MCID: URT010
MIFTS: 47

Ureteral Obstruction malady

Nephrological diseases category

Summaries for Ureteral Obstruction

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34MalaCards
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MalaCards: Ureteral Obstruction is related to renal fibrosis and familial adenomatous polyposis. An important gene associated with Ureteral Obstruction is BMP7 (bone morphogenetic protein 7), and among its related pathways are TGF-beta Signaling Pathway and SMAD Signaling Network. The compounds enalapril and irbesartan have been mentioned in the context of this disorder. Affiliated tissues include kidney, bone and bone marrow, and related mouse phenotypes are immune system and renal/urinary system.

Aliases & Classifications for Ureteral Obstruction

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Sources:
9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 59SNOMED-CT, 28ICD9CM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological diseases


Aliases & Descriptions:

ureteral obstruction 9 11 46


External Ids:

Disease Ontology9 DOID:5199
SNOMED-CT59 197807001
ICD9CM28 593.4

Related Diseases for Ureteral Obstruction

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18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Ureteral Obstruction:



Diseases related to ureteral obstruction

Symptoms for Ureteral Obstruction

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Drugs & Therapeutics for Ureteral Obstruction

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Ureteral Obstruction

Drug clinical trials:

Search ClinicalTrials for Ureteral Obstruction

Search NIH Clinical Center for Ureteral Obstruction

Search CenterWatch for Ureteral Obstruction

Genetic Tests for Ureteral Obstruction

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Anatomical Context for Ureteral Obstruction

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34MalaCards
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MalaCards organs/tissues related to Ureteral Obstruction:

34
Kidney, Bone, Bone marrow, Colon, Endothelial, Monocytes, Prostate, Myeloid, Liver, Breast, Smooth muscle, Lymph node, Uterus, Cortex

Animal Models for Ureteral Obstruction or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Ureteral Obstruction:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053877.6AGTR1, BMP7, CLU, TGFB1, PTGS1
2MP:00053677.5AGTR1, BMP7, CLU, TGFB1, PTGS1
3MP:00053857.3PTGS1, TGFB1, CLU, BMP7, AGTR1

Publications for Ureteral Obstruction

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53PubMed
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Articles related to Ureteral Obstruction:

(show top 50)    (show all 547)
idTitleAuthorsYear
1
ROS dependence of cyclooxygenase-2 induction in rats subjected to unilateral ureteral obstruction. (24226522)
2014
2
Metallic Ureteral Stents in Malignant Ureteral Obstruction: Clinical Factors Predicting Stent Failure. (24397490)
2014
3
The effect of carvedilol on serum and tissue oxidative stress parameters in partial ureteral obstruction induced rat model. (23257252)
2013
4
Ulinastatin inhibits unilateral ureteral obstruction-induced renal interstitial fibrosis in rats via transforming growth factor I^ (TGF-I^)/Smad signalling pathways. (23318600)
2013
5
Five-year experience with metallic stents for chronic ureteral obstruction. (23485505)
2013
6
The protective effects of metyrosine, lacidipine, clonidine, and moxonidine on kidney damage induced by unilateral ureteral obstruction in rats. (22202971)
2012
7
Commentary to 'Ureteral obstruction following injection of dextranomer/hyaluronic acid copolymer: an infrequent but relevant complication'. (22056308)
2012
8
Gene expression changes induced by unilateral ureteral obstruction in mice. (22819101)
2012
9
Dermatan sulfate reduces monocyte chemoattractant protein 1 and TGF-I^ production, as well as macrophage recruitment and myofibroblast accumulation in mice with unilateral ureteral obstruction. (21833458)
2011
10
Vitamin E ameliorates renal fibrosis in ureteral obstruction: role of maintaining BMP-7 during epithelial-to-mesenchymal transition. (22619901)
2011
11
Renal parenchymal fibrosis and atrophy are not correlated with upper tract dilatation: long-term study of partial unilateral ureteral obstruction in neonatal mice. (21527217)
2011
12
Editorial comment on: Ureteral obstruction: is the full metallic double-pigtail stent the way to go? (19232818)
2010
13
Postpartum ovarian vein thrombosis presenting as ureteral obstruction. (22767678)
2010
14
Fucosylated chondroitin sulfate attenuates renal fibrosis in animals submitted to unilateral ureteral obstruction: a P-selectin-mediated event? (20861075)
2010
15
Nephrocutaneous bypass in ureteral obstruction. (20156649)
2010
16
Renal uptakes of 99mTc-MAG3, 99mTc-DTPA, and 99mTc-DMSA in rabbits with unilateral ureteral obstruction. (20363984)
2010
17
Noninvasive assessment of acute ureteral obstruction with diffusion-weighted MR imaging: a prospective study. (19567650)
2009
18
Melatonin attenuates unilateral ureteral obstruction-induced renal injury by reducing oxidative stress, iNOS, MAPK, and NF-kB expression. (19530942)
2009
19
Atorvastatin ameliorates tubulointerstitial fibrosis and protects renal function in chronic partial ureteral obstruction cases. (19692013)
2009
20
Evaluation of urothelial stretch-induced cyclooxygenase-2 expression in a mouse ureteral obstruction model. (19193137)
2009
21
Endoscopic management of a ureteral obstruction caused by endometriosis: a case report. (19502140)
2009
22
Persistent bilateral ureteral obstruction secondary to endometriosis despite treatment with an aromatase inhibitor. (18555228)
2008
23
Activation of Erk1/2 and Akt following unilateral ureteral obstruction. (18449171)
2008
24
Upregulation and function of GADD45gamma in unilateral ureteral obstruction. (18354378)
2008
25
Robotically assisted excision of ovarian vein for intermittent ureteral obstruction. (18435891)
2008
26
Protective effects of low-dose carbon monoxide against renal fibrosis induced by unilateral ureteral obstruction. (18094035)
2008
27
Re: Borin JF, Melamud O, Clayman RV. Initial experience with full-length metal stent to relieve malignant ureteral obstruction. J Endourol 2006;20:300-304. (18401884)
2008
28
Malignant extrinsic ureteral obstruction: a survey of urologists and medical oncologists regarding treatment patterns and preferences. (18372019)
2008
29
Acute renal papillary necrosis with complete bilateral ureteral obstruction in a child. (17382173)
2007
30
Myeloid sarcoma presenting with acute renal failure and bilateral ureteral obstruction: a case report and review of the literature. (17700206)
2007
31
Scintigraphic demonstration of urine extravasation secondary to acute ureteral obstruction: a case report and some considerations about acute ureteral obstruction. (17619724)
2006
32
Osteopontin regulates renal apoptosis and interstitial fibrosis in neonatal chronic unilateral ureteral obstruction. (17003824)
2006
33
Apoptosis of circulating lymphocyte in rats with unilateral ureteral obstruction: role of angiotensin II. (16221096)
2005
34
An unusual cause of ureteral obstruction in a renal transplant recipient: ureteric aspergilloma. (15964354)
2005
35
The effect of partial unilateral ureteral obstruction release and allopurinol on the renal malondialdehyde and glutathione levels. (16351656)
2005
36
Activation of ERK in renal fibrosis after unilateral ureteral obstruction: modulation by antioxidants. (15698432)
2005
37
Validation of quantitative BOLD MRI measurements in kidney: application to unilateral ureteral obstruction. (15882272)
2005
38
Images in clinical medicine. Ureteral obstruction in pregnancy. (15483272)
2004
39
Percutaneous nephrostomy versus indwelling ureteral stents in the management of extrinsic ureteral obstruction in advanced malignancies: are there differences? (15533473)
2004
40
Diagnosis of ureteral obstruction in patients with compromised renal function: the role of noninvasive imaging modalities. (15126809)
2004
41
An unusual cause of complete distal ureteral obstruction: giant fibroepithelial polyp. (15547846)
2004
42
Suppression of 15-hydroxyprostaglandin dehydrogenase messenger RNA concentration, protein expression, and enzymatic activity during human ureteral obstruction. (14718596)
2004
43
Effects of mycophenolate mofetil on renal interstitial fibrosis after Unilateral ureteral obstruction in rats. (14526430)
2003
44
Ureteral obstruction and reconstruction in pelvic actinomycosis. (12559308)
2003
45
Extensive retroperitoneal fibrosis with duodenal and ureteral obstruction associated with giant inflammatory aneurysm of the abdominal aorta. (14677743)
2003
46
Late post-reimplantation ureteral obstruction during pregnancy: a transient phenomenon? (12913713)
2003
47
Recoverability of renal function after relief of acute complete ureteral obstruction: clinical prospective study of the role of renal resistive index. (11927300)
2002
48
Anuria due to bilateral ureteral obstruction by Aspergillus flavus in an adult male. (11927329)
2002
49
Lower pole ureteral obstruction secondary to fecal impaction in an 8-year-old girl. (11763494)
2001
50
Xanthogranulomatous pyelonephritis with bilharzial ureteric obstruction. (6653472)
1983

Variations for Ureteral Obstruction

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Expression for genes affiliated with Ureteral Obstruction

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Ureteral Obstruction

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Pathways for genes affiliated with Ureteral Obstruction

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Sources:
51PathCards, 58SinoBiological, 54QIAGEN, 39NCBI BioSystems Database, 31KEGG, 56Reactome, 52PharmGKB
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Compounds for genes affiliated with Ureteral Obstruction

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Sources:
46Novoseek, 52PharmGKB, 12DrugBank, 30IUPHAR, 62Tocris Bioscience, 3BitterDB, 25HMDB
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Compounds related to Ureteral Obstruction according to GeneCards/GeneDecks:

(show top 50)    (show all 56)
idCompoundScoreTop Affiliating Genes
1enalapril46 52 1211.9BMP7, AGTR1
2irbesartan46 30 52 1212.9PTGS1, AGTR1
3carvedilol46 52 30 1212.8AGTR1, PTGS1
48-isoprostane469.8PTGS1, AGTR1
5aminoguanidine46 30 1211.7AGTR1, CLU
6pirfenidone46 6210.6BMP7, TGFB1
7acetaminophen46 3 52 25 1213.6PTGS1, AGTR1
8alginate469.6BMP7, TGFB1
9benazepril46 52 1211.6AGTR1, TGFB1
10gm-csf46 3010.5TGFB1, PTGS1
11ramipril46 1210.5TGFB1, AGTR1
12perindopril46 52 1211.5AGTR1, TGFB1
13ns 39846 6210.5TGFB1, PTGS1
14ang ii469.4AGTR1, TGFB1
15thromboxane a246 2510.4AGTR1, PTGS1
16methacholine46 52 1211.4AGTR1, TGFB1
17deoxyribonucleic acid469.4CLU, BMP7, AGTR1
18clonidine46 52 30 1212.3AGTR1, TGFB1
19ethanol46 52 25 1212.3AGTR1, BMP7, CLU
204-hydroxytamoxifen469.2CLU, TGFB1
21tgf beta1469.1TGFB1, BMP7, AGTR1
22losartan46 52 30 1212.1TGFB1, AGTR1
23candesartan46 52 30 1212.1AGTR1, TGFB1, PTGS1
24sodium nitroprusside469.1PTGS1, TGFB1, AGTR1
25rosiglitazone30 46 52 25 1213.1AGTR1, TGFB1, PTGS1
26heparin46 30 25 1212.1CLU, BMP7, AGTR1
27pge2469.1BMP7, TGFB1, PTGS1
28aspirin46 52 30 2512.1AGTR1, TGFB1, PTGS1
29agarose469.0BMP7, CLU, TGFB1
30calcitriol46 62 25 1212.0TGFB1, CLU, BMP7
311,25 dihydroxy vitamin d3469.0CLU, TGFB1
32ribonucleic acid469.0TGFB1, CLU, BMP7
33h2o2469.0AGTR1, CLU, PTGS1
34etoposide46 52 62 1212.0CLU, TGFB1, PTGS1
35creatinine468.9AGTR1, BMP7, TGFB1
36paraffin468.9CLU, TGFB1, PTGS1
37thymidine46 259.9BMP7, CLU, TGFB1
38butyrate468.9CLU, TGFB1, DCXR
39tamoxifen46 52 30 1211.9AGTR1, CLU, TGFB1
40lactate468.9PTGS1, TGFB1, CLU
41oxygen46 259.9PTGS1, CLU, BMP7, AGTR1
42cisplatin46 52 62 1211.8TGFB1, CLU, AGTR1
43kainate46 309.7CLU, TGFB1
44actinomycin d468.5AGTR1, CLU, TGFB1, PTGS1
45vitamin d468.1AGTR1, BMP7, CLU, TGFB1, PTGS1
46cycloheximide468.1PTGS1, TGFB1, CLU, BMP7, AGTR1
47dexamethasone46 52 30 1211.1PTGS1, TGFB1, CLU, BMP7, AGTR1
48vegf468.1PTGS1, TGFB1, CLU, BMP7, AGTR1
49estrogen468.1AGTR1, BMP7, CLU, TGFB1, PTGS1
50serine468.1PTGS1, TGFB1, CLU, BMP7, AGTR1

GO Terms for genes affiliated with Ureteral Obstruction

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17Gene Ontology
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Cellular components related to Ureteral Obstruction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1microvillusGO:0059029.0TGFB1, DCXR
2blood microparticleGO:0725629.0CLU, TGFB1
3platelet alpha granule lumenGO:0310938.7CLU, TGFB1

Biological processes related to Ureteral Obstruction according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of peptidyl-threonine phosphorylationGO:0108009.5BMP7, TGFB1
2response to vitamin DGO:0332809.5BMP7, TGFB1
3positive regulation of pathway-restricted SMAD protein phosphorylationGO:0108629.5TGFB1, BMP7
4positive regulation of bone mineralizationGO:0305019.4BMP7, TGFB1
5epithelial to mesenchymal transitionGO:0018379.4TGFB1, BMP7
6positive regulation of cellular protein metabolic processGO:0322709.4AGTR1, TGFB1
7regulation of cell proliferationGO:0421279.4AGTR1, PTGS1
8ureteric bud developmentGO:0016579.4BMP7, TGFB1
9negative regulation of cell cycleGO:0457869.4BMP7, TGFB1
10response to estradiolGO:0323559.3BMP7, TGFB1
11lipid metabolic processGO:0066299.1CLU, PTGS1
12platelet degranulationGO:0025769.0TGFB1, CLU
13positive regulation of NF-kappaB transcription factor activityGO:0510929.0CLU, TGFB1
14positive regulation of apoptotic processGO:0430658.8BMP7, CLU, TGFB1

Products for genes affiliated with Ureteral Obstruction

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Sources for Ureteral Obstruction

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet