MCID: URM002
MIFTS: 56

Uremia malady

Nephrological diseases category
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Summaries for Uremia

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65Wikipedia, 33MalaCards
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Wikipedia:65 Uremia or uraemia (see spelling differences) can be translated as \"urea in the blood\". Urea is one of... more...

MalaCards: Uremia, also known as uremia of renal origin, is related to atherosclerosis and hyperparathyroidism. An important gene associated with Uremia is EPO (erythropoietin), and among its related pathways are Transcription Role of VDR in regulation of genes involved in osteoporosis and Osteoblast Signaling. The drugs activated charcoal and charcoal and the compounds phenylhydrazine and saci have been mentioned in the context of this disorder. Affiliated tissues include kidney, testes and endothelial, and related mouse phenotypes are liver/biliary system and cellular.

Aliases & Classifications for Uremia

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8Disease Ontology, 45Novoseek, 62UMLS, 58SNOMED-CT, 35MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological diseases


Aliases & Descriptions:

uremia 8 45 62
uremia of renal origin 8
uremia nos 8


External Ids:

Disease Ontology8 DOID:4676
MeSH35 D014511

Related Diseases for Uremia

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17GeneCards, 18GeneDecks
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Diseases related to Uremia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 149)
idRelated DiseaseScoreTop Affiliating Genes
1atherosclerosis30.6AHSG, TNFRSF11B, APOC3, RETN, CASR
2hyperparathyroidism30.6TNFRSF11B, PTH, EPO, MEN1, CASR, NR1I3
3insulin resistance30.5AHSG, APOC3, RETN
4renal osteodystrophy30.3CASR, PTH, TNFRSF11B
5hyperphosphatemia30.3AHSG, TNFRSF11B, PTH, CASR
6osteomalacia30.0TNFRSF11B, PTH, CASR
7hemolytic anemia29.9RHD, EPO
8osteosclerosis29.9PTH, TNFRSF11B
9rickets29.9PTH, CASR
10acromegaly29.9RETN, MEN1
11diabetes mellitus29.9RHD, CASR, RETN, APOC3, PTH, AHSG
12liver cirrhosis29.8TNFRSF11B, RETN, RHD
13coronary artery disease29.8TNFRSF11B, APOC3, RETN
14obesity29.8AHSG, APOC3, RETN, NR1I3
15primary hyperparathyroidism29.8PTH, MEN1, CASR, NR1I3
16adenoma29.7NR1I3, CASR, MEN1, PTH
17hypertension10.4
18endotheliitis10.4
19hepatitis10.4
20peritonitis10.3
21anuria10.3
22hyperhomocysteinemia10.3
23metabolic acidosis10.2
24kidney disease10.2
25nephrosclerosis10.1
26arteriosclerosis10.1
27malignant hypertension10.1
28vitiligo mental retardation facial dysmorphism uremia10.1
29autonomic dysfunction10.1
30rh isoimmunization10.1RHD, EPO
31neonatal jaundice10.1RHD, NR1I3
32multiple endocrine neoplasia type 2a10.1MEN1, PTH
33myelofibrosis10.1AHSG, EPO
34sickle cell disease10.1RHD, EPO
35malaria10.1RHD, ALAD
36osteoporosis, postmenopausal10.1PTH, TNFRSF11B
37ankylosing spondylitis10.1TNFRSF11B, PTH
38pancytopenia10.1EPO, TPMT
39beta thalassemia10.0TNFRSF11B, EPO, RHD
40osteitis fibrosa10.0CASR, PTH
41lipodystrophy10.0RETN, APOC3
42hyperparathyroidism, neonatal10.0NR1I3, CASR
43calcinosis10.0CASR, PTH
44hyperparathyroidism-jaw tumor syndrome10.0MEN1, CASR
45diabetic nephropathy10.0
46cardiac tamponade10.0
47hepatic coma10.0
48nephronophthisis10.0
49bronchopneumonia10.0
50arthritis10.0

Graphical network of the top 20 diseases related to Uremia:



Diseases related to uremia

Symptoms for Uremia

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Drugs & Therapeutics for Uremia

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Uremia

Search NIH Clinical Center for Uremia

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Uremia

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Anatomical Context for Uremia

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33MalaCards
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MalaCards organs/tissues related to Uremia:

33
Kidney, Testes, Endothelial, Bone, Brain, Heart, Monocytes, Skeletal muscle, Lung, Pancreas, B cells, Smooth muscle, Liver, T cells, Cervix, Bone marrow, Adipocyte, Colon, Small intestine, Pancreatic islet

Animal Models for Uremia or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Uremia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053709.0NR1I3, MEN1, RETN, EPO
2MP:00053847.4TNFRSF11B, APOC3, EPO, MEN1, CASR, NR1I3
3MP:00053977.2TNFRSF11B, PTH, APOC3, TPMT, EPO, CASR
4MP:00107687.1TNFRSF11B, PTH, TPMT, EPO, MEN1, CASR
5MP:00053786.8AHSG, TNFRSF11B, PTH, APOC3, TPMT, MEN1
6MP:00053766.3RHD, AHSG, PTH, APOC3, TPMT, EPO

Publications for Uremia

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52PubMed
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Articles related to Uremia:

(show top 50)    (show all 589)
idTitleAuthorsYear
1
Acute uremia suppresses leucine-induced signal transduction in skeletal muscle. (23783244)
2013
2
Indoxyl sulfate signals for rapid mRNA stabilization of Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 2 (CITED2) and suppresses the expression of hypoxia-inducible genes in experimental CKD and uremia. (23792300)
2013
3
Effects of chronic kidney disease and uremia on hepatic drug metabolism and transport. (24132209)
2013
4
Ghrelin and muscle metabolism in chronic uremia. (22200437)
2012
5
Simultaneous pancreas-kidney transplants are appropriate in insulin-treated candidates with uremia regardless of diabetes type. (21527647)
2011
6
Treatment of cardiovascular calcification in uremia. (21824104)
2011
7
Sex differences in kidney size and clinical features of patients with uremia. (21056871)
2010
8
Ultrastructural analysis of vascular calcifications in uremia. (20203159)
2010
9
ACE inhibition attenuates uremia-induced aortic valve thickening in a novel mouse model. (19257900)
2009
10
C-reactive protein and uremia. (19708997)
2009
11
Severe hemolytic uremia syndrome and antiphospholipid antibodies following bowel infection in the absence of major vascular occlusions: an example of MAPS? (19160952)
2008
12
Uremia-related vascular calcification: more than apatite deposition. (17149373)
2007
13
Brain dysfunction in uremia: a question of cortical hyperexcitability? (15908270)
2005
14
Oxidative stress and uremia. (15660443)
2005
15
IL-10, IL-6, and TNF-alpha: central factors in the altered cytokine network of uremia--the good, the bad, and the ugly. (15780075)
2005
16
Mechanisms of vascular calcification in uremia. (15490398)
2004
17
Monocyte apoptosis in uremia is normalized with continuous blood purification modalities. (14732806)
2004
18
Eating behavior disorders in uremia: a question of balance in appetite regulation. (14717811)
2004
19
Acute uremia produced in rats by nephrotoxic chemicals is alleviated by protein deficient diet. (12911155)
2003
20
Renin-angiotensin gene polymorphism in children with uremia and essential hypertension. (12579405)
2003
21
Efficacy of 19-Nor-1,25-(OH)2D2 in the prevention and treatment of hyperparathyroid bone disease in experimental uremia. (12753289)
2003
22
Homocysteine in uremia. (12612968)
2003
23
Chronic uremia induces permeability changes, increased nitric oxide synthase expression, and structural modifications in the peritoneum. (11562414)
2001
24
MAPnckeberg's medial sclerosis and inorganic phosphate in uremia. (11576921)
2001
25
Coronary artery disease in uremia: Etiology, diagnosis, and therapy. (11737581)
2001
26
Selection bias impacts outcome reports of uremia therapy. (10873894)
2000
27
B lymphopenia in uremia is related to an accelerated in vitro apoptosis and dysregulation of Bcl-2. (10727545)
2000
28
Serum lipids status in patients with diabetic uremia on 10 years of maintenance hemodialysis. (10412780)
1999
29
Introduction to renal osteodystrophy: calcium metabolism in health and uremia. (10372833)
1999
30
Alterations in nonenzymatic biochemistry in uremia: origin and significance of "carbonyl stress" in long-term uremic complications. (9987064)
1999
31
Medical management of secondary hyperparathyroidism in uremia. (10372838)
1999
32
Modulation of parathyroid cell function by calcium ion in health and uremia. (10372834)
1999
33
Acute movement disorders with bilateral basal ganglia lesions in uremia. (9827621)
1998
34
Imidazolium crosslinks derived from reaction of lysine with glyoxal and methylglyoxal are increased in serum proteins of uremic patients: evidence for increased oxidative stress in uremia. (9637262)
1998
35
Effects of benazepril on insulin resistance and glucose tolerance in uremia. (9725782)
1998
36
Effect of metabolic acidosis on insulin action and secretion in uremia. (9690228)
1998
37
The use of the artificial kidney in the treatment of uremia. 1952. (9854252)
1998
38
Use of recombinant human erythropoietin outside the setting of uremia. (9192747)
1997
39
The parathyroid-bone axis in uremia: new insights into old questions. (9051353)
1997
40
Effects of uremic toxins and fatty acids on serum protein binding of furosemide: possible mechanism of the binding defect in uremia. (9439444)
1997
41
Enrollment parathyroid hormone level is a new marker of survival in hemodialysis and peritoneal dialysis therapy for uremia. (8957048)
1996
42
Dysfunction of polymorphonuclear leukocytes in uremia. (8734462)
1996
43
Reactivity to hepatitis B vaccination (HBV) in patients with uremia: association with defined HLA antigen configuration and complement protein allotypes C4A, C4B and B factor (Bf)]. (8834646)
1995
44
The rate and control of baseline red cell production in hematologically stable patients with uremia. (7665976)
1995
45
Reduced production, absorption, and elimination of erythropoietin in uremia compared with healthy volunteers. (7993997)
1994
46
Myocardial texture and cardiac calcification in uremia. (8345830)
1993
47
Growth hormone metabolism in uremia. (1777890)
1991
48
Progression to uremia after remission of acute poststreptococcal glomerulonephritis. (787789)
1976
49
The influence of uremia upon renal hypertension. (5438011)
1970
50
Uremia and disseminated platelet-cell (thrombocyte) thrombosis; report of a case due to malignant nephrosclerosis with acute pancreatitis. (14914218)
1952

Variations for Uremia

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Expression for genes affiliated with Uremia

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Uremia

Search GEO for disease gene expression data for Uremia.

Pathways for genes affiliated with Uremia

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50PathCards, 60Thomson Reuters, 38NCBI BioSystems Database
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Pathways related to Uremia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7PTH, TNFRSF11B
29.7PTH, TNFRSF11B

Compounds for genes affiliated with Uremia

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45Novoseek, 24HMDB, 11DrugBank, 29IUPHAR, 51PharmGKB, 3BitterDB, 61Tocris Bioscience
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Compounds related to Uremia according to GeneCards/GeneDecks:

(show top 50)    (show all 71)
idCompoundScoreTop Affiliating Genes
1phenylhydrazine4510.3EPO, RHD
2saci4510.1AHSG, APOC3
3succinylacetone4510.0ALAD, EPO
4zinc protoporphyrin459.9EPO, ALAD
5hydroxyproline45 24 1111.7PTH, TNFRSF11B, AHSG
6gadolinium459.6CASR, NR1I3
7cinacalcet45 29 1111.6CASR, NR1I3
8strontium459.5TNFRSF11B, CASR
9protoporphyrin ix45 24 1111.5ALAD, EPO
10ethanol45 51 24 1112.5RHD, NR1I3, ALAD, AHSG
11dhea459.4TNFRSF11B, RETN, NR1I3
12thymidine45 2410.4PTH, EPO, MEN1, NR1I3
13neomycin459.4EPO, CASR, NR1I3
14azathioprine45 3 51 1112.4EPO, TPMT, TNFRSF11B
15urea45 24 1111.3TNFRSF11B, EPO, RETN
16xbai459.3CASR, APOC3, AHSG
17pamidronate45 51 1111.3CASR, PTH, TNFRSF11B
1825-hydroxyvitamin d459.2CASR, PTH, TNFRSF11B
19iron45 2410.2RHD, ALAD, EPO, TNFRSF11B
20p002459.2TNFRSF11B, APOC3, RETN
21atorvastatin45 51 29 24 1113.2RETN, APOC3, TNFRSF11B
22hydroxyapatite459.2CASR, TNFRSF11B, AHSG
23thyroxine45 2410.2RETN, PTH, TNFRSF11B
24homocysteine45 2410.1RHD, RETN, APOC3, TNFRSF11B
25fibrinogen459.0AHSG, TNFRSF11B, APOC3, RETN
26aspartate459.0RHD, RETN, EPO, TNFRSF11B
27phosphorus458.9TNFRSF11B, PTH, CASR, NR1I3
281,25 dihydroxy vitamin d3458.9TNFRSF11B, PTH, CASR, NR1I3
29inositol 1,4,5 trisphosphate458.9PTH, CASR, NR1I3
30vegf458.8MEN1, RETN, EPO, PTH, TNFRSF11B
31estradiol45 24 1110.8TNFRSF11B, PTH, RETN, ALAD, NR1I3
32calcitriol45 61 24 1111.7TNFRSF11B, PTH, EPO, CASR, NR1I3
33cholesterol45 29 24 1111.6NR1I3, RETN, APOC3, TNFRSF11B
34forskolin45 51 1110.6TNFRSF11B, PTH, RETN, CASR
35magnesium45 24 1110.5TNFRSF11B, PTH, CASR, ALAD, NR1I3
36lysine458.5RHD, NR1I3, ALAD, CASR, TNFRSF11B
37sodium45 249.4TNFRSF11B, PTH, RETN, CASR, NR1I3
38steroid458.4TNFRSF11B, APOC3, TPMT, RETN, NR1I3
39lipid458.3TNFRSF11B, APOC3, RETN, ALAD, NR1I3, RHD
40cyclosporin a45 29 6110.3TNFRSF11B, TPMT, EPO, CASR, NR1I3
41atp45 299.3TNFRSF11B, PTH, APOC3, TPMT, ALAD, RHD
42testosterone45 61 24 1111.1TNFRSF11B, PTH, APOC3, EPO, RETN, ALAD
43serine458.0TNFRSF11B, APOC3, MEN1, CASR, NR1I3, RHD
44nitric oxide45 24 119.9TNFRSF11B, PTH, APOC3, RETN, CASR, ALAD
45glucose457.7AHSG, TNFRSF11B, PTH, APOC3, RETN, CASR
46vitamin d457.6AHSG, TNFRSF11B, PTH, EPO, MEN1, CASR
47estrogen457.3AHSG, TNFRSF11B, PTH, APOC3, RETN, MEN1
48creatinine457.0TNFRSF11B, PTH, APOC3, TPMT, EPO, RETN
49calcium45 51 24 1110.0AHSG, TNFRSF11B, PTH, RETN, MEN1, CASR
50tyrosine455.7RHD, AHSG, TNFRSF11B, PTH, APOC3, TPMT

GO Terms for genes affiliated with Uremia

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16Gene Ontology
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Cellular components related to Uremia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.6EPO, APOC3, PTH, TNFRSF11B, AHSG
2extracellular spaceGO:0056157.8RETN, AHSG, TNFRSF11B, PTH, APOC3, EPO

Biological processes related to Uremia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to estrogenGO:0436279.7EPO, TNFRSF11B
2response to testosteroneGO:0335749.6EPO, TPMT
3skeletal system developmentGO:0015019.4PTH, TNFRSF11B, AHSG
4response to drugGO:0424939.1TNFRSF11B, PTH, APOC3
5G-protein coupled receptor signaling pathwayGO:0071868.6CASR, APOC3, PTH

Molecular functions related to Uremia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.4RETN, EPO, PTH

Products for genes affiliated with Uremia

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  • Antibodies
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Sources for Uremia

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet