MCID: UNX002

Unexplained Intellectual Disability malady

Category: Rare diseases

Aliases & Classifications for Unexplained Intellectual Disability

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Aliases & Descriptions for Unexplained Intellectual Disability:

Name: Unexplained Intellectual Disability 53

Classifications:



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Summaries for Unexplained Intellectual Disability

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MalaCards based summary: Unexplained Intellectual Disability is related to intellectual disability. An important gene associated with Unexplained Intellectual Disability is DDX3X (DEAD-Box Helicase 3, X-Linked). Affiliated tissues include thyroid.

Related Diseases for Unexplained Intellectual Disability

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Diseases related to Unexplained Intellectual Disability via text searches within MalaCards or GeneCards Suite gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1intellectual disability10.1

Symptoms for Unexplained Intellectual Disability

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Drugs & Therapeutics for Unexplained Intellectual Disability

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Drugs for Unexplained Intellectual Disability (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
CopperapprovedPhase 317215158-11-9, 7440-50-827099
Synonyms:
 
Copper
Cu
2MicronutrientsPhase 35802
3Trace ElementsPhase 35802
4histidineNutraceuticalPhase 342

Interventional clinical trials:

idNameStatusNCT IDPhase
1Molecular Bases of Response to Copper Treatment in Menkes Disease, Related Phenotypes, and Unexplained Copper DeficiencyRecruitingNCT00811785Phase 3
2Identification of Early Predictors of Fetomaternal HemorrhageCompletedNCT01232387
3Clinical and Genetic Analysis in Congenital Hypothyroidism Due to Thyroid Dysgenesis.Active, not recruitingNCT01916018

Search NIH Clinical Center for Unexplained Intellectual Disability

Genetic Tests for Unexplained Intellectual Disability

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Anatomical Context for Unexplained Intellectual Disability

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MalaCards organs/tissues related to Unexplained Intellectual Disability:

35
Thyroid

Animal Models for Unexplained Intellectual Disability or affiliated genes

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Publications for Unexplained Intellectual Disability

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Articles related to Unexplained Intellectual Disability:

idTitleAuthorsYear
1
Mutations in DDX3X Are a Common Cause of Unexplained Intellectual Disability with Gender-Specific Effects on Wnt Signaling. (26235985)
2015
2
Challenges and opportunities in the investigation of unexplained intellectual disability using family-based whole-exome sequencing. (25081361)
2014
3
High prevalence of array comparative genomic hybridization abnormalities in adults with unexplained intellectual disability. (20009761)
2010

Variations for Unexplained Intellectual Disability

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Expression for genes affiliated with Unexplained Intellectual Disability

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Search GEO for disease gene expression data for Unexplained Intellectual Disability.

Pathways for genes affiliated with Unexplained Intellectual Disability

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GO Terms for genes affiliated with Unexplained Intellectual Disability

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Sources for Unexplained Intellectual Disability

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet