-over Study on the Effects of a Probiotic Preparation (VSL#3) on Metabolic Profile, Intestinal Permeability, Microbiota, Cytokines and Chemokines Expression and Other Inflammatory Markers in Pediatric Unknown status NCT01632462 Phase 4 VSL#3
10 Manipulation of Visceral Sensitivity and Immune System in IBS Unknown status NCT00418340 Phase 4 probiotic (bacterial/dietary supplement)
11 Precision Dosing of Infliximab Versus Conventional Dosing of Infliximab Unknown status NCT02453776 Phase 4 PRECISION dosing Infliximab
12 Pain Relief In Irritable Bowel Syndrome Unknown status NCT02573844 Phase 4 Proklama
13 Treatment of Ulcerative Colitis With Ciprofloxacin and E. Coli Nissle Completed NCT01772615 Phase 4 Ciprofloxacin
14 Evaluation of Histologic and Endoscopic Remission Induced by Infliximab in Moderate to Severe Ulcerative Colitis Completed NCT01408810 Phase 4 Infliximab
15 A Long Term Safety Study of Infliximab (Remicade) in in Ulcerative Colitis Patients Completed NCT00207688 Phase 4 Infliximab 5 mg/kg;Infliximab 10 mg/kg;Placebo
16 Golimumab Utilization and Impact on Ulcerative Colitis (MK-8259-032) Completed NCT02092285 Phase 4 Golimumab
17 Strategies in Maintenance for Patients Receiving Long-term Therapy (S.I.M.P.L.E.) With MMX (Multi-Matrix System) Mesalamine for Ulcerative Colitis (UC) Completed NCT00446849 Phase 4 MMX Mesalamine
18 Preference for a Prefilled Syringe or Smartject™ Device for Delivering Golimumab in Participants Suffering From Moderate-to-severe Ulcerative Colitis (MK-8259-027) Completed NCT02155335 Phase 4 Prefilled Syringe delivery of Golimumab;Smartject Device delivery of Golimumab
19 Once Versus Twice Daily Mesalamine to Induce Remission in Pediatric Ulcerative Colitis Completed NCT01201122 Phase 4 Mesalamine
20 Study Comparing Cyclosporine With Infliximab in Steroid-refractory Severe Attacks of Ulcerative Colitis Completed NCT00542152 Phase 4 CYCLOSPORINE VS INFLIXIMAB
21 European Safety Registry in Ulcerative Colitis (Study P04808AM3) Completed NCT00705484 Phase 4 Standard Therapy
22 Asacol Dosing Study for Active Ulcerative Colitis Completed NCT00194818 Phase 4 Asacol (mesalamine)
23 Adacolumn in Refractory UC Patients Trial Completed NCT01481142 Phase 4
24 Dose Escalation and Remission (DEAR) Completed NCT00652145 Phase 4 mesalamine
25 Ability to Maintain or Achieve Clinical and Endoscopic Remission With MMX Mesalamine Once Daily in Adults With Ulcerative Colitis Completed NCT01124149 Phase 4 MMX mesalamine/ mesalazine
26 Study for the Treatment of Ulcerative Colitis With Adacolumn (Companion to US Study 512-04-205) Completed NCT00219414 Phase 4
27 Correlation of Soluble ST2 With Golimumab (MK-8259) Response in Participants With Ulcerative Colitis (UC) (MK-8529-022). Completed NCT02318667 Phase 4
28 Rectal Tacrolimus in the Treatment of Resistant Ulcerative Proctitis Completed NCT01418131 Phase 4 Rectal tacrolimus;Placebo
29 The NOR-SWITCH Study Completed NCT02148640 Phase 4 Innovator infliximab;Biosimilar infliximab
30 Safety of Accelerated Infliximab Infusions in Patients With Inflammatory Bowel Disease (IBD) Completed NCT01346826 Phase 4 Standard 2 hours-infusion;Accelerated 1 hour-infusion;Accelerated 30 minutes-infusion
31 Treatment of Iron Deficiency Anaemia in Inflammatory Bowel Disease With Ferrous Sulphate Completed NCT01991314 Phase 4 Ferrous sulphate
32 Immunogenicity of Hepatitis A Vaccine in Inflammatory Bowel Disease (IBD) Patients Completed NCT01341808 Phase 4
33 The Influence of 5–Aminosalicylates on Thiopurine Metabolite Levels Completed NCT00167882 Phase 4 5-aminosalicylate (Pentasa, Ferring)
34 Single-dose Linaclotide for Capsule Endoscopy Preparation Completed NCT02465385 Phase 4 Linaclotide
35 Steroid-induced Mood Changes in Patients With Inflammatory Bowel Disease Completed NCT01981889 Phase 4 Prednisone
36 Efficacy Study of Pneumococcal Vaccination in Crohn's Disease Completed NCT01505855 Phase 4 23-valent polysaccharide pneumococcal vaccine
37 Intestinal Inflammation in Ankylosing Spondylitis and the Effects of Adalimumab on Mucosal Healing Completed NCT01174186 Phase 4 Adalimumab
38 Immune Response to the Human Papillomavirus Vaccine in Young Women With Inflammatory Bowel Disease Completed NCT01034358 Phase 4
39 A Trial of Iron Replacement in Patients With Iron Deficiency. Completed NCT01067547 Phase 4 Iron Sucrose.;Iron sucrose
40 Induction of Immunity Against Streptococcus Pneumoniae in Adults With Inflammatory Bowel Disease Completed NCT01908283 Phase 4
41 Use of a Novel Diet (UC DIET) for Treatment of Mild to Moderate Active Pediatric Ulcerative Colitis Recruiting NCT02345733 Phase 4 Antibiotic cocktail
42 Optimising Infliximab Induction Therapy for Acute Severe Ulcerative Colitis Recruiting NCT02770040 Phase 4 Infliximab
43 Corticosteroids+5-aminosalicylic Acid Compared to Corticosteroids in the Treatment of Moderate-severe Ulcerative Colitis Recruiting NCT01941589 Phase 4 oral 5-ASA+/-topical 5-ASA+IV corticosteroids / PO Methylprednisolone;corticosteroids only
44 Mesalazine With Hydrocortisone Sodium Succinate Enema for 4-Week Treatment in Patients With Ulcerative Colitis Recruiting NCT03110198 Phase 4 Mesalazine;hydrocortisone sodium succinate;Mesalazine with hydrocortisone sodium succinate
45 Fecal Microbiota Transplantation for Ulcerative Colitis Through Colonic Transendoscopic Enteral Tubing Recruiting NCT02998112 Phase 4 fecal microbiota transplantation;Saline
46 An Open Label Single-arm Phase 4 Study of Vedolizumab in Subjects With Newly Diagnosed Active Ulcerative Colitis Recruiting NCT03237260 Phase 4 Vedolizumab
47 Two Therapeutic Strategies for the Maintenance of Remission in Patients With Ulcerative Colitis Recruiting NCT03151525 Phase 4 Azathioprine;Infliximab
48 Extended Access Program of Vedolizumab IV in Ulcerative Colitis and Crohn's Disease Recruiting NCT02743806 Phase 4 Vedolizumab
49 Vedolizumab Intravenous (IV) Dose Optimization in Ulcerative Colitis Recruiting NCT03029143 Phase 4 Vedolizumab IV
50 A Research Study to Bank Samples for Future Evaluation to Identify Biomarkers That Predispose Crohn's Disease and Ulcerative Colitis Patients to Develop Hepatosplenic T-Cell Lymphoma (HSTCL) Recruiting NCT01804166 Phase 4 Infliximab;Golimumab

Search NIH Clinical Center for Ulcerative Colitis

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Ulcerative Colitis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Ulcerative Colitis:
MultiStem
Regenerative ColoTherapy
Embryonic/Adult Cultured Cells Related to Ulcerative Colitis:
Bone marrow-derived adherent progenitor cells (MultiStem) PMIDs: 21175285
Adipose-derived mesenchymal stem cells (family)
Peripheral blood-derived hematopoietic stem cells (family)

Cochrane evidence based reviews: colitis, ulcerative

Genetic Tests for Ulcerative Colitis

Anatomical Context for Ulcerative Colitis

The Foundational Model of Anatomy Ontology organs/tissues related to Ulcerative Colitis:

18
Colon

MalaCards organs/tissues related to Ulcerative Colitis:

38
Colon, Testes, T Cells, Liver, Bone, Neutrophil, Skin
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Ulcerative Colitis:
# Tissue Anatomical CompartmentCell Relevance
1 Bone Bone Marrow Bone Marrow Stromal Cells Potential therapeutic candidate

Publications for Ulcerative Colitis

Articles related to Ulcerative Colitis:

(show top 50) (show all 2518)
# Title Authors Year
1
Peroxiredoxin 1 expression in active ulcerative colitis mucosa identified by proteome analysis and involvement of thioredoxin based on immunohistochemistry. ( 29434945 )
2018
2
Introducing Traditional Herbal Medicine into Conventional Health Care in Treating Ulcerative Colitis: Primum Non Nocere. ( 29425926 )
2018
3
Molecular Comparison of Adult and Pediatric Ulcerative Colitis Indicates Broad Similarity of Molecular Pathways in Disease Tissue. ( 29401083 )
2018
4
Ulcerative colitis followed by the development of typical intestinal BehAset disease: A case report. ( 29443756 )
2018
5
Ileal pouch of ulcerative colitis and familial adenomatous polyposis patients exhibit modulation of autophagy markers. ( 29422639 )
2018
6
Impact of Cigarette Smoking on the Gastrointestinal Tract Inflammation: Opposing Effects in Crohn's Disease and Ulcerative Colitis. ( 29441064 )
2018
7
Hyperbaric oxygen therapy for pyoderma gangrenosum associated with ulcerative colitis. ( 29422812 )
2018
8
Efficacy and Safety of Adalimumab in Pediatric Ulcerative Colitis: A Real-life Experience from the SIGENP-IBD Registry. ( 29315163 )
2018
9
The possible relationship between Campylobacter spp./Arcobacter spp. and patients with ulcerative colitis. ( 29432367 )
2018
10
MicroRNA-31 and MicroRNA-155 Are Overexpressed in Ulcerative Colitis and Regulate IL-13 Signaling by Targeting Interleukin 13 Receptor I+-1. ( 29438285 )
2018
11
Psychological distress, iron deficiency, active disease and female gender are independent risk factors for fatigue in patients with ulcerative colitis. ( 29435325 )
2018
12
Cytomegalovirus Infection in Pediatric Severe Ulcerative Colitis-A Multicenter Study from the Pediatric Inflammatory Bowel Disease Porto Group of the European Society of Pediatric Gastroenterology, Hepatology and Nutrition. ( 29424814 )
2018
13
Partial to complete abrogation of the subepithelial macrophage barrier against the gut microbiota in patients with ulcerative colitis and Crohn's colitis. ( 29023984 )
2018
14
T-cell immune response against cytomegalovirus in peripheral blood and colonic mucosa from ulcerative colitis and Crohn's disease patients. ( 29422814 )
2018
15
Duodenal amyloidosis secondary to ulcerative colitis. ( 29422811 )
2018
16
Histological features of ileitis differentiating pediatric Crohn disease from ulcerative colitis with backwash ileitis. ( 29089273 )
2018
17
Ulcerative colitis: yet another paradoxical effect of tumour necrosis factor blockers? ( 29441549 )
2018
18
A case of pemphigus vulgaris associated with ulcerative colitis. ( 29422810 )
2018
19
Systematic Review With Meta-Analysis: Anti-TNF Therapy in Refractory Pouchitis and Crohn's Disease-Like Complications of the Pouch After Ileal Pouch-Anal Anastomosis Following Colectomy for Ulcerative Colitis. ( 29361101 )
2018
20
A data-based hypothesis explicating the observations that "Smoking is associated with risk for developing inflammatory bowel disease including late onset ulcerative colitis: a prospective study". ( 29447017 )
2018
21
Efficacy of Bifidobacterium breve Fermented Milk in Maintaining Remission of Ulcerative Colitis. ( 29450747 )
2018
22
Efficacy and safety of a novel high-dose mesalazine tablet in mild to moderate active ulcerative colitis: a double-blind, multicentre, randomised trial. ( 29435324 )
2018
23
Editorial: infliximab trough levels and histological healing in ulcerative colitis-a step towards personalised biologic therapy. ( 29446129 )
2018
24
Fecal immunochemical test for predicting mucosal healing in ulcerative colitis patients: A systematic review and meta-analysis. ( 29427297 )
2018
25
Long-interval Cytapheresis as a Novel Therapeutic Strategy Leading to Dosage Reduction and Discontinuation of Steroids in Steroid-dependent Ulcerative Colitis. ( 28924114 )
2017
26
Functional variant in the promoter region of IL-27 alters gene transcription and confers a risk for ulcerative colitis in northern Chinese Han. ( 28069403 )
2017
27
Metachronous metastatic colonic small cell carcinoma and recurrent adenocarcinoma in a patient with ulcerative colitis. ( 29423143 )
2017
28
Factors associated with early outcomes following standardised therapy in children with ulcerative colitis (PROTECT): a multicentre inception cohort study. ( 28939374 )
2017
29
The effect of CYP3A5 genetic polymorphisms on adverse events in patients with ulcerative colitis treated with tacrolimus. ( 27717793 )
2017
30
Plasma microRNA Profile Differentiates Crohn's Colitis From Ulcerative Colitis. ( 29272478 )
2017
31
Palisaded Granulomatous Dermatitis Associated with Ulcerative Colitis: A Comprehensive Literature Review. ( 28168136 )
2017
32
Garidisan: Improving the Quality of Ulcer Healing in Rats with Ulcerative Colitis. ( 28928792 )
2017
33
Human herpesvirus-8 positive iatrogenic Kaposi's sarcoma in the setting of refractory ulcerative colitis. ( 29291200 )
2017
34
Disseminated Nocardiosis Associated with Treatment with Infliximab in a Patient with Ulcerative Colitis. ( 29263313 )
2017
35
Oligoclonal T-cell Receptor Repertoire in Colonic Biopsies of Patients with Microscopic Colitis and Ulcerative Colitis. ( 28498152 )
2017
36
Association of ulcerative colitis with transcobalamin II gene polymorphisms and serum homocysteine, vitamin B12, and folate levels in Chinese patients. ( 28526947 )
2017
37
Preoperative Extraintestinal Manifestations Associated with Chronic Pouchitis in Japanese Patients with Ulcerative Colitis After Ileal Pouch-anal Anastomosis: A Retrospective Study. ( 28346273 )
2017
38
Activation of NLRP3 Inflammasome in Inflammatory Bowel Disease: Differences Between Crohn's Disease and Ulcerative Colitis. ( 28523573 )
2017
39
Non-granulomatous myositis in a patient with ulcerative colitis who showed symptoms resembling gastrocnemius myalgia syndrome. ( 28132973 )
2017
40
Long-term Extent Change of Pediatric-Onset Ulcerative Colitis. ( 28067753 )
2017
41
[Association of solute-linked carrier family 26 member A3 gene polymorphisms with ulcerative colitis among Chinese patients]. ( 28397232 )
2017
42
Effect of threatening life experiences and adverse family relations in ulcerative colitis: analysis using structural equation modeling and comparison with Crohn's disease. ( 28059861 )
2017
43
Interleukin-13 Inhibits Expression of cyp27b1 in Peripheral CD14+ Cells That Is Correlated With Vertebral Bone Mineral Density of Patients With Ulcerative Colitis. ( 27381199 )
2017
44
Ulcerative colitis with acute pleurisy: A case report and review of the literature. ( 28746225 )
2017
45
Detection of enterotoxigenic Bacteroides fragilis in patients with ulcerative colitis. ( 28924454 )
2017
46
Mucosal Healing in Ulcerative Colitis: A Comprehensive Review. ( 28078646 )
2017
47
Effectiveness and Safety of Golimumab in Treating Outpatient Ulcerative Colitis: A Real-Life Prospective, Multicentre, Observational Study in Primary Inflammatory Bowel Diseases Centers. ( 28922435 )
2017
48
The Changing Face of Pediatric Ulcerative Colitis: A Population-based Cohort Study. ( 29135823 )
2017
49
Acute infection due to Mycobacterium marinum in a patient with ulcerative colitis and metabolic syndrome on infliximab therapy. ( 29258704 )
2017
50
Traditional Chinese medicine combination therapy for patients with steroid-dependent ulcerative colitis: study protocol for a randomized controlled trial. ( 28069051 )
2017

Variations for Ulcerative Colitis

Expression for Ulcerative Colitis

LifeMap Discovery
Genes differentially expressed in tissues of Ulcerative Colitis patients vs. healthy controls: 35 (show all 12)
# Gene Description Tissue Up/Dn Fold Change (log2) P value
1 CLDN8 claudin 8 Colon - 4.72 0.000
2 LCN2 lipocalin 2 Colon + 4.60 0.000
3 REG3A regenerating islet-derived 3 alpha Colon + 4.41 0.001
4 SLC26A2 solute carrier family 26 (anion exchanger), member 2 Colon - 4.19 0.000
5 PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) Colon - 4.13 0.000
6 CXCL8 chemokine (C-X-C motif) ligand 8 Colon + 3.86 0.003
7 CXCL2 chemokine (C-X-C motif) ligand 2 Colon + 3.85 0.000
8 REG1A regenerating islet-derived 1 alpha Colon + 3.68 0.005
9 RGS3 regulator of G-protein signaling 3 Colon + 3.58 0.000
10 CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) Colon + 3.55 0.000
11 OLFM4 olfactomedin 4 Colon + 3.25 0.014
12 DEFA6 defensin, alpha 6, Paneth cell-specific Colon + 3.22 0.003
Search GEO for disease gene expression data for Ulcerative Colitis.

Pathways for Ulcerative Colitis

Pathways related to Ulcerative Colitis according to KEGG:

36
# Name Kegg Source Accession
1 Cytokine-cytokine receptor interaction hsa04060
2 Jak-STAT signaling pathway hsa04630
3 Inflammatory bowel disease (IBD) hsa05321

Pathways related to Ulcerative Colitis according to GeneCards Suite gene sharing:

(show all 43)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.02 CRP CTNNB1 CXCL8 IL10 IL10RA IL1B
2
Show member pathways
13.37 CXCL8 IL10 IL10RA IL1B IL2 IL23R
3
Show member pathways
13.21 CTNNB1 CXCL8 IL10 IL10RA IL1B IL2
4
Show member pathways
12.98 ATG16L1 CXCL8 IL1B MUC2 NOD2 TNF
5
Show member pathways
12.85 ABCB1 CXCL8 IL10 IL1B IL2 TNF
6 12.84 CTNNB1 CXCL8 IL2 IL23R MLH1 MSH2
7
Show member pathways
12.75 ABCB1 CTNNB1 MLH1 MUC2 REG4
8 12.58 IL10 IL1B IL2 MPO TNF
9
Show member pathways
12.55 IL10 IL1B IL2 IL23R NOD2 TNF
10
Show member pathways
12.54 CXCL8 IL10 IL1B IL2 TNF
11
Show member pathways
12.36 IL10 IL10RA IL2 IL23R
12
Show member pathways
12.34 CRP IL1B IL2 MPO TNF
13
Show member pathways
12.25 IL10 IL10RA IL1B IRGM TNF
14 12.2 IL10 IL10RA IL1B NOD2 TNF
15 12.19 CTNNB1 MLH1 MSH2 TNF
16 12.12 CTNNB1 CXCL8 IL10 IL1B TNF
17
Show member pathways
12.06 CXCL8 IL10 IL1B IL2 TNF
18 12.01 CXCL8 IL1B IL2 TNF
19 11.99 IL10 IL2 MPO TNF
20 11.89 CXCL8 IL10 IL1B IL23R TNF
21 11.87 IL10 IL10RA IL2 IL23R
22
Show member pathways
11.82 IL10 IL1B IL2 IL23R TNF
23
Show member pathways
11.81 CTNNB1 IL10 IL10RA IL1B IL2 IL23R
24 11.77 CXCL8 IL10 IL1B TNF
25
Show member pathways
11.75 CXCL8 IL2 TNF
26 11.75 IL10 IL1B IL2 TNF
27 11.7 CXCL8 IL10 IL1B MUC2 TNF
28 11.66 CXCL8 IL1B TNF
29
Show member pathways
11.62 CXCL8 IL1B IL2 TNF
30 11.6 CXCL8 IL1B TNF
31 11.53 IL1B IL2 TNF
32 11.47 CXCL8 IL10 IL1B TNF
33 11.46 IL10 IL1B IL2 IL23R TNF
34
Show member pathways
11.44 ABCB1 MLH1 MSH2
35
Show member pathways
11.38 IL10 IL2 TNF
36 11.36 IL10 IL1B TNF
37 11.26 MLH1 MPO MSH2
38 11.21 IL10 IL10RA IL1B TNF
39 11.2 CXCL8 IL10 IL1B IL2 TNF
40 11.05 CRP CXCL8 TNF
41 11.04 CXCL8 IL10 IL10RA IL1B TNF
42 11.03 IL10 IL1B IL2 TNF
43 10.94 IL1B MPO TNF

GO Terms for Ulcerative Colitis

Cellular components related to Ulcerative Colitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mismatch repair complex GO:0032300 8.62 MLH1 MSH2

Biological processes related to Ulcerative Colitis according to GeneCards Suite gene sharing:

(show all 43)
# Name GO ID Score Top Affiliating Genes
1 regulation of receptor activity GO:0010469 9.99 CXCL8 IL10 IL1B IL2 TNF UCN
2 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.92 CTNNB1 IL1B NOD2 TNF
3 defense response GO:0006952 9.89 CXCL8 MPO NOD2 TNF
4 defense response to bacterium GO:0042742 9.88 IL10 IRGM MPO NOD2 TNF
5 cellular response to lipopolysaccharide GO:0071222 9.87 CXCL8 IL10 IRGM TNF
6 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.86 IRGM TNF UCN
7 cellular response to organic cyclic compound GO:0071407 9.85 IL1B NOD2 TNF
8 positive regulation of JNK cascade GO:0046330 9.85 IL1B NOD2 TNF
9 response to lipopolysaccharide GO:0032496 9.85 IL10 IL10RA IL1B IL23R MPO
10 response to glucocorticoid GO:0051384 9.84 IL10 TNF UCN
11 positive regulation of DNA binding transcription factor activity GO:0051091 9.84 CTNNB1 IL10 IL1B TNF
12 positive regulation of T cell proliferation GO:0042102 9.83 IL1B IL2 IL23R
13 positive regulation of protein phosphorylation GO:0001934 9.8 IL1B IL2 IRGM TNF UCN
14 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.79 MLH1 MSH2 TNF
15 positive regulation of interleukin-8 production GO:0032757 9.7 IL1B NOD2 TNF
16 response to molecule of bacterial origin GO:0002237 9.69 CXCL8 IL10
17 maintenance of gastrointestinal epithelium GO:0030277 9.69 MUC2 NOD2
18 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.68 IL1B IL23R
19 negative regulation of lipid storage GO:0010888 9.67 CRP TNF
20 regulation of synapse organization GO:0050807 9.67 IL10 IL10RA
21 positive regulation of chemokine biosynthetic process GO:0045080 9.66 IL1B TNF
22 endothelial cell apoptotic process GO:0072577 9.65 IL10 TNF
23 regulation of establishment of endothelial barrier GO:1903140 9.64 IL1B TNF
24 nucleotide-binding oligomerization domain containing 2 signaling pathway GO:0070431 9.64 IRGM NOD2
25 negative regulation of cytokine secretion involved in immune response GO:0002740 9.63 IL10 TNF
26 positive regulation of isotype switching to IgA isotypes GO:0048298 9.61 MLH1 MSH2
27 somatic recombination of immunoglobulin gene segments GO:0016447 9.61 MLH1 MSH2
28 negative regulation of growth of symbiont in host GO:0044130 9.61 IL10 MPO TNF
29 positive regulation of fever generation GO:0031622 9.6 IL1B TNF
30 sequestering of triglyceride GO:0030730 9.58 IL1B TNF
31 protein lipidation involved in autophagosome assembly GO:0061739 9.58 ATG16L1 IRGM
32 receptor biosynthetic process GO:0032800 9.56 IL10 TNF
33 positive regulation of interleukin-6 production GO:0032755 9.56 IL1B NOD2 TNF UCN
34 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.55 IL1B TNF
35 positive regulation of interleukin-17 production GO:0032740 9.54 IL2 IL23R NOD2
36 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.5 IL10 IL1B TNF
37 somatic recombination of immunoglobulin genes involved in immune response GO:0002204 9.49 MLH1 MSH2
38 positive regulation of isotype switching to IgG isotypes GO:0048304 9.33 IL2 MLH1 MSH2
39 positive regulation of interferon-gamma production GO:0032729 9.26 IL1B IL2 IL23R TNF
40 inflammatory response GO:0006954 9.23 CRP CXCL8 IL10 IL1B IL23R IRGM
41 positive regulation of transcription by RNA polymerase II GO:0045944 10.19 CTNNB1 IL10 IL1B IL2 NOD2 TNF
42 immune response GO:0006955 10.08 CXCL8 IL10 IL1B IL2 TNF
43 positive regulation of gene expression GO:0010628 10.03 CRP CTNNB1 IL1B TNF UCN

Molecular functions related to Ulcerative Colitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.91 ABCB1 ATG16L1 CRP CTNNB1 CXCL8 IL10
2 ATPase activity GO:0016887 9.56 ABCB1 MLH1 MSH2 MYO9B
3 mismatched DNA binding GO:0030983 9.32 MLH1 MSH2
4 guanine/thymine mispair binding GO:0032137 9.16 MLH1 MSH2
5 cytokine activity GO:0005125 9.02 CXCL8 IL10 IL1B IL2 TNF

Sources for Ulcerative Colitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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