Uremia malady

Wikipedia: Uremia or uraemia (see spelling differences) is a term used to loosely describe the illness accompanying...⁴⁴ more...

MalaCards: Uremia, also known as uremia of renal origin, is related to hepatitis and hypertension. An important gene associated with Uremia is EPO (erythropoietin), and among its related pathways are ACE Inhibitor Pathway, Pharmacodynamics and Statin Pathway, Pharmacodynamics. The drugs charcoal and charcoal,activated pwdr [va product] and the compounds lysine and phosphorus have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, brain and heart, and related mouse phenotypes are hematopoietic system and craniofacial.

Aliases & Descriptions:

uremia 6 8 32 43 uremia of renal origin 6

uremia (disorder) 6 uremia nos 6

Diseases related to uremia by text searches and GeneDecks gene sharing:

(show top 50)    (show all 982)

id	Related Disease	Score	Top Affiliating Genes
1	hepatitis	29.9	IL2RB, FAS, F2, ALB, CR1, THPO
2	hypertension	29.8	REN, NOS2, NOS3, ACE, AGT, AGTR1
3	sleep apnea	28.7	RETN, LEP, GHR, LSL, NPY, ADIPOQ
4	osteomalacia	28.5	VDR, MEN1, ENPP1, ANKRD36C, CASR, CALCA
5	primary hyperparathyroidism	28.3	RET, VDR, CHGA, MEN1, IGFBP1, CASR
6	hepatitis b	27.1	IL10, IFNG, F2, ALB, CR1, NOS3
7	liver cirrhosis	26.2	REN, RETN, SERPINC1, VIP, LPA, LDLR
8	arthritis	25.3	SELL, VIP, IL1B, IL6, TNF, TIMP1
9	hyperparathyroidism	24.6	RET, VWF, SERPINE1, VIP, VDR, LEP
10	hyperhomocysteinemia	23.7	VWF, SERPINC1, SERPINE1, LPA, VCAM1, BHMT
11	aldosteronism	23.0	REN, RETN, SERPINE1, VIP, CHGA, B2M
12	hemolytic-uremic syndrome	22.6	VWF, SERPINC1, SERPINE1, CFB, INS, IL10
13	hypertriglyceridemia	22.2	SERPINE1, LPA, LPL, VCAM1, LIPC, LEP
14	arteriosclerosis	22.0	SERPINE1, LPA, LPL, VCAM1, LDLR, CD2
15	apnea	20.8	REN, RET, RETN, VWF, SERPINE1, LPL
16	insulin resistance	19.6	REN, RETN, VWF, SELL, SERPINE1, LPA
17	essential hypertension	19.3	REN, RETN, VWF, SELL, SERPINC1, SERPINE1
18	homocysteine	18.7	REN, RETN, VWF, SERPINC1, SERPINE1, LPA
19	anemia	18.6	REN, VWF, SELL, SERPINC1, LPL, VDR
20	thrombosis	17.9	REN, RETN, VWF, SELL, SERPINC1, SERPINA5
21	atherosclerosis	16.8	REN, RETN, VWF, SELL, SERPINC1, SERPINE1
22	adenoma	16.2	REN, RET, RETN, VIP, VDR, BHMT
23	obesity	15.3	REN, RETN, VWF, SELL, SERPINC1, SERPINE1
24	peritonitis	15.1	REN, RET, VWF, SELL, SERPINC1, SERPINE1
25	rheumatoid arthritis	14.5	RETN, VWF, SELL, SERPINC1, SERPINE1, VIP
26	diabetes mellitus	14.5	REN, RET, RETN, VWF, SELL, SERPINC1
27	parathyroid carcinoma	14.1	MEN1, CASR, PTH, CXADR
28	growth disorders	14.0	IGFBP1, IGFBP2, IGF1, GH1, GHR
29	hyperphosphatemia	14.0	VDR, MGP, ALB, CASR, TNFRSF11B, PTH
30	glycogen storage disease type ia	14.0	VWF, LPL, CRP, SOD1, PON1
31	hypocalciuric hypercalcemia	14.0	CASR, CALCA, PTH, NR1I3, CXADR
32	mccune albright syndrome	14.0	CFD, MEN1, IGF1, GH1, GHR, SLC34A1
33	marasmus	14.0	ALB, GH1, LSL, TF
34	acid-labile subunit	14.0	APOA1, IGFBP1, IGFBP2, IGF1, GH1, GHR
35	hypocalcemia	14.0	VDR, ALB, CASR, CALCA, PTH, CYP27B1
36	variegate porphyria	13.9	LIPC, ALAD, ALB, HMOX1, NR1I3, TF
37	hemolytic anemia	13.9	VWF, LCAT, APOH, CR1, RHD, TF
38	osteoporosis, postmenopausal	13.9	VDR, IGF1, CALCA, GHR, TNFRSF11B, PTH
39	familial isolated hyperparathyroidism	13.9	RET, MEN1, CASR, PTH
40	hemorrhagic shock and encephalopathy syndrome	13.9	ITGAM, HMOX1, NOS2, NOS3, ABP1, OXA1L
41	hypophosphatemia	13.9	VDR, B2M, ENPP1, AMBP, ALB, CASR
42	fibrosis	13.9	REN, RETN, VWF, SELL, SERPINC1, SERPINE1
43	growth hormone secreting pituitary adenoma	13.9	MEN1, IGF1, GH1, GHR, GHRL
44	parathyroid disorders	13.9	RET, MEN1, CASR, PTH
45	essential thrombocythemia	13.9	VWF, PPBP, PF4, THBD, THPO, EPO
46	hyperalphalipoproteinemia	13.9	LPL, LIPC, LDLR, LCAT, APOA1, APOB
47	delayed puberty	13.9	LEP, IGF1, GHR, LSL, NPY
48	hypothyroidism	13.9	RETN, LPA, LEP, APOB, GHRL, LSL
49	growth retardation with deafness and mental retardation due to igf1 deficiency	13.9	INSR, IGFBP1, IGFBP2, IGF1, GH1, GHR
50	leptin deficiency	13.9	LEP, CCK, GH1, LSL, NPY

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 charcoal, charcoal,activated, charcoal,activated pwdr [va product]

MalaCards organs/tissues related to uremia:

²²

MGI Mouse Phenotypes related to uremia:

²⁵ (show all 27)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system phenotype	MP:0005397	10.3	CCND1, ICMT, CASR, EPO, RUNX2, CXADR
2	craniofacial phenotype	MP:0005382	9.9	RUNX2, CSF1, EDN1, PTH1R, PTH, MEN1
3	respiratory system phenotype	MP:0005388	9.8	RUNX2, PTH1R, TRIM63, CALCA, APOE, MGP
4	endocrine/exocrine gland phenotype	MP:0005379	9.5	RET, SELL, SERPINA5, RUNX2, TKT, PTH
5	embryogenesis phenotype	MP:0005380	8.9	CXADR, ACACA, EGFR, PTK2, PTH1R, F2
6	limbs/digits/tail phenotype	MP:0005371	8.7	TNFRSF11B, PTH, PTK2, EGFR, CSF1, RUNX2
7	no phenotypic analysis	MP:0003012	8.5	RUNX2, NPHP1, AGER, EGFR, PTK2, TP53
8	hearing/vestibular/ear phenotype	MP:0005377	8.3	TNFRSF11B, PLAT, EDN1, EGFR, SOD1, CALCA
9	renal/urinary system phenotype	MP:0005367	8.3	LCAT, CHGA, BHMT, RET, REN, CASR
10	pigmentation phenotype	MP:0001186	7.9	CASP3, CASR, TP53, EGFR, CP, FAS
11	nervous system phenotype	MP:0003631	7.8	RUNX2, CP, NPY, CSF1, PROC, PROS1
12	liver/biliary system phenotype	MP:0005370	7.4	EPO, SOD1, PROS1, AGT, ACACA, APOB
13	skeleton phenotype	MP:0005390	7.3	PLAT, CCND1, ENPP1, FAS, IL6, MGP
14	integument phenotype	MP:0010771	7.2	F2, IFNG, CCND1, FAS, IL2RB, ITGB1
15	reproductive system phenotype	MP:0005389	7.1	ADIPOQ, ADCY10, SLC34A1, NPHP1, CSF1, TIMP1
16	digestive/alimentary phenotype	MP:0005381	7.0	CASP3, RET, VWF, VDR, LEP, F2
17	adipose tissue phenotype	MP:0005375	6.7	ADIPOQ, GHRL, GHR, GH1, IGF1, ENPP1
18	behavior/neurological phenotype	MP:0005386	6.2	REN, AGT, AGER, ACE, NOS3, NOS2
19	immune system phenotype	MP:0005387	6.1	CYP27B1, AOC3, APOA1, IL6, MEN1, ITGAM
20	muscle phenotype	MP:0005369	5.5	ADIPOQ, RUNX2, SLC34A1, NOS2, PLAT, PLA2G6
21	tumorigenesis	MP:0002006	5.1	IFNG, TP53, TNF, PTK2, SPP1, PLA2G2A
22	vision/eye phenotype	MP:0005391	5.0	EGFR, NOS3, NOS2, PLAT, TNF, TTR
23	growth/size phenotype	MP:0005378	4.6	CCND1, B2M, UBC, UCP2, LDLR, CHGA
24	cellular phenotype	MP:0005384	4.2	TNF, AOC3, FAS, APOE, APOC3, APOA1
25	homeostasis/metabolism phenotype	MP:0005376	3.4	EPO, CASR, APOH, APOE, APOC3, APOB
26	mortality/aging	MP:0010768	2.7	PLAT, GHR, CASR, CAST, F2, ICMT
27	cardiovascular system phenotype	MP:0005385	1.1	PROC, PROS1, TGFA, THBD, TIMP1, TKT

Articles related to uremia:

(show top 50)    (show all 147)

id	Title	Authors	Year	Affiliating Genes
1	Uremia induces proximal tubular cytoresistance and heme oxygenase-1 expression in the absence of acute kidney injury. (19036845)	Zager R.A.	2009	HMOX1
2	C-reactive protein and uremia. (19708997)	Wanner C.... Krane V.	2009	CRP
3	Effects of uremia and inflammation on growth hormone resistance in patients with chronic kidney diseases. (18633341)	Garibotto G.... Minuto F.	2008	GH1
4	Inflammation and insulin resistance in uremia. (18089448)	Zanetti M.... Guarnieri G.	2008	INS
5	Advances in carnitine in chronic uremia. (17198928)	Guarnieri G.... Barazzoni R.	2007	INS, EPO
6	Inflammation and adipose tissue in uremia. (16825020)	Barazzoni R.... Guarnieri G.	2006	TNF, LEP, ADIPOQ
7	Increased parathyroid hormone gene expression in secondary hyperparathyroidism of experimental uremia is reversed by calcimimetics: correlation with posttranslational modification of the trans acting factor AUF1. (16291838)	Levi R.... Silver J.	2006	CASR, NR1I3
8	Thrombocytopathy and blood complications in uremia (16773479)	HAPrl W.H.	2006	EPO
9	Fetuin-A and extraosseous calcification in uremia. (15931001)	Ketteler M.	2005	AHSG
10	In uremia, plasma levels of anti-protein C and anti-protein S antibodies are associated with thrombosis. (16105054)	Molino D.... De Santo N.G.	2005	PLAT, SERPINE1, F2
11	Chronic systemic inflammation in uremia: potential therapeutic approaches. (15490407)	Guarnieri G.... Barazzoni R.	2004	IL6
12	Plasma cell membrane glycoprotein 1 (PC-1): a marker of insulin resistance in obesity, uremia and diabetes mellitus. (15209435)	Stefanovic V.... Antic S.	2004	ENPP1, TIMP1, INS
13	Increased platelet phosphatidylserine exposure and ca spase activation in chronic uremia. (15304031)	Bonomini M.... Sirolli V.	2004	CASP3
14	Eating behavior disorders in uremia: a question of balance in appetite regulation. (14717811)	Aguilera A.... Selgas R.	2004	LPL, IGF1, NPY
15	In vitro evidence for immune activating effect of spe cific AGE structures retained in uremia. (15496158)	Glorieux G.... Vanholder R.	2004	CD14
16	Uremia-associated immune defect: the IL-10-CRP axis. (12694315)	Girndt M.... KAPhler H.	2003	IL10
17	Atherosclerosis and uremia: signifance of non-traditional risk factors (12778774)	HAPrl W.H.	2003	CRP
18	Paraoxonase activity and paraoxonase 1 gene polymorphism in patients with uremia. (12790379)	Biasioli S.... Fasolin A.	2003	PON1
19	Calpain is activated in experimental uremia: is calpain a mediator of uremia-induced myocardial injury? (12631067)	Harwood S.M.... Yaqoob M.M.	2003	CASP3, CAST
20	Some parameters of platelet activation in patients with uremia before and after hemodialysis (HD) (12731371)	Dymicka-Piekarska V.... Piszka J.	2002	PPBP, PF4
21	Phospholipase A2 activity in platelets of patients with uremia. (12487789)	Vecino A.M.... Cesar J.M.	2002	PLA2G2A
22	The elephant in uremia: oxidant stress as a unifying concept of cardiovascular disease in uremia. (12371953)	Himmelfarb J.... Hakim R.M.	2002	ALB, B2M
23	Human thiopurine S-methyltransferase activity in uremia and after renal transplantation. (11417444)	Weyer N.... Iven H.	2001	TPMT
24	Calcitriol increases burst forming unit-erythroid (B FU-E) in vitro proliferation in chronic uremia. Synergic effect with DNA recomb inant erythropoietin (rHu-Epo) (11346713)	Aucella F.... Stallone C.	2001	EPO
25	Metabolic consequences of hyperhomocysteinemia in uremia. (11576929)	Perna A.F.... De Santo N.G.	2001	ALB, ICMT
26	Plasma and platelet von Willebrand factor abnormalities in patients with uremia: lack of correlation with uremic bleeding. (11292197)	Casonato A.... Girolami A.	2001	VWF, F8
27	The heart in uremia: role of hypertension, hypotension, and sleep apnea. (11576920)	De Santo N.G.... Rossi F.	2001	CRP
28	Albumin is the major plasma protein target of oxidant stress in uremia. (11422772)	Himmelfarb J.... McMonagle E.	2001	ALB
29	The microinflammatory state in uremia: causes and potential consequences. (11423586)	Kaysen G.A.	2001	TF, ALB, TTR
30	Immunochemical detection of imidazolone in uremia and rheumatoid arthritis. (10958861)	Franke S.... Stein G.	2000	ALB
31	Modulation of parathyroid cell function by calcium ion in health and uremia. (10372834)	Akizawa T.... Fukagawa M.	1999	CASR
32	Sexual dysfunction in uremia. (10361878)	Palmer B.F.	1999	EPO
33	Effect of uremia and hemodialysis on soluble L-selectin and leukocyte surface CD11b and L-selectin. (9428454)	Dou L.... Berland Y.	1998	SELL, ITGAM
34	Recombinant erythropoietin and cardiovascular risk in uremia (9796377)	Buemi M.... Frisina N.	1998	EPO
35	The peripheral blood levels of TNF alpha and PLA2 activities in dialysis and non-dialysis patients with uremia (9868037)	Duan S.... Liu F.	1997	PLA2G6
36	Reduction of plasma apolipoprotein-B by effective removal of circulating glycation derivatives in uremia. (9407512)	Fishbane S.... Vlassara H.	1997	APOB
37	Mechanisms of malnutrition in uremia. (9350678)	Guarnieri G.... Biolo G.	1997	INS
38	Severity of AIDS and the response to EPO in uremia. (9214398)	Ifudu O.... Friedman E.A.	1997	ALB, EPO
39	Uremia enhances the blood pressure response to erythropoietin. (9140703)	Lacasse-M S.... Lebel M.	1997	EPO
40	Activities of nitric oxide in normal physiology and uremia. (8734457)	Blantz R.C.... Thomson S.	1996	NOS2
41	Dysfunction of polymorphonuclear leukocytes in uremia. (8734462)	Haag-Weber M.... HAPrl W.H.	1996	CFD
42	Advanced oxidation protein products as a novel marker of oxidative stress in uremia. (8731095)	Witko-Sarsat V.... Descamps-Latscha B.	1996	ALB, OXA1L
43	Secondary hyperparathyroidism and tertiary hyperparathyroidism chronic renal failure, uremia (7752492)	Morio K.... Koide K.	1995	CALCA
44	Measurement of serum levels of macrophage colony-stimulating factor (M-CSF) in patients with uremia. (8425560)	Kawano Y.... Kuroda Y.	1993	EPO, CSF1
45	Serum lipids predict cardiac death in diabetic patients on maintenance hemodialysis. Results of a prospective study. The German Study Group Diabetes and Uremia. (8341379)	TschAPpe W.... Ritz E.	1993	APOB
46	Effect of desmopressin (DDAVP) on protein C and protein C inhibitors in uremia. (8321356)	Akpolat T.... Kirazli S.	1993	SERPINA5
47	The circadian rhythm of erythropoietin in subjects with pre-terminal uremia. (1563123)	Buemi M.... Frisina N.	1992	EPO
48	Platelet aggregation during the recombinant human erythropoietin (rHuEPO) treatment of patients with uremia (1488323)	Mazerska M.... Buczko W.	1992	EPO
49	The vitamin D/parathyroid hormone axis in the pathogenesis of hypertension and insulin resistance in uremia. (1465050)	Mak R.H.... Wong J.H.	1992	INS
50	Immune deficiency in uremia: interleukin-2 production and responsiveness and interleukin-2 receptor expression and release. (1896091)	Donati D.... Raska K.	1991	IL2RB

Genes related to uremia according to GeneCards:

(show top 50)    (show all 127)

id	Symbol	Description	Score	GeneCards Section Context
1	EPO	erythropoietin	11.0	Publications
2	RHD	Rh blood group, D antigen	11.0	Publications
3	AHSG	alpha-2-HS-glycoprotein	11.0	Publications
4	PTH	parathyroid hormone	11.0	Publications
5	ALAD	aminolevulinate dehydratase	11.0
6	GLO1	glyoxalase I	11.0
7	MEN1	multiple endocrine neoplasia I	11.0	Publications
8	PF4	platelet factor 4	11.0	Publications
9	AOC3	amine oxidase, copper containing 3 (vascular adhesion protein 1)	11.0
10	TPMT	thiopurine S-methyltransferase	11.0	Publications
11	IGFBP2	insulin-like growth factor binding protein 2, 36kDa	11.0	Publications
12	NR1I3	nuclear receptor subfamily 1, group I, member 3	11.0	Publications
13	PLA2G6	phospholipase A2, group VI (cytosolic, calcium-independent)	11.0	Publications
14	ITGAM	integrin, alpha M (complement component 3 receptor 3 subunit)	11.0	Publications
15	LCAT	lecithin-cholesterol acyltransferase	11.0
16	CASR	calcium-sensing receptor	11.0	Publications
17	OXA1L	oxidase (cytochrome c) assembly 1-like	11.0	Publications
18	TNFRSF11B	tumor necrosis factor receptor superfamily, member 11b	11.0	Publications
19	RETN	resistin	11.0	Publications
20	ENPP1	ectonucleotide pyrophosphatase/phosphodiesterase 1	11.0	Publications
21	IGFBP1	insulin-like growth factor binding protein 1	11.0	Publications
22	AMBP	alpha-1-microglobulin/bikunin precursor	11.0
23	AGER	advanced glycosylation end product-specific receptor	11.0
24	APOC3	apolipoprotein C-III	11.0	Publications
25	GHR	growth hormone receptor	11.0	Publications
26	PON1	paraoxonase 1	11.0	Publications
27	SPP1	secreted phosphoprotein 1	11.0	Publications
28	CXADR	coxsackie virus and adenovirus receptor	11.0
29	LIPC	lipase, hepatic	11.0	Publications
30	LPL	lipoprotein lipase	11.0	Publications
31	B2M	beta-2-microglobulin	11.0	Publications
32	LSL	Leptin, serum levels of	11.0
33	VDR	vitamin D (1,25- dihydroxyvitamin D3) receptor	11.0	Publications
34	ADIPOQ	adiponectin, C1Q and collagen domain containing	11.0	Publications
35	GH1	growth hormone 1	11.0	Publications
36	VCAM1	vascular cell adhesion molecule 1	11.0
37	IGF1	insulin-like growth factor 1 (somatomedin C)	11.0	Publications
38	NOS2	nitric oxide synthase 2, inducible	11.0	Publications
39	VWF	von Willebrand factor	11.0	Publications
40	ALB	albumin	11.0	Publications
41	ADCY10	adenylate cyclase 10 (soluble)	11.0
42	TF	transferrin	11.0	Publications
43	LEP	leptin	11.0	Publications
44	LPA	lipoprotein, Lp(a)	11.0
45	CR1	complement component (3b/4b) receptor 1 (Knops blood group)	11.0	Publications
46	CRP	C-reactive protein, pentraxin-related	11.0	Publications
47	INSR	insulin receptor	11.0	Publications
48	LDLR	low density lipoprotein receptor	11.0
49	SOD1	superoxide dismutase 1, soluble	11.0	Publications
50	NOS3	nitric oxide synthase 3 (endothelial cell)	11.0

Pathways related to uremia according to GeneDecks:

(show top 50)    (show all 83)

id	Pathway	Score	Top Affiliating Genes
1	ACE Inhibitor Pathway, Pharmacodynamics34	10.5	NR3C2, AGTR1
2	Statin Pathway, Pharmacodynamics34	10.3	APOE, APOC3, APOB, APOA1, LCAT, LDLR
3	Glucose / Energy Metabolism3	10.3	AHSG, TKT, ADIPOQ, SREBF1, IGFBP2, ENPP1
4	Selected targets of HNF110	10.0	F8, APOA1, INS, CRP, UCP2, LPA
5	Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics34	9.8	AGTR1, AGT, NOS3, NR3C2, REN, ACE
6	Metabolism of lipids and lipoproteins38	9.7	ALB, CYP27B1, FASN, PLA2G6, PLA2G2A, ACACA
7	Paxillin Interactions36	9.7	IGF1, PPBP, TGFA, THPO, ITGAM, ITGB1
8	ILK Signaling36	9.7	ITGAM, TGFA, TIMP1, EGFR, PTK2, GH1
9	Amoebiasis20	9.5	ITGAM, CD14, NOS2, PTK2, IL6, IL1B
10	Glioma Invasiveness36	9.5	ITGB1, TGFA, TIMP1, PPBP, THPO, GH1
11	Selected targets of GCR-alpha10	9.5	LEP, INS, IL1B, IL6, GHR, NR1I3
12	Blood Coagulation Signaling Pathways37	9.5	SERPINC1, THBD, PROC, PROS1, PLAT, F2
13	Complement and coagulation cascades20	9.4	CR1, THBD, VWF, SERPINC1, SERPINE1, SERPINA5
14	PTEN Pathway36	9.4	TP53, ITGAM, PPBP, EGFR, THPO, PTK2
15	Rho Family GTPases36	9.2	CSF1, TGFA, THPO, PF4, PPBP, SPP1
16	Akt Signaling36	9.1	CCND1, TNF, PTK2, PF4, THPO, IL6
17	Hematopoietic cell lineage20	9.1	ITGAM, CSF1, EPO, THPO, CR1, TNF
18	PPAR Pathway36	8.9	ITGAM, THPO, EGFR, PPBP, TNF, GH1
19	Pertussis20	8.8	CASP3, IL6, IL1B, ITGB1, IL10, CD14
20	DHA Signaling36	8.7	IL6, IGF1, TIMP1, THPO, EGFR, PLA2G2A
21	IL-10 Pathway36	8.6	IL1B, CD14, IL10, TNF, HMOX1, IL6
22	p53 Mediated Apoptosis36	8.6	GH1, CASP3, IL6, TP53, PPBP, EGFR
23	Renin-Angiotensin Pathway36	8.5	VCAM1, REN, IL6, ACE, AGT, AGTR1
24	Leishmaniasis20	8.5	IL1B, IL10, ITGB1, ITGAM, TNF, IFNG
25	MIF Mediated Glucocorticoid Regulation36	8.5	TNF, CD2, CD14, IL10, CSF1, IL1B
26	Apoptotic Pathways in Synovial Fibroblasts36	8.4	GH1, TGFA, THPO, IGF1, EGFR, PPBP
27	Molecular Mechanisms of Cancer36	8.4	TP53, CD2, ITGAM, ITGB1, GH1, CCND1
28	ERK Signaling36	8.4	TGFA, ITGAM, ITGB1, INSR, IL10, IL1B
29	Immune response IL-1 signaling pathway10	8.4	EDN1, SERPINE1, IL1B, IL6, CP, TNF
30	Endothelin-1 Signaling Pathway36	8.4	EGFR, CSF1, PLA2G2A, CASP3, PF4, CD2
31	TGF-Beta Pathway36	8.4	IL1B, CD2, IL10, TIMP1, EGFR, PPBP
32	Immune response_IL-1 signaling pathway41	8.3	CP, TNF, EDN1, HMOX1, IL6, IL1B
33	MIF Regulation of Innate Immune Cells36	8.3	TP53, PF4, CSF1, PLA2G2A, TNF, IL6
34	NF-KappaB (p50-p65) Pathway36	8.2	THPO, UBC, IL1B, IL6, IGF1, EGFR
35	Cellular Apoptosis Pathway36	8.1	IGF1, THPO, TP53, TGFA, IL6, EGFR
36	Tuberculosis20	8.0	VDR, IFNG, IL6, IL1B, IL10, ITGAM
37	Transcription_Role of VDR in regulation of genes involved in osteoporosis41	8.0	RUNX2, IL6, APOE, IGF1, IFNG, CALCA
38	Transcription Role of VDR in regulation of genes involved in osteoporosis10	8.0	VDR, IL1B, IL6, APOE, IGF1, IFNG
39	Antioxidant Action of Vitamin-C36	8.0	IL2RB, CD2, IL1B, IL10, CSF1, TGFA
40	African trypanosomiasis20	7.9	IFNG, FAS, IL10, APOA1, IL6, IL1B
41	Tec Kinases Signaling36	7.9	PTK2, TIMP1, EGFR, PPBP, ITGB1, INSR
42	Immune response MIF in innate immunity response10	7.9	NOS2, TNF, TP53, IFNG, IL6, IL1B
43	Immune response_MIF in innate immunity response41	7.8	IL6, IFNG, TP53, TNF, CD14, NOS2
44	Malaria20	7.8	IFNG, IL10, VCAM1, IL1B, IL6, TNF
45	PAK Pathway36	7.8	IL6, IGF1, TGFA, THPO, TIMP1, EGFR
46	MAPK Signaling36	7.6	TNF, ITGAM, ITGB1, INSR, IL1B, IL6
47	Cytokine-cytokine receptor interaction20	7.4	FAS, IL6, IL2RB, GHR, EPO, IL1B
48	p38 Signaling36	7.4	IL1B, PF4, EGFR, GH1, TIMP1, THPO
49	Chagas disease (American trypanosomiasis)20	7.2	NOS2, ACE, SERPINE1, IL10, IL1B, IL6
50	JAK-STAT Pathway36	7.1	TIMP1, TGFA, AGTR1, THPO, AGT, EPO

Compounds related to uremia according to GeneDecks:

(show top 50)    (show all 545)

id	Compound	Score	Top Affiliating Genes
1	lysine32	10.7	LDLR, LCAT, MGP, AOC3, ENPP1, ALAD
2	phosphorus32	10.6	VDR, B2M, CASR, CALCA, PTH, PTH1R
3	phosphatidylserine32 9 9	12.3	VWF, LPL, CD14, F2, PLA2G6, THBD
4	palmitate32	10.1	LDLR, UCP2, APOA1, FASN, GHR, PLA2G6
5	lovastatin32 42 9 9	13.1	LPA, LPL, LIPC, LDLR, INSR, APOB
6	pioglitazone32 9 9	12.0	RETN, LPL, VCAM1, LIPC, LEP, CFD
7	p00232	9.9	RETN, LPA, LIPC, LEP, CHGA, CD14
8	l-nmma32	9.9	VIP, VCAM1, INSR, CCK, GH1, GHRL
9	hyaluronic acid32 18	10.8	B2M, F2, PPBP, PLA2G2A, TTR, THBD
10	gemfibrozil32 9 9	11.8	LPA, LPL, LIPC, LDLR, INS, APOA1
11	latex32	9.8	VWF, CD2, CD14, ITGAM, APOH, F8
12	gnrh32	9.8	SELL, SERPINE1, LEP, INS, IGFBP1, IGFBP2
13	polysaccharide32	9.7	SELL, SERPINC1, LPL, VCAM1, LIPC, B2M
14	aprotinin32 9 9	11.7	VWF, SERPINC1, VIP, IGF1, AMBP, F2
15	bezafibrate32 9 9	11.6	SERPINE1, LPA, LPL, LIPC, LDLR, UCP2
16	vitamin a32 9 18 9	12.6	RET, RETN, VWF, LPL, VDR, LIPC
17	octreotide32 42 9 9	12.5	VIP, CHGA, INS, INSR, CCK, IGFBP1
18	polyethylene glycol32	9.4	SERPINC1, VIP, INSR, APOA1, APOE, IGFBP1
19	intralipid32	9.4	LPL, LIPC, LEP, LCAT, APOA1, APOB
20	aspartate32	9.4	RET, RETN, VIP, VDR, LDLR, B2M
21	estradiol32 9 18 9	12.3	REN, SERPINE1, ITGB1, FASN, CCND1, IGFBP1
22	atp32	9.3	RET, LIPC, CHGA, UCP2, CD14, ITGAM
23	oxygen32 18	10.2	LIPC, ITGAM, ITGB1, IL2RB, APOH, FAS
24	glutamate32	9.1	VIP, VDR, LEP, LDLR, LCAT, INS
25	progestin32	9.0	SERPINC1, INSR, APOA1, CCND1, IGFBP1, IGFBP2
26	hydrochlorothiazide32 34 9 18 9	13.0	REN, SERPINE1, VDR, APOA1, ALB, CASR
27	fenofibrate32 9 9	10.9	RETN, SERPINE1, LPA, LPL, VCAM1, LIPC
28	ribonucleic acid32	8.8	RET, CHGA, UCP2, IL1B, IL2RB, FAS
29	phosphatidylcholine32	8.7	VIP, LPA, LPL, VCAM1, LIPC, LDLR
30	aminoguanidine32 9 9	10.7	LEP, IL1B, APOB, AOC3, IFNG, ALB
31	arachidonic acid32 9 18 9	11.4	VWF, LPL, LIPC, UCP2, ITGAM, ITGB1
32	rapamycin32 42	9.4	SELL, LDLR, INS, IL2RB, FBXO32, FASN
33	acetylcholine32 9 18 9	11.3	VWF, VIP, LPL, LEP, CHGA, LDLR
34	epinephrine32 9 18 9	11.3	REN, SELL, VIP, LEP, CHGA, ITGAM
35	heparin32 9 18 9	11.3	VWF, SERPINA5, SERPINE1, LPA, LPL, LIPC
36	fibrinogen32	8.3	RETN, SERPINC1, SERPINA5, SERPINE1, LPA, VCAM1
37	losartan32 34 9 9	11.2	REN, VWF, SERPINE1, VCAM1, LEP, APOE
38	prostaglandin32	8.1	REN, VIP, UCP2, IL1B, IL6, AMBP
39	troglitazone32 42 9 9	10.9	SERPINE1, LPL, VDR, VCAM1, LEP, LDLR
40	cysteine32	7.9	LPA, VDR, LDLR, LCAT, CD14, ITGAM
41	testosterone32 9 18 9	10.8	RET, SERPINC1, VIP, LPL, VDR, VCAM1
42	alanine32	7.4	RET, RETN, VWF, SELL, SERPINC1, VIP
43	cyclosporin a32 42	8.4	VWF, VIP, LPL, VDR, LIPC, LEP
44	arginine32	7.3	REN, RET, VWF, SERPINC1, VIP, LPA
45	rantes32	7.2	SELL, VIP, VCAM1, CD14, ITGAM, IL10
46	aspirin32 34 18	9.0	VWF, SELL, SERPINC1, SERPINE1, LPA, VDR
47	norepinephrine32 9 18 9	9.9	REN, RETN, VWF, SELL, VIP, LPL
48	cholesterol32 9 18 9	9.3	REN, RETN, VWF, SERPINE1, LPA, LPL
49	indomethacin32 9 9	7.5	REN, SELL, VIP, LPL, LEP, LDLR
50	dexamethasone32 42 34 9 9	7.9	REN, RETN, VWF, SELL, SERPINC1, SERPINE1

Cellular components related to uremia according to GeneDecks:

(show all 11)

id	Name	GO ID	Score	Top Affiliating Genes
1	high-density lipoprotein particle	GO:034364	10.0	PON1, APOH, APOE, APOA1, LCAT, LIPC
2	platelet alpha granule lumen	GO:031093	9.9	PROS1, TIMP1, PF4, PPBP, ALB, F8
3	very-low-density lipoprotein particle	GO:034361	9.9	APOH, APOE, APOC3, APOB, APOA1, LPL
4	protein complex	GO:043234	9.9	CXADR, OXA1L, AHSG, TP53, ALB, MEN1
5	chylomicron	GO:042627	9.7	APOH, APOE, APOC3, APOB, LPL
6	cell surface	GO:009986	9.4	GHR, TNF, CR1, PLAT, THBD, TGFA
7	secretory granule	GO:030141	8.9	TF, PLA2G2A, PLAT, GHRL, APOA1, IL1B
8	external side of plasma membrane	GO:009897	8.4	IL2RB, FAS, IFNG, TNF, ACE, ITGB1
9	plasma membrane	GO:005886	5.9	C4B, NOS3, CR1, PTH1R, TNF, GHR
10	extracellular region	GO:005576	4.6	INS, IL1B, IL6, APOA1, APOB, APOC3
11	extracellular space	GO:005615	2.9	EPO, ADIPOQ, REN, APOA1, APOB, APOC3

Biological processes related to uremia according to GeneDecks:

(show top 50)    (show all 55)

id	Name	GO ID	Score	Top Affiliating Genes
1	very-low-density lipoprotein particle remodeling	GO:034372	10.5	APOE, LCAT, LIPC, LPL
2	positive regulation of glucose import	GO:046326	10.4	ADIPOQ, PTH, IGF1, INSR, INS
3	high-density lipoprotein particle remodeling	GO:034375	10.4	APOE, APOC3, APOA1, LCAT, LIPC
4	reverse cholesterol transport	GO:043691	10.4	APOE, APOC3, APOA1, LCAT, LIPC
5	low-density lipoprotein particle remodeling	GO:034374	10.4	AGTR1, AGT, PLA2G2A, APOB, LIPC
6	low-density lipoprotein particle clearance	GO:034383	10.3	ADIPOQ, HMOX1, APOB, LDLR
7	positive regulation of multicellular organism growth	GO:040018	10.3	CSF1, AGT, GHRL, GHR, GH1
8	positive regulation of macrophage derived foam cell differentiation	GO:010744	10.3	CSF1, AGTR1, AGT, PF4, PLA2G2A, APOB
9	lipoprotein metabolic process	GO:042157	10.3	ALB, APOE, APOC3, APOB, APOA1, LCAT
10	cholesterol homeostasis	GO:042632	10.3	APOE, APOC3, APOB, APOA1, LCAT, LDLR
11	cholesterol metabolic process	GO:008203	10.2	SREBF1, APOE, APOC3, APOB, APOA1, LCAT
12	positive regulation of cellular protein metabolic process	GO:032270	10.2	ADIPOQ, CSF1, AGTR1, AGT, INS
13	lipid metabolic process	GO:006629	10.2	SREBF1, ALB, APOE, APOC3, APOB, APOA1
14	positive regulation of cholesterol esterification	GO:010873	10.1	AGTR1, AGT, APOE, APOA1
15	leukocyte migration	GO:050900	10.0	CXADR, PROC, PROS1, THBD, F2, APOB
16	platelet degranulation	GO:002576	10.0	PF4, TIMP1, TF, PROS1, SOD1, PPBP
17	negative regulation of platelet activation	GO:010544	9.9	THBD, NOS3, F2, APOE
18	positive regulation of MAPK cascade	GO:043410	9.9	AGT, IGF1, IL6, INSR, INS, ITGB1
19	response to estradiol stimulus	GO:032355	9.9	NOS3, GHR, GH1, IGFBP2, IL1B, INSR
20	positive regulation of phosphatidylinositol 3-kinase cascade	GO:014068	9.9	AGT, PTK2, GH1, F2, IGF1, INS
21	regulation of blood pressure	GO:008217	9.8	SOD1, ACE, NOS3, HMOX1, CALCA, CHGA
22	negative regulation of blood coagulation	GO:030195	9.7	PROC, THBD, EDN1, APOH, APOE, SERPINE1
23	response to estrogen stimulus	GO:043627	9.7	EPO, CYP27B1, TNFRSF11B, HMOX1, GHRL, CCND1
24	acute-phase response	GO:006953	9.7	AHSG, CRP, F2, F8, IL6, INS
25	negative regulation of fibrinolysis	GO:051918	9.7	SERPINE1, APOH, F2, THBD
26	embryo implantation	GO:007566	9.6	EPO, SOD1, SPP1, CALCA, IL1B
27	aging	GO:007568	9.5	EPO, TIMP1, AGT, NOS3, PTH1R, CALCA
28	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	9.4	ADIPOQ, AGT, TP53, GHR, GH1, IGF1
29	G-protein coupled receptor signaling pathway	GO:007186	9.4	PTH, PTH1R, EDN1, AGT, AGTR1, GHRL
30	activation of MAPK activity	GO:000187	9.3	SOD1, TGFA, TNF, GHRL, GHR, IL1B
31	small molecule metabolic process	GO:044281	9.1	ALAD, ALB, HMOX1, TPMT, CYP27B1, PLA2G6
32	positive regulation of cell migration	GO:030335	9.1	CSF1, EGFR, EDN1, PTK2, INSR, INS
33	positive regulation of mitosis	GO:045840	9.1	INSR, IL1B, IGF1, TNF, EDN1, TGFA
34	positive regulation of protein kinase B signaling cascade	GO:051897	9.0	INS, INSR, IGF1, TNF, PTK2, EGFR
35	regulation of cell proliferation	GO:042127	9.0	AGTR1, AGT, NOS2, PTK2, GHRL, FAS
36	platelet activation	GO:030168	9.0	PPBP, PF4, TIMP1, THPO, TF, PROS1
37	response to hypoxia	GO:001666	8.9	ADIPOQ, EDN1, NOS3, NOS2, PLAT, CRP
38	positive regulation of protein phosphorylation	GO:001934	8.8	ADIPOQ, PTK2, TNF, F2, CCND1, IL1B
39	MAPK cascade	GO:000165	8.7	TGFA, EGFR, TNF, IL1B, MEN1, INS
40	inflammatory response	GO:006954	8.7	SPP1, CRP, C4B, AGER, CSF1, TNF
41	positive regulation of apoptotic process	GO:043065	8.6	ADCY10, SOD1, AGT, NOS3, TNF, TP53
42	positive regulation of chemokine biosynthetic process	GO:045080	8.6	TNF, HMOX1, IFNG, IL1B
43	anti-apoptosis	GO:006916	8.5	HMOX1, TNF, NOS3, TGFA, SOD1, EPO
44	response to glucocorticoid stimulus	GO:051384	8.4	ADIPOQ, PLAT, TNF, GHR, IGFBP2, FAS
45	negative regulation of cell proliferation	GO:008285	8.2	TNF, PTH1R, CYP27B1, NOS3, AGT, TP53
46	positive regulation of cell proliferation	GO:008284	8.2	PTH1R, PTK2, EDN1, EGFR, TIMP1, THPO
47	response to drug	GO:042493	7.9	TNFRSF11B, NOS3, EDN1, ABP1, ACACA, TGFA
48	blood coagulation	GO:007596	7.9	VWF, PPBP, PLAT, NOS2, NOS3, PF4
49	positive regulation of nitric oxide biosynthetic process	GO:045429	7.9	EGFR, INS, INSR, IL1B, IFNG, TNF
50	negative regulation of apoptotic process	GO:043066	7.8	PTK2, PF4, EGFR, TIMP1, PROC, EPO

Molecular functions related to uremia according to GeneDecks:

(show all 9)

id	Name	GO ID	Score	Top Affiliating Genes
1	glycoprotein binding	GO:001948	10.1	VWF, LDLR, ITGAM, ITGB1, APOH, TGFA
2	heparin binding	GO:008201	9.7	ABP1, PF4, APOH, APOE, APOB, LIPC
3	protein homodimerization activity	GO:042803	9.5	ABP1, TKT, OXA1L, SOD1, CSF1, PON1
4	hormone activity	GO:005179	9.5	RETN, EPO, ADIPOQ, THPO, TTR, AGT
5	copper ion binding	GO:005507	9.4	CP, SOD1, ABP1, TP53, ALB, F8
6	protease binding	GO:002020	8.5	TNF, TP53, INS, ITGB1, UBC, SERPINE1
7	growth factor activity	GO:008083	8.5	PPBP, AGT, THPO, TGFA, CSF1, GH1
8	cytokine activity	GO:005125	7.4	ADIPOQ, CSF1, THPO, EDN1, SPP1, TNFRSF11B
9	protein binding	GO:005515	3.7	CRP, PLAT, NOS2, NOS3, EGFR, ACACA