UES
MCID: UND001
MIFTS: 44

Undifferentiated Embryonal Sarcoma of the Liver (UES) malady

Liver diseases, Cancer diseases, Rare diseases categories
Download this MalaCard

Summaries for Undifferentiated Embryonal Sarcoma of the Liver

About this section


Fully expand this MalaCard
MalaCards based summary: Undifferentiated Embryonal Sarcoma of the Liver, also known as UES, is related to sarcoma and rhabdomyosarcoma. An important gene associated with Undifferentiated Embryonal Sarcoma of the Liver is CDK4 (cyclin-dependent kinase 4), and among its related pathways are Akt Signaling Pathway and Chronic myeloid leukemia. The compounds roscovitine and benzo(a)pyrene have been mentioned in the context of this disorder. Affiliated tissues include liver, lung and brain, and related mouse phenotypes are tumorigenesis and muscle.

Aliases & Classifications for Undifferentiated Embryonal Sarcoma of the Liver

About this section

Undifferentiated Embryonal Sarcoma of the Liver, Aliases & Descriptions:

Name: Undifferentiated Embryonal Sarcoma of the Liver 48
Ues 48 62
 
Undifferentiated Sarcoma of the Liver 48
Embryonal Sarcoma of the Liver 48


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Anatomical: Liver diseases


Related Diseases for Undifferentiated Embryonal Sarcoma of the Liver

About this section

Diseases related to Undifferentiated Embryonal Sarcoma of the Liver via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 54)
idRelated DiseaseScoreTop Affiliating Genes
1sarcoma31.7CDK4, MDM2, MYOD1, MYOG
2rhabdomyosarcoma30.3MDM2, MYOD1, MYOG, CDK4
3embryonal sarcoma11.3
4hepatitis10.6
5systemic lupus erythematosus10.4
6fibrous histiocytoma10.4
7appendicitis10.4
8eosinophilia10.4
9hepatoblastoma10.4
10histiocytoma10.4
11lupus erythematosus10.4
12angiosarcoma10.3
13hellp syndrome10.3
14malignant mesenchymoma10.3MYOD1, MYOG
15alveolar soft part sarcoma10.3MYOG, MYOD1
16myotonic dystrophy10.2MYOD1, MYOG
17laryngitis10.2
18malignant peripheral nerve sheath tumor10.2MDM2, MYOG
19neuropathy10.2MYOG, MYOD1
20embryonal cancer10.2MYOD1, MYOG
21dedifferentiated liposarcoma10.1MDM2, CDK4
22myxoid liposarcoma10.1CDK4, MDM2
23anaplastic oligodendroglioma10.1CDK4, MDM2
24lipoma10.1CDK4, MDM2
25liposarcoma10.1CDK4, MDM2
26uveal melanoma10.1MDM2, CDK4
27wilms tumor10.1MYOD1, MYOG
28grade iii astrocytoma10.1MDM2, CDK4
29acute lymphoblastic leukemia, childhood10.1MDM2, CDK4
30oligodendroglioma10.1MDM2, CDK4
31esophageal cancer10.1CDK4, MDM2
32oral cancer10.1MDM2, CDK4
33nasopharynx carcinoma10.1CDK4, MDM2
34chondrosarcoma10.1CDK4, MDM2
35polycystic kidney disease10.1
36kidney disease10.1
37embryonal rhabdomyosarcoma10.0CDK4, MYOD1, MYOG
38malignant mesothelioma10.0MYOD1, MYOG, CDK4
39glioblastoma multiforme10.0CDK4, MDM2
40burkitt's lymphoma10.0MDM2, CDK4
41peripheral primitive neuroectodermal tumor10.0MYOG, MYOD1, MDM2
42non-small cell lung carcinoma10.0MDM2, CDK4
43chronic lymphocytic leukemia10.0CDK4, MDM2
44osteosarcoma9.9MYOD1, MDM2, CDK4
45adenocarcinoma9.9CDK4, MDM2
46colonic benign neoplasm9.9MYOD1, CDK4, MDM2
47lung benign neoplasm9.8CDK4, MDM2
48alveolar rhabdomyosarcoma9.8MYOG, CDK4, MDM2, MYOD1
49malignant fibroxanthoma9.8CDK4, MDM2, MYOG, MYOD1
50leiomyosarcoma9.8CDK4, MYOG, MDM2, MYOD1

Graphical network of the top 20 diseases related to Undifferentiated Embryonal Sarcoma of the Liver:



Diseases related to undifferentiated embryonal sarcoma of the liver

Symptoms for Undifferentiated Embryonal Sarcoma of the Liver

About this section

Drugs & Therapeutics for Undifferentiated Embryonal Sarcoma of the Liver

About this section

Drug clinical trials:

Search ClinicalTrials for Undifferentiated Embryonal Sarcoma of the Liver

Search NIH Clinical Center for Undifferentiated Embryonal Sarcoma of the Liver

Genetic Tests for Undifferentiated Embryonal Sarcoma of the Liver

About this section

Anatomical Context for Undifferentiated Embryonal Sarcoma of the Liver

About this section

MalaCards organs/tissues related to Undifferentiated Embryonal Sarcoma of the Liver:

32
Liver, Lung, Brain, Heart, Smooth muscle, Adrenal gland

Animal Models for Undifferentiated Embryonal Sarcoma of the Liver or affiliated genes

About this section

MGI Mouse Phenotypes related to Undifferentiated Embryonal Sarcoma of the Liver:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.0CDK4, MDM2, MYOD1
2MP:00053698.5CDK4, MDM2, MYOG, MYOD1
3MP:00028738.3MYOD1, MYOG, MALAT1, MDM2
4MP:00053787.6PEG3, MYOD1, MYOG, MDM2, CDK4
5MP:00107687.3PEG3, MYOD1, MYOG, MDM2, CDK4

Publications for Undifferentiated Embryonal Sarcoma of the Liver

About this section

Articles related to Undifferentiated Embryonal Sarcoma of the Liver:

(show top 50)    (show all 75)
idTitleAuthorsYear
1
Undifferentiated embryonal sarcoma of the liver mistaken for hepatic abscess in an adult. (25120683)
2014
2
Diagnosis and therapy of primary undifferentiated embryonal sarcoma of the liver. (24762610)
2014
3
A case of an undifferentiated embryonal sarcoma of the liver mimicking a liver abscess. (25364566)
2014
4
Management of undifferentiated embryonal sarcoma of the liver in children: a case series and management review. (24079623)
2013
5
Treatment of undifferentiated embryonal sarcoma of the liver in children--single center experience. (24210186)
2013
6
Undifferentiated embryonal sarcoma of the liver with focal osteoid picture-a case report. (24054758)
2013
7
Undifferentiated embryonal sarcoma of the liver in a middle-aged adult with systemic lupus erythematosus. (24073982)
2013
8
Molecular cytogenetic characterization of undifferentiated embryonal sarcoma of the liver: a case report and literature review. (22551002)
2012
9
Rare case of adult undifferentiated (embryonal) sarcoma of the liver treated with liver transplantation: excellent long-term survival. (25374706)
2012
10
Radiologic-pathologic comparison of undifferentiated embryonal sarcoma of the liver in a 61-year-old woman. (22421287)
2012
11
Undifferentiated embryonal sarcoma of the liver presenting as a hemorrhagic cystic tumor in an adult. (22146632)
2011
12
Undifferentiated embryonal sarcoma of the liver is associated with mesenchymal hamartoma and multiple chromosomal abnormalities: a review of eleven cases. (20925497)
2011
13
Paradoxical hepatic tumor: Undifferentiated embryonal sarcoma of the liver. (20352000)
2010
14
Diffuse membranous immunoreactivity of CD56 and paranuclear dot-like staining pattern of cytokeratins AE1/3, CAM5.2, and OSCAR in undifferentiated (embryonal) sarcoma of the liver. (19809302)
2010
15
Adult primary undifferentiated embryonal sarcoma of the liver: a case report. (20137381)
2010
16
Fine needle aspiration cytology of undifferentiated embryonal sarcoma of the liver. (20105209)
2010
17
Primary undifferentiated embryonal sarcoma of the liver mistaken for hydatid disease. (20615265)
2010
18
Resection of a large, ruptured, undifferentiated (embryonal) sarcoma of the liver in a child: a case report and review of the literature. (19278169)
2009
19
F-18 FDG PET/CT findings in a case of undifferentiated embryonal sarcoma of the liver with lung and adrenal gland metastasis in a child. (19352266)
2009
20
Undifferentiated (embryonal) sarcoma of the liver: an intriguing diagnosis in a child. (19242910)
2009
21
Undifferentiated embryonal sarcoma of the liver: case report and literature survey. (18836810)
2008
22
Undifferentiated embryonal sarcoma of the liver in adults. (18361435)
2008
23
Undifferentiated embryonal sarcoma of the liver in a child complicated by haemorrhage. (18688607)
2008
24
Management of undifferentiated embryonal sarcoma of the liver in pregnancy. (17267894)
2007
25
Non-random p53 mutations in pediatric undifferentiated (embryonal) sarcoma of the liver. (16757210)
2006
26
A 51-year-old woman with a liver mass. Undifferentiated embryonal sarcoma of the liver. (16454576)
2006
27
Improved survival with surgery and systemic chemotherapy for undifferentiated embryonal sarcoma of the liver. (16259353)
2005
28
Undifferentiated (embryonal) sarcoma of the liver (USL): MRI findings including dynamic gadolinium enhancement. (15234460)
2004
29
Undifferentiated (embryonal) sarcoma of the liver in middle-aged adults: smooth muscle differentiation determined by immunohistochemistry and electron microscopy. (12673559)
2003
30
Undifferentiated (embryonal) sarcoma of the liver: case report and review of the literature. (19861818)
2003
31
Comparative genomic hybridization detects multiple chromosomal amplifications and deletions in undifferentiated embryonal sarcoma of the liver. (11376805)
2001
32
Undifferentiated embryonal sarcoma of the liver: results of clinical management in one center. (10591560)
1999
33
Hepatoblastomas and undifferentiated (embryonal) sarcoma of the liver: updating references while revising galley proofs. (9568154)
1998
34
Undifferentiated (embryonal) sarcoma of the liver: fine-needle aspiration cytology and preoperative chemotherapy as an approach to diagnosis and initial treatment. A case report. (9702485)
1998
35
Undifferentiated (embryonal) sarcoma of the liver: pathologic basis of imaging findings in 28 cases. (9169704)
1997
36
Fine needle aspiration cytology of undifferentiated (embryonal) sarcoma of the liver. A case report. (9990257)
1997
37
Undifferentiated embryonal sarcoma of the liver in childhood. (8772820)
1995
38
Undifferentiated embryonal sarcoma of the liver treated with chemotherapy: CT imaging in four patients. (7787716)
1995
39
Undifferentiated (embryonal) sarcoma of the liver in adults. (7893087)
1995
40
Cytopathology of undifferentiated (embryonal) sarcoma of the liver. (7587875)
1995
41
Undifferentiated (embryonal) sarcoma of the liver in an adult patient with metastasis of the heart and brain. (8012163)
1994
42
Undifferentiated (embryonal) sarcoma of the liver in childhood. Successful combined-modality therapy in four patients. (8402469)
1993
43
Undifferentiated (embryonal) sarcoma of the liver. Pathologic findings and long-term survival after complete surgical resection. (1727675)
1992
44
Undifferentiated (embryonal) sarcoma of the liver. A tumor of uncertain histogenesis showing divergent differentiation. (1711792)
1991
45
Undifferentiated (embryonal) sarcoma of the liver: ultrastructure, immunohistochemistry, and DNA ploidy analysis of two cases. (2371180)
1990
46
Undifferentiated (embryonal) sarcoma of the liver. Epithelial features as shown by immunohistochemical analysis and electron microscopic examination. (2680050)
1989
47
Undifferentiated (embryonal) sarcoma of the liver in childhood: report of two cases. (4009092)
1985
48
Undifferentiated (embryonal) sarcoma of the liver with alpha-1-antitrypsin deposits: immunohistochemical and ultrastructural studies. (6992971)
1980
49
Undifferentiated (embryonal) sarcoma of the liver. (7395519)
1980
50
Undifferentiated (embryonal) sarcoma of the liver: report of 31 cases. (208754)
1978

Variations for Undifferentiated Embryonal Sarcoma of the Liver

About this section

Expression for genes affiliated with Undifferentiated Embryonal Sarcoma of the Liver

About this section
Expression patterns in normal tissues for genes affiliated with Undifferentiated Embryonal Sarcoma of the Liver

Search GEO for disease gene expression data for Undifferentiated Embryonal Sarcoma of the Liver.

Pathways for genes affiliated with Undifferentiated Embryonal Sarcoma of the Liver

About this section

Pathways related to Undifferentiated Embryonal Sarcoma of the Liver according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6CDK4, MDM2
2
Show member pathways
9.6MDM2, CDK4
39.6CDK4, MDM2
4
Show member pathways
DNA damage response37
9.6CDK4, MDM2
5
Show member pathways
Prostate Cancer37
Integrated Cancer pathway37
Steroid Biosynthesis37
9.6CDK4, MDM2
69.6CDK4, MDM2
79.6CDK4, MDM2
89.6MDM2, CDK4
9
Show member pathways
Cell cycle37
9.6CDK4, MDM2
10
Show member pathways
9.6CDK4, MDM2
119.6CDK4, MDM2
129.4MYOD1, CDK4
139.4MDM2, MYOD1
149.3MYOD1, MYOG
15
Show member pathways
9.3MYOG, MYOD1
16
Show member pathways
Development Role of HDAC and calcium calmodulin dependent kinase CaMK in control of skeletal myogenesis60
9.3MYOD1, MYOG
17
Show member pathways
8.9CDK4, MYOG, MYOD1

Compounds for genes affiliated with Undifferentiated Embryonal Sarcoma of the Liver

About this section

Compounds related to Undifferentiated Embryonal Sarcoma of the Liver according to GeneCards/GeneDecks:

(show all 42)
idCompoundScoreTop Affiliating Genes
1roscovitine4410.0CDK4, MDM2
2benzo(a)pyrene4410.0CDK4, MDM2
3fludarabine44 50 1112.0CDK4, MDM2
4flavopiridol44 1110.9CDK4, MDM2
5trastuzumab44 50 1111.9MDM2, CDK4
6gefitinib44 50 1111.9MDM2, CDK4
7carboplatin44 50 1111.9CDK4, MDM2
8adpribose449.9CDK4, MDM2
9sp 60012544 6110.9CDK4, MDM2
10lead449.9MDM2, CDK4
11thymidylate449.8MDM2, CDK4
12resveratrol44 61 24 1112.7CDK4, MDM2
13camptothecin44 61 1111.5CDK4, MDM2
14rapamycin449.5CDK4, MDM2, MYOG
15pd 98,059449.5CDK4, MDM2, MYOG
16ly294002449.5MYOG, MDM2, CDK4
17tgf beta1449.4CDK4, MYOD1
18geldanamycin44 50 61 1112.4CDK4, MDM2, MYOD1
19lactacystin449.4MYOD1, MDM2, CDK4
20bromodeoxyuridine449.3CDK4, MYOG, MYOD1
21cyclic amp44 2410.3MYOD1, MDM2, CDK4
2212-o-tetradecanoylphorbol 13-acetate449.3CDK4, MYOG, MYOD1
23butyrate449.3MYOD1, MYOG, CDK4
24nitric oxide44 24 1111.3CDK4, MDM2, MYOG
25arginine449.2CDK4, MDM2, MYOD1
26phosphatidylinositol449.2MYOD1, MDM2, CDK4
27threonine449.1MYOD1, MDM2, CDK4
28mg 13244 6110.1MDM2, MYOD1
29alanine449.0MYOD1, MDM2, CDK4
305-aza-2deoxycytidine449.0PEG3, MYOD1, MDM2
31paraffin448.9MYOD1, MYOG, MDM2, CDK4
32testosterone44 61 24 1111.9MYOD1, MYOG, MDM2, CDK4
33steroid448.9MYOD1, MYOG, MDM2, CDK4
34oligonucleotide448.9CDK4, MDM2, MYOG, MYOD1
35oxygen44 249.9MYOD1, MYOG, MDM2, CDK4
36estrogen448.9CDK4, MDM2, MYOG, MYOD1
37cysteine448.9MYOD1, MYOG, MDM2, CDK4
38serine448.8MYOD1, MYOG, MDM2, CDK4
39tyrosine448.8CDK4, MDM2, MYOG, MYOD1
40calcium44 50 24 1111.6MYOD1, MYOG, MDM2, CDK4
41zinc44 249.6CDK4, MDM2, MYOD1, PEG3
42vegf448.1CDK4, MDM2, MYOG, MYOD1, PEG3

GO Terms for genes affiliated with Undifferentiated Embryonal Sarcoma of the Liver

About this section

Cellular components related to Undifferentiated Embryonal Sarcoma of the Liver according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transcription factor complexGO:0056678.8CDK4, MYOG, MYOD1
2nucleoplasmGO:0056548.2MYOD1, MYOG, MDM2, CDK4
3nucleusGO:0056347.6CDK4, MDM2, MYOG, MYOD1, PEG3

Biological processes related to Undifferentiated Embryonal Sarcoma of the Liver according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of cell cycle arrestGO:0711579.7CDK4, MDM2
2muscle cell fate commitmentGO:0426939.5MYOG, MYOD1
3skeletal muscle fiber developmentGO:0487419.4MYOG, MYOD1
4cellular response to estradiol stimulusGO:0713929.3MYOD1, MYOG
5skeletal muscle tissue developmentGO:0075199.3MYOG, MYOD1
6positive regulation of muscle cell differentiationGO:0511499.2MYOG, MYOD1
7muscle cell differentiationGO:0426929.0MYOG, MYOD1

Molecular functions related to Undifferentiated Embryonal Sarcoma of the Liver according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1core promoter bindingGO:0010479.3MYOG, MYOD1
2chromatin DNA bindingGO:0314909.2MYOG, MYOD1
3E-box bindingGO:0708889.0MYOG, MYOD1

Products for genes affiliated with Undifferentiated Embryonal Sarcoma of the Liver

About this section
  • Antibodies
  • Proteins
  • Lysates

Sources for Undifferentiated Embryonal Sarcoma of the Liver

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet