MCID: URM002
MIFTS: 56

Uremia malady

Nephrological diseases category

Summaries for Uremia

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63Wikipedia, 32MalaCards
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Wikipedia:63 Uremia or uraemia (see spelling differences) is the illness accompanying kidney failure (also called... more...

MalaCards: Uremia, also known as uremia of renal origin, is related to atherosclerosis and hyperparathyroidism. An important gene associated with Uremia is EPO (erythropoietin), and among its related pathways is Osteoblast Signaling. The drugs activated charcoal and charcoal and the compounds tyrosine and calcium have been mentioned in the context of this disorder. Affiliated tissues include kidney, endothelial and bone, and related mouse phenotypes are immune system and hematopoietic system.

Aliases & Classifications for Uremia

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8Disease Ontology, 44Novoseek, 60UMLS, 34MeSH, 56SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological diseases


Aliases & Descriptions:

uremia 8 44 60
uremia of renal origin 8
uremia nos 8


External Ids:

Disease Ontology8 DOID:4676
MeSH34 D014511

Related Diseases for Uremia

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17GeneCards, 18GeneDecks
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Diseases related to Uremia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 178)
idRelated DiseaseScoreTop Affiliating Genes
1atherosclerosis30.7CASR, TNFRSF11B, APOC3, ITGAM, AOC3, AGER
2hyperparathyroidism30.7CASR, TNFRSF11B, MEN1, NR1I3, EPO, PTH
3hypertension30.6PTH, RETN
4hepatitis30.5IGFBP2, AHSG
5hyperhomocysteinemia30.3RHD
6vascular disease30.3TNFRSF11B, ITGAM, AOC3, AGER, OXA1L, RETN
7renal osteodystrophy30.3CASR, TNFRSF11B, PTH
8hyperphosphatemia30.3PTH, AHSG, TNFRSF11B, CASR
9diabetes mellitus30.0APOC3, CASR, AMBP, ITGAM, AOC3, PTH
10rheumatoid arthritis30.0AMBP, TNFRSF11B, ITGAM, AGER, OXA1L, PF4
11arthritis30.0AMBP, TNFRSF11B, ITGAM, AOC3, AGER, RETN
12pancreatitis30.0CASR, TPMT
13hepatocellular carcinoma30.0MEN1, AOC3, NR1I3, OXA1L, AHSG
14osteomalacia30.0CASR, TNFRSF11B, PTH
15diabetic nephropathy30.0AMBP, AGER, OXA1L, EPO
16glomerulonephritis30.0AMBP, OXA1L
17thrombocytopenia30.0TPMT, PF4, EPO
18obesity29.7APOC3, AOC3, NR1I3, AGER, IGFBP2, AHSG
19myocardial infarction29.7APOC3, ITGAM, AGER, OXA1L, PF4, RETN
20type 2 diabetes mellitus29.7AMBP, APOC3, AOC3, AGER, OXA1L, GLO1
21liver cirrhosis29.7AOC3, OXA1L, AHSG, RETN
22primary hyperparathyroidism29.7PTH, NR1I3, MEN1, CASR
23ischemia29.7TNFRSF11B, IGFBP2, OXA1L, PF4
24osteoarthritis29.7TNFRSF11B, AGER, IGFBP2, RETN
25essential hypertension29.7AGER, PF4, RETN
26coronary artery disease29.7TNFRSF11B, APOC3, AGER, PF4, RETN
27parathyroid carcinoma29.7CASR, MEN1, PTH
28osteosclerosis29.7TNFRSF11B, IGFBP2, PTH
29acromegaly29.7RETN, IGFBP2, MEN1
30adenoma29.7CASR, MEN1, NR1I3, IGFBP2, PTH
31hepatitis b29.7OXA1L, RHD
32parathyroid adenoma29.7PTH, MEN1, CASR
33acute pancreatitis29.7ITGAM, RETN
34rickets29.7CASR, PTH
35peritonitis10.3
36anuria10.2
37metabolic acidosis10.1
38kidney disease10.1
39nephrosclerosis10.1
40hepatitis a10.1
41arteriosclerosis10.1
42malignant hypertension10.1
43vitiligo mental retardation facial dysmorphism uremia10.1
44chronic kidney failure10.0NR1I3, IGFBP2, OXA1L, EPO, PF4, RETN
45secondary hyperparathyroidism of renal origin10.0CASR, TNFRSF11B, MEN1, NR1I3, EPO, PTH
46leukemia10.0MEN1, ITGAM, RHD, IGFBP2, OXA1L, GLO1
47breast cancer10.0AMBP, CASR, TNFRSF11B, APOC3, MEN1, NR1I3
48osteoporosis10.0IGFBP2, AGER, NR1I3, TNFRSF11B, CASR, AHSG
49myeloma10.0TNFRSF11B, ITGAM, RHD, OXA1L, EPO, PF4
50galactosemia10.0APOC3, AOC3, NR1I3, OXA1L, RETN, ALAD

Graphical network of the top 20 diseases related to Uremia:



Diseases related to uremia

Clinical Features for Uremia

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Drugs & Therapeutics for Uremia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Uremia

Search CenterWatch for Uremia

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Uremia

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Anatomical Context for Uremia

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32MalaCards
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MalaCards organs/tissues related to Uremia:

32
Kidney, Endothelial, Bone, Brain, Heart, Monocytes, Skeletal muscle, Lung, Smooth muscle, Pancreas, B cells, Liver, Cervix, Colon, Small intestine, Bone marrow, T cells, Adipocyte, Pancreatic islet

Animal Models for Uremia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Uremia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538710.6TNFRSF11B, APOC3, MEN1, ITGAM, AOC3, AGER
2MP:000539710.6TPMT, CASR, TNFRSF11B, APOC3, ITGAM, RHD
3MP:000537610.4RHD, ITGAM, MEN1, APOC3, CASR, NR1I3

Publications for Uremia

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50PubMed
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Articles related to Uremia:

(show top 50)    (show all 597)
idTitleAuthorsYear
1
An ALK translocation positive carcinoma of the lung presenting as uremia due to bilateral renal obstruction. (23914266)
2013
2
NFI_B in the development of endothelial activation and damage in uremia: an in vitro approach. (22937042)
2012
3
Intestinal motility in acute uremia and effects of erythropoietin. (22588810)
2012
4
Markers of uremia and pericardial effusion in peritoneal dialysis. (21853247)
2012
5
Microencapsulated Saccharomyces cerevisiae column bioreactor for potential use in renal failure uremia. (22288841)
2012
6
Biomarkers of chronic inflammatory state in uremia and cardiovascular disease. (22701810)
2012
7
Induction of systemic inflammation and thickening of subepicardiac arteries in an animal model of uremia. (22189803)
2011
8
Effect of medial calcification on vascular function in uremia. (21478480)
2011
9
Differential Effects of Oral Doxercalciferol (HectorolAr) or Paricalcitol (ZemplarAr) in the Cyp27b1-Null Mouse Model of Uremia. (21849802)
2011
10
Cardiovascular remodeling during arteriovenous fistula maturation in a rodent uremia model. (21104672)
2011
11
Ultrastructural analysis of vascular calcifications in uremia. (20203159)
2010
12
Proceedings of the Sixth International Congress on Uremia Research and Toxicity, October 18-19, 2009, Poiana Brasnov, Romania. (21218549)
2010
13
Determination of oxidative stress markers and their importance in early diagnosis of uremia-related complications. (20352004)
2009
14
Lipoprotein lipase disturbances induced by uremia and hemodialysis. (19708998)
2009
15
Effect of uremia on HDL composition, vascular inflammation, and atherosclerosis in wild-type mice. (17686960)
2007
16
Uremia impairs blood dendritic cell function in hemodialysis patients. (17377508)
2007
17
Oxidative stress in uremia: the role of anemia correction. (17130258)
2006
18
Uremia, atherothrombosis and malnutrition: the role of L-arginine-nitric oxide pathway. (16787198)
2006
19
IL-10, IL-6, and TNF-alpha: central factors in the altered cytokine network of uremia--the good, the bad, and the ugly. (15780075)
2005
20
Arteriosclerosis, vascular calcifications and cardiovascular disease in uremia. (16205470)
2005
21
Preload and flow propagation velocity: insight into patients with uremia and different left ventricular systolic function. (16376751)
2005
22
Monocyte apoptosis in uremia is normalized with continuous blood purification modalities. (14732806)
2004
23
Percutaneous maxacalcitol injection therapy regresses hyperplasia of parathyroid and induces apoptosis in uremia. (12911549)
2003
24
The dynamics of morphological changes in the pyloric endocrine cells of rats with uremia. (12056633)
2002
25
Brain atrophy in uremia. Research of the causes and future perspectives. (12372974)
2002
26
Signs of autonomic neuropathy in childhood uremia. (11198598)
2001
27
Albumin is the major plasma protein target of oxidant stress in uremia. (11422772)
2001
28
Metabolic consequences of hyperhomocysteinemia in uremia. (11576929)
2001
29
Relapsing ascites and uremia due to urinary bladder leakage. (11173013)
2001
30
Vascular disease and atherosclerosis in uremia. (11150800)
2001
31
Carnitine metabolism in uremia. (11576925)
2001
32
Mass spectrometric monitoring of albumin in uremia. (11044246)
2000
33
Medical management of secondary hyperparathyroidism in uremia. (10372838)
1999
34
Carbonyl stress: increased carbonyl modification of proteins by autoxidation products of carbohydrates and lipids in uremia. (10466948)
1999
35
Mechanism of increased parathyroid hormone mRNA in experimental uremia: roles of protein RNA binding and RNA degradation. (10589695)
1999
36
Effect of metabolic acidosis on insulin action and secretion in uremia. (9690228)
1998
37
1,25-Dihydroxyvitamin D3 corrects insulin and lipid abnormalities in uremia. (9573552)
1998
38
Effect of desmopressin on protein S and antithrombin III in uremia. (9375836)
1997
39
The gastrointestinal tract in uremia. (11229178)
1997
40
Enhanced nitric oxide synthesis in uremia: implications for platelet dysfunction and dialysis hypotension. (8377388)
1993
41
Acute effect of erythropoietin on catecholamine levels in uremia. (8321376)
1993
42
The circadian rhythm of erythropoietin in subjects with pre-terminal uremia. (1563123)
1992
43
Platelet aggregation during the recombinant human erythropoietin (rHuEPO) treatment of patients with uremia]. (1488323)
1992
44
Relief of pruritus and decreases in plasma histamine concentrations during erythropoietin therapy in patients with uremia. (1545849)
1992
45
The vitamin D/parathyroid hormone axis in the pathogenesis of hypertension and insulin resistance in uremia. (1465050)
1992
46
Activity of type 1 erythrocyte complement receptors in uremia and after renal transplantation. (2254041)
1990
47
Glucose-induced insulin secretion in uremia: effects of aminophylline infusion and glucose loads. (1963648)
1990
48
The influence of uremia upon renal hypertension. (5438011)
1970
49
Experiences in the treatment of surgical patients having anuria and uremia. (13267681)
1955
50
WEEKLY clinicopathological exercises: malignant nephrosclerosis (uremia with base losing nephropathy). (14899643)
1952

Genetic Variations for Uremia

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Expression for genes affiliated with Uremia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Uremia

Search GEO for disease gene expression data for Uremia.

Pathways for genes affiliated with Uremia

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37NCBI BioSystems Database
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Pathways related to Uremia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.5PTH, TNFRSF11B

Compounds for genes affiliated with Uremia

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44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Uremia according to GeneCards/GeneDecks:

(show top 50)    (show all 108)
idCompoundScoreTop Affiliating Genes
1tyrosine4411.2TPMT, ALAD, PTH, RETN, PF4, AHSG
2calcium44 49 11 2414.1AGER, ITGAM, AOC3, RHD, TNFRSF11B, IGFBP2
3creatinine4411.1PTH, ALAD, TPMT, RETN, PF4, EPO
4lipid4411.1TNFRSF11B, GLO1, AMBP, RHD, ITGAM, AOC3
5glucose4411.1AMBP, CASR, APOC3, ITGAM, RHD, IGFBP2
6vitamin d4411.1MEN1, NR1I3, TNFRSF11B, CASR, EPO, AHSG
7nitric oxide44 11 2413.1RETN, PTH, AGER, GLO1, CASR, TNFRSF11B
8oxygen44 2412.1RHD, NR1I3, AGER, IGFBP2, EPO, PF4
9fibrinogen4411.0AMBP, AHSG, TNFRSF11B, RETN, APOC3, IGFBP2
10vegf4411.0ITGAM, MEN1, TNFRSF11B, PTH, AGER, RETN
11cholesterol44 28 11 2414.0IGFBP2, PF4, RETN, APOC3, AGER, NR1I3
12calcitriol44 59 11 2414.0CASR, EPO, TNFRSF11B, ITGAM, NR1I3, IGFBP2
13atp44 2812.0GLO1, RHD, PF4, PTH, ALAD, ITGAM
14steroid4411.0TPMT, RETN, PF4, GLO1, NR1I3, IGFBP2
15lysine4411.0RHD, NR1I3, OXA1L, PF4, AOC3, TNFRSF11B
16testosterone44 59 11 2414.0APOC3, PTH, RETN, ALAD, TNFRSF11B, EPO
17serine4411.0AMBP, CASR, RHD, AGER, NR1I3, ITGAM
18cyclosporin a44 28 5913.0TPMT, EPO, NR1I3, ITGAM, TNFRSF11B, CASR
19cysteine4411.0CASR, AMBP, RETN, TNFRSF11B, ITGAM, OXA1L
20p0024411.0TNFRSF11B, RETN, PF4, IGFBP2, ITGAM, APOC3
21thymidine44 2412.0IGFBP2, PTH, PF4, NR1I3, EPO, MEN1
22malondialdehyde4411.0PF4, ALAD, AOC3, AGER, EPO
23sodium44 2412.0NR1I3, AMBP, CASR, PTH, RETN, TNFRSF11B
24ethanol44 49 11 2413.9RHD, ALAD, ITGAM, NR1I3, AHSG, PF4
25estradiol44 11 2412.9ALAD, NR1I3
26superoxide44 2411.9PF4, ALAD, GLO1, ITGAM
27estrogen4410.9APOC3, AHSG
28urea44 11 2412.9RETN, AMBP, TNFRSF11B, GLO1, EPO
29phosphorus4410.9PTH, CASR, TNFRSF11B, NR1I3
30thyroxine44 2411.9TNFRSF11B, PTH, OXA1L, IGFBP2, RETN
31hydroxyproline44 11 2412.9AOC3, TNFRSF11B, PTH, AHSG
32hydroxyapatite4410.9TNFRSF11B, CASR, AMBP, AHSG
33lactate4410.9GLO1, ITGAM, PF4, EPO, AMBP, ALAD
34forskolin44 49 1112.8IGFBP2, RETN, PTH
35dhea4410.8NR1I3, RETN, IGFBP2, TNFRSF11B
36polyacrylamide4410.8RHD, GLO1, AHSG, AMBP, APOC3
37pamidronate44 49 1112.8PTH, CASR, TNFRSF11B
38aprotinin44 1111.8AMBP, EPO, PF4, PTH
39xbai4410.8AHSG, CASR, APOC3
40alanine4410.8CASR, NR1I3, TPMT, AMBP, PF4, RETN
41heparin44 28 11 2413.8ITGAM, PF4, AGER, APOC3, TNFRSF11B
42uric acid44 2411.7ALAD
43aminoguanidine44 28 1112.7EPO, AOC3, OXA1L
44adenylate4410.7RHD, PF4, GLO1, PTH, CASR, ITGAM
45latex4410.7RHD, ITGAM, AMBP, PF4
46sodium dodecylsulfate4410.6AMBP, OXA1L, IGFBP2, RHD
471,25 dihydroxy vitamin d34410.6NR1I3, PTH, CASR, TNFRSF11B
48homocysteine44 2411.5RHD, APOC3, TNFRSF11B, RETN
49l-tryptophan44 28 11 2413.4CASR, NR1I3, OXA1L
50cuprophan4410.2PF4, EPO, ITGAM

GO Terms for genes affiliated with Uremia

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16Gene Ontology
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Cellular components related to Uremia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.6TNFRSF11B, APOC3, AGER, IGFBP2, EPO, AHSG
2extracellular spaceGO:00561510.3PTH, AMBP, TNFRSF11B, APOC3, IGFBP2, EPO

Biological processes related to Uremia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to nutrientGO:00758410.5IGFBP2, APOC3, TNFRSF11B

Molecular functions related to Uremia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00517910.5PTH, RETN, EPO

Products for genes affiliated with Uremia

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Uremia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet