MCID: UMB002
MIFTS: 43

Umbilical Hernia

Categories: Gastrointestinal diseases

Aliases & Classifications for Umbilical Hernia

Summaries for Umbilical Hernia

Disease Ontology : 12 A intestinal disease characterized by the protrusion by part of the intestine though an opening in the abdominal muscles.

MalaCards based summary : Umbilical Hernia, also known as hernia, umbilical, is related to smith-kingsmore syndrome and shprintzen-goldberg craniosynostosis syndrome. An important gene associated with Umbilical Hernia is CDKN1C (Cyclin Dependent Kinase Inhibitor 1C), and among its related pathways/superpathways are Endochondral Ossification and MECP2 and Associated Rett Syndrome. The drugs Ibuprofen and Bupivacaine have been mentioned in the context of this disorder. Affiliated tissues include small intestine, liver and kidney, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 72 An umbilical hernia is a health condition where the abdominal wall behind the navel is damaged. It may... more...

Related Diseases for Umbilical Hernia

Diseases related to Umbilical Hernia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 73)
# Related Disease Score Top Affiliating Genes
1 smith-kingsmore syndrome 11.8
2 shprintzen-goldberg craniosynostosis syndrome 11.3
3 gorlin-chaudhry-moss syndrome 11.1
4 carpenter syndrome 2 11.1
5 hypothyroidism, congenital, nongoitrous, 2 11.0
6 fraser syndrome 1 11.0
7 gapo syndrome 11.0
8 3mc syndrome 3 11.0
9 3mc syndrome 1 11.0
10 3mc syndrome 2 11.0
11 weaver syndrome 11.0
12 mental retardation, x-linked, syndromic, martin-probst type 11.0
13 achondrogenesis, type ib 11.0
14 chromosome 6q11-q14 deletion syndrome 11.0
15 tatton-brown-rahman syndrome 11.0
16 cohen-gibson syndrome 11.0
17 simpson-golabi-behmel syndrome 11.0
18 bamforth syndrome 11.0
19 central congenital hypothyroidism 11.0
20 peripheral resistance to thyroid hormones 11.0
21 silver-russell syndrome due to a point mutation 10.2 CDKN1C IGF2
22 silver-russell syndrome due to an imprinting defect of 11p15 10.2 H19 IGF2
23 silver-russell syndrome due to 11p15 microduplication 10.2 H19 IGF2
24 beckwith-wiedemann syndrome due to imprinting defect of 11p15 10.2 H19 IGF2
25 hereditary wilms' tumor 10.1 CDKN1C IGF2
26 hydatidiform mole, recurrent, 1 10.0 CDKN1C H19
27 mucopolysaccharidosis, type vii 10.0 IDUA IGF2
28 liver cirrhosis 10.0
29 hemihyperplasia, isolated 10.0 CDKN1C H19 IGF2
30 fetal macrosomia 9.9 H19 IGF2
31 wilms tumor 5 9.9 CDKN1C H19 IGF2
32 endometriosis 9.9
33 peritonitis 9.9
34 silver-russell syndrome 9.9 CDKN1C H19 IGF2
35 hepatoblastoma 9.9 CDKN1C H19 IGF2
36 beckwith-wiedemann syndrome 9.9 CDKN1C H19 IGF2
37 episodic pain syndrome, familial, 1 9.8
38 portal hypertension 9.8
39 intestinal perforation 9.8
40 kidney disease 9.8
41 actinomycosis 9.8
42 polycystic kidney disease 9.8
43 urachal cyst 9.8
44 adrenocortical carcinoma, hereditary 9.8 CDKN1C IGF2
45 spastic paraplegia 17, autosomal dominant 9.8 CDKN1C GNAS-AS1 IGF2
46 hernia, hiatus 9.7
47 gastroschisis 9.7
48 galactosialidosis 9.7
49 pancreatic cancer 9.7
50 gastrointestinal stromal tumor 9.7

Graphical network of the top 20 diseases related to Umbilical Hernia:



Diseases related to Umbilical Hernia

Symptoms & Phenotypes for Umbilical Hernia

GenomeRNAi Phenotypes related to Umbilical Hernia according to GeneCards Suite gene sharing:

25 (show all 16)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.6 MTOR
2 Increased shRNA abundance (Z-score > 2) GR00366-A-107 9.6 ELMO2
3 Increased shRNA abundance (Z-score > 2) GR00366-A-11 9.6 ELMO2 MTOR
4 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.6 ELMO2
5 Increased shRNA abundance (Z-score > 2) GR00366-A-143 9.6 ELMO2
6 Increased shRNA abundance (Z-score > 2) GR00366-A-16 9.6 CDKN1C ELMO2 MTOR
7 Increased shRNA abundance (Z-score > 2) GR00366-A-205 9.6 CDKN1C
8 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.6 MTOR
9 Increased shRNA abundance (Z-score > 2) GR00366-A-51 9.6 CDKN1C
10 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.6 CDKN1C
11 Increased shRNA abundance (Z-score > 2) GR00366-A-56 9.6 CDKN1C
12 Increased shRNA abundance (Z-score > 2) GR00366-A-57 9.6 CDKN1C
13 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.6 MTOR
14 Increased shRNA abundance (Z-score > 2) GR00366-A-76 9.6 ELMO2
15 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.6 MTOR
16 Increased shRNA abundance (Z-score > 2) GR00366-A-93 9.6 ELMO2

MGI Mouse Phenotypes related to Umbilical Hernia:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 muscle MP:0005369 9.02 DNMT3A IDUA IGF2 MEGF8 MTOR

Drugs & Therapeutics for Umbilical Hernia

Drugs for Umbilical Hernia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ibuprofen Approved Phase 3 15687-27-1 3672
2
Bupivacaine Approved, Investigational Phase 2, Phase 3 38396-39-3, 2180-92-9 2474
3 Analgesics Phase 3
4 Central Nervous System Depressants Phase 3,Phase 2
5 Narcotics Phase 3
6 Cyclooxygenase Inhibitors Phase 3
7 Analgesics, Non-Narcotic Phase 3
8 Peripheral Nervous System Agents Phase 3,Phase 2
9 Anti-Inflammatory Agents Phase 3
10 Anti-Inflammatory Agents, Non-Steroidal Phase 3
11 Liver Extracts Phase 3
12 Antirheumatic Agents Phase 3
13 Anesthetics Phase 2, Phase 3
14 Anesthetics, Local Phase 2, Phase 3
15
Morphine Approved, Investigational 57-27-2 5288826
16
Acetaminophen Approved 103-90-2 1983
17
Ropivacaine Approved 84057-95-4 175805 71273
18
Menthol Approved 2216-51-5 16666
19 Fibrin Tissue Adhesive
20 Coagulants
21 Hemostatics
22 Antipyretics
23 Anesthetics, General

Interventional clinical trials:

(show all 39)

# Name Status NCT ID Phase Drugs
1 Conservative Treatment Versus Elective Repair of Umbilical Hernia in Patients With Ascites and Liver Cirrhosis Unknown status NCT01421550 Phase 3
2 Does Preoperative Caldolor Decrease the Requirement for Postoperative Narcotics Unknown status NCT01297829 Phase 3 Intravenous Ibuprofen
3 North American Study for the Treatment of Refractory Ascites (NASTRA) Completed NCT00006166 Phase 3
4 Comparative Study Matching Intraperitoneal Onlay Mesh (IPOM) and Sublay Mesh to Treat Umbilical Hernia Recruiting NCT01201564 Phase 3
5 Caudal Versus Rectus Sheath Study Terminated NCT01394523 Phase 2, Phase 3 Bupivacaine
6 Does a Transabdominal Plane Block Decrease Patient Pain After Ventral Hernia Repair? Completed NCT02007096 Phase 2 Transabdominal Plane Block;Non Transabdominal Plane Block
7 Laparoscopic or Conventional Mesh Repair of Incisional and Umbilical Hernia Unknown status NCT00970515
8 The Flemish Umbilical Nitinol Mesh Trial, a Multicenter Trial Unknown status NCT01543789
9 The Impact of Medical Clowning on Pain and Stress Level in Pediatric Patients Undergoing Hernia Repair Surgery LAUGH Study. Unknown status NCT01622218
10 Case-control Study of Mesh-infection After a Size Tailored Hernia Repair With C-Qur V-Patch Unknown status NCT01761708
11 Primary and Secondary Ventral Hernia Repair Using Long-term Resorbable Versus Non-resorbable Large Pore Synthetic Mesh. Unknown status NCT01622725
12 Effect of Reoperation for Recurrence After Open Umbilical Hernia Repair Completed NCT01607801
13 Analgesic Efficacy After Umbilical Hernia Repair in Children Completed NCT00578136 Bupivacaine
14 Mesh Versus Suture Repair for Umbilical Hernias Completed NCT00789230
15 Percutaneous Rectus Sheath Block Versus Intra-operative Rectus Sheath Block for Pediatric Umbilical Hernia Repair Completed NCT02341144 Ropivacaine
16 Ultrasound-guided Rectus Sheath Block for Post-operative Pain Control Following Umbilical Hernia Repair Completed NCT00836134
17 Risk Factors for Poor Outcome After Epigastric and Umbilical Hernia Repair Completed NCT01665859
18 Postoperative Pain After Pediatric Umbilical Hernia Repair Completed NCT01015053
19 Chronic Complaints After Small Umbilical Hernia Repair Completed NCT01741740
20 Self-Expanding Multi-Layered Partially Resorbable Lightweight Polypropylene Mesh Device (Proceed Ventral Patch® Or Pvp®) For The Treatment of Small and Medium Umbilical Ventral Hernias Completed NCT01307696
21 The Effect of Sutures Versus Mesh in Umbilical Hernia Repair Completed NCT01635868
22 Mesh Fixation With Intraperitoneal Tisseel Completed NCT00842842
23 Prospective Evaluation of the Proceed Ventral Patch With and Without Laparoscopic Evaluation Completed NCT01183325
24 Risk of Umbilical Trocar-site Hernia After SILC Cholecystectomy Versus Conventional Cholecystectomy Completed NCT01740973
25 Watchful Waiting of Incisional Hernias Completed NCT00351455
26 Quality of Life After Laparoscopic Inguinal- Incisional and Umbilical Herniotomy. Completed NCT01289093
27 A Trial Comparing Combination Therapy of Acetaminophen Plus Ibuprofen Versus Tylenol #3 for the Treatment of Pain After Outpatient Surgery Completed NCT00245375 Tylenol #3;Combination Tylenol and Ibuprofen
28 A Retrospective Study With Prospective Follow-Up of Laparoscopic Ventral Hernia Repair Utilizing the Bard Sepramesh IP Composite Completed NCT01305473
29 Comparison of Ultrasound-guided Transversus Abdominis Plane Block (TAPB)Versus Rectus Sheath Block (RSB) Recruiting NCT03074240
30 Natural Orifice Translumenal Endoscopic Surgery (NOTES): Laparoscopic Assisted Transvaginal Ventral Hernia Repair Recruiting NCT01398215
31 Open Preperitoneal Mesh Versus Retromuscular Mesh Versus Suture Repair for Abdominal Wall Hernias Recruiting NCT03255239
32 Trans-incisional vs Laparoscopic Guided Rectus Sheath Block for Pediatric Single Incision Laparoscopic Cholecystectomy Recruiting NCT02494336 Ropivacaine
33 Visible vs. Non-Visible Mesh in Underlay Positon After Repair of Umbilical Hernias Active, not recruiting NCT03200405
34 Robotic Utility for Surgical Treatment of Umbilical Hernias Active, not recruiting NCT02975414
35 A Cross-specialty Collaboration Platform for Mucopolysaccharidosis Confirmative Diagnosis Not yet recruiting NCT03017677
36 No Need for Neuromuscular Blockade in Daycase Laparoscopic Surgery Not yet recruiting NCT02782832
37 Minimally Invasive Closure of Umbilical Hernias Terminated NCT00706329
38 Mucopolysaccharidosis (MPS) I, II, and VI Screening in a High-Risk Population With Previous Surgical Repair or Presence of Inguinal and/or Umbilical Hernia in Combination With Pediatric ENT Surgery (The HATT Project) Terminated NCT02095015
39 Prospective Study Of A Size Tailored Approach To Repair Umbilical And Epigastric Primary Ventral Hernias Terminated NCT01639118

Search NIH Clinical Center for Umbilical Hernia

Cochrane evidence based reviews: hernia, umbilical

Genetic Tests for Umbilical Hernia

Genetic tests related to Umbilical Hernia:

# Genetic test Affiliating Genes
1 Umbilical Hernia 28

Anatomical Context for Umbilical Hernia

MalaCards organs/tissues related to Umbilical Hernia:

38
Small Intestine, Liver, Kidney, Appendix

Publications for Umbilical Hernia

Articles related to Umbilical Hernia:

(show top 50) (show all 95)
# Title Authors Year
1
Variceal hemorrhage with white nipple sign associated with strangulated umbilical hernia in a patient with cirrhosis. ( 29425783 )
2018
2
Importance of mesh overlap on hernia recurrence after open umbilical hernia repair with bilayer prosthesis. ( 29429547 )
2018
3
Umbilical Hernia. ( 28586889 )
2017
4
Laparoscopic transabdominal preperitoneal approach for umbilical hernia with rectus diastasis. ( 28727317 )
2017
5
Simultaneous Abdominoplasty and Umbilical Hernia Repair via Laparoscopy: a Preliminary Report. ( 28704183 )
2017
6
Postoperative Pain After Laparoscopic Repair of Primary Umbilical Hernia: Titanium Tacks Versus Absorbable Tacks: A Prospective Comparative Cohort Analysis of 80 Patients With a Long-term Follow-up. ( 28915205 )
2017
7
Factors Associated With Long-term Outcomes of Umbilical Hernia Repair. ( 28122076 )
2017
8
Rupture of Umbilical Hernia with Evisceration in a Newborn - A Case Report. ( 28920027 )
2017
9
The feasibility of local anesthesia for the surgical treatment of umbilical hernia: a systematic review of the literature. ( 28108822 )
2017
10
Umbilical hernia repair in pregnant patients: review of the American College of Surgeons National Surgical Quality Improvement Program. ( 28735364 )
2017
11
Mesh Versus Patch Repair for Epigastric and Umbilical Hernia (MORPHEUS Trial); One-Year Results of a Randomized Controlled Trial. ( 29026977 )
2017
12
Spontaneous Endometriosis Within a Primary Umbilical Hernia. ( 29164008 )
2017
13
Simultaneous Umbilical Hernia Repair with Transumbilical Ventriculoperitoneal Shunt Placement. ( 28208152 )
2017
14
Surprising Twist in the Plot - Sister Mary Joseph's Nodule of Pancreatic Cancer Mimicking Wound Infection after Umbilical Hernia Repair. ( 28589449 )
2017
15
Percutaneous ultrasound-guided vs. intraoperative rectus sheath block for pediatric umbilical hernia repair: A randomized clinical trial. ( 28377023 )
2017
16
Laparoscopic versus Open Repair of Para-Umbilical Hernia- A Prospective Comparative Study of Short Term Outcomes. ( 28969195 )
2017
17
Spontaneous evisceration of umbilical hernia in a patient with congenital nephrotic syndrome. ( 28507377 )
2017
18
Complexity of the "Simple" Umbilical Hernia Repair. ( 28122080 )
2017
19
Long-term follow-up results of umbilical hernia repair. ( 29362649 )
2017
20
Umbilical appearance and patient/parent satisfaction over 5years of follow-up after umbilical hernia repair in children. ( 28629819 )
2017
21
Unusual clinical umbilical hernia: pitfall. ( 28381548 )
2017
22
Incarceration of a pedunculated uterine fibroid in an umbilical hernia. ( 28534020 )
2017
23
Flood Syndrome: Spontaneous Umbilical Hernia Rupture Leaking Ascitic Fluid-A Case Report. ( 28678688 )
2017
24
A new approach to umbilical hernia repair: the Circular suture technique for defects less than 2 cm. ( 28892467 )
2017
25
The Evaluation of the Therapeutic Outcomes of Umbilical Hernia. ( 28833971 )
2017
26
Primary Hydatid Cyst of Umbilicus, Mimicking an Umbilical Hernia. ( 27190669 )
2016
27
Intestinal Perforation in Obstructed Umbilical Hernia due to Wedged Plum Seed. ( 27398326 )
2016
28
Elective Surgery of Umbilical Hernia as a First Clinical Manifestation of a Gastrointestinal Stromal Tumor (Gist) - Case Report. ( 27648625 )
2016
29
Proposed technique for open repair of a small umbilical hernia and rectus divarication with self-gripping mesh. ( 26886012 )
2016
30
Umbilical hernia masking primary umbilical endometriosis - a case report. ( 27833977 )
2016
31
Umbilical hernia following gastroschisis closure: a common event? ( 27344584 )
2016
32
Surgical outcome of mesh and suture repair in primary umbilical hernia: postoperative complications and recurrence. ( 26879081 )
2016
33
A multi-institutional, propensity-score-matched comparison of post-operative outcomes between general anesthesia and monitored anesthesia care with intravenous sedation in umbilical hernia repair. ( 26860730 )
2016
34
A complication to remember: stitch sinus following laparoscopic umbilical hernia repair. ( 27572679 )
2016
35
Mucinous cystadenoma of the appendix presenting as an umbilical hernia: A case report. ( 27313766 )
2016
36
Reappraisal of adhesive strapping as treatment for infantile umbilical hernia. ( 26624557 )
2016
37
Spontaneous endometriosis associated with an umbilical hernia: A case report and review of the literature. ( 27898348 )
2016
38
Umbilical hernia in patients with liver cirrhosis: A surgical challenge. ( 27462389 )
2016
39
A genome-wide association study of copy number variations with umbilical hernia in swine. ( 27028052 )
2016
40
The Hernia-Neck-Ratio (HNR), a Novel Predictive Factor for Complications of Umbilical Hernia. ( 27194561 )
2016
41
Primary peritoneal adenocarcinoma as content of an incarcerated umbilical hernia: A case-report and review of the literature. ( 26748210 )
2016
42
Intestinal blood flow assessment by indocyanine green fluorescence imaging in a patient with the incarcerated umbilical hernia: Report of a case. ( 27257484 )
2016
43
Severe Hydronephrosis and Perinephric Urinoma with Rupture of Renal Fornix Secondary to Postoperative Urinary Retention following Laparoscopic Umbilical Hernia Repair. ( 27555977 )
2016
44
Association of umbilical hernia with volume of ascites in liver cirrhosis: A retrospective observational study. ( 27792277 )
2016
45
Umbilical Hernia Repair: Analysis After 934 Procedures. ( 26350669 )
2015
46
Spread patterns and effectiveness for surgery after ultrasound-guided rectus sheath block in adult day-case patients scheduled for umbilical hernia repair. ( 26330714 )
2015
47
Topic: Abdominal Wall Hernia - Umbilical hernia: choice of approach, repair, results, follow up. ( 26518805 )
2015
48
Double half-cone flap umbilicoplasty for proboscoid umbilical hernia in a 2 years old child with satisfactory results 2 years later. ( 26664545 )
2015
49
An atypical lateral hernia and concomitant inguinal and umbilical hernias in a patient with polycystic kidney disease and an intracranial aneurysm - a combined approach of clinical and radiological investigation, endoscopic hernia repair, and anatomical cadaver model documentation and a systematic review of the literature. ( 25763300 )
2015
50
Umbilical hernia with cholelithiasis and hiatal hernia: a clinical entity similar to Saint's triad. ( 26366362 )
2015

Variations for Umbilical Hernia

Expression for Umbilical Hernia

Search GEO for disease gene expression data for Umbilical Hernia.

Pathways for Umbilical Hernia

Pathways related to Umbilical Hernia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.97 CDKN1C IGF2
2 10.75 IGF2 MTOR
3
Show member pathways
10.04 IGF2 MTOR

GO Terms for Umbilical Hernia

Biological processes related to Umbilical Hernia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular response to amino acid stimulus GO:0071230 9.26 DNMT3A MTOR
2 positive regulation of cell death GO:0010942 9.16 DNMT3A MTOR
3 response to cocaine GO:0042220 8.96 DNMT3A MTOR
4 regulation of gene expression by genetic imprinting GO:0006349 8.62 DNMT3A IGF2

Sources for Umbilical Hernia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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