MCID: URM005
MIFTS: 28

Uremic Pruritus malady

Summaries for Uremic Pruritus

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63Wikipedia, 32MalaCards
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Wikipedia:63 Uremic pruritus (also known as \"Renal pruritus\") is caused by chronic renal failure and is the most... more...

MalaCards: Uremic Pruritus is related to peritonitis and viral hepatitis. An important gene associated with Uremic Pruritus is OPRK1 (opioid receptor, kappa 1), and among its related pathways are African trypanosomiasis and Malaria. The compounds pentoxifylline and prednisolone have been mentioned in the context of this disorder. Related mouse phenotypes are digestive/alimentary and behavior/neurological.

Aliases & Classifications for Uremic Pruritus

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Sources:
48Orphanet, 60UMLS, 61UMLS via Orphanet
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Characteristics (Orphanet epidemiological data):

48
uremic pruritus:
Prevalence: 1-5/10000


Aliases & Descriptions:

uremic pruritus 48 60


External Ids:

UMLS via Orphanet61 C1262019

Related Diseases for Uremic Pruritus

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Uremic Pruritus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 74)
idRelated DiseaseScoreTop Affiliating Genes
1peritonitis30.3IL6
2viral hepatitis30.1SLC17A5
3hepatitis10.1
4dermatitis10.0IL18
5alcohol dependence10.0OPRK1
6periodontal disease10.0IL6
7atopy10.0IL18
8asthma10.0IL18
9pneumonia10.0IL6
10diabetes mellitus10.0IL6
11cholestasis10.0SLC17A5
12hepatic encephalopathy10.0SLC17A5
13liver cirrhosis10.0SLC17A5
14allergic rhinitis10.0IL18
15cholangitis10.0SLC17A5
16meningitis10.0IL6
17nephritis10.0IL18
18lupus erythematosus10.0IL18
19myositis10.0SLC17A5
20paraneoplastic syndromes10.0IL6
21scrub typhus10.0SLC17A5
22hypercholesterolemia10.0SLC17A5
23schizophrenia10.0OPRK1
24capillary leak syndrome10.0IL2
25myasthenia gravis10.0IL2
26leprosy10.0IL2
27encephalomyelitis10.0IL2
28diarrhea10.0IL2
29dementia10.0OPRK1
30hellp syndrome10.0SLC17A5
31sarcoma10.0IL2
32plasmacytoma10.0IL6
33alzheimer's disease10.0OPRK1, IL6
34adult-onset still's disease10.0IL6, IL18
35arthritis10.0IL18, IL6
36synovitis10.0IL18, IL6
37ischemia10.0SLC17A5, OPRK1
38malignant glioma10.0IL2
39endometriosis10.0IL6
40toxic shock syndrome10.0IL2
41atherosclerosis10.0IL6, IL18
42pancreatitis10.0SLC17A5, IL6
43hepatitis c10.0IL18, SLC17A5
44galactosemia10.0IL18, SLC17A5
45coronary heart disease10.0IL18, IL6
46periodontitis10.0SLC17A5, IL6
47t-cell large granular lymphocyte leukemia10.0IL2, IL18
48inflammatory bowel disease10.0IL6, IL2
49connective tissue disease10.0IL2, IL6
50acute graft versus host disease10.0IL18, IL2

Graphical network of the top 20 diseases related to Uremic Pruritus:



Diseases related to uremic pruritus

Clinical Features for Uremic Pruritus

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Drugs & Therapeutics for Uremic Pruritus

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Uremic Pruritus

Drug clinical trials:

Search ClinicalTrials for Uremic Pruritus

Search NIH Clinical Center for Uremic Pruritus

Search CenterWatch for Uremic Pruritus

Genetic Tests for Uremic Pruritus

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Anatomical Context for Uremic Pruritus

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Animal Models for Uremic Pruritus or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Uremic Pruritus:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.2IL2, IL6, IL18, OPRK1
2MP:00053867.2SLC17A5, IL2, IL6, IL18, OPRK1

Publications for Uremic Pruritus

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Genetic Variations for Uremic Pruritus

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Expression for genes affiliated with Uremic Pruritus

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Uremic Pruritus

Search GEO for disease gene expression data for Uremic Pruritus.

Pathways for genes affiliated with Uremic Pruritus

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Sources:
29KEGG, 12EMD Millipore, 37NCBI BioSystems Database, 53Reactome, 52R&D Systems, 51QIAGEN
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Compounds for genes affiliated with Uremic Pruritus

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Sources:
44Novoseek, 11DrugBank, 28IUPHAR, 59Tocris Bioscience, 24HMDB, 49PharmGKB
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Compounds related to Uremic Pruritus according to GeneCards/GeneDecks:

(show top 50)    (show all 69)
idCompoundScoreTop Affiliating Genes
1pentoxifylline44 1111.4IL18
2prednisolone44 28 1112.3SLC17A5
3cyclosporin a44 28 5912.3SLC17A5
4endotoxin4410.3SLC17A5
5hydroxide449.9OPRK1, IL18
6norepinephrine44 11 2411.8OPRK1, SLC17A5
7anakinra44 1110.8IL6, IL18
8imiquimod44 28 59 1112.8IL6, IL18
9naltrexone44 49 28 1112.7SLC17A5, OPRK1
10buprenorphine44 28 1111.7SLC17A5, OPRK1
11heroin44 49 1111.7SLC17A5, OPRK1
12groalpha449.7IL18, IL6
13tepoxalin449.6IL6, IL2
14bucillamine449.5IL6, IL2
15taurine chloramine449.5IL2, IL6
16rantes449.5IL6, IL2
17lipoteichoic acid449.5IL6, IL18
18levamisole44 1110.5IL2, IL18
19rosuvastatin44 49 28 1112.4IL6, SLC17A5
20ranitidine44 28 11 2412.4IL2, IL18
21lidocaine44 28 1111.4OPRK1, SLC17A5
22zoledronic acid449.4IL6, IL2
23okt3449.4IL6, IL2
24triptolide449.3IL6, IL2
25con a449.3IL2, IL18
26nicotine44 49 28 1112.3SLC17A5, OPRK1, IL18
27atorvastatin44 49 28 11 2413.2IL6, IL18, SLC17A5
28rosiglitazone44 49 28 11 2413.2IL6, IL18, SLC17A5
29simvastatin44 49 59 28 11 2414.2IL18, IL6, SLC17A5
30methotrexate44 49 1111.2IL18, SLC17A5, IL6
31ethanol44 49 11 2412.2SLC17A5, OPRK1, IL18
32epinephrine44 11 2411.2IL6, SLC17A5, IL18
33n acetylcysteine449.2IL18, IL6, SLC17A5
34etanercept44 49 1111.1IL6, IL18
35fibrinogen449.1IL18, SLC17A5, IL6
36il-12449.1IL6, IL18, IL2
37polyinosinic-polycytidylic acid449.1IL2, IL6, IL18
38il 10449.0IL2, IL18, IL6
39ifn-alpha449.0IL2, IL18, IL6
402,5-oligoadenylate449.0IL2, IL6
41thalidomide44 49 59 1112.0IL2, IL6, IL18
42indomethacin44 59 28 1111.9IL6, IL2, IL18
43ribavirin44 49 1110.9IL2, SLC17A5, IL18
44tacrolimus44 49 1110.9IL2, IL18, SLC17A5
45histamine44 28 2410.9IL6, IL18, IL2
46pge1448.8IL18, OPRK1, IL6, SLC17A5
47pge2448.6IL18, IL2, IL6
48lipid448.6IL18, OPRK1, SLC17A5, IL6
49neopterin448.4IL2, SLC17A5, IL18, IL6
50tyrosine447.9SLC17A5, IL2, IL18, IL6, OPRK1

GO Terms for genes affiliated with Uremic Pruritus

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16Gene Ontology
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Biological processes related to Uremic Pruritus according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of chemokine productionGO:0327229.6IL6, IL18
2cellular response to hydrogen peroxideGO:0703019.5IL6, IL18
3response to coldGO:0094099.4IL18, IL6
4positive regulation of tissue remodelingGO:0341059.4IL2, IL18
5positive regulation of immunoglobulin secretionGO:0510249.4IL6, IL2
6positive regulation of interleukin-17 productionGO:0327409.3IL2, IL18
7natural killer cell activationGO:0301019.3IL2, IL18
8positive regulation of activated T cell proliferationGO:0421049.2IL2, IL18
9positive regulation of inflammatory responseGO:0507299.1IL2, IL18
10positive regulation of interferon-gamma productionGO:0327299.0IL18, IL2
11immune responseGO:0069558.4IL18, OPRK1, IL2

Molecular functions related to Uremic Pruritus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051258.6IL2, IL6, IL18

Products for genes affiliated with Uremic Pruritus

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  • Antibodies
  • Proteins
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  • Antibodies

Sources for Uremic Pruritus

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet