Aliases & Classifications for Ureter Cancer

MalaCards integrated aliases for Ureter Cancer:

Name: Ureter Cancer 12 14
Ureter Carcinoma 12 52 14 69
Ureteral Benign Neoplasm 12 14
Ureteral Neoplasms 42 69
Malignant Neoplasm of Ureter 69
Malignant Tumour of Ureter 12
Malignant Ureteral Tumor 12
Neoplasm of Ureter 12
Ureteral Carcinoma 12
Ureteral Tumor 12

Characteristics:

HPO:

32
ureter cancer:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

Disease Ontology 12 DOID:11819 DOID:11885 DOID:4939
ICD10 33 C66
ICD9CM 35 189.2
MeSH 42 D014516

Summaries for Ureter Cancer

Disease Ontology : 12 An ureter cancer that is located in the ureter.

MalaCards based summary : Ureter Cancer, also known as ureter carcinoma, is related to regional ureteric cancer and ureter adenocarcinoma, and has symptoms including neoplasm of the ureter An important gene associated with Ureter Cancer is PLAUR (Plasminogen Activator, Urokinase Receptor), and among its related pathways/superpathways are Endochondral Ossification and Lung fibrosis. The drugs Cisplatin and Gemcitabine have been mentioned in the context of this disorder. Affiliated tissues include kidney, prostate and lung, and related phenotypes are cardiovascular system and renal/urinary system

Wikipedia : 72 Ureteral cancer is cancer of the ureters, muscular tubes that propel urine from the kidneys to the... more...

Related Diseases for Ureter Cancer

Diseases related to Ureter Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 78)
id Related Disease Score Top Affiliating Genes
1 regional ureteric cancer 10.9
2 ureter adenocarcinoma 10.9
3 kidney benign neoplasm 10.8
4 legionnaires' disease 10.6 PLAU PLAUR
5 loiasis 10.4 PLAU PLAUR
6 malignant ovarian mixed epithelial neoplasm 10.2 CHGA SYP
7 ampulla of vater small cell carcinoma 10.2 CHGA SYP
8 spinal cord ependymoma 10.2 CHGA SYP
9 ludwig's angina 10.2 CHGA SYP
10 signet ring cell intrahepatic cholangiocarcinoma 10.2 CHGA SYP
11 childhood choriocarcinoma of the ovary 10.2 CHGA SYP
12 osteoblastoma 10.2 CHGA SYP
13 esophagus adenocarcinoma 10.2 CHGA SYP
14 basophilic carcinoma 10.2 CHGA SYP
15 cystitis cystica 10.2 CHGA SYP
16 small intestine cancer, childhood 10.2 CHGA SYP
17 pemphigus vulgaris 10.2 PLAU PLAUR
18 neurogenic thoracic outlet syndrome 10.2 CHGA SYP
19 aicardi-goutieres syndrome 10.2 CHGA SYP
20 diffuse infiltrative lymphocytosis syndrome 10.2 CHGA SYP
21 congenital granular cell tumor 10.2 CHGA SYP
22 reticular pattern testicular yolk sac tumor 10.2 CHGA SYP
23 mast cell neoplasm 10.2 CHGA SYP
24 diffuse lipomatosis 10.2 CHGA SYP
25 pleomorphic xanthoastrocytoma 10.2 CHGA SYP
26 thyroid sarcoma 10.2 CHGA SYP
27 sudden sensorineural hearing loss 10.2 CHGA SYP
28 central nervous system hematologic cancer 10.2 CHGA SYP
29 pituitary dwarfism with large sella turcica 10.2 CHGA SYP
30 dystonia, dopa-responsive, with or without hyperphenylalaninemia 10.2 CHGA MGP
31 pneumonia 10.2 CHGA SYP
32 ethmoid sinus schneiderian papilloma 10.2 CHGA SYP
33 rete ovarii cystadenofibroma 10.2 CHGA SYP
34 pancreatic agenesis 10.2 CHGA SYP
35 nose disease 10.2 CHGA SYP
36 congenital mesoblastic nephroma 10.1 CHGA SYP
37 perianal skin paget's disease 10.1 CHGA SYP
38 cowden syndrome 3 10.1 CHGA SYP
39 tricuspid valve insufficiency 10.1 CHGA SYP
40 brain stem ependymoma 10.1 CHGA SYP
41 pediatric ependymoma 10.1 CHGA SYP
42 gliofibroma 10.1 CHGA SYP
43 group b strep disease in newborns 10.1 CHGA SYP
44 human t-cell leukemia virus type 1 10.1 CHGA SYP
45 central nervous system melanocytic neoplasm 10.1 CHGA SYP
46 calcific tendinitis 10.1 CHGA SYP
47 bladder cancer, childhood 10.1 CHGA SYP
48 carcinoma of unknown primary site, childhood 10.1 CHGA SYP
49 internal auditory canal lipoma 10.1 CHGA SYP
50 anal canal adenocarcinoma 10.1 CHGA SYP

Comorbidity relations with Ureter Cancer via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia
Hydronephrosis Prostatic Hypertrophy
Renal Pelvis Carcinoma Urinary Bladder Cancer

Graphical network of the top 20 diseases related to Ureter Cancer:



Diseases related to Ureter Cancer

Symptoms & Phenotypes for Ureter Cancer

Human phenotypes related to Ureter Cancer:

32
id Description HPO Frequency HPO Source Accession
1 neoplasm of the ureter 32 HP:0100516

MGI Mouse Phenotypes related to Ureter Cancer:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.35 ADRA1A CHGA MGP PLAU PLAUR
2 renal/urinary system MP:0005367 8.92 ADRA1A CHGA MGP PLAUR

Drugs & Therapeutics for Ureter Cancer

Drugs for Ureter Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 143)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved Phase 3,Phase 2,Phase 1 15663-27-1 84093 441203 2767
2
Gemcitabine Approved Phase 3,Phase 2,Phase 1 95058-81-4 60750
3
Carboplatin Approved Phase 3,Phase 2,Phase 1 41575-94-4 10339178 498142 38904
4
Paclitaxel Approved, Vet_approved Phase 3,Phase 2,Phase 1 33069-62-4 36314
5
Doxorubicin Approved, Investigational Phase 3,Phase 1,Phase 2 23214-92-8 31703
6
Methotrexate Approved Phase 3,Phase 2 1959-05-2, 59-05-2 126941
7
Vinblastine Approved Phase 3,Phase 2,Phase 1 865-21-4 13342 241903
8
Pemetrexed Approved, Investigational Phase 3,Phase 2 150399-23-8, 137281-23-3 446556 60843
9
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Phase 2 50-02-2 5743
10
Hydroxocobalamin Approved Phase 3,Phase 2 13422-51-0 11953898 5460373 44475014
11
Bevacizumab Approved, Investigational Phase 3 216974-75-3
12
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3,Phase 2,Phase 1 59-30-3 6037
13
leucovorin Approved, Nutraceutical Phase 3,Phase 2 58-05-9 143 6006
14
Cyanocobalamin Approved, Nutraceutical Phase 3,Phase 2 68-19-9 44176380
15
Doxil Approved June 1999 Phase 3,Phase 1,Phase 2 31703
16 Anti-Infective Agents Phase 3,Phase 2,Phase 1
17 Antimetabolites Phase 3,Phase 2,Phase 1
18 Antimetabolites, Antineoplastic Phase 3,Phase 2,Phase 1
19 Antimitotic Agents Phase 3,Phase 2,Phase 1
20 Antiviral Agents Phase 3,Phase 2,Phase 1
21 Immunosuppressive Agents Phase 3,Phase 2,Phase 1
22 Angiogenesis Inhibitors Phase 3,Phase 2,Phase 1
23 Angiogenesis Modulating Agents Phase 3,Phase 2,Phase 1
24 Albumin-Bound Paclitaxel Phase 3,Phase 2,Phase 1
25 Antineoplastic Agents, Phytogenic Phase 3,Phase 2,Phase 1
26 Anti-Bacterial Agents Phase 3,Phase 1,Phase 2
27 Antibiotics, Antitubercular Phase 3,Phase 1,Phase 2
28 Antirheumatic Agents Phase 3,Phase 2,Phase 1
29 Dermatologic Agents Phase 3,Phase 2
30 Folic Acid Antagonists Phase 3,Phase 2
31 Nucleic Acid Synthesis Inhibitors Phase 3,Phase 2
32 Topoisomerase Inhibitors Phase 3,Phase 1,Phase 2
33 Vitamin B Complex Phase 3,Phase 2,Phase 1
34 Autonomic Agents Phase 3,Phase 2,Early Phase 1
35 Micronutrients Phase 3,Phase 2,Phase 1
36 Peripheral Nervous System Agents Phase 3,Phase 2,Phase 1,Early Phase 1
37 Trace Elements Phase 3,Phase 2,Phase 1
38 Vitamins Phase 3,Phase 2,Phase 1
39 Antibodies Phase 3,Phase 2,Phase 1
40 Antibodies, Monoclonal Phase 3,Phase 2,Phase 1
41 Immunoglobulins Phase 3,Phase 2,Phase 1
42 Antiemetics Phase 3,Phase 2
43 Anti-Inflammatory Agents Phase 3,Phase 2,Phase 1
44 Antineoplastic Agents, Hormonal Phase 3,Phase 2
45 BB 1101 Phase 3,Phase 2
46 Dexamethasone acetate Phase 3,Phase 2 1177-87-3
47 Gastrointestinal Agents Phase 3,Phase 2
48 glucocorticoids Phase 3,Phase 2
49 Hematinics Phase 3,Phase 2
50 HIV Protease Inhibitors Phase 3,Phase 2

Interventional clinical trials:

(show top 50) (show all 121)

id Name Status NCT ID Phase Drugs
1 Cisplatin Plus Gemcitabine With or Without Paclitaxel in Treating Patients With Stage IV Urinary Tract Cancer Completed NCT00022191 Phase 3 cisplatin;gemcitabine hydrochloride;paclitaxel
2 Two-Drug Combination Chemotherapy Compared With Four-Drug Combination Chemotherapy in Treating Patients With Advanced Cancer of the Urothelium Completed NCT00003376 Phase 3 carboplatin;cisplatin;doxorubicin hydrochloride;methotrexate;paclitaxel;vinblastine
3 Combination Chemotherapy in Treating Patients With Transitional Cell Cancer of the Urothelium Completed NCT00014274 Phase 2, Phase 3 carboplatin;gemcitabine hydrochloride;methotrexate;vinblastine sulfate
4 Pemetrexed Maintenance in Patients With Urothelial Carcinoma Who Completed First Line Platinum-based Chemotherapy Recruiting NCT03193788 Phase 3 pemetrexed;Folic Acid;Vitamin B12 Injection;Dexamethasone
5 Four Cycles Versus Six Cycles of Cisplatin-based Chemotherapy in Metastatic Urothelial Carcinoma Recruiting NCT03296306 Phase 3 Treatment duration of cisplatin based chemotherapy
6 A Phase III Randomised Trial of Peri-Operative Chemotherapy Versus sUrveillance in Upper Tract Urothelial Cancer (POUT) Recruiting NCT01993979 Phase 3 Chemotherapy
7 Radical Versus Simple Hysterectomy and Pelvic Node Dissection in Patients With Low-risk Early Stage Cervical Cancer (SHAPE) Recruiting NCT01658930 Phase 3
8 Gemcitabine Hydrochloride and Cisplatin With or Without Bevacizumab in Treating Patients With Advanced Urinary Tract Cancer Active, not recruiting NCT00942331 Phase 3 Cisplatin;Gemcitabine Hydrochloride
9 Carboplatin and Gemcitabine Hydrochloride With or Without Vandetanib as First-Line Therapy in Treating Patients With Locally Advanced or Metastatic Urinary Tract Cancer Unknown status NCT01191892 Phase 2 carboplatin;gemcitabine hydrochloride;vandetanib;Placebo
10 Combination Chemotherapy Plus Filgrastim in Treating Patients With Locally Recurrent or Advanced Urothelium Cancer Unknown status NCT00005958 Phase 2 docetaxel;gemcitabine hydrochloride
11 Sunitinib Malate in Treating Patients With Locally Recurrent, Locally Advanced, Unresectable, or Metastatic Urinary Tract Cancer Unknown status NCT01118039 Phase 2 sunitinib malate
12 Surgery Plus Combination Chemotherapy and Radiation Therapy in Treating Patients With Cancer of the Urinary Tract Unknown status NCT00006111 Phase 2 cisplatin;fluorouracil
13 Gemcitabine Hydrochloride, Cisplatin, and Sunitinib Malate as First-Line Therapy in Treating Patients With Locally Advanced And/or Metastatic Transitional Cell Carcinoma of the Urothelium Unknown status NCT01089088 Phase 2 cisplatin;gemcitabine hydrochloride;sunitinib malate
14 Study of Genexol-PM in Patients With Advanced Urothelial Cancer Previously Treated With Gemcitabine and Platinum Completed NCT01426126 Phase 2 Genexol PM
15 TRC105 in Adults With Advanced/Metastatic Urothelial Carcinoma Completed NCT01328574 Phase 2 TRC105
16 Arsenic Trioxide in Treating Patients With Urothelial Cancer Completed NCT00009867 Phase 2 arsenic trioxide
17 A Phase II Study of AZD4877 (a Novel Anti-mitotic Agent) in Advanced Bladder Cancer Completed NCT00661609 Phase 2 AZD4877
18 Phase II Trial Of PS-341 (Bortezomib) In Patients With Previously Treated Advanced Urothelial Tract Transitional Cell Carcinoma Completed NCT00072150 Phase 2 bortezomib
19 Bortezomib in Treating Patients With Advanced or Metastatic Transitional Cell Cancer of the Bladder, Renal Pelvis, or Ureter Completed NCT00066352 Phase 2 bortezomib
20 Sorafenib in Treating Patients With Advanced or Metastatic Cancer of the Urinary Tract Completed NCT00112671 Phase 2 sorafenib tosylate
21 Oxaliplatin in Treating Patients With Metastatic Bladder Cancer Completed NCT00004203 Phase 2 oxaliplatin
22 Gefitinib Plus Combination Chemotherapy in Treating Patients With Locally Advanced or Metastatic Bladder Cancer Completed NCT00041106 Phase 2 gemcitabine hydrochloride;cisplatin;gefitinib
23 Combination Chemotherapy in Treating Patients With Metastatic or Locally Advanced Bladder Cancer Completed NCT00003105 Phase 1, Phase 2 cisplatin;doxorubicin hydrochloride;gemcitabine hydrochloride;ifosfamide;paclitaxel
24 R115777 in Treating Patients With Advanced Bladder Cancer Completed NCT00006376 Phase 2 chemotherapy;tipifarnib
25 Gemcitabine, Paclitaxel, and Cisplatin in Treating Patients With Advanced Cancer of the Urothelium Completed NCT00310011 Phase 2 cisplatin;gemcitabine hydrochloride;paclitaxel
26 Neoadjuvant Ifosfamide, Doxorubicin, Gemcitabine, and Cisplatin in Treating Patients Who Are Undergoing Radical Cystectomy for Locally Advanced Carcinoma (Cancer) of the Urothelium Completed NCT00080795 Phase 2 cisplatin;doxorubicin hydrochloride;gemcitabine hydrochloride;ifosfamide
27 Combination Chemotherapy Following Surgery in Treating Patients With Urinary Tract Cancer Completed NCT00028860 Phase 2 carboplatin;gemcitabine hydrochloride;ifosfamide;paclitaxel
28 Intravenous BI 6727 (Volasertib) in 2nd Line Treatment of Urothelial Cancer Completed NCT01023958 Phase 2 BI 6727, IV infusion
29 Pemetrexed Disodium and Gemcitabine in Treating Patients With Advanced Cancer of the Urothelium Completed NCT00053209 Phase 2 gemcitabine hydrochloride;pemetrexed disodium
30 S0306, Irinotecan in Treating Patients With Recurrent or Refractory Advanced Transitional Cell Cancer of the Urothelium Previously Treated With Chemotherapy Completed NCT00066612 Phase 2 irinotecan hydrochloride
31 SCH 66336 Plus Gemcitabine in Treating Patients With Advanced Cancer of the Urinary Tract Completed NCT00006351 Phase 2 gemcitabine hydrochloride;lonafarnib
32 S0219, Combination Chemotherapy Followed By Observation or Surgery in Patients With Stage II or Stage III Cancer of the Urothelium Completed NCT00045630 Phase 2 carboplatin;gemcitabine;paclitaxel
33 Piritrexim in Treating Patients With Advanced Cancer of the Urinary Tract Completed NCT00002914 Phase 2 piritrexim
34 Sunitinib in Treating Patients With Progressive Metastatic Transitional Cell Cancer of the Urothelium Completed NCT00397488 Phase 2 sunitinib malate
35 Sunitinib as Second-Line Therapy in Treating Patients With Locally Advanced or Metastatic Transitional Cell Cancer Completed NCT00792025 Phase 2 sunitinib malate
36 Gemcitabine Hydrochloride, Cisplatin, and Temsirolimus as First-Line Therapy in Treating Patients With Locally Advanced and/or Metastatic Transitional Cell Cancer of the Urothelium Completed NCT01090466 Phase 1, Phase 2 cisplatin;gemcitabine hydrochloride;temsirolimus
37 Nitrocamptothecin in Treating Patients With Metastatic Cancer of the Urinary Tract Completed NCT00006026 Phase 2 rubitecan
38 Combination Chemotherapy in Treating Patients With Advanced Cancer of the Urothelium and Decreased Kidney Function Completed NCT00005644 Phase 2 gemcitabine hydrochloride;paclitaxel
39 S0031, ZD 1839 in Treating Patients With Advanced Cancer of the Urinary Tract Completed NCT00014144 Phase 2 gefitinib
40 Docetaxel and Gemcitabine in Treating Patients With Progressive Regional or Metastatic Bladder Cancer Completed NCT00004223 Phase 2 docetaxel;gemcitabine hydrochloride
41 Fluorouracil in Treating Patients With Recurrent or Metastatic Bladder Cancer Completed NCT00003175 Phase 2 fluorouracil
42 Pazopanib Hydrochloride in Treating Patients With Metastatic Urethral Cancer or Bladder Cancer That Has Relapsed or Not Responded to Treatment Completed NCT01031875 Phase 2 pazopanib hydrochloride
43 Eribulin Mesylate Administered in Combination With Gemcitabine Plus Cisplatin Versus Gemcitabine Plus Cisplatin Alone as First-Line Therapy for Locally Advanced or Metastatic Bladder Cancer Completed NCT01126749 Phase 1, Phase 2 gemcitabine plus cisplatin;E7389 in combination with gemcitabine plus cisplatin
44 Trastuzumab and Combination Chemotherapy in Treating Patients With Locally Recurrent or Metastatic Urinary Tract Cancer Completed NCT00005831 Phase 2 paclitaxel;carboplatin;gemcitabine hydrochloride
45 Gemcitabine, Paclitaxel, Doxorubicin in Metastatic or Unresectable Bladder Cancer With Decreased Kidney Function Completed NCT00478361 Phase 2 Gemcitabine hydrochloride;Paclitaxel;Doxorubicin hydrochloride;Pegfilgrastim
46 Pazopanib in Treating Patients With Metastatic Urothelial Cancer Completed NCT00471536 Phase 2 pazopanib hydrochloride
47 Ixabepilone in Treating Patients With Advanced Urinary Tract Cancer Completed NCT00021099 Phase 2 ixabepilone
48 VEGF Trap in Treating Patients With Recurrent, Locally Advanced, or Metastatic Cancer of the Urothelium Completed NCT00407485 Phase 2
49 A Trial With Vinflunine in Patients With Metastatic Bladder Cancer and Impaired Renal Function Recruiting NCT02665039 Phase 2 Vinflunine;Gemcitabine;Carboplatin
50 Afatinib in Advanced Refractory Urothelial Cancer Recruiting NCT02122172 Phase 2 afatinib dimaleate

Search NIH Clinical Center for Ureter Cancer

Cochrane evidence based reviews: ureteral neoplasms

Genetic Tests for Ureter Cancer

Anatomical Context for Ureter Cancer

MalaCards organs/tissues related to Ureter Cancer:

39
Kidney, Prostate, Lung, Liver, Endothelial, Lymph Node, Cervix

Publications for Ureter Cancer

Articles related to Ureter Cancer:

id Title Authors Year
1
Segmental ureterectomy does not compromise the oncologic outcome compared with nephroureterectomy for pure ureter cancer. ( 24202956 )
2013
2
Papillary urothelial carcinoma in sigmoid neobladder suggesting 'intraluminal seeding' from ureter cancer. ( 19138291 )
2008
3
Concomitant occurrence of a primary renal NHL and of a papillary urothelial ureter cancer. ( 17725112 )
2007
4
The Copenhagen case-control study of renal pelvis and ureter cancer: role of analgesics. ( 2606581 )
1989
5
The Copenhagen case-control study of renal pelvis and ureter cancer: role of smoking and occupational exposures. ( 3356489 )
1988

Variations for Ureter Cancer

Expression for Ureter Cancer

Search GEO for disease gene expression data for Ureter Cancer.

Pathways for Ureter Cancer

Pathways related to Ureter Cancer according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.22 MGP PLAU
2 11.17 PLAU TERT
3 11.11 PLAU PLAUR
4 10.94 PLAU PLAUR
5 10.83 PLAU PLAUR
6 10.33 MGP PLAU PLAUR
7 10.07 PLAU PLAUR

GO Terms for Ureter Cancer

Cellular components related to Ureter Cancer according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 specific granule membrane GO:0035579 8.62 PLAU PLAUR

Biological processes related to Ureter Cancer according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 fibrinolysis GO:0042730 8.96 PLAU PLAUR
2 positive regulation of cardiac muscle contraction GO:0060452 8.62 ADRA1A CHGA

Sources for Ureter Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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