MCID: URM002
MIFTS: 56

Uremia malady

Nephrological diseases category

Summaries for Uremia

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63Wikipedia, 32MalaCards
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Wikipedia:63 Uremia or uraemia (see spelling differences) is the illness accompanying kidney failure (also called... more...

MalaCards: Uremia, also known as uremia of renal origin, is related to atherosclerosis and hyperparathyroidism. An important gene associated with Uremia is EPO (erythropoietin), and among its related pathways is Osteoblast Signaling. The drugs activated charcoal and charcoal and the compounds tyrosine and calcium have been mentioned in the context of this disorder. Affiliated tissues include kidney, endothelial and bone, and related mouse phenotypes are immune system and hematopoietic system.

Aliases & Classifications for Uremia

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8Disease Ontology, 44Novoseek, 60UMLS, 34MeSH, 56SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological diseases


Aliases & Descriptions:

uremia 8 44 60
uremia of renal origin 8
uremia nos 8


External Ids:

Disease Ontology8 DOID:4676
MeSH34 D014511

Related Diseases for Uremia

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17GeneCards, 18GeneDecks
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Diseases related to Uremia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 178)
idRelated DiseaseScoreTop Affiliating Genes
1atherosclerosis30.7CASR, TNFRSF11B, APOC3, ITGAM, AOC3, AGER
2hyperparathyroidism30.7CASR, TNFRSF11B, MEN1, NR1I3, EPO, PTH
3hypertension30.6PTH, RETN
4hepatitis30.5IGFBP2, AHSG
5hyperhomocysteinemia30.3RHD
6vascular disease30.3TNFRSF11B, ITGAM, AOC3, AGER, OXA1L, RETN
7renal osteodystrophy30.3CASR, TNFRSF11B, PTH
8hyperphosphatemia30.3PTH, AHSG, TNFRSF11B, CASR
9diabetes mellitus30.0APOC3, CASR, AMBP, ITGAM, AOC3, PTH
10rheumatoid arthritis30.0AMBP, TNFRSF11B, ITGAM, AGER, OXA1L, PF4
11arthritis30.0AMBP, TNFRSF11B, ITGAM, AOC3, AGER, RETN
12pancreatitis30.0CASR, TPMT
13hepatocellular carcinoma30.0MEN1, AOC3, NR1I3, OXA1L, AHSG
14osteomalacia30.0CASR, TNFRSF11B, PTH
15diabetic nephropathy30.0AMBP, AGER, OXA1L, EPO
16glomerulonephritis30.0AMBP, OXA1L
17thrombocytopenia30.0TPMT, PF4, EPO
18obesity29.7APOC3, AOC3, NR1I3, AGER, IGFBP2, AHSG
19myocardial infarction29.7APOC3, ITGAM, AGER, OXA1L, PF4, RETN
20type 2 diabetes mellitus29.7AMBP, APOC3, AOC3, AGER, OXA1L, GLO1
21liver cirrhosis29.7AOC3, OXA1L, AHSG, RETN
22primary hyperparathyroidism29.7PTH, NR1I3, MEN1, CASR
23ischemia29.7TNFRSF11B, IGFBP2, OXA1L, PF4
24osteoarthritis29.7TNFRSF11B, AGER, IGFBP2, RETN
25essential hypertension29.7AGER, PF4, RETN
26coronary artery disease29.7TNFRSF11B, APOC3, AGER, PF4, RETN
27parathyroid carcinoma29.7CASR, MEN1, PTH
28osteosclerosis29.7TNFRSF11B, IGFBP2, PTH
29acromegaly29.7RETN, IGFBP2, MEN1
30adenoma29.7CASR, MEN1, NR1I3, IGFBP2, PTH
31hepatitis b29.7OXA1L, RHD
32parathyroid adenoma29.7PTH, MEN1, CASR
33acute pancreatitis29.7ITGAM, RETN
34rickets29.7CASR, PTH
35peritonitis10.3
36anuria10.2
37metabolic acidosis10.1
38kidney disease10.1
39nephrosclerosis10.1
40hepatitis a10.1
41arteriosclerosis10.1
42malignant hypertension10.1
43vitiligo mental retardation facial dysmorphism uremia10.1
44chronic kidney failure10.0NR1I3, IGFBP2, OXA1L, EPO, PF4, RETN
45secondary hyperparathyroidism of renal origin10.0CASR, TNFRSF11B, MEN1, NR1I3, EPO, PTH
46leukemia10.0MEN1, ITGAM, RHD, IGFBP2, OXA1L, GLO1
47breast cancer10.0AMBP, CASR, TNFRSF11B, APOC3, MEN1, NR1I3
48osteoporosis10.0IGFBP2, AGER, NR1I3, TNFRSF11B, CASR, AHSG
49myeloma10.0TNFRSF11B, ITGAM, RHD, OXA1L, EPO, PF4
50galactosemia10.0APOC3, AOC3, NR1I3, OXA1L, RETN, ALAD

Graphical network of the top 20 diseases related to Uremia:



Diseases related to uremia

Clinical Features for Uremia

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Drugs & Therapeutics for Uremia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Uremia

Drug clinical trials:

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Search NIH Clinical Center for Uremia

Search CenterWatch for Uremia

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Uremia

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Anatomical Context for Uremia

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32MalaCards
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MalaCards organs/tissues related to Uremia:

32
Kidney, Endothelial, Bone, Brain, Heart, Monocytes, Skeletal muscle, Lung, Smooth muscle, Pancreas, B cells, Liver, Cervix, Colon, Small intestine, Bone marrow, T cells, Adipocyte, Pancreatic islet

Animal Models for Uremia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Uremia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538710.6IGFBP2, AGER, AOC3, ITGAM, MEN1, APOC3
2MP:000539710.6ITGAM, PF4, EPO, IGFBP2, AGER, RHD
3MP:000537610.4APOC3, MEN1, ITGAM, PF4, RHD, NR1I3

Publications for Uremia

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50PubMed
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Articles related to Uremia:

(show top 50)    (show all 597)
idTitleAuthorsYear
1
Uremia and chronic kidney disease: the role of the gut microflora and therapies with pro- and prebiotics. (23450842)
2013
2
Natural killer cell dysfunction in uremia: the role of oxidative stress and the effects of dialysis. (23676830)
2013
3
Carbamoylated free amino acids in uremia: HOCl generates volatile protein modifying and cytotoxic oxidant species from N-carbamoyl-threonine but not threonine. (22776434)
2012
4
Effect of uremia on semen quality and reproductive function in humans. (21826526)
2012
5
Proceedings of the Seventh International Congress on Uremia Research and Toxicity, May 12-14, 2011, Nagoya, Japan. (22548223)
2012
6
Proinflammatory CD14+CD16+ monocytes are associated with microinflammation in patients with type 2 diabetes mellitus and diabetic nephropathy uremia. (21847775)
2012
7
Contribution of high flux membranes to the therapy of uremia-associated dyslipidemia. (23190521)
2012
8
Uremia induces functional incompetence of bone marrow-derived stromal cells. (21622994)
2012
9
Uremia research and toxicity. (22200418)
2012
10
Treg/Th17 functional disequilibrium in Chinese uremia on hemodialysis: a link between calcification and cardiovascular disease. (22503035)
2012
11
Treatment of cardiovascular calcification in uremia. (21824104)
2011
12
Plasma protein carbonylation in chronic uremia. (21607919)
2011
13
New insights into uremia-induced alterations in metabolic pathways. (21885966)
2011
14
Sex differences in kidney size and clinical features of patients with uremia. (21056871)
2010
15
Effects of anemia and uremia and a combination of both on cardiovascular structures. (20628260)
2010
16
Proteomic profiling of uremia in serum using magnetic bead-based sample fractionation and MALDI-TOF MS. (20954974)
2010
17
ACE inhibition attenuates uremia-induced aortic valve thickening in a novel mouse model. (19257900)
2009
18
Cleveland Clinic workshop on innovation in treatment of uremia: an introduction to the proceedings. (20017827)
2009
19
Low-dose growth hormone is cardioprotective in uremia. (18650479)
2008
20
Plasma protein homocysteinylation in uremia. (17937608)
2007
21
Protein carbamylation links inflammation, smoking, uremia and atherogenesis. (17828273)
2007
22
Iron supplementation and oxidative stress in patients with uremia. (18175664)
2007
23
Thrombocytopathy and blood complications in uremia]. (16773479)
2006
24
Insufficiency of PTH action on bone in uremia. (16810309)
2006
25
Oxidative stress and uremia. (15660443)
2005
26
Fetuin-A and extraosseous calcification in uremia. (15931001)
2005
27
Mechanisms of enhanced carbohydrate and lipid metabolism in adipose tissue in uremia. (15648028)
2005
28
Eating behavior disorders in uremia: a question of balance in appetite regulation. (14717811)
2004
29
Oxidative stress in uremia. (14564195)
2003
30
Deficiencies of calcium-regulatory proteins in dialysis patients: a novel concept of cardiovascular calcification in uremia. (12694317)
2003
31
Sevelamer hydrochloride attenuates kidney and cardiovascular calcifications in long-term experimental uremia. (14531797)
2003
32
Mitochondrial DNA mutations and oxidative damage in skeletal muscle of patients with chronic uremia. (12372993)
2002
33
Plasma thrombopoietin level and its influence on megakaryocytopoiesis in end-stage liver cirrhosis and uremia patients]. (12513730)
2002
34
MAPnckeberg's medial sclerosis and inorganic phosphate in uremia. (11576921)
2001
35
Inflammation and advanced glycation end products in uremia: simple coexistence, potentiation or causal relationship? (11168979)
2001
36
Human thiopurine S-methyltransferase activity in uremia and after renal transplantation. (11417444)
2001
37
Optic neuropathy in uremia: an interdisciplinary emergency. (11228200)
2001
38
The heart in uremia: role of hypertension, hypotension, and sleep apnea. (11576920)
2001
39
Derangement of acid-base balance in uremia and under hemodialysis. (11798141)
2001
40
A novel mechanism for skeletal resistance in uremia. (10916099)
2000
41
Cell biology of parathyroid hyperplasia in uremia. (10372837)
1999
42
Pathophysiology of the oxidative stress and its implication in uremia and dialysis. (10629773)
1999
43
Effect of uremia and hemodialysis on soluble L-selectin and leukocyte surface CD11b and L-selectin. (9428454)
1998
44
Advanced oxidation protein products: oxidative stress markers and mediators of inflammation in uremia. (9889997)
1998
45
Uremia and HbA1c measured by high-performance liquid chromatography. (9540038)
1998
46
Implication of altered redox regulation by antioxidant enzymes in the increased plasma pentosidine, an advanced glycation end product, in uremia. (9588192)
1998
47
Reduced hepatic growth hormone (GH) receptor gene expression and increased plasma GH binding protein in experimental uremia. (8007578)
1994
48
Effect of serum parathyroid hormone and bone marrow fibrosis on the response to erythropoietin in uremia. (8417383)
1993
49
Effects of uremia and dialysis on brain electrophysiology after recombinant erythropoietin treatment. (1457906)
1992
50
Buccal mucosa bleeding times of healthy dogs and of dogs in various pathologic states, including thrombocytopenia, uremia, and von Willebrand's disease. (3499100)
1987

Genetic Variations for Uremia

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Expression for genes affiliated with Uremia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Uremia

Search GEO for disease gene expression data for Uremia.

Pathways for genes affiliated with Uremia

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37NCBI BioSystems Database
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Pathways related to Uremia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.5PTH, TNFRSF11B

Compounds for genes affiliated with Uremia

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Uremia according to GeneCards/GeneDecks:

(show top 50)    (show all 108)
idCompoundScoreTop Affiliating Genes
1tyrosine4411.2TPMT, ALAD, PTH, RETN, PF4, AHSG
2calcium44 49 11 2414.1AGER, ITGAM, AOC3, RHD, TNFRSF11B, IGFBP2
3creatinine4411.1PTH, ALAD, TPMT, RETN, PF4, EPO
4lipid4411.1TNFRSF11B, GLO1, AMBP, RHD, ITGAM, AOC3
5glucose4411.1AMBP, CASR, APOC3, ITGAM, RHD, IGFBP2
6vitamin d4411.1MEN1, NR1I3, TNFRSF11B, CASR, EPO, AHSG
7nitric oxide44 11 2413.1RETN, PTH, AGER, GLO1, CASR, TNFRSF11B
8oxygen44 2412.1RHD, NR1I3, AGER, IGFBP2, EPO, PF4
9fibrinogen4411.0AMBP, AHSG, TNFRSF11B, RETN, APOC3, IGFBP2
10vegf4411.0ITGAM, MEN1, TNFRSF11B, PTH, AGER, RETN
11cholesterol44 28 11 2414.0IGFBP2, PF4, RETN, APOC3, AGER, NR1I3
12calcitriol44 59 11 2414.0CASR, EPO, TNFRSF11B, ITGAM, NR1I3, IGFBP2
13atp44 2812.0GLO1, RHD, PF4, PTH, ALAD, ITGAM
14steroid4411.0TPMT, RETN, PF4, GLO1, NR1I3, IGFBP2
15lysine4411.0RHD, NR1I3, OXA1L, PF4, AOC3, TNFRSF11B
16testosterone44 59 11 2414.0APOC3, PTH, RETN, ALAD, TNFRSF11B, EPO
17serine4411.0AMBP, CASR, RHD, AGER, NR1I3, ITGAM
18cyclosporin a44 28 5913.0TPMT, EPO, NR1I3, ITGAM, TNFRSF11B, CASR
19cysteine4411.0CASR, AMBP, RETN, TNFRSF11B, ITGAM, OXA1L
20p0024411.0TNFRSF11B, RETN, PF4, IGFBP2, ITGAM, APOC3
21thymidine44 2412.0IGFBP2, PTH, PF4, NR1I3, EPO, MEN1
22malondialdehyde4411.0PF4, ALAD, AOC3, AGER, EPO
23sodium44 2412.0NR1I3, AMBP, CASR, PTH, RETN, TNFRSF11B
24ethanol44 49 11 2413.9RHD, ALAD, ITGAM, NR1I3, AHSG, PF4
25estradiol44 11 2412.9ALAD, NR1I3
26superoxide44 2411.9PF4, ALAD, GLO1, ITGAM
27estrogen4410.9APOC3, AHSG
28urea44 11 2412.9RETN, AMBP, TNFRSF11B, GLO1, EPO
29phosphorus4410.9PTH, CASR, TNFRSF11B, NR1I3
30thyroxine44 2411.9TNFRSF11B, PTH, OXA1L, IGFBP2, RETN
31hydroxyproline44 11 2412.9AOC3, TNFRSF11B, PTH, AHSG
32hydroxyapatite4410.9TNFRSF11B, CASR, AMBP, AHSG
33lactate4410.9GLO1, ITGAM, PF4, EPO, AMBP, ALAD
34forskolin44 49 1112.8IGFBP2, RETN, PTH
35dhea4410.8NR1I3, RETN, IGFBP2, TNFRSF11B
36polyacrylamide4410.8RHD, GLO1, AHSG, AMBP, APOC3
37pamidronate44 49 1112.8PTH, CASR, TNFRSF11B
38aprotinin44 1111.8AMBP, EPO, PF4, PTH
39xbai4410.8AHSG, CASR, APOC3
40alanine4410.8CASR, NR1I3, TPMT, AMBP, PF4, RETN
41heparin44 28 11 2413.8ITGAM, PF4, AGER, APOC3, TNFRSF11B
42uric acid44 2411.7ALAD
43aminoguanidine44 28 1112.7EPO, AOC3, OXA1L
44adenylate4410.7RHD, PF4, GLO1, PTH, CASR, ITGAM
45latex4410.7RHD, ITGAM, AMBP, PF4
46sodium dodecylsulfate4410.6AMBP, OXA1L, IGFBP2, RHD
471,25 dihydroxy vitamin d34410.6NR1I3, PTH, CASR, TNFRSF11B
48homocysteine44 2411.5RHD, APOC3, TNFRSF11B, RETN
49l-tryptophan44 28 11 2413.4CASR, NR1I3, OXA1L
50cuprophan4410.2PF4, EPO, ITGAM

GO Terms for genes affiliated with Uremia

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16Gene Ontology
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Cellular components related to Uremia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.6AMBP, TNFRSF11B, APOC3, AGER, IGFBP2, EPO
2extracellular spaceGO:00561510.3AMBP, TNFRSF11B, APOC3, IGFBP2, EPO, AHSG

Biological processes related to Uremia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to nutrientGO:00758410.5IGFBP2, APOC3, TNFRSF11B

Molecular functions related to Uremia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00517910.5PTH, RETN, EPO

Products for genes affiliated with Uremia

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Uremia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet