MCID: UND007
MIFTS: 28

Undifferentiated Connective Tissue Disease

Categories: Rare diseases, Bone diseases

Aliases & Classifications for Undifferentiated Connective Tissue Disease

MalaCards integrated aliases for Undifferentiated Connective Tissue Disease:

Name: Undifferentiated Connective Tissue Disease 49 69
Undifferentiated Connective Tissue Syndrome 49 55
Uctd 49 55

Classifications:



External Ids:

Orphanet 55 ORPHA90002
UMLS via Orphanet 70 C0409999
ICD10 via Orphanet 33 M35.8
UMLS 69 C0409999

Summaries for Undifferentiated Connective Tissue Disease

NIH Rare Diseases : 49 Undifferentiated connective tissue disease is a condition that affects the joints and muscles of the body. A disorder is classified as undifferentiated connective tissue disease when it cannot be classified as another type of connective tissue disease, such as rheumatoid arthritis or lupus. Symptoms of undifferentiated connective tissue disease may vary but include constriction of the blood vessels in the hands and feet, especially in response to cold (Raynaud phenomenon), sensitivity to light, joint pain (arthralgia), muscle weakness, and dryness in the eyes and mouth. Undifferentiated connective tissue disease is most likely to occur in Caucasian women in their 40s-60s. Undifferentiated connective tissue disease is a type of autoimmune disease. This means that the system of the body that is responsible for protection from infection (immune system) is attacking the body itself. The cause of most autoimmune diseases is unknown, but is thought to include both environmental and genetic factors. Diagnosis of undifferentiated connective tissue disease can be obtained through blood tests and imaging (CT scan) of the chest. Treatment includes non-steroidal anti-inflammatory drugs (NSAIDs) and avoiding exposure to extreme temperatures.  Last updated: 10/31/2016

MalaCards based summary : Undifferentiated Connective Tissue Disease, also known as undifferentiated connective tissue syndrome, is related to connective tissue disease and pneumonia. An important gene associated with Undifferentiated Connective Tissue Disease is SSB (Sjogren Syndrome Antigen B). The drugs Vaccines and Immunoglobulins have been mentioned in the context of this disorder. Affiliated tissues include testes, eye and lung.

Wikipedia : 72 Undifferentiated connective tissue disease (UCTD) is a disease in which the body mistakenly attacks its... more...

Related Diseases for Undifferentiated Connective Tissue Disease

Graphical network of the top 20 diseases related to Undifferentiated Connective Tissue Disease:



Diseases related to Undifferentiated Connective Tissue Disease

Symptoms & Phenotypes for Undifferentiated Connective Tissue Disease

Drugs & Therapeutics for Undifferentiated Connective Tissue Disease

Drugs for Undifferentiated Connective Tissue Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines
2 Immunoglobulins
3 Antibodies
4 Autoantibodies

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Undifferentiated Connective Tissue Disease Registry Recruiting NCT02234388
2 Metabolomic Analysis of Systemic Sclerosis Recruiting NCT02298777
3 Comparative Autoantibody and Immunologic Cell Marker Study Enrolling by invitation NCT02422875

Search NIH Clinical Center for Undifferentiated Connective Tissue Disease

Genetic Tests for Undifferentiated Connective Tissue Disease

Anatomical Context for Undifferentiated Connective Tissue Disease

MalaCards organs/tissues related to Undifferentiated Connective Tissue Disease:

38
Testes, Eye, Lung, Bone, Endothelial, T Cells, Heart

Publications for Undifferentiated Connective Tissue Disease

Articles related to Undifferentiated Connective Tissue Disease:

(show top 50) (show all 83)
# Title Authors Year
1
Podocyte Infolding Glomerulopathy (PIG) in a Patient With Undifferentiated Connective Tissue Disease: A CaseA Report. ( 29395482 )
2018
2
Overlap of interstitial pneumonia with autoimmune features with undifferentiated connective tissue disease and contribution of UIP to mortality. ( 29320807 )
2018
3
Undifferentiated connective tissue disease: predictors of evolution into definite disease. ( 28770704 )
2017
4
Intracranial lesion as onset symptom in a patient with early undifferentiated connective tissue disease: a case report. ( 28476103 )
2017
5
Undifferentiated connective tissue disease, fibromyalgia and the environmental factors. ( 28368979 )
2017
6
Cardiac involvement in undifferentiated connective tissue disease at risk for systemic sclerosis (otherwise referred to as very early-early systemic sclerosis): a TDI study. ( 28993902 )
2017
7
Primary anetoderma with undifferentiated connective tissue disease. ( 29447658 )
2017
8
Are the autoimmune/inflammatory syndrome induced by adjuvants (ASIA) and the undifferentiated connective tissue disease (UCTD) related to each other? A case-control study of environmental exposures. ( 28332072 )
2017
9
Application of SLICC classification criteria in undifferentiated connective tissue disease and evolution in systemic lupus erythematosus: analysis of a large monocentric cohort with a long-term follow-up. ( 27703051 )
2016
10
Undifferentiated connective tissue disease and interstitial lung disease: Trying to define patterns. ( 27979657 )
2016
11
The clinical impact of Anti-DFS70 antibodies in undifferentiated connective tissue disease: case reports and a review of the literature. ( 27427300 )
2016
12
Undifferentiated Connective Tissue Disease, Mixed Connective Tissue Disease, and Overlap Syndromes in Rheumatology. ( 27311225 )
2016
13
CXCL4 in undifferentiated connective tissue disease at risk for systemic sclerosis (SSc) (previously referred to as very early SSc). ( 27650429 )
2016
14
Case Report and Literature Review: Quinacrine-induced Cholestatic Hepatitis in Undifferentiated Connective Tissue Disease. ( 26136554 )
2015
15
Broader criteria of undifferentiated connective tissue disease in idiopathic interstitial pneumonias. ( 25682542 )
2015
16
High prevalence of gluten sensitivity in a cohort of patients with undifferentiated connective tissue disease. ( 25781195 )
2015
17
Interstitial pneumonia with autoimmune features and undifferentiated connective tissue disease: Our interdisciplinary rheumatology-pneumology experience, and review of the literature. ( 26384526 )
2015
18
Mechanic's hands in a woman with undifferentiated connective tissue disease and interstitial lung disease - anti-PL7 positive antisynthetase syndrome: a case report. ( 25888844 )
2015
19
Undifferentiated Connective Tissue Disease at risk for systemic sclerosis (SSc) (so far referred to as very early/early SSc or pre-SSc). ( 25461837 )
2015
20
Impaired endothelial function in patients with undifferentiated connective tissue disease: a follow-up study. ( 24917564 )
2014
21
Recurrent epistaxis revealing a non-catheter-related superior vena cava syndrome in a hemodialysis patient: Unmasking undifferentiated connective tissue disease. ( 24434394 )
2014
22
Vocal fold bamboo nodes in undifferentiated connective tissue disease. ( 25118316 )
2014
23
Cytokine Milieu in Undifferentiated Connective Tissue Disease: a Comprehensive Review. ( 25274451 )
2014
24
Interstitial Pneumonia Related to Undifferentiated Connective Tissue Disease: Pathologic Pattern and Prognosis. ( 25211168 )
2014
25
Increased expression of vascular endothelial growth factor in a case of protein-losing enteropathy with undifferentiated connective tissue disease. ( 24899168 )
2014
26
Altered Th17 cells and Th17/regulatory T-cell ratios indicate the subsequent conversion from undifferentiated connective tissue disease to definitive systemic autoimmune disorders. ( 23974054 )
2013
27
Quality of life as measured by the short-form 36 (SF-36) questionnaire in patients with early systemic sclerosis and undifferentiated connective tissue disease. ( 23442975 )
2013
28
Conductor of regulatory cells: does vitamin D restore the shifted balance of the distinct regulatory cell types in undifferentiated connective tissue disease? ( 23500533 )
2013
29
Capillaroscopic pattern in systemic lupus erythematosus and undifferentiated connective tissue disease: what we still have to learn? ( 22527142 )
2013
30
Hepatitis B vaccination and undifferentiated connective tissue disease: another brick in the wall of the autoimmune/inflammatory syndrome induced by adjuvants (Asia). ( 23884184 )
2013
31
Undifferentiated connective tissue disease in a rheumatology center in Cali, Colombia: clinical features of 94 patients followed for a year. ( 22116525 )
2013
32
Comparison of characteristics of connective tissue disease-associated interstitial lung diseases, undifferentiated connective tissue disease-associated interstitial lung diseases, and idiopathic pulmonary fibrosis in Chinese Han population: a retrospective study. ( 24171031 )
2013
33
Recurrent orbital myositis in undifferentiated connective tissue disease. ( 22840478 )
2013
34
Assessment of T regulatory cells and expanded profiling of autoantibodies may offer novel biomarkers for the clinical management of systemic sclerosis and undifferentiated connective tissue disease. ( 23818915 )
2013
35
Intrapleural corticosteroid injection in eosinophilic pleural effusion associated with undifferentiated connective tissue disease. ( 24265645 )
2013
36
Acute fibrinous and organizing pneumonia and undifferentiated connective tissue disease: a case report. ( 22957292 )
2012
37
An unusual case of undifferentiated connective tissue disease presenting as cardiac tamponade. ( 20013265 )
2012
38
Pregnancy in patients with undifferentiated connective tissue disease: a prospective case-control study. ( 21813586 )
2011
39
Undifferentiated connective tissue disease presenting with prevalent interstitial lung disease: case report and review of literature. ( 21645423 )
2011
40
Undifferentiated connective tissue disease with pulmonary involvement. ( 21751630 )
2011
41
Alfacalcidol treatment restores derailed immune-regulation in patients with undifferentiated connective tissue disease. ( 20868777 )
2011
42
Undifferentiated connective tissue disease-associated interstitial lung disease: changes in lung function. ( 20069430 )
2010
43
Distinct prognosis of idiopathic nonspecific interstitial pneumonia (NSIP) fulfilling criteria for undifferentiated connective tissue disease (UCTD). ( 20483576 )
2010
44
Undifferentiated connective tissue disease - an unsolved problem:revision of literature and case studies. ( 20378013 )
2010
45
A case of hypertrophic cranial pachymeningitis presenting with scleritis in a patient with undifferentiated connective tissue disease. ( 20514324 )
2010
46
Late onset of pANCA renal and pulmonary vasculitis in a girl affected by undifferentiated connective tissue disease. ( 20133348 )
2010
47
Impaired regulatory T-cell homeostasis due to vitamin D deficiency in undifferentiated connective tissue disease. ( 20615161 )
2010
48
Undifferentiated connective tissue disease: a seven-center cross-sectional study of 184 patients. ( 19390908 )
2009
49
Neonatal lupus in triplet pregnancy of a patient with undifferentiated connective tissue disease evolving to systemic lupus erythematosus. ( 19276307 )
2009
50
Vitamin D deficiency in undifferentiated connective tissue disease. ( 18928561 )
2008

Variations for Undifferentiated Connective Tissue Disease

Expression for Undifferentiated Connective Tissue Disease

Search GEO for disease gene expression data for Undifferentiated Connective Tissue Disease.

Pathways for Undifferentiated Connective Tissue Disease

GO Terms for Undifferentiated Connective Tissue Disease

Sources for Undifferentiated Connective Tissue Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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