Aliases & Classifications for Ulcerative Colitis

MalaCards integrated aliases for Ulcerative Colitis:

Name: Ulcerative Colitis 38 12 25 41 3 14 69
Inflammatory Bowel Disease, Ulcerative Colitis Type 25
Chronic Left-Sided Ulcerative Colitis 69
Left-Sided Ulcerative Colitis 12
Left Sided Ulcerative Colitis 69
Idiopathic Proctocolitis 25
Colitis, Ulcerative 42
Colitis Ulcerative 52
Colitis Gravis 25
Uc 25

Classifications:



Summaries for Ulcerative Colitis

MedlinePlus : 41 ulcerative colitis (uc) is a disease that causes inflammation and sores, called ulcers, in the lining of the rectum and colon. it is one of a group of diseases called inflammatory bowel disease. uc can happen at any age, but it usually starts between the ages of 15 and 30. it tends to run in families. the most common symptoms are pain in the abdomen and blood or pus in diarrhea. other symptoms may include anemia severe tiredness weight loss loss of appetite bleeding from the rectum sores on the skin joint pain growth failure in children about half of people with uc have mild symptoms. doctors use blood tests, stool tests, colonoscopy or sigmoidoscopy, and imaging tests to diagnose uc. several types of drugs can help control it. some people have long periods of remission, when they are free of symptoms. in severe cases, doctors must remove the colon. nih: national institute of diabetes and digestive and kidney diseases

MalaCards based summary : Ulcerative Colitis, also known as inflammatory bowel disease, ulcerative colitis type, is related to crohn's colitis and psoriasis, and has symptoms including abdominal pain, constipation and diarrhea. An important gene associated with Ulcerative Colitis is NOD2 (Nucleotide Binding Oligomerization Domain Containing 2), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Infliximab and Iron have been mentioned in the context of this disorder. Affiliated tissues include Bone, colon and testes, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and digestive/alimentary

CDC : 3 Inflammatory Bowel Disease (IBD) is a broad term that describes conditions characterized by chronic inflammation of the gastrointestinal tract. The two most common inflammatory bowel diseases are ulcerative colitis and Crohn’s disease. Inflammation affects the entire digestive tract in Crohn’s disease and only the large intestine (also called the colon) in ulcerative colitis. Both illnesses involved an abnormal response to the body’s immune system.

Genetics Home Reference : 25 Ulcerative colitis is a chronic disorder that affects the digestive system. This condition is characterized by abnormal inflammation of the inner surface of the rectum and colon, which make up most of the length of the large intestine. The inflammation usually causes open sores (ulcers) to develop in the large intestine. Ulcerative colitis usually appears between ages 15 and 30, although it can develop at any age. The inflammation tends to flare up multiple times throughout life, which causes recurring signs and symptoms.

Disease Ontology : 12 A colitis that is predominantly confined to the mucosa located in colon and includes characteristic ulcers, or open sores.

Wikipedia : 72 Ulcerative colitis (UC) is a long-term condition that results in inflammation and ulcers of the colon... more...

Related Diseases for Ulcerative Colitis

Diseases related to Ulcerative Colitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 562)
id Related Disease Score Top Affiliating Genes
1 crohn's colitis 31.6 MYO9B NOD2 TNF
2 psoriasis 31.2 IL2 MLH1 MSH2
3 lymphoma 31.2 IL10 IL1B IL2 TNF
4 colorectal cancer 31.1 ABCB1 CTNNB1 CXCL8 IL10 IL1B IL2
5 membranoproliferative glomerulonephritis 30.7 IL2 NOD2 TNF
6 pericholangitis 30.7 CRP MPO MUC2 TNF
7 primary biliary cirrhosis 30.6 IL10 IL10RA TNF
8 alopecia 30.5 CXCL8 IL10 TNF
9 gastric ulcer 30.5 IL10 IL2 TNF
10 autoimmune polyglandular syndrome type 3 30.4 IL2 TNF
11 inner ear disease 30.2 CXCL8 IL10 TNF
12 hidradenitis 29.9 CRP CXCL8 IL1B
13 rheumatoid arthritis 29.8 CRP CXCL8 IL10 IL1B IL2 TNF
14 colon adenocarcinoma 29.4 CRP CXCL8 IL10 IL1B TNF
15 pulmonary embolism 29.4 CRP CXCL8 IL10 IL1B TNF
16 kaposi sarcoma 29.2 CRP IL1B TNF
17 systemic lupus erythematosus 28.6 CRP IL10 IL2 MPO TNF
18 microscopic colitis 27.0 ABCB1 ATG16L1 CTNNB1 CXCL8 IL10 IL10RA
19 pediatric ulcerative colitis 12.2
20 crohn disease-associated growth failure 11.6
21 inflammatory bowel disease 11.5
22 ulcerative proctitis 11.4
23 irritable bowel syndrome 11.3
24 pouchitis 11.3
25 pyoderma gangrenosum 11.3
26 colitis 11.2
27 bile duct carcinoma 11.2
28 colonic disease 11.2
29 scirrhous adenocarcinoma 11.1 IL2 TNF
30 inflammatory bowel disease 13 11.0
31 inflammatory bowel disease 14 11.0
32 inflammatory bowel disease 10 11.0
33 inflammatory bowel disease 28, early onset, autosomal recessive 11.0
34 inflammatory bowel disease 19 11.0
35 inflammatory bowel disease 17, protection against 11.0
36 inflammatory bowel disease 25, early onset, autosomal recessive 11.0
37 pure autonomic failure 11.0 IL10 TNF
38 autoimmune oophoritis 11.0 MPO TNF
39 spirillary rat-bite fever 11.0 CXCL8 IL2 TNF
40 tinea favosa 10.9 IL1B IL2 TNF
41 acute ackee fruit intoxication 10.9 IL10 TNF
42 microcephaly, short stature, and limb abnormalities 10.9 IL10 IL10RA
43 lip cancer 10.9 CXCL8 NOD2 TNF
44 myopathy 10.9 CXCL8 NOD2 TNF
45 yao syndrome 10.9 IL1B NOD2 TNF
46 idiopathic dilatation of the pulmonary artery 10.9 IL10 IL23R TNF
47 foodborne botulism 10.9 IL1B IL2 TNF
48 gastrointestinal neuroendocrine tumor 10.9 CTNNB1 MLH1 MUC2
49 congenital diaphragmatic hernia 10.9 CXCL8 IL2
50 allergic rhinitis 10.9 ATG16L1 IL23R MYO9B NOD2

Comorbidity relations with Ulcerative Colitis via Phenotypic Disease Network (PDN):


Active Peptic Ulcer Disease Acute Cystitis
Crohn's Disease Deficiency Anemia
Esophagitis Hypothyroidism
Intestinal Obstruction Iron Deficiency Anemia
Paralytic Ileus Protein-Energy Malnutrition

Graphical network of the top 20 diseases related to Ulcerative Colitis:



Diseases related to Ulcerative Colitis

Symptoms & Phenotypes for Ulcerative Colitis

UMLS symptoms related to Ulcerative Colitis:


abdominal pain, constipation, diarrhea, dyspepsia, heartburn, icterus, nausea and vomiting, gastrointestinal gas

GenomeRNAi Phenotypes related to Ulcerative Colitis according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.88 MYO9B NOD2 TNF CXCL8 IL10 IL1B
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.88 NOD2 TNF CXCL8 IL10 IL1B IL2

MGI Mouse Phenotypes related to Ulcerative Colitis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 10.15 ABCB1 ATG16L1 CTNNB1 IL10 IL10RA IL2
2 cellular MP:0005384 10.14 ATG16L1 CTNNB1 IL10 IL10RA IL2 MLH1
3 cardiovascular system MP:0005385 10.13 CTNNB1 IL10 IL1B IL2 MPO MUC2
4 hematopoietic system MP:0005397 10.1 ABCB1 ATG16L1 CTNNB1 IL10 IL10RA IL1B
5 homeostasis/metabolism MP:0005376 10.06 TNF UCN ABCB1 ATG16L1 CRP CTNNB1
6 endocrine/exocrine gland MP:0005379 9.97 ABCB1 ATG16L1 CTNNB1 IL10 IL2 IL23R
7 immune system MP:0005387 9.83 ATG16L1 CRP CTNNB1 IL10 IL10RA IL1B
8 neoplasm MP:0002006 9.28 CTNNB1 IL10 IL1B IL2 IL23R MLH1

Drugs & Therapeutics for Ulcerative Colitis

Drugs for Ulcerative Colitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 305)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Infliximab Approved Phase 4,Phase 2,Phase 3,Phase 1 170277-31-3
2
Iron Approved Phase 4,Phase 3,Phase 2 7439-89-6 23925
3
Azathioprine Approved Phase 4,Phase 2,Phase 3 446-86-6 2265
4
Prednisone Approved, Vet_approved Phase 4,Phase 2,Phase 3 53-03-2 5865
5
Adalimumab Approved Phase 4,Phase 3,Phase 2,Phase 1 331731-18-1 16219006
6
Aminosalicylic Acid Approved Phase 4,Phase 3,Phase 2,Phase 1 65-49-6 4649
7
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
8
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 2 22916-47-8 4189
9
Benzocaine Approved Phase 4,Phase 3,Phase 1 1994-09-7, 94-09-7 2337
10
Tacrolimus Approved, Investigational Phase 4,Phase 3,Phase 2 104987-11-3 445643 439492
11
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613 2171
12
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 2 564-25-0 54671203
13
Metronidazole Approved Phase 4,Phase 3,Phase 2,Phase 1 443-48-1 4173
14
Nicotine Approved Phase 4 54-11-5 942 89594
15
Hydrocortisone Approved, Vet_approved Phase 4,Phase 1,Phase 2 50-23-7 5754 657311
16
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 83-43-2 6741
17
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-24-8 5755
18 Vedolizumab Approved Phase 4,Phase 3,Phase 2 943609-66-3
19
Guaifenesin Approved, Vet_approved Phase 4,Phase 3,Phase 1 93-14-1 3516
20
Omeprazole Approved, Investigational, Vet_approved Phase 4,Phase 1,Phase 2 73590-58-6 4594
21
Vancomycin Approved Phase 4,Phase 1 1404-90-6 441141 14969
22
Methotrexate Approved Phase 4,Phase 2 1959-05-2, 59-05-2 126941
23
Dextromethorphan Approved Phase 4 125-71-3 5360696 5362449
24
Losartan Approved Phase 4 114798-26-4 3961
25
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
26
Copper Approved Phase 4 7440-50-8 27099
27
Zinc Approved Phase 4 7440-66-6 32051 23994
28
Thioguanine Approved Phase 4 154-42-7 2723601
29
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
30 tannic acid Approved, Nutraceutical Phase 4,Phase 3,Phase 1
31
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 1 59-30-3 6037
32
leucovorin Approved, Nutraceutical Phase 4,Phase 2 58-05-9 143 6006
33
Vitamin C Approved, Nutraceutical Phase 4 50-81-7 5785 54670067
34
Caffeine Approved, Nutraceutical Phase 4 58-08-2 2519
35 Tocopherol Approved, Nutraceutical Phase 4,Phase 2
36
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4,Phase 2 59-02-9 14985
37
Butyric Acid Experimental Phase 4,Phase 2 107-92-6 264
38
Angiotensin II Investigational Phase 4 68521-88-0, 4474-91-3, 11128-99-7 172198 65143
39
gamma-Aminobutyric acid Investigational Phase 4 56-12-2 119
40 Antibodies Phase 4,Phase 2,Phase 3,Phase 1
41 Antibodies, Monoclonal Phase 4,Phase 3,Phase 2,Phase 1
42 Immunoglobulins Phase 4,Phase 2,Phase 3,Phase 1
43 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1
44 Dermatologic Agents Phase 4,Phase 2,Phase 3,Phase 1
45 Gastrointestinal Agents Phase 4,Phase 2,Phase 3,Phase 1
46 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1
47 Analgesics Phase 4,Phase 3,Phase 2,Phase 1
48 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 2,Phase 1
49 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1
50 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 840)

id Name Status NCT ID Phase Drugs
1 Role of Healthy Bacteria in Ulcerative Colitis Unknown status NCT01479660 Phase 4 Probiotic
2 Physiological Intermolecular Modification Spectroscopy (PIMS) in Ulcerative Colitis With Golimumab Unknown status NCT02186886 Phase 4 Golimumab
3 Golimumab in Steroid-dependent Ulcerative Colitis: Induction and Maintenance of Clinical and Endoscopic Remission Unknown status NCT02412085 Phase 4 Golimumab
4 The Effect of Probiotics on the Rate of Recovery of Inflammatory Bowel Disease Exacerbation, Endothelial Function, and Markers of Inflammation Unknown status NCT01078935 Phase 4
5 Confocal Endomicroscopy During Endoscopy Unknown status NCT00988273 Phase 4
6 "Efficacy and Safety of Infliximab-biosimilar (Inflectra) Compared to Infliximab-innovator (Remicade) in Patients With Inflammatory Bowel Disease in Remission: the SIMILAR Trial" Unknown status NCT02452151 Phase 4 Infliximab-Biosimilar;Infliximab-Innovator
7 The Effect of Probiotics on Exacerbation of Inflammatory Bowel Disease Exacerbation (Crohn's Disease) Unknown status NCT01765998 Phase 4 Probiotic;Placebo
8 A Prospective, Placebo Controlled, Double-Blind, Cross-over Study on the Effects of a Probiotic Preparation (VSL#3) on Metabolic Profile, Intestinal Permeability, Microbiota, Cytokines and Chemokines Expression and Other Inflammatory Markers in Pediatric Unknown status NCT01632462 Phase 4 VSL#3
9 Manipulation of Visceral Sensitivity and Immune System in IBS Unknown status NCT00418340 Phase 4 probiotic (bacterial/dietary supplement)
10 Pain Relief In Irritable Bowel Syndrome Unknown status NCT02573844 Phase 4 Proklama
11 Treatment of Ulcerative Colitis With Ciprofloxacin and E. Coli Nissle Completed NCT01772615 Phase 4 Ciprofloxacin
12 A Long Term Safety Study of Infliximab (Remicade) in in Ulcerative Colitis Patients Completed NCT00207688 Phase 4 Infliximab 5 mg/kg;Infliximab 10 mg/kg;Placebo
13 Evaluation of Histologic and Endoscopic Remission Induced by Infliximab in Moderate to Severe Ulcerative Colitis Completed NCT01408810 Phase 4 Infliximab
14 Strategies in Maintenance for Patients Receiving Long-term Therapy (S.I.M.P.L.E.) With MMX (Multi-Matrix System) Mesalamine for Ulcerative Colitis (UC) Completed NCT00446849 Phase 4 MMX Mesalamine
15 Study Comparing Cyclosporine With Infliximab in Steroid-refractory Severe Attacks of Ulcerative Colitis Completed NCT00542152 Phase 4 CYCLOSPORINE VS INFLIXIMAB
16 European Safety Registry in Ulcerative Colitis (Study P04808AM3) Completed NCT00705484 Phase 4 Standard Therapy
17 Golimumab Utilization and Impact on Ulcerative Colitis (MK-8259-032) Completed NCT02092285 Phase 4 Golimumab
18 Once Versus Twice Daily Mesalamine to Induce Remission in Pediatric Ulcerative Colitis Completed NCT01201122 Phase 4 Mesalamine
19 Asacol Dosing Study for Active Ulcerative Colitis Completed NCT00194818 Phase 4 Asacol (mesalamine)
20 Preference for a Prefilled Syringe or Smartject™ Device for Delivering Golimumab in Participants Suffering From Moderate-to-severe Ulcerative Colitis (MK-8259-027) Completed NCT02155335 Phase 4 Prefilled Syringe delivery of Golimumab;Smartject Device delivery of Golimumab
21 Adacolumn in Refractory UC Patients Trial Completed NCT01481142 Phase 4
22 Dose Escalation and Remission (DEAR) Completed NCT00652145 Phase 4 mesalamine
23 Ability to Maintain or Achieve Clinical and Endoscopic Remission With MMX Mesalamine Once Daily in Adults With Ulcerative Colitis Completed NCT01124149 Phase 4 MMX mesalamine/ mesalazine
24 Study for the Treatment of Ulcerative Colitis With Adacolumn (Companion to US Study 512-04-205) Completed NCT00219414 Phase 4
25 Correlation of Soluble ST2 With Golimumab (MK-8259) Response in Participants With Ulcerative Colitis (UC) (MK-8529-022). Completed NCT02318667 Phase 4
26 Rectal Tacrolimus in the Treatment of Resistant Ulcerative Proctitis Completed NCT01418131 Phase 4 Rectal tacrolimus;Placebo
27 The NOR-SWITCH Study Completed NCT02148640 Phase 4 Innovator infliximab;Biosimilar infliximab
28 Safety of Accelerated Infliximab Infusions in Patients With Inflammatory Bowel Disease (IBD) Completed NCT01346826 Phase 4 Standard 2 hours-infusion;Accelerated 1 hour-infusion;Accelerated 30 minutes-infusion
29 Treatment of Iron Deficiency Anaemia in Inflammatory Bowel Disease With Ferrous Sulphate Completed NCT01991314 Phase 4 Ferrous sulphate
30 The Influence of 5–Aminosalicylates on Thiopurine Metabolite Levels Completed NCT00167882 Phase 4 5-aminosalicylate (Pentasa, Ferring)
31 Immunogenicity of Hepatitis A Vaccine in Inflammatory Bowel Disease (IBD) Patients Completed NCT01341808 Phase 4
32 Single-dose Linaclotide for Capsule Endoscopy Preparation Completed NCT02465385 Phase 4 Linaclotide
33 Steroid-induced Mood Changes in Patients With Inflammatory Bowel Disease Completed NCT01981889 Phase 4 Prednisone
34 Efficacy Study of Pneumococcal Vaccination in Crohn's Disease Completed NCT01505855 Phase 4 23-valent polysaccharide pneumococcal vaccine
35 Intestinal Inflammation in Ankylosing Spondylitis and the Effects of Adalimumab on Mucosal Healing Completed NCT01174186 Phase 4 Adalimumab
36 Immune Response to the Human Papillomavirus Vaccine in Young Women With Inflammatory Bowel Disease Completed NCT01034358 Phase 4
37 A Trial of Iron Replacement in Patients With Iron Deficiency. Completed NCT01067547 Phase 4 Iron Sucrose.;Iron sucrose
38 Induction of Immunity Against Streptococcus Pneumoniae in Adults With Inflammatory Bowel Disease Completed NCT01908283 Phase 4
39 Use of a Novel Diet (UC DIET) for Treatment of Mild to Moderate Active Pediatric Ulcerative Colitis Recruiting NCT02345733 Phase 4 Antibiotic cocktail
40 Optimising Infliximab Induction Therapy for Acute Severe Ulcerative Colitis Recruiting NCT02770040 Phase 4 Infliximab
41 Corticosteroids+5-aminosalicylic Acid Compared to Corticosteroids in the Treatment of Moderate-severe Ulcerative Colitis Recruiting NCT01941589 Phase 4 oral 5-ASA+/-topical 5-ASA+IV corticosteroids / PO Methylprednisolone;corticosteroids only
42 Mesalazine With Hydrocortisone Sodium Succinate Enema for 4-Week Treatment in Patients With Ulcerative Colitis Recruiting NCT03110198 Phase 4 Mesalazine;hydrocortisone sodium succinate;Mesalazine with hydrocortisone sodium succinate
43 Fecal Microbiota Transplantation for Ulcerative Colitis Through Colonic Transendoscopic Enteral Tubing Recruiting NCT02998112 Phase 4 fecal microbiota transplantation;Saline
44 An Open Label Single-arm Phase 4 Study of Vedolizumab in Subjects With Newly Diagnosed Active Ulcerative Colitis Recruiting NCT03237260 Phase 4 Vedolizumab
45 Extended Access Program of Vedolizumab IV in Ulcerative Colitis and Crohn's Disease Recruiting NCT02743806 Phase 4 Vedolizumab
46 Two Therapeutic Strategies for the Maintenance of Remission in Patients With Ulcerative Colitis Recruiting NCT03151525 Phase 4 Azathioprine;Infliximab
47 Vedolizumab Intravenous (IV) Dose Optimization in Ulcerative Colitis Recruiting NCT03029143 Phase 4 Vedolizumab IV
48 A Research Study to Bank Samples for Future Evaluation to Identify Biomarkers That Predispose Crohn's Disease and Ulcerative Colitis Patients to Develop Hepatosplenic T-Cell Lymphoma (HSTCL) Recruiting NCT01804166 Phase 4 Infliximab;Golimumab
49 Postmarketing Vedolizumab Milk-Only Lactation Study in Lactating Women With Active Ulcerative Colitis or Crohn's Disease Recruiting NCT02559713 Phase 4 Vedolizumab
50 Azathioprine Based on Endoscopy After Clinical Remission in Moderate to Severe Ulcerative Colitis Recruiting NCT02579733 Phase 4 Azathioprine;Placebo

Search NIH Clinical Center for Ulcerative Colitis

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Ulcerative Colitis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Ulcerative Colitis:
MultiStem
Regenerative ColoTherapy
Embryonic/Adult Cultured Cells Related to Ulcerative Colitis:
Bone marrow-derived adherent progenitor cells (MultiStem) PMIDs: 21175285
Adipose-derived mesenchymal stem cells (family)
Peripheral blood-derived hematopoietic stem cells (family)

Cochrane evidence based reviews: colitis, ulcerative

Genetic Tests for Ulcerative Colitis

Anatomical Context for Ulcerative Colitis

MalaCards organs/tissues related to Ulcerative Colitis:

39
Colon, Testes, T Cells, Liver, Neutrophil, Bone, Skin
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Ulcerative Colitis:
id Tissue Anatomical CompartmentCell Relevance
1 Bone Bone Marrow Bone Marrow Stromal Cells Potential therapeutic candidate

Publications for Ulcerative Colitis

Articles related to Ulcerative Colitis:

(show top 50) (show all 2464)
id Title Authors Year
1
Early Transcriptomic Changes in the Ileal Pouch Provide Insight into the Molecular Pathogenesis of Pouchitis and Ulcerative Colitis. ( 28221248 )
2017
2
IL23R single nucleotide polymorphisms could be either beneficial or harmful in ulcerative colitis. ( 28210080 )
2017
3
Activation of NLRP3 Inflammasome in Inflammatory Bowel Disease: Differences Between Crohn's Disease and Ulcerative Colitis. ( 28523573 )
2017
4
Gastrointestinal diseases and their oro-dental manifestations: Part 2: Ulcerative colitis. ( 28084352 )
2017
5
Efficacy of granulocyte and monocyte apheresis for antibiotic-refractory pouchitis after proctocolectomy for ulcerative colitis: an open-label, prospective, multicentre study. ( 28203278 )
2017
6
The Ileitis of Ulcerative Colitis. Why Is It Not Crohn's Disease? ( 28079623 )
2017
7
A Case of Type II Enteropathy-Associated T-Cell Lymphoma in a Patient With Ulcerative Colitis. ( 28572650 )
2017
8
Squamous cell dysplasia in the proximal rectum of three patients treated for ulcerative colitis on immunomodulators. ( 28091842 )
2017
9
Efficacy and safety of single fecal microbiota transplantation for Japanese patients with mild to moderately active ulcerative colitis. ( 27730312 )
2017
10
Oligoclonal T-cell Receptor Repertoire in Colonic Biopsies of Patients with Microscopic Colitis and Ulcerative Colitis. ( 28498152 )
2017
11
Integrated strategy of differentially expressed genes associated with ulcerative colitis. ( 28944823 )
2017
12
Improving remission rates in newly diagnosed paediatric ulcerative colitis. ( 28939375 )
2017
13
Morphological Changes in the Thymus, Composition of Its Cells, and Subpopulations of Peripheral Blood Lymphocytes during Experimental Acute Ulcerative Colitis. ( 28944427 )
2017
14
Protective role of liriodendrin in mice with dextran sulphate sodium-induced ulcerative colitis. ( 28941417 )
2017
15
Differential diagnosis in ulcerative colitis in an adolescent: Chronic granulomatous disease needs extra attention. ( 28573071 )
2017
16
Review article: dose optimisation of infliximab for acute severe ulcerative colitis. ( 28074618 )
2017
17
Effect of threatening life experiences and adverse family relations in ulcerative colitis: analysis using structural equation modeling and comparison with Crohn's disease. ( 28059861 )
2017
18
Pouchitis after ileal pouch-anal anastomosis in ulcerative colitis: Diagnosis, management, risk factors, and incidence. ( 27681447 )
2017
19
Correlation of endoscopic disease severity with pediatric ulcerative colitis activity index score in children and young adults with ulcerative colitis. ( 28566893 )
2017
20
The miR-200 family is increased in dysplastic lesions in ulcerative colitis patients. ( 28288169 )
2017
21
Intraepidermal neutrophilic dermatosis type of IgA pemphigus with circulating linear IgA disease antibodies associated with ulcerative colitis. ( 28653439 )
2017
22
Cytomegalovirus Gastric Ulcer Complicated with Pyloric Obstruction in a Patient with Ulcerative Colitis. ( 28637105 )
2017
23
Non-granulomatous myositis in a patient with ulcerative colitis who showed symptoms resembling gastrocnemius myalgia syndrome. ( 28132973 )
2017
24
Usefulness of fecal calprotectin for the early prediction of short-term outcomes of remission-induction treatments in ulcerative colitis in comparison with two-item patient-reported outcome. ( 28934315 )
2017
25
Long-interval Cytapheresis as a Novel Therapeutic Strategy Leading to Dosage Reduction and Discontinuation of Steroids in Steroid-dependent Ulcerative Colitis. ( 28924114 )
2017
26
Colonic Histological Criteria Predict Development of Pouchitis after Ileal Pouch: Anal Anastomosis for Patients with Ulcerative Colitis. ( 28662525 )
2017
27
Isothiocyanate-enriched moringa seed extract alleviates ulcerative colitis symptoms in mice. ( 28922365 )
2017
28
Palisaded Granulomatous Dermatitis Associated with Ulcerative Colitis: A Comprehensive Literature Review. ( 28168136 )
2017
29
Mucosal Healing in Ulcerative Colitis: A Comprehensive Review. ( 28078646 )
2017
30
Proteinase 3-antineutrophil cytoplasmic antibody-positive ulcerative colitis presenting with abducens neuropathy. ( 28069788 )
2017
31
Functional variant in the promoter region of IL-27 alters gene transcription and confers a risk for ulcerative colitis in northern Chinese Han. ( 28069403 )
2017
32
Garidisan: Improving the Quality of Ulcer Healing in Rats with Ulcerative Colitis. ( 28928792 )
2017
33
Early Transcriptomic Changes in the Ileal Pouch Provide Insight into the Molecular Pathogenesis of Pouchitis and Ulcerative Colitis. ( 28248733 )
2017
34
Increased cholestatic enzymes in two patients with long-term history of ulcerative colitis: consider primary biliary cholangitis not always primary sclerosing cholangitis. ( 28951510 )
2017
35
Preoperative Extraintestinal Manifestations Associated with Chronic Pouchitis in Japanese Patients with Ulcerative Colitis After Ileal Pouch-anal Anastomosis: A Retrospective Study. ( 28346273 )
2017
36
Detection of enterotoxigenic Bacteroides fragilis in patients with ulcerative colitis. ( 28924454 )
2017
37
Efficacy and Safety of Vedolizumab in Ulcerative Colitis and Crohn's Disease Patients Stratified by Age. ( 28070861 )
2017
38
Diagnosis of Cytomegalovirus Infection during Exacerbation of Ulcerative Colitis. ( 28848127 )
2017
39
Biosimilar CT-P13 in treating ulcerative colitis in the real world. ( 28927246 )
2017
40
Mesalamine Enemas for Induction of Remission in Oral Mesalamine-refractory Pediatric Ulcerative Colitis: A Prospective Cohort Study. ( 28369299 )
2017
41
Insights into the pathophysiology of ulcerative colitis: interleukin-13 modulates STAT6 and p38 MAPK activity in the colon epithelial sodium channel. ( 28083943 )
2017
42
p53 and miR-34b/c genetic variation and their impact on ulcerative colitis susceptibility. ( 28934017 )
2017
43
Systematic Review and Meta-analysis: Fecal Microbiota Transplantation for Treatment of Active Ulcerative Colitis. ( 28922255 )
2017
44
Clinical, Endoscopical and Histological Correlation and Measures of Association in Ulcerative Colitis. ( 28949435 )
2017
45
Diffuse vascular malformation of large intestine clinically and radiologically misdiagnosed as ulcerative colitis. ( 28458826 )
2017
46
Long-term Extent Change of Pediatric-Onset Ulcerative Colitis. ( 28067753 )
2017
47
Unsuspected Active Ulcerative Colitis in a Patient With Dermatomyositis: A Rare Association Detected on (18)F-FDG PET/CT During the Search for an Occult Malignancy. ( 28533643 )
2017
48
Effectiveness and Safety of Golimumab in Treating Outpatient Ulcerative Colitis: A Real-Life Prospective, Multicentre, Observational Study in Primary Inflammatory Bowel Diseases Centers. ( 28922435 )
2017
49
Development of the pediatric daily ulcerative colitis signs and symptoms scale (DUCS): qualitative research findings. ( 28946891 )
2017
50
Factors associated with early outcomes following standardised therapy in children with ulcerative colitis (PROTECT): a multicentre inception cohort study. ( 28939374 )
2017

Variations for Ulcerative Colitis

Expression for Ulcerative Colitis

LifeMap Discovery
Genes differentially expressed in tissues of Ulcerative Colitis patients vs. healthy controls: 35 (show all 12)
id Gene Description Tissue Up/Dn Fold Change (log2) P value
1 CLDN8 claudin 8 Colon - 4.72 0.000
2 LCN2 lipocalin 2 Colon + 4.60 0.000
3 REG3A regenerating islet-derived 3 alpha Colon + 4.41 0.001
4 SLC26A2 solute carrier family 26 (anion exchanger), member 2 Colon - 4.19 0.000
5 PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) Colon - 4.13 0.000
6 CXCL8 chemokine (C-X-C motif) ligand 8 Colon + 3.86 0.003
7 CXCL2 chemokine (C-X-C motif) ligand 2 Colon + 3.85 0.000
8 REG1A regenerating islet-derived 1 alpha Colon + 3.68 0.005
9 RGS3 regulator of G-protein signaling 3 Colon + 3.58 0.000
10 CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) Colon + 3.55 0.000
11 OLFM4 olfactomedin 4 Colon + 3.25 0.014
12 DEFA6 defensin, alpha 6, Paneth cell-specific Colon + 3.22 0.003
Search GEO for disease gene expression data for Ulcerative Colitis.

Pathways for Ulcerative Colitis

Pathways related to Ulcerative Colitis according to GeneCards Suite gene sharing:

(show all 40)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
14.01 CRP CTNNB1 CXCL8 IL10 IL10RA IL1B
2
Show member pathways
13.36 CXCL8 IL10 IL10RA IL1B IL2 IL23R
3
Show member pathways
13.21 CTNNB1 CXCL8 IL10 IL10RA IL1B IL2
4
Show member pathways
12.99 ATG16L1 CXCL8 IL1B MUC2 NOD2 TNF
5
Show member pathways
12.85 CXCL8 IL10 IL1B IL2 TNF
6
Show member pathways
12.85 ABCB1 CXCL8 IL10 IL1B IL2 TNF
7
Show member pathways
12.55 IL10 IL1B IL2 IL23R NOD2 TNF
8 12.54 IL10 IL1B IL2 MPO TNF
9
Show member pathways
12.25 IL10 IL10RA IL1B IRGM TNF
10 12.21 IL10 IL10RA IL1B NOD2 TNF
11
Show member pathways
12.2 IL10 IL10RA IL2 IL23R
12 12.18 CTNNB1 MLH1 MSH2 TNF
13 12.12 CTNNB1 CXCL8 IL10 IL1B TNF
14
Show member pathways
12.06 CXCL8 IL10 IL1B IL2 TNF
15 12 CXCL8 IL1B IL2 TNF
16 11.99 IL10 IL2 MPO TNF
17 11.9 IL10 IL10RA IL2 IL23R
18 11.89 CXCL8 IL10 IL1B IL23R TNF
19
Show member pathways
11.83 IL10 IL1B IL2 IL23R TNF
20
Show member pathways
11.81 CTNNB1 IL10 IL10RA IL1B IL2 IL23R
21 11.77 CXCL8 IL10 IL1B TNF
22 11.77 IL10 IL1B IL2 TNF
23
Show member pathways
11.74 CXCL8 IL2 TNF
24 11.7 CXCL8 IL10 IL1B MUC2 TNF
25 11.65 CXCL8 IL1B TNF
26
Show member pathways
11.62 CXCL8 IL1B IL2 TNF
27 11.59 CXCL8 IL1B TNF
28 11.52 IL1B IL2 TNF
29 11.47 CXCL8 IL10 IL1B TNF
30 11.46 IL10 IL1B IL2 IL23R TNF
31
Show member pathways
11.42 ABCB1 MLH1 MSH2
32
Show member pathways
11.42 IL10 IL2 TNF
33 11.35 IL10 IL1B TNF
34 11.25 MLH1 MPO MSH2
35 11.21 IL10 IL10RA IL1B TNF
36 11.2 CXCL8 IL10 IL1B IL2 TNF
37 11.05 CRP CXCL8 TNF
38 11.04 CXCL8 IL10 IL10RA IL1B TNF
39 11.03 IL10 IL1B IL2 TNF
40 10.93 IL1B MPO TNF

GO Terms for Ulcerative Colitis

Biological processes related to Ulcerative Colitis according to GeneCards Suite gene sharing:

(show all 41)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.91 CTNNB1 IL1B NOD2 TNF
2 defense response GO:0006952 9.88 CXCL8 MPO NOD2 TNF
3 defense response to bacterium GO:0042742 9.88 IL10 IRGM MPO NOD2 TNF
4 cellular response to lipopolysaccharide GO:0071222 9.86 CXCL8 IL10 IRGM TNF
5 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.85 IRGM TNF UCN
6 cellular response to organic cyclic compound GO:0071407 9.85 IL1B NOD2 TNF
7 response to lipopolysaccharide GO:0032496 9.85 IL10 IL10RA IL1B IL23R MPO
8 positive regulation of JNK cascade GO:0046330 9.84 IL1B NOD2 TNF
9 response to glucocorticoid GO:0051384 9.84 IL10 TNF UCN
10 positive regulation of T cell proliferation GO:0042102 9.83 IL1B IL2 IL23R
11 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.83 CTNNB1 IL10 IL1B TNF
12 positive regulation of protein phosphorylation GO:0001934 9.8 IL1B IL2 IRGM TNF UCN
13 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.79 MLH1 MSH2 TNF
14 positive regulation of interleukin-8 production GO:0032757 9.69 IL1B NOD2 TNF
15 maintenance of gastrointestinal epithelium GO:0030277 9.68 MUC2 NOD2
16 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.68 IL1B IL23R
17 positive regulation of chemokine biosynthetic process GO:0045080 9.67 IL1B TNF
18 negative regulation of lipid storage GO:0010888 9.66 CRP TNF
19 regulation of synapse organization GO:0050807 9.65 IL10 IL10RA
20 endothelial cell apoptotic process GO:0072577 9.65 IL10 TNF
21 regulation of establishment of endothelial barrier GO:1903140 9.64 IL1B TNF
22 nucleotide-binding oligomerization domain containing 2 signaling pathway GO:0070431 9.63 IRGM NOD2
23 negative regulation of cytokine secretion involved in immune response GO:0002740 9.62 IL10 TNF
24 somatic recombination of immunoglobulin gene segments GO:0016447 9.61 MLH1 MSH2
25 negative regulation of growth of symbiont in host GO:0044130 9.61 IL10 MPO TNF
26 positive regulation of isotype switching to IgA isotypes GO:0048298 9.6 MLH1 MSH2
27 positive regulation of fever generation GO:0031622 9.59 IL1B TNF
28 sequestering of triglyceride GO:0030730 9.58 IL1B TNF
29 receptor biosynthetic process GO:0032800 9.55 IL10 TNF
30 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.54 IL1B TNF
31 positive regulation of interleukin-17 production GO:0032740 9.54 IL2 IL23R NOD2
32 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.5 IL10 IL1B TNF
33 somatic recombination of immunoglobulin genes involved in immune response GO:0002204 9.49 MLH1 MSH2
34 positive regulation of interleukin-6 production GO:0032755 9.46 IL1B NOD2 TNF UCN
35 positive regulation of isotype switching to IgG isotypes GO:0048304 9.43 IL2 MLH1 MSH2
36 protein lipidation involved in autophagosome assembly GO:0061739 9.27 IRGM
37 positive regulation of interferon-gamma production GO:0032729 9.26 IL1B IL2 IL23R TNF
38 inflammatory response GO:0006954 9.23 CRP CXCL8 IL10 IL1B IL23R IRGM
39 positive regulation of transcription from RNA polymerase II promoter GO:0045944 10.19 CTNNB1 IL10 IL1B IL2 NOD2 TNF
40 immune response GO:0006955 10.08 CXCL8 IL10 IL1B IL2 TNF
41 positive regulation of gene expression GO:0010628 10.03 CRP CTNNB1 IL1B TNF UCN

Molecular functions related to Ulcerative Colitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 ATPase activity GO:0016887 9.46 ABCB1 MLH1 MSH2 MYO9B
2 mismatched DNA binding GO:0030983 9.26 MLH1 MSH2
3 cytokine activity GO:0005125 9.02 CXCL8 IL10 IL1B IL2 TNF
4 guanine/thymine mispair binding GO:0032137 8.96 MLH1 MSH2

Sources for Ulcerative Colitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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