MCID: UNL007
MIFTS: 30

Unilateral Renal Agenesis malady

Nephrological diseases, Fetal diseases categories

Summaries for Unilateral Renal Agenesis

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32MalaCards
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MalaCards: Unilateral Renal Agenesis is related to renal agenesis and nephrotic syndrome. An important gene associated with Unilateral Renal Agenesis is TGM1 (transglutaminase 1). The compounds cholesterol-sulfate and sorafenib have been mentioned in the context of this disorder. Related mouse phenotypes are limbs/digits/tail and integument.

Aliases & Classifications for Unilateral Renal Agenesis

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Sources:
48Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Fetal diseases
Anatomical: Nephrological diseases


Aliases & Descriptions:

unilateral renal agenesis 48


External Ids:

ICD10 via Orphanet26 Q60.0
SNOMED-CT via Orphanet57 55726006
UMLS via Orphanet61 C0266294
ICD1025 Q60.0, Q60.1

Related Diseases for Unilateral Renal Agenesis

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17GeneCards, 18GeneDecks
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Diseases related to Unilateral Renal Agenesis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 56)
idRelated DiseaseScoreTop Affiliating Genes
1renal agenesis31.6FRAS1, FREM2, RET
2nephrotic syndrome30.1NAGLU
3x-linked ichthyosis30.1STS
4kallmann syndrome30.1STS
5vesicoureteral reflux30.1NAGLU
6hypoparathyroidism30.1NAGLU, RET
7urethritis10.3
8cervicitis10.3
9hypertension10.3
10prostatitis10.3
11proteinuria10.3
12renal hypertension10.3
13vaginitis10.3
14focal segmental glomerulosclerosis10.2
15prostatic cyst10.2
16focal glomerulosclerosis10.2
17renal cell carcinoma10.2
18membranous glomerulonephritis10.1
19renal wilms' tumor10.1
20anuria10.1
21sotos syndrome10.1
22cryptorchidism10.1
23achondroplasia10.1
24aniridia10.1
25werner syndrome10.1
26familial medullary thyroid carcinoma10.1
27polydactyly10.1
28nevoid basal cell carcinoma syndrome10.1
29hypospadias10.1
30phenylketonuria10.1
31ureterocele10.1
32klippel-feil syndrome10.1
33hypogonadotropism10.1
34thyroid medullary carcinoma10.1
35autosomal recessive disease10.1
36basal cell carcinoma10.1
37glomerulonephritis10.1
38hypogonadism10.1
39kidney disease10.1
40squamous cell carcinoma10.1
41thyroiditis10.1
42urethral obstruction10.1
43urinary tract obstruction10.1
44congenital absence of the vas deferens10.1
45kabuki syndrome10.1
46aniridia renal agenesis psychomotor retardation10.1
47ellis yale winter syndrome10.1
48santos mateus leal syndrome10.1
49murcs association10.1
50classic mayer-rokitansky-küster-hauser syndrome10.1

Graphical network of the top 20 diseases related to Unilateral Renal Agenesis:



Diseases related to unilateral renal agenesis

Clinical Features for Unilateral Renal Agenesis

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Drugs & Therapeutics for Unilateral Renal Agenesis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Unilateral Renal Agenesis

Drug clinical trials:

Search ClinicalTrials for Unilateral Renal Agenesis

Search NIH Clinical Center for Unilateral Renal Agenesis

Search CenterWatch for Unilateral Renal Agenesis

Genetic Tests for Unilateral Renal Agenesis

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Anatomical Context for Unilateral Renal Agenesis

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Animal Models for Unilateral Renal Agenesis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Unilateral Renal Agenesis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053718.5RET, FRAS1, FREM2
2MP:00107718.2NAGLU, FREM2, FRAS1, TGM1
3MP:00053678.1RET, NAGLU, FREM2, FRAS1
4MP:00053857.8FREM2, NAGLU, RET, FRAS1
5MP:00107687.5RET, NAGLU, FREM2, FRAS1, TGM1

Publications for Unilateral Renal Agenesis

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Genetic Variations for Unilateral Renal Agenesis

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Expression for genes affiliated with Unilateral Renal Agenesis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Unilateral Renal Agenesis

Search GEO for disease gene expression data for Unilateral Renal Agenesis.

Pathways for genes affiliated with Unilateral Renal Agenesis

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Compounds for genes affiliated with Unilateral Renal Agenesis

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Sources:
44Novoseek, 11DrugBank, 49PharmGKB, 24HMDB
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Compounds related to Unilateral Renal Agenesis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1cholesterol-sulfate44 1110.7STS, TGM1
2sorafenib44 49 1111.5RET, STS
3heparan sulfate44 2410.5RET, NAGLU
4lead449.4NAGLU, STS
5vitamin a44 11 2411.2TGM1, NAGLU, RET
6sulfate44 2410.2NAGLU, STS
7steroid449.1NAGLU, TGM1, STS
8lipid448.7RET, TGM1, NAGLU, STS
9calcium44 49 11 2410.3STS, RET, NAGLU, FREM2, FRAS1, TGM1

GO Terms for genes affiliated with Unilateral Renal Agenesis

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16Gene Ontology
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Cellular components related to Unilateral Renal Agenesis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1basement membraneGO:0056049.0FRAS1, FREM2

Biological processes related to Unilateral Renal Agenesis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1homophilic cell adhesionGO:0071569.3FREM2, RET
2morphogenesis of an epitheliumGO:0020098.9FRAS1, FREM2
3cell communicationGO:0071548.7FRAS1, FREM2

Products for genes affiliated with Unilateral Renal Agenesis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Unilateral Renal Agenesis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet