MCID: URM005
MIFTS: 40

Uremic Pruritus malady

Rare diseases category
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Summaries for Uremic Pruritus

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Wikipedia:65 Uremic pruritus (also known as uraemic pruritus or renal pruritus) is caused by chronic renal failure... more...

MalaCards based summary: Uremic Pruritus is related to blindness and scrub typhus. An important gene associated with Uremic Pruritus is OPRK1 (opioid receptor, kappa 1), and among its related pathways are African trypanosomiasis and Malaria. The compounds hydroxide and anakinra have been mentioned in the context of this disorder. Affiliated tissues include skin, kidney and lymph node, and related mouse phenotypes are digestive/alimentary and growth/size/body.

Aliases & Classifications for Uremic Pruritus

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Sources:
48Orphanet, 62UMLS, 63UMLS via Orphanet
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Uremic Pruritus, Aliases & Descriptions:

Name: Uremic Pruritus 48 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Characteristics (Orphanet epidemiological data):

48
uremic pruritus:
Prevalence: 1-5/10000


External Ids:

UMLS via Orphanet63 C1262019

Related Diseases for Uremic Pruritus

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Diseases related to Uremic Pruritus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 49)
idRelated DiseaseScoreTop Affiliating Genes
1blindness10.5
2scrub typhus10.4SLC17A5
3galactosemia10.3IL6
4peritonitis10.3
5capillary leak syndrome10.3IL2
6adult-onset still's disease10.2IL6, IL18
7hepatitis10.1
8mycosis fungoides10.1
9restless legs syndrome10.1
10kidney disease10.1
11viral hepatitis10.1
12synovitis10.1IL6, IL18
13pneumonia10.1IL6
14hepatitis b10.1IL18, SLC17A5
15periodontitis10.1SLC17A5, IL6
16colitis10.1IL6, IL18
17t-cell large granular lymphocyte leukemia10.1IL2, IL18
18pancreatitis10.1SLC17A5, IL6
19acute graft versus host disease10.0IL2, IL18
20pulmonary sarcoidosis10.0IL18, IL2
21pulmonary tuberculosis10.0IL18, IL2
22skin disease10.0IL6, IL2
23acquired immunodeficiency syndrome10.0IL2, IL6
24graft versus host disease10.0IL2, IL18
25connective tissue disease10.0IL2, IL6
26inflammatory bowel disease10.0IL2, IL6
27osteoarthritis10.0OPRK1, IL6, IL18
28eosinophilia10.0IL18, IL2
29coronary artery anomaly10.0IL18, IL6
30sarcoidosis9.9IL18, IL2
31acute pancreatitis9.9SLC17A5, IL6, IL18
32periodontal disease9.9SLC17A5, IL6, IL18
33pre-eclampsia9.9IL18, IL6, SLC17A5
34primary hyperoxaluria9.9IL6, IL2
35insulin resistance9.9SLC17A5, IL6, IL18
36obesity9.9IL18, IL6, SLC17A5
37atopic dermatitis9.9IL18, IL2
38vascular disease9.9IL6, IL2
39lymphopenia9.8IL6, IL18, IL2
40systemic lupus erythematosus9.8IL6, IL18, IL2
41psoriasis9.8IL2, IL18, IL6
42multiple sclerosis9.8IL6, IL18, IL2
43hypersensitivity reaction type ii disease9.8IL6, IL18, IL2
44leukopenia9.8SLC17A5, IL6, IL2
45hepatitis c9.8IL2, IL18, SLC17A5
46thrombocytopenia9.8IL2, IL6, SLC17A5
47ipex syndrome9.6OPRK1, IL6, IL18, IL2
48rheumatoid arthritis9.6IL2, IL18, IL6, OPRK1
49viral infectious disease9.6IL2, IL18, IL6, SLC17A5

Graphical network of the top 20 diseases related to Uremic Pruritus:



Diseases related to uremic pruritus

Symptoms for Uremic Pruritus

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Drugs & Therapeutics for Uremic Pruritus

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Drug clinical trials:

Search ClinicalTrials for Uremic Pruritus

Search NIH Clinical Center for Uremic Pruritus

Genetic Tests for Uremic Pruritus

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Anatomical Context for Uremic Pruritus

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MalaCards organs/tissues related to Uremic Pruritus:

32
Skin, Kidney, Lymph node

Animal Models for Uremic Pruritus or affiliated genes

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MGI Mouse Phenotypes related to Uremic Pruritus:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.1IL2, IL18, IL6, OPRK1
2MP:00053788.0SLC17A5, IL6, IL18, IL2
3MP:00053847.7IL2, IL18, IL6, SLC17A5
4MP:00053867.5SLC17A5, OPRK1, IL6, IL18, IL2

Publications for Uremic Pruritus

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Articles related to Uremic Pruritus:

(show top 50)    (show all 104)
idTitleAuthorsYear
1
Quiz page August 2014: pruritus in a dialysis patient. Mycosis fungoides (folliculotropic variant) in a dialysis patient, with rare presentation of persistent generalized pruritus with characteristics of uremic pruritus without skin lesions. (25060007)
2014
2
Efficacy and Safety of Gabapentin for Uremic Pruritus and Restless Legs Syndrome in Conservatively Managed Patients With Chronic Kidney Disease. (25220049)
2014
3
Interleukin-31 is associated with uremic pruritus in patients receiving hemodialysis. (25270263)
2014
4
Uremic pruritus. (24402092)
2014
5
Uremic pruritus pathogenesis, revisited. (25366503)
2014
6
The effect of ergocalciferol on uremic pruritus severity: a randomized controlled trial. (23453391)
2013
7
Uremic pruritus, dialysis adequacy, and metabolic profiles in hemodialysis patients: a prospective 5-year cohort study. (23940749)
2013
8
Longitudinal predictors of uremic pruritus. (24209894)
2013
9
Effective treatment of uremic pruritus and acquired perforating dermatosis with amitriptyline. (23425115)
2013
10
Effect of acupressure on patients in Turkey receiving hemodialysis treatment for uremic pruritus. (23981400)
2013
11
Effect of sertraline on uremic pruritus improvement in ESRD patients. (22973512)
2012
12
Baby oil therapy for uremic pruritus in haemodialysis patients. (22093006)
2012
13
Efficacy of omega-3 fatty acids supplementation in treatment of uremic pruritus in hemodialysis patients: a double-blind randomized controlled trial. (23115713)
2012
14
Uremic pruritus. (21983988)
2012
15
Acupuncture for treating uremic pruritus in patients with end-stage renal disease: a systematic review. (21796811)
2010
16
A longitudinal study of uremic pruritus in hemodialysis patients. (20558560)
2010
17
A pramoxine-based anti-itch lotion is more effective than a control lotion for the treatment of uremic pruritus in adult hemodialysis patients. (18821119)
2009
18
Gabapentin and uremic pruritus in hemodialysis patients. (19212903)
2009
19
Nicotinamide as a potential novel addition to the anti-uremic pruritus weaponry. (19237824)
2009
20
Characteristics of uremic pruritus in hemodialysis patients: data from a single center. (18794819)
2008
21
Uremic pruritus, cytokines, and polymethylmethacrylate artificial kidney. (18422797)
2008
22
Effect of oral granisetron in uremic pruritus. (17675729)
2007
23
Uremic pruritus. (17429345)
2007
24
Clinical characteristics of uremic pruritus in patients undergoing haemodialysis. (16499798)
2006
25
Therapeutic effect of topical gamma-linolenic acid on refractory uremic pruritus. (16797388)
2006
26
Efficacy and safety of a new kappa-opioid receptor agonist for the treatment of uremic pruritus. (16932462)
2006
27
An epidemiology study of patients with uremic pruritus. (16836494)
2006
28
Etiology and prognostic significance of severe uremic pruritus in chronic hemodialysis patients. (16672924)
2006
29
Cromolyn sodium: a potential therapy for uremic pruritus? (16623673)
2006
30
A comparative study on the effects of naltrexone and loratadine on uremic pruritus. (15178915)
2004
31
Uremic pruritus: still an important clinical problem. (15523377)
2004
32
Uremic pruritus: a clinical study of maintenance hemodialysis patients. (12432992)
2002
33
Management of uremic pruritus. (10833778)
2000
34
Naltrexone does not relieve uremic pruritus: results of a randomized, double-blind, placebo-controlled crossover study. (10703675)
2000
35
Ondansetron therapy for uremic pruritus in hemodialysis patients. (10793015)
2000
36
Uremic pruritus: an unresolved problem in hemodialysis patients. (10224488)
1999
37
Is aluminum toxicity responsible for uremic pruritus in chronic hemodialysis patients? (9031270)
1997
38
Potentially toxic self-treatment of uremic pruritus with topical pyrethroid insecticides. (8997483)
1997
39
Uremic pruritus in CAPD patients. (9358524)
1997
40
L-carnitine does not alleviate uremic pruritus in hemodialysis patients. (9069470)
1997
41
Uremic pruritus. (8791145)
1996
42
Uremic pruritus. (8679435)
1995
43
Optimal dialysis improves uremic pruritus. (7872318)
1995
44
Uremic pruritus: a review. (1738396)
1992
45
Uremic pruritus in patients on hemodialysis or continuous ambulatory peritoneal dialysis (CAPD). The role of plasma histamine and skin mast cells. (1699691)
1990
46
Uremic pruritus. Clinical and experimental studies. (2773616)
1989
47
Uremic pruritus treated with ultraviolet light. (7365958)
1980
48
Uremic pruritus: a review. (380932)
1979
49
Ultraviolet phototherapy of uremic pruritus. Long-term results and possible mechanism of action. (464448)
1979
50
Relief of uremic pruritus with ultraviolet phototherapy. (865585)
1977

Variations for Uremic Pruritus

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Expression for genes affiliated with Uremic Pruritus

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Expression patterns in normal tissues for genes affiliated with Uremic Pruritus

Search GEO for disease gene expression data for Uremic Pruritus.

Pathways for genes affiliated with Uremic Pruritus

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Pathways related to Uremic Pruritus according to GeneCards/GeneDecks:

(show all 29)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4IL6, IL18
29.4IL6, IL18
39.4IL18, IL6
4
Show member pathways
9.4IL6, IL18
5
Show member pathways
9.4IL6, IL18
69.4IL6, IL18
7
Show member pathways
9.4IL18, IL6
89.1IL2, IL18
99.1IL2, IL18
10
Show member pathways
Immune response IL 12 induced IFN gamma production60
9.1IL18, IL2
11
Show member pathways
IL-9 Signaling Pathway37
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway37
Immune response IL 9 signaling pathway60
9.1IL6, IL2
129.1IL2, IL6
13
Show member pathways
Type III interferon signaling37
9.1IL6, IL2
149.1IL2, IL6
159.1IL2, IL6
169.1IL2, IL6
17
Show member pathways
8.6IL6, IL18, IL2
18
Show member pathways
8.6IL6, IL18, IL2
19
Show member pathways
8.6IL6, IL18, IL2
20
Show member pathways
8.6IL6, IL18, IL2
21
Show member pathways
IL23-mediated signaling events37
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling37
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
8.6IL6, IL18, IL2
22
Show member pathways
8.6IL2, IL18, IL6
23
Show member pathways
IL27-mediated signaling events37
8.6IL6, IL18, IL2
24
Show member pathways
8.6IL2, IL18, IL6
25
Show member pathways
8.6IL6, IL18, IL2
26
Show member pathways
8.6IL2, IL18, IL6
278.6IL6, IL18, IL2
28
Show member pathways
8.6IL6, IL18, IL2
29
Show member pathways
8.6IL2, IL18, IL6

Compounds for genes affiliated with Uremic Pruritus

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Compounds related to Uremic Pruritus according to GeneCards/GeneDecks:

(show top 50)    (show all 97)
idCompoundScoreTop Affiliating Genes
1hydroxide449.9OPRK1, IL18
2anakinra44 1110.8IL18, IL6
3naltrexone44 28 50 1112.7SLC17A5, OPRK1
4imiquimod44 61 28 1112.7IL6, IL18
5buprenorphine44 28 1111.7SLC17A5, OPRK1
6heroin44 50 1111.7OPRK1, SLC17A5
7groalpha449.6IL18, IL6
8tepoxalin449.6IL6, IL2
9bucillamine449.5IL2, IL6
10taurine chloramine449.5IL6, IL2
11levamisole44 1110.5IL2, IL18
12lipoteichoic acid449.4IL6, IL18
13rosuvastatin44 50 28 1112.4SLC17A5, IL6
14ranitidine44 28 24 1112.4IL2, IL18
15zoledronic acid449.4IL2, IL6
16okt3449.3IL6, IL2
17lidocaine44 28 1111.3OPRK1, SLC17A5
18con a449.3IL18, IL2
19nicotine44 28 50 1112.3OPRK1, SLC17A5, IL18
20triptolide449.2IL6, IL2
21atorvastatin44 50 28 24 1113.2IL18, IL6, SLC17A5
22rosiglitazone28 44 50 24 1113.2IL6, IL18, SLC17A5
23simvastatin44 50 61 28 24 1114.2IL18, SLC17A5, IL6
24endotoxin449.2IL18, IL6, SLC17A5
25ethanol44 50 24 1112.2OPRK1, IL18, SLC17A5
26methotrexate50 44 1111.2IL18, IL6, SLC17A5
27epinephrine44 24 1111.2IL6, SLC17A5, IL18
28n acetylcysteine449.2SLC17A5, IL18, IL6
29fibrinogen449.1SLC17A5, IL6, IL18
30il-12449.1IL18, IL6, IL2
31gm-csf44 2810.1IL6, IL18, IL2
32polyinosinic-polycytidylic acid449.1IL6, IL18, IL2
33il 10449.0IL18, IL6, IL2
34pentoxifylline44 1110.0IL6, IL18, IL2
35ifn-alpha449.0IL6, IL2, IL18
36thalidomide44 50 61 1112.0IL2, IL18, IL6
37rantes449.0IL2, IL6, IL18
38indomethacin44 28 61 1112.0IL18, IL2, IL6
39ribavirin44 50 1110.9IL18, SLC17A5, IL2
40tacrolimus44 50 1110.9IL2, IL18, SLC17A5
41histamine44 28 2410.9IL18, IL2, IL6
42lactate448.8IL6, IL18, SLC17A5
43pge1448.8IL18, SLC17A5, OPRK1, IL6
44norepinephrine44 24 1110.8IL18, IL6, SLC17A5, OPRK1
45lipid448.6IL6, IL18, OPRK1, SLC17A5
46neopterin448.4IL2, SLC17A5, IL18, IL6
47prednisolone44 28 1110.4SLC17A5, IL2, IL18, IL6
48cyclosporin a44 28 6110.4IL2, IL6, SLC17A5, IL18
49pge2448.3IL2, IL18, IL6
50tyrosine447.9OPRK1, IL6, IL18, IL2, SLC17A5

GO Terms for genes affiliated with Uremic Pruritus

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Cellular components related to Uremic Pruritus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.6IL6, IL18, IL2

Biological processes related to Uremic Pruritus according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1defense response to virusGO:0516079.5OPRK1, IL6
2positive regulation of tissue remodelingGO:0341059.3IL18, IL2
3positive regulation of immunoglobulin secretionGO:0510249.3IL6, IL2
4positive regulation of interleukin-17 productionGO:0327409.3IL18, IL2
5natural killer cell activationGO:0301019.2IL18, IL2
6positive regulation of activated T cell proliferationGO:0421049.2IL2, IL18
7positive regulation of interferon-gamma productionGO:0327299.0IL2, IL18
8positive regulation of inflammatory responseGO:0507298.8IL18, IL2
9immune responseGO:0069558.7OPRK1, IL18, IL2

Molecular functions related to Uremic Pruritus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:0080839.1IL6, IL2
2cytokine activityGO:0051258.3IL6, IL18, IL2

Products for genes affiliated with Uremic Pruritus

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Sources for Uremic Pruritus

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet