MCID: UNL002
MIFTS: 32

Unilateral Retinoblastoma

Categories: Cancer diseases, Neuronal diseases, Eye diseases

Aliases & Classifications for Unilateral Retinoblastoma

MalaCards integrated aliases for Unilateral Retinoblastoma:

Name: Unilateral Retinoblastoma 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:4651
NCIt 47 C8714
UMLS 69 C0854915

Summaries for Unilateral Retinoblastoma

Disease Ontology : 12 A retinoblastoma that effects only one eye.

MalaCards based summary : Unilateral Retinoblastoma is related to retinoblastoma and extraocular retinoblastoma. An important gene associated with Unilateral Retinoblastoma is RB1 (RB Transcriptional Corepressor 1), and among its related pathways/superpathways are Mitotic G1-G1/S phases and Adipogenesis. The drugs Carboplatin and Etoposide have been mentioned in the context of this disorder. Affiliated tissues include eye and pineal, and related phenotypes are immune system and integument

Related Diseases for Unilateral Retinoblastoma

Diseases related to Unilateral Retinoblastoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 20)
id Related Disease Score Top Affiliating Genes
1 retinoblastoma 10.5
2 extraocular retinoblastoma 10.1 RB1 RBL1
3 pharynx cancer 10.1 RB1 RBL1
4 post-surgical hypoinsulinemia 10.0 RB1 RBL1
5 small cell sarcoma 9.9 RB1 RBL1
6 pineoblastoma 9.7
7 teratoma 9.7
8 retinitis 9.7
9 extracutaneous mastocytoma 9.7 GREM2 RBL1
10 neuroblastoma 9.6
11 leukemia 9.6
12 nasopharyngitis 9.6
13 sarcoma 9.6
14 leydig cell tumor 9.6
15 rhabdomyosarcoma 9.6
16 cerebritis 9.6
17 bilateral retinoblastoma 9.6
18 mature teratoma 9.6
19 small cell cancer of the lung, somatic 9.5 DHFR RB1
20 benign mastocytoma 7.7 ABCC4 DHFR GREM2 RB1 RBL1 XPO5

Graphical network of the top 20 diseases related to Unilateral Retinoblastoma:



Diseases related to Unilateral Retinoblastoma

Symptoms & Phenotypes for Unilateral Retinoblastoma

MGI Mouse Phenotypes related to Unilateral Retinoblastoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.26 ABCC4 GREM2 RB1 RBL1
2 integument MP:0010771 8.8 ABCC4 RB1 RBL1

Drugs & Therapeutics for Unilateral Retinoblastoma

Drugs for Unilateral Retinoblastoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 34)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Carboplatin Approved Phase 3,Phase 2 41575-94-4 10339178 498142 38904
2
Etoposide Approved Phase 3,Phase 2 33419-42-0 36462
3
Vincristine Approved, Investigational Phase 3,Phase 2 2068-78-2, 57-22-7 5978
4
Cyclophosphamide Approved, Investigational Phase 3,Phase 2 50-18-0, 6055-19-2 2907
5
Doxorubicin Approved, Investigational Phase 3,Phase 2 23214-92-8 31703
6
Mesna Approved Phase 3,Phase 2 3375-50-6 598
7
Topotecan Approved, Investigational Phase 3,Phase 2 119413-54-6, 123948-87-8 60700
8
Doxil Approved June 1999 Phase 3,Phase 2 31703
9 Antimitotic Agents Phase 3,Phase 2
10 Antineoplastic Agents, Phytogenic Phase 3,Phase 2
11 Etoposide phosphate Phase 3,Phase 2
12 Topoisomerase Inhibitors Phase 3,Phase 2
13 Immunosuppressive Agents Phase 3,Phase 2
14 Alkylating Agents Phase 3,Phase 2
15 Anti-Bacterial Agents Phase 3,Phase 2
16 Antibiotics, Antitubercular Phase 3,Phase 2
17 Antirheumatic Agents Phase 3,Phase 2
18 topoisomerase I inhibitors Phase 3,Phase 2
19 Anesthetics Phase 3,Phase 2
20 Thiotepa Approved Phase 2 52-24-4 5453
21
Lenograstim Approved Phase 2 135968-09-1
22
Menthol Approved Phase 2 2216-51-5 16666
23
Melphalan Approved Phase 2 148-82-3 4053 460612
24 Adjuvants, Immunologic Phase 2
25
Cytarabine Approved, Investigational 147-94-4 6253
26
Mechlorethamine Approved 51-75-2 4033
27
Ethanol Approved 64-17-5 702
28 Anti-Infective Agents
29 Antimetabolites
30 Antimetabolites, Antineoplastic
31 Antiviral Agents
32 Nitrogen Mustard Compounds
33 alanine Nutraceutical
34 phenylalanine Nutraceutical

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Vincristine, Carboplatin, and Etoposide or Observation Only in Treating Patients Who Have Undergone Surgery for Newly Diagnosed Retinoblastoma Completed NCT00335738 Phase 3 liposomal vincristine sulfate;carboplatin;etoposide
2 Study of Treatment for Patients With Cancer of the Eye -Retinoblastoma Active, not recruiting NCT00186888 Phase 3 Vincristine, Carboplatin;Vincristine + Topotecan;Vincristine + Carboplatin + Etoposide;Vincristine + Cyclophosphamide + Doxorubicin;Vincristine+Carboplatin+Etoposide
3 Adjuvant Treatment in Extensive Unilateral Retinoblastoma Primary Enucleated (RB SFCE 2009) Recruiting NCT02870907 Phase 2 Etoposide;Vincristine;Carboplatin;Vincristine;Cyclophosphamide;Carboplatin;Etoposide;Carboplatin;Thiotepa;Vincristine;Cyclophosphamide;Carboplatin;Etoposide;Thiotepa
4 Protocol for the Study and Treatment of Participants With Intraocular Retinoblastoma Recruiting NCT01783535 Phase 2 vincristine;topotecan;filgrastim;PEG-filgrastim;carboplatin;etoposide;cyclophosphamide;MESNA;doxorubicin
5 Conservative Treatments of Retinoblastoma Recruiting NCT02866136 Phase 2 VP16, carboplatin;Melphalan;VP16, carboplatin, vincristin;Carboplatin + laser day 1 (chemothermotherapy);intravitreal Melphalan (local treatment)
6 Proton Beam Radiation Therapy for Intraocular and Periocular Retinoblastoma Terminated NCT00432445 Phase 2
7 Intra-arterial Chemotherapy for the Treatment of Intraocular Retinoblastoma Terminated NCT01293539 Phase 2 Melphalan hydrochloride
8 Chemotherapy With or Without Radiation Therapy or Observation in Treating Young Patients With Advanced Retinoblastoma Who Have Undergone Surgery to Remove the Eye Unknown status NCT00360750 carboplatin;cytarabine;etoposide;vincristine sulfate
9 Intra-arterial Melphalan in Treating Younger Patients With Unilateral Retinoblastoma Active, not recruiting NCT02097134 Melphalan
10 Genetic Mutations and Environmental Exposure in Young Patients With Retinoblastoma and in Their Parents and Young Healthy Unrelated Volunteers Active, not recruiting NCT00690469

Search NIH Clinical Center for Unilateral Retinoblastoma

Genetic Tests for Unilateral Retinoblastoma

Anatomical Context for Unilateral Retinoblastoma

MalaCards organs/tissues related to Unilateral Retinoblastoma:

39
Eye, Pineal

Publications for Unilateral Retinoblastoma

Articles related to Unilateral Retinoblastoma:

(show top 50) (show all 71)
id Title Authors Year
1
Mature Ovarian Teratoma After Treatment for Unilateral Retinoblastoma With Nonmutated RB1. ( 28719514 )
2017
2
Giant retinal tear after intra-arterial chemotherapy for advanced unilateral retinoblastoma. ( 28815057 )
2017
3
Second Primary Rhabdomyosarcoma in Nonhereditary Unilateral Retinoblastoma Not Treated with Radiotherapy. ( 28682022 )
2017
4
Unilateral Retinoblastoma Managed With Intravenous Chemotherapy Versus Intra-Arterial Chemotherapy. Outcomes Based on the International Classification of Retinoblastoma. ( 26765038 )
2016
5
Advanced unilateral retinoblastoma: a case of sparing enucleation treatment failure. ( 27085272 )
2016
6
Uncommon RB1 somatic mutations in a unilateral retinoblastoma patient. ( 26117602 )
2015
7
Mutation spectrum of RB1 gene in unilateral retinoblastoma cases from Tunisia and correlations with clinical features. ( 25602518 )
2015
8
Maternal diet during pregnancy and unilateral retinoblastoma. ( 25542139 )
2015
9
Advanced Unilateral Retinoblastoma: The Impact of Ophthalmic Artery Chemosurgery on Enucleation Rate and Patient Survival at MSKCC. ( 26709699 )
2015
10
From a Suspicious Cystic Pineal Gland to Pineoblastoma in a Patient with Familial Unilateral Retinoblastoma. ( 24940935 )
2014
11
Clinical treatment and prognostic observation for different pathological infiltrations in 537 patients with unilateral retinoblastoma. ( 25316233 )
2014
12
Pathologic risk-based adjuvant chemotherapy for unilateral retinoblastoma following enucleation. ( 24577551 )
2014
13
Sporadic unilateral retinoblastoma or first sign of bilateral disease? ( 23355526 )
2013
14
Multiple atypical recurrent meningiomas 13 years after radiotherapy for unilateral retinoblastoma: case report and review of the literature. ( 23487298 )
2013
15
Results of a multicenter prospective study on the postoperative treatment of unilateral retinoblastoma after primary enucleation. ( 23460706 )
2013
16
Enucleated eyes after failed intra-arterial infusion of chemotherapy for unilateral retinoblastoma: histopathologic evaluation of vitreous seeding. ( 22174572 )
2011
17
A 20.5-Mb germline deletion of 13q13.1-->q14.3 and somatic mutations of the RB1 gene in an 8-year-old girl with unilateral retinoblastoma, developmental delay and mental retardation. ( 22303805 )
2011
18
Ewing's sarcoma as second malignancy following a short latency in unilateral retinoblastoma. ( 21826516 )
2011
19
Unilateral retinoblastoma in an eye with Peters anomaly. ( 20451864 )
2010
20
Results of a prospective study for the treatment of unilateral retinoblastoma. ( 20486172 )
2010
21
Management and outcome of unilateral retinoblastoma. ( 20006813 )
2009
22
Molecular karyotype of sporadic unilateral retinoblastoma tumors. ( 19491728 )
2009
23
Some clinical findings at presentation can predict high-risk pathology features in unilateral retinoblastoma. ( 19415010 )
2009
24
Ki-67 cell proliferation in familial and in esporadic unilateral retinoblastoma: case report. ( 17589712 )
2007
25
Comparison of orbital volumes in enucleated patients with unilateral retinoblastoma: hydroxyapatite implants versus silicone implants. ( 17881992 )
2007
26
Unilateral retinoblastoma, lack of familial history and older age does not exclude germline RB1 gene mutation. ( 16343894 )
2006
27
Age at diagnosis of isolated unilateral retinoblastoma does not distinguish patients with and without a constitutional RB1 gene mutation but is influenced by a parent-of-origin effect. ( 15763650 )
2005
28
Neoadjuvant chemotherapy for extensive unilateral retinoblastoma. ( 12598448 )
2003
29
Brief report: conservative treatment in unilateral retinoblastoma: a preliminary report. ( 11984807 )
2002
30
Chemoreduction for unilateral retinoblastoma. ( 12470138 )
2002
31
Electroretinographic changes in the inner retinal layers of the retained eyes of patients with sporadic unilateral retinoblastoma. ( 12187428 )
2002
32
Leydig cell tumor and mature teratoma: unusual non-ocular tumors associated with sexual pseudo-precocity six years after unilateral retinoblastoma. ( 11920800 )
2002
33
Evaluation of chemoprophylaxis in patients with unilateral retinoblastoma with high-risk features on histopathologic examination. ( 11146725 )
2001
34
Metachronous tumor development in unilateral retinoblastoma. ( 10887927 )
2000
35
Is screening for primitive neuroectodermal tumors in patients with unilateral retinoblastoma necessary? ( 10675872 )
2000
36
Isolated granulocytic myelodysplasia in a child with unilateral retinoblastoma. ( 11020113 )
2000
37
Mutation of the RB1 gene caused unilateral retinoblastoma in early Age. ( 10812163 )
2000
38
A constitutional homozygous mutation in the RB1 gene in a patient with unilateral retinoblastoma. ( 10991691 )
2000
39
No association between the presence of a constitutional RB1 gene mutation and age in 68 patients with isolated unilateral retinoblastoma. ( 10533490 )
1999
40
RB1 gene mutations in peripheral blood DNA of patients with isolated unilateral retinoblastoma. ( 9973307 )
1999
41
Frequency and nature of germline Rb-1 gene mutations in a series of patients with sporadic unilateral retinoblastoma. ( 10673998 )
1999
42
Unilateral retinoblastoma with acquired monosomy 7 and secondary acute myelomonocytic leukemia. ( 9689935 )
1998
43
Age at diagnosis to discriminate those patients for whom constitutional DNA sequencing is appropriate in sporadic unilateral retinoblastoma. ( 10023315 )
1998
44
Unilateral retinoblastoma in an adult: report of a case and review of the literature. ( 9022103 )
1997
45
Unilateral retinoblastoma in adults. ( 9261300 )
1997
46
Cerebral primitive neuro-ectodermal tumour following treatment of a unilateral retinoblastoma. ( 9309290 )
1997
47
Unilateral retinoblastoma in an adult. ( 9373097 )
1997
48
Constitutional RB1-gene mutations in patients with isolated unilateral retinoblastoma. ( 9311732 )
1997
49
Deletion of Rb1 gene in late osteosarcoma from survivor of unilateral retinoblastoma--a case report. ( 8703379 )
1996
50
Nasopharyngeal osteosarcoma as second malignant neoplasm in a post-treated unilateral retinoblastoma: report of a case and review of literature. ( 8839078 )
1996

Variations for Unilateral Retinoblastoma

Expression for Unilateral Retinoblastoma

Search GEO for disease gene expression data for Unilateral Retinoblastoma.

Pathways for Unilateral Retinoblastoma

Pathways related to Unilateral Retinoblastoma according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
11.95 DHFR RB1 RBL1
2 11.55 RB1 RBL1
3 11.35 DHFR RB1
4
Show member pathways
11.3 RB1 RBL1
5
Show member pathways
11.04 RB1 RBL1
6 10.66 DHFR RB1 RBL1
7 10.65 ABCC4 DHFR
8 10.16 RB1 RBL1

GO Terms for Unilateral Retinoblastoma

Biological processes related to Unilateral Retinoblastoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 regulation of cell cycle GO:0051726 9.16 RB1 RBL1
2 regulation of transcription involved in G1/S transition of mitotic cell cycle GO:0000083 8.96 DHFR RB1
3 regulation of lipid kinase activity GO:0043550 8.62 RB1 RBL1

Molecular functions related to Unilateral Retinoblastoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 mRNA binding GO:0003729 8.62 DHFR XPO5

Sources for Unilateral Retinoblastoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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