UES
MCID: UND001
MIFTS: 43

Undifferentiated Embryonal Sarcoma of the Liver (UES) malady

Liver diseases, Cancer diseases, Rare diseases categories
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Summaries for Undifferentiated Embryonal Sarcoma of the Liver

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33MalaCards
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MalaCards: Undifferentiated Embryonal Sarcoma of the Liver, also known as undifferentiated sarcoma of the liver, is related to sarcoma and rhabdomyosarcoma. An important gene associated with Undifferentiated Embryonal Sarcoma of the Liver is CDK4 (cyclin-dependent kinase 4), and among its related pathways are Akt Signaling Pathway and Chronic myeloid leukemia. The compounds roscovitine and benzo(a)pyrene have been mentioned in the context of this disorder. Affiliated tissues include liver, brain and lung, and related mouse phenotypes are tumorigenesis and muscle.

Aliases & Classifications for Undifferentiated Embryonal Sarcoma of the Liver

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49Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Anatomical: Liver diseases


Aliases & Descriptions:

undifferentiated embryonal sarcoma of the liver 49
undifferentiated sarcoma of the liver 49
embryonal sarcoma of the liver 49
ues 49


Related Diseases for Undifferentiated Embryonal Sarcoma of the Liver

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17GeneCards, 18GeneDecks
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Diseases related to Undifferentiated Embryonal Sarcoma of the Liver via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 54)
idRelated DiseaseScoreTop Affiliating Genes
1sarcoma31.9CDK4, MDM2, MYOD1, MYOG
2rhabdomyosarcoma30.5MDM2, MYOD1, MYOG, CDK4
3embryonal sarcoma11.3
4appendicitis10.4
5fibrous histiocytoma10.4
6systemic lupus erythematosus10.4
7eosinophilia10.4
8hepatitis10.4
9hepatoblastoma10.4
10histiocytoma10.4
11lupus erythematosus10.4
12angiosarcoma10.3
13hellp syndrome10.3
14laryngitis10.2
15malignant mesenchymoma10.1MYOD1, MYOG
16alveolar soft part sarcoma10.1MYOG, MYOD1
17myotonic dystrophy10.1MYOD1, MYOG
18polycystic kidney disease10.0
19kidney disease10.0
20malignant peripheral nerve sheath tumor10.0MDM2, MYOG
21neuropathy10.0MYOG, MYOD1
22embryonal cancer10.0MYOD1, MYOG
23dedifferentiated liposarcoma10.0MDM2, CDK4
24myxoid liposarcoma10.0CDK4, MDM2
25anaplastic oligodendroglioma10.0CDK4, MDM2
26lipoma10.0CDK4, MDM2
27liposarcoma10.0CDK4, MDM2
28intraocular melanoma10.0MDM2, CDK4
29wilms tumor10.0MYOD1, MYOG
30anaplastic astrocytoma10.0MDM2, CDK4
31acute lymphoblastic leukemia, childhood10.0MDM2, CDK4
32oligodendroglioma10.0MDM2, CDK4
33esophageal cancer10.0CDK4, MDM2
34oral cancer10.0MDM2, CDK4
35nasopharynx carcinoma10.0CDK4, MDM2
36chondrosarcoma10.0CDK4, MDM2
37embryonal rhabdomyosarcoma10.0CDK4, MYOD1, MYOG
38benign mesothelioma10.0MYOD1, MYOG, CDK4
39glioblastoma multiforme10.0CDK4, MDM2
40burkitt's lymphoma10.0MDM2, CDK4
41peripheral primitive neuroectodermal tumor10.0MYOG, MYOD1, MDM2
42non-small cell lung carcinoma10.0MDM2, CDK4
43chronic lymphocytic leukemia10.0CDK4, MDM2
44osteosarcoma10.0MYOD1, MDM2, CDK4
45adenocarcinoma10.0CDK4, MDM2
46colon cancer10.0MYOD1, CDK4, MDM2
47lung benign neoplasm10.0CDK4, MDM2
48alveolar rhabdomyosarcoma9.9MYOG, CDK4, MDM2, MYOD1
49malignant fibroxanthoma9.9CDK4, MDM2, MYOG, MYOD1
50leiomyosarcoma9.9CDK4, MYOG, MDM2, MYOD1

Graphical network of the top 20 diseases related to Undifferentiated Embryonal Sarcoma of the Liver:



Diseases related to undifferentiated embryonal sarcoma of the liver

Symptoms for Undifferentiated Embryonal Sarcoma of the Liver

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Drugs & Therapeutics for Undifferentiated Embryonal Sarcoma of the Liver

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Undifferentiated Embryonal Sarcoma of the Liver

Search NIH Clinical Center for Undifferentiated Embryonal Sarcoma of the Liver

Genetic Tests for Undifferentiated Embryonal Sarcoma of the Liver

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Anatomical Context for Undifferentiated Embryonal Sarcoma of the Liver

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33MalaCards
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MalaCards organs/tissues related to Undifferentiated Embryonal Sarcoma of the Liver:

33
Liver, Brain, Lung, Heart, Smooth muscle, Adrenal gland

Animal Models for Undifferentiated Embryonal Sarcoma of the Liver or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Undifferentiated Embryonal Sarcoma of the Liver:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.0CDK4, MDM2, MYOD1
2MP:00053698.5CDK4, MDM2, MYOG, MYOD1
3MP:00028738.3MYOD1, MYOG, MALAT1, MDM2
4MP:00053787.6PEG3, MYOD1, MYOG, MDM2, CDK4
5MP:00107687.3PEG3, MYOD1, MYOG, MDM2, CDK4

Publications for Undifferentiated Embryonal Sarcoma of the Liver

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52PubMed
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Articles related to Undifferentiated Embryonal Sarcoma of the Liver:

(show top 50)    (show all 70)
idTitleAuthorsYear
1
Management of undifferentiated embryonal sarcoma of the liver in children: a case series and management review. (24079623)
2013
2
Treatment of undifferentiated embryonal sarcoma of the liver in children--single center experience. (24210186)
2013
3
Undifferentiated embryonal sarcoma of the liver with focal osteoid picture-a case report. (24054758)
2013
4
Undifferentiated embryonal sarcoma of the liver in a middle-aged adult with systemic lupus erythematosus. (24073982)
2013
5
Characterization of translocations in mesenchymal hamartoma and undifferentiated embryonal sarcoma of the liver. (24120702)
2013
6
Molecular cytogenetic characterization of undifferentiated embryonal sarcoma of the liver: a case report and literature review. (22551002)
2012
7
Radiologic-pathologic comparison of undifferentiated embryonal sarcoma of the liver in a 61-year-old woman. (22421287)
2012
8
Undifferentiated embryonal sarcoma of the liver presenting as a hemorrhagic cystic tumor in an adult. (22146632)
2011
9
Undifferentiated embryonal sarcoma of the liver is associated with mesenchymal hamartoma and multiple chromosomal abnormalities: a review of eleven cases. (20925497)
2011
10
Paradoxical hepatic tumor: Undifferentiated embryonal sarcoma of the liver. (20352000)
2010
11
Adult primary undifferentiated embryonal sarcoma of the liver: a case report. (20137381)
2010
12
Fine needle aspiration cytology of undifferentiated embryonal sarcoma of the liver. (20105209)
2010
13
Primary undifferentiated embryonal sarcoma of the liver mistaken for hydatid disease. (20615265)
2010
14
Resection of a large, ruptured, undifferentiated (embryonal) sarcoma of the liver in a child: a case report and review of the literature. (19278169)
2009
15
F-18 FDG PET/CT findings in a case of undifferentiated embryonal sarcoma of the liver with lung and adrenal gland metastasis in a child. (19352266)
2009
16
Undifferentiated (embryonal) sarcoma of the liver: an intriguing diagnosis in a child. (19242910)
2009
17
Undifferentiated embryonal sarcoma of the liver: case report and literature survey. (18836810)
2008
18
Undifferentiated embryonal sarcoma of the liver in adults. (18361435)
2008
19
Undifferentiated embryonal sarcoma of the liver in a child complicated by haemorrhage. (18688607)
2008
20
Management of undifferentiated embryonal sarcoma of the liver in pregnancy. (17267894)
2007
21
Undifferentiated (embryonal) sarcoma of the liver complicated with rupture in a child. (17230070)
2007
22
Non-random p53 mutations in pediatric undifferentiated (embryonal) sarcoma of the liver. (16757210)
2006
23
A 51-year-old woman with a liver mass. Undifferentiated embryonal sarcoma of the liver. (16454576)
2006
24
Improved survival with surgery and systemic chemotherapy for undifferentiated embryonal sarcoma of the liver. (16259353)
2005
25
Undifferentiated (embryonal) sarcoma of the liver (USL): MRI findings including dynamic gadolinium enhancement. (15234460)
2004
26
Undifferentiated (embryonal) sarcoma of the liver in middle-aged adults: smooth muscle differentiation determined by immunohistochemistry and electron microscopy. (12673559)
2003
27
Undifferentiated (embryonal) sarcoma of the liver: case report and review of the literature. (19861818)
2003
28
Comparative genomic hybridization detects multiple chromosomal amplifications and deletions in undifferentiated embryonal sarcoma of the liver. (11376805)
2001
29
Undifferentiated embryonal sarcoma of the liver: results of clinical management in one center. (10591560)
1999
30
Fine needle aspiration cytology of undifferentiated embryonal sarcoma of the liver: a case report. (11068415)
1999
31
Hepatoblastomas and undifferentiated (embryonal) sarcoma of the liver: updating references while revising galley proofs. (9568154)
1998
32
Undifferentiated (embryonal) sarcoma of the liver: fine-needle aspiration cytology and preoperative chemotherapy as an approach to diagnosis and initial treatment. A case report. (9702485)
1998
33
Undifferentiated (embryonal) sarcoma of the liver: pathologic basis of imaging findings in 28 cases. (9169704)
1997
34
Fine needle aspiration cytology of undifferentiated (embryonal) sarcoma of the liver. A case report. (9990257)
1997
35
Primary multilocular cystic undifferentiated (embryonal) sarcoma of the liver in childhood resembling hydatid cyst of the liver. (9166061)
1997
36
Undifferentiated embryonal sarcoma of the liver in childhood. (8772820)
1995
37
Undifferentiated embryonal sarcoma of the liver treated with chemotherapy: CT imaging in four patients. (7787716)
1995
38
Undifferentiated (embryonal) sarcoma of the liver in adults. (7893087)
1995
39
Cytopathology of undifferentiated (embryonal) sarcoma of the liver. (7587875)
1995
40
Undifferentiated (embryonal) sarcoma of the liver in an adult patient with metastasis of the heart and brain. (8012163)
1994
41
Primary multicystic undifferentiated embryonal sarcoma of the liver in an adult presenting with peripheral eosinophilia. (7847778)
1994
42
Undifferentiated (embryonal) sarcoma of the liver in childhood. Successful combined-modality therapy in four patients. (8402469)
1993
43
Undifferentiated (embryonal) sarcoma of the liver. Pathologic findings and long-term survival after complete surgical resection. (1727675)
1992
44
Undifferentiated (embryonal) sarcoma of the liver. A tumor of uncertain histogenesis showing divergent differentiation. (1711792)
1991
45
Undifferentiated (embryonal) sarcoma of the liver: ultrastructure, immunohistochemistry, and DNA ploidy analysis of two cases. (2371180)
1990
46
Undifferentiated (embryonal) sarcoma of the liver. Epithelial features as shown by immunohistochemical analysis and electron microscopic examination. (2680050)
1989
47
Undifferentiated (embryonal) sarcoma of the liver in childhood: report of two cases. (4009092)
1985
48
Undifferentiated (embryonal) sarcoma of the liver with alpha-1-antitrypsin deposits: immunohistochemical and ultrastructural studies. (6992971)
1980
49
Undifferentiated (embryonal) sarcoma of the liver. (7395519)
1980
50
Undifferentiated (embryonal) sarcoma of the liver: report of 31 cases. (208754)
1978

Variations for Undifferentiated Embryonal Sarcoma of the Liver

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Expression for genes affiliated with Undifferentiated Embryonal Sarcoma of the Liver

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Undifferentiated Embryonal Sarcoma of the Liver

Search GEO for disease gene expression data for Undifferentiated Embryonal Sarcoma of the Liver.

Pathways for genes affiliated with Undifferentiated Embryonal Sarcoma of the Liver

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50PathCards, 54R&D Systems, 30KEGG, 38NCBI BioSystems Database, 60Thomson Reuters, 55Reactome, 53QIAGEN, 57SinoBiological
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Pathways related to Undifferentiated Embryonal Sarcoma of the Liver according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6CDK4, MDM2
2
Show member pathways
9.6MDM2, CDK4
39.6CDK4, MDM2
4
Show member pathways
DNA damage response38
9.6CDK4, MDM2
5
Show member pathways
Prostate Cancer38
Integrated Cancer pathway38
Steroid Biosynthesis38
9.6CDK4, MDM2
69.6CDK4, MDM2
79.6CDK4, MDM2
89.6MDM2, CDK4
9
Show member pathways
Cell cycle38
9.6CDK4, MDM2
10
Show member pathways
9.6CDK4, MDM2
119.6CDK4, MDM2
129.4MYOD1, CDK4
139.4MDM2, MYOD1
149.3MYOD1, MYOG
15
Show member pathways
9.3MYOG, MYOD1
16
Show member pathways
Development Role of HDAC and calcium calmodulin dependent kinase CaMK in control of skeletal myogenesis60
9.3MYOD1, MYOG
17
Show member pathways
8.9CDK4, MYOG, MYOD1

Compounds for genes affiliated with Undifferentiated Embryonal Sarcoma of the Liver

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45Novoseek, 51PharmGKB, 11DrugBank, 61Tocris Bioscience, 24HMDB
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Compounds related to Undifferentiated Embryonal Sarcoma of the Liver according to GeneCards/GeneDecks:

(show all 42)
idCompoundScoreTop Affiliating Genes
1roscovitine4510.0CDK4, MDM2
2benzo(a)pyrene4510.0CDK4, MDM2
3fludarabine45 51 1112.0CDK4, MDM2
4flavopiridol45 1110.9CDK4, MDM2
5trastuzumab45 51 1111.9MDM2, CDK4
6gefitinib45 51 1111.9MDM2, CDK4
7carboplatin45 51 1111.9CDK4, MDM2
8adpribose459.9CDK4, MDM2
9sp 60012545 6110.9CDK4, MDM2
10lead459.9MDM2, CDK4
11thymidylate459.8MDM2, CDK4
12resveratrol45 61 24 1112.7CDK4, MDM2
13camptothecin45 61 1111.5CDK4, MDM2
14rapamycin459.5CDK4, MDM2, MYOG
15pd 98,059459.5CDK4, MDM2, MYOG
16ly294002459.5MYOG, MDM2, CDK4
17tgf beta1459.4CDK4, MYOD1
18geldanamycin45 51 61 1112.4CDK4, MDM2, MYOD1
19lactacystin459.4MYOD1, MDM2, CDK4
20bromodeoxyuridine459.3CDK4, MYOG, MYOD1
21cyclic amp45 2410.3MYOD1, MDM2, CDK4
2212-o-tetradecanoylphorbol 13-acetate459.3CDK4, MYOG, MYOD1
23butyrate459.3MYOD1, MYOG, CDK4
24nitric oxide45 24 1111.3CDK4, MDM2, MYOG
25arginine459.2CDK4, MDM2, MYOD1
26phosphatidylinositol459.2MYOD1, MDM2, CDK4
27threonine459.1MYOD1, MDM2, CDK4
28mg 13245 6110.1MDM2, MYOD1
29alanine459.0MYOD1, MDM2, CDK4
305-aza-2deoxycytidine459.0PEG3, MYOD1, MDM2
31paraffin458.9MYOD1, MYOG, MDM2, CDK4
32testosterone45 61 24 1111.9MYOD1, MYOG, MDM2, CDK4
33steroid458.9MYOD1, MYOG, MDM2, CDK4
34oligonucleotide458.9CDK4, MDM2, MYOG, MYOD1
35oxygen45 249.9MYOD1, MYOG, MDM2, CDK4
36estrogen458.9CDK4, MDM2, MYOG, MYOD1
37cysteine458.9MYOD1, MYOG, MDM2, CDK4
38serine458.8MYOD1, MYOG, MDM2, CDK4
39tyrosine458.8CDK4, MDM2, MYOG, MYOD1
40calcium45 51 24 1111.6MYOD1, MYOG, MDM2, CDK4
41zinc45 249.6CDK4, MDM2, MYOD1, PEG3
42vegf458.1CDK4, MDM2, MYOG, MYOD1, PEG3

GO Terms for genes affiliated with Undifferentiated Embryonal Sarcoma of the Liver

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16Gene Ontology
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Cellular components related to Undifferentiated Embryonal Sarcoma of the Liver according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transcription factor complexGO:0056678.8CDK4, MYOG, MYOD1
2nucleoplasmGO:0056548.2MYOD1, MYOG, MDM2, CDK4
3nucleusGO:0056347.6CDK4, MDM2, MYOG, MYOD1, PEG3

Biological processes related to Undifferentiated Embryonal Sarcoma of the Liver according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of cell cycle arrestGO:0711579.7CDK4, MDM2
2muscle cell fate commitmentGO:0426939.5MYOG, MYOD1
3skeletal muscle fiber developmentGO:0487419.4MYOG, MYOD1
4cellular response to estradiol stimulusGO:0713929.3MYOD1, MYOG
5skeletal muscle tissue developmentGO:0075199.3MYOG, MYOD1
6positive regulation of muscle cell differentiationGO:0511499.2MYOG, MYOD1
7muscle cell differentiationGO:0426929.0MYOG, MYOD1

Molecular functions related to Undifferentiated Embryonal Sarcoma of the Liver according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1core promoter bindingGO:0010479.3MYOG, MYOD1
2chromatin DNA bindingGO:0314909.2MYOG, MYOD1
3E-box bindingGO:0708889.0MYOG, MYOD1

Products for genes affiliated with Undifferentiated Embryonal Sarcoma of the Liver

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Sources for Undifferentiated Embryonal Sarcoma of the Liver

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet