MCID: URC004
MIFTS: 18

Urachal Cancer

Categories: Rare diseases, Cancer diseases

Aliases & Classifications for Urachal Cancer

MalaCards integrated aliases for Urachal Cancer:

Name: Urachal Cancer 49 69
Urachal Carcinoma 49

Classifications:



External Ids:

UMLS 69 C2931202

Summaries for Urachal Cancer

NIH Rare Diseases : 49 Urachal cancer is a type of bladder cancer, making up less than 1% of all bladder cancers. The urachus is a structure normally only present during development in the womb that connects the bellybutton and the bladder. This connection normally disappears before birth, but in some people remains. Urachal cancers are usually diagnosed in adults in their 50's and 60's and may develop at the dome or anterior wall of the bladder, along the midline of the body (including the belly button), and between the pubis symphasis and the bladder. Most urachal cancers are adenocarcinomas (cancers that develop from gland cells). Others may be sarcomas (which develop from connective tissue - such as leiomyosarcoma, rhabdomyosarcoma, and malignant fibrous histiocytoma), small cell carcinomas, transitional cell cancer, and mixed neoplasias. Most individuals with urachal cancer have symptoms of with hematuria (blood in urine). Other symptoms may include abdominal pain, a palpable abdominal mass, mucinuria, and bacteriuria. Treatment usually involved surgery to remove the cancer. Last updated: 4/11/2017

MalaCards based summary : Urachal Cancer, also known as urachal carcinoma, is related to bladder urachal carcinoma and fasciitis. An important gene associated with Urachal Cancer is CEACAM5 (Carcinoembryonic Antigen Related Cell Adhesion Molecule 5). The drugs Cisplatin and Gemcitabine have been mentioned in the context of this disorder. Affiliated tissues include colon.

Wikipedia : 72 Urachal cancer is a very rare type of cancer arising from the urachus or its remnants. The disease might... more...

Related Diseases for Urachal Cancer

Diseases related to Urachal Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 bladder urachal carcinoma 12.0
2 fasciitis 9.7
3 urachal diverticulum 9.7

Symptoms & Phenotypes for Urachal Cancer

Drugs & Therapeutics for Urachal Cancer

Drugs for Urachal Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved Phase 2 15663-27-1 2767 441203 84093
2
Gemcitabine Approved Phase 2 95058-81-4 60750
3
Fluorouracil Approved Phase 2 51-21-8 3385
4
Levoleucovorin Approved, Investigational Phase 2 68538-85-2
5
leucovorin Approved, Nutraceutical Phase 2 58-05-9 143 6006
6 Anti-Infective Agents Phase 2
7 Immunosuppressive Agents Phase 2
8 Antimetabolites Phase 2
9 Antimetabolites, Antineoplastic Phase 2
10 Antiviral Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Fluorouracil, Leucovorin, Gemcitabine, and Cisplatin in Treating Patients With Metastatic or Unresectable Adenocarcinoma of the Urothelium or Urachal Remnant Active, not recruiting NCT00082706 Phase 2 5-Fluorouracil (5-FU);Leucovorin;Cisplatin;Gemcitabine

Search NIH Clinical Center for Urachal Cancer

Genetic Tests for Urachal Cancer

Anatomical Context for Urachal Cancer

MalaCards organs/tissues related to Urachal Cancer:

38
Colon

Publications for Urachal Cancer

Articles related to Urachal Cancer:

(show all 18)
# Title Authors Year
1
Telomerase reverse transcriptase (TERT) promoter mutations are rare in urachal cancer. ( 29047227 )
2017
2
Genetics and biological markers in urachal cancer. ( 27785422 )
2016
3
A Case of Metastatic Urachal Cancer Including a Neuroendocrine Component Treated with Gemcitabine, Cisplatin and Paclitaxel Combination Chemotherapy. ( 27339213 )
2016
4
Incidentally discovered urachal cancer in a patient with necrotising fasciitis of the abdominal wall. ( 27118740 )
2016
5
A Case of Urachal Malacoplakia that Seems Like Urachal Cancer. ( 25759783 )
2015
6
Clinical outcome of urachal cancer in Japanese patients. ( 26138265 )
2015
7
Urachal Cancer: contemporary review of the pathological, surgical, and prognostic aspects of this rare disease. ( 26583595 )
2015
8
Urachal cancer with direct caecal invasion: differential diagnosis from primary colon cancer. ( 24903722 )
2014
9
Treatment outcome and relevance of palliative chemotherapy in urachal cancer. ( 25471123 )
2014
10
Prognostic factors for urachal cancer: a bayesian model-averaging approach. ( 25237458 )
2014
11
Modified FOLFOX6 chemotherapy in patients with metastatic urachal cancer. ( 24969043 )
2013
12
Response of recurrent urachal cancer to gemcitabine and cisplatin therapy: a case report and literature review. ( 21737660 )
2011
13
Metastatic urachal cancer responding to FOLFOX chemotherapy. ( 20398453 )
2010
14
Predictors of survival from urachal cancer: a Mayo Clinic study of 49 cases. ( 17932892 )
2007
15
Irinotecan as a new agent for urachal cancer. ( 16601395 )
2006
16
Urachal cancer: role of conservative surgery. ( 8256396 )
1993
17
Computed tomography and ultrasound of a urachal cancer. ( 2998529 )
1985
18
Urachal cancer. ( 3842640 )
1985

Variations for Urachal Cancer

Cosmic variations for Urachal Cancer:

9 (show all 36)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA Conf
1 COSM2114555 WT1 urinary tract,bladder,carcinoma,adenocarcinoma c.847G>A p.G283R 4
2 COSM6191549 WT1 urinary tract,bladder,carcinoma,adenocarcinoma c.1282T>C p.S428P 4
3 COSM43778 TP53 urinary tract,bladder,carcinoma,adenocarcinoma c.713G>T p.C238F 4
4 COSM11496 TP53 urinary tract,bladder,carcinoma,adenocarcinoma c.476C>A p.A159D 4
5 COSM10648 TP53 urinary tract,bladder,carcinoma,adenocarcinoma c.524G>A p.R175H 4
6 COSM10727 TP53 urinary tract,bladder,carcinoma,adenocarcinoma c.438G>A p.W146* 4
7 COSM10834 TP53 urinary tract,bladder,carcinoma,adenocarcinoma c.711G>A p.M237I 4
8 COSM6932 TP53 urinary tract,bladder,carcinoma,adenocarcinoma c.733G>A p.G245S 4
9 COSM10870 TP53 urinary tract,bladder,carcinoma,adenocarcinoma c.523C>G p.R175G 4
10 COSM10656 TP53 urinary tract,bladder,carcinoma,adenocarcinoma c.742C>T p.R248W 4
11 COSM45297 TP53 urinary tract,bladder,carcinoma,adenocarcinoma c.810T>G p.F270L 4
12 COSM11073 TP53 urinary tract,bladder,carcinoma,adenocarcinoma c.1024C>T p.R342* 4
13 COSM10659 TP53 urinary tract,bladder,carcinoma,adenocarcinoma c.817C>T p.R273C 4
14 COSM10790 TP53 urinary tract,bladder,carcinoma,adenocarcinoma c.455C>T p.P152L 4
15 COSM10663 TP53 urinary tract,bladder,carcinoma,adenocarcinoma c.916C>T p.R306* 4
16 COSM14169 SMAD4 urinary tract,bladder,carcinoma,adenocarcinoma c.988G>A p.E330K 4
17 COSM373800 SMAD4 urinary tract,bladder,carcinoma,adenocarcinoma c.1052A>G p.D351G 4
18 COSM14122 SMAD4 urinary tract,bladder,carcinoma,adenocarcinoma c.1082G>A p.R361H 4
19 COSM763 PIK3CA urinary tract,bladder,carcinoma,adenocarcinoma c.1633G>A p.E545K 4
20 COSM585 NRAS urinary tract,bladder,carcinoma,adenocarcinoma c.183A>T p.Q61H 4
21 COSM517 KRAS urinary tract,bladder,carcinoma,adenocarcinoma c.34G>A p.G12S 4
22 COSM553 KRAS urinary tract,bladder,carcinoma,adenocarcinoma c.182A>T p.Q61L 4
23 COSM520 KRAS urinary tract,bladder,carcinoma,adenocarcinoma c.35G>T p.G12V 4
24 COSM532 KRAS urinary tract,bladder,carcinoma,adenocarcinoma c.38G>A p.G13D 4
25 COSM521 KRAS urinary tract,bladder,carcinoma,adenocarcinoma c.35G>A p.G12D 4
26 COSM19404 KRAS urinary tract,bladder,carcinoma,adenocarcinoma c.436G>A p.A146T 4
27 COSM19900 KRAS urinary tract,bladder,carcinoma,adenocarcinoma c.437C>T p.A146V 4
28 COSM518 KRAS urinary tract,bladder,carcinoma,adenocarcinoma c.34G>C p.G12R 4
29 COSM6191368 CBL urinary tract,bladder,carcinoma,adenocarcinoma c.2520T>G p.C840W 4
30 COSM476 BRAF urinary tract,bladder,carcinoma,adenocarcinoma c.1799T>A p.V600E 4
31 COSM6191378 APC urinary tract,bladder,carcinoma,adenocarcinoma c.1061C>G p.P354R 4
32 COSM6168530 APC urinary tract,bladder,carcinoma,adenocarcinoma c.1252G>A p.E418K 4
33 COSM6191422 APC urinary tract,bladder,carcinoma,adenocarcinoma c.3331G>T p.E1111* 4
34 COSM6191379 APC urinary tract,bladder,carcinoma,adenocarcinoma c.1249T>A p.C417S 4
35 COSM125370 urinary tract,bladder,carcinoma,adenocarcinoma c.1633G>A p.E545K 4
36 COSM13016 PTPN11 soft tissue,bladder,rhabdomyosarcoma,embryonal c.226G>C p.E76Q 3

Expression for Urachal Cancer

Search GEO for disease gene expression data for Urachal Cancer.

Pathways for Urachal Cancer

GO Terms for Urachal Cancer

Sources for Urachal Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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