UES
MCID: UND001
MIFTS: 31

Undifferentiated Embryonal Sarcoma of the Liver (UES) malady

Liver diseases, Cancer diseases categories

Summaries for Undifferentiated Embryonal Sarcoma of the Liver

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MalaCards: Undifferentiated Embryonal Sarcoma of the Liver, also known as undifferentiated sarcoma of the liver, is related to sarcoma and embryonal rhabdomyosarcoma. An important gene associated with Undifferentiated Embryonal Sarcoma of the Liver is SERPINA3 (serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3), and among its related pathways are Regulation of nuclear SMAD2/3 signaling and Chronic myeloid leukemia. The compounds creatinine and fludarabine have been mentioned in the context of this disorder. Affiliated tissues include liver, and related mouse phenotype muscle.

Aliases & Classifications for Undifferentiated Embryonal Sarcoma of the Liver

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48Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Liver diseases


Aliases & Descriptions:

undifferentiated embryonal sarcoma of the liver 48
undifferentiated sarcoma of the liver 48
embryonal sarcoma of the liver 48
ues 48


Related Diseases for Undifferentiated Embryonal Sarcoma of the Liver

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17GeneCards, 18GeneDecks
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Diseases related to Undifferentiated Embryonal Sarcoma of the Liver via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 56)
idRelated DiseaseScoreTop Affiliating Genes
1sarcoma31.9CDK4, MYOG, MYOD1, MDM2
2embryonal rhabdomyosarcoma30.5CDK4, MYOG, MYOD1
3rhabdomyosarcoma30.5MDM2, MYOD1, MYOG, CDK4
4angiosarcoma30.3SERPINA3
5liver sarcoma11.3
6fibrous histiocytoma10.4
7systemic lupus erythematosus10.4
8liver rhabdomyosarcoma10.4
9brain sarcoma10.4
10appendicitis10.4
11eosinophilia10.4
12heart sarcoma10.4
13hepatitis10.4
14hepatoblastoma10.4
15histiocytoma10.4
16liver disease10.4
17lung sarcoma10.4
18lupus erythematosus10.4
19liver angiosarcoma10.2
20hellp syndrome10.2
21laryngitis10.2
22polycystic kidney disease10.0
23kidney disease10.0
24fibrosarcoma10.0MDM2
25alveolar soft part sarcoma10.0MYOD1
26rhabdoid tumor10.0MYOD1
27malignant mesothelioma10.0CDK4
28insulin resistance10.0MYOD1
29malignant peripheral nerve sheath tumor10.0MDM2, MYOG
30malignant mesenchymoma10.0MYOG, MYOD1
31wilms tumor10.0MYOG, MYOD1
32dedifferentiated liposarcoma10.0CDK4, MDM2
33myxoid liposarcoma10.0CDK4, MDM2
34anaplastic oligodendroglioma10.0CDK4, MDM2
35intraocular melanoma10.0CDK4, MDM2
36acute lymphoblastic leukemia, childhood10.0CDK4, MDM2
37esophageal cancer10.0MDM2, CDK4
38lipoma10.0CDK4, MDM2
39anaplastic astrocytoma10.0CDK4, MDM2
40nasopharynx carcinoma10.0CDK4, MDM2
41peripheral primitive neuroectodermal tumor10.0MDM2, MYOD1, MYOG
42chondrosarcoma10.0MDM2, CDK4, SERPINA3
43glioblastoma multiforme10.0MDM2, CDK4
44breast cancer10.0SERPINA3, CDK4, MDM2
45benign mesothelioma10.0CDK4, MYOG, MYOD1
46malignant glioma10.0SERPINA3, CDK4, MDM2
47osteosarcoma10.0MDM2, MYOD1, CDK4
48lung cancer10.0MDM2, CDK4, SERPINA3
49squamous cell carcinoma10.0SERPINA3, CDK4, MDM2
50burkitt's lymphoma10.0CDK4, MYOD1, MDM2

Graphical network of the top 20 diseases related to Undifferentiated Embryonal Sarcoma of the Liver:



Diseases related to undifferentiated embryonal sarcoma of the liver

Clinical Features for Undifferentiated Embryonal Sarcoma of the Liver

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Drugs & Therapeutics for Undifferentiated Embryonal Sarcoma of the Liver

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Undifferentiated Embryonal Sarcoma of the Liver

Drug clinical trials:

Search ClinicalTrials for Undifferentiated Embryonal Sarcoma of the Liver

Search NIH Clinical Center for Undifferentiated Embryonal Sarcoma of the Liver

Search CenterWatch for Undifferentiated Embryonal Sarcoma of the Liver

Genetic Tests for Undifferentiated Embryonal Sarcoma of the Liver

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Anatomical Context for Undifferentiated Embryonal Sarcoma of the Liver

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32MalaCards
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MalaCards organs/tissues related to Undifferentiated Embryonal Sarcoma of the Liver:

32
Liver

Animal Models for Undifferentiated Embryonal Sarcoma of the Liver or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Undifferentiated Embryonal Sarcoma of the Liver:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.8CDK4, MYOD1, MDM2

Publications for Undifferentiated Embryonal Sarcoma of the Liver

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Genetic Variations for Undifferentiated Embryonal Sarcoma of the Liver

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Expression for genes affiliated with Undifferentiated Embryonal Sarcoma of the Liver

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Undifferentiated Embryonal Sarcoma of the Liver

Search GEO for disease gene expression data for Undifferentiated Embryonal Sarcoma of the Liver.

Pathways for genes affiliated with Undifferentiated Embryonal Sarcoma of the Liver

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37NCBI BioSystems Database, 29KEGG, 55SinoBiological, 51QIAGEN, 12EMD Millipore, 52R&D Systems
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Compounds for genes affiliated with Undifferentiated Embryonal Sarcoma of the Liver

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44Novoseek, 11DrugBank, 49PharmGKB, 59Tocris Bioscience, 24HMDB, 28IUPHAR
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Compounds related to Undifferentiated Embryonal Sarcoma of the Liver according to GeneCards/GeneDecks:

(show all 45)
idCompoundScoreTop Affiliating Genes
1creatinine449.8SERPINA3, MYOD1
2fludarabine44 1110.6CDK4, MDM2
3roscovitine449.6MDM2, CDK4
4benzo(a)pyrene449.6CDK4, MDM2
5flavopiridol44 1110.6CDK4, MDM2
6trastuzumab44 49 1111.6MDM2, CDK4
7carboplatin44 49 1111.5MDM2, CDK4
8gefitinib44 49 1111.4MDM2, CDK4
9adpribose449.4CDK4, MDM2
10thymidylate449.3MDM2, CDK4
11valine449.3CDK4, MDM2, SERPINA3
12leucine449.2CDK4, SERPINA3, MYOD1
13geldanamycin44 49 59 1112.2MDM2, CDK4, MYOD1
14sp 60012544 5910.2MDM2, CDK4
15lactacystin449.2MYOD1, CDK4, MDM2
16estradiol44 11 2411.2SERPINA3, MDM2, CDK4
17iron44 2410.2SERPINA3, MDM2, CDK4
18progesterone44 59 28 11 2413.1MDM2, CDK4, SERPINA3
19lead449.0MDM2, CDK4
20cyclic amp44 2410.0MDM2, CDK4, MYOD1
21acetylcholine44 49 28 11 2413.0MYOG, MYOD1, SERPINA3
22bromodeoxyuridine449.0CDK4, MYOG, MYOD1
2312-o-tetradecanoylphorbol 13-acetate449.0MYOG, MYOD1, CDK4
24butyrate449.0CDK4, MYOG, MYOD1
25dexamethasone44 49 28 1111.9SERPINA3, MDM2, CDK4
26rapamycin448.9CDK4, MYOG, MDM2
27pd 98,059448.9MDM2, CDK4, MYOG
28ly294002448.8MDM2, MYOG, CDK4
29arginine448.8MDM2, MYOD1, CDK4, SERPINA3
30zinc44 249.8CDK4, SERPINA3, MYOD1, MDM2
31threonine448.7MDM2, MYOD1, CDK4, SERPINA3
32alanine448.7SERPINA3, CDK4, MYOD1, MDM2
33retinoic acid44 249.5MYOD1, MYOG, CDK4, SERPINA3
34glucose448.5CDK4, MYOG, MYOD1, SERPINA3
35testosterone44 59 11 2411.4MYOG, CDK4, MYOD1, MDM2
36vegf448.4CDK4, MYOG, MYOD1, MDM2
37tyrosine448.2MYOD1, MDM2, MYOG, CDK4
38paraffin448.0CDK4, SERPINA3, MYOD1, MYOG, MDM2
39steroid448.0SERPINA3, MYOD1, CDK4, MYOG, MDM2
40oligonucleotide448.0MDM2, SERPINA3, CDK4, MYOD1, MYOG
41oxygen44 249.0MDM2, MYOD1, MYOG, CDK4, SERPINA3
42estrogen448.0MDM2, MYOD1, MYOG, CDK4, SERPINA3
43cysteine448.0CDK4, SERPINA3, MYOD1, MYOG, MDM2
44serine447.9MDM2, MYOD1, MYOG, CDK4, SERPINA3
45calcium44 49 11 2410.9SERPINA3, CDK4, MYOD1, MDM2, MYOG

GO Terms for genes affiliated with Undifferentiated Embryonal Sarcoma of the Liver

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16Gene Ontology
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Cellular components related to Undifferentiated Embryonal Sarcoma of the Liver according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transcription factor complexGO:0056678.5MYOD1, MYOG, CDK4
2nucleoplasmGO:0056547.7MDM2, MYOD1, MYOG, CDK4
3nucleusGO:0056347.5MDM2, MYOD1, MYOG, CDK4, SERPINA3

Biological processes related to Undifferentiated Embryonal Sarcoma of the Liver according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1muscle cell fate commitmentGO:0426939.2MYOG, MYOD1
2skeletal muscle fiber developmentGO:0487419.2MYOG, MYOD1
3cellular response to estradiol stimulusGO:0713929.1MYOG, MYOD1
4skeletal muscle tissue developmentGO:0075199.1MYOD1, MYOG
5positive regulation of muscle cell differentiationGO:0511499.0MYOG, MYOD1
6muscle cell differentiationGO:0426928.8MYOD1, MYOG

Molecular functions related to Undifferentiated Embryonal Sarcoma of the Liver according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1E-box bindingGO:0708889.1MYOG, MYOD1
2chromatin DNA bindingGO:0314909.0MYOG, MYOD1
3core promoter bindingGO:0010478.8MYOG, MYOD1

Products for genes affiliated with Undifferentiated Embryonal Sarcoma of the Liver

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Undifferentiated Embryonal Sarcoma of the Liver

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet