MCID: URM002
MIFTS: 54

Uremia malady

Nephrological category

Summaries for Uremia

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Uremia or uraemia (see spelling differences) is the illness accompanying kidney failure (also called... more...

MalaCards: Uremia, also known as uremia of renal origin, is related to atherosclerosis and insulin resistance. An important gene associated with Uremia is EPO (erythropoietin), and among its related pathways is Osteoblast Signaling. The drugs activated charcoal and charcoal and the compounds tyrosine and calcium have been mentioned in the context of this disorder. Affiliated tissues include liver, brain and kidney, and related mouse phenotypes are immune system and hematopoietic system.

Aliases & Classifications for Uremia

Sources:
8Disease Ontology, 45Novoseek, 61UMLS, 35MeSH, 57SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological


Aliases & Descriptions:

uremia 8 45 61
uremia of renal origin 8
uremia nos 8


External Ids:

Disease Ontology8 DOID:4676
MeSH35 D014511

Related Diseases for Uremia

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Uremia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 172)
idRelated DiseaseScoreTop Affiliating Genes
1atherosclerosis30.7RETN, AOC3, CASR, PF4, AHSG, AGER
2insulin resistance30.5AGER, AOC3, IGFBP2, RETN, APOC3, AHSG
3hyperhomocysteinemia30.4RHD
4vascular disease30.3RETN, AOC3, OXA1L, AGER, ITGAM, TNFRSF11B
5renal osteodystrophy30.3CASR, PTH, TNFRSF11B
6hyperphosphatemia30.3PTH, AHSG, TNFRSF11B, CASR
7arthritis30.0AMBP, TNFRSF11B, ITGAM, AGER, RETN, AOC3
8osteomalacia30.0PTH, CASR, TNFRSF11B
9diabetic nephropathy30.0AMBP, OXA1L, EPO, AGER
10thrombocytopenia30.0PF4, TPMT, EPO
11coronary heart disease29.8ITGAM, AGER, OXA1L, PF4, RETN, APOC3
12primary hyperparathyroidism29.8PTH, MEN1, CASR, NR1I3
13osteoarthritis29.8IGFBP2, RETN, AGER, TNFRSF11B
14coronary artery disease,29.8APOC3, AGER, PF4, RETN, TNFRSF11B
15sepsis29.8OXA1L, AMBP, ITGAM, IGFBP2, RETN
16parathyroid carcinoma29.8CASR, PTH, MEN1
17acromegaly29.8MEN1, RETN, IGFBP2
18adenoma29.8CASR, MEN1, NR1I3, PTH, IGFBP2
19hepatitis b29.8OXA1L, RHD
20multiple endocrine neoplasia29.8MEN1
21acute pancreatitis29.8ITGAM, RETN
22rickets29.8PTH, CASR
23anuria10.3
24metabolic acidosis10.2
25nephrosclerosis10.1
26arteriosclerosis10.1
27vitiligo mental retardation facial dysmorphism uremia10.1
28autonomic dysfunction10.1
29cardiac tamponade10.0
30hepatitis c10.0
31nephronophthisis10.0
32bronchopneumonia10.0
33hepatic coma10.0
34prurigo nodularis10.0
35cerebral atrophy10.0
36chorea10.0
37headache10.0
38hypoxia10.0
39nephrosis10.0
40chronic kidney failure10.0RHD, ITGAM, MEN1, TNFRSF11B, CASR, RETN
41diabetes mellitus10.0AHSG, PF4, RETN, PTH, OXA1L, IGFBP2
42secondary hyperparathyroidism of renal origin10.0MEN1, EPO, TNFRSF11B, PTH, CASR, NR1I3
43leukemia10.0IGFBP2, EPO, RHD, ITGAM, PF4, GLO1
44breast cancer10.0OXA1L, PTH, CASR, IGFBP2, NR1I3, MEN1
45obesity10.0APOC3, RETN, AHSG, IGFBP2, AGER, NR1I3
46osteoporosis10.0AHSG, CASR, TNFRSF11B, NR1I3, IGFBP2, PTH
47rheumatoid arthritis10.0TPMT, RETN, PF4, AMBP, AGER, TNFRSF11B
48myeloma10.0PF4, RHD, EPO, OXA1L, TNFRSF11B, ITGAM
49hyperparathyroidism10.0EPO, NR1I3, MEN1, TNFRSF11B, PTH, CASR
50galactosemia10.0TPMT, ALAD, APOC3, OXA1L, NR1I3, AOC3

Graphical network of the top 20 diseases related to Uremia:



Diseases related to uremia

Clinical Features for Uremia

Drugs & Therapeutics for Uremia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Uremia

Drug clinical trials:

Search ClinicalTrials for Uremia

Search NIH Clinical Center for Uremia

Search CenterWatch for Uremia

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Uremia

Anatomical Context for Uremia

Sources:
33MalaCards
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MalaCards organs/tissues related to Uremia:

33
Liver, Brain, Kidney, Lung, Bone marrow, Heart, Smooth muscle, Skeletal muscle, Small intestine, Colon, Adipocyte, Pancreas, Salivary gland, Cervix, Monocytes, T cells, B cells, Endothelial, Pancreatic islet

Animal Models for Uremia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Uremia

Sources:
51PubMed
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Articles related to Uremia:

(show top 50)    (show all 599)
idTitleAuthorsYear
1
Effects of chronic kidney disease and uremia on hepatic drug metabolism and transport. (24132209)
2013
2
Gastric acid secretion in experimental acute uremia. (23984953)
2013
3
Post-transcriptional nature of uremia-induced downregulation of hepatic apolipoprotein A-I production. (23219399)
2013
4
An ethnomedicine study among women in Uremia (North-West Iran). (22856235)
2012
5
High incidence of hepatocellular carcinoma in ESRD patients: caused by high hepatitis rate or 'uremia'? a population-based study. (22782961)
2012
6
Assessment of left ventricular hemodynamics and function of patients with uremia by vortex formation using vector flow mapping. (22694735)
2012
7
Acute movement disorder with bilateral basal ganglia lesions in diabetic uremia. (22028539)
2011
8
Simultaneous robot-assisted nephroureterectomy and cystectomy in patients with uremia and multifocal urothelial carcinoma. (21476927)
2011
9
Hydrogen sulfide, a toxic gas with cardiovascular properties in uremia: how harmful is it? (21228576)
2011
10
ApoA-1 mimetic peptide reverses uremia-induced upregulation of pro-atherogenic pathways in the aorta. (20639628)
2010
11
Aggressive approach in a case of cancer cervix with uremia. (20859473)
2010
12
Uremia impacts renal inflammatory cytokine gene expression in the setting of experimental acute kidney injury. (19656911)
2009
13
Follow-up of kidney donors who developed uremia and went on the waiting list for a transplant: should they have allocation priority? (18555102)
2008
14
GC-MS with ethyl chloroformate derivatization for comprehensive analysis of metabolites in serum and its application to human uremia. (18622754)
2008
15
Uremia-related vascular calcification: more than apatite deposition. (17149373)
2007
16
Regulation of parathyroid hormone mRNA stability by calcium, phosphate and uremia. (17565271)
2007
17
Acute uremia but not renal inflammation attenuates aseptic acute lung injury: a critical role for uremic neutrophils. (17035612)
2006
18
A critical assessment of uremia research. (16361845)
2006
19
Arteriosclerosis, calcium phosphate deposition and cardiovascular disease in uremia: current concepts at the bench. (16205469)
2005
20
Prevention of extraskeletal calcifications in uremia]. (15786403)
2005
21
In uremia, plasma levels of anti-protein C and anti-protein S antibodies are associated with thrombosis. (16105054)
2005
22
Diabetes and atherosclerotic coronary damage in uremia]. (15356846)
2004
23
Uremia and insulin resistance: N-carbamoyl-asparagine decreases insulin-sensitive glucose uptake in rat adipocytes. (14871407)
2004
24
Vascular biology in uremia: insights into novel mechanisms of vascular injury. (15241745)
2004
25
Renin-angiotensin gene polymorphism in children with uremia and essential hypertension. (12579405)
2003
26
Relationship between left ventricular mass, uremia, hypertension and vagal tachycardic reserve. (14508206)
2003
27
Acute uremia in rats: feeding sucrose overnight is preferable to starvation. (12071587)
2002
28
Chronic uremia induces permeability changes, increased nitric oxide synthase expression, and structural modifications in the peritoneum. (11562414)
2001
29
Defects in B-cell function and metabolism in uremia: role of parathyroid hormone. (11169008)
2001
30
Autonomic dysfunction in uremia. (11576936)
2001
31
Preliminary evaluation of neuroendocrine cells in the respiratory tract in rats with experimental uremia. (11374827)
2001
32
Vitamin D analogs in uremia: integrating medical and nutritional issues. (11172447)
2001
33
Increased Fas antigen in uremia accelerates adhesion of mononuclear cells to endothelial and sinovial cells via stimulated hyaluronan production. (11576923)
2001
34
Proceedings of the Second International Congress on Uremia Research. April 26-28, 2001. Nara, Japan. (11576911)
2001
35
Effects of kidney-pancreas transplantation on atherosclerotic risk factors and endothelial function in patients with uremia and type 1 diabetes. (11246868)
2001
36
Dietary therapy in uremia: the impact on nutrition and progressive renal failure. (10828760)
2000
37
Modification of lipoproteins in uremia: oxidation, glycation and carbamoylation. (10681650)
1999
38
Valproic acid intoxication in a patient with bipolar disorder and chronic uremia. (10097841)
1999
39
Mechanisms contributing to muscle-wasting in acute uremia: activation of amino acid catabolism. (9513906)
1998
40
Hemostatic problems in uremia. (9736791)
1998
41
Correction of anemia by erythropoietin reverses insulin resistance and hyperinsulinemia in uremia. (8928846)
1996
42
Reactivity to hepatitis B vaccination (HBV) in patients with uremia: association with defined HLA antigen configuration and complement protein allotypes C4A, C4B and B factor (Bf)]. (8834646)
1995
43
Secondary hyperparathyroidism and tertiary hyperparathyroidism chronic renal failure, uremia]. (7752492)
1995
44
Reduced production, absorption, and elimination of erythropoietin in uremia compared with healthy volunteers. (7993997)
1994
45
Change of platelet function after the beginning of repeated hemodialysis treatment in patients with uremia]. (7716051)
1994
46
Effect of desmopressin (DDAVP) on protein C and protein C inhibitors in uremia. (8321356)
1993
47
Plasma parameters of the prothrombotic state in chronic uremia. (8446263)
1993
48
Reflex anuria and uremia from unilateral ureteral obstruction. (8250035)
1993
49
Prevention of phosphate retention and hyperphosphatemia in uremia. (3323615)
1987
50
Hemopericardium with cardiac tamponade in chronic uremia. (13452081)
1957

Genetic Variations for Uremia

Expression for genes affiliated with Uremia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Uremia

Search GEO for disease gene expression data for Uremia.

Pathways for genes affiliated with Uremia

Sources:
38NCBI BioSystems Database
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Pathways related to Uremia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.5PTH, TNFRSF11B

Compounds for genes affiliated with Uremia

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB, 29IUPHAR, 60Tocris Bioscience
See all sources

Compounds related to Uremia according to GeneCards/GeneDecks:

(show top 50)    (show all 108)
idCompoundScoreTop Affiliating Genes
1tyrosine4511.2TPMT, ALAD, PTH, RETN, PF4, AHSG
2calcium45 50 11 2414.1AGER, ITGAM, AOC3, RHD, TNFRSF11B, IGFBP2
3creatinine4511.1PTH, ALAD, TPMT, RETN, PF4, EPO
4lipid4511.1TNFRSF11B, GLO1, AMBP, RHD, ITGAM, AOC3
5glucose4511.1AMBP, CASR, APOC3, ITGAM, RHD, IGFBP2
6vitamin d4511.1MEN1, NR1I3, TNFRSF11B, CASR, EPO, AHSG
7nitric oxide45 11 2413.1RETN, PTH, AGER, GLO1, CASR, TNFRSF11B
8oxygen45 2412.1RHD, NR1I3, AGER, IGFBP2, EPO, PF4
9fibrinogen4511.0AMBP, AHSG, TNFRSF11B, RETN, APOC3, IGFBP2
10vegf4511.0ITGAM, MEN1, TNFRSF11B, PTH, AGER, RETN
11cholesterol45 29 11 2414.0IGFBP2, PF4, RETN, APOC3, AGER, NR1I3
12calcitriol45 60 11 2414.0CASR, EPO, TNFRSF11B, ITGAM, NR1I3, IGFBP2
13atp45 2912.0GLO1, RHD, PF4, PTH, ALAD, ITGAM
14steroid4511.0TPMT, RETN, PF4, GLO1, NR1I3, IGFBP2
15lysine4511.0RHD, NR1I3, OXA1L, PF4, AOC3, TNFRSF11B
16testosterone45 60 11 2414.0APOC3, PTH, RETN, ALAD, TNFRSF11B, EPO
17serine4511.0AMBP, CASR, RHD, AGER, NR1I3, ITGAM
18cyclosporin a45 29 6013.0TPMT, EPO, NR1I3, ITGAM, TNFRSF11B, CASR
19cysteine4511.0CASR, AMBP, RETN, TNFRSF11B, ITGAM, OXA1L
20p0024511.0TNFRSF11B, RETN, PF4, IGFBP2, ITGAM, APOC3
21thymidine45 2412.0IGFBP2, PTH, PF4, NR1I3, EPO, MEN1
22malondialdehyde4511.0PF4, ALAD, AOC3, AGER, EPO
23sodium45 2412.0NR1I3, AMBP, CASR, PTH, RETN, TNFRSF11B
24ethanol45 50 11 2413.9RHD, ALAD, ITGAM, NR1I3, AHSG, PF4
25estradiol45 11 2412.9ALAD, NR1I3
26superoxide45 2411.9PF4, ALAD, GLO1, ITGAM
27estrogen4510.9APOC3, AHSG
28urea45 11 2412.9RETN, AMBP, TNFRSF11B, GLO1, EPO
29phosphorus4510.9PTH, CASR, TNFRSF11B, NR1I3
30thyroxine45 2411.9TNFRSF11B, PTH, OXA1L, IGFBP2, RETN
31hydroxyproline45 11 2412.9AOC3, TNFRSF11B, PTH, AHSG
32hydroxyapatite4510.9TNFRSF11B, CASR, AMBP, AHSG
33lactate4510.9GLO1, ITGAM, PF4, EPO, AMBP, ALAD
34forskolin45 50 1112.8IGFBP2, RETN, PTH
35dhea4510.8NR1I3, RETN, IGFBP2, TNFRSF11B
36polyacrylamide4510.8RHD, GLO1, AHSG, AMBP, APOC3
37pamidronate45 50 1112.8PTH, CASR, TNFRSF11B
38aprotinin45 1111.8AMBP, EPO, PF4, PTH
39xbai4510.8AHSG, CASR, APOC3
40alanine4510.8CASR, NR1I3, TPMT, AMBP, PF4, RETN
41heparin45 29 11 2413.8ITGAM, PF4, AGER, APOC3, TNFRSF11B
42uric acid45 2411.7ALAD
43aminoguanidine45 29 1112.7EPO, AOC3, OXA1L
44adenylate4510.7RHD, PF4, GLO1, PTH, CASR, ITGAM
45latex4510.7RHD, ITGAM, AMBP, PF4
46sodium dodecylsulfate4510.6AMBP, OXA1L, IGFBP2, RHD
471,25 dihydroxy vitamin d34510.6NR1I3, PTH, CASR, TNFRSF11B
48homocysteine45 2411.5RHD, APOC3, TNFRSF11B, RETN
49l-tryptophan45 29 11 2413.4CASR, NR1I3, OXA1L
50cuprophan4510.2PF4, EPO, ITGAM

GO Terms for genes affiliated with Uremia

Sources:
16Gene Ontology
See all sources

Cellular components related to Uremia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.6AMBP, TNFRSF11B, APOC3, AGER, IGFBP2, EPO
2extracellular spaceGO:00561510.3AMBP, TNFRSF11B, APOC3, IGFBP2, EPO, AHSG

Biological processes related to Uremia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to nutrientGO:00758410.5IGFBP2, APOC3, TNFRSF11B

Molecular functions related to Uremia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00517910.5PTH, RETN, EPO

Products for genes affiliated with Uremia

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Uremia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet