MCID: UNL002
MIFTS: 32

Unilateral Retinoblastoma malady

Categories: Cancer diseases, Neuronal diseases, Eye diseases

Aliases & Classifications for Unilateral Retinoblastoma

Aliases & Descriptions for Unilateral Retinoblastoma:

Name: Unilateral Retinoblastoma 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:4651
NCIt 47 C8714
UMLS 69 C0854915

Summaries for Unilateral Retinoblastoma

Disease Ontology : 12 A retinoblastoma that effects only one eye.

MalaCards based summary : Unilateral Retinoblastoma is related to retinoblastoma and extracutaneous mastocytoma. An important gene associated with Unilateral Retinoblastoma is RB1 (RB Transcriptional Corepressor 1), and among its related pathways/superpathways are Mitotic G1-G1/S phases and Cyclins and Cell Cycle Regulation. The drugs Vincristine and Etoposide have been mentioned in the context of this disorder. Affiliated tissues include eye and pineal.

Related Diseases for Unilateral Retinoblastoma

Diseases related to Unilateral Retinoblastoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 20)
id Related Disease Score Top Affiliating Genes
1 retinoblastoma 10.5
2 extracutaneous mastocytoma 10.1 RB1 RBL1
3 extraocular retinoblastoma 10.0 RB1 RBL1
4 thoracic outlet syndrome 10.0 RB1 RBL1
5 integumentary system benign neoplasm 10.0 RB1 RBL1
6 astigmatism 9.9 NDP RB1
7 post-surgical hypoinsulinemia 9.9 RB1 RBL1
8 pineoblastoma 9.7
9 neuroblastoma 9.6
10 peters anomaly 9.6
11 leukemia 9.6
12 nasopharyngitis 9.6
13 sarcoma 9.6
14 leydig cell tumor 9.6
15 teratoma 9.6
16 cerebritis 9.6
17 retinitis 9.6
18 bilateral retinoblastoma 9.6
19 mature teratoma 9.6
20 indolent systemic mastocytosis 9.1 DHFR HDAC9 NDP RB1 RBL1 XPO5

Graphical network of the top 20 diseases related to Unilateral Retinoblastoma:



Diseases related to Unilateral Retinoblastoma

Symptoms & Phenotypes for Unilateral Retinoblastoma

Drugs & Therapeutics for Unilateral Retinoblastoma

Drugs for Unilateral Retinoblastoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 35)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Vincristine Approved, Investigational Phase 3,Phase 2 2068-78-2, 57-22-7 5978
2
Etoposide Approved Phase 3,Phase 2 33419-42-0 36462
3
Carboplatin Approved Phase 3,Phase 2 41575-94-4 10339178 498142 38904
4
Doxorubicin Approved, Investigational Phase 3,Phase 2 23214-92-8 31703
5
Topotecan Approved, Investigational Phase 3,Phase 2 119413-54-6, 123948-87-8 60700
6
Cyclophosphamide Approved, Investigational Phase 3,Phase 2 50-18-0, 6055-19-2 2907
7
Mesna Approved Phase 3,Phase 2 3375-50-6 598
8
Doxil Approved June 1999 Phase 3,Phase 2 31703
9 Topoisomerase Inhibitors Phase 3,Phase 2
10 Etoposide phosphate Phase 3,Phase 2
11 Immunosuppressive Agents Phase 3,Phase 2
12 Antimitotic Agents Phase 3,Phase 2
13 Antineoplastic Agents, Phytogenic Phase 3,Phase 2
14 Alkylating Agents Phase 3,Phase 2
15 topoisomerase I inhibitors Phase 3,Phase 2
16 Anti-Bacterial Agents Phase 3,Phase 2
17 Antibiotics, Antitubercular Phase 3,Phase 2
18 Antirheumatic Agents Phase 3,Phase 2
19 Antineoplastic Agents, Alkylating Phase 3,Phase 2
20 Anesthetics Phase 3,Phase 2
21
Melphalan Approved Phase 2 148-82-3 4053 460612
22
Thiotepa Approved Phase 2 52-24-4 5453
23
Lenograstim Approved Phase 2 135968-09-1
24
Menthol Approved Phase 2 2216-51-5 16666
25 Adjuvants, Immunologic Phase 2
26
Cytarabine Approved, Investigational 147-94-4 6253
27
Ethanol Approved 64-17-5 702
28
Mechlorethamine Approved 51-75-2 4033
29 Anti-Infective Agents
30 Antimetabolites
31 Antimetabolites, Antineoplastic
32 Antiviral Agents
33 Nitrogen Mustard Compounds
34 alanine Nutraceutical
35 phenylalanine Nutraceutical

Interventional clinical trials:


id Name Status NCT ID Phase
1 Vincristine, Carboplatin, and Etoposide or Observation Only in Treating Patients Who Have Undergone Surgery for Newly Diagnosed Retinoblastoma Completed NCT00335738 Phase 3
2 Study of Treatment for Patients With Cancer of the Eye -Retinoblastoma Active, not recruiting NCT00186888 Phase 3
3 Adjuvant Treatment in Extensive Unilateral Retinoblastoma Primary Enucleated (RB SFCE 2009) Recruiting NCT02870907 Phase 2
4 Protocol for the Study and Treatment of Participants With Intraocular Retinoblastoma Recruiting NCT01783535 Phase 2
5 Conservative Treatments of Retinoblastoma Recruiting NCT02866136 Phase 2
6 Proton Beam Radiation Therapy for Intraocular and Periocular Retinoblastoma Terminated NCT00432445 Phase 2
7 Chemotherapy With or Without Radiation Therapy or Observation in Treating Young Patients With Advanced Retinoblastoma Who Have Undergone Surgery to Remove the Eye Unknown status NCT00360750
8 Intra-arterial Melphalan in Treating Younger Patients With Unilateral Retinoblastoma Active, not recruiting NCT02097134
9 Genetic Mutations and Environmental Exposure in Young Patients With Retinoblastoma and in Their Parents and Young Healthy Unrelated Volunteers Active, not recruiting NCT00690469

Search NIH Clinical Center for Unilateral Retinoblastoma

Genetic Tests for Unilateral Retinoblastoma

Anatomical Context for Unilateral Retinoblastoma

MalaCards organs/tissues related to Unilateral Retinoblastoma:

39
Eye, Pineal

Publications for Unilateral Retinoblastoma

Articles related to Unilateral Retinoblastoma:

(show top 50) (show all 68)
id Title Authors Year
1
Unilateral Retinoblastoma Managed With Intravenous Chemotherapy Versus Intra-Arterial Chemotherapy. Outcomes Based on the International Classification of Retinoblastoma. ( 26765038 )
2016
2
Advanced unilateral retinoblastoma: a case of sparing enucleation treatment failure. ( 27085272 )
2016
3
Maternal diet during pregnancy and unilateral retinoblastoma. ( 25542139 )
2015
4
Advanced Unilateral Retinoblastoma: The Impact of Ophthalmic Artery Chemosurgery on Enucleation Rate and Patient Survival at MSKCC. ( 26709699 )
2015
5
Uncommon RB1 somatic mutations in a unilateral retinoblastoma patient. ( 26117602 )
2015
6
Mutation spectrum of RB1 gene in unilateral retinoblastoma cases from Tunisia and correlations with clinical features. ( 25602518 )
2015
7
Pathologic risk-based adjuvant chemotherapy for unilateral retinoblastoma following enucleation. ( 24577551 )
2014
8
Clinical treatment and prognostic observation for different pathological infiltrations in 537 patients with unilateral retinoblastoma. ( 25316233 )
2014
9
From a Suspicious Cystic Pineal Gland to Pineoblastoma in a Patient with Familial Unilateral Retinoblastoma. ( 24940935 )
2014
10
Results of a multicenter prospective study on the postoperative treatment of unilateral retinoblastoma after primary enucleation. ( 23460706 )
2013
11
Sporadic unilateral retinoblastoma or first sign of bilateral disease? ( 23355526 )
2013
12
Multiple atypical recurrent meningiomas 13 years after radiotherapy for unilateral retinoblastoma: case report and review of the literature. ( 23487298 )
2013
13
Enucleated eyes after failed intra-arterial infusion of chemotherapy for unilateral retinoblastoma: histopathologic evaluation of vitreous seeding. ( 22174572 )
2011
14
Ewing's sarcoma as second malignancy following a short latency in unilateral retinoblastoma. ( 21826516 )
2011
15
A 20.5-Mb germline deletion of 13q13.1-->q14.3 and somatic mutations of the RB1 gene in an 8-year-old girl with unilateral retinoblastoma, developmental delay and mental retardation. ( 22303805 )
2011
16
Unilateral retinoblastoma in an eye with Peters anomaly. ( 20451864 )
2010
17
Results of a prospective study for the treatment of unilateral retinoblastoma. ( 20486172 )
2010
18
Management and outcome of unilateral retinoblastoma. ( 20006813 )
2009
19
Molecular karyotype of sporadic unilateral retinoblastoma tumors. ( 19491728 )
2009
20
Some clinical findings at presentation can predict high-risk pathology features in unilateral retinoblastoma. ( 19415010 )
2009
21
Ki-67 cell proliferation in familial and in esporadic unilateral retinoblastoma: case report. ( 17589712 )
2007
22
Comparison of orbital volumes in enucleated patients with unilateral retinoblastoma: hydroxyapatite implants versus silicone implants. ( 17881992 )
2007
23
Unilateral retinoblastoma, lack of familial history and older age does not exclude germline RB1 gene mutation. ( 16343894 )
2006
24
Age at diagnosis of isolated unilateral retinoblastoma does not distinguish patients with and without a constitutional RB1 gene mutation but is influenced by a parent-of-origin effect. ( 15763650 )
2005
25
Neoadjuvant chemotherapy for extensive unilateral retinoblastoma. ( 12598448 )
2003
26
Leydig cell tumor and mature teratoma: unusual non-ocular tumors associated with sexual pseudo-precocity six years after unilateral retinoblastoma. ( 11920800 )
2002
27
Brief report: conservative treatment in unilateral retinoblastoma: a preliminary report. ( 11984807 )
2002
28
Chemoreduction for unilateral retinoblastoma. ( 12470138 )
2002
29
Electroretinographic changes in the inner retinal layers of the retained eyes of patients with sporadic unilateral retinoblastoma. ( 12187428 )
2002
30
Evaluation of chemoprophylaxis in patients with unilateral retinoblastoma with high-risk features on histopathologic examination. ( 11146725 )
2001
31
Isolated granulocytic myelodysplasia in a child with unilateral retinoblastoma. ( 11020113 )
2000
32
Mutation of the RB1 gene caused unilateral retinoblastoma in early Age. ( 10812163 )
2000
33
Is screening for primitive neuroectodermal tumors in patients with unilateral retinoblastoma necessary? ( 10675872 )
2000
34
Metachronous tumor development in unilateral retinoblastoma. ( 10887927 )
2000
35
A constitutional homozygous mutation in the RB1 gene in a patient with unilateral retinoblastoma. ( 10991691 )
2000
36
RB1 gene mutations in peripheral blood DNA of patients with isolated unilateral retinoblastoma. ( 9973307 )
1999
37
No association between the presence of a constitutional RB1 gene mutation and age in 68 patients with isolated unilateral retinoblastoma. ( 10533490 )
1999
38
Frequency and nature of germline Rb-1 gene mutations in a series of patients with sporadic unilateral retinoblastoma. ( 10673998 )
1999
39
Unilateral retinoblastoma with acquired monosomy 7 and secondary acute myelomonocytic leukemia. ( 9689935 )
1998
40
Age at diagnosis to discriminate those patients for whom constitutional DNA sequencing is appropriate in sporadic unilateral retinoblastoma. ( 10023315 )
1998
41
Unilateral retinoblastoma in an adult. ( 9373097 )
1997
42
Unilateral retinoblastoma in an adult: report of a case and review of the literature. ( 9022103 )
1997
43
Unilateral retinoblastoma in adults. ( 9261300 )
1997
44
Cerebral primitive neuro-ectodermal tumour following treatment of a unilateral retinoblastoma. ( 9309290 )
1997
45
Constitutional RB1-gene mutations in patients with isolated unilateral retinoblastoma. ( 9311732 )
1997
46
Unilateral retinoblastoma--genetic implications. ( 8703851 )
1996
47
Nasopharyngeal osteosarcoma as second malignant neoplasm in a post-treated unilateral retinoblastoma: report of a case and review of literature. ( 8839078 )
1996
48
Parents with unilateral retinoblastoma: their affected children. ( 8703854 )
1996
49
Deletion of Rb1 gene in late osteosarcoma from survivor of unilateral retinoblastoma--a case report. ( 8703379 )
1996
50
Constitutional nonsense germline mutations in the RB1 gene detected in patients with early onset unilateral retinoblastoma. ( 8983285 )
1996

Variations for Unilateral Retinoblastoma

Expression for Unilateral Retinoblastoma

Search GEO for disease gene expression data for Unilateral Retinoblastoma.

Pathways for Unilateral Retinoblastoma

GO Terms for Unilateral Retinoblastoma

Cellular components related to Unilateral Retinoblastoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 nucleoplasm GO:0005654 9.35 DHFR HDAC9 RB1 RBL1 XPO5
2 transcription factor complex GO:0005667 8.8 HDAC9 RB1 RBL1

Biological processes related to Unilateral Retinoblastoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 covalent chromatin modification GO:0016569 9.33 HDAC9 RB1 RBL1
2 neuron differentiation GO:0030182 9.32 HDAC9 RB1
3 regulation of cell cycle GO:0051726 9.26 RB1 RBL1
4 regulation of transcription involved in G1/S transition of mitotic cell cycle GO:0000083 8.96 DHFR RB1
5 regulation of lipid kinase activity GO:0043550 8.62 RB1 RBL1

Molecular functions related to Unilateral Retinoblastoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 mRNA binding GO:0003729 8.96 DHFR XPO5
2 transcription factor binding GO:0008134 8.8 HDAC9 RB1 RBL1

Sources for Unilateral Retinoblastoma

3 CDC
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9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
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28 GO
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33 ICD10
34 ICD10 via Orphanet
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48 NDF-RT
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60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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