MCID: URM002
MIFTS: 58

Uremia malady

Nephrological diseases category
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Summaries for Uremia

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Wikipedia:65 Uremia or uraemia (see spelling differences) can be translated as \"urea in the blood\". Urea is one of... more...

MalaCards based summary: Uremia, also known as uremia of renal origin, is related to insulin resistance and renal osteodystrophy. An important gene associated with Uremia is EPO (erythropoietin), and among its related pathways are Transcription Role of VDR in regulation of genes involved in osteoporosis and Osteoblast Signaling. The drugs activated charcoal and charcoal and the compounds phenylhydrazine and saci have been mentioned in the context of this disorder. Affiliated tissues include kidney, testes and endothelial, and related mouse phenotypes are liver/biliary system and cellular.

Aliases & Classifications for Uremia

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Sources:
8Disease Ontology, 44Novoseek, 62UMLS, 34MeSH, 57SNOMED-CT
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Uremia, Aliases & Descriptions:

Name: Uremia 8 44 62
Uremia of Renal Origin 8 62
 
Uremia Nos 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological diseases


External Ids:

Disease Ontology8 DOID:4676
MeSH34 D014511

Related Diseases for Uremia

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Diseases related to Uremia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 153)
idRelated DiseaseScoreTop Affiliating Genes
1insulin resistance30.5AHSG, APOC3, RETN
2renal osteodystrophy30.3CASR, PTH, TNFRSF11B
3hemolytic anemia30.3RHD, EPO
4osteosclerosis30.2PTH, TNFRSF11B
5hyperphosphatemia30.1AHSG, TNFRSF11B, PTH, CASR
6rickets30.1PTH, CASR
7hyperparathyroidism30.1TNFRSF11B, PTH, EPO, MEN1, CASR, NR1I3
8atherosclerosis30.0AHSG, TNFRSF11B, APOC3, RETN, CASR
9acromegaly30.0RETN, MEN1
10osteomalacia30.0TNFRSF11B, PTH, CASR
11liver cirrhosis29.9TNFRSF11B, RETN, RHD
12obesity29.7AHSG, APOC3, RETN, NR1I3
13primary hyperparathyroidism29.6PTH, MEN1, CASR, NR1I3
14adenoma29.6NR1I3, CASR, MEN1, PTH
15diabetes mellitus29.3RHD, CASR, RETN, APOC3, PTH, AHSG
16hypertension10.5
17endotheliitis10.4
18rh isoimmunization10.4RHD, EPO
19hepatitis10.4
20neonatal jaundice10.4RHD, NR1I3
21peritonitis10.3
22multiple endocrine neoplasia type 2a10.3MEN1, PTH
23myelofibrosis10.3AHSG, EPO
24sickle cell disease10.3RHD, EPO
25malaria10.3RHD, ALAD
26anuria10.3
27hyperhomocysteinemia10.3
28osteoporosis, postmenopausal10.2PTH, TNFRSF11B
29kidney disease10.2
30ankylosing spondylitis10.2TNFRSF11B, PTH
31pancytopenia10.2EPO, TPMT
32metabolic acidosis10.2
33beta thalassemia10.2TNFRSF11B, EPO, RHD
34osteitis fibrosa10.2CASR, PTH
35lipodystrophy10.1RETN, APOC3
36hyperparathyroidism, neonatal10.1NR1I3, CASR
37calcinosis10.1CASR, PTH
38nephrosclerosis10.1
39arteriosclerosis10.1
40malignant hypertension10.1
41vitiligo mental retardation facial dysmorphism uremia10.1
42autonomic dysfunction10.1
43hyperparathyroidism-jaw tumor syndrome10.1MEN1, CASR
44nephrocalcinosis10.1CASR, NR1I3
45myeloma10.1TNFRSF11B, EPO, RHD
46gastrinoma10.1CASR, MEN1
47thyroid medullary carcinoma10.0MEN1, CASR
48anorexia nervosa10.0RETN, TNFRSF11B
49arteriovenous fistula10.0
50arthritis10.0

Graphical network of the top 20 diseases related to Uremia:



Diseases related to uremia

Symptoms for Uremia

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Drugs & Therapeutics for Uremia

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Drug clinical trials:

Search ClinicalTrials for Uremia

Search NIH Clinical Center for Uremia

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Uremia

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Anatomical Context for Uremia

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MalaCards organs/tissues related to Uremia:

32
Kidney, Testes, Endothelial, Bone, Brain, Heart, Neutrophil, Skeletal muscle, Monocytes, Lung, Smooth muscle, Liver, Pancreas, T cells, B cells, Bone marrow, Small intestine, Colon, Adipocyte, Cervix, Pancreatic islet

Animal Models for Uremia or affiliated genes

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MGI Mouse Phenotypes related to Uremia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053709.0NR1I3, MEN1, RETN, EPO
2MP:00053847.4TNFRSF11B, APOC3, EPO, MEN1, CASR, NR1I3
3MP:00053977.2TNFRSF11B, PTH, APOC3, TPMT, EPO, CASR
4MP:00107687.1TNFRSF11B, PTH, TPMT, EPO, MEN1, CASR
5MP:00053786.8AHSG, TNFRSF11B, PTH, APOC3, TPMT, MEN1
6MP:00053766.3RHD, AHSG, PTH, APOC3, TPMT, EPO

Publications for Uremia

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Articles related to Uremia:

(show top 50)    (show all 608)
idTitleAuthorsYear
1
Serum calcium and bone: effect of PTH, phosphate, vitamin D and uremia. (25259820)
2014
2
Genome-wide analysis of DNA 5-hmC in peripheral blood of uremia by hMeDIP-chip. (24697287)
2014
3
Acute uremia suppresses leucine-induced signal transduction in skeletal muscle. (23783244)
2013
4
Indoxyl sulfate signals for rapid mRNA stabilization of Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 2 (CITED2) and suppresses the expression of hypoxia-inducible genes in experimental CKD and uremia. (23792300)
2013
5
Effects of chronic kidney disease and uremia on hepatic drug metabolism and transport. (24132209)
2013
6
Ghrelin and muscle metabolism in chronic uremia. (22200437)
2012
7
Simultaneous pancreas-kidney transplants are appropriate in insulin-treated candidates with uremia regardless of diabetes type. (21527647)
2011
8
Treatment of cardiovascular calcification in uremia. (21824104)
2011
9
Sex differences in kidney size and clinical features of patients with uremia. (21056871)
2010
10
Ultrastructural analysis of vascular calcifications in uremia. (20203159)
2010
11
ACE inhibition attenuates uremia-induced aortic valve thickening in a novel mouse model. (19257900)
2009
12
C-reactive protein and uremia. (19708997)
2009
13
Severe hemolytic uremia syndrome and antiphospholipid antibodies following bowel infection in the absence of major vascular occlusions: an example of MAPS? (19160952)
2008
14
Uremia-related vascular calcification: more than apatite deposition. (17149373)
2007
15
Brain dysfunction in uremia: a question of cortical hyperexcitability? (15908270)
2005
16
Oxidative stress and uremia. (15660443)
2005
17
IL-10, IL-6, and TNF-alpha: central factors in the altered cytokine network of uremia--the good, the bad, and the ugly. (15780075)
2005
18
Mechanisms of vascular calcification in uremia. (15490398)
2004
19
Monocyte apoptosis in uremia is normalized with continuous blood purification modalities. (14732806)
2004
20
Eating behavior disorders in uremia: a question of balance in appetite regulation. (14717811)
2004
21
Acute uremia produced in rats by nephrotoxic chemicals is alleviated by protein deficient diet. (12911155)
2003
22
Renin-angiotensin gene polymorphism in children with uremia and essential hypertension. (12579405)
2003
23
Efficacy of 19-Nor-1,25-(OH)2D2 in the prevention and treatment of hyperparathyroid bone disease in experimental uremia. (12753289)
2003
24
Chronic uremia induces permeability changes, increased nitric oxide synthase expression, and structural modifications in the peritoneum. (11562414)
2001
25
MAPnckeberg's medial sclerosis and inorganic phosphate in uremia. (11576921)
2001
26
Coronary artery disease in uremia: Etiology, diagnosis, and therapy. (11737581)
2001
27
Selection bias impacts outcome reports of uremia therapy. (10873894)
2000
28
B lymphopenia in uremia is related to an accelerated in vitro apoptosis and dysregulation of Bcl-2. (10727545)
2000
29
Serum lipids status in patients with diabetic uremia on 10 years of maintenance hemodialysis. (10412780)
1999
30
Introduction to renal osteodystrophy: calcium metabolism in health and uremia. (10372833)
1999
31
Alterations in nonenzymatic biochemistry in uremia: origin and significance of "carbonyl stress" in long-term uremic complications. (9987064)
1999
32
Medical management of secondary hyperparathyroidism in uremia. (10372838)
1999
33
Modulation of parathyroid cell function by calcium ion in health and uremia. (10372834)
1999
34
Acute movement disorders with bilateral basal ganglia lesions in uremia. (9827621)
1998
35
Imidazolium crosslinks derived from reaction of lysine with glyoxal and methylglyoxal are increased in serum proteins of uremic patients: evidence for increased oxidative stress in uremia. (9637262)
1998
36
Effects of benazepril on insulin resistance and glucose tolerance in uremia. (9725782)
1998
37
Effect of metabolic acidosis on insulin action and secretion in uremia. (9690228)
1998
38
The use of the artificial kidney in the treatment of uremia. 1952. (9854252)
1998
39
Use of recombinant human erythropoietin outside the setting of uremia. (9192747)
1997
40
The parathyroid-bone axis in uremia: new insights into old questions. (9051353)
1997
41
Enrollment parathyroid hormone level is a new marker of survival in hemodialysis and peritoneal dialysis therapy for uremia. (8957048)
1996
42
Dysfunction of polymorphonuclear leukocytes in uremia. (8734462)
1996
43
Reactivity to hepatitis B vaccination (HBV) in patients with uremia: association with defined HLA antigen configuration and complement protein allotypes C4A, C4B and B factor (Bf)]. (8834646)
1995
44
The rate and control of baseline red cell production in hematologically stable patients with uremia. (7665976)
1995
45
Reduced production, absorption, and elimination of erythropoietin in uremia compared with healthy volunteers. (7993997)
1994
46
Myocardial texture and cardiac calcification in uremia. (8345830)
1993
47
Growth hormone metabolism in uremia. (1777890)
1991
48
Progression to uremia after remission of acute poststreptococcal glomerulonephritis. (787789)
1976
49
The influence of uremia upon renal hypertension. (5438011)
1970
50
Uremia and disseminated platelet-cell (thrombocyte) thrombosis; report of a case due to malignant nephrosclerosis with acute pancreatitis. (14914218)
1952

Variations for Uremia

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Expression for genes affiliated with Uremia

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Expression patterns in normal tissues for genes affiliated with Uremia

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Pathways for genes affiliated with Uremia

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Pathways related to Uremia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7PTH, TNFRSF11B
29.7PTH, TNFRSF11B

Compounds for genes affiliated with Uremia

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Compounds related to Uremia according to GeneCards/GeneDecks:

(show top 50)    (show all 71)
idCompoundScoreTop Affiliating Genes
1phenylhydrazine4410.3EPO, RHD
2saci4410.1AHSG, APOC3
3succinylacetone4410.0ALAD, EPO
4zinc protoporphyrin449.9EPO, ALAD
5hydroxyproline44 24 1111.7PTH, TNFRSF11B, AHSG
6gadolinium449.6CASR, NR1I3
7cinacalcet44 28 1111.6CASR, NR1I3
8strontium449.5TNFRSF11B, CASR
9protoporphyrin ix44 24 1111.5ALAD, EPO
10ethanol44 50 24 1112.5RHD, NR1I3, ALAD, AHSG
11dhea449.4TNFRSF11B, RETN, NR1I3
12thymidine44 2410.4PTH, EPO, MEN1, NR1I3
13neomycin449.4EPO, CASR, NR1I3
14azathioprine44 2 50 1112.4EPO, TPMT, TNFRSF11B
15urea44 24 1111.3TNFRSF11B, EPO, RETN
16xbai449.3CASR, APOC3, AHSG
17pamidronate44 50 1111.3CASR, PTH, TNFRSF11B
1825-hydroxyvitamin d449.2CASR, PTH, TNFRSF11B
19iron44 2410.2RHD, ALAD, EPO, TNFRSF11B
20p002449.2TNFRSF11B, APOC3, RETN
21atorvastatin44 50 28 24 1113.2RETN, APOC3, TNFRSF11B
22hydroxyapatite449.2CASR, TNFRSF11B, AHSG
23thyroxine44 2410.2RETN, PTH, TNFRSF11B
24homocysteine44 2410.1RHD, RETN, APOC3, TNFRSF11B
25fibrinogen449.0AHSG, TNFRSF11B, APOC3, RETN
26aspartate449.0RHD, RETN, EPO, TNFRSF11B
27phosphorus448.9TNFRSF11B, PTH, CASR, NR1I3
281,25 dihydroxy vitamin d3448.9TNFRSF11B, PTH, CASR, NR1I3
29inositol 1,4,5 trisphosphate448.9PTH, CASR, NR1I3
30vegf448.8MEN1, RETN, EPO, PTH, TNFRSF11B
31estradiol44 24 1110.8TNFRSF11B, PTH, RETN, ALAD, NR1I3
32calcitriol44 61 24 1111.7TNFRSF11B, PTH, EPO, CASR, NR1I3
33cholesterol44 28 24 1111.6NR1I3, RETN, APOC3, TNFRSF11B
34forskolin44 50 1110.6TNFRSF11B, PTH, RETN, CASR
35magnesium44 24 1110.5TNFRSF11B, PTH, CASR, ALAD, NR1I3
36lysine448.5RHD, NR1I3, ALAD, CASR, TNFRSF11B
37sodium44 249.4TNFRSF11B, PTH, RETN, CASR, NR1I3
38steroid448.4TNFRSF11B, APOC3, TPMT, RETN, NR1I3
39lipid448.3TNFRSF11B, APOC3, RETN, ALAD, NR1I3, RHD
40cyclosporin a44 28 6110.3TNFRSF11B, TPMT, EPO, CASR, NR1I3
41atp44 289.3TNFRSF11B, PTH, APOC3, TPMT, ALAD, RHD
42testosterone44 61 24 1111.1TNFRSF11B, PTH, APOC3, EPO, RETN, ALAD
43serine448.0TNFRSF11B, APOC3, MEN1, CASR, NR1I3, RHD
44nitric oxide44 24 119.9TNFRSF11B, PTH, APOC3, RETN, CASR, ALAD
45glucose447.7AHSG, TNFRSF11B, PTH, APOC3, RETN, CASR
46vitamin d447.6AHSG, TNFRSF11B, PTH, EPO, MEN1, CASR
47estrogen447.3AHSG, TNFRSF11B, PTH, APOC3, RETN, MEN1
48creatinine447.0TNFRSF11B, PTH, APOC3, TPMT, EPO, RETN
49calcium44 50 24 1110.0AHSG, TNFRSF11B, PTH, RETN, MEN1, CASR
50tyrosine445.7RHD, AHSG, TNFRSF11B, PTH, APOC3, TPMT

GO Terms for genes affiliated with Uremia

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Cellular components related to Uremia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.6AHSG, TNFRSF11B, PTH, APOC3, EPO
2extracellular spaceGO:0056157.8AHSG, TNFRSF11B, PTH, APOC3, EPO, RETN

Biological processes related to Uremia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to estrogenGO:0436279.7EPO, TNFRSF11B
2response to testosteroneGO:0335749.6TPMT, EPO
3skeletal system developmentGO:0015019.4PTH, TNFRSF11B, AHSG
4response to drugGO:0424939.1APOC3, PTH, TNFRSF11B
5G-protein coupled receptor signaling pathwayGO:0071868.6PTH, APOC3, CASR

Molecular functions related to Uremia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.4RETN, EPO, PTH

Products for genes affiliated with Uremia

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  • Antibodies
  • Proteins
  • Lysates

Sources for Uremia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet