MCID: URM005
MIFTS: 39

Uremic Pruritus malady

Categories: Rare diseases

Aliases & Classifications for Uremic Pruritus

Aliases & Descriptions for Uremic Pruritus:

Name: Uremic Pruritus 56 69

Characteristics:

Orphanet epidemiological data:

56
uremic pruritus
Prevalence: 1-5/10000 (Europe);

Classifications:



External Ids:

Orphanet 56 ORPHA94059
UMLS via Orphanet 70 C1262019

Summaries for Uremic Pruritus

MalaCards based summary : Uremic Pruritus is related to tau syndrome and egg allergy. An important gene associated with Uremic Pruritus is IL18 (Interleukin 18), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Influenza A. The drugs Gabapentin and Fexofenadine have been mentioned in the context of this disorder. Affiliated tissues include kidney, skin and lymph node, and related phenotypes are digestive/alimentary and homeostasis/metabolism

Wikipedia : 71 Uremic pruritus (also known as uraemic pruritus or renal pruritus) is caused by chronic kidney failure... more...

Related Diseases for Uremic Pruritus

Diseases related to Uremic Pruritus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 123)
id Related Disease Score Top Affiliating Genes
1 tau syndrome 10.3 IL18 IL1B
2 egg allergy 10.3 IL18 IL1B
3 retinal cancer 10.2 CRP IL1B
4 cataract 10.2 CRP IL1B
5 familial hyperthyroidism due to mutations in tsh receptor 10.2 IL18 IL1B
6 oculomotor nerve paralysis 10.2 IL1B IL6
7 common peroneal nerve lesion 10.2 IL1B IL6
8 cerebrum cancer 10.2 CRP IL1B
9 adenylosuccinase lyase deficiency 10.2 IL18 IL2
10 coloboma of iris 10.2 CRP IL6
11 childhood electroclinical syndrome 10.2 IL1B IL6
12 anal paget's disease 10.2 IL1B IL6
13 glucosephosphate dehydrogenase deficiency 10.2 IL1B IL6
14 cutaneous sclerosis 10.2 CRP IL6
15 amyotrophic lateral sclerosis type 14 10.2 IL1B IL2
16 shoulder impingement syndrome 10.2 CRP IL6
17 unilateral multicystic dysplastic kidney 10.2 CRP IL6
18 bipolar i disorder 10.2 IL1B IL6
19 neutrophilia, hereditary 10.2 CRP IL6
20 swine influenza 10.2 CRP IL6
21 cardiac tuberculosis 10.2 CRP IL6
22 thymic neuroendocrine carcinoma 10.1 IL2 IL6
23 cataract, total congenital 10.1 CRP IL6
24 acute allergic sanguinous otitis media 10.1 IL2 IL6
25 gastric lymphoma 10.1 CRP IL6
26 measles 10.1 IL1B IL6
27 secretory diarrhea myopathy and deafness 10.1 CRP IL6
28 hemangioma of spleen 10.1 CRP IL6
29 mixed eosinophil-basophil adenoma 10.1 CRP IL6
30 dextrocardia 10.1 IL1B IL6
31 labyrinthine bilateral reactive loss 10.1 IL2 IL6
32 bullous retinoschisis 10.1 IL1B IL6
33 cinca syndrome 10.1 CRP IL1B
34 retinal degeneration 10.1 CRP IL6
35 clostridium difficile colitis 10.1 IL2 IL6
36 steroid dehydrogenase deficiency dental anomalies 10.1 IL18 IL1B IL6
37 gastric leiomyoma 10.1 IL18 IL1B IL6
38 carbuncle 10.1 IL1B IL6
39 acquired thrombocytopenia 10.1 IL18 IL1B IL6
40 wilkes stevenson syndrome 10.1 CRP IL1B IL2
41 rosacea 10.1 IL1B SLC17A5
42 hypoparathyroidism-retardation-dysmorphism syndrome 10.1 IL1B IL6
43 allergic bronchopulmonary aspergillosis 10.1 CRP IL18 IL6
44 human immunodeficiency virus infectious disease 10.1 CRP IL1B IL6
45 cyclosporiasis 10.1 IL2 IL6
46 neuropathy 10.1 CRP IL1B IL6
47 mental retardation, autosomal dominant 22 10.1 IL18 IL1B
48 pancreas lymphoma 10.1 CRP IL1B IL6
49 atrophy of prostate 10.1 CRP IL1B IL6
50 blepharochalasis 10.1 CRP IL1B IL6

Graphical network of the top 20 diseases related to Uremic Pruritus:



Diseases related to Uremic Pruritus

Symptoms & Phenotypes for Uremic Pruritus

MGI Mouse Phenotypes related to Uremic Pruritus:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.35 IL2 IL6 OPRK1 CNR1 IL18
2 homeostasis/metabolism MP:0005376 9.23 IL1B IL2 IL6 OPRK1 SLC17A5 CNR1

Drugs & Therapeutics for Uremic Pruritus

Drugs for Uremic Pruritus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 78)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
2
Fexofenadine Approved Phase 4 83799-24-0 3348
3
Histamine Approved, Investigational Phase 4 75614-87-8, 51-45-6 774
4
Pregabalin Approved, Illicit, Investigational Phase 4 148553-50-8 5486971
5
Ethanol Approved Phase 4 64-17-5 702
6
Glycerol Approved, Experimental Phase 4 56-81-5 753
7
Benzyl alcohol Approved Phase 4 100-51-6 244
8
Petrolatum Approved Phase 4 8009-03-8
9
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4 59-02-9 14985
10
Histamine Phosphate Phase 4 51-74-1 65513
11 Analgesics Phase 4,Phase 2,Phase 3,Phase 1
12 calcium channel blockers Phase 4
13 Neurotransmitter Agents Phase 4
14 Histamine Antagonists Phase 4
15 Histamine H1 Antagonists Phase 4
16 Histamine H1 Antagonists, Non-Sedating Phase 4
17 Tranquilizing Agents Phase 4
18 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1
19 Emollients Phase 4,Phase 3
20 Anti-Allergic Agents Phase 4
21 Anti-Anxiety Agents Phase 4
22 Anticonvulsants Phase 4
23 Psychotropic Drugs Phase 4
24 Calcium, Dietary Phase 4
25 Central Nervous System Depressants Phase 4,Phase 2,Phase 3,Phase 1
26 Tocopherols Phase 4
27 Dermatologic Agents Phase 4,Phase 3
28 Anesthetics Phase 4
29 Anesthetics, Local Phase 4
30 Vasodilator Agents Phase 4
31 Polymethyl Methacrylate Phase 4
32 Pramoxine Phase 4
33 Protective Agents Phase 4
34 Carbopol 940 Phase 4
35 Citrate Nutraceutical Phase 4
36
Citric Acid Nutraceutical, Vet_approved Phase 4 77-92-9 311
37 Tocopherol Nutraceutical Phase 4
38
Nalbuphine Approved Phase 2, Phase 3, Phase 1 20594-83-6 5360630 5311304
39
Diphenhydramine Approved Phase 2, Phase 3 58-73-1, 147-24-0 3100
40
Promethazine Approved Phase 2, Phase 3 60-87-7 4927
41 Narcotic Antagonists Phase 2, Phase 3, Phase 1
42 Narcotics Phase 2, Phase 3, Phase 1
43 Analgesics, Opioid Phase 2, Phase 3, Phase 1
44 Antipruritics Phase 2, Phase 3
45 Cromolyn Sodium Phase 2
46 Anti-Asthmatic Agents Phase 2
47 Respiratory System Agents Phase 2
48 Olive Nutraceutical Phase 1, Phase 2
49 Omega 3 Fatty Acid Nutraceutical Phase 1, Phase 2
50 Fumitory Nutraceutical Phase 2

Interventional clinical trials:

(show all 28)
id Name Status NCT ID Phase
1 Efficacy of Pregabalin in the Management of Chronic Uremic Pruritus Unknown status NCT01073501 Phase 4
2 Pregabalin for the Treatment of Uremic Pruritus Unknown status NCT01852318 Phase 4
3 Uremic Pruritus, Cytokines and Polymethylmethacrylate Artificial Kidney Completed NCT00442819 Phase 4
4 Comparative Study of the Efficacy of SARNA Sensitive Lotion for Treatment of Uremic Itch in Adult Hemodialysis Patients Completed NCT00693654 Phase 4
5 A Randomized-Withdrawal Phase 3 Study Evaluating the Safety and Efficacy of Oral Nalfurafine HCl (AC-820)in Subjects on Hemodialysis With Uremic Pruritus (Renal Itch) Unknown status NCT00793156 Phase 3
6 Study of Nalbuphine HCl ER Tablets in Hemodialysis Patients With Uremic Pruritus Completed NCT02143648 Phase 2, Phase 3
7 Open Label Extension Study of Nalbuphine HCl ER in Hemodialysis Patients With Uremic Pruritus Completed NCT02143973 Phase 2, Phase 3
8 Efficacy, Local Tolerance and Patient Acceptability of a Moisturizing Emollient in Patients With Uremic Xerosis Completed NCT01084720 Phase 3
9 Study to Evaluate IV CR845 in Hemodialysis Patients With Moderate-to-Severe Pruritus Recruiting NCT02858726 Phase 2, Phase 3
10 Combined Western and Traditional Chinese Medicine Daycare for CKD Patients Recruiting NCT02545036 Phase 3
11 Treatment of Uremic Pruritus by Olive-omega 3 Ointment Unknown status NCT01447693 Phase 1, Phase 2
12 Treatment of Uremic Pruritus With PA101B Completed NCT02696499 Phase 2
13 Safety and Pharmacokinetics of IV CR845 in Hemodialysis Patients, and Its Efficacy in Patients With Uremic Pruritus Completed NCT02229929 Phase 2
14 Evaluating the Effect of Cromolyn Sodium in Uremic Pruritus Completed NCT00745199 Phase 2
15 Evaluating the Effect of Fumaria Parviflora L. in Uremic Pruritus Completed NCT02671162 Phase 2
16 Efficacy and Safety of MT-9938 for Treatment of Uremic Pruritus in Subjects With End-stage Renal Disease Receiving Hemodialysis Terminated NCT01660243 Phase 2
17 Phase 1 Study of Nalbuphine HCl ER Tablets in Hemodialysis Patients With Uremic Pruritus Completed NCT02373215 Phase 1
18 TRK-820 Study in Subjects on Hemodialysis With or Without Uremic Pruritus Active, not recruiting NCT03002233 Phase 1
19 Efficacy of Calmmax Cream in the Management of Chronic Uremic Pruritus Unknown status NCT02032537
20 Gabapentin - A Solution to Uremic Pruritus? Unknown status NCT00577967
21 An Observational Study of Pruritus Amongst Hemodialysis Patients Unknown status NCT00715260
22 Efficacy of Laser Acupuncture on Pruritus in Patients With Chronic Kidney Disease Undergoing Hemodialysis Unknown status NCT02432508
23 Small-fiber Neuropathy in Chronic Kidney Disease Unknown status NCT01078857
24 Evaluating the Effect of Senna in Uremic Pruritus Completed NCT02008864
25 Montelukast for Treatment of Uremic Pruritus Completed NCT02559388
26 The Effect of Phototherapy on Pruritus of Patients With Chronic Kidney Disease Completed NCT00494975
27 Pruritus in Patients With Chronic Kidney Disease Completed NCT01727180
28 Gabapentin for Prophylaxis Intrathecal Morphine-Induced Pruritus Completed NCT01236859

Search NIH Clinical Center for Uremic Pruritus

Genetic Tests for Uremic Pruritus

Anatomical Context for Uremic Pruritus

MalaCards organs/tissues related to Uremic Pruritus:

39
Kidney, Skin, Lymph Node

Publications for Uremic Pruritus

Articles related to Uremic Pruritus:

(show top 50) (show all 126)
id Title Authors Year
1
Sleep Disorders, Restless Legs Syndrome, and Uremic Pruritus: Diagnosis and Treatment of Common Symptoms in DialysisA Patients. ( 27693261 )
2017
2
Acupressure and Transcutaneous Electrical Acupoint Stimulation for Improving Uremic Pruritus: A Randomized, Controlled Trial. ( 27228268 )
2016
3
Comparison of Gabapentin and Ketotifen in Treatment of Uremic Pruritus in Hemodialysis Patients. ( 27022338 )
2016
4
Uremic Pruritus Is Not Associated with Endocannabinoid Receptor 1 Gene Polymorphisms. ( 27034934 )
2016
5
Uremic pruritus treated successfully with the Goeckerman Program. ( 27617950 )
2016
6
An Observational Longitudinal Study Investigating the Effectiveness of 75a88mg Pregabalin Post-Hemodialysis among Uremic Pruritus Patients. ( 27824127 )
2016
7
Comparison of uremic pruritus between patients undergoing hemodialysis and peritoneal dialysis. ( 27366666 )
2016
8
Environmental NO2 and CO Exposure: Ignored Factors Associated with Uremic Pruritus in Patients Undergoing Hemodialysis. ( 27507591 )
2016
9
Gabapentin: A promising therapy for uremic pruritus in hemodialysis patients: A randomized-controlled trial and review of literature. ( 27043168 )
2016
10
Development of a Multidimensional Assessment Tool for Uremic Pruritus in Dialysis Patients (UP-Dial). ( 28012182 )
2016
11
Gabapentin for uremic pruritus in hemodialysis patients: a qualitative systematic review. ( 27022475 )
2016
12
A Comparison of Uremic Pruritus in Patients Receiving Peritoneal Dialysis and Hemodialysis. ( 26945400 )
2016
13
Comparison of pregabalin with doxepin in the management of uremic pruritus: a randomized single blind clinical trial. ( 27397522 )
2016
14
Loss of Papillary Dermal Calcitonin Gene Related Peptide-Expressing Neurons Significantly Correlates with Uremic Pruritus. ( 27448750 )
2016
15
Reply to: Gabapentin: A promising therapy for uremic pruritus in hemodialysis patients: A randomized-controlled trial and review of literature. ( 27687138 )
2016
16
Effect of Auricular Acupressure on Uremic Pruritus in Patients Receiving Hemodialysis Treatment: A Randomized Controlled Trial. ( 26495017 )
2015
17
Is uremic pruritus still an important clinical problem in maintenance hemodialysis patients? ( 26616469 )
2015
18
Role of Interleukin-2 in Uremic Pruritus Among Attendants of AL-Zahraa Hospital Dialysis Unit. ( 25814728 )
2015
19
Association of high-sensitive C-reactive protein and dialysis adequacy with uremic pruritus. ( 26354559 )
2015
20
Comparison of Avena sativa, vinegar, and hydroxyzine for uremic pruritus of hemodialysis patients: a crossover randomized clinical trial. ( 26174460 )
2015
21
Safety of pregabalin among hemodialysis patients suffering from uremic pruritus. ( 26702255 )
2015
22
Uremic pruritus is improved by gabapentin. ( 24898738 )
2014
23
Effects of turmeric on uremic pruritus in end stage renal disease patients: a double-blind randomized clinical trial. ( 24482090 )
2014
24
Uremic pruritus pathogenesis, revisited. ( 25366503 )
2014
25
Efficacy and Safety of Gabapentin for Uremic Pruritus and Restless Legs Syndrome in Conservatively Managed Patients With Chronic Kidney Disease. ( 25220049 )
2014
26
Uremic pruritus. ( 24402092 )
2014
27
Quiz page August 2014: pruritus in a dialysis patient. Mycosis fungoides (folliculotropic variant) in a dialysis patient, with rare presentation of persistent generalized pruritus with characteristics of uremic pruritus without skin lesions. ( 25060007 )
2014
28
Interleukin-31 is associated with uremic pruritus in patients receiving hemodialysis. ( 25270263 )
2014
29
The effect of ergocalciferol on uremic pruritus severity: a randomized controlled trial. ( 23453391 )
2013
30
Effect of acupressure on patients in Turkey receiving hemodialysis treatment for uremic pruritus. ( 23981400 )
2013
31
Longitudinal predictors of uremic pruritus. ( 24209894 )
2013
32
Uremic pruritus and serum phosphorus level. ( 23945893 )
2013
33
Use of sertraline for antihistamine-refractory uremic pruritus in renal palliative care patients. ( 23777329 )
2013
34
Use of pregabalin in the management of chronic uremic pruritus. ( 22819436 )
2013
35
Uremic pruritus, dialysis adequacy, and metabolic profiles in hemodialysis patients: a prospective 5-year cohort study. ( 23940749 )
2013
36
Therapeutic effect of oral nicotinamide on refractory uremic pruritus: a randomized, double-blind study. ( 24029269 )
2013
37
Effective treatment of uremic pruritus and acquired perforating dermatosis with amitriptyline. ( 23425115 )
2013
38
Uremic pruritus. ( 21983988 )
2012
39
Efficacy of omega-3 fatty acids supplementation in treatment of uremic pruritus in hemodialysis patients: a double-blind randomized controlled trial. ( 23115713 )
2012
40
HbA1c is related with uremic pruritus in diabetic and nondiabetic hemodialysis patients. ( 21370992 )
2012
41
Uremic pruritus in hemodialysis patients: treatment with desloratidine versus gabapentin. ( 22850916 )
2012
42
Effect of sertraline on uremic pruritus improvement in ESRD patients. ( 22973512 )
2012
43
Baby oil therapy for uremic pruritus in haemodialysis patients. ( 22093006 )
2012
44
The role of ondansetron in the management of cholestatic or uremic pruritus--a systematic review. ( 22727254 )
2012
45
Interleukin-2 serum levels are elevated in patients with uremic pruritus: a novel finding with practical implications. ( 21372257 )
2011
46
A longitudinal study of uremic pruritus in hemodialysis patients. ( 20558560 )
2010
47
Acupuncture for treating uremic pruritus in patients with end-stage renal disease: a systematic review. ( 21796811 )
2010
48
Elevated C-reactive protein level in hemodialysis patients with moderate/severe uremic pruritus: a potential mediator of high overall mortality. ( 20350963 )
2010
49
Topical capsaicin therapy for uremic pruritus in patients on hemodialysis. ( 20404425 )
2010
50
Gabapentin and uremic pruritus in hemodialysis patients. ( 19212903 )
2009

Variations for Uremic Pruritus

Expression for Uremic Pruritus

Search GEO for disease gene expression data for Uremic Pruritus.

Pathways for Uremic Pruritus

Pathways related to Uremic Pruritus according to GeneCards Suite gene sharing:

(show all 32)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.15 IL18 IL1B IL2 IL31 IL6
2
Show member pathways
12.6 IL18 IL1B IL2 IL6
3
Show member pathways
12.41 IL18 IL1B IL2 IL6
4
Show member pathways
12.4 IL18 IL1B IL2 IL6
5
Show member pathways
12.09 CRP IL1B IL2 IL6
6 12.06 IL18 IL1B IL6
7 11.85 IL1B IL2 IL6
8 11.82 IL18 IL1B IL6
9
Show member pathways
11.81 IL18 IL1B IL2
10 11.69 IL18 IL1B IL6
11 11.66 IL18 IL1B IL6
12 11.62 IL18 IL1B IL2
13 11.57 IL1B IL2 IL6
14
Show member pathways
11.47 IL1B IL2 IL6
15
Show member pathways
11.47 IL18 IL1B IL2 IL6
16 11.39 IL18 IL1B IL6
17 11.3 IL18 IL1B IL6
18 11.27 IL18 IL1B IL6
19 11.2 IL1B IL6
20 11.19 IL1B IL6
21 11.14 IL1B IL6
22 11.08 IL18 IL2
23 11.04 IL18 IL1B IL6
24 11.03 IL18 IL1B
25 10.97 IL18 IL1B
26
Show member pathways
10.95 IL18 IL1B IL2 IL6
27 10.94 IL18 IL1B IL6
28 10.9 CRP IL6
29 10.9 IL18 IL1B IL2 IL6
30 10.81 IL1B IL2 IL6
31 10.78 IL1B IL6
32 10.37 IL18 IL1B

GO Terms for Uremic Pruritus

Cellular components related to Uremic Pruritus according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.43 CRP IL18 IL1B IL2 IL31 IL6
2 extracellular space GO:0005615 9.1 CRP IL18 IL1B IL2 IL31 IL6

Biological processes related to Uremic Pruritus according to GeneCards Suite gene sharing:

(show all 23)
id Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.78 CRP IL18 IL1B IL6
2 response to lipopolysaccharide GO:0032496 9.74 CNR1 IL1B IL6
3 response to ethanol GO:0045471 9.7 CNR1 IL2 OPRK1
4 response to cocaine GO:0042220 9.61 CNR1 OPRK1
5 acute-phase response GO:0006953 9.61 CRP IL6
6 positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 9.6 IL18 IL6
7 lipopolysaccharide-mediated signaling pathway GO:0031663 9.59 IL18 IL1B
8 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.58 IL1B IL2
9 response to morphine GO:0043278 9.58 CNR1 OPRK1
10 positive regulation of activated T cell proliferation GO:0042104 9.56 IL18 IL2
11 natural killer cell activation GO:0030101 9.55 IL18 IL2
12 positive regulation of NF-kappaB import into nucleus GO:0042346 9.54 IL18 IL1B
13 positive regulation of interleukin-17 production GO:0032740 9.51 IL18 IL2
14 positive regulation of T cell proliferation GO:0042102 9.5 IL1B IL2 IL6
15 positive regulation of immunoglobulin secretion GO:0051024 9.49 IL2 IL6
16 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.46 IL18 IL1B
17 negative regulation of lipid storage GO:0010888 9.43 CRP IL6
18 positive regulation of T-helper 2 cell differentiation GO:0045630 9.4 IL18 IL6
19 positive regulation of tissue remodeling GO:0034105 9.37 IL18 IL2
20 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.33 IL18 IL2 IL6
21 positive regulation of fever generation GO:0031622 9.26 CNR1 IL1B
22 positive regulation of interferon-gamma production GO:0032729 9.13 IL18 IL1B IL2
23 immune response GO:0006955 9.02 IL18 IL1B IL2 IL6 OPRK1

Molecular functions related to Uremic Pruritus according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 IL18 IL1B IL2 IL31 IL6

Sources for Uremic Pruritus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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