Unilateral Absence of a Pulmonary Artery malady

NIH Rare Diseases:⁴⁸ Unilateral absence of the pulmonary artery (uapa) is a heart defect that is present from birth. the pulmonary artery takes blood from the heart to the lungs. in the absence of a pulmonary artery, other blood vessels compensate by supplying blood to the lungs. pressure can build inside these vessels and lead to heart and lung complications. uapa can be left sided or right sided. it most often occurs alone, but can occur with other heart anomalies and birth defects. signs and symptoms include repeat lung infections, lower exercise tolerance, shortness of breath, chest pain, and fluid in the lungs. risk for these symptoms increase with age. complications of uapa include, hemoptysis (coughing up blood), respiratory hemorrhage, and high blood pressure in the arteries to the lung (pulmonary hypertension). serious complications may be triggered by stress on the body, such as pregnancy and altitude sickness. last updated: 2/26/2014

MalaCards based summary: Unilateral Absence of a Pulmonary Artery, also known as isolated unilateral absence of a pulmonary artery, is related to urogenital adysplasia and immune-mediated encephalomyelitis. An important gene associated with Unilateral Absence of a Pulmonary Artery is THBD (Thrombomodulin), and among its related pathways are Formation of Fibrin Clot (Clotting Cascade) and Complement and coagulation cascades. Affiliated tissues include lung, heart and testes.

Search GEO for disease gene expression data for Unilateral Absence of a Pulmonary Artery.