Aliases & Classifications for Uremia

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Sources:
9Disease Ontology, 43Novoseek, 60UMLS, 55SNOMED-CT, 33MeSH
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Uremia, Aliases & Descriptions:

Name: Uremia 9 43 60
 
Uremia of Renal Origin 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological diseases


External Ids:

Disease Ontology9 DOID:4676
MeSH33 D014511

Summaries for Uremia

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Wikipedia:63 Uremia or uraemia (see spelling differences) can be translated as \"urea in the blood\". Urea is one of... more...

MalaCards based summary: Uremia, also known as uremia of renal origin, is related to renal osteodystrophy and hemolytic anemia. An important gene associated with Uremia is EPO (erythropoietin), and among its related pathways are Transcription Role of VDR in regulation of genes involved in osteoporosis and Osteoblast Signaling. The drugs activated charcoal and charcoal and the compounds phenylhydrazine and saci have been mentioned in the context of this disorder. Affiliated tissues include kidney, testes and endothelial, and related mouse phenotypes are liver/biliary system and cellular.

Related Diseases for Uremia

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Diseases related to Uremia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 149)
idRelated DiseaseScoreTop Affiliating Genes
1renal osteodystrophy30.3CASR, PTH, TNFRSF11B
2hemolytic anemia30.3RHD, EPO
3kidney disease30.2CASR, TNFRSF11B, AHSG
4hyperphosphatemia30.1AHSG, TNFRSF11B, PTH, CASR
5rickets30.1PTH, CASR
6hyperparathyroidism30.1TNFRSF11B, PTH, EPO, MEN1, CASR, NR1I3
7acromegaly30.0RETN, MEN1
8atherosclerosis30.0AHSG, TNFRSF11B, APOC3, RETN, CASR
9osteomalacia30.0TNFRSF11B, PTH, CASR
10liver cirrhosis29.9TNFRSF11B, RETN, RHD
11coronary artery disease29.8TNFRSF11B, APOC3, RETN
12obesity29.7AHSG, APOC3, RETN, NR1I3
13primary hyperparathyroidism29.6PTH, MEN1, CASR, NR1I3
14adenoma29.6NR1I3, CASR, MEN1, PTH
15endotheliitis10.4
16hepatitis10.4
17rh isoimmunization10.4RHD, EPO
18peritonitis10.4
19neonatal jaundice10.3RHD, NR1I3
20multiple endocrine neoplasia iia10.3MEN1, PTH
21myelofibrosis10.3AHSG, EPO
22sickle cell disease10.3RHD, EPO
23anuria10.3
24hyperhomocysteinemia10.3
25malaria10.3RHD, ALAD
26hyperostosis, endosteal10.3PTH, TNFRSF11B
27osteoporosis10.2PTH, TNFRSF11B
28spondyloarthropathy 110.2TNFRSF11B, PTH
29pancytopenia10.2EPO, TPMT
30metabolic acidosis10.2
31vitiligo mental retardation facial dysmorphism uremia10.2
32thalassemia, hispanic gamma-delta-beta10.2TNFRSF11B, EPO, RHD
33osteitis fibrosa10.1CASR, PTH
34lipodystrophy10.1RETN, APOC3
35hyperparathyroidism, neonatal10.1NR1I3, CASR
36calcinosis10.1CASR, PTH
37nephrosclerosis10.1
38cerebritis10.1
39arteriosclerosis10.1
40malignant hypertension10.1
41autonomic dysfunction10.1
42hyperparathyroidism-jaw tumor syndrome10.1MEN1, CASR
43myeloma10.1TNFRSF11B, EPO, RHD
44nephrocalcinosis10.1CASR, NR1I3
45gastrinoma10.1CASR, MEN1
46nutritional deficiency disease10.1EPO, RETN
47anorexia nervosa10.1RETN, TNFRSF11B
48rheumatoid arthritis10.0
49hepatocellular carcinoma10.0
50arteriovenous fistula10.0

Graphical network of the top 20 diseases related to Uremia:



Diseases related to uremia

Symptoms for Uremia

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Drugs & Therapeutics for Uremia

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Drug clinical trials:

Search ClinicalTrials for Uremia

Search NIH Clinical Center for Uremia

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Uremia

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Anatomical Context for Uremia

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MalaCards organs/tissues related to Uremia:

31
Kidney, Testes, Endothelial, Bone, Brain, Heart, Neutrophil, Skeletal muscle, Monocytes, Lung, Pancreas, Smooth muscle, Liver, T cells, B cells, Bone marrow, Small intestine, Colon, Adipocyte, Cervix, Pancreatic islet

Animal Models for Uremia or affiliated genes

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MGI Mouse Phenotypes related to Uremia:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053709.0NR1I3, MEN1, RETN, EPO
2MP:00053847.4TNFRSF11B, APOC3, EPO, MEN1, CASR, NR1I3
3MP:00053977.2TNFRSF11B, PTH, APOC3, TPMT, EPO, CASR
4MP:00107687.1TNFRSF11B, PTH, TPMT, EPO, MEN1, CASR
5MP:00053786.8AHSG, TNFRSF11B, PTH, APOC3, TPMT, MEN1
6MP:00053766.3RHD, AHSG, PTH, APOC3, TPMT, EPO

Publications for Uremia

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Articles related to Uremia:

(show top 50)    (show all 617)
idTitleAuthorsYear
1
Intratympanic steroid injection as a first-line therapy in uremia patients with sudden sensorineural hearing loss. (25783847)
2015
2
Serum calcium and bone: effect of PTH, phosphate, vitamin D and uremia. (25259820)
2014
3
Simultaneous pancreas and kidney transplantation for liver transplant recipients with diabetes and uremia. (25457347)
2014
4
Genome-wide analysis of DNA 5-hmC in peripheral blood of uremia by hMeDIP-chip. (24697287)
2014
5
Acute uremia suppresses leucine-induced signal transduction in skeletal muscle. (23783244)
2013
6
Indoxyl sulfate signals for rapid mRNA stabilization of Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 2 (CITED2) and suppresses the expression of hypoxia-inducible genes in experimental CKD and uremia. (23792300)
2013
7
Effects of chronic kidney disease and uremia on hepatic drug metabolism and transport. (24132209)
2013
8
Ghrelin and muscle metabolism in chronic uremia. (22200437)
2012
9
Simultaneous pancreas-kidney transplants are appropriate in insulin-treated candidates with uremia regardless of diabetes type. (21527647)
2011
10
Treatment of cardiovascular calcification in uremia. (21824104)
2011
11
Sex differences in kidney size and clinical features of patients with uremia. (21056871)
2010
12
Ultrastructural analysis of vascular calcifications in uremia. (20203159)
2010
13
ACE inhibition attenuates uremia-induced aortic valve thickening in a novel mouse model. (19257900)
2009
14
C-reactive protein and uremia. (19708997)
2009
15
Severe hemolytic uremia syndrome and antiphospholipid antibodies following bowel infection in the absence of major vascular occlusions: an example of MAPS? (19160952)
2008
16
Uremia-related vascular calcification: more than apatite deposition. (17149373)
2007
17
Brain dysfunction in uremia: a question of cortical hyperexcitability? (15908270)
2005
18
Oxidative stress and uremia. (15660443)
2005
19
IL-10, IL-6, and TNF-alpha: central factors in the altered cytokine network of uremia--the good, the bad, and the ugly. (15780075)
2005
20
Mechanisms of vascular calcification in uremia. (15490398)
2004
21
Monocyte apoptosis in uremia is normalized with continuous blood purification modalities. (14732806)
2004
22
Eating behavior disorders in uremia: a question of balance in appetite regulation. (14717811)
2004
23
Acute uremia produced in rats by nephrotoxic chemicals is alleviated by protein deficient diet. (12911155)
2003
24
Renin-angiotensin gene polymorphism in children with uremia and essential hypertension. (12579405)
2003
25
Efficacy of 19-Nor-1,25-(OH)2D2 in the prevention and treatment of hyperparathyroid bone disease in experimental uremia. (12753289)
2003
26
Homocysteine in uremia. (12612968)
2003
27
Chronic uremia induces permeability changes, increased nitric oxide synthase expression, and structural modifications in the peritoneum. (11562414)
2001
28
MAPnckeberg's medial sclerosis and inorganic phosphate in uremia. (11576921)
2001
29
Coronary artery disease in uremia: Etiology, diagnosis, and therapy. (11737581)
2001
30
Selection bias impacts outcome reports of uremia therapy. (10873894)
2000
31
Serum lipids status in patients with diabetic uremia on 10 years of maintenance hemodialysis. (10412780)
1999
32
Introduction to renal osteodystrophy: calcium metabolism in health and uremia. (10372833)
1999
33
Alterations in nonenzymatic biochemistry in uremia: origin and significance of "carbonyl stress" in long-term uremic complications. (9987064)
1999
34
Medical management of secondary hyperparathyroidism in uremia. (10372838)
1999
35
Modulation of parathyroid cell function by calcium ion in health and uremia. (10372834)
1999
36
Acute movement disorders with bilateral basal ganglia lesions in uremia. (9827621)
1998
37
Imidazolium crosslinks derived from reaction of lysine with glyoxal and methylglyoxal are increased in serum proteins of uremic patients: evidence for increased oxidative stress in uremia. (9637262)
1998
38
Effects of benazepril on insulin resistance and glucose tolerance in uremia. (9725782)
1998
39
Effect of metabolic acidosis on insulin action and secretion in uremia. (9690228)
1998
40
Use of recombinant human erythropoietin outside the setting of uremia. (9192747)
1997
41
The parathyroid-bone axis in uremia: new insights into old questions. (9051353)
1997
42
Enrollment parathyroid hormone level is a new marker of survival in hemodialysis and peritoneal dialysis therapy for uremia. (8957048)
1996
43
Reactivity to hepatitis B vaccination (HBV) in patients with uremia: association with defined HLA antigen configuration and complement protein allotypes C4A, C4B and B factor (Bf)]. (8834646)
1995
44
The rate and control of baseline red cell production in hematologically stable patients with uremia. (7665976)
1995
45
Reduced production, absorption, and elimination of erythropoietin in uremia compared with healthy volunteers. (7993997)
1994
46
Myocardial texture and cardiac calcification in uremia. (8345830)
1993
47
Growth hormone metabolism in uremia. (1777890)
1991
48
Progression to uremia after remission of acute poststreptococcal glomerulonephritis. (787789)
1976
49
The influence of uremia upon renal hypertension. (5438011)
1970
50
Uremia and disseminated platelet-cell (thrombocyte) thrombosis; report of a case due to malignant nephrosclerosis with acute pancreatitis. (14914218)
1952

Variations for Uremia

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Expression for genes affiliated with Uremia

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Search GEO for disease gene expression data for Uremia.

Pathways for genes affiliated with Uremia

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Pathways related to Uremia according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7PTH, TNFRSF11B
29.7PTH, TNFRSF11B

Compounds for genes affiliated with Uremia

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Compounds related to Uremia according to GeneCards Suite gene sharing:

(show top 50)    (show all 71)
idCompoundScoreTop Affiliating Genes
1phenylhydrazine4310.3EPO, RHD
2saci4310.1AHSG, APOC3
3succinylacetone4310.0ALAD, EPO
4zinc protoporphyrin439.9EPO, ALAD
5hydroxyproline43 24 1211.7PTH, TNFRSF11B, AHSG
6gadolinium439.6CASR, NR1I3
7cinacalcet43 28 1211.6CASR, NR1I3
8strontium439.5TNFRSF11B, CASR
9protoporphyrin ix43 24 1211.5ALAD, EPO
10ethanol43 49 24 1212.5RHD, NR1I3, ALAD, AHSG
11dhea439.4TNFRSF11B, RETN, NR1I3
12thymidine43 2410.4PTH, EPO, MEN1, NR1I3
13neomycin439.4EPO, CASR, NR1I3
14azathioprine43 2 49 1212.4EPO, TPMT, TNFRSF11B
15urea43 24 1211.3TNFRSF11B, EPO, RETN
16xbai439.3CASR, APOC3, AHSG
17pamidronate43 49 1211.3CASR, PTH, TNFRSF11B
1825-hydroxyvitamin d439.2CASR, PTH, TNFRSF11B
19iron43 2410.2RHD, ALAD, EPO, TNFRSF11B
20p002439.2TNFRSF11B, APOC3, RETN
21atorvastatin43 49 28 24 1213.2RETN, APOC3, TNFRSF11B
22hydroxyapatite439.2CASR, TNFRSF11B, AHSG
23thyroxine43 2410.2RETN, PTH, TNFRSF11B
24homocysteine43 2410.1RHD, RETN, APOC3, TNFRSF11B
25fibrinogen439.0AHSG, TNFRSF11B, APOC3, RETN
26aspartate439.0RHD, RETN, EPO, TNFRSF11B
27phosphorus438.9TNFRSF11B, PTH, CASR, NR1I3
281,25 dihydroxy vitamin d3438.9TNFRSF11B, PTH, CASR, NR1I3
29inositol 1,4,5 trisphosphate438.9PTH, CASR, NR1I3
30vegf438.8MEN1, RETN, EPO, PTH, TNFRSF11B
31estradiol43 24 1210.8TNFRSF11B, PTH, RETN, ALAD, NR1I3
32calcitriol43 59 24 1211.7TNFRSF11B, PTH, EPO, CASR, NR1I3
33cholesterol43 28 24 1211.6NR1I3, RETN, APOC3, TNFRSF11B
34forskolin43 49 1210.6TNFRSF11B, PTH, RETN, CASR
35magnesium43 24 1210.5TNFRSF11B, PTH, CASR, ALAD, NR1I3
36lysine438.5RHD, NR1I3, ALAD, CASR, TNFRSF11B
37sodium43 249.4TNFRSF11B, PTH, RETN, CASR, NR1I3
38steroid438.4TNFRSF11B, APOC3, TPMT, RETN, NR1I3
39lipid438.3TNFRSF11B, APOC3, RETN, ALAD, NR1I3, RHD
40cyclosporin a43 28 5910.3TNFRSF11B, TPMT, EPO, CASR, NR1I3
41atp43 289.3TNFRSF11B, PTH, APOC3, TPMT, ALAD, RHD
42testosterone43 59 24 1211.1TNFRSF11B, PTH, APOC3, EPO, RETN, ALAD
43serine438.0TNFRSF11B, APOC3, MEN1, CASR, NR1I3, RHD
44nitric oxide43 24 129.9TNFRSF11B, PTH, APOC3, RETN, CASR, ALAD
45glucose437.7AHSG, TNFRSF11B, PTH, APOC3, RETN, CASR
46vitamin d437.6AHSG, TNFRSF11B, PTH, EPO, MEN1, CASR
47estrogen437.3AHSG, TNFRSF11B, PTH, APOC3, RETN, MEN1
48creatinine437.0TNFRSF11B, PTH, APOC3, TPMT, EPO, RETN
49calcium43 49 24 1210.0AHSG, TNFRSF11B, PTH, RETN, MEN1, CASR
50tyrosine435.7RHD, AHSG, TNFRSF11B, PTH, APOC3, TPMT

GO Terms for genes affiliated with Uremia

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Cellular components related to Uremia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055768.6EPO, APOC3, PTH, TNFRSF11B, AHSG
2extracellular spaceGO:00056157.8RETN, AHSG, TNFRSF11B, PTH, APOC3, EPO

Biological processes related to Uremia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1response to estrogenGO:00436279.7EPO, TNFRSF11B
2response to testosteroneGO:00335749.6EPO, TPMT
3skeletal system developmentGO:00015019.4PTH, TNFRSF11B, AHSG
4response to drugGO:00424939.1TNFRSF11B, PTH, APOC3
5G-protein coupled receptor signaling pathwayGO:00071868.6CASR, APOC3, PTH

Molecular functions related to Uremia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00051799.4RETN, EPO, PTH

Products for genes affiliated with Uremia

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Sources for Uremia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet