UES
MCID: UND001
MIFTS: 24

Undifferentiated Embryonal Sarcoma of the Liver (UES) malady

Liver, Cancer categories

Summaries for Undifferentiated Embryonal Sarcoma of the Liver

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33MalaCards
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MalaCards: Undifferentiated Embryonal Sarcoma of the Liver, also known as undifferentiated sarcoma of the liver, is related to angiosarcoma and embryonal sarcoma. An important gene associated with Undifferentiated Embryonal Sarcoma of the Liver is SERPINA3 (serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3), and among its related pathways are Regulation of nuclear SMAD2/3 signaling and Chronic myeloid leukemia. The compounds creatinine and fludarabine have been mentioned in the context of this disorder. Affiliated tissues include liver, and related mouse phenotype muscle.

Aliases & Classifications for Undifferentiated Embryonal Sarcoma of the Liver

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49Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Liver


Aliases & Descriptions:

undifferentiated embryonal sarcoma of the liver 49
undifferentiated sarcoma of the liver 49
embryonal sarcoma of the liver 49
ues 49


Related Diseases for Undifferentiated Embryonal Sarcoma of the Liver

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17GeneCards, 18GeneDecks
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Diseases related to Undifferentiated Embryonal Sarcoma of the Liver via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 46)
idRelated DiseaseScoreTop Affiliating Genes
1angiosarcoma30.4SERPINA3
2embryonal sarcoma11.3
3fibrous histiocytoma10.4
4systemic lupus erythematosus10.4
5liver rhabdomyosarcoma10.4
6brain sarcoma10.4
7appendicitis10.4
8liver angiosarcoma10.3
9hellp syndrome10.3
10polycystic kidney disease10.0
11fibrosarcoma10.0MDM2
12alveolar soft part sarcoma10.0MYOD1
13rhabdoid tumor10.0MYOD1
14malignant mesothelioma10.0CDK4
15insulin resistance10.0MYOD1
16malignant peripheral nerve sheath tumor10.0MDM2, MYOG
17malignant mesenchymoma10.0MYOG, MYOD1
18wilms tumor10.0MYOG, MYOD1
19dedifferentiated liposarcoma10.0CDK4, MDM2
20myxoid liposarcoma10.0CDK4, MDM2
21anaplastic oligodendroglioma10.0CDK4, MDM2
22intraocular melanoma10.0CDK4, MDM2
23acute lymphoblastic leukemia, childhood10.0CDK4, MDM2
24esophageal cancer10.0MDM2, CDK4
25lipoma10.0CDK4, MDM2
26anaplastic astrocytoma10.0CDK4, MDM2
27nasopharynx carcinoma10.0CDK4, MDM2
28peripheral primitive neuroectodermal tumor10.0MDM2, MYOD1, MYOG
29chondrosarcoma10.0MDM2, CDK4, SERPINA3
30glioblastoma multiforme10.0MDM2, CDK4
31breast cancer10.0SERPINA3, CDK4, MDM2
32embryonal rhabdomyosarcoma10.0CDK4, MYOG, MYOD1
33benign mesothelioma10.0CDK4, MYOG, MYOD1
34malignant glioma10.0SERPINA3, CDK4, MDM2
35osteosarcoma10.0MDM2, MYOD1, CDK4
36lung cancer10.0MDM2, CDK4, SERPINA3
37squamous cell carcinoma10.0SERPINA3, CDK4, MDM2
38burkitt's lymphoma10.0CDK4, MYOD1, MDM2
39alveolar rhabdomyosarcoma10.0MDM2, MYOD1, MYOG, CDK4
40leiomyosarcoma10.0CDK4, MYOG, MYOD1, MDM2
41rhabdomyosarcoma10.0MDM2, MYOD1, MYOG, CDK4
42astrocytoma10.0SERPINA3, CDK4, MDM2
43sarcoma10.0CDK4, MYOG, MYOD1, MDM2
44retinoblastoma10.0MDM2, MYOD1, MYOG, CDK4
45melanoma10.0SERPINA3, CDK4, MYOD1, MDM2
46malignant fibroxanthoma10.0SERPINA3, CDK4, MYOG, MYOD1, MDM2

Graphical network of the top 20 diseases related to Undifferentiated Embryonal Sarcoma of the Liver:



Diseases related to undifferentiated embryonal sarcoma of the liver

Clinical Features for Undifferentiated Embryonal Sarcoma of the Liver

Drugs & Therapeutics for Undifferentiated Embryonal Sarcoma of the Liver

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Undifferentiated Embryonal Sarcoma of the Liver

Drug clinical trials:

Search ClinicalTrials for Undifferentiated Embryonal Sarcoma of the Liver

Search NIH Clinical Center for Undifferentiated Embryonal Sarcoma of the Liver

Search CenterWatch for Undifferentiated Embryonal Sarcoma of the Liver

Genetic Tests for Undifferentiated Embryonal Sarcoma of the Liver

Anatomical Context for Undifferentiated Embryonal Sarcoma of the Liver

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33MalaCards
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MalaCards organs/tissues related to Undifferentiated Embryonal Sarcoma of the Liver:

33
Liver

Animal Models for Undifferentiated Embryonal Sarcoma of the Liver or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Undifferentiated Embryonal Sarcoma of the Liver:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.8CDK4, MYOD1, MDM2

Publications for Undifferentiated Embryonal Sarcoma of the Liver

Genetic Variations for Undifferentiated Embryonal Sarcoma of the Liver

Expression for genes affiliated with Undifferentiated Embryonal Sarcoma of the Liver

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Undifferentiated Embryonal Sarcoma of the Liver

Search GEO for disease gene expression data for Undifferentiated Embryonal Sarcoma of the Liver.

Pathways for genes affiliated with Undifferentiated Embryonal Sarcoma of the Liver

Sources:
38NCBI BioSystems Database, 30KEGG, 56SinoBiological, 52QIAGEN, 12EMD Millipore, 53R&D Systems
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Compounds for genes affiliated with Undifferentiated Embryonal Sarcoma of the Liver

Sources:
45Novoseek, 11DrugBank, 50PharmGKB, 60Tocris Bioscience, 24HMDB, 29IUPHAR
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Compounds related to Undifferentiated Embryonal Sarcoma of the Liver according to GeneCards/GeneDecks:

(show all 45)
idCompoundScoreTop Affiliating Genes
1creatinine459.8SERPINA3, MYOD1
2fludarabine45 1110.6CDK4, MDM2
3roscovitine459.6MDM2, CDK4
4benzo(a)pyrene459.6CDK4, MDM2
5flavopiridol45 1110.6MDM2, CDK4
6trastuzumab45 50 1111.6CDK4, MDM2
7carboplatin45 50 1111.5MDM2, CDK4
8gefitinib45 50 1111.4MDM2, CDK4
9adpribose459.4MDM2, CDK4
10thymidylate459.3CDK4, MDM2
11valine459.3SERPINA3, CDK4, MDM2
12leucine459.2SERPINA3, CDK4, MYOD1
13geldanamycin45 50 60 1112.2CDK4, MYOD1, MDM2
14sp 60012545 6010.2MDM2, CDK4
15lactacystin459.2MDM2, MYOD1, CDK4
16estradiol45 11 2411.2SERPINA3, CDK4, MDM2
17iron45 2410.2MDM2, CDK4, SERPINA3
18progesterone45 60 29 11 2413.1SERPINA3, CDK4, MDM2
19lead459.0CDK4, MDM2
20cyclic amp45 2410.0CDK4, MYOD1, MDM2
21acetylcholine45 50 29 11 2413.0MYOD1, MYOG, SERPINA3
22bromodeoxyuridine459.0CDK4, MYOG, MYOD1
2312-o-tetradecanoylphorbol 13-acetate459.0CDK4, MYOG, MYOD1
24butyrate459.0CDK4, MYOG, MYOD1
25dexamethasone45 50 29 1111.9SERPINA3, CDK4, MDM2
26rapamycin458.9CDK4, MYOG, MDM2
27pd 98,059458.9CDK4, MYOG, MDM2
28ly294002458.8MDM2, MYOG, CDK4
29arginine458.8SERPINA3, CDK4, MYOD1, MDM2
30zinc45 249.8MDM2, MYOD1, CDK4, SERPINA3
31threonine458.7MDM2, MYOD1, CDK4, SERPINA3
32alanine458.7SERPINA3, CDK4, MYOD1, MDM2
33retinoic acid45 249.5SERPINA3, CDK4, MYOG, MYOD1
34glucose458.5MYOD1, MYOG, CDK4, SERPINA3
35testosterone45 60 11 2411.4MDM2, MYOD1, MYOG, CDK4
36vegf458.4MDM2, MYOD1, MYOG, CDK4
37tyrosine458.2MDM2, MYOD1, MYOG, CDK4
38paraffin458.0SERPINA3, CDK4, MYOG, MYOD1, MDM2
39steroid458.0MDM2, MYOD1, MYOG, CDK4, SERPINA3
40oligonucleotide458.0SERPINA3, CDK4, MYOG, MYOD1, MDM2
41oxygen45 249.0MDM2, MYOD1, MYOG, CDK4, SERPINA3
42estrogen458.0SERPINA3, CDK4, MYOG, MYOD1, MDM2
43cysteine458.0MDM2, MYOD1, MYOG, CDK4, SERPINA3
44serine457.9MDM2, MYOD1, MYOG, CDK4, SERPINA3
45calcium45 50 11 2410.9MDM2, MYOD1, MYOG, CDK4, SERPINA3

GO Terms for genes affiliated with Undifferentiated Embryonal Sarcoma of the Liver

Sources:
16Gene Ontology
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Cellular components related to Undifferentiated Embryonal Sarcoma of the Liver according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transcription factor complexGO:0056678.5CDK4, MYOG, MYOD1
2nucleoplasmGO:0056547.7MDM2, MYOD1, MYOG, CDK4
3nucleusGO:0056347.5SERPINA3, CDK4, MYOG, MYOD1, MDM2

Biological processes related to Undifferentiated Embryonal Sarcoma of the Liver according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1muscle cell fate commitmentGO:0426939.2MYOG, MYOD1
2skeletal muscle fiber developmentGO:0487419.2MYOG, MYOD1
3cellular response to estradiol stimulusGO:0713929.1MYOG, MYOD1
4skeletal muscle tissue developmentGO:0075199.1MYOG, MYOD1
5positive regulation of muscle cell differentiationGO:0511499.0MYOD1, MYOG
6muscle cell differentiationGO:0426928.8MYOG, MYOD1

Molecular functions related to Undifferentiated Embryonal Sarcoma of the Liver according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1E-box bindingGO:0708889.1MYOG, MYOD1
2chromatin DNA bindingGO:0314909.0MYOG, MYOD1
3core promoter bindingGO:0010478.8MYOG, MYOD1

Products for genes affiliated with Undifferentiated Embryonal Sarcoma of the Liver

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Undifferentiated Embryonal Sarcoma of the Liver

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet