MCID: URM002
MIFTS: 56

Uremia malady

Nephrological diseases category

Summaries for Uremia

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63Wikipedia, 32MalaCards
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Wikipedia:63 Uremia or uraemia (see spelling differences) is the illness accompanying kidney failure (also called... more...

MalaCards: Uremia, also known as uremia of renal origin, is related to atherosclerosis and hyperparathyroidism. An important gene associated with Uremia is EPO (erythropoietin), and among its related pathways is Osteoblast Signaling. The drugs activated charcoal and charcoal and the compounds tyrosine and calcium have been mentioned in the context of this disorder. Affiliated tissues include kidney, endothelial and bone, and related mouse phenotypes are immune system and hematopoietic system.

Aliases & Classifications for Uremia

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8Disease Ontology, 44Novoseek, 60UMLS, 34MeSH, 56SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological diseases


Aliases & Descriptions:

uremia 8 44 60
uremia of renal origin 8
uremia nos 8


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Disease Ontology8 DOID:4676
MeSH34 D014511

Related Diseases for Uremia

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17GeneCards, 18GeneDecks
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Diseases related to Uremia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 178)
idRelated DiseaseScoreTop Affiliating Genes
1atherosclerosis30.7CASR, TNFRSF11B, APOC3, ITGAM, AOC3, AGER
2hyperparathyroidism30.7CASR, TNFRSF11B, MEN1, NR1I3, EPO, PTH
3hypertension30.6PTH, RETN
4hepatitis30.5IGFBP2, AHSG
5hyperhomocysteinemia30.3RHD
6vascular disease30.3TNFRSF11B, ITGAM, AOC3, AGER, OXA1L, RETN
7renal osteodystrophy30.3CASR, TNFRSF11B, PTH
8hyperphosphatemia30.3PTH, AHSG, TNFRSF11B, CASR
9diabetes mellitus30.0APOC3, CASR, AMBP, ITGAM, AOC3, PTH
10rheumatoid arthritis30.0AMBP, TNFRSF11B, ITGAM, AGER, OXA1L, PF4
11arthritis30.0AMBP, TNFRSF11B, ITGAM, AOC3, AGER, RETN
12pancreatitis30.0CASR, TPMT
13hepatocellular carcinoma30.0MEN1, AOC3, NR1I3, OXA1L, AHSG
14osteomalacia30.0CASR, TNFRSF11B, PTH
15diabetic nephropathy30.0AMBP, AGER, OXA1L, EPO
16glomerulonephritis30.0AMBP, OXA1L
17thrombocytopenia30.0TPMT, PF4, EPO
18obesity29.7APOC3, AOC3, NR1I3, AGER, IGFBP2, AHSG
19myocardial infarction29.7APOC3, ITGAM, AGER, OXA1L, PF4, RETN
20type 2 diabetes mellitus29.7AMBP, APOC3, AOC3, AGER, OXA1L, GLO1
21liver cirrhosis29.7AOC3, OXA1L, AHSG, RETN
22primary hyperparathyroidism29.7PTH, NR1I3, MEN1, CASR
23ischemia29.7TNFRSF11B, IGFBP2, OXA1L, PF4
24osteoarthritis29.7TNFRSF11B, AGER, IGFBP2, RETN
25essential hypertension29.7AGER, PF4, RETN
26coronary artery disease29.7TNFRSF11B, APOC3, AGER, PF4, RETN
27parathyroid carcinoma29.7CASR, MEN1, PTH
28osteosclerosis29.7TNFRSF11B, IGFBP2, PTH
29acromegaly29.7RETN, IGFBP2, MEN1
30adenoma29.7CASR, MEN1, NR1I3, IGFBP2, PTH
31hepatitis b29.7OXA1L, RHD
32parathyroid adenoma29.7PTH, MEN1, CASR
33acute pancreatitis29.7ITGAM, RETN
34rickets29.7CASR, PTH
35peritonitis10.3
36anuria10.2
37metabolic acidosis10.1
38kidney disease10.1
39nephrosclerosis10.1
40hepatitis a10.1
41arteriosclerosis10.1
42malignant hypertension10.1
43vitiligo mental retardation facial dysmorphism uremia10.1
44chronic kidney failure10.0NR1I3, IGFBP2, OXA1L, EPO, PF4, RETN
45secondary hyperparathyroidism of renal origin10.0CASR, TNFRSF11B, MEN1, NR1I3, EPO, PTH
46leukemia10.0MEN1, ITGAM, RHD, IGFBP2, OXA1L, GLO1
47breast cancer10.0AMBP, CASR, TNFRSF11B, APOC3, MEN1, NR1I3
48osteoporosis10.0IGFBP2, AGER, NR1I3, TNFRSF11B, CASR, AHSG
49myeloma10.0TNFRSF11B, ITGAM, RHD, OXA1L, EPO, PF4
50galactosemia10.0APOC3, AOC3, NR1I3, OXA1L, RETN, ALAD

Graphical network of the top 20 diseases related to Uremia:



Diseases related to uremia

Clinical Features for Uremia

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Drugs & Therapeutics for Uremia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Uremia

Search CenterWatch for Uremia

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Uremia

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Anatomical Context for Uremia

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32MalaCards
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MalaCards organs/tissues related to Uremia:

32
Kidney, Endothelial, Bone, Brain, Heart, Monocytes, Skeletal muscle, Lung, Smooth muscle, Pancreas, B cells, Liver, Cervix, Colon, Small intestine, Bone marrow, T cells, Adipocyte, Pancreatic islet

Animal Models for Uremia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Uremia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538710.6TNFRSF11B, APOC3, MEN1, ITGAM, AOC3, AGER
2MP:000539710.6TPMT, CASR, TNFRSF11B, APOC3, ITGAM, RHD
3MP:000537610.4RHD, ITGAM, MEN1, APOC3, CASR, NR1I3

Publications for Uremia

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50PubMed
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Articles related to Uremia:

(show top 50)    (show all 597)
idTitleAuthorsYear
1
Indoxyl sulfate signals for rapid mRNA stabilization of Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 2 (CITED2) and suppresses the expression of hypoxia-inducible genes in experimental CKD and uremia. (23792300)
2013
2
Alteration of human blood cell transcriptome in uremia. (23809614)
2013
3
Genome-wide analysis of histone H3 lysine9 trimethylation by ChIP-seq in peripheral blood mononuclear cells of uremia patients. (23621585)
2013
4
Uremia and thrombotic microangiopathy: conditions that may havethe same manifestation. (23362978)
2013
5
Disintegration of colonic epithelial tight junction in uremia: a likely cause of CKD-associated inflammation. (22131233)
2012
6
Gut bacterial translocation contributes to microinflammation in experimental uremia. (22615020)
2012
7
Parathyroid hormone and phosphorus overload in uremia: impact on cardiovascular system. (21825304)
2012
8
Development and prevention of morphologic and ultrastructural changes in uremia-induced hyperplastic parathyroid gland. (21867406)
2011
9
Diuretics induced uremia and nonrecovery of renal function in a patient with acute renal failure caused by sepsis. (22022011)
2011
10
Metabolite profiling identifies markers of uremia. (20378825)
2010
11
Sevelamer carbonate reduces inflammation and endotoxemia in an animal model of uremia. (20861617)
2010
12
Effect of extract of Withania Somnifera on dehydration-induced oxidative stress-related uremia in male rats. (20061697)
2010
13
Cardiovascular effects of uremia in apolipoprotein E-deficient mice. (19939336)
2009
14
Dinucleoside polyphosphates and uremia. (19708989)
2009
15
Vascular calcification in uremia: what is new and where are we going? (18805387)
2008
16
Effect of spironolactone on hypertrophy of left ventricular myocardium in wistar rats with experimental uremia. (19110558)
2008
17
Uremia impairs monocyte and monocyte-derived dendritic cell function in hemodialysis patients. (17728708)
2007
18
Work-induced changes in skeletal muscle IGF-1 and myostatin gene expression in uremia. (16871256)
2006
19
Diffusion-weighted magnetic resonance imaging in the syndrome of acute bilateral basal ganglia lesions in diabetic uremia. (16700013)
2006
20
Proceedings of the 4th International Congress on Uremia Research and Toxicity, Izmir, Turkey, September 14-17, 2006. (16825014)
2006
21
Increased parathyroid hormone gene expression in secondary hyperparathyroidism of experimental uremia is reversed by calcimimetics: correlation with posttranslational modification of the trans acting factor AUF1. (16291838)
2006
22
Brain dysfunction in uremia: a question of cortical hyperexcitability? (15908270)
2005
23
Infective endocarditis developing as uremia. (16020887)
2005
24
Reduced agonist-induced endothelium-dependent vasodilation in uremia is attributable to an impairment of vascular nitric oxide. (15728785)
2005
25
Oral administration of biochemically active microcapsules to treat uremia: new insights into an old approach. (15648574)
2004
26
Oxidative stress in uremia: nature, mechanisms, and potential consequences. (15490413)
2004
27
Uremia causes endothelial progenitor cell deficiency. (15253717)
2004
28
Homocysteine in uremia. (12612968)
2003
29
Skeletal resistance to parathyroid hormone as a background abnormality in uremia. (15012692)
2003
30
Alterations of non-enzymatic biochemistry in uremia, diabetes, and atherosclerosis ("carbonyl stress"). (12508715)
2002
31
Novel erythropoiesis stimulating protein exerts an effect on platelet function in uremia equivalent to that exerted by recombinant human erythropoietin. (12010672)
2002
32
Determination of vitamin C in plasma and dialysate from uremia patients by high performance liquid chromatography with electrochemical detection. (12541974)
2002
33
Calcitriol increases burst forming unit-erythroid (BFU-E) in vitro proliferation in chronic uremia. Synergic effect with DNA recombinant erythropoietin (rHu-Epo)]. (11346713)
2001
34
B lymphopenia in uremia is related to an accelerated in vitro apoptosis and dysregulation of Bcl-2. (10727545)
2000
35
Hemodialysis does not influence the peroxidative state already present in uremia. (11124591)
2000
36
Absence of somatic RET gene mutation in sporadic parathyroid tumors and hyperplasia secondary to uremia, and absence of somatic Men1 gene mutation in MEN2A-associated hyperplasia. (10915003)
2000
37
Introduction to renal osteodystrophy: calcium metabolism in health and uremia. (10372833)
1999
38
Neutrophil apoptosis and dysfunction in uremia. (9890314)
1999
39
Apolipoprotein C-III, hypertriglyceridemia and triglyceride-rich lipoproteins in uremia. (10681649)
1999
40
Double-phase Tc-99m sestamibi scintigraphy in a patient with uremia and secondary hyperparathyroidism: an aid for subtotal parathyroidectomy. (10069733)
1999
41
The use of the artificial kidney in the treatment of uremia. 1952. (9854252)
1998
42
Systemic involvement and uremia in a patient with tuberous sclerosis. (9653840)
1998
43
Effect of serum parathyroid hormone and aluminum levels on the response to erythropoietin in uremia. (9689168)
1998
44
Endothelial cell markers in chronic uremia: relationship with hemostatic defects and severity of renal failure. (9610957)
1997
45
Technical note. The serum concentration of the advanced glycation end-product N epsilon-(carboxymethyl)lysine is increased in uremia. (9328946)
1997
46
Vitamin D receptor alleles b, a, and T: risk factors for sporadic primary hyperparathyroidism (HPT) but not HPT of uremia or MEN 1. (9070272)
1997
47
Enrollment parathyroid hormone level is a new marker of survival in hemodialysis and peritoneal dialysis therapy for uremia. (8957048)
1996
48
Inhibitors of renal epithelial phosphate transport in tumor-induced osteomalacia and uremia. (8608414)
1995
49
Serum lipids predict cardiac death in diabetic patients on maintenance hemodialysis. Results of a prospective study. The German Study Group Diabetes and Uremia. (8341379)
1993
50
Prurigo nodularis and uremia. (1118744)
1975

Genetic Variations for Uremia

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Expression for genes affiliated with Uremia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Uremia

Search GEO for disease gene expression data for Uremia.

Pathways for genes affiliated with Uremia

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37NCBI BioSystems Database
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Pathways related to Uremia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.5PTH, TNFRSF11B

Compounds for genes affiliated with Uremia

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44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Uremia according to GeneCards/GeneDecks:

(show top 50)    (show all 108)
idCompoundScoreTop Affiliating Genes
1tyrosine4411.2TPMT, ALAD, PTH, RETN, PF4, AHSG
2calcium44 49 11 2414.1AGER, ITGAM, AOC3, RHD, TNFRSF11B, IGFBP2
3creatinine4411.1PTH, ALAD, TPMT, RETN, PF4, EPO
4lipid4411.1TNFRSF11B, GLO1, AMBP, RHD, ITGAM, AOC3
5glucose4411.1AMBP, CASR, APOC3, ITGAM, RHD, IGFBP2
6vitamin d4411.1MEN1, NR1I3, TNFRSF11B, CASR, EPO, AHSG
7nitric oxide44 11 2413.1RETN, PTH, AGER, GLO1, CASR, TNFRSF11B
8oxygen44 2412.1RHD, NR1I3, AGER, IGFBP2, EPO, PF4
9fibrinogen4411.0AMBP, AHSG, TNFRSF11B, RETN, APOC3, IGFBP2
10vegf4411.0ITGAM, MEN1, TNFRSF11B, PTH, AGER, RETN
11cholesterol44 28 11 2414.0IGFBP2, PF4, RETN, APOC3, AGER, NR1I3
12calcitriol44 59 11 2414.0CASR, EPO, TNFRSF11B, ITGAM, NR1I3, IGFBP2
13atp44 2812.0GLO1, RHD, PF4, PTH, ALAD, ITGAM
14steroid4411.0TPMT, RETN, PF4, GLO1, NR1I3, IGFBP2
15lysine4411.0RHD, NR1I3, OXA1L, PF4, AOC3, TNFRSF11B
16testosterone44 59 11 2414.0APOC3, PTH, RETN, ALAD, TNFRSF11B, EPO
17serine4411.0AMBP, CASR, RHD, AGER, NR1I3, ITGAM
18cyclosporin a44 28 5913.0TPMT, EPO, NR1I3, ITGAM, TNFRSF11B, CASR
19cysteine4411.0CASR, AMBP, RETN, TNFRSF11B, ITGAM, OXA1L
20p0024411.0TNFRSF11B, RETN, PF4, IGFBP2, ITGAM, APOC3
21thymidine44 2412.0IGFBP2, PTH, PF4, NR1I3, EPO, MEN1
22malondialdehyde4411.0PF4, ALAD, AOC3, AGER, EPO
23sodium44 2412.0NR1I3, AMBP, CASR, PTH, RETN, TNFRSF11B
24ethanol44 49 11 2413.9RHD, ALAD, ITGAM, NR1I3, AHSG, PF4
25estradiol44 11 2412.9ALAD, NR1I3
26superoxide44 2411.9PF4, ALAD, GLO1, ITGAM
27estrogen4410.9APOC3, AHSG
28urea44 11 2412.9RETN, AMBP, TNFRSF11B, GLO1, EPO
29phosphorus4410.9PTH, CASR, TNFRSF11B, NR1I3
30thyroxine44 2411.9TNFRSF11B, PTH, OXA1L, IGFBP2, RETN
31hydroxyproline44 11 2412.9AOC3, TNFRSF11B, PTH, AHSG
32hydroxyapatite4410.9TNFRSF11B, CASR, AMBP, AHSG
33lactate4410.9GLO1, ITGAM, PF4, EPO, AMBP, ALAD
34forskolin44 49 1112.8IGFBP2, RETN, PTH
35dhea4410.8NR1I3, RETN, IGFBP2, TNFRSF11B
36polyacrylamide4410.8RHD, GLO1, AHSG, AMBP, APOC3
37pamidronate44 49 1112.8PTH, CASR, TNFRSF11B
38aprotinin44 1111.8AMBP, EPO, PF4, PTH
39xbai4410.8AHSG, CASR, APOC3
40alanine4410.8CASR, NR1I3, TPMT, AMBP, PF4, RETN
41heparin44 28 11 2413.8ITGAM, PF4, AGER, APOC3, TNFRSF11B
42uric acid44 2411.7ALAD
43aminoguanidine44 28 1112.7EPO, AOC3, OXA1L
44adenylate4410.7RHD, PF4, GLO1, PTH, CASR, ITGAM
45latex4410.7RHD, ITGAM, AMBP, PF4
46sodium dodecylsulfate4410.6AMBP, OXA1L, IGFBP2, RHD
471,25 dihydroxy vitamin d34410.6NR1I3, PTH, CASR, TNFRSF11B
48homocysteine44 2411.5RHD, APOC3, TNFRSF11B, RETN
49l-tryptophan44 28 11 2413.4CASR, NR1I3, OXA1L
50cuprophan4410.2PF4, EPO, ITGAM

GO Terms for genes affiliated with Uremia

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16Gene Ontology
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Cellular components related to Uremia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.6TNFRSF11B, APOC3, AGER, IGFBP2, EPO, AHSG
2extracellular spaceGO:00561510.3PTH, AMBP, TNFRSF11B, APOC3, IGFBP2, EPO

Biological processes related to Uremia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to nutrientGO:00758410.5IGFBP2, APOC3, TNFRSF11B

Molecular functions related to Uremia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00517910.5PTH, RETN, EPO

Products for genes affiliated with Uremia

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Uremia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet