MCID: URC004
MIFTS: 16

Urachal Cancer malady

Categories: Rare diseases, Cancer diseases

Aliases & Classifications for Urachal Cancer

Aliases & Descriptions for Urachal Cancer:

Name: Urachal Cancer 50 69
Urachal Carcinoma 50

Classifications:



Summaries for Urachal Cancer

NIH Rare Diseases : 50 urachal cancer is a type of bladder cancer, making up less than 1% of all bladder cancers. the urachus is a structure normally only present during development in the womb that connects the bellybutton and the bladder. this connection normally disappears before birth, but in some people remains. urachal cancers are usually diagnosed in adults in their 50's and 60's and may develop at the dome or anterior wall of the bladder, along the midline of the body (including the belly button), and between the pubis symphasis and the bladder. most urachal cancers are adenocarcinomas (cancers that develop from gland cells). others may be sarcomas (which develop from connective tissue - such as leiomyosarcoma, rhabdomyosarcoma, and malignant fibrous histiocytoma), small cell carcinomas, transitional cell cancer, and mixed neoplasias. most individuals with urachal cancer have symptoms of with hematuria (blood in urine). other symptoms may include abdominal pain, a palpable abdominal mass, mucinuria, and bacteriuria. treatment usually involved surgery to remove the cancer. last updated: 4/11/2017

MalaCards based summary : Urachal Cancer, also known as urachal carcinoma, is related to bladder urachal carcinoma and fasciitis. An important gene associated with Urachal Cancer is CEACAM5 (Carcinoembryonic Antigen Related Cell Adhesion Molecule 5). The drugs Cisplatin and Gemcitabine have been mentioned in the context of this disorder. Affiliated tissues include colon.

Wikipedia : 71 Urachal cancer is a very rare type of cancer arising from the urachus or its remnants. The disease might... more...

Related Diseases for Urachal Cancer

Diseases related to Urachal Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

id Related Disease Score Top Affiliating Genes
1 bladder urachal carcinoma 11.9
2 fasciitis 9.7
3 urachal diverticulum 9.6

Symptoms & Phenotypes for Urachal Cancer

Drugs & Therapeutics for Urachal Cancer

Drugs for Urachal Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved Phase 2 15663-27-1 84093 441203 2767
2
Gemcitabine Approved Phase 2 95058-81-4 60750
3
Fluorouracil Approved Phase 2 51-21-8 3385
4
Levoleucovorin Approved Phase 2 68538-85-2
5
leucovorin Approved, Nutraceutical Phase 2 58-05-9 54575, 6560146 143
6 Anti-Infective Agents Phase 2
7 Immunosuppressive Agents Phase 2
8 Antimetabolites Phase 2
9 Antimetabolites, Antineoplastic Phase 2
10 Antiviral Agents Phase 2
11 tyrosine Nutraceutical Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase
1 Fluorouracil, Leucovorin, Gemcitabine, and Cisplatin in Treating Patients With Metastatic or Unresectable Adenocarcinoma of the Urothelium or Urachal Remnant Active, not recruiting NCT00082706 Phase 2
2 Cabozantinib for Advanced Urothelial Cancer Active, not recruiting NCT01688999 Phase 2
3 Umbilical Pilonidal Sinus: a Case Report Completed NCT03007173

Search NIH Clinical Center for Urachal Cancer

Genetic Tests for Urachal Cancer

Anatomical Context for Urachal Cancer

MalaCards organs/tissues related to Urachal Cancer:

39
Colon

Publications for Urachal Cancer

Articles related to Urachal Cancer:

(show all 17)
id Title Authors Year
1
A Case of Metastatic Urachal Cancer Including a Neuroendocrine Component Treated with Gemcitabine, Cisplatin and Paclitaxel Combination Chemotherapy. ( 27339213 )
2016
2
Incidentally discovered urachal cancer in a patient with necrotising fasciitis of the abdominal wall. ( 27118740 )
2016
3
Genetics and biological markers in urachal cancer. ( 27785422 )
2016
4
Clinical outcome of urachal cancer in Japanese patients. ( 26138265 )
2015
5
Urachal Cancer: contemporary review of the pathological, surgical, and prognostic aspects of this rare disease. ( 26583595 )
2015
6
A Case of Urachal Malacoplakia that Seems Like Urachal Cancer. ( 25759783 )
2015
7
Urachal cancer with direct caecal invasion: differential diagnosis from primary colon cancer. ( 24903722 )
2014
8
Prognostic factors for urachal cancer: a bayesian model-averaging approach. ( 25237458 )
2014
9
Treatment outcome and relevance of palliative chemotherapy in urachal cancer. ( 25471123 )
2014
10
Modified FOLFOX6 chemotherapy in patients with metastatic urachal cancer. ( 24969043 )
2013
11
Response of recurrent urachal cancer to gemcitabine and cisplatin therapy: a case report and literature review. ( 21737660 )
2011
12
Metastatic urachal cancer responding to FOLFOX chemotherapy. ( 20398453 )
2010
13
Predictors of survival from urachal cancer: a Mayo Clinic study of 49 cases. ( 17932892 )
2007
14
Irinotecan as a new agent for urachal cancer. ( 16601395 )
2006
15
Urachal cancer: role of conservative surgery. ( 8256396 )
1993
16
Urachal cancer. ( 3842640 )
1985
17
Computed tomography and ultrasound of a urachal cancer. ( 2998529 )
1985

Variations for Urachal Cancer

Cosmic variations for Urachal Cancer:

9
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA Conf
1 COSM45297 TP53 urinary tract,bladder,carcinoma,adenocarcinoma c.810T>G p.F270L 4
2 COSM10790 TP53 urinary tract,bladder,carcinoma,adenocarcinoma c.455C>T p.P152L 4
3 COSM11073 TP53 urinary tract,bladder,carcinoma,adenocarcinoma c.1024C>T p.R342* 4
4 COSM43778 TP53 urinary tract,bladder,carcinoma,adenocarcinoma c.713G>T p.C238F 4
5 COSM10727 TP53 urinary tract,bladder,carcinoma,adenocarcinoma c.438G>A p.W146* 4
6 COSM6932 TP53 urinary tract,bladder,carcinoma,adenocarcinoma c.733G>A p.G245S 4
7 COSM532 KRAS urinary tract,bladder,carcinoma,adenocarcinoma c.38G>A p.G13D 4
8 COSM520 KRAS urinary tract,bladder,carcinoma,adenocarcinoma c.35G>T p.G12V 4
9 COSM125370 urinary tract,bladder,carcinoma,adenocarcinoma c.1633G>A p.E545K 4
10 COSM13016 PTPN11 soft tissue,bladder,rhabdomyosarcoma,embryonal c.226G>C p.E76Q 3

Expression for Urachal Cancer

Search GEO for disease gene expression data for Urachal Cancer.

Pathways for Urachal Cancer

GO Terms for Urachal Cancer

Sources for Urachal Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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