UES
MCID: UND001
MIFTS: 36

Undifferentiated Embryonal Sarcoma of the Liver (UES) malady

Categories: Liver diseases, Rare diseases, Fetal diseases, Cancer diseases

Aliases & Classifications for Undifferentiated Embryonal Sarcoma of the Liver

Aliases & Descriptions for Undifferentiated Embryonal Sarcoma of the Liver:

Name: Undifferentiated Embryonal Sarcoma of the Liver 56
Undifferentiated Sarcoma of the Liver 56
Embryonal Sarcoma of the Liver 56
Ues 56

Classifications:

Orphanet: 56  
Rare hepatic diseases


External Ids:

Orphanet 56 ORPHA178315

Summaries for Undifferentiated Embryonal Sarcoma of the Liver

MalaCards based summary : Undifferentiated Embryonal Sarcoma of the Liver, also known as undifferentiated sarcoma of the liver, is related to sarcoma and embryonal sarcoma. An important gene associated with Undifferentiated Embryonal Sarcoma of the Liver is CDK4 (Cyclin Dependent Kinase 4), and among its related pathways/superpathways are Regulation of nuclear SMAD2/3 signaling and Bladder cancer. The drugs Doxorubicin and Cisplatin have been mentioned in the context of this disorder. Affiliated tissues include liver, lung and adrenal gland.

Related Diseases for Undifferentiated Embryonal Sarcoma of the Liver

Diseases related to Undifferentiated Embryonal Sarcoma of the Liver via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 65)
id Related Disease Score Top Affiliating Genes
1 sarcoma 10.9
2 embryonal sarcoma 10.9
3 rommen mueller sybert syndrome 10.2 CDK4 MDM2
4 primary eye hypotony 10.2 CDK4 MDM2
5 osteomyelitis 10.2 CDK4 MDM2
6 aortic aneurysm 10.2 CDK4 MDM2
7 liposarcoma of bone 10.2 CDK4 MDM2
8 apocrine sweat gland neoplasm 10.2 CDK4 MDM2
9 bone leiomyosarcoma 10.2 CDK4 MDM2
10 localized hypertrophic neuropathy 10.2 CDK4 MDM2
11 episodic ataxia 10.2 CDK4 MDM2
12 intracranial liposarcoma 10.2 CDK4 MDM2
13 brain stem angioblastoma 10.2 CDK4 MDM2
14 house allergic alveolitis 10.2 CDK4 MDM2
15 pinta disease 10.2 CDK4 MDM2
16 pleural lipoma 10.2 CDK4 MDM2
17 childhood immature teratoma of ovary 10.2 CDK4 MDM2
18 conventional central osteosarcoma 10.2 CDK4 MDM2
19 liposarcoma of the ovary 10.2 CDK4 MDM2
20 metachronous osteosarcoma of the bone 10.1 CDK4 MDM2
21 interstitial lung disease 10.1 CDK4 MDM2
22 hepatitis 10.1
23 mixed type rhabdomyosarcoma 10.1 MYOD1 MYOG
24 testis sarcoma 10.1 MYOD1 MYOG
25 brain stem infarction 10.1 MYOD1 MYOG
26 stickler syndrome, type i 10.1 CDK4 MDM2
27 post-surgical hypoinsulinemia 10.1 CDK4 MDM2
28 extraosseous osteosarcoma 10.0 CDK4 MDM2 MYOD1
29 childhood medulloblastoma 10.0 MYOD1 MYOG
30 nodular tenosynovitis 10.0 MYOD1 MYOG
31 juvenile xanthogranuloma 10.0 MYOD1 SERPINA3
32 spindle cell rhabdomyosarcoma 10.0 MYOD1 MYOG
33 focal epithelial hyperplasia 10.0 MDM2 SERPINA3
34 blood protein disease 10.0 CDK4 MDM2 SERPINA3
35 multifocal osteogenic sarcoma 10.0 CDK4 MDM2 SERPINA3
36 kidney sarcoma 10.0 MYOD1 MYOG
37 extraocular retinoblastoma 10.0 CDK4 MDM2
38 gestational choriocarcinoma 10.0 CDK4 MDM2 SERPINA3
39 glucosephosphate isomerase deficiency 10.0 CDK4 MDM2 PEG3
40 endodermal sinus tumor 10.0 MDM2 MYOD1 SERPINA3
41 diabetes persistent mullerian ducts 10.0 MYOD1 MYOG
42 palmoplantar keratosis 10.0 CDK4 MDM2 MYOG
43 adenosarcoma 10.0 CDK4 MDM2 MYOG
44 prostate rhabdomyosarcoma 10.0 CDK4 MYOD1 MYOG
45 mediastinum rhabdomyosarcoma 10.0 CDK4 MYOD1 MYOG
46 mediastinum sarcoma 9.9 MDM2 MYOD1 MYOG
47 integumentary system benign neoplasm 9.9 CDK4 MDM2
48 laryngitis 9.9
49 rhabdomyosarcoma 9.9
50 histiocytoma 9.9

Graphical network of the top 20 diseases related to Undifferentiated Embryonal Sarcoma of the Liver:



Diseases related to Undifferentiated Embryonal Sarcoma of the Liver

Symptoms & Phenotypes for Undifferentiated Embryonal Sarcoma of the Liver

Drugs & Therapeutics for Undifferentiated Embryonal Sarcoma of the Liver

Drugs for Undifferentiated Embryonal Sarcoma of the Liver (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 46)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxorubicin Approved, Investigational Phase 2,Phase 1 23214-92-8 31703
2
Cisplatin Approved Phase 2 15663-27-1 84093 441203 2767
3
Tamoxifen Approved Phase 2 10540-29-1 2733526
4
Etoposide Approved Phase 1, Phase 2 33419-42-0 36462
5
Carboplatin Approved Phase 1, Phase 2 41575-94-4 10339178 498142 38904
6
Dasatinib Approved, Investigational Phase 1, Phase 2 302962-49-8 3062316
7
Ifosfamide Approved Phase 1, Phase 2 3778-73-2 3690
8
Mechlorethamine Approved Phase 1, Phase 2 51-75-2 4033
9
Doxil Approved June 1999 Phase 2,Phase 1 31703
10 Selective Estrogen Receptor Modulators Phase 2
11 Topoisomerase Inhibitors Phase 2,Phase 1
12 Hormone Antagonists Phase 2
13 Hormones Phase 2
14 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
15 Estrogen Antagonists Phase 2
16 Anti-Bacterial Agents Phase 2,Phase 1
17 Estrogen Receptor Modulators Phase 2
18 Estrogens Phase 2
19 Liver Extracts Phase 2,Phase 1
20 Antibiotics, Antitubercular Phase 2,Phase 1
21 Antineoplastic Agents, Hormonal Phase 2
22 Bone Density Conservation Agents Phase 2
23 Protein Kinase Inhibitors Phase 1, Phase 2
24 Alkylating Agents Phase 1, Phase 2
25 Etoposide phosphate Phase 1, Phase 2
26 Isophosphamide mustard Phase 1, Phase 2
27 Antineoplastic Agents, Alkylating Phase 1, Phase 2
28 Antineoplastic Agents, Phytogenic Phase 1, Phase 2
29 Citrate Nutraceutical Phase 2
30
Citric Acid Nutraceutical, Vet_approved Phase 2 77-92-9 311
31
Miconazole Approved, Investigational, Vet_approved Phase 1 22916-47-8 4189
32
Everolimus Approved Phase 1 159351-69-6 6442177
33
Sirolimus Approved, Investigational Phase 1 53123-88-9 5284616 6436030 46835353
34
Morphine Approved, Investigational Phase 1 57-27-2 5288826
35
Menthol Approved Phase 1 2216-51-5 16666
36
Trametinib Approved Phase 1 871700-17-3 11707110
37
Ceritinib Approved Phase 1 1032900-25-6
38 Vaccines Phase 1
39 Immunoglobulins Phase 1
40 Anti-Infective Agents Phase 1
41 Antibodies, Monoclonal Phase 1
42 Immunosuppressive Agents Phase 1
43 Antifungal Agents Phase 1
44 Antibodies Phase 1
45 Mitogens Phase 1
46 3-Iodobenzylguanidine Phase 1

Interventional clinical trials:


id Name Status NCT ID Phase
1 Combination Chemotherapy and Tamoxifen in Treating Patients With Solid Tumors Completed NCT00002608 Phase 2
2 Dasatinib, Ifosfamide, Carboplatin, and Etoposide in Treating Young Patients With Metastatic or Recurrent Malignant Solid Tumors Active, not recruiting NCT00788125 Phase 1, Phase 2
3 Cixutumumab and Doxorubicin Hydrochloride in Treating Patients With Unresectable, Locally Advanced, or Metastatic Soft Tissue Sarcoma Completed NCT00720174 Phase 1
4 Vaccine Therapy With or Without Sirolimus in Treating Patients With NY-ESO-1 Expressing Solid Tumors Completed NCT01522820 Phase 1
5 Next Generation Personalized Neuroblastoma Therapy Recruiting NCT02780128 Phase 1

Search NIH Clinical Center for Undifferentiated Embryonal Sarcoma of the Liver

Genetic Tests for Undifferentiated Embryonal Sarcoma of the Liver

Anatomical Context for Undifferentiated Embryonal Sarcoma of the Liver

MalaCards organs/tissues related to Undifferentiated Embryonal Sarcoma of the Liver:

39
Liver, Lung, Adrenal Gland, Smooth Muscle, Heart, Brain

Publications for Undifferentiated Embryonal Sarcoma of the Liver

Articles related to Undifferentiated Embryonal Sarcoma of the Liver:

(show top 50) (show all 89)
id Title Authors Year
1
The Role of Liver Transplantation in Undifferentiated Embryonal Sarcoma of the Liver in Children. ( 27438021 )
2016
2
Characteristics and outcomes in children with undifferentiated embryonal sarcoma of the liver: A report from the National Cancer Database. ( 27781381 )
2016
3
Imaging features of undifferentiated embryonal sarcoma of the liver: a series of 15 children. ( 27562247 )
2016
4
Undifferentiated embryonal sarcoma of the liver in an adult patient. ( 27377912 )
2016
5
Undifferentiated Embryonal Sarcoma of the Liver (UESL): A Single-Center Experience and Review of the Literature. ( 26925712 )
2016
6
A single-center experience with undifferentiated embryonal sarcoma of the liver. ( 27427850 )
2016
7
Undifferentiated embryonal sarcoma of the liver in a young female: treatment with portal vein embolization and liver trisectonectomy. ( 27621753 )
2016
8
Undifferentiated embryonal sarcoma of the liver with an unusual presentation: case report and review of the literature. ( 27034807 )
2016
9
Undifferentiated embryonal sarcoma of the liver: a concise review. ( 25611111 )
2015
10
Pre-operatively misdiagnosed undifferentiated embryonal sarcoma of the liver: analysis of 16 cases. ( 26807408 )
2015
11
Repeated hepatic resections and radio-frequency ablations may improve the survival of adult undifferentiated embryonal sarcoma of the liver: report of two cases. ( 26366352 )
2015
12
A case of an undifferentiated embryonal sarcoma of the liver mimicking a liver abscess. ( 25364566 )
2014
13
Undifferentiated embryonal sarcoma of the liver mistaken for hepatic abscess in an adult. ( 25120683 )
2014
14
Primary undifferentiated embryonal sarcoma of the liver misdiagnosed as hydatid cyst in a child: a case report and review of the literature. ( 25603636 )
2014
15
A Rare Case of Childhood Undifferentiated Embryonal Sarcoma of the Liver Managed Successfully. ( 26157829 )
2014
16
Remarkable regression of a lung recurrence from an undifferentiated embryonal sarcoma of the liver treated with a DC vaccine combined with immune cells: a case report. ( 25038546 )
2014
17
Diagnosis and therapy of primary undifferentiated embryonal sarcoma of the liver. ( 24762610 )
2014
18
Characterization of translocations in mesenchymal hamartoma and undifferentiated embryonal sarcoma of the liver. ( 24120702 )
2013
19
Treatment of undifferentiated embryonal sarcoma of the liver in children--single center experience. ( 24210186 )
2013
20
Undifferentiated embryonal sarcoma of the liver in a child: A case report and review of the literature. ( 23426588 )
2013
21
Management of undifferentiated embryonal sarcoma of the liver in children: a case series and management review. ( 24079623 )
2013
22
Undifferentiated embryonal sarcoma of the liver in a middle-aged adult with systemic lupus erythematosus. ( 24073982 )
2013
23
Undifferentiated embryonal sarcoma of the liver with focal osteoid picture-a case report. ( 24054758 )
2013
24
Undifferentiated embryonal sarcoma of the liver in an adult patient: case report. ( 22798120 )
2012
25
An undifferentiated embryonal sarcoma of the liver containing adipophilin-positive vesicles in an adult with massive sinusoidal invasion. ( 23071865 )
2012
26
Radiologic-pathologic comparison of undifferentiated embryonal sarcoma of the liver in a 61-year-old woman. ( 22421287 )
2012
27
Molecular cytogenetic characterization of undifferentiated embryonal sarcoma of the liver: a case report and literature review. ( 22551002 )
2012
28
Rare case of adult undifferentiated (embryonal) sarcoma of the liver treated with liver transplantation: excellent long-term survival. ( 25374706 )
2012
29
Undifferentiated embryonal sarcoma of the liver is associated with mesenchymal hamartoma and multiple chromosomal abnormalities: a review of eleven cases. ( 20925497 )
2011
30
Undifferentiated embryonal sarcoma of the liver presenting as a hemorrhagic cystic tumor in an adult. ( 22146632 )
2011
31
Diffuse membranous immunoreactivity of CD56 and paranuclear dot-like staining pattern of cytokeratins AE1/3, CAM5.2, and OSCAR in undifferentiated (embryonal) sarcoma of the liver. ( 19809302 )
2010
32
Primary undifferentiated embryonal sarcoma of the liver mistaken for hydatid disease. ( 20615265 )
2010
33
Adult primary undifferentiated embryonal sarcoma of the liver: a case report. ( 20137381 )
2010
34
Paradoxical hepatic tumor: Undifferentiated embryonal sarcoma of the liver. ( 20352000 )
2010
35
Fine needle aspiration cytology of undifferentiated embryonal sarcoma of the liver. ( 20105209 )
2010
36
Undifferentiated (embryonal) sarcoma of the liver. ( 19959514 )
2009
37
Diagnosis of undifferentiated embryonal sarcoma of the liver-importance of combined studies of ultrasound and CT scan. ( 19770684 )
2009
38
Resection of a large, ruptured, undifferentiated (embryonal) sarcoma of the liver in a child: a case report and review of the literature. ( 19278169 )
2009
39
Undifferentiated (embryonal) sarcoma of the liver: an intriguing diagnosis in a child. ( 19242910 )
2009
40
F-18 FDG PET/CT findings in a case of undifferentiated embryonal sarcoma of the liver with lung and adrenal gland metastasis in a child. ( 19352266 )
2009
41
Undifferentiated embryonal sarcoma of the liver. ( 18356418 )
2008
42
Undifferentiated embryonal sarcoma of the liver in adult. ( 18374056 )
2008
43
Undifferentiated embryonal sarcoma of the liver: case report and literature survey. ( 18836810 )
2008
44
Undifferentiated embryonal sarcoma of the liver in a child complicated by haemorrhage. ( 18688607 )
2008
45
Undifferentiated embryonal sarcoma of the liver in adults. ( 18361435 )
2008
46
Management of undifferentiated embryonal sarcoma of the liver in pregnancy. ( 17267894 )
2007
47
Undifferentiated (embryonal) sarcoma of the liver complicated with rupture in a child. ( 17230070 )
2007
48
Distinguishing undifferentiated embryonal sarcoma of the liver from biliary tract rhabdomyosarcoma: a Children's Oncology Group study. ( 17378682 )
2007
49
Undifferentiated embryonal sarcoma of the liver successfully treated with chemotherapy and liver resection. ( 17390190 )
2007
50
A 51-year-old woman with a liver mass. Undifferentiated embryonal sarcoma of the liver. ( 16454576 )
2006

Variations for Undifferentiated Embryonal Sarcoma of the Liver

Expression for Undifferentiated Embryonal Sarcoma of the Liver

Search GEO for disease gene expression data for Undifferentiated Embryonal Sarcoma of the Liver.

Pathways for Undifferentiated Embryonal Sarcoma of the Liver

Pathways related to Undifferentiated Embryonal Sarcoma of the Liver according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.29 CDK4 MYOD1
2 11.23 CDK4 MDM2
3
Show member pathways
11.09 MYOD1 MYOG
4 11 MDM2 MYOD1
5 10.82 CDK4 MDM2
6 10.6 CDK4 MDM2
7 10.13 CDK4 MDM2

GO Terms for Undifferentiated Embryonal Sarcoma of the Liver

Cellular components related to Undifferentiated Embryonal Sarcoma of the Liver according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 transcription factor complex GO:0005667 8.8 CDK4 MYOD1 MYOG

Biological processes related to Undifferentiated Embryonal Sarcoma of the Liver according to GeneCards Suite gene sharing:

(show all 15)
id Name GO ID Score Top Affiliating Genes
1 cellular response to growth factor stimulus GO:0071363 9.55 MDM2 MYOG
2 skeletal muscle tissue development GO:0007519 9.54 MYOD1 MYOG
3 skeletal muscle cell differentiation GO:0035914 9.52 MYOD1 MYOG
4 positive regulation of cell cycle GO:0045787 9.51 CDK4 MDM2
5 cellular response to estradiol stimulus GO:0071392 9.49 MYOD1 MYOG
6 skeletal muscle fiber development GO:0048741 9.48 MYOD1 MYOG
7 positive regulation of muscle cell differentiation GO:0051149 9.46 MYOD1 MYOG
8 positive regulation of myoblast differentiation GO:0045663 9.43 MYOD1 MYOG
9 negative regulation of cell cycle arrest GO:0071157 9.4 CDK4 MDM2
10 positive regulation of myoblast fusion GO:1901741 9.37 MYOD1 MYOG
11 myoblast differentiation GO:0045445 9.32 MYOD1 MYOG
12 myotube differentiation GO:0014902 9.26 MYOD1 MYOG
13 positive regulation of skeletal muscle fiber development GO:0048743 9.16 MYOD1 MYOG
14 muscle cell fate commitment GO:0042693 8.96 MYOD1 MYOG
15 regulation of gene expression GO:0010468 8.92 CDK4 MDM2 MYOD1 PEG3

Molecular functions related to Undifferentiated Embryonal Sarcoma of the Liver according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding GO:0003705 9.26 MYOD1 MYOG
2 core promoter binding GO:0001047 9.16 MYOD1 MYOG
3 chromatin DNA binding GO:0031490 8.96 MYOD1 MYOG
4 E-box binding GO:0070888 8.62 MYOD1 MYOG

Sources for Undifferentiated Embryonal Sarcoma of the Liver

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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