MCID: URM005
MIFTS: 34

Uremic Pruritus malady

Summaries for Uremic Pruritus

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Uremic pruritus (also known as \"Renal pruritus\") is caused by chronic renal failure and is the most... more...

MalaCards: Uremic Pruritus is related to viral hepatitis and hepatitis c. An important gene associated with Uremic Pruritus is OPRK1 (opioid receptor, kappa 1), and among its related pathways are African trypanosomiasis and Malaria. The compounds pentoxifylline and prednisolone have been mentioned in the context of this disorder. Affiliated tissues include lymph node, kidney and skin, and related mouse phenotypes are digestive/alimentary and behavior/neurological.

Aliases & Classifications for Uremic Pruritus

Sources:
49Orphanet, 61UMLS, 62UMLS via Orphanet
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Characteristics (Orphanet epidemiological data):

49
uremic pruritus:
Prevalence: 1-5/10000


Aliases & Descriptions:

uremic pruritus 49 61


External Ids:

UMLS via Orphanet62 C1262019

Related Diseases for Uremic Pruritus

Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Uremic Pruritus:



Diseases related to uremic pruritus

Clinical Features for Uremic Pruritus

Drugs & Therapeutics for Uremic Pruritus

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Uremic Pruritus

Drug clinical trials:

Search ClinicalTrials for Uremic Pruritus

Search NIH Clinical Center for Uremic Pruritus

Search CenterWatch for Uremic Pruritus

Genetic Tests for Uremic Pruritus

Anatomical Context for Uremic Pruritus

Sources:
33MalaCards
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MalaCards organs/tissues related to Uremic Pruritus:

33
Lymph node, Kidney, Skin, B cells

Animal Models for Uremic Pruritus or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Uremic Pruritus:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.2IL2, IL6, IL18, OPRK1
2MP:00053867.2SLC17A5, IL2, IL6, IL18, OPRK1

Publications for Uremic Pruritus

Sources:
51PubMed
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Articles related to Uremic Pruritus:

(show top 50)    (show all 101)
idTitleAuthorsYear
1
Effective treatment of uremic pruritus and acquired perforating dermatosis with amitriptyline. (23425115)
2013
2
Effect of acupressure on patients in Turkey receiving hemodialysis treatment for uremic pruritus. (23981400)
2013
3
Use of pregabalin in the management of chronic uremic pruritus. (22819436)
2013
4
Uremic pruritus and serum phosphorus level. (23945893)
2013
5
Effect of sertraline on uremic pruritus improvement in ESRD patients. (22973512)
2012
6
Efficacy of omega-3 fatty acids supplementation in treatment of uremic pruritus in hemodialysis patients: a double-blind randomized controlled trial. (23115713)
2012
7
Uremic pruritus. (21983988)
2012
8
Uremic pruritus in hemodialysis patients: treatment with desloratidine versus gabapentin. (22850916)
2012
9
Acupuncture for treating uremic pruritus in patients with end-stage renal disease: a systematic review. (21796811)
2010
10
Elevated C-reactive protein level in hemodialysis patients with moderate/severe uremic pruritus: a potential mediator of high overall mortality. (20350963)
2010
11
Topical capsaicin therapy for uremic pruritus in patients on hemodialysis. (20404425)
2010
12
Nalfurafine hydrochloride: a new drug for the treatment of uremic pruritus in hemodialysis patients. (19584962)
2009
13
Effects of thermal therapy on uremic pruritus and biochemical parameters in patients having haemodialysis. (19737321)
2009
14
Uremic pruritus, cytokines, and polymethylmethacrylate artificial kidney. (18422797)
2008
15
Uremic pruritus]. (18578330)
2008
16
Uremic pruritus. (17429345)
2007
17
Clinical characteristics of uremic pruritus in patients undergoing haemodialysis. (16499798)
2006
18
Therapeutic effect of topical gamma-linolenic acid on refractory uremic pruritus. (16797388)
2006
19
Etiology and prognostic significance of severe uremic pruritus in chronic hemodialysis patients. (16672924)
2006
20
Uremic pruritus. (17211814)
2006
21
Efficacy and tolerance of the cream containing structured physiological lipids with endocannabinoids in the treatment of uremic pruritus: a preliminary study. (16324422)
2005
22
Kappa-opioid system in uremic pruritus: multicenter, randomized, double-blind, placebo-controlled clinical studies. (16251241)
2005
23
A comparative study on the effects of naltrexone and loratadine on uremic pruritus. (15178915)
2004
24
Uremic pruritus: still an important clinical problem. (15523377)
2004
25
Prevalence and characterization of uremic pruritus in patients undergoing hemodialysis: uremic pruritus is still a major problem for patients with end-stage renal disease. (14576662)
2003
26
Uremic pruritus: a clinical study of maintenance hemodialysis patients. (12432992)
2002
27
Evaluation of uremic pruritus at an outpatient hemodialysis unit. (12380906)
2002
28
Uremic pruritus--an update. (11684792)
2001
29
Ondansetron therapy for uremic pruritus in hemodialysis patients. (10793015)
2000
30
The pathophysiological puzzle of uremic pruritus--insights and speculations from therapeutic and epidemiological studies. (11117239)
2000
31
Uremic pruritus: an unresolved problem in hemodialysis patients. (10224488)
1999
32
Viral hepatitis infection should be considered for evaluating uremic pruritus in continuous ambulatory peritoneal dialysis patients. (9681157)
1998
33
Histamine and serotonin in uremic pruritus: effect of ondansetron in CAPD-pruritic patients. (9578065)
1998
34
Is aluminum toxicity responsible for uremic pruritus in chronic hemodialysis patients? (9031270)
1997
35
Uremic pruritus in CAPD patients. (9358524)
1997
36
L-carnitine does not alleviate uremic pruritus in hemodialysis patients. (9069470)
1997
37
Uremic pruritus. (8791145)
1996
38
Uremic pruritus. (8679435)
1995
39
Uremic pruritus is a poor prognostic factor of outcome. (7612742)
1995
40
Thalidomide for the treatment of uremic pruritus: a crossover randomized double-blind trial. (7936015)
1994
41
Uremic pruritus: a review. (1738396)
1992
42
Erythropoietin therapy for uremic pruritus. (1495537)
1992
43
Erythropoietin treatment does not improve uremic pruritus. (1511055)
1992
44
Erythropoietin therapy for uremic pruritus. (1495538)
1992
45
Identifying effective treatments for uremic pruritus. (1839393)
1991
46
Uremic pruritus. Clinical and experimental studies. (2773616)
1989
47
Treatment of uremic pruritus with blue light. (4070031)
1985
48
Naloxone in the treatment of uremic pruritus: a case history. (6467691)
1984
49
Uremic pruritus treated with ultraviolet light. (7365958)
1980
50
Relief of uremic pruritus with ultraviolet phototherapy. (865585)
1977

Genetic Variations for Uremic Pruritus

Expression for genes affiliated with Uremic Pruritus

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Uremic Pruritus

Search GEO for disease gene expression data for Uremic Pruritus.

Pathways for genes affiliated with Uremic Pruritus

Sources:
30KEGG, 12EMD Millipore, 38NCBI BioSystems Database, 54Reactome, 53R&D Systems, 52QIAGEN
See all sources

Compounds for genes affiliated with Uremic Pruritus

Sources:
45Novoseek, 11DrugBank, 29IUPHAR, 60Tocris Bioscience, 24HMDB, 50PharmGKB
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Compounds related to Uremic Pruritus according to GeneCards/GeneDecks:

(show top 50)    (show all 69)
idCompoundScoreTop Affiliating Genes
1pentoxifylline45 1111.4IL18
2prednisolone45 29 1112.3SLC17A5
3cyclosporin a45 29 6012.3SLC17A5
4endotoxin4510.3SLC17A5
5hydroxide459.9IL18, OPRK1
6norepinephrine45 11 2411.8OPRK1, SLC17A5
7anakinra45 1110.8IL6, IL18
8imiquimod45 29 60 1112.7IL6, IL18
9naltrexone45 50 29 1112.7SLC17A5, OPRK1
10buprenorphine45 29 1111.7SLC17A5, OPRK1
11heroin45 50 1111.7SLC17A5, OPRK1
12groalpha459.7IL18, IL6
13tepoxalin459.6IL2, IL6
14bucillamine459.5IL2, IL6
15taurine chloramine459.5IL2, IL6
16lipoteichoic acid459.5IL6, IL18
17rantes459.5IL2, IL6
18levamisole45 1110.5IL2, IL18
19rosuvastatin45 50 29 1112.4SLC17A5, IL6
20ranitidine45 29 11 2412.4IL2, IL18
21lidocaine45 29 1111.4OPRK1, SLC17A5
22zoledronic acid459.4IL2, IL6
23okt3459.4IL6, IL2
24con a459.3IL18, IL2
25triptolide459.3IL6, IL2
26nicotine45 50 29 1112.3OPRK1, IL18, SLC17A5
27atorvastatin45 50 29 11 2413.2SLC17A5, IL6, IL18
28rosiglitazone45 50 29 11 2413.2SLC17A5, IL6, IL18
29simvastatin45 50 60 29 11 2414.2IL18, IL6, SLC17A5
30methotrexate45 50 1111.2IL18, IL6, SLC17A5
31ethanol45 50 11 2412.2OPRK1, IL18, SLC17A5
32epinephrine45 11 2411.2IL18, IL6, SLC17A5
33n acetylcysteine459.2SLC17A5, IL6, IL18
34etanercept45 50 1111.1IL6, IL18
35fibrinogen459.1SLC17A5, IL6, IL18
36il-12459.1IL2, IL6, IL18
37polyinosinic-polycytidylic acid459.1IL2, IL6, IL18
38il 10459.0IL2, IL6, IL18
39ifn-alpha459.0IL2, IL6, IL18
402,5-oligoadenylate459.0IL2, IL6
41thalidomide45 50 60 1112.0IL18, IL6, IL2
42indomethacin45 60 29 1111.9IL18, IL6, IL2
43ribavirin45 50 1110.9SLC17A5, IL2, IL18
44tacrolimus45 50 1110.9SLC17A5, IL2, IL18
45histamine45 29 2410.9IL18, IL6, IL2
46pge1458.8SLC17A5, IL6, IL18, OPRK1
47pge2458.6IL2, IL6, IL18
48lipid458.6SLC17A5, IL6, IL18, OPRK1
49neopterin458.4SLC17A5, IL2, IL6, IL18
50tyrosine457.9OPRK1, IL18, IL6, IL2, SLC17A5

GO Terms for genes affiliated with Uremic Pruritus

Sources:
16Gene Ontology
See all sources

Biological processes related to Uremic Pruritus according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of chemokine productionGO:0327229.6IL6, IL18
2cellular response to hydrogen peroxideGO:0703019.5IL6, IL18
3response to coldGO:0094099.4IL6, IL18
4positive regulation of tissue remodelingGO:0341059.4IL2, IL18
5positive regulation of immunoglobulin secretionGO:0510249.4IL2, IL6
6positive regulation of interleukin-17 productionGO:0327409.3IL18, IL2
7natural killer cell activationGO:0301019.3IL2, IL18
8positive regulation of activated T cell proliferationGO:0421049.2IL18, IL2
9positive regulation of inflammatory responseGO:0507299.1IL2, IL18
10positive regulation of interferon-gamma productionGO:0327299.0IL18, IL2
11immune responseGO:0069558.4IL2, IL18, OPRK1

Molecular functions related to Uremic Pruritus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051258.6IL2, IL6, IL18

Products for genes affiliated with Uremic Pruritus

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Uremic Pruritus

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet