MCID: URT010
MIFTS: 47

Ureteral Obstruction malady

Nephrological diseases category
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Summaries for Ureteral Obstruction

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MalaCards based summary: Ureteral Obstruction is related to renal fibrosis and colitis. An important gene associated with Ureteral Obstruction is BMP7 (bone morphogenetic protein 7), and among its related pathways are TGF-beta Signaling Pathway and SMAD Signaling Network. The compounds enalapril and irbesartan have been mentioned in the context of this disorder. Affiliated tissues include kidney, bone and bone marrow, and related mouse phenotypes are immune system and renal/urinary system.

Aliases & Classifications for Ureteral Obstruction

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Ureteral Obstruction, Aliases & Descriptions:

Name: Ureteral Obstruction 8 10 44


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological diseases


External Ids:

Disease Ontology8 DOID:5199
SNOMED-CT57 197807001
ICD9CM27 593.4

Related Diseases for Ureteral Obstruction

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Graphical network of the top 20 diseases related to Ureteral Obstruction:



Diseases related to ureteral obstruction

Symptoms for Ureteral Obstruction

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Drugs & Therapeutics for Ureteral Obstruction

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Drug clinical trials:

Search ClinicalTrials for Ureteral Obstruction

Search NIH Clinical Center for Ureteral Obstruction

Genetic Tests for Ureteral Obstruction

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Anatomical Context for Ureteral Obstruction

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MalaCards organs/tissues related to Ureteral Obstruction:

32
Kidney, Bone, Bone marrow, Colon, Prostate, Monocytes, Endothelial, Liver, Myeloid, Lymph node, Cortex, Smooth muscle, Breast, Uterus

Animal Models for Ureteral Obstruction or affiliated genes

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MGI Mouse Phenotypes related to Ureteral Obstruction:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053877.6AGTR1, BMP7, CLU, TGFB1, PTGS1
2MP:00053677.5AGTR1, BMP7, CLU, TGFB1, PTGS1
3MP:00053857.3PTGS1, TGFB1, CLU, BMP7, AGTR1

Publications for Ureteral Obstruction

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Articles related to Ureteral Obstruction:

(show top 50)    (show all 567)
idTitleAuthorsYear
1
Combination Therapy with Losartan and I+-Tocopherol in Acute Ureteral Obstruction-Induced Renal Excretory Dysfunction and Acidification Defect. (25031488)
2014
2
Effect of unilateral ureteral obstruction and anti-angiotensin II treatment on renal tubule cell apoptosis and interstitial fibrosis in rats. (25144992)
2014
3
ROS dependence of cyclooxygenase-2 induction in rats subjected to unilateral ureteral obstruction. (24226522)
2014
4
Oleanolic acid attenuates renal fibrosis in mice with unilateral ureteral obstruction via facilitating nuclear translocation of Nrf2. (24393202)
2014
5
Metallic Ureteral Stents in Malignant Ureteral Obstruction: Clinical Factors Predicting Stent Failure. (24397490)
2014
6
The effect of carvedilol on serum and tissue oxidative stress parameters in partial ureteral obstruction induced rat model. (23257252)
2013
7
Ulinastatin inhibits unilateral ureteral obstruction-induced renal interstitial fibrosis in rats via transforming growth factor I^ (TGF-I^)/Smad signalling pathways. (23318600)
2013
8
Five-year experience with metallic stents for chronic ureteral obstruction. (23485505)
2013
9
The protective effects of metyrosine, lacidipine, clonidine, and moxonidine on kidney damage induced by unilateral ureteral obstruction in rats. (22202971)
2012
10
Commentary to 'Ureteral obstruction following injection of dextranomer/hyaluronic acid copolymer: an infrequent but relevant complication'. (22056308)
2012
11
Dermatan sulfate reduces monocyte chemoattractant protein 1 and TGF-I^ production, as well as macrophage recruitment and myofibroblast accumulation in mice with unilateral ureteral obstruction. (21833458)
2011
12
Vitamin E ameliorates renal fibrosis in ureteral obstruction: role of maintaining BMP-7 during epithelial-to-mesenchymal transition. (22619901)
2011
13
Renal parenchymal fibrosis and atrophy are not correlated with upper tract dilatation: long-term study of partial unilateral ureteral obstruction in neonatal mice. (21527217)
2011
14
Editorial comment on: Ureteral obstruction: is the full metallic double-pigtail stent the way to go? (19232818)
2010
15
Postpartum ovarian vein thrombosis presenting as ureteral obstruction. (22767678)
2010
16
Fucosylated chondroitin sulfate attenuates renal fibrosis in animals submitted to unilateral ureteral obstruction: a P-selectin-mediated event? (20861075)
2010
17
Nephrocutaneous bypass in ureteral obstruction. (20156649)
2010
18
Renal uptakes of 99mTc-MAG3, 99mTc-DTPA, and 99mTc-DMSA in rabbits with unilateral ureteral obstruction. (20363984)
2010
19
Noninvasive assessment of acute ureteral obstruction with diffusion-weighted MR imaging: a prospective study. (19567650)
2009
20
Melatonin attenuates unilateral ureteral obstruction-induced renal injury by reducing oxidative stress, iNOS, MAPK, and NF-kB expression. (19530942)
2009
21
Atorvastatin ameliorates tubulointerstitial fibrosis and protects renal function in chronic partial ureteral obstruction cases. (19692013)
2009
22
Evaluation of urothelial stretch-induced cyclooxygenase-2 expression in a mouse ureteral obstruction model. (19193137)
2009
23
Endoscopic management of a ureteral obstruction caused by endometriosis: a case report. (19502140)
2009
24
Persistent bilateral ureteral obstruction secondary to endometriosis despite treatment with an aromatase inhibitor. (18555228)
2008
25
Activation of Erk1/2 and Akt following unilateral ureteral obstruction. (18449171)
2008
26
Upregulation and function of GADD45gamma in unilateral ureteral obstruction. (18354378)
2008
27
Robotically assisted excision of ovarian vein for intermittent ureteral obstruction. (18435891)
2008
28
Protective effects of low-dose carbon monoxide against renal fibrosis induced by unilateral ureteral obstruction. (18094035)
2008
29
Re: Borin JF, Melamud O, Clayman RV. Initial experience with full-length metal stent to relieve malignant ureteral obstruction. J Endourol 2006;20:300-304. (18401884)
2008
30
Acute renal papillary necrosis with complete bilateral ureteral obstruction in a child. (17382173)
2007
31
Myeloid sarcoma presenting with acute renal failure and bilateral ureteral obstruction: a case report and review of the literature. (17700206)
2007
32
Scintigraphic demonstration of urine extravasation secondary to acute ureteral obstruction: a case report and some considerations about acute ureteral obstruction. (17619724)
2006
33
Osteopontin regulates renal apoptosis and interstitial fibrosis in neonatal chronic unilateral ureteral obstruction. (17003824)
2006
34
Apoptosis of circulating lymphocyte in rats with unilateral ureteral obstruction: role of angiotensin II. (16221096)
2005
35
An unusual cause of ureteral obstruction in a renal transplant recipient: ureteric aspergilloma. (15964354)
2005
36
The effect of partial unilateral ureteral obstruction release and allopurinol on the renal malondialdehyde and glutathione levels. (16351656)
2005
37
Activation of ERK in renal fibrosis after unilateral ureteral obstruction: modulation by antioxidants. (15698432)
2005
38
Validation of quantitative BOLD MRI measurements in kidney: application to unilateral ureteral obstruction. (15882272)
2005
39
Images in clinical medicine. Ureteral obstruction in pregnancy. (15483272)
2004
40
Percutaneous nephrostomy versus indwelling ureteral stents in the management of extrinsic ureteral obstruction in advanced malignancies: are there differences? (15533473)
2004
41
Diagnosis of ureteral obstruction in patients with compromised renal function: the role of noninvasive imaging modalities. (15126809)
2004
42
An unusual cause of complete distal ureteral obstruction: giant fibroepithelial polyp. (15547846)
2004
43
Effects of mycophenolate mofetil on renal interstitial fibrosis after Unilateral ureteral obstruction in rats. (14526430)
2003
44
Ureteral obstruction and reconstruction in pelvic actinomycosis. (12559308)
2003
45
Extensive retroperitoneal fibrosis with duodenal and ureteral obstruction associated with giant inflammatory aneurysm of the abdominal aorta. (14677743)
2003
46
Late post-reimplantation ureteral obstruction during pregnancy: a transient phenomenon? (12913713)
2003
47
Recoverability of renal function after relief of acute complete ureteral obstruction: clinical prospective study of the role of renal resistive index. (11927300)
2002
48
Anuria due to bilateral ureteral obstruction by Aspergillus flavus in an adult male. (11927329)
2002
49
Lower pole ureteral obstruction secondary to fecal impaction in an 8-year-old girl. (11763494)
2001
50
Xanthogranulomatous pyelonephritis with bilharzial ureteric obstruction. (6653472)
1983

Variations for Ureteral Obstruction

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Expression for genes affiliated with Ureteral Obstruction

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Expression patterns in normal tissues for genes affiliated with Ureteral Obstruction

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Pathways for genes affiliated with Ureteral Obstruction

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Compounds for genes affiliated with Ureteral Obstruction

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Compounds related to Ureteral Obstruction according to GeneCards/GeneDecks:

(show top 50)    (show all 56)
idCompoundScoreTop Affiliating Genes
1enalapril44 50 1111.9BMP7, AGTR1
2irbesartan44 28 50 1112.9PTGS1, AGTR1
3carvedilol44 50 28 1112.8AGTR1, PTGS1
48-isoprostane449.8PTGS1, AGTR1
5aminoguanidine44 28 1111.7AGTR1, CLU
6pirfenidone44 6110.6BMP7, TGFB1
7acetaminophen44 2 50 24 1113.6PTGS1, AGTR1
8alginate449.6BMP7, TGFB1
9benazepril44 50 1111.6AGTR1, TGFB1
10gm-csf44 2810.5TGFB1, PTGS1
11ramipril44 1110.5TGFB1, AGTR1
12perindopril44 50 1111.5AGTR1, TGFB1
13ns 39844 6110.5TGFB1, PTGS1
14ang ii449.4AGTR1, TGFB1
15thromboxane a244 2410.4AGTR1, PTGS1
16methacholine44 50 1111.4AGTR1, TGFB1
17deoxyribonucleic acid449.4CLU, BMP7, AGTR1
18clonidine44 50 28 1112.3AGTR1, TGFB1
19ethanol44 50 24 1112.3AGTR1, BMP7, CLU
204-hydroxytamoxifen449.2CLU, TGFB1
21tgf beta1449.1TGFB1, BMP7, AGTR1
22losartan44 50 28 1112.1TGFB1, AGTR1
23candesartan44 50 28 1112.1AGTR1, TGFB1, PTGS1
24sodium nitroprusside449.1PTGS1, TGFB1, AGTR1
25rosiglitazone28 44 50 24 1113.1AGTR1, TGFB1, PTGS1
26heparin44 28 24 1112.1CLU, BMP7, AGTR1
27pge2449.1BMP7, TGFB1, PTGS1
28aspirin44 50 28 2412.1AGTR1, TGFB1, PTGS1
29agarose449.0BMP7, CLU, TGFB1
30calcitriol44 61 24 1112.0TGFB1, CLU, BMP7
311,25 dihydroxy vitamin d3449.0CLU, TGFB1
32ribonucleic acid449.0TGFB1, CLU, BMP7
33h2o2449.0AGTR1, CLU, PTGS1
34etoposide44 50 61 1112.0CLU, TGFB1, PTGS1
35creatinine448.9AGTR1, BMP7, TGFB1
36paraffin448.9CLU, TGFB1, PTGS1
37thymidine44 249.9BMP7, CLU, TGFB1
38butyrate448.9CLU, TGFB1, DCXR
39tamoxifen44 50 28 1111.9AGTR1, CLU, TGFB1
40lactate448.9PTGS1, TGFB1, CLU
41oxygen44 249.9PTGS1, CLU, BMP7, AGTR1
42cisplatin44 50 61 1111.8TGFB1, CLU, AGTR1
43kainate44 289.7CLU, TGFB1
44actinomycin d448.5AGTR1, CLU, TGFB1, PTGS1
45vitamin d448.1AGTR1, BMP7, CLU, TGFB1, PTGS1
46cycloheximide448.1PTGS1, TGFB1, CLU, BMP7, AGTR1
47dexamethasone44 50 28 1111.1PTGS1, TGFB1, CLU, BMP7, AGTR1
48vegf448.1PTGS1, TGFB1, CLU, BMP7, AGTR1
49estrogen448.1AGTR1, BMP7, CLU, TGFB1, PTGS1
50serine448.1PTGS1, TGFB1, CLU, BMP7, AGTR1

GO Terms for genes affiliated with Ureteral Obstruction

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Cellular components related to Ureteral Obstruction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1microvillusGO:0059029.0TGFB1, DCXR
2blood microparticleGO:0725629.0CLU, TGFB1
3platelet alpha granule lumenGO:0310938.7CLU, TGFB1

Biological processes related to Ureteral Obstruction according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of peptidyl-threonine phosphorylationGO:0108009.5BMP7, TGFB1
2response to vitamin DGO:0332809.5BMP7, TGFB1
3positive regulation of pathway-restricted SMAD protein phosphorylationGO:0108629.5TGFB1, BMP7
4positive regulation of bone mineralizationGO:0305019.4BMP7, TGFB1
5epithelial to mesenchymal transitionGO:0018379.4TGFB1, BMP7
6positive regulation of cellular protein metabolic processGO:0322709.4AGTR1, TGFB1
7regulation of cell proliferationGO:0421279.4AGTR1, PTGS1
8ureteric bud developmentGO:0016579.4BMP7, TGFB1
9negative regulation of cell cycleGO:0457869.4BMP7, TGFB1
10response to estradiolGO:0323559.3BMP7, TGFB1
11lipid metabolic processGO:0066299.1CLU, PTGS1
12platelet degranulationGO:0025769.0TGFB1, CLU
13positive regulation of NF-kappaB transcription factor activityGO:0510929.0CLU, TGFB1
14positive regulation of apoptotic processGO:0430658.8BMP7, CLU, TGFB1

Products for genes affiliated with Ureteral Obstruction

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Sources for Ureteral Obstruction

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet