MCID: URM002
MIFTS: 55

Uremia malady

Nephrological diseases category

Summaries for Uremia

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Wikipedia:65 Uremia or uraemia (see spelling differences) can be translated as \"urea in the blood\". Urea is one of... more...

MalaCards based summary: Uremia, also known as uremia of renal origin, is related to atherosclerosis and hyperparathyroidism. An important gene associated with Uremia is EPO (erythropoietin), and among its related pathways are Transcription Role of VDR in regulation of genes involved in osteoporosis and Osteoblast Signaling. The drugs activated charcoal and charcoal and the compounds phenylhydrazine and saci have been mentioned in the context of this disorder. Affiliated tissues include kidney, testes and endothelial, and related mouse phenotypes are liver/biliary system and cellular.

Aliases & Classifications for Uremia

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Sources:
10Disease Ontology, 45Novoseek, 62UMLS, 57SNOMED-CT, 35MeSH
See all sources

Uremia, Aliases & Descriptions:

Name: Uremia 10 45 62
 
Uremia of Renal Origin 10 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological diseases


External Ids:

Disease Ontology10 DOID:4676
MeSH35 D014511

Related Diseases for Uremia

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Diseases related to Uremia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 147)
idRelated DiseaseScoreTop Affiliating Genes
1atherosclerosis30.7AHSG, TNFRSF11B, APOC3, RETN, CASR
2hyperparathyroidism30.7TNFRSF11B, PTH, EPO, MEN1, CASR, NR1I3
3renal osteodystrophy30.3CASR, PTH, TNFRSF11B
4kidney disease30.3CASR, TNFRSF11B, AHSG
5hyperphosphatemia30.3AHSG, TNFRSF11B, PTH, CASR
6osteomalacia30.0TNFRSF11B, PTH, CASR
7hemolytic anemia29.9RHD, EPO
8rickets29.9PTH, CASR
9acromegaly29.9RETN, MEN1
10liver cirrhosis29.8TNFRSF11B, RETN, RHD
11coronary artery disease29.8TNFRSF11B, APOC3, RETN
12obesity29.8AHSG, APOC3, RETN, NR1I3
13primary hyperparathyroidism29.8PTH, MEN1, CASR, NR1I3
14adenoma29.8NR1I3, CASR, MEN1, PTH
15endotheliitis10.5
16hepatitis10.4
17peritonitis10.4
18anuria10.3
19hyperhomocysteinemia10.3
20metabolic acidosis10.2
21nephrosclerosis10.1
22cerebritis10.1
23arteriosclerosis10.1
24malignant hypertension10.1
25vitiligo mental retardation facial dysmorphism uremia10.1
26autonomic dysfunction10.1
27rh isoimmunization10.0RHD, EPO
28rheumatoid arthritis10.0
29hepatocellular carcinoma10.0
30arteriovenous fistula10.0
31arthritis10.0
32glomerulonephritis10.0
33thrombocytopenia10.0
34cardiac tamponade10.0
35hepatic coma10.0
36nephronophthisis10.0
37bronchopneumonia10.0
38neuropathy10.0
39pancreatitis10.0
40vascular disease10.0
41prurigo nodularis10.0
42cerebral atrophy10.0
43headache10.0
44hypoxia10.0
45nephrosis10.0
46neonatal jaundice10.0RHD, NR1I3
47multiple endocrine neoplasia iia10.0MEN1, PTH
48myelofibrosis10.0AHSG, EPO
49sickle cell disease10.0RHD, EPO
50malaria10.0RHD, ALAD

Graphical network of the top 20 diseases related to Uremia:



Diseases related to uremia

Symptoms for Uremia

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Drugs & Therapeutics for Uremia

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Drug clinical trials:

Search ClinicalTrials for Uremia

Search NIH Clinical Center for Uremia

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Uremia

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Anatomical Context for Uremia

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MalaCards organs/tissues related to Uremia:

33
Kidney, Testes, Endothelial, Bone, Brain, Heart, Neutrophil, Skeletal muscle, Monocytes, Lung, Pancreas, Smooth muscle, Liver, T cells, B cells, Bone marrow, Small intestine, Colon, Adipocyte, Cervix, Pancreatic islet

Animal Models for Uremia or affiliated genes

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MGI Mouse Phenotypes related to Uremia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053709.0NR1I3, MEN1, RETN, EPO
2MP:00053847.4TNFRSF11B, APOC3, EPO, MEN1, CASR, NR1I3
3MP:00053977.2TNFRSF11B, PTH, APOC3, TPMT, EPO, CASR
4MP:00107687.1TNFRSF11B, PTH, TPMT, EPO, MEN1, CASR
5MP:00053786.8AHSG, TNFRSF11B, PTH, APOC3, TPMT, MEN1
6MP:00053766.3RHD, AHSG, PTH, APOC3, TPMT, EPO

Publications for Uremia

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Articles related to Uremia:

(show top 50)    (show all 617)
idTitleAuthorsYear
1
Intratympanic steroid injection as a first-line therapy in uremia patients with sudden sensorineural hearing loss. (25783847)
2015
2
Serum calcium and bone: effect of PTH, phosphate, vitamin D and uremia. (25259820)
2014
3
Simultaneous pancreas and kidney transplantation for liver transplant recipients with diabetes and uremia. (25457347)
2014
4
Genome-wide analysis of DNA 5-hmC in peripheral blood of uremia by hMeDIP-chip. (24697287)
2014
5
Acute uremia suppresses leucine-induced signal transduction in skeletal muscle. (23783244)
2013
6
Indoxyl sulfate signals for rapid mRNA stabilization of Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 2 (CITED2) and suppresses the expression of hypoxia-inducible genes in experimental CKD and uremia. (23792300)
2013
7
Effects of chronic kidney disease and uremia on hepatic drug metabolism and transport. (24132209)
2013
8
Ghrelin and muscle metabolism in chronic uremia. (22200437)
2012
9
Simultaneous pancreas-kidney transplants are appropriate in insulin-treated candidates with uremia regardless of diabetes type. (21527647)
2011
10
Treatment of cardiovascular calcification in uremia. (21824104)
2011
11
Sex differences in kidney size and clinical features of patients with uremia. (21056871)
2010
12
Ultrastructural analysis of vascular calcifications in uremia. (20203159)
2010
13
ACE inhibition attenuates uremia-induced aortic valve thickening in a novel mouse model. (19257900)
2009
14
C-reactive protein and uremia. (19708997)
2009
15
Severe hemolytic uremia syndrome and antiphospholipid antibodies following bowel infection in the absence of major vascular occlusions: an example of MAPS? (19160952)
2008
16
Uremia-related vascular calcification: more than apatite deposition. (17149373)
2007
17
Brain dysfunction in uremia: a question of cortical hyperexcitability? (15908270)
2005
18
Oxidative stress and uremia. (15660443)
2005
19
IL-10, IL-6, and TNF-alpha: central factors in the altered cytokine network of uremia--the good, the bad, and the ugly. (15780075)
2005
20
Mechanisms of vascular calcification in uremia. (15490398)
2004
21
Monocyte apoptosis in uremia is normalized with continuous blood purification modalities. (14732806)
2004
22
Eating behavior disorders in uremia: a question of balance in appetite regulation. (14717811)
2004
23
Acute uremia produced in rats by nephrotoxic chemicals is alleviated by protein deficient diet. (12911155)
2003
24
Renin-angiotensin gene polymorphism in children with uremia and essential hypertension. (12579405)
2003
25
Efficacy of 19-Nor-1,25-(OH)2D2 in the prevention and treatment of hyperparathyroid bone disease in experimental uremia. (12753289)
2003
26
Homocysteine in uremia. (12612968)
2003
27
Chronic uremia induces permeability changes, increased nitric oxide synthase expression, and structural modifications in the peritoneum. (11562414)
2001
28
MAPnckeberg's medial sclerosis and inorganic phosphate in uremia. (11576921)
2001
29
Coronary artery disease in uremia: Etiology, diagnosis, and therapy. (11737581)
2001
30
Selection bias impacts outcome reports of uremia therapy. (10873894)
2000
31
Serum lipids status in patients with diabetic uremia on 10 years of maintenance hemodialysis. (10412780)
1999
32
Introduction to renal osteodystrophy: calcium metabolism in health and uremia. (10372833)
1999
33
Alterations in nonenzymatic biochemistry in uremia: origin and significance of "carbonyl stress" in long-term uremic complications. (9987064)
1999
34
Medical management of secondary hyperparathyroidism in uremia. (10372838)
1999
35
Modulation of parathyroid cell function by calcium ion in health and uremia. (10372834)
1999
36
Acute movement disorders with bilateral basal ganglia lesions in uremia. (9827621)
1998
37
Imidazolium crosslinks derived from reaction of lysine with glyoxal and methylglyoxal are increased in serum proteins of uremic patients: evidence for increased oxidative stress in uremia. (9637262)
1998
38
Effects of benazepril on insulin resistance and glucose tolerance in uremia. (9725782)
1998
39
Effect of metabolic acidosis on insulin action and secretion in uremia. (9690228)
1998
40
Use of recombinant human erythropoietin outside the setting of uremia. (9192747)
1997
41
The parathyroid-bone axis in uremia: new insights into old questions. (9051353)
1997
42
Enrollment parathyroid hormone level is a new marker of survival in hemodialysis and peritoneal dialysis therapy for uremia. (8957048)
1996
43
Reactivity to hepatitis B vaccination (HBV) in patients with uremia: association with defined HLA antigen configuration and complement protein allotypes C4A, C4B and B factor (Bf)]. (8834646)
1995
44
The rate and control of baseline red cell production in hematologically stable patients with uremia. (7665976)
1995
45
Reduced production, absorption, and elimination of erythropoietin in uremia compared with healthy volunteers. (7993997)
1994
46
Myocardial texture and cardiac calcification in uremia. (8345830)
1993
47
Growth hormone metabolism in uremia. (1777890)
1991
48
Progression to uremia after remission of acute poststreptococcal glomerulonephritis. (787789)
1976
49
The influence of uremia upon renal hypertension. (5438011)
1970
50
Uremia and disseminated platelet-cell (thrombocyte) thrombosis; report of a case due to malignant nephrosclerosis with acute pancreatitis. (14914218)
1952

Variations for Uremia

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Expression for genes affiliated with Uremia

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Search GEO for disease gene expression data for Uremia.

Pathways for genes affiliated with Uremia

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Pathways related to Uremia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7PTH, TNFRSF11B
29.7PTH, TNFRSF11B

Compounds for genes affiliated with Uremia

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Compounds related to Uremia according to GeneCards/GeneDecks:

(show top 50)    (show all 71)
idCompoundScoreTop Affiliating Genes
1phenylhydrazine4510.3EPO, RHD
2saci4510.1AHSG, APOC3
3succinylacetone4510.0ALAD, EPO
4zinc protoporphyrin459.9EPO, ALAD
5hydroxyproline45 26 1311.7PTH, TNFRSF11B, AHSG
6gadolinium459.6CASR, NR1I3
7cinacalcet45 30 1311.6CASR, NR1I3
8strontium459.5TNFRSF11B, CASR
9protoporphyrin ix45 26 1311.5ALAD, EPO
10ethanol45 51 26 1312.5RHD, NR1I3, ALAD, AHSG
11dhea459.4TNFRSF11B, RETN, NR1I3
12thymidine45 2610.4PTH, EPO, MEN1, NR1I3
13neomycin459.4EPO, CASR, NR1I3
14azathioprine45 3 51 1312.4EPO, TPMT, TNFRSF11B
15urea45 26 1311.3TNFRSF11B, EPO, RETN
16xbai459.3CASR, APOC3, AHSG
17pamidronate45 51 1311.3CASR, PTH, TNFRSF11B
1825-hydroxyvitamin d459.2CASR, PTH, TNFRSF11B
19iron45 2610.2RHD, ALAD, EPO, TNFRSF11B
20p002459.2TNFRSF11B, APOC3, RETN
21atorvastatin45 51 30 26 1313.2RETN, APOC3, TNFRSF11B
22hydroxyapatite459.2CASR, TNFRSF11B, AHSG
23thyroxine45 2610.2RETN, PTH, TNFRSF11B
24homocysteine45 2610.1RHD, RETN, APOC3, TNFRSF11B
25fibrinogen459.0AHSG, TNFRSF11B, APOC3, RETN
26aspartate459.0RHD, RETN, EPO, TNFRSF11B
27phosphorus458.9TNFRSF11B, PTH, CASR, NR1I3
281,25 dihydroxy vitamin d3458.9TNFRSF11B, PTH, CASR, NR1I3
29inositol 1,4,5 trisphosphate458.9PTH, CASR, NR1I3
30vegf458.8MEN1, RETN, EPO, PTH, TNFRSF11B
31estradiol45 26 1310.8TNFRSF11B, PTH, RETN, ALAD, NR1I3
32calcitriol45 61 26 1311.7TNFRSF11B, PTH, EPO, CASR, NR1I3
33cholesterol45 30 26 1311.6NR1I3, RETN, APOC3, TNFRSF11B
34forskolin45 51 1310.6TNFRSF11B, PTH, RETN, CASR
35magnesium45 26 1310.5TNFRSF11B, PTH, CASR, ALAD, NR1I3
36lysine458.5RHD, NR1I3, ALAD, CASR, TNFRSF11B
37sodium45 269.4TNFRSF11B, PTH, RETN, CASR, NR1I3
38steroid458.4TNFRSF11B, APOC3, TPMT, RETN, NR1I3
39lipid458.3TNFRSF11B, APOC3, RETN, ALAD, NR1I3, RHD
40cyclosporin a45 30 6110.3TNFRSF11B, TPMT, EPO, CASR, NR1I3
41atp45 309.3TNFRSF11B, PTH, APOC3, TPMT, ALAD, RHD
42testosterone45 61 26 1311.1TNFRSF11B, PTH, APOC3, EPO, RETN, ALAD
43serine458.0TNFRSF11B, APOC3, MEN1, CASR, NR1I3, RHD
44nitric oxide45 26 139.9TNFRSF11B, PTH, APOC3, RETN, CASR, ALAD
45glucose457.7AHSG, TNFRSF11B, PTH, APOC3, RETN, CASR
46vitamin d457.6AHSG, TNFRSF11B, PTH, EPO, MEN1, CASR
47estrogen457.3AHSG, TNFRSF11B, PTH, APOC3, RETN, MEN1
48creatinine457.0TNFRSF11B, PTH, APOC3, TPMT, EPO, RETN
49calcium45 51 26 1310.0AHSG, TNFRSF11B, PTH, RETN, MEN1, CASR
50tyrosine455.7RHD, AHSG, TNFRSF11B, PTH, APOC3, TPMT

GO Terms for genes affiliated with Uremia

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Cellular components related to Uremia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055768.6EPO, APOC3, PTH, TNFRSF11B, AHSG
2extracellular spaceGO:00056157.8RETN, AHSG, TNFRSF11B, PTH, APOC3, EPO

Biological processes related to Uremia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to estrogenGO:00436279.7EPO, TNFRSF11B
2response to testosteroneGO:00335749.6EPO, TPMT
3skeletal system developmentGO:00015019.4PTH, TNFRSF11B, AHSG
4response to drugGO:00424939.1TNFRSF11B, PTH, APOC3
5G-protein coupled receptor signaling pathwayGO:00071868.6CASR, APOC3, PTH

Molecular functions related to Uremia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00051799.4RETN, EPO, PTH

Products for genes affiliated with Uremia

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Sources for Uremia

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet