MCID: URM005
MIFTS: 40

Uremic Pruritus malady

Rare diseases category

Summaries for Uremic Pruritus

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66Wikipedia, 34MalaCards
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Wikipedia:66 Uremic pruritus (also known as uraemic pruritus or renal pruritus) is caused by chronic renal failure... more...

MalaCards: Uremic Pruritus is related to blindness and peritonitis. An important gene associated with Uremic Pruritus is OPRK1 (opioid receptor, kappa 1), and among its related pathways are African trypanosomiasis and Malaria. The compounds hydroxide and anakinra have been mentioned in the context of this disorder. Affiliated tissues include skin, lymph node and kidney, and related mouse phenotypes are digestive/alimentary and growth/size/body.

Aliases & Classifications for Uremic Pruritus

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50Orphanet, 63UMLS, 64UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Characteristics (Orphanet epidemiological data):

50
uremic pruritus:
Prevalence: 1-5/10000


Aliases & Descriptions:

uremic pruritus 50 63


External Ids:

UMLS via Orphanet64 C1262019

Related Diseases for Uremic Pruritus

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Uremic Pruritus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 45)
idRelated DiseaseScoreTop Affiliating Genes
1blindness10.5
2peritonitis10.3
3hepatitis10.1
4viral hepatitis10.1
5scrub typhus10.1SLC17A5
6galactosemia10.1IL6
7capillary leak syndrome10.1IL2
8adult-onset still's disease10.0IL6, IL18
9synovitis10.0IL6, IL18
10pneumonia10.0IL6
11hepatitis b10.0IL18, SLC17A5
12periodontitis10.0SLC17A5, IL6
13t-cell large granular lymphocyte leukemia10.0IL2, IL18
14acute graft versus host disease10.0IL2, IL18
15pancreatitis10.0SLC17A5, IL6
16pulmonary sarcoidosis10.0IL18, IL2
17pulmonary tuberculosis10.0IL18, IL2
18skin disease10.0IL6, IL2
19acquired immunodeficiency syndrome10.0IL2, IL6
20graft versus host disease10.0IL2, IL18
21connective tissue disease10.0IL2, IL6
22osteoarthritis10.0OPRK1, IL6, IL18
23inflammatory bowel disease10.0IL2, IL6
24eosinophilia10.0IL18, IL2
25coronary artery disease10.0IL18, IL6
26sarcoidosis10.0IL18, IL2
27acute pancreatitis10.0SLC17A5, IL6, IL18
28periodontal disease10.0SLC17A5, IL6, IL18
29pre-eclampsia10.0IL18, IL6, SLC17A5
30primary hyperoxaluria10.0IL6, IL2
31insulin resistance10.0SLC17A5, IL6, IL18
32atopic dermatitis10.0IL18, IL2
33vascular disease10.0IL6, IL2
34obesity10.0IL18, IL6, SLC17A5
35lymphopenia10.0IL6, IL18, IL2
36systemic lupus erythematosus10.0IL6, IL18, IL2
37psoriasis10.0IL2, IL18, IL6
38multiple sclerosis10.0IL6, IL18, IL2
39hypersensitivity reaction type ii disease10.0IL6, IL18, IL2
40leukopenia9.9SLC17A5, IL6, IL2
41hepatitis c9.9IL2, IL18, SLC17A5
42thrombocytopenia9.9IL2, IL6, SLC17A5
43ipex syndrome9.9OPRK1, IL6, IL18, IL2
44rheumatoid arthritis9.9IL2, IL18, IL6, OPRK1
45viral infectious disease9.9IL2, IL18, IL6, SLC17A5

Graphical network of the top 20 diseases related to Uremic Pruritus:



Diseases related to uremic pruritus

Symptoms for Uremic Pruritus

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Drugs & Therapeutics for Uremic Pruritus

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Uremic Pruritus

Drug clinical trials:

Search ClinicalTrials for Uremic Pruritus

Search NIH Clinical Center for Uremic Pruritus

Search CenterWatch for Uremic Pruritus

Genetic Tests for Uremic Pruritus

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Anatomical Context for Uremic Pruritus

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34MalaCards
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MalaCards organs/tissues related to Uremic Pruritus:

34
Skin, Lymph node, Kidney

Animal Models for Uremic Pruritus or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Uremic Pruritus:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.1IL2, IL18, IL6, OPRK1
2MP:00053788.0SLC17A5, IL6, IL18, IL2
3MP:00053847.7IL2, IL18, IL6, SLC17A5
4MP:00053867.5SLC17A5, OPRK1, IL6, IL18, IL2

Publications for Uremic Pruritus

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Sources:
53PubMed
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Articles related to Uremic Pruritus:

(show top 50)    (show all 98)
idTitleAuthorsYear
1
Uremic pruritus. (24402092)
2014
2
The effect of ergocalciferol on uremic pruritus severity: a randomized controlled trial. (23453391)
2013
3
Uremic pruritus, dialysis adequacy, and metabolic profiles in hemodialysis patients: a prospective 5-year cohort study. (23940749)
2013
4
Longitudinal predictors of uremic pruritus. (24209894)
2013
5
Effective treatment of uremic pruritus and acquired perforating dermatosis with amitriptyline. (23425115)
2013
6
Effect of acupressure on patients in Turkey receiving hemodialysis treatment for uremic pruritus. (23981400)
2013
7
Effect of sertraline on uremic pruritus improvement in ESRD patients. (22973512)
2012
8
Baby oil therapy for uremic pruritus in haemodialysis patients. (22093006)
2012
9
Efficacy of omega-3 fatty acids supplementation in treatment of uremic pruritus in hemodialysis patients: a double-blind randomized controlled trial. (23115713)
2012
10
Uremic pruritus. (21983988)
2012
11
The role of ondansetron in the management of cholestatic or uremic pruritus--a systematic review. (22727254)
2012
12
Acupuncture for treating uremic pruritus in patients with end-stage renal disease: a systematic review. (21796811)
2010
13
A longitudinal study of uremic pruritus in hemodialysis patients. (20558560)
2010
14
A pramoxine-based anti-itch lotion is more effective than a control lotion for the treatment of uremic pruritus in adult hemodialysis patients. (18821119)
2009
15
Gabapentin and uremic pruritus in hemodialysis patients. (19212903)
2009
16
Nalfurafine hydrochloride: a new drug for the treatment of uremic pruritus in hemodialysis patients. (19584962)
2009
17
Nicotinamide as a potential novel addition to the anti-uremic pruritus weaponry. (19237824)
2009
18
Characteristics of uremic pruritus in hemodialysis patients: data from a single center. (18794819)
2008
19
Uremic pruritus, cytokines, and polymethylmethacrylate artificial kidney. (18422797)
2008
20
Role of gabapentin in the treatment of uremic pruritus. (18492782)
2008
21
Effect of oral granisetron in uremic pruritus. (17675729)
2007
22
Uremic pruritus. (17429345)
2007
23
Clinical characteristics of uremic pruritus in patients undergoing haemodialysis. (16499798)
2006
24
Therapeutic effect of topical gamma-linolenic acid on refractory uremic pruritus. (16797388)
2006
25
Efficacy and safety of a new kappa-opioid receptor agonist for the treatment of uremic pruritus. (16932462)
2006
26
An epidemiology study of patients with uremic pruritus. (16836494)
2006
27
Etiology and prognostic significance of severe uremic pruritus in chronic hemodialysis patients. (16672924)
2006
28
Cromolyn sodium: a potential therapy for uremic pruritus? (16623673)
2006
29
A comparative study on the effects of naltrexone and loratadine on uremic pruritus. (15178915)
2004
30
Uremic pruritus: still an important clinical problem. (15523377)
2004
31
Uremic pruritus: a clinical study of maintenance hemodialysis patients. (12432992)
2002
32
Management of uremic pruritus. (10833778)
2000
33
Naltrexone does not relieve uremic pruritus: results of a randomized, double-blind, placebo-controlled crossover study. (10703675)
2000
34
Ondansetron therapy for uremic pruritus in hemodialysis patients. (10793015)
2000
35
Uremic pruritus: an unresolved problem in hemodialysis patients. (10224488)
1999
36
Is aluminum toxicity responsible for uremic pruritus in chronic hemodialysis patients? (9031270)
1997
37
Potentially toxic self-treatment of uremic pruritus with topical pyrethroid insecticides. (8997483)
1997
38
Uremic pruritus in CAPD patients. (9358524)
1997
39
L-carnitine does not alleviate uremic pruritus in hemodialysis patients. (9069470)
1997
40
Uremic pruritus. (8791145)
1996
41
Uremic pruritus. (8679435)
1995
42
Optimal dialysis improves uremic pruritus. (7872318)
1995
43
Uremic pruritus: a review. (1738396)
1992
44
Uremic pruritus in patients on hemodialysis or continuous ambulatory peritoneal dialysis (CAPD). The role of plasma histamine and skin mast cells. (1699691)
1990
45
Uremic pruritus. Clinical and experimental studies. (2773616)
1989
46
Uremic pruritus treated with ultraviolet light. (7365958)
1980
47
Uremic pruritus: a review. (380932)
1979
48
Ultraviolet phototherapy of uremic pruritus. Long-term results and possible mechanism of action. (464448)
1979
49
Ultraviolet phototherapy of uremic pruritus. (511436)
1979
50
Relief of uremic pruritus with ultraviolet phototherapy. (865585)
1977

Variations for Uremic Pruritus

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Expression for genes affiliated with Uremic Pruritus

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Uremic Pruritus

Search GEO for disease gene expression data for Uremic Pruritus.

Pathways for genes affiliated with Uremic Pruritus

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Sources:
51PathCards, 31KEGG, 56Reactome, 39NCBI BioSystems Database, 61Thomson Reuters, 55R&D Systems, 54QIAGEN
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Pathways related to Uremic Pruritus according to GeneCards/GeneDecks:

(show all 29)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4IL6, IL18
29.4IL6, IL18
39.4IL18, IL6
4
Show member pathways
9.4IL6, IL18
5
Show member pathways
9.4IL6, IL18
69.4IL6, IL18
7
Show member pathways
9.4IL18, IL6
89.1IL2, IL18
99.1IL2, IL18
10
Show member pathways
Immune response IL 12 induced IFN gamma production61
9.1IL18, IL2
11
Show member pathways
IL-9 Signaling Pathway39
Development Thrombopoietin regulated cell processes61
IL-7 Signaling Pathway39
Immune response IL 9 signaling pathway61
9.1IL6, IL2
129.1IL2, IL6
13
Show member pathways
Type III interferon signaling39
9.1IL6, IL2
149.1IL2, IL6
159.1IL2, IL6
169.1IL2, IL6
17
Show member pathways
8.6IL6, IL18, IL2
18
Show member pathways
8.6IL6, IL18, IL2
19
Show member pathways
8.6IL6, IL18, IL2
20
Show member pathways
8.6IL6, IL18, IL2
21
Show member pathways
IL23-mediated signaling events39
Immune response IL 10 signaling pathway61
Angiopoietin receptor Tie2-mediated signaling39
Development PDGF signaling via STATs and NF kB61
Development Angiopoietin Tie2 signaling61
8.6IL6, IL18, IL2
22
Show member pathways
8.6IL2, IL18, IL6
23
Show member pathways
IL27-mediated signaling events39
8.6IL6, IL18, IL2
24
Show member pathways
8.6IL2, IL18, IL6
25
Show member pathways
8.6IL6, IL18, IL2
26
Show member pathways
8.6IL2, IL18, IL6
278.6IL6, IL18, IL2
28
Show member pathways
8.6IL6, IL18, IL2
29
Show member pathways
8.6IL2, IL18, IL6

Compounds for genes affiliated with Uremic Pruritus

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Sources:
46Novoseek, 12DrugBank, 30IUPHAR, 52PharmGKB, 62Tocris Bioscience, 25HMDB
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Compounds related to Uremic Pruritus according to GeneCards/GeneDecks:

(show top 50)    (show all 97)
idCompoundScoreTop Affiliating Genes
1hydroxide469.9OPRK1, IL18
2anakinra46 1210.8IL18, IL6
3naltrexone46 30 52 1212.7SLC17A5, OPRK1
4imiquimod46 62 30 1212.7IL6, IL18
5buprenorphine46 30 1211.7SLC17A5, OPRK1
6heroin46 52 1211.7OPRK1, SLC17A5
7groalpha469.6IL18, IL6
8tepoxalin469.6IL6, IL2
9bucillamine469.5IL2, IL6
10taurine chloramine469.5IL6, IL2
11levamisole46 1210.5IL2, IL18
12lipoteichoic acid469.4IL6, IL18
13rosuvastatin46 52 30 1212.4SLC17A5, IL6
14ranitidine46 30 25 1212.4IL2, IL18
15zoledronic acid469.4IL2, IL6
16okt3469.3IL6, IL2
17lidocaine46 30 1211.3OPRK1, SLC17A5
18con a469.3IL18, IL2
19nicotine46 30 52 1212.3OPRK1, SLC17A5, IL18
20triptolide469.2IL6, IL2
21atorvastatin46 52 30 25 1213.2IL18, IL6, SLC17A5
22rosiglitazone30 46 52 25 1213.2IL6, IL18, SLC17A5
23simvastatin46 52 62 30 25 1214.2IL18, SLC17A5, IL6
24endotoxin469.2IL18, IL6, SLC17A5
25ethanol46 52 25 1212.2OPRK1, IL18, SLC17A5
26methotrexate52 46 1211.2IL18, IL6, SLC17A5
27epinephrine46 25 1211.2IL6, SLC17A5, IL18
28n acetylcysteine469.2SLC17A5, IL18, IL6
29fibrinogen469.1SLC17A5, IL6, IL18
30il-12469.1IL18, IL6, IL2
31gm-csf46 3010.1IL6, IL18, IL2
32polyinosinic-polycytidylic acid469.1IL6, IL18, IL2
33il 10469.0IL18, IL6, IL2
34pentoxifylline46 1210.0IL6, IL18, IL2
35ifn-alpha469.0IL6, IL2, IL18
36thalidomide46 52 62 1212.0IL2, IL18, IL6
37rantes469.0IL2, IL6, IL18
38indomethacin46 30 62 1212.0IL18, IL2, IL6
39ribavirin46 52 1210.9IL18, SLC17A5, IL2
40tacrolimus46 52 1210.9IL2, IL18, SLC17A5
41histamine46 30 2510.9IL18, IL2, IL6
42lactate468.8IL6, IL18, SLC17A5
43pge1468.8IL18, SLC17A5, OPRK1, IL6
44norepinephrine46 25 1210.8IL18, IL6, SLC17A5, OPRK1
45lipid468.6IL6, IL18, OPRK1, SLC17A5
46neopterin468.4IL2, SLC17A5, IL18, IL6
47prednisolone46 30 1210.4SLC17A5, IL2, IL18, IL6
48cyclosporin a46 30 6210.4IL2, IL6, SLC17A5, IL18
49pge2468.3IL2, IL18, IL6
50tyrosine467.9OPRK1, IL6, IL18, IL2, SLC17A5

GO Terms for genes affiliated with Uremic Pruritus

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Sources:
17Gene Ontology
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Cellular components related to Uremic Pruritus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.6IL6, IL18, IL2

Biological processes related to Uremic Pruritus according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1defense response to virusGO:0516079.5OPRK1, IL6
2positive regulation of tissue remodelingGO:0341059.3IL18, IL2
3positive regulation of immunoglobulin secretionGO:0510249.3IL6, IL2
4positive regulation of interleukin-17 productionGO:0327409.3IL18, IL2
5natural killer cell activationGO:0301019.2IL18, IL2
6positive regulation of activated T cell proliferationGO:0421049.2IL2, IL18
7positive regulation of interferon-gamma productionGO:0327299.0IL2, IL18
8positive regulation of inflammatory responseGO:0507298.8IL18, IL2
9immune responseGO:0069558.7OPRK1, IL18, IL2

Molecular functions related to Uremic Pruritus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:0080839.1IL6, IL2
2cytokine activityGO:0051258.3IL6, IL18, IL2

Products for genes affiliated with Uremic Pruritus

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Uremic Pruritus

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet