MCID: UNL002
MIFTS: 32

Unilateral Retinoblastoma

Categories: Neuronal diseases, Cancer diseases

Aliases & Classifications for Unilateral Retinoblastoma

MalaCards integrated aliases for Unilateral Retinoblastoma:

Name: Unilateral Retinoblastoma 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:4651
NCIt 46 C8714
UMLS 69 C0854915

Summaries for Unilateral Retinoblastoma

Disease Ontology : 12 A retinoblastoma that effects only one eye.

MalaCards based summary : Unilateral Retinoblastoma is related to bilateral retinoblastoma and retinoblastoma. An important gene associated with Unilateral Retinoblastoma is RB1 (RB Transcriptional Corepressor 1), and among its related pathways/superpathways are Mitotic G1-G1/S phases and Adipogenesis. The drugs Carboplatin and Etoposide have been mentioned in the context of this disorder. Affiliated tissues include eye, pineal and testes.

Related Diseases for Unilateral Retinoblastoma

Diseases related to Unilateral Retinoblastoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 23)
# Related Disease Score Top Affiliating Genes
1 bilateral retinoblastoma 29.5 RB1 RBL1
2 retinoblastoma 10.6
3 aging 10.0
4 retinal cancer 10.0 RB1 RBL1
5 sensory system cancer 9.9 RB1 RBL1
6 intraocular retinoblastoma 9.9 GREM2 RBL1
7 ocular cancer 9.9 RB1 RBL1
8 pineoblastoma 9.8
9 teratoma 9.8
10 retinitis 9.8
11 nervous system cancer 9.7 RB1 RBL1
12 neuroblastoma 9.6
13 peters-plus syndrome 9.6
14 meningioma, familial 9.6
15 leukemia 9.6
16 nasopharyngitis 9.6
17 sarcoma 9.6
18 leydig cell tumor 9.6
19 rhabdomyosarcoma 9.6
20 cerebritis 9.6
21 mature teratoma 9.6
22 ovarian germ cell teratoma 9.6
23 acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) 9.6

Graphical network of the top 20 diseases related to Unilateral Retinoblastoma:



Diseases related to Unilateral Retinoblastoma

Symptoms & Phenotypes for Unilateral Retinoblastoma

Drugs & Therapeutics for Unilateral Retinoblastoma

Drugs for Unilateral Retinoblastoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 33)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Carboplatin Approved Phase 3,Phase 2 41575-94-4 10339178 38904 498142
2
Etoposide Approved Phase 3,Phase 2 33419-42-0 36462
3
Vincristine Approved, Investigational Phase 3,Phase 2 2068-78-2, 57-22-7 5978
4
Cyclophosphamide Approved, Investigational Phase 3,Phase 2 50-18-0, 6055-19-2 2907
5
Doxorubicin Approved, Investigational Phase 3,Phase 2 23214-92-8 31703
6
Mesna Approved, Investigational Phase 3,Phase 2 3375-50-6 598
7
Topotecan Approved, Investigational Phase 3,Phase 2 119413-54-6, 123948-87-8 60700
8
Doxil Approved June 1999 Phase 3,Phase 2 31703
9 Antimitotic Agents Phase 3,Phase 2
10 Antineoplastic Agents, Phytogenic Phase 3,Phase 2
11 Etoposide phosphate Phase 3,Phase 2
12 Topoisomerase Inhibitors Phase 3,Phase 2
13 Immunosuppressive Agents Phase 3,Phase 2
14 Alkylating Agents Phase 3,Phase 2
15 Anti-Bacterial Agents Phase 3,Phase 2
16 Antibiotics, Antitubercular Phase 3,Phase 2
17 Antirheumatic Agents Phase 3,Phase 2
18 topoisomerase I inhibitors Phase 3,Phase 2
19 Anesthetics Phase 3,Phase 2
20 Thiotepa Approved, Investigational Phase 2 52-24-4 5453
21
Lenograstim Approved, Investigational Phase 2 135968-09-1
22
Menthol Approved Phase 2 2216-51-5 16666
23 Adjuvants, Immunologic Phase 2
24
Cytarabine Approved, Investigational 147-94-4 6253
25
Mechlorethamine Approved, Investigational 51-75-2 4033
26
Melphalan Approved 148-82-3 460612 4053
27 Anti-Infective Agents
28 Antimetabolites
29 Antimetabolites, Antineoplastic
30 Antiviral Agents
31 Nitrogen Mustard Compounds
32 alanine Nutraceutical
33 phenylalanine Nutraceutical

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Vincristine, Carboplatin, and Etoposide or Observation Only in Treating Patients Who Have Undergone Surgery for Newly Diagnosed Retinoblastoma Completed NCT00335738 Phase 3 liposomal vincristine sulfate;carboplatin;etoposide
2 Study of Treatment for Patients With Cancer of the Eye -Retinoblastoma Active, not recruiting NCT00186888 Phase 3 Vincristine, Carboplatin;Vincristine + Topotecan;Vincristine + Carboplatin + Etoposide;Vincristine + Cyclophosphamide + Doxorubicin;Vincristine+Carboplatin+Etoposide
3 Adjuvant Treatment in Extensive Unilateral Retinoblastoma Primary Enucleated (RB SFCE 2009) Recruiting NCT02870907 Phase 2 Etoposide;Vincristine;Carboplatin;Vincristine;Cyclophosphamide;Carboplatin;Etoposide;Carboplatin;Thiotepa;Vincristine;Cyclophosphamide;Carboplatin;Etoposide;Thiotepa
4 Protocol for the Study and Treatment of Participants With Intraocular Retinoblastoma Recruiting NCT01783535 Phase 2 vincristine;topotecan;filgrastim;PEG-filgrastim;carboplatin;etoposide;cyclophosphamide;MESNA;doxorubicin
5 Proton Beam Radiation Therapy for Intraocular and Periocular Retinoblastoma Terminated NCT00432445 Phase 2
6 Chemotherapy With or Without Radiation Therapy or Observation in Treating Young Patients With Advanced Retinoblastoma Who Have Undergone Surgery to Remove the Eye Unknown status NCT00360750 carboplatin;cytarabine;etoposide;vincristine sulfate
7 Intra-arterial Melphalan in Treating Younger Patients With Unilateral Retinoblastoma Active, not recruiting NCT02097134 Melphalan
8 Alternating Systemic Chemotherapy and Intra-Arterial Melphalan Chemotherapy in Children With Intra-Ocular Retinoblastoma Active, not recruiting NCT02116959 Melphalan;Carboplatin;Etoposide;Vincristine

Search NIH Clinical Center for Unilateral Retinoblastoma

Genetic Tests for Unilateral Retinoblastoma

Anatomical Context for Unilateral Retinoblastoma

MalaCards organs/tissues related to Unilateral Retinoblastoma:

38
Eye, Pineal, Testes

Publications for Unilateral Retinoblastoma

Articles related to Unilateral Retinoblastoma:

(show top 50) (show all 73)
# Title Authors Year
1
Mature Ovarian Teratoma After Treatment for Unilateral Retinoblastoma With Nonmutated RB1. ( 28719514 )
2017
2
Lack of correlation between age at diagnosis and RB1 mutations for unilateral retinoblastoma: the importance of genetic testing. ( 29286867 )
2017
3
MONTE CARLO SIMULATION OF OUT-OF-FIELD ORGAN DOSES AND CANCER RISK IN TANZANIA FOR RADIATION THERAPY OF UNILATERAL RETINOBLASTOMA USING A 60Co UNIT. ( 29216393 )
2017
4
Giant retinal tear after intra-arterial chemotherapy for advanced unilateral retinoblastoma. ( 28815057 )
2017
5
Second Primary Rhabdomyosarcoma in Nonhereditary Unilateral Retinoblastoma Not Treated with Radiotherapy. ( 28682022 )
2017
6
Unilateral Retinoblastoma Managed With Intravenous Chemotherapy Versus Intra-Arterial Chemotherapy. Outcomes Based on the International Classification of Retinoblastoma. ( 26765038 )
2016
7
Advanced unilateral retinoblastoma: a case of sparing enucleation treatment failure. ( 27085272 )
2016
8
Uncommon RB1 somatic mutations in a unilateral retinoblastoma patient. ( 26117602 )
2015
9
Advanced Unilateral Retinoblastoma: The Impact of Ophthalmic Artery Chemosurgery on Enucleation Rate and Patient Survival at MSKCC. ( 26709699 )
2015
10
Mutation spectrum of RB1 gene in unilateral retinoblastoma cases from Tunisia and correlations with clinical features. ( 25602518 )
2015
11
Maternal diet during pregnancy and unilateral retinoblastoma. ( 25542139 )
2015
12
From a Suspicious Cystic Pineal Gland to Pineoblastoma in a Patient with Familial Unilateral Retinoblastoma. ( 24940935 )
2014
13
Pathologic risk-based adjuvant chemotherapy for unilateral retinoblastoma following enucleation. ( 24577551 )
2014
14
Clinical treatment and prognostic observation for different pathological infiltrations in 537 patients with unilateral retinoblastoma. ( 25316233 )
2014
15
Multiple atypical recurrent meningiomas 13 years after radiotherapy for unilateral retinoblastoma: case report and review of the literature. ( 23487298 )
2013
16
Results of a multicenter prospective study on the postoperative treatment of unilateral retinoblastoma after primary enucleation. ( 23460706 )
2013
17
Sporadic unilateral retinoblastoma or first sign of bilateral disease? ( 23355526 )
2013
18
Enucleated eyes after failed intra-arterial infusion of chemotherapy for unilateral retinoblastoma: histopathologic evaluation of vitreous seeding. ( 22174572 )
2011
19
A 20.5-Mb germline deletion of 13q13.1-->q14.3 and somatic mutations of the RB1 gene in an 8-year-old girl with unilateral retinoblastoma, developmental delay and mental retardation. ( 22303805 )
2011
20
Ewing's sarcoma as second malignancy following a short latency in unilateral retinoblastoma. ( 21826516 )
2011
21
Results of a prospective study for the treatment of unilateral retinoblastoma. ( 20486172 )
2010
22
Unilateral retinoblastoma in an eye with Peters anomaly. ( 20451864 )
2010
23
Molecular karyotype of sporadic unilateral retinoblastoma tumors. ( 19491728 )
2009
24
Management and outcome of unilateral retinoblastoma. ( 20006813 )
2009
25
Some clinical findings at presentation can predict high-risk pathology features in unilateral retinoblastoma. ( 19415010 )
2009
26
Ki-67 cell proliferation in familial and in esporadic unilateral retinoblastoma: case report. ( 17589712 )
2007
27
Comparison of orbital volumes in enucleated patients with unilateral retinoblastoma: hydroxyapatite implants versus silicone implants. ( 17881992 )
2007
28
Unilateral retinoblastoma, lack of familial history and older age does not exclude germline RB1 gene mutation. ( 16343894 )
2006
29
Age at diagnosis of isolated unilateral retinoblastoma does not distinguish patients with and without a constitutional RB1 gene mutation but is influenced by a parent-of-origin effect. ( 15763650 )
2005
30
Neoadjuvant chemotherapy for extensive unilateral retinoblastoma. ( 12598448 )
2003
31
Brief report: conservative treatment in unilateral retinoblastoma: a preliminary report. ( 11984807 )
2002
32
Chemoreduction for unilateral retinoblastoma. ( 12470138 )
2002
33
Electroretinographic changes in the inner retinal layers of the retained eyes of patients with sporadic unilateral retinoblastoma. ( 12187428 )
2002
34
Leydig cell tumor and mature teratoma: unusual non-ocular tumors associated with sexual pseudo-precocity six years after unilateral retinoblastoma. ( 11920800 )
2002
35
Evaluation of chemoprophylaxis in patients with unilateral retinoblastoma with high-risk features on histopathologic examination. ( 11146725 )
2001
36
Mutation of the RB1 gene caused unilateral retinoblastoma in early Age. ( 10812163 )
2000
37
Metachronous tumor development in unilateral retinoblastoma. ( 10887927 )
2000
38
Isolated granulocytic myelodysplasia in a child with unilateral retinoblastoma. ( 11020113 )
2000
39
Is screening for primitive neuroectodermal tumors in patients with unilateral retinoblastoma necessary? ( 10675872 )
2000
40
A constitutional homozygous mutation in the RB1 gene in a patient with unilateral retinoblastoma. ( 10991691 )
2000
41
Frequency and nature of germline Rb-1 gene mutations in a series of patients with sporadic unilateral retinoblastoma. ( 10673998 )
1999
42
No association between the presence of a constitutional RB1 gene mutation and age in 68 patients with isolated unilateral retinoblastoma. ( 10533490 )
1999
43
RB1 gene mutations in peripheral blood DNA of patients with isolated unilateral retinoblastoma. ( 9973307 )
1999
44
Age at diagnosis to discriminate those patients for whom constitutional DNA sequencing is appropriate in sporadic unilateral retinoblastoma. ( 10023315 )
1998
45
Unilateral retinoblastoma with acquired monosomy 7 and secondary acute myelomonocytic leukemia. ( 9689935 )
1998
46
Unilateral retinoblastoma in adults. ( 9261300 )
1997
47
Constitutional RB1-gene mutations in patients with isolated unilateral retinoblastoma. ( 9311732 )
1997
48
Unilateral retinoblastoma in an adult. ( 9373097 )
1997
49
Cerebral primitive neuro-ectodermal tumour following treatment of a unilateral retinoblastoma. ( 9309290 )
1997
50
Unilateral retinoblastoma in an adult: report of a case and review of the literature. ( 9022103 )
1997

Variations for Unilateral Retinoblastoma

Expression for Unilateral Retinoblastoma

Search GEO for disease gene expression data for Unilateral Retinoblastoma.

Pathways for Unilateral Retinoblastoma

Pathways related to Unilateral Retinoblastoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.85 DHFR RB1 RBL1
2 11.52 RB1 RBL1
3 11.31 DHFR RB1
4
Show member pathways
11.25 RB1 RBL1
5
Show member pathways
10.97 RB1 RBL1
6 10.66 DHFR RB1 RBL1
7 10.16 RB1 RBL1

GO Terms for Unilateral Retinoblastoma

Biological processes related to Unilateral Retinoblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of cell cycle GO:0051726 9.16 RB1 RBL1
2 regulation of transcription involved in G1/S transition of mitotic cell cycle GO:0000083 8.96 DHFR RB1
3 regulation of lipid kinase activity GO:0043550 8.62 RB1 RBL1

Molecular functions related to Unilateral Retinoblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA binding GO:0003729 8.62 DHFR XPO5

Sources for Unilateral Retinoblastoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....