MCID: UND001
MIFTS: 38

Undifferentiated Embryonal Sarcoma of the Liver malady

Liver diseases, Cancer diseases, Rare diseases categories

Aliases & Classifications for Undifferentiated Embryonal Sarcoma of the Liver

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Aliases & Descriptions for Undifferentiated Embryonal Sarcoma of the Liver:

Name: Undifferentiated Embryonal Sarcoma of the Liver 48
Undifferentiated Sarcoma of the Liver 48
Embryonal Sarcoma of the Liver 48
 
Undifferentiated Sarcoma 61
Ues 48


Classifications:



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Orphanet48 178315

Summaries for Undifferentiated Embryonal Sarcoma of the Liver

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MalaCards based summary: Undifferentiated Embryonal Sarcoma of the Liver, also known as undifferentiated sarcoma of the liver, is related to sarcoma and rhabdomyosarcoma. An important gene associated with Undifferentiated Embryonal Sarcoma of the Liver is CDK4 (cyclin-dependent kinase 4), and among its related pathways are Akt Signaling Pathway and Chronic myeloid leukemia. The compounds roscovitine and fludarabine have been mentioned in the context of this disorder. Affiliated tissues include liver, lung and brain, and related mouse phenotypes are tumorigenesis and muscle.

Related Diseases for Undifferentiated Embryonal Sarcoma of the Liver

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Diseases related to Undifferentiated Embryonal Sarcoma of the Liver via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 55)
idRelated DiseaseScoreTop Affiliating Genes
1sarcoma31.7CDK4, MDM2, MYOD1, MYOG
2rhabdomyosarcoma30.3MDM2, MYOD1, MYOG, CDK4
3embryonal sarcoma11.4
4hepatitis10.6
5systemic lupus erythematosus10.4
6appendicitis10.4
7fibrous histiocytoma10.4
8eosinophilia10.4
9hepatoblastoma10.4
10histiocytoma10.4
11lupus erythematosus10.4
12angiosarcoma10.3
13hellp syndrome10.3
14malignant mesenchymoma10.3MYOD1, MYOG
15alveolar soft-part sarcoma10.3MYOG, MYOD1
16myotonic dystrophy10.2MYOD1, MYOG
17laryngitis10.2
18malignant peripheral nerve sheath tumor10.2MDM2, MYOG
19neuropathy10.2MYOG, MYOD1
20embryonal cancer10.2MYOD1, MYOG
21connective tissue benign neoplasm10.1CDK4, MDM2
22dedifferentiated liposarcoma10.1MDM2, CDK4
23myxoid liposarcoma10.1CDK4, MDM2
24anaplastic oligodendroglioma10.1CDK4, MDM2
25lipoma10.1CDK4, MDM2
26liposarcoma10.1CDK4, MDM2
27uveal melanoma10.1MDM2, CDK4
28wilms tumor10.1MYOD1, MYOG
29grade iii astrocytoma10.1MDM2, CDK4
30acute lymphoblastic leukemia, childhood10.1MDM2, CDK4
31oligodendroglioma10.1MDM2, CDK4
32esophageal cancer10.1CDK4, MDM2
33oral cancer10.1MDM2, CDK4
34nasopharyngeal carcinoma10.1CDK4, MDM2
35polycystic kidney disease10.1
36kidney disease10.1
37chondrosarcoma10.1CDK4, MDM2
38embryonal rhabdomyosarcoma10.0CDK4, MYOD1, MYOG
39mesothelioma10.0MYOD1, MYOG, CDK4
40glioblastoma multiforme10.0CDK4, MDM2
41burkitt lymphoma10.0MDM2, CDK4
42ewing sarcoma10.0MYOG, MYOD1, MDM2
43lung cancer10.0MDM2, CDK4
44chronic lymphocytic leukemia10.0CDK4, MDM2
45osteosarcoma, somatic9.9MYOD1, MDM2, CDK4
46adenocarcinoma9.9CDK4, MDM2
47colorectal cancer9.9MYOD1, CDK4, MDM2
48lung benign neoplasm9.8CDK4, MDM2
49rhabdomyosarcoma 2, alveolar9.8MYOG, CDK4, MDM2, MYOD1
50malignant fibroxanthoma9.8CDK4, MDM2, MYOG, MYOD1

Graphical network of the top 20 diseases related to Undifferentiated Embryonal Sarcoma of the Liver:



Diseases related to undifferentiated embryonal sarcoma of the liver

Symptoms for Undifferentiated Embryonal Sarcoma of the Liver

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Drugs & Therapeutics for Undifferentiated Embryonal Sarcoma of the Liver

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Drug clinical trials:

Search ClinicalTrials for Undifferentiated Embryonal Sarcoma of the Liver

Search NIH Clinical Center for Undifferentiated Embryonal Sarcoma of the Liver

Genetic Tests for Undifferentiated Embryonal Sarcoma of the Liver

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Anatomical Context for Undifferentiated Embryonal Sarcoma of the Liver

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MalaCards organs/tissues related to Undifferentiated Embryonal Sarcoma of the Liver:

31
Liver, Lung, Brain, Heart, Adrenal gland

Animal Models for Undifferentiated Embryonal Sarcoma of the Liver or affiliated genes

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MGI Mouse Phenotypes related to Undifferentiated Embryonal Sarcoma of the Liver:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.0CDK4, MDM2, MYOD1
2MP:00053698.5CDK4, MDM2, MYOG, MYOD1
3MP:00028738.3MYOD1, MYOG, MALAT1, MDM2
4MP:00053787.6PEG3, MYOD1, MYOG, MDM2, CDK4
5MP:00107687.3PEG3, MYOD1, MYOG, MDM2, CDK4

Publications for Undifferentiated Embryonal Sarcoma of the Liver

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Articles related to Undifferentiated Embryonal Sarcoma of the Liver:

(show top 50)    (show all 76)
idTitleAuthorsYear
1
Undifferentiated embryonal sarcoma of the liver: a concise review. (25611111)
2015
2
Undifferentiated embryonal sarcoma of the liver mistaken for hepatic abscess in an adult. (25120683)
2014
3
Primary undifferentiated embryonal sarcoma of the liver misdiagnosed as hydatid cyst in a child: a case report and review of the literature. (25603636)
2014
4
Diagnosis and therapy of primary undifferentiated embryonal sarcoma of the liver. (24762610)
2014
5
A case of an undifferentiated embryonal sarcoma of the liver mimicking a liver abscess. (25364566)
2014
6
Management of undifferentiated embryonal sarcoma of the liver in children: a case series and management review. (24079623)
2013
7
Treatment of undifferentiated embryonal sarcoma of the liver in children--single center experience. (24210186)
2013
8
Undifferentiated embryonal sarcoma of the liver with focal osteoid picture-a case report. (24054758)
2013
9
Undifferentiated embryonal sarcoma of the liver in a middle-aged adult with systemic lupus erythematosus. (24073982)
2013
10
Molecular cytogenetic characterization of undifferentiated embryonal sarcoma of the liver: a case report and literature review. (22551002)
2012
11
Rare case of adult undifferentiated (embryonal) sarcoma of the liver treated with liver transplantation: excellent long-term survival. (25374706)
2012
12
Radiologic-pathologic comparison of undifferentiated embryonal sarcoma of the liver in a 61-year-old woman. (22421287)
2012
13
Undifferentiated embryonal sarcoma of the liver presenting as a hemorrhagic cystic tumor in an adult. (22146632)
2011
14
Paradoxical hepatic tumor: Undifferentiated embryonal sarcoma of the liver. (20352000)
2010
15
Diffuse membranous immunoreactivity of CD56 and paranuclear dot-like staining pattern of cytokeratins AE1/3, CAM5.2, and OSCAR in undifferentiated (embryonal) sarcoma of the liver. (19809302)
2010
16
Adult primary undifferentiated embryonal sarcoma of the liver: a case report. (20137381)
2010
17
Fine needle aspiration cytology of undifferentiated embryonal sarcoma of the liver. (20105209)
2010
18
Primary undifferentiated embryonal sarcoma of the liver mistaken for hydatid disease. (20615265)
2010
19
Resection of a large, ruptured, undifferentiated (embryonal) sarcoma of the liver in a child: a case report and review of the literature. (19278169)
2009
20
F-18 FDG PET/CT findings in a case of undifferentiated embryonal sarcoma of the liver with lung and adrenal gland metastasis in a child. (19352266)
2009
21
Undifferentiated (embryonal) sarcoma of the liver: an intriguing diagnosis in a child. (19242910)
2009
22
Undifferentiated embryonal sarcoma of the liver: case report and literature survey. (18836810)
2008
23
Undifferentiated embryonal sarcoma of the liver in adults. (18361435)
2008
24
Undifferentiated embryonal sarcoma of the liver in a child complicated by haemorrhage. (18688607)
2008
25
Management of undifferentiated embryonal sarcoma of the liver in pregnancy. (17267894)
2007
26
Non-random p53 mutations in pediatric undifferentiated (embryonal) sarcoma of the liver. (16757210)
2006
27
A 51-year-old woman with a liver mass. Undifferentiated embryonal sarcoma of the liver. (16454576)
2006
28
Improved survival with surgery and systemic chemotherapy for undifferentiated embryonal sarcoma of the liver. (16259353)
2005
29
Undifferentiated (embryonal) sarcoma of the liver (USL): MRI findings including dynamic gadolinium enhancement. (15234460)
2004
30
Undifferentiated (embryonal) sarcoma of the liver: case report and review of the literature. (19861818)
2003
31
Comparative genomic hybridization detects multiple chromosomal amplifications and deletions in undifferentiated embryonal sarcoma of the liver. (11376805)
2001
32
Undifferentiated embryonal sarcoma of the liver: results of clinical management in one center. (10591560)
1999
33
Hepatoblastomas and undifferentiated (embryonal) sarcoma of the liver: updating references while revising galley proofs. (9568154)
1998
34
Undifferentiated (embryonal) sarcoma of the liver: fine-needle aspiration cytology and preoperative chemotherapy as an approach to diagnosis and initial treatment. A case report. (9702485)
1998
35
Undifferentiated (embryonal) sarcoma of the liver: pathologic basis of imaging findings in 28 cases. (9169704)
1997
36
Fine needle aspiration cytology of undifferentiated (embryonal) sarcoma of the liver. A case report. (9990257)
1997
37
Undifferentiated embryonal sarcoma of the liver in childhood. (8772820)
1995
38
Undifferentiated embryonal sarcoma of the liver treated with chemotherapy: CT imaging in four patients. (7787716)
1995
39
Undifferentiated (embryonal) sarcoma of the liver in adults. (7893087)
1995
40
Cytopathology of undifferentiated (embryonal) sarcoma of the liver. (7587875)
1995
41
Undifferentiated (embryonal) sarcoma of the liver in an adult patient with metastasis of the heart and brain. (8012163)
1994
42
Undifferentiated (embryonal) sarcoma of the liver in childhood. Successful combined-modality therapy in four patients. (8402469)
1993
43
Undifferentiated (embryonal) sarcoma of the liver. Pathologic findings and long-term survival after complete surgical resection. (1727675)
1992
44
Undifferentiated (embryonal) sarcoma of the liver. A tumor of uncertain histogenesis showing divergent differentiation. (1711792)
1991
45
Undifferentiated (embryonal) sarcoma of the liver: ultrastructure, immunohistochemistry, and DNA ploidy analysis of two cases. (2371180)
1990
46
Undifferentiated (embryonal) sarcoma of the liver. Epithelial features as shown by immunohistochemical analysis and electron microscopic examination. (2680050)
1989
47
Undifferentiated (embryonal) sarcoma of the liver in childhood: report of two cases. (4009092)
1985
48
Undifferentiated (embryonal) sarcoma of the liver with alpha-1-antitrypsin deposits: immunohistochemical and ultrastructural studies. (6992971)
1980
49
Undifferentiated (embryonal) sarcoma of the liver. (7395519)
1980
50
Undifferentiated (embryonal) sarcoma of the liver: report of 31 cases. (208754)
1978

Variations for Undifferentiated Embryonal Sarcoma of the Liver

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Expression for genes affiliated with Undifferentiated Embryonal Sarcoma of the Liver

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Search GEO for disease gene expression data for Undifferentiated Embryonal Sarcoma of the Liver.

Pathways for genes affiliated with Undifferentiated Embryonal Sarcoma of the Liver

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Pathways related to Undifferentiated Embryonal Sarcoma of the Liver according to GeneCards Suite gene sharing:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6CDK4, MDM2
2
Show member pathways
9.6MDM2, CDK4
39.6CDK4, MDM2
4
Show member pathways
DNA damage response36
9.6CDK4, MDM2
5
Show member pathways
Prostate Cancer36
Integrated Cancer pathway36
Steroid Biosynthesis36
9.6CDK4, MDM2
69.6CDK4, MDM2
79.6CDK4, MDM2
89.6MDM2, CDK4
9
Show member pathways
Cell cycle36
9.6CDK4, MDM2
10
Show member pathways
9.6CDK4, MDM2
119.6CDK4, MDM2
129.4MYOD1, CDK4
139.4MDM2, MYOD1
149.3MYOD1, MYOG
15
Show member pathways
9.3MYOG, MYOD1
16
Show member pathways
Development Role of HDAC and calcium calmodulin dependent kinase CaMK in control of skeletal myogenesis59
9.3MYOD1, MYOG
17
Show member pathways
8.9CDK4, MYOG, MYOD1

Compounds for genes affiliated with Undifferentiated Embryonal Sarcoma of the Liver

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Compounds related to Undifferentiated Embryonal Sarcoma of the Liver according to GeneCards Suite gene sharing:

(show all 42)
idCompoundScoreTop Affiliating Genes
1roscovitine4410.0MDM2, CDK4
2fludarabine44 50 1112.0CDK4, MDM2
3benzo(a)pyrene4410.0CDK4, MDM2
4flavopiridol44 1110.9MDM2, CDK4
5trastuzumab44 50 1111.9CDK4, MDM2
6gefitinib44 50 1111.9MDM2, CDK4
7carboplatin44 50 1111.9CDK4, MDM2
8adpribose449.9CDK4, MDM2
9sp 60012544 6010.9MDM2, CDK4
10lead449.9CDK4, MDM2
11thymidylate449.8CDK4, MDM2
12resveratrol44 60 24 1112.7MDM2, CDK4
13camptothecin44 60 1111.5CDK4, MDM2
14rapamycin449.5MDM2, CDK4, MYOG
15pd 98,059449.5CDK4, MDM2, MYOG
16ly294002449.5MDM2, CDK4, MYOG
17tgf beta1449.4MYOD1, CDK4
18geldanamycin44 50 60 1112.4CDK4, MDM2, MYOD1
19lactacystin449.4MDM2, MYOD1, CDK4
20bromodeoxyuridine449.3MYOD1, MYOG, CDK4
21cyclic amp44 2410.3MYOD1, CDK4, MDM2
2212-o-tetradecanoylphorbol 13-acetate449.3MYOG, CDK4, MYOD1
23butyrate449.3MYOG, CDK4, MYOD1
24nitric oxide44 24 1111.3CDK4, MDM2, MYOG
25arginine449.2MYOD1, CDK4, MDM2
26phosphatidylinositol449.2MDM2, CDK4, MYOD1
27threonine449.1CDK4, MDM2, MYOD1
28mg 13244 6010.1MDM2, MYOD1
29alanine449.0MDM2, MYOD1, CDK4
305-aza-2deoxycytidine449.0PEG3, MYOD1, MDM2
31paraffin448.9MDM2, MYOG, CDK4, MYOD1
32testosterone44 60 24 1111.9MYOD1, MYOG, MDM2, CDK4
33steroid448.9MYOG, CDK4, MYOD1, MDM2
34oligonucleotide448.9CDK4, MYOD1, MYOG, MDM2
35oxygen44 249.9MYOD1, MYOG, MDM2, CDK4
36estrogen448.9MYOG, MDM2, MYOD1, CDK4
37cysteine448.9MDM2, MYOG, CDK4, MYOD1
38serine448.8MYOD1, MDM2, MYOG, CDK4
39tyrosine448.8MDM2, MYOG, CDK4, MYOD1
40calcium44 50 24 1111.6CDK4, MDM2, MYOD1, MYOG
41zinc44 249.6CDK4, PEG3, MYOD1, MDM2
42vegf448.1CDK4, MDM2, MYOG, MYOD1, PEG3

GO Terms for genes affiliated with Undifferentiated Embryonal Sarcoma of the Liver

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Cellular components related to Undifferentiated Embryonal Sarcoma of the Liver according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1transcription factor complexGO:00056678.8CDK4, MYOG, MYOD1
2nucleoplasmGO:00056548.2MYOD1, MYOG, MDM2, CDK4
3nucleusGO:00056347.6CDK4, MDM2, MYOG, MYOD1, PEG3

Biological processes related to Undifferentiated Embryonal Sarcoma of the Liver according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of cell cycle arrestGO:00711579.7CDK4, MDM2
2muscle cell fate commitmentGO:00426939.5MYOG, MYOD1
3skeletal muscle fiber developmentGO:00487419.4MYOG, MYOD1
4cellular response to estradiol stimulusGO:00713929.3MYOD1, MYOG
5skeletal muscle tissue developmentGO:00075199.3MYOG, MYOD1
6positive regulation of muscle cell differentiationGO:00511499.2MYOG, MYOD1
7muscle cell differentiationGO:00426929.0MYOG, MYOD1

Molecular functions related to Undifferentiated Embryonal Sarcoma of the Liver according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1core promoter bindingGO:00010479.3MYOG, MYOD1
2chromatin DNA bindingGO:00314909.2MYOG, MYOD1
3E-box bindingGO:00708889.0MYOG, MYOD1

Sources for Undifferentiated Embryonal Sarcoma of the Liver

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet