MCID: URT010
MIFTS: 49

Ureteral Obstruction malady

Summaries for Ureteral Obstruction

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32MalaCards
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MalaCards: Ureteral Obstruction is related to hydronephrosis and vesicoureteral reflux. An important gene associated with Ureteral Obstruction is PTGS1 (prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)), and among its related pathways are p70S6K Signaling and Passive Transport by Aquaporins. The compounds angiotensin iii and angiotensin i have been mentioned in the context of this disorder. Affiliated tissues include kidney, bone and bone marrow, and related mouse phenotypes are integument and reproductive system.

Aliases & Classifications for Ureteral Obstruction

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8Disease Ontology, 10DISEASES, 44Novoseek, 27ICD9CM, 60UMLS, 56SNOMED-CT
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Aliases & Descriptions:

ureteral obstruction 8 10 44


External Ids:

Disease Ontology8 DOID:5199
SNOMED-CT56 197807001
ICD9CM27 593.4

Related Diseases for Ureteral Obstruction

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17GeneCards, 18GeneDecks
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Diseases related to Ureteral Obstruction via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 118)
idRelated DiseaseScoreTop Affiliating Genes
1hydronephrosis30.8AGTR2
2vesicoureteral reflux30.6AGTR1, AGTR2, AMBP
3ureteral disease30.5BMP7, AQP3, AQP2, TGFB1
4hypertension30.3TGFB1, AGTR1
5ischemia30.3CLU, AGTR2, BMP7
6pancreatitis30.2TGFB1
7diabetes insipidus30.2AQP2
8nephrogenic diabetes insipidus30.2AQP2, AQP3
9glomerulonephritis30.0AMBP, AGTR1, CLU, TGFB1
10adenoma30.0PTGS1, HPGD, AGTR2, FABP1
11prostate cancer30.0TGFB1, PTGS1, CLU, BMP7
12adenocarcinoma30.0AMBP, PDGFA, AGTR1, CLU, PTGS1, AQP3
13anuria10.5
14endometriosis10.4
15pelvic lipomatosis10.4
16lipomatosis10.4
17aortic aneurysm10.3
18renal artery obstruction10.2
19abdominal aortic aneurysm10.2
20perinephritis10.2
21aortitis10.2
22amyloidosis10.2
23cervicitis10.2
24osteomyelitis10.2
25prostatitis10.2
26pyelonephritis10.2
27schistosomiasis10.2
28vaginitis10.2
29nephrogenic adenoma10.0
30corpus luteum cyst10.0
31discitis10.0
32acute pancreatitis10.0
33myoma10.0
34cystitis cystica10.0
35xanthogranulomatous pyelonephritis10.0
36renal agenesis10.0
37erdheim-chester disease10.0
38chronic granulomatous disease10.0
39henoch-schoenlein purpura10.0
40familial adenomatous polyposis10.0
41low compliance bladder10.0
42immune-complex glomerulonephritis10.0
43nephrolithiasis10.0
44actinomycosis10.0
45myeloid sarcoma10.0
46duodenitis10.0
47ureteral lymphoma10.0
48ureterolithiasis10.0
49lymphoplasmacytic lymphoma10.0
50retroperitoneal lymphoma10.0

Graphical network of the top 20 diseases related to Ureteral Obstruction:



Diseases related to ureteral obstruction

Clinical Features for Ureteral Obstruction

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Drugs & Therapeutics for Ureteral Obstruction

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Ureteral Obstruction

Drug clinical trials:

Search ClinicalTrials for Ureteral Obstruction

Search NIH Clinical Center for Ureteral Obstruction

Search CenterWatch for Ureteral Obstruction

Genetic Tests for Ureteral Obstruction

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Anatomical Context for Ureteral Obstruction

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32MalaCards
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MalaCards organs/tissues related to Ureteral Obstruction:

32
Kidney, Bone, Bone marrow, Monocytes, Endothelial, Colon, Smooth muscle, Prostate, Myeloid, Liver, Cortex, Breast, Uterus, Lymph node

Animal Models for Ureteral Obstruction or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Ureteral Obstruction:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107719.8TGFB1, AQP2, CLK1, AGTR2, BMP7, PDGFA
2MP:00053899.8AMBP, SFRP4, PDGFA, PTGS1, ADAMTS1, AQP2
3MP:00053859.6SFRP4, PDGFA, BMP7, AGTR2, AGTR1, HPGD
4MP:00053679.5TGFB1, SFRP4, PDGFA, BMP7, AGTR2, AGTR1
5MP:00053799.5AMBP, BMP7, AGTR2, HPGD, PTGS1, ADAMTS1
6MP:00053789.3SFRP4, PDGFA, BMP7, AGTR2, AGTR1, CLK1
7MP:00107689.1AGTR1, AGTR2, BMP7, PDGFA, SFRP4, MAP3K12
8MP:00053769.1MAP3K12, AGTR1, AGTR2, FABP1, PDGFA, SFRP4

Publications for Ureteral Obstruction

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50PubMed
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Articles related to Ureteral Obstruction:

(show top 50)    (show all 586)
idTitleAuthorsYear
1
Five-year experience with metallic stents for chronic ureteral obstruction. (23485505)
2013
2
Defect in Runx2 gene accelerates ureteral obstruction-induced kidney fibrosis via increased TGF-I^ signaling pathway. (23639629)
2013
3
Asiatic acid ameliorates tubulointerstitial fibrosis in mice with ureteral obstruction. (24137256)
2013
4
The protective effects of metyrosine, lacidipine, clonidine, and moxonidine on kidney damage induced by unilateral ureteral obstruction in rats. (22202971)
2012
5
Effect of lisinopril on renal tissue damage in unilateral ureteral obstruction in rats. (21667191)
2012
6
Interleukin-1 accounts for intrarenal Th17 cell activation during ureteral obstruction. (21975862)
2012
7
Variable partial unilateral ureteral obstruction and its release in the neonatal and adult mouse. (22639278)
2012
8
Association of PAX2 with cell apoptosis in unilateral ureteral obstruction rats. (22229793)
2012
9
The role of apelin on the alleviative effect of Angiotensin receptor blocker in unilateral ureteral obstruction-induced renal fibrosis. (22619666)
2012
10
Bilateral ureteral obstruction in a cat due to a ureteral transitional cell carcinoma. (23115367)
2012
11
Taxol and taurine protect the renal tissue of rats after unilateral ureteral obstruction: a stereological survey. (22670197)
2012
12
Dermatan sulfate reduces monocyte chemoattractant protein 1 and TGF-I^ production, as well as macrophage recruitment and myofibroblast accumulation in mice with unilateral ureteral obstruction. (21833458)
2011
13
Prevention of renal interstitial fibrosis via histone deacetylase inhibition in rats with unilateral ureteral obstruction. (20206695)
2010
14
Adrenomedullin increases renal nitric oxide production and ameliorates renal injury in mice with unilateral ureteral obstruction. (20172553)
2010
15
Role of percutaneous nephrostomy (PCN) in malignant ureteral obstruction. (20419970)
2010
16
LSKL, a peptide antagonist of thrombospondin-1, attenuates renal interstitial fibrosis in rats with unilateral ureteral obstruction. (20195829)
2010
17
Inducible nitric oxide synthase modulates hydronephrosis following partial or complete unilateral ureteral obstruction in the neonatal mouse. (19889956)
2010
18
Transplantation of endothelial progenitor cells alleviates renal interstitial fibrosis in a mouse model of unilateral ureteral obstruction. (20331991)
2010
19
Noninvasive assessment of acute ureteral obstruction with diffusion-weighted MR imaging: a prospective study. (19567650)
2009
20
Endoscopic management of a ureteral obstruction caused by endometriosis: a case report. (19502140)
2009
21
Long-term EGF treatment partially prevents reduction of renal blood flow in response to neonatally induced partial unilateral ureteral obstruction. (19142026)
2009
22
Bone marrow mononuclear cells attenuate interstitial fibrosis and stimulate the repair of tubular epithelial cells after unilateral ureteral obstruction. (19910699)
2009
23
Erythropoietin attenuates renal injury in an experimental model of rat unilateral ureteral obstruction via anti-inflammatory and anti-apoptotic effects. (19157461)
2009
24
Deletion of the Met receptor in the collecting duct decreases renal repair following ureteral obstruction. (19675527)
2009
25
Mast cells decrease renal fibrosis in unilateral ureteral obstruction. (19242503)
2009
26
Ureteral metal stents: 10-year experience with malignant ureteral obstruction treatment. (19836807)
2009
27
The undoing of ureteral obstruction from malignancy-who and how? (18550096)
2008
28
Robotic ureterolysis, retroperitoneal biopsy, and omental wrap for the treatment of ureteral obstruction due to idiopathic retroperitoneal fibrosis. (17192802)
2006
29
Initial experience with full-length metal stent to relieve malignant ureteral obstruction. (16724898)
2006
30
Non-invasive evaluation of bilateral renal regional blood flow and tubular dynamics during acute unilateral ureteral obstruction. (15632349)
2005
31
Bilateral ureteral obstruction after appendicectomy. (15789795)
2005
32
Altered expression of urea transporters in response to ureteral obstruction. (14982816)
2004
33
Chemokine receptor CCR1 but not CCR5 mediates leukocyte recruitment and subsequent renal fibrosis after unilateral ureteral obstruction. (14747380)
2004
34
Unusual causes of ureteral obstruction in renal allografts: case reports. (12591429)
2003
35
Prevention of kidney ischemia/reperfusion-induced functional injury, MAPK and MAPK kinase activation, and inflammation by remote transient ureteral obstruction. (11696540)
2002
36
Acute ureteral obstruction following transvaginal oocyte retrieval for IVF. (11756377)
2002
37
Lower pole ureteral obstruction secondary to fecal impaction in an 8-year-old girl. (11763494)
2001
38
Diminished renal expression of aquaporin water channels in rats with experimental bilateral ureteral obstruction. (11562400)
2001
39
Partial ureteral obstruction dysregulates the renal renin-angiotensin system in the fetal sheep kidney. (11489731)
2001
40
Osteogenic protein-1 prevents renal fibrogenesis associated with ureteral obstruction. (10894795)
2000
41
A case of ureteric obstruction, retroperitoneal fibrosis, and carcinoid tumour. (10396587)
1999
42
Ureteral obstruction reverses glomerular proliferation in immune complex glomerulonephritis. (10072261)
1999
43
Point of technique: Ureterocalycostomy in the management of pelvi-ureteric junction obstruction in the horseshoe kidney. (10468740)
1999
44
Control of p53 and p21 (WAF1) expression during unilateral ureteral obstruction. (8941927)
1996
45
Ureteric obstruction due to an infected urachal cyst. (7663929)
1995
46
Chronic salpingo-oAPphoritis with hydrosalpinx formation and ureteric obstruction: A case report. (550377)
1979
47
Pelvic lipomatosis presenting as acute ureteric obstruction. (990689)
1976
48
Ureteral obstruction caused by hemorrhagic corpus luteum cyst. (4836342)
1974
49
Two autopsy cases of congenital hydronephrosis due to ureteral obstruction. (5536770)
1970
50
Hysterectomy in the presence of peritonitis, salpingitis and ureteral obstruction. (20248166)
1947

Genetic Variations for Ureteral Obstruction

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Expression for genes affiliated with Ureteral Obstruction

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Ureteral Obstruction

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Pathways for genes affiliated with Ureteral Obstruction

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51QIAGEN, 53Reactome, 49PharmGKB, 37NCBI BioSystems Database
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Compounds for genes affiliated with Ureteral Obstruction

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28IUPHAR, 44Novoseek, 11DrugBank, 49PharmGKB, 59Tocris Bioscience, 24HMDB
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Compounds related to Ureteral Obstruction according to GeneCards/GeneDecks:

(show all 50)
idCompoundScoreTop Affiliating Genes
1angiotensin iii2810.7AGTR2, AGTR1
2angiotensin i2810.7AGTR2, AGTR1
3etoperidone4410.7AGTR2, AGTR1
413,14-dihydro-15-keto-pge24410.7HPGD, PTGS1
5Tasosartan1110.7AGTR1, AGTR2
6cgp42112a4410.6AGTR1, AGTR2
7pge24410.6AQP2, TGFB1
8irbesartan44 28 49 1113.6PTGS1, AGTR1, AGTR2
9cyclosporin a44 28 5912.6AQP2, AMBP
10saralasin4410.6AGTR1, AGTR2
11candesartan44 28 1112.6AGTR2, AGTR1, PTGS1, TGFB1
12angiotensin ii28 2411.6AGTR1, AGTR2
13ang ii4410.6AGTR2, AGTR1, TGFB1
14mercury4410.6AMBP, AQP3, AQP2
15deoxyribonucleic acid4410.5BMP7, AGTR1, CLU
16benazepril44 1111.5TGFB1, AGTR1
17enalapril44 49 1112.5AGTR1, AGTR2, BMP7, AMBP
18losartan44 49 28 1113.5TGFB1, AGTR1, AGTR2, PDGFA
19pd12331944 2811.5AGTR2, AGTR1
20hgcl24410.5AQP2, AQP3
21agarose4410.5AMBP, BMP7, CLU, TGFB1
22hg2+2810.4AQP3, AQP2
23tgf beta14410.4PDGFA, BMP7, AGTR1, ADAMTS1, TGFB1
24ribonucleic acid4410.4PDGFA, BMP7, HPGD, CLU, TGFB1
25ethanol44 49 11 2413.4FABP1, BMP7, AGTR2, AGTR1, CLU
26calcitriol44 59 11 2413.4SFRP4, BMP7, HPGD, CLU, TGFB1
27arachidonic acid44 28 11 2413.4PTGS1, HPGD, AGTR1, AGTR2, FABP1
28inulin4410.3AMBP, CLU
29prostaglandin4410.3AMBP, AGTR2, AGTR1, HPGD, PTGS1, AQP2
30cisplatin44 49 59 1113.3AMBP, AGTR1, CLU, AQP2, TGFB1
31vitamin d4410.3PDGFA, BMP7, AGTR1, HPGD, CLU, PTGS1
32cycloheximide4410.3PDGFA, BMP7, AGTR2, AGTR1, CLU, PTGS1
33vegf4410.2PDGFA, FABP1, BMP7, AGTR1, CLU, PTGS1
34sodium44 2411.2AMBP, SFRP4, AGTR2, AGTR1, AQP2
35heparin44 28 11 2413.2PDGFA, BMP7, AGTR1, CLU, ADAMTS1
36sodium nitroprusside4410.2TGFB1, PTGS1, AGTR1
37indomethacin44 59 28 1113.2TGFB1, PTGS1, HPGD, AGTR2
38alanine4410.2AMBP, AGTR2, AGTR1, HPGD, PTGS1, AQP2
39threonine4410.2BMP7, MAP3K12, HPGD, AQP3, AQP2, TGFB1
40silver4410.2AQP3, AGTR1, AMBP
41progesterone44 59 28 11 2414.2SFRP4, PDGFA, BMP7, HPGD, CLU, ADAMTS1
42glucose4410.2AMBP, FABP1, BMP7, DCXR, AGTR1, AQP3
43creatinine4410.1AMBP, FABP1, BMP7, AGTR2, AGTR1, AQP3
44dexamethasone44 49 28 1113.1TGFB1, PDGFA, FABP1, BMP7, HPGD, CLU
45oxygen44 2411.1PDGFA, BMP7, AGTR2, AGTR1, CLU, PTGS1
46retinoic acid44 2411.1AMBP, PDGFA, FABP1, BMP7, MAP3K12, CLU
47methionine4410.0AMBP, FABP1, HPGD, AQP2
48calcium44 49 11 2412.9AMBP, SFRP4, PDGFA, BMP7, AGTR2, AGTR1
49serine449.8AMBP, BMP7, AGTR1, MAP3K12, HPGD, CLU
50cysteine449.6AMBP, AGTR1, HPGD, CLU, PTGS1, AQP2

GO Terms for genes affiliated with Ureteral Obstruction

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16Gene Ontology
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Cellular components related to Ureteral Obstruction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1microvillusGO:00590210.1TGFB1, DCXR, PDGFA
2platelet alpha granule lumenGO:0310939.9TGFB1, CLU, PDGFA
3extracellular spaceGO:0056159.8SFRP4, PDGFA, BMP7, CLU, TGFB1, AMBP

Biological processes related to Ureteral Obstruction according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1renin-angiotensin regulation of aldosterone productionGO:00201810.5AGTR1, AGTR2
2cellular response to dexamethasone stimulusGO:07154910.5AGTR2, TGFB1
3negative regulation of immune responseGO:05077710.5TGFB1, AMBP
4negative regulation of cell cycleGO:04578610.4BMP7, HPGD, TGFB1
5positive regulation of cellular protein metabolic processGO:03227010.4TGFB1, AGTR1
6platelet degranulationGO:00257610.4TGFB1, CLU, PDGFA
7response to vitamin DGO:03328010.3TGFB1, AQP3
8female pregnancyGO:00756510.3TGFB1, AQP2, HPGD, AMBP
9negative regulation of blood vessel endothelial cell migrationGO:04353710.3AGTR2, TGFB1
10positive regulation of apoptotic processGO:04306510.2SFRP4, BMP7, CLU, TGFB1
11cyclooxygenase pathwayGO:01937110.2HPGD, PTGS1
12embryo developmentGO:00979010.1TGFB1, PDGFA, SFRP4
13positive regulation of peptidyl-threonine phosphorylationGO:01080010.0BMP7, TGFB1

Molecular functions related to Ureteral Obstruction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1angiotensin type II receptor activityGO:00494510.0AGTR1, AGTR2
2protein homodimerization activityGO:0428039.9TGFB1, HPGD, MAP3K12, PDGFA, AMBP

Products for genes affiliated with Ureteral Obstruction

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Sources for Ureteral Obstruction

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet