UC
MCID: ULC004
MIFTS: 72

Ulcerative Colitis (UC) malady

Gastrointestinal diseases category

Summaries for Ulcerative Colitis

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33MedlinePlus, 3CDC, 21Genetics Home Reference, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 Ulcerative colitis (uc) is a disease that causes inflammation and sores, called ulcers, in the lining of the rectum and colon. it is one of a group of diseases called inflammatory bowel disease. uc can happen at any age, but it usually starts between the ages of 15 and 30. it tends to run in families. the most common symptoms are pain in the abdomen and blood or pus in diarrhea. other symptoms may include anemia severe tiredness weight loss loss of appetite bleeding from the rectum sores on the skin joint pain growth failure in children about half of people with uc have mild symptoms. doctors use blood tests, stool tests, colonoscopy or sigmoidoscopy, and imaging tests to diagnose uc. several types of drugs can help control it. some people have long periods of remission, when they are free of symptoms. in severe cases, doctors must remove the colon. nih: national institute of diabetes and digestive and kidney diseases

MalaCards: Ulcerative Colitis, also known as idiopathic proctocolitis, is related to crohn's disease and inflammatory bowel disease. An important gene associated with Ulcerative Colitis is IL2 (interleukin 2), and among its related pathways are PAK Pathway and Immune response Fc epsilon RI pathway. The drugs azathioprine and hydrocortisone and the compounds peptidoglycan and prednisolone have been mentioned in the context of this disorder. Affiliated tissues include colon, testes and skin, and related mouse phenotypes are immune system and hematopoietic system.

CDC:3 Inflammatory Bowel Diseases (IBD) is a broad term that describes conditions with chronic or recurring immune response and inflammation of the gastrointestinal tract. The two most common inflammatory bowel diseases are ulcerative colitis and Crohn’s disease.

Genetics Home Reference:21 Ulcerative colitis is a chronic disorder that affects the digestive system. This condition is characterized by abnormal inflammation of the inner surface of the rectum and colon, which make up most of the length of the large intestine. The inflammation usually causes open sores (ulcers) to develop in the large intestine. Ulcerative colitis usually appears between ages 15 and 30, although it can develop at any age. The inflammation tends to flare up multiple times throughout life, which causes recurring signs and symptoms.

Wikipedia:63 Ulcerative colitis (Colitis ulcerosa, UC) is a form of inflammatory bowel disease (IBD). Ulcerative... more...

Description from OMIM:46 266600

Aliases & Classifications for Ulcerative Colitis

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Sources:
8Disease Ontology, 21Genetics Home Reference, 10DISEASES, 33MedlinePlus, 30LifeMap Discovery™, 60UMLS, 44Novoseek, 56SNOMED-CT, 39NCIt, 34MeSH, 27ICD9CM, 46OMIM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

ulcerative colitis 8 21 10 33 30 60
idiopathic proctocolitis 21 60
inflammatory bowel disease, ulcerative colitis type 21
chronic left-sided ulcerative colitis 60
left-sided ulcerative colitis 8
colitis ulcerative 44
colitis gravis 21
uc 21


External Ids:

Disease Ontology8 DOID:8577
NCIt39 C2952
MeSH34 D003093
ICD9CM27 556, 556.9
OMIM46 266600
ICD1025 K51

Related Diseases for Ulcerative Colitis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Ulcerative Colitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 323)
idRelated DiseaseScoreTop Affiliating Genes
1crohn's disease31.6TNFSF15, TNF, NKX2-3, NOD2
2inflammatory bowel disease31.1CCL11, TNFSF15, TNF, CTSG, MYO9B, MUC2
3colorectal cancer31.1NOD2, IL2, MUC2
4arthritis30.7TNF, CTSG, NOD2
5dermatitis30.7NOD2, CCL11
6rheumatoid arthritis30.6CCL11, TNF, CTSG, IL2, NOD2
7celiac disease30.5MYO9B
8bronchiolitis30.5CCL11
9dermatitis herpetiformis30.5CCL11
10sarcoidosis30.3NOD2, IL2, BTNL2, TNF, CCL11
11uveitis30.3NOD2, TNF, CCL11
12ankylosing spondylitis30.3TNF
13spondylitis30.3NOD2
14wegener's granulomatosis30.3CTSG
15tuberculosis30.3TNF, CTSG, IL2, NOD2
16glomerulonephritis30.2CTSG
17systemic lupus erythematosus30.0NOD2, IL2, CTSG, TNF
18cholera29.9CCL11, MUC2
19peritonitis29.9CTSG, TNF
20sclerosing cholangitis10.9
21cholangitis10.9
22megacolon10.8
23toxic megacolon10.8
24proctitis10.8
25pyoderma10.7
26pyoderma gangrenosum10.7
27colonic disease10.6
28familial adenomatous polyposis10.6
29hepatitis10.6
30cerebritis10.6
31intestinal disease10.6
32pericholangitis10.6
33adenocarcinoma10.6
34colon cancer10.5
35duodenal ulcer10.5
36duodenitis10.5
37hepatitis a10.5
38irritable bowel syndrome10.4
39adenoma10.4
40bile duct carcinoma10.4
41pancreatitis10.4
42pneumonia10.4
43vasculitis10.4
44takayasu's arteritis10.4
45portal vein thrombosis10.4
46autoimmune hemolytic anemia10.4
47autoimmune hepatitis10.4
48gastroduodenitis10.4
49diarrhea10.4
50hemolytic anemia10.4

Graphical network of the top 20 diseases related to Ulcerative Colitis:



Diseases related to ulcerative colitis

Clinical Features for Ulcerative Colitis

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Sources:
46OMIM
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Clinical features from OMIM:

266600

Drugs & Therapeutics for Ulcerative Colitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Ulcerative Colitis

Drug clinical trials:

Search ClinicalTrials for Ulcerative Colitis

Search NIH Clinical Center for Ulcerative Colitis

Search CenterWatch for Ulcerative Colitis

Inferred drug relations via UMLS60/NDF-RT40:

Show with subtypes

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Ulcerative Colitis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Ulcerative Colitis:
MultiStem
Embryonic/Adult Cultured Cells Related to Ulcerative Colitis:
Bone marrow-derived adherent progenitor cells (MultiStem)

Genetic Tests for Ulcerative Colitis

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Anatomical Context for Ulcerative Colitis

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30LifeMap Discovery™, 32MalaCards
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MalaCards organs/tissues related to Ulcerative Colitis:

32
Colon, Testes, Skin, T cells, Kidney, Bone, Liver, Monocytes, Bone marrow, Endothelial, Thyroid, Appendix, B cells, Myeloid, Whole blood, Smooth muscle, Prostate, Pancreas, Spinal cord, Breast, Lymph node, Eye, Lung, Thymus

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Ulcerative Colitis:
id TissueAnatomical CompartmentCell Relevance
1 BoneBone MarrowBone Marrow Stromal Cells Potential therapeutic candidate

Animal Models for Ulcerative Colitis or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Ulcerative Colitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538712.1NOD2, CCL11, CARD9, TNFSF15, TNF, CTSG
2MP:000539711.7CTSG, TNF, TNFSF15, CCL11, NKX2-3, MYO9B
3MP:000538111.4NKX2-3, MUC2, CLDN18, IL2, NOD2, TNF

Publications for Ulcerative Colitis

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Sources:
50PubMed
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Articles related to Ulcerative Colitis:

(show top 50)    (show all 2034)
idTitleAuthorsYear
1
Differential Effect of Genetic Burden on Disease Phenotypes in Crohn's Disease and Ulcerative Colitis: Analysis of a North American Cohort. (24419484)
2014
2
Oral tacrolimus as maintenance therapy for refractory ulcerative colitis--an analysis of outcomes in two London tertiary centres. (23623737)
2013
3
Seasonal variations in the onset of ulcerative colitis in Japan. (24379632)
2013
4
Ulcerative colitis: current and future treatment strategies. (23797129)
2013
5
Influence of polymorphisms and TNF and IL1I^ serum concentration on the infliximab response in Crohn's disease and ulcerative colitis. (22960943)
2013
6
Comparison of fracture risk between patients with ileal pouch-anal anastomosis for ulcerative colitis and the general population. (23871399)
2013
7
Ethnicity differences in genetic susceptibility to ulcerative colitis: a comparison of Indian asians and white northern Europeans. (24145928)
2013
8
Total colectomy for ulcerative colitis in children: when are we operating? (23571824)
2013
9
Immunohistochemical analysis of chromogranin A and p53 expressions in ulcerative colitis-associated neoplasia: neuroendocrine differentiation as an early event in the colitis-neoplasia sequence. (24029705)
2013
10
Increased suppressor of cytokine signaling-3 expression predicts mucosal relapse in ulcerative colitis. (22535619)
2013
11
NOD2 gene mutations associate weakly with ulcerative colitis but not with Crohn's disease in Indian patients with inflammatory bowel disease. (23085276)
2013
12
Combined oral and rectal mesalazine for the treatment of mild-to-moderately active ulcerative colitis: Rapid symptom resolution and improvements in quality of life. (24012063)
2013
13
Dysregulated Tim-3 expression and its correlation with imbalanced CD4 helper T cell function in ulcerative colitis. (23117395)
2012
14
Filiform ulcerative colitis-rare entity captured. (23600065)
2012
15
IL-6 promotes immune responses in human ulcerative colitis and induces a skin-homing phenotype in the dendritic cells and Tcells they stimulate. (22539302)
2012
16
Altered O-glycosylation profile of MUC2 mucin occurs in active ulcerative colitis and is associated with increased inflammation. (21290483)
2011
17
Ulcerative colitis complicated by atypical peristomal pyoderma gangrenosum. (21630389)
2011
18
Natural history of cytomegalovirus infection in a series of patients diagnosed with moderate-severe ulcerative colitis. (21350712)
2011
19
Analysis of the influence of two CD24 genetic variants in Crohn's disease and ulcerative colitis. (21684315)
2011
20
Risk of cancer in patients with chronic pouchitis after restorative proctocolectomy for ulcerative colitis. (19832871)
2011
21
Epithelial-derived IL-33 and its receptor ST2 are dysregulated in ulcerative colitis and in experimental Th1/Th2 driven enteritis. (20385815)
2010
22
The relationship between the expression of the glucocorticoid receptor in biopsied colonic mucosa and the glucocorticoid responsiveness of ulcerative colitis patients. (19646928)
2009
23
Plasma carnitine ester profiles in Crohn's disease and ulcerative colitis patients with different IGR2230a_1 genotypes. (19735486)
2009
24
Effect of the polymorphism of tumor necrosis factor-alpha-308 G/A gene promoter on the susceptibility to ulcerative colitis: a meta-analysis. (18827481)
2008
25
Development of pouchitis following ileal pouch-anal anastomosis (IPAA) for ulcerative colitis: A role for serological markers and microbial pattern recognition receptor genes. (21172204)
2008
26
Elevated insulin-like growth factor 1 receptor, hepatocyte growth factor receptor and telomerase protein expression in mild ulcerative colitis. (18938767)
2008
27
The role of IL-13 and NK T cells in experimental and human ulcerative colitis. (19079225)
2008
28
Heat shock protein gene 70-2 polymorphism is differentially associated with the clinical phenotypes of ulcerative colitis and Crohn's disease. (17532782)
2007
29
Stress maladjustment in the pathoetiology of ulcerative colitis. (17653646)
2007
30
Perinuclear antineutrophil cytoplasmic antibody myeloperoxidase-positive vasculitis in association with ulcerative colitis. (15902516)
2006
31
Takayasu's arteritis and ulcerative colitis in a young non-Asian woman: a rare association. (16363285)
2005
32
Functional annotation of a novel NFKB1 promoter polymorphism that increases risk for ulcerative colitis. (14613970)
2004
33
Over-expression of interleukin 10 in mucosal T cells of patients with active ulcerative colitis. (12974765)
2003
34
Ca2+ response in neutrophils after exposure to bacterial N-formyl-methionyl-leucyl-phenylalanine: delayed response in ulcerative colitis. (12610322)
2003
35
Activation of nuclear factor-kappaB and its relationship with cytokine gene expression in colonic mucosa of ulcerative colitis patients]. (12133438)
2002
36
Possible involvement of neutrophil elastase in impaired mucosal repair in patients with ulcerative colitis. (12572862)
2002
37
Common carotid artery occlusion causing cerebral infarction in ulcerative colitis. (12118932)
2002
38
Pouchitis-associated iritis (uveitis) following total proctocolectomy and ileal pouch-to-anal anastomosis in ulcerative colitis. (11240384)
2001
39
A family with collagenous colitis, ulcerative colitis, and Crohn's disease. (11151908)
2000
40
Differential levels of granzyme B, regulatory cytokines, and apoptosis in Crohn's disease and ulcerative colitis at first presentation. (10657017)
2000
41
Mesalazine inhibits activation of transcription factor NF-kappaB in inflamed mucosa of patients with ulcerative colitis. (11151876)
2000
42
Application of IL-1 beta and 8 mRNA and some other indices in monitoring the activity of ulcerative colitis]. (12567438)
1999
43
Evidence of linkage of the inflammatory bowel disease susceptibility locus on chromosome 16 (IBD1) to ulcerative colitis. (9541106)
1998
44
Treatment of ulcerative colitis with an engineered human anti-TNFalpha antibody CDP571. (9663825)
1997
45
Growth factor mRNA expression in normal colorectal mucosa and in uninvolved mucosa from ulcerative colitis patients. (8726826)
1996
46
Changes in substance P-immunoreactive innervation of human colon associated with ulcerative colitis. (7587798)
1995
47
Interleukin-2 production in pediatric inflammatory bowel disease: evidence for dissimilar mononuclear cell function in Crohn's disease and ulcerative colitis. (8271122)
1993
48
Circadian rhythmicity and cross correlation of plasma gastrin, cortisol and somatostatin levels in ulcerative colitis patients and healthy subjects. (8100796)
1993
49
Chronic ulcerative colitis and pericholangitis. (5427620)
1970
50
Liver in ulcerative colitis: obstructive jaundice due to bile duct carcinoma. (5929253)
1966

Genetic Variations for Ulcerative Colitis

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Expression for genes affiliated with Ulcerative Colitis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Ulcerative Colitis

Search GEO for disease gene expression data for Ulcerative Colitis.

Pathways for genes affiliated with Ulcerative Colitis

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Sources:
51QIAGEN, 12EMD Millipore, 29KEGG, 53Reactome, 37NCBI BioSystems Database
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Compounds for genes affiliated with Ulcerative Colitis

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 59Tocris Bioscience, 24HMDB, 49PharmGKB
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Compounds related to Ulcerative Colitis according to GeneCards/GeneDecks:

(show all 17)
idCompoundScoreTop Affiliating Genes
1peptidoglycan44 2812.4NOD2, CTSG, TNF, CCL11
2prednisolone44 28 1113.4NOD2, IL2, TNF, CCL11
3indomethacin44 59 28 1114.3CCL11, TNF, CTSG, IL2
4pranlukast44 28 1113.2CCL11, TNF, MUC2
5il 104411.2TNF, IL2, NOD2
6n-formylmethionyl-leucylphenylalanine4411.2CTSG, TNF, CCL11
7histamine44 28 2413.2CCL11, TNF, CTSG, IL2
8leukotriene b444 59 2413.1CTSG, TNF, CCL11
9interferon gamma4411.0TNF, IL2
10piclamilast44 1112.0IL2, TNF
11lenalidomide44 1112.0TNF, IL2
12taurine chloramine4410.9TNF, IL2
13endotoxin4410.9CTSG
14actinomycin d4410.8CCL11, TNF, MUC2, IL2
15toxin-14410.8IL2, TNF
16salmeterol44 49 28 1113.8IL2, CCL11
17gold sodium thiomalate4410.7IL2, TNF

GO Terms for genes affiliated with Ulcerative Colitis

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16Gene Ontology
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Biological processes related to Ulcerative Colitis according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of growth of symbiont in hostGO:04413011.2NOD2, CTSG, TNF
2defense response to Gram-positive bacteriumGO:05083011.1NOD2, TNF, CARD9
3positive regulation of interleukin-6 productionGO:03275511.1CARD9, TNF, NOD2
4immune responseGO:00695511.1IL2, CTSG, TNFSF15, CCL11
5positive regulation of JNK cascadeGO:04633011.1NOD2, TNF, CARD9
6positive regulation of humoral immune response mediated by circulating immunoglobulinGO:00292510.9TNF, NOD2
7response to muramyl dipeptideGO:03249510.9NOD2, CARD9
8positive regulation of stress-activated MAPK cascadeGO:03287410.8CARD9, NOD2
9positive regulation of interleukin-17 productionGO:03274010.7IL2, NOD2
10response to exogenous dsRNAGO:04333010.5NOD2, CARD9

Molecular functions related to Ulcerative Colitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1CARD domain bindingGO:05070010.8NOD2, CARD9

Products for genes affiliated with Ulcerative Colitis

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Sources for Ulcerative Colitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet