MCID: URM005
MIFTS: 35

Uremic Pruritus malady

Rare diseases category

Summaries for Uremic Pruritus

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Wikipedia:63 Uremic pruritus (also known as uraemic pruritus or renal pruritus) is caused by chronic kidney failure... more...

MalaCards based summary: Uremic Pruritus is related to kidney disease and blindness. An important gene associated with Uremic Pruritus is OPRK1 (opioid receptor, kappa 1), and among its related pathways are African trypanosomiasis and Malaria. The compounds hydroxide and anakinra have been mentioned in the context of this disorder. Affiliated tissues include kidney, skin and lymph node, and related mouse phenotypes are digestive/alimentary and growth/size/body.

Aliases & Classifications for Uremic Pruritus

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Sources:
47Orphanet, 60UMLS, 61UMLS via Orphanet
See all sources

Uremic Pruritus, Aliases & Descriptions:

Name: Uremic Pruritus 47 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Characteristics (Orphanet epidemiological data):

47
uremic pruritus:
Prevalence: 1-5/10000 (Europe)


External Ids:

Orphanet47 94059
UMLS via Orphanet61 C1262019

Related Diseases for Uremic Pruritus

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Diseases related to Uremic Pruritus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 52)
idRelated DiseaseScoreTop Affiliating Genes
1kidney disease30.1IL6, IL2
2blindness10.5
3scrub typhus10.4SLC17A5
4liver disease10.3IL6
5peritonitis10.3
6capillary leak syndrome10.3IL2
7adult-onset still's disease10.2IL6, IL18
8hepatitis10.1
9mycosis fungoides10.1
10restless legs syndrome10.1
11viral hepatitis10.1
12synovitis10.1IL6, IL18
13hepatitis b10.1IL18, SLC17A5
14galactosemia10.1SLC17A5, IL18
15pneumonia10.1IL6
16periodontitis10.1SLC17A5, IL6
17nutritional deficiency disease10.1SLC17A5, IL6
18alcohol dependence10.1SLC17A5, OPRK1
19lipid metabolism disorder10.1SLC17A5, IL6
20t-cell large granular lymphocyte leukemia10.1IL2, IL18
21colitis10.1IL6, IL18
22pancreatitis10.0SLC17A5, IL6
23acute graft versus host disease10.0IL2, IL18
24pulmonary sarcoidosis10.0IL18, IL2
25pulmonary tuberculosis10.0IL18, IL2
26skin disease10.0IL6, IL2
27acquired immunodeficiency syndrome10.0IL2, IL6
28graft-versus-host disease, protection against10.0IL2, IL18
29connective tissue disease10.0IL2, IL6
30inflammatory bowel disease10.0IL2, IL6
31eosinophilia10.0IL18, IL2
32osteoarthritis10.0OPRK1, IL6, IL18
33coronary artery disease10.0IL18, IL6
34sarcoidosis 19.9IL18, IL2
35acute pancreatitis9.9SLC17A5, IL6, IL18
36periodontal disease9.9SLC17A5, IL6, IL18
37preeclampsia/eclampsia 19.9IL18, IL6, SLC17A5
38diabetes mellitus, noninsulin-dependent9.9SLC17A5, IL6, IL18
39obesity9.9IL18, IL6, SLC17A5
40atopic dermatitis9.9IL18, IL2
41vascular disease9.9IL6, IL2
42lymphopenia9.8IL6, IL18, IL2
43systemic lupus erythematosus9.8IL6, IL18, IL2
44psoriasis9.8IL2, IL18, IL6
45multiple sclerosis, disease progression, modifier of9.8IL6, IL18, IL2
46hypersensitivity reaction type ii disease9.8IL6, IL18, IL2
47leukopenia9.8SLC17A5, IL6, IL2
48hepatitis c9.8IL2, IL18, SLC17A5
49thrombocytopenia9.8IL2, IL6, SLC17A5
50ipex syndrome9.6OPRK1, IL6, IL18, IL2

Graphical network of the top 20 diseases related to Uremic Pruritus:



Diseases related to uremic pruritus

Symptoms for Uremic Pruritus

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Drugs & Therapeutics for Uremic Pruritus

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Drug clinical trials:

Search ClinicalTrials for Uremic Pruritus

Search NIH Clinical Center for Uremic Pruritus

Genetic Tests for Uremic Pruritus

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Anatomical Context for Uremic Pruritus

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MalaCards organs/tissues related to Uremic Pruritus:

31
Kidney, Skin, Lymph node

Animal Models for Uremic Pruritus or affiliated genes

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MGI Mouse Phenotypes related to Uremic Pruritus:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.1IL2, IL18, IL6, OPRK1
2MP:00053788.0SLC17A5, IL6, IL18, IL2
3MP:00053847.7IL2, IL18, IL6, SLC17A5
4MP:00053867.5SLC17A5, OPRK1, IL6, IL18, IL2

Publications for Uremic Pruritus

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Articles related to Uremic Pruritus:

(show top 50)    (show all 106)
idTitleAuthorsYear
1
Role of Interleukin-2 in Uremic Pruritus Among Attendants of AL-Zahraa Hospital Dialysis Unit. (25814728)
2015
2
Quiz page August 2014: pruritus in a dialysis patient. Mycosis fungoides (folliculotropic variant) in a dialysis patient, with rare presentation of persistent generalized pruritus with characteristics of uremic pruritus without skin lesions. (25060007)
2014
3
Efficacy and Safety of Gabapentin for Uremic Pruritus and Restless Legs Syndrome in Conservatively Managed Patients With Chronic Kidney Disease. (25220049)
2014
4
Interleukin-31 is associated with uremic pruritus in patients receiving hemodialysis. (25270263)
2014
5
Uremic pruritus. (24402092)
2014
6
Uremic pruritus pathogenesis, revisited. (25366503)
2014
7
The effect of ergocalciferol on uremic pruritus severity: a randomized controlled trial. (23453391)
2013
8
Uremic pruritus, dialysis adequacy, and metabolic profiles in hemodialysis patients: a prospective 5-year cohort study. (23940749)
2013
9
Longitudinal predictors of uremic pruritus. (24209894)
2013
10
Effective treatment of uremic pruritus and acquired perforating dermatosis with amitriptyline. (23425115)
2013
11
Effect of acupressure on patients in Turkey receiving hemodialysis treatment for uremic pruritus. (23981400)
2013
12
Effect of sertraline on uremic pruritus improvement in ESRD patients. (22973512)
2012
13
Baby oil therapy for uremic pruritus in haemodialysis patients. (22093006)
2012
14
Efficacy of omega-3 fatty acids supplementation in treatment of uremic pruritus in hemodialysis patients: a double-blind randomized controlled trial. (23115713)
2012
15
Uremic pruritus. (21983988)
2012
16
Acupuncture for treating uremic pruritus in patients with end-stage renal disease: a systematic review. (21796811)
2010
17
A longitudinal study of uremic pruritus in hemodialysis patients. (20558560)
2010
18
A pramoxine-based anti-itch lotion is more effective than a control lotion for the treatment of uremic pruritus in adult hemodialysis patients. (18821119)
2009
19
Gabapentin and uremic pruritus in hemodialysis patients. (19212903)
2009
20
Nalfurafine hydrochloride: a new drug for the treatment of uremic pruritus in hemodialysis patients. (19584962)
2009
21
Nicotinamide as a potential novel addition to the anti-uremic pruritus weaponry. (19237824)
2009
22
Characteristics of uremic pruritus in hemodialysis patients: data from a single center. (18794819)
2008
23
Uremic pruritus, cytokines, and polymethylmethacrylate artificial kidney. (18422797)
2008
24
Effect of oral granisetron in uremic pruritus. (17675729)
2007
25
Uremic pruritus. (17429345)
2007
26
Clinical characteristics of uremic pruritus in patients undergoing haemodialysis. (16499798)
2006
27
Therapeutic effect of topical gamma-linolenic acid on refractory uremic pruritus. (16797388)
2006
28
Efficacy and safety of a new kappa-opioid receptor agonist for the treatment of uremic pruritus. (16932462)
2006
29
An epidemiology study of patients with uremic pruritus. (16836494)
2006
30
Etiology and prognostic significance of severe uremic pruritus in chronic hemodialysis patients. (16672924)
2006
31
A comparative study on the effects of naltrexone and loratadine on uremic pruritus. (15178915)
2004
32
Uremic pruritus: still an important clinical problem. (15523377)
2004
33
Uremic pruritus: a clinical study of maintenance hemodialysis patients. (12432992)
2002
34
Management of uremic pruritus. (10833778)
2000
35
Naltrexone does not relieve uremic pruritus: results of a randomized, double-blind, placebo-controlled crossover study. (10703675)
2000
36
Ondansetron therapy for uremic pruritus in hemodialysis patients. (10793015)
2000
37
Uremic pruritus: an unresolved problem in hemodialysis patients. (10224488)
1999
38
Is aluminum toxicity responsible for uremic pruritus in chronic hemodialysis patients? (9031270)
1997
39
Potentially toxic self-treatment of uremic pruritus with topical pyrethroid insecticides. (8997483)
1997
40
Uremic pruritus in CAPD patients. (9358524)
1997
41
L-carnitine does not alleviate uremic pruritus in hemodialysis patients. (9069470)
1997
42
Uremic pruritus. (8791145)
1996
43
Uremic pruritus. (8679435)
1995
44
Uremic pruritus: a review. (1738396)
1992
45
Uremic pruritus in patients on hemodialysis or continuous ambulatory peritoneal dialysis (CAPD). The role of plasma histamine and skin mast cells. (1699691)
1990
46
Uremic pruritus. Clinical and experimental studies. (2773616)
1989
47
Uremic pruritus treated with ultraviolet light. (7365958)
1980
48
Uremic pruritus: a review. (380932)
1979
49
Ultraviolet phototherapy of uremic pruritus. Long-term results and possible mechanism of action. (464448)
1979
50
Relief of uremic pruritus with ultraviolet phototherapy. (865585)
1977

Variations for Uremic Pruritus

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Expression for genes affiliated with Uremic Pruritus

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Search GEO for disease gene expression data for Uremic Pruritus.

Pathways for genes affiliated with Uremic Pruritus

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Pathways related to Uremic Pruritus according to GeneCards Suite gene sharing:

(show all 29)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4IL6, IL18
29.4IL6, IL18
39.4IL18, IL6
4
Show member pathways
9.4IL6, IL18
5
Show member pathways
9.4IL6, IL18
69.4IL6, IL18
7
Show member pathways
9.4IL18, IL6
89.1IL2, IL18
99.1IL2, IL18
10
Show member pathways
Immune response IL 12 induced IFN gamma production58
9.1IL18, IL2
11
Show member pathways
IL-9 Signaling Pathway36
Development Thrombopoietin regulated cell processes58
IL-7 Signaling Pathway36
Immune response IL 9 signaling pathway58
9.1IL6, IL2
129.1IL2, IL6
13
Show member pathways
Type III interferon signaling36
9.1IL6, IL2
149.1IL2, IL6
159.1IL2, IL6
169.1IL2, IL6
17
Show member pathways
8.6IL6, IL18, IL2
18
Show member pathways
8.6IL6, IL18, IL2
19
Show member pathways
8.6IL6, IL18, IL2
20
Show member pathways
8.6IL6, IL18, IL2
21
Show member pathways
IL23-mediated signaling events36
Immune response IL 10 signaling pathway58
Angiopoietin receptor Tie2-mediated signaling36
Development PDGF signaling via STATs and NF kB58
Development Angiopoietin Tie2 signaling58
8.6IL6, IL18, IL2
22
Show member pathways
8.6IL2, IL18, IL6
23
Show member pathways
IL27-mediated signaling events36
8.6IL6, IL18, IL2
24
Show member pathways
8.6IL2, IL18, IL6
25
Show member pathways
8.6IL6, IL18, IL2
26
Show member pathways
8.6IL2, IL18, IL6
278.6IL6, IL18, IL2
28
Show member pathways
8.6IL6, IL18, IL2
29
Show member pathways
8.6IL2, IL18, IL6

Compounds for genes affiliated with Uremic Pruritus

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Compounds related to Uremic Pruritus according to GeneCards Suite gene sharing:

(show top 50)    (show all 97)
idCompoundScoreTop Affiliating Genes
1hydroxide439.9OPRK1, IL18
2anakinra43 1210.8IL18, IL6
3naltrexone43 28 49 1212.7SLC17A5, OPRK1
4imiquimod43 59 28 1212.7IL6, IL18
5buprenorphine43 28 1211.7SLC17A5, OPRK1
6heroin43 49 1211.7OPRK1, SLC17A5
7groalpha439.6IL18, IL6
8tepoxalin439.6IL6, IL2
9bucillamine439.5IL2, IL6
10taurine chloramine439.5IL6, IL2
11levamisole43 1210.5IL2, IL18
12lipoteichoic acid439.4IL6, IL18
13rosuvastatin43 49 28 1212.4SLC17A5, IL6
14ranitidine43 28 24 1212.4IL2, IL18
15zoledronic acid439.4IL2, IL6
16okt3439.3IL6, IL2
17lidocaine43 28 1211.3OPRK1, SLC17A5
18con a439.3IL18, IL2
19nicotine43 28 49 1212.3OPRK1, SLC17A5, IL18
20triptolide439.2IL6, IL2
21atorvastatin43 49 28 24 1213.2IL18, IL6, SLC17A5
22rosiglitazone28 43 49 24 1213.2IL6, IL18, SLC17A5
23simvastatin43 49 59 28 24 1214.2IL18, SLC17A5, IL6
24endotoxin439.2IL18, IL6, SLC17A5
25ethanol43 49 24 1212.2OPRK1, IL18, SLC17A5
26methotrexate49 43 1211.2IL18, IL6, SLC17A5
27epinephrine43 24 1211.2IL6, SLC17A5, IL18
28n acetylcysteine439.2SLC17A5, IL18, IL6
29fibrinogen439.1SLC17A5, IL6, IL18
30il-12439.1IL18, IL6, IL2
31gm-csf43 2810.1IL6, IL18, IL2
32polyinosinic-polycytidylic acid439.1IL6, IL18, IL2
33il 10439.0IL18, IL6, IL2
34pentoxifylline43 1210.0IL6, IL18, IL2
35ifn-alpha439.0IL6, IL2, IL18
36thalidomide43 49 59 1212.0IL2, IL18, IL6
37rantes439.0IL2, IL6, IL18
38indomethacin43 28 59 1212.0IL18, IL2, IL6
39ribavirin43 49 1210.9IL18, SLC17A5, IL2
40tacrolimus43 49 1210.9IL2, IL18, SLC17A5
41histamine43 28 2410.9IL18, IL2, IL6
42lactate438.8IL6, IL18, SLC17A5
43pge1438.8IL18, SLC17A5, OPRK1, IL6
44norepinephrine43 24 1210.8IL18, IL6, SLC17A5, OPRK1
45lipid438.6IL6, IL18, OPRK1, SLC17A5
46neopterin438.4IL2, SLC17A5, IL18, IL6
47prednisolone43 28 1210.4SLC17A5, IL2, IL18, IL6
48cyclosporin a43 28 5910.4IL2, IL6, SLC17A5, IL18
49pge2438.3IL2, IL18, IL6
50tyrosine437.9OPRK1, IL6, IL18, IL2, SLC17A5

GO Terms for genes affiliated with Uremic Pruritus

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Cellular components related to Uremic Pruritus according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056158.6IL6, IL18, IL2

Biological processes related to Uremic Pruritus according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1defense response to virusGO:00516079.5OPRK1, IL6
2positive regulation of tissue remodelingGO:00341059.3IL18, IL2
3positive regulation of immunoglobulin secretionGO:00510249.3IL6, IL2
4positive regulation of interleukin-17 productionGO:00327409.3IL18, IL2
5natural killer cell activationGO:00301019.2IL18, IL2
6positive regulation of activated T cell proliferationGO:00421049.2IL2, IL18
7positive regulation of interferon-gamma productionGO:00327299.0IL2, IL18
8positive regulation of inflammatory responseGO:00507298.8IL18, IL2
9immune responseGO:00069558.7OPRK1, IL18, IL2

Molecular functions related to Uremic Pruritus according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:00080839.1IL6, IL2
2cytokine activityGO:00051258.3IL6, IL18, IL2

Products for genes affiliated with Uremic Pruritus

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  • Antibodies
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Sources for Uremic Pruritus

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet