MCID: UMB002
MIFTS: 44

Umbilical Hernia malady

Categories: Gastrointestinal diseases

Aliases & Classifications for Umbilical Hernia

Summaries for Umbilical Hernia

Disease Ontology : 12 A intestinal disease characterized by the protrusion by part of the intestine though an opening in the abdominal muscles.

MalaCards based summary : Umbilical Hernia, also known as hernia, umbilical, is related to smith-kingsmore syndrome and shprintzen-goldberg syndrome. An important gene associated with Umbilical Hernia is CDKN1C (Cyclin Dependent Kinase Inhibitor 1C), and among its related pathways/superpathways are Endochondral Ossification and MECP2 and Associated Rett Syndrome. The drugs Rocuronium and Nicotine have been mentioned in the context of this disorder. Affiliated tissues include small intestine, liver and kidney, and related phenotypes are cardiovascular system and muscle

Wikipedia : 71 An umbilical hernia is a health condition where the abdominal wall behind the navel is damaged. It may... more...

Related Diseases for Umbilical Hernia

Diseases related to Umbilical Hernia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 62)
id Related Disease Score Top Affiliating Genes
1 smith-kingsmore syndrome 11.6
2 shprintzen-goldberg syndrome 11.2
3 carpenter syndrome 2 11.1
4 simpson-golabi-behmel syndrome 10.9
5 3mc syndrome 2 10.9
6 tatton-brown-rahman syndrome 10.9
7 3mc syndrome 1 10.9
8 fraser syndrome 10.9
9 weaver syndrome 10.9
10 mental retardation, x-linked, syndromic, martin-probst type 10.9
11 gorlin-chaudhry-moss syndrome 10.9
12 nebulin-related early-onset distal myopathy 10.2 CDKN1C IGF2
13 ehlers-danlos/osteogenesis imperfecta syndrome 10.2 H19 IGF2
14 toxin-mediated infectious botulism 10.2 H19 IGF2
15 hall-riggs mental retardation syndrome 10.1 H19 IGF2
16 epibulbar lipodermoid-preauricular appendage-polythelia syndrome 10.1 H19 IGF2
17 ceroid lipofuscinosis, neuronal, 13, kufs type 10.1 CDKN1C IGF2
18 inclusion-cell disease 10.1 H19 IGF2
19 fetal warfarin syndrome 10.1 H19 IGF2
20 hemorrhagic fever 10.0 CDKN1C H19 IGF2
21 microcephaly, seizures, and developmental delay 10.0 CDKN1C H19
22 argininosuccinic aciduria 10.0 CDKN1C H19 IGF2
23 malignant ovarian mixed epithelial neoplasm 10.0 CDKN1C H19 IGF2
24 fanconi renotubular syndrome 2 10.0 CDKN1C H19 IGF2
25 meckel's diverticulum 10.0
26 intermixed schwannian stroma-rich ganglioneuroblastoma 10.0 CDKN1C IGF2
27 cerebral cavernous malformations-2 9.9 CDKN1C H19 IGF2
28 liver cirrhosis 9.9
29 peritonitis 9.8
30 kidney disease 9.7
31 portal hypertension 9.7
32 actinomycosis 9.7
33 uterine fibroid 9.7
34 intestinal perforation 9.7
35 polycystic kidney disease 9.7
36 endometriosis 9.7
37 urachal cyst 9.7
38 adenocarcinoma 9.6
39 malignant peritoneal mesothelioma 9.6
40 gallbladder disease 9.6
41 teratoma 9.6
42 inguinal hernia 9.6
43 duodenal obstruction 9.6
44 cholelithiasis 9.6
45 congenital diaphragmatic hernia 9.6
46 intestinal atresia 9.6
47 gastrointestinal stromal tumor 9.6
48 intracranial aneurysm 9.6
49 appendicitis 9.6
50 gastroschisis 9.6

Graphical network of the top 20 diseases related to Umbilical Hernia:



Diseases related to Umbilical Hernia

Symptoms & Phenotypes for Umbilical Hernia

MGI Mouse Phenotypes related to Umbilical Hernia:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.63 DNMT3A FRAS1 IDUA IGF2 MEGF8 MTOR
2 muscle MP:0005369 9.35 DNMT3A IDUA IGF2 MEGF8 MTOR
3 renal/urinary system MP:0005367 9.02 FRAS1 IDUA IGF2 MEGF8 MTOR

Drugs & Therapeutics for Umbilical Hernia

Drugs for Umbilical Hernia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 38)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
2
Nicotine Approved Phase 4 54-11-5 942 89594
3 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2
4 Neuromuscular Agents Phase 4
5 Neuromuscular Blocking Agents Phase 4
6 Neuromuscular Nondepolarizing Agents Phase 4
7
Ibuprofen Approved Phase 3 15687-27-1 3672
8
Bupivacaine Approved, Investigational Phase 2, Phase 3 2180-92-9, 38396-39-3 2474
9 Liver Extracts Phase 3
10 Analgesics Phase 3
11 Analgesics, Non-Narcotic Phase 3
12 Anti-Inflammatory Agents Phase 3
13 Anti-Inflammatory Agents, Non-Steroidal Phase 3
14 Antirheumatic Agents Phase 3
15 Central Nervous System Depressants Phase 3,Phase 2
16 Cyclooxygenase Inhibitors Phase 3
17 Narcotics Phase 3
18 Anesthetics Phase 2, Phase 3
19 Anesthetics, Local Phase 2, Phase 3
20 Omega 3 Fatty Acid Nutraceutical Phase 3
21
Ropivacaine Approved 84057-95-4 71273 175805
22
Morphine Approved, Investigational 57-27-2 5288826
23
Acetaminophen Approved 103-90-2 1983
24
Chloroprocaine Approved 133-16-4 8612
25
Prilocaine Approved 721-50-6 4906
26
Procaine Approved, Investigational, Vet_approved 59-46-1 4914
27
Sufentanil Approved, Investigational 56030-54-7 41693
28
Menthol Approved 2216-51-5 16666
29
Chlorhexidine Approved, Vet_approved 55-56-1 9552079 2713
30 Coagulants
31 Fibrin Tissue Adhesive
32 Hemostatics
33 Antipyretics
34 Adjuvants, Anesthesia
35 Analgesics, Opioid
36 Anesthetics, General
37 Anesthetics, Intravenous
38 Chlorhexidine gluconate

Interventional clinical trials:

(show top 50) (show all 58)
id Name Status NCT ID Phase
1 Optimizing Surgical Conditions During Laparoscopic Umbilical, Incisional -and Linea Alba Herniotomy With Deep Neuromuscular Blockade Completed NCT02247466 Phase 4
2 Incisional Hernia Outcomes Study Using Parietex Composite Mesh Terminated NCT00459602 Phase 4
3 Conservative Treatment Versus Elective Repair of Umbilical Hernia in Patients With Ascites and Liver Cirrhosis Unknown status NCT01421550 Phase 3
4 Does Preoperative Caldolor Decrease the Requirement for Postoperative Narcotics Unknown status NCT01297829 Phase 3
5 North American Study for the Treatment of Refractory Ascites (NASTRA) Completed NCT00006166 Phase 3
6 Prevention of Umbilical Port-site Hernia After Laparoscopic Cholecystectomy Using a Prosthetic Mesh Versus Simple Suture Completed NCT01802229 Phase 3
7 Single Incision Laparoscopic Surgery vs Flexible Single Incision Surgery for Cholecystectomy Completed NCT01558414 Phase 3
8 Comparative Study Matching Intraperitoneal Onlay Mesh (IPOM) and Sublay Mesh to Treat Umbilical Hernia Recruiting NCT01201564 Phase 3
9 Caudal Versus Rectus Sheath Study Terminated NCT01394523 Phase 2, Phase 3
10 Does a Transabdominal Plane Block Decrease Patient Pain After Ventral Hernia Repair? Unknown status NCT02007096 Phase 2
11 "BP as a New Device for Surgery and Solid Cancer and Hematopoietic System Tumors Treatment. Effects of BP Implantation" Unknown status NCT02328352 Phase 1, Phase 2
12 Assess the Feasibility and Efficacy of the CollaRx® Bupivacaine Implant in Men After Laparoscopic Inguinal or Umbilical Herniorrhaphy Completed NCT01224145 Phase 2
13 A Comparative Study on Trans-umbilical Single-port Laparoscopic Extra-peritoneal Approach Versus Conventional Repair for Inguinal Hernia in Children Recruiting NCT02960529 Phase 2
14 Laparoscopic or Conventional Mesh Repair of Incisional and Umbilical Hernia Unknown status NCT00970515
15 Postoperative Pain After Pediatric Umbilical Hernia Repair Unknown status NCT01015053
16 The Flemish Umbilical Nitinol Mesh Trial, a Multicenter Trial Unknown status NCT01543789
17 Intraperitoneal Mesh With 3cm Overlap Versus a Rives-Stoppa Repair With a 6cm Overlap in Hernia Umbilicalis Unknown status NCT00323141
18 The Impact of Medical Clowning on Pain and Stress Level in Pediatric Patients Undergoing Hernia Repair Surgery LAUGH Study. Unknown status NCT01622218
19 Case-control Study of Mesh-infection After a Size Tailored Hernia Repair With C-Qur V-Patch Unknown status NCT01761708
20 Primary and Secondary Ventral Hernia Repair Using Long-term Resorbable Versus Non-resorbable Large Pore Synthetic Mesh. Unknown status NCT01622725
21 Long Term Complaints After Elective Repair for Small Umbilical or Epigastric Hernias Unknown status NCT01501682
22 A Prospective Study Comparing Telescopic vs. Balloon Dissection in Single Incision Laparoscopic Inguinal Herniorraphy (SILTELESCOPIC) Unknown status NCT01883115
23 TEP Versus Open Minimal Suture Repair for the Sportsman's Groin Unknown status NCT02297711
24 Effect of Reoperation for Recurrence After Open Umbilical Hernia Repair Completed NCT01607801
25 Analgesic Efficacy After Umbilical Hernia Repair in Children Completed NCT00578136
26 Mesh Versus Suture Repair for Umbilical Hernias Completed NCT00789230
27 Percutaneous Rectus Sheath Block Versus Intra-operative Rectus Sheath Block for Pediatric Umbilical Hernia Repair Completed NCT02341144
28 Ultrasound-guided Rectus Sheath Block for Post-operative Pain Control Following Umbilical Hernia Repair Completed NCT00836134
29 Risk Factors for Poor Outcome After Epigastric and Umbilical Hernia Repair Completed NCT01665859
30 Chronic Complaints After Small Umbilical Hernia Repair Completed NCT01741740
31 Self-Expanding Multi-Layered Partially Resorbable Lightweight Polypropylene Mesh Device (Proceed Ventral Patch® Or Pvp®) For The Treatment of Small and Medium Umbilical Ventral Hernias Completed NCT01307696
32 Prospective Evaluation of the Proceed Ventral Patch With and Without Laparoscopic Evaluation Completed NCT01183325
33 The Effect of Sutures Versus Mesh in Umbilical Hernia Repair Completed NCT01635868
34 Mesh Fixation With Intraperitoneal Tisseel Completed NCT00842842
35 Watchful Waiting of Incisional Hernias Completed NCT00351455
36 Quality of Life After Laparoscopic Inguinal- Incisional and Umbilical Herniotomy. Completed NCT01289093
37 Risk of Umbilical Trocar-site Hernia After SILC Cholecystectomy Versus Conventional Cholecystectomy Completed NCT01740973
38 A Trial Comparing Combination Therapy of Acetaminophen Plus Ibuprofen Versus Tylenol #3 for the Treatment of Pain After Outpatient Surgery Completed NCT00245375
39 Spinal Anesthesia for Outpatient Abdominal Wall Surgery: Comparison of Bupivacaine, 2-chloroprocaine and Prilocaine Completed NCT02813382
40 Laparoscopic Hernia Repair With Lateral Umbilicus Ligament for Children Completed NCT01377181
41 a New Way for Laparoscopic Inguinal Hernia Repair in Pediatric Completed NCT01380067
42 Does Pregnancy Increase Risk of Ventral Hernia Recurrence? Completed NCT02564757
43 A Prospective Study Comparing Single and Multiport Laparoscopic Inguinal Hernia Repair Completed NCT01660048
44 Pregnancy Subsequent to Ventral Hernia Repair Completed NCT02398565
45 A Retrospective Study With Prospective Follow-Up of Laparoscopic Ventral Hernia Repair Utilizing the Bard Sepramesh IP Composite Completed NCT01305473
46 Robotic Utility for Surgical Treatment of Umbilical Hernias Recruiting NCT02975414
47 Natural Orifice Translumenal Endoscopic Surgery (NOTES): Laparoscopic Assisted Transvaginal Ventral Hernia Repair Recruiting NCT01398215
48 Trans-incisional vs Laparoscopic Guided Rectus Sheath Block for Pediatric Single Incision Laparoscopic Cholecystectomy Recruiting NCT02494336
49 Initiation of Resuscitation While Attached to the Cord With Congenital Diaphragmatic Hernia Recruiting NCT03094039
50 Comparison of Different Meshes in Laparoscopic Hernia Repair Recruiting NCT02712827

Search NIH Clinical Center for Umbilical Hernia

Cochrane evidence based reviews: hernia, umbilical

Genetic Tests for Umbilical Hernia

Genetic tests related to Umbilical Hernia:

id Genetic test Affiliating Genes
1 Umbilical Hernia 29

Anatomical Context for Umbilical Hernia

MalaCards organs/tissues related to Umbilical Hernia:

39
Small Intestine, Liver, Kidney, Appendix

Publications for Umbilical Hernia

Articles related to Umbilical Hernia:

(show top 50) (show all 69)
id Title Authors Year
1
Umbilical hernia following gastroschisis closure: a common event? ( 27344584 )
2016
2
A genome-wide association study of copy number variations with umbilical hernia in swine. ( 27028052 )
2016
3
Umbilical hernia masking primary umbilical endometriosis - a case report. ( 27833977 )
2016
4
Intestinal blood flow assessment by indocyanine green fluorescence imaging in a patient with the incarcerated umbilical hernia: Report of a case. ( 27257484 )
2016
5
A multi-institutional, propensity-score-matched comparison of post-operative outcomes between general anesthesia and monitored anesthesia care with intravenous sedation in umbilical hernia repair. ( 26860730 )
2016
6
A complication to remember: stitch sinus following laparoscopic umbilical hernia repair. ( 27572679 )
2016
7
Severe Hydronephrosis and Perinephric Urinoma with Rupture of Renal Fornix Secondary to Postoperative Urinary Retention following Laparoscopic Umbilical Hernia Repair. ( 27555977 )
2016
8
Mucinous cystadenoma of the appendix presenting as an umbilical hernia: A case report. ( 27313766 )
2016
9
Elective Surgery of Umbilical Hernia as a First Clinical Manifestation of a Gastrointestinal Stromal Tumor (Gist) - Case Report. ( 27648625 )
2016
10
The Hernia-Neck-Ratio (HNR), a Novel Predictive Factor for Complications of Umbilical Hernia. ( 27194561 )
2016
11
Umbilical hernia in patients with liver cirrhosis: A surgical challenge. ( 27462389 )
2016
12
Primary peritoneal adenocarcinoma as content of an incarcerated umbilical hernia: A case-report and review of the literature. ( 26748210 )
2016
13
Association of umbilical hernia with volume of ascites in liver cirrhosis: A retrospective observational study. ( 27792277 )
2016
14
Spontaneous endometriosis associated with an umbilical hernia: A case report and review of the literature. ( 27898348 )
2016
15
Intestinal Perforation in Obstructed Umbilical Hernia due to Wedged Plum Seed. ( 27398326 )
2016
16
Reappraisal of adhesive strapping as treatment for infantile umbilical hernia. ( 26624557 )
2016
17
Surgical outcome of mesh and suture repair in primary umbilical hernia: postoperative complications and recurrence. ( 26879081 )
2016
18
Primary Hydatid Cyst of Umbilicus, Mimicking an Umbilical Hernia. ( 27190669 )
2016
19
Proposed technique for open repair of a small umbilical hernia and rectus divarication with self-gripping mesh. ( 26886012 )
2016
20
A case of incarcerated umbilical hernia in an adult treated by laparoscopic surgery. ( 25672973 )
2015
21
Umbilical hernia in a patient with cirrhosis. ( 26185937 )
2015
22
Topic: Abdominal Wall Hernia - Umbilical hernia: choice of approach, repair, results, follow up. ( 26518839 )
2015
23
A rare case of abdominal cocoon presenting as umbilical hernia. ( 25963367 )
2015
24
Double half-cone flap umbilicoplasty for proboscoid umbilical hernia in a 2 years old child with satisfactory results 2 years later. ( 26664545 )
2015
25
Umbilical hernia with cholelithiasis and hiatal hernia: a clinical entity similar to Saint's triad. ( 26366362 )
2015
26
Umbilical paracentesis for incarcerated umbilical hernia in patients with end-stage liver disease. ( 26306472 )
2015
27
Topic: Abdominal Wall Hernia - Umbilical hernia: choice of approach, repair, results, follow up. ( 26518805 )
2015
28
Current options in umbilical hernia repair in adult patients. ( 26504420 )
2015
29
Laparoscopic versus open repair of para-umbilical hernia. Is it a good alternative? ( 26228333 )
2015
30
Incarceration of umbilical hernia: a rare complication of large volume paracentesis. ( 26629305 )
2015
31
A case of a strangulated umbilical hernia causing gangrenous appendicitis. ( 26439483 )
2015
32
Spread patterns and effectiveness for surgery after ultrasound-guided rectus sheath block in adult day-case patients scheduled for umbilical hernia repair. ( 26330714 )
2015
33
Catamenial Pain in Umbilical Hernia with Spontaneous Reduction: An Unusual Presentation of a Rare Entity. ( 26436005 )
2015
34
SUSCEPTIBILITY LOCI FOR UMBILICAL HERNIA IN SWINE DETECTED BY GENOME-WIDE ASSOCIATION. ( 27169231 )
2015
35
Recurrent major umbilical bleeding caused by omental varices in two patients with umbilical hernia and portal hypertension. ( 26245284 )
2015
36
An extremely rare complication of Meckel's diverticulum: enterocutaneous fistulization of umbilical hernia. ( 26176259 )
2015
37
Concomitant abdominoplasty and umbilical hernia repair using the Ventralex hernia patch. ( 25811568 )
2015
38
The repair of umbilical hernia in cirrhotic patients: 18 consecutive case series in a single institute. ( 26236698 )
2015
39
Umbilical Hernia Repair: Analysis After 934 Procedures. ( 26350669 )
2015
40
An atypical lateral hernia and concomitant inguinal and umbilical hernias in a patient with polycystic kidney disease and an intracranial aneurysm - a combined approach of clinical and radiological investigation, endoscopic hernia repair, and anatomical cadaver model documentation and a systematic review of the literature. ( 25763300 )
2015
41
MANAGEMENT OF OMPHALOPHLEBITIS AND UMBILICAL HERNIA IN THREE NEONATAL GIRAFFE (GIRAFFA CAMELOPARDALIS). ( 26667556 )
2015
42
Umbilical Hernia in Peritoneal Dialysis Patients: Surgical Treatment and Risk Factors. ( 26197840 )
2015
43
Shprintzen-Goldberg syndrome presenting as umbilical hernia in an Indian child. ( 24611072 )
2014
44
Umbilical hernia in autosomal dominant polycystic kidney disease. ( 24408221 )
2014
45
Incarcerated Umbilical Hernia of Unexpected Origin: A Primitive Neuroectodermal Tumor With Early Recurrence. ( 24395853 )
2014
46
The strangulated umbilical hernia of Queen Caroline. ( 26012198 )
2014
47
Deceased donor liver transplantation performed one week after small bowel resection for complicated umbilical hernia: a case report. ( 26155258 )
2014
48
Prognosis elements in surgical treatment of complicated umbilical hernia in patients with liver cirrhosis. ( 24155783 )
2013
49
Outcome of sublay mesh repair in non-complicated umbilical hernia with liver cirrhosis and ascites. ( 24378913 )
2013
50
Malignant peritoneal mesothelioma presenting umbilical hernia and Sister Mary Joseph's nodule. ( 23951397 )
2013

Variations for Umbilical Hernia

Expression for Umbilical Hernia

Search GEO for disease gene expression data for Umbilical Hernia.

Pathways for Umbilical Hernia

Pathways related to Umbilical Hernia according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.97 CDKN1C IGF2
2 10.75 IGF2 MTOR
3
Show member pathways
10.04 IGF2 MTOR

GO Terms for Umbilical Hernia

Biological processes related to Umbilical Hernia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 embryonic limb morphogenesis GO:0030326 9.32 FRAS1 MEGF8
2 cellular response to amino acid stimulus GO:0071230 9.26 DNMT3A MTOR
3 positive regulation of cell death GO:0010942 9.16 DNMT3A MTOR
4 response to cocaine GO:0042220 8.96 DNMT3A MTOR
5 regulation of gene expression by genetic imprinting GO:0006349 8.62 DNMT3A IGF2

Sources for Umbilical Hernia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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