Ureteral Obstruction malady

MalaCards: Ureteral Obstruction is related to endometriosis and ischemia. An important gene associated with Ureteral Obstruction is PDGFA (platelet-derived growth factor alpha polypeptide), and among its related pathways are PPAR Pathway and Actin-Based Motility by Rho Family GTPases. The compounds bleomycin and dmso have been mentioned in the context of this disorder. Affiliated tissues include kidney, liver and myeloid, and related mouse phenotypes are embryogenesis and respiratory system.

Aliases & Descriptions:

ureteral obstruction 6 8 32 43

Diseases related to ureteral obstruction by text searches and GeneDecks gene sharing:

(show top 50)    (show all 473)

id	Related Disease	Score	Top Affiliating Genes
1	endometriosis	23.0	SFRP4, BMP6, MPO, CDKN1A, CD36, CDH1
2	ischemia	21.3	SELL, BMP7, CLU, MPO, CDKN1A, CD36
3	sarcoma	21.2	SFRP4, BMP6, BMP7, CLU, MPO, CDKN1A
4	fibrosis	21.1	SFRP4, SELL, BMP6, BMP7, CLU, S100A4
5	chronic rapidly progressive glomerulonephritis	13.7	FABP1, AMBP, AGTR1
6	vesicoureteral reflux	13.6	AMBP, AGTR1, AGTR2, TGFB1
7	conn's syndrome	13.5	NR3C2, AGTR1, AGTR2
8	ureteral disease	13.5	BMP7, CDH1, TGFB1
9	hypercalciuria	13.5	AQP2, AMBP, AGTR1, SLC12A1
10	nephrogenic diabetes insipidus	13.5	AQP2, AQP3, AGTR1, SLC12A1
11	follicular dendritic cell tumor	13.5	CLU, MPO, PTPRC
12	nephrosclerosis	13.4	BMP7, MPO, NR3C2, AGTR1, TGFB1
13	hypertensive heart disease	13.4	CD36, NR3C2, AGTR1
14	marfan syndrome	13.3	BMP6, CD36, AGTR1, TGFB1
15	androgenetic alopecia	13.3	CYP19A1, NR3C2, TGFB1
16	primary pulmonary hypertension	13.3	BMP6, BMP7, TIMP1, TGFB1
17	bullous keratopathy	13.2	CDKN1A, AQP3, TIMP1, TGFB1
18	localized scleroderma	13.2	BMP6, CD36, SMAD7, TGFB1
19	colonic neoplasm	13.2	CLU, CDKN1A, CDH1
20	nonalcoholic steatohepatitis	13.2	BMP6, MPO, AGTR1, TGFB1
21	conduction disease	13.2	CD36, TIMP1, TGFB1
22	keratopathy	13.2	CDKN1A, AQP3, TIMP1, TGFB1
23	iga glomerulonephritis	13.2	SELL, BMP6, SMAD2, AGTR1, TGFB1
24	diabetes insipidus	13.2	MPO, AQP2, AQP3, GNRH1, AGTR1, SLC12A1
25	erythrocytosis	13.2	AGTR1, AGTR2, TIMP1, EPO
26	barrett's adenocarcinoma	13.1	S100A4, PTGS2, PTGS1, TGFB1
27	thyroid cancer, anaplastic	13.1	BMP7, S100A4, CDKN1A, CDH1, TGFB1
28	hyperlipidemia	13.1	CLU, MPO, CD36, PDGFA, AGTR1, AGTR2
29	hydronephrosis	13.1	CLU, AQP2, AMBP, AGTR2, SLC12A1, EPO
30	hereditary pancreatitis	13.1	CLU, S100A4, CD36, TGFB1
31	pyelonephritis	13.1	AQP2, AMBP, TIMP1, EPO
32	diastolic heart failure	13.1	BMP6, MAPK8, AGTR1
33	hemorrhagic shock and encephalopathy syndrome	13.1	MPO, NOS2, ABP1
34	vernal keratoconjunctivitis	13.1	CD36, SMAD2, ABP1, TIMP1, TGFB1
35	pilocytic astrocytoma	13.1	S100A4, CDKN1A, PDGFA, TIMP1
36	proliferative vitreoretinopathy	13.0	BMP6, TIMP1, TGFB1, HGF
37	hemolytic-uremic syndrome	13.0	CLU, TIMP1, TGFB1, EPO
38	congenital heart defect	13.0	CLU, MAPK14, NR3C2, AGTR1, AGTR2
39	lacrimal duct obstruction	13.0	SELL, BMP7, AQP2, AMBP, PTGS1, PTPRC
40	hepatocellular cancer	13.0	BMP6, SMAD2, TGFB1, HGF
41	deep vein thrombosis	13.0	PTGS1, ABP1, HGF, EPO
42	chorioamnionitis	13.0	BMP6, MPO, HPGD, TGFB1, EPO
43	glomerulopathy	13.0	BMP6, PTGS2, PTGS1, AGTR1, TGFB1
44	congestive heart failure	13.0	AQP2, NR3C2, AGTR1, EPO
45	severe congenital neutropenia	13.0	SELL, MPO, CYP19A1, EPO
46	usual interstitial pneumonia	13.0	IFNG, AGTR1, TGFB1
47	poems syndrome	12.9	CD36, TIMP1, EPO
48	adrenal hyperplasia	12.9	CD36, GNRH1, CYP19A1, NR3C2, AGTR1
49	gastric cardia adenocarcinoma	12.9	PTGS2, TGFB1, HGF
50	collagenous colitis	12.9	MPO, NOS2, TIMP1

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to ureteral obstruction:

²²

MGI Mouse Phenotypes related to ureteral obstruction:

²⁵ (show all 24)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	embryogenesis phenotype	MP:0005380	10.5	SMURF2
2	respiratory system phenotype	MP:0005388	10.2	PTPRC, SELL, SFRP4
3	craniofacial phenotype	MP:0005382	9.8	MAPK8, SMAD3
4	endocrine/exocrine gland phenotype	MP:0005379	9.6	ADAMTS1, HPGD, GNRH1, IFNG, SELL
5	integument phenotype	MP:0010771	9.0	SLC12A1, SMAD2, CYP19A1, PTGS1, GNRH1, IFNG
6	hematopoietic system phenotype	MP:0005397	8.9	EPO, HGF, SLC12A1, SMAD7, PTPRC, CDKN1A
7	renal/urinary system phenotype	MP:0005367	8.6	BMP7, CLU, CDKN1A, AQP2, AQP3, GNRH1
8	liver/biliary system phenotype	MP:0005370	8.6	EPO, SMAD3, SMAD2, CYP19A1, PTPRC, IFNG
9	immune system phenotype	MP:0005387	8.2	SLC12A1, AGTR1, SMAD7, SMAD2, CYP19A1, PTPRC
10	normal phenotype	MP:0002873	7.8	EPO, SMURF2, SMAD2, CYP19A1, PTPRC, HNF4A
11	adipose tissue phenotype	MP:0005375	7.6	ADAMTS1, TGFB1, AGTR2, NOS2, CYP19A1, PTGS2
12	behavior/neurological phenotype	MP:0005386	7.3	SMAD2, SMAD3, SMAD7, NOS2, AGTR2, SLC12A1
13	skeleton phenotype	MP:0005390	7.1	SLC12A1, AGTR2, PDGFA, SMAD3, SMAD2, CYP19A1
14	vision/eye phenotype	MP:0005391	6.7	SMAD2, SMAD3, NOS2, TGFB1, PTGS2, IFNG
15	reproductive system phenotype	MP:0005389	6.3	SMAD2, SMAD3, SMAD7, NOS2, PDGFA, TIMP1
16	muscle phenotype	MP:0005369	6.2	TGFB1, AGTR2, PDGFA, NOS2, SMAD7, CYP19A1
17	digestive/alimentary phenotype	MP:0005381	6.2	PTGS1, PTPRC, SMAD2, SMAD3, NOS2, AGTR2
18	mortality/aging	MP:0010768	6.0	SMAD2, SMAD3, SMAD7, SMURF2, NOS2, AGTR1
19	tumorigenesis	MP:0002006	5.9	PTPRC, SMAD2, SMAD3, NOS2, AGTR2, TIMP1
20	growth/size phenotype	MP:0005378	5.7	CDH1, HGF, SLC12A1, AGTR1, AQP2, AQP3
21	nervous system phenotype	MP:0003631	5.4	CYP19A1, NR3C2, SMAD2, SMAD3, SMURF2, NOS2
22	cellular phenotype	MP:0005384	3.6	PTPRC, CYP19A1, SMAD2, SMAD3, SMAD7, SMURF2
23	cardiovascular system phenotype	MP:0005385	3.4	SFRP4, SELL, BMP7, CLU, MPO, CDKN1A
24	homeostasis/metabolism phenotype	MP:0005376	2.8	SFRP4, HNF4A, PTGS2, PTGS1, PTPRC, CYP19A1

Articles related to ureteral obstruction:

(show all 28)

id	Title	Authors	Year	Affiliating Genes
1	Increased E-cadherin expression in the ligated kidney following unilateral ureteric obstruction. (18818685)	Docherty N.G.... Watson R.W.	2009	CDH1
2	Persistent bilateral ureteral obstruction secondary to endometriosis despite treatment with an aromatase inhibitor. (18555228)	Bohrer J.... Falcone T.	2008	CYP19A1
3	Suppression of renal alpha-dicarbonyl compounds generated following ureteral obstruction by kidney-specific alpha-dicarbonyl/L-xylulose reductase. (18079483)	Odani H.... Nakagawa J.	2008	DCXR
4	Erythropoietin and its non-erythropoietic derivative: do they ameliorate renal tubulointerstitial injury in ureteral obstruction? (18759748)	Srisawat N.... Eiam-Ong S.	2008	TGFB1, TIMP1
5	Myeloid sarcoma presenting with acute renal failure and bilateral ureteral obstruction: a case report and review of the literature. (17700206)	Usmani S.Z.... Nasser K.A.	2007	PTPRC, MPO
6	Angiotensin II type 1 receptor blockade prevents decrease in adult stem-like cells in kidney after ureteral obstruction. (17692840)	Marumo T.... Fujita T.	2007	AGTR1
7	Expression and significance of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)-1 in an animal model of renal interstitial fibrosis induced by unilateral ureteral obstruction. (17583485)	Nakamura A.... Komurasaki T.	2007	ADAMTS1
8	Erythropoietin decreases renal fibrosis in mice with ureteral obstruction: role of inhibiting TGF-beta-induced epithelial-to-mesenchymal transition. (17389738)	Park S.H.... Kim Y.L.	2007	EPO
9	Biochemical-molecular markers in unilateral ureteral obstruction. (17665634)	Manucha W.	2007	BMP6
10	Liver-type fatty acid-binding protein attenuates renal injury induced by unilateral ureteral obstruction. (17003471)	Kamijo-Ikemori A.... Kimura K.	2006	FABP1
11	Wnt-dependent beta-catenin signaling is activated after unilateral ureteral obstruction, and recombinant secreted frizzled-related protein 4 alters the progression of renal fibrosis. (15944336)	Surendran K.... Hruska K.A.	2005	HNF4A, SFRP4
12	Elevated plasma concentrations of transforming growth factor-beta 1 in patients with unilateral ureteral obstruction. (16315065)	Vuruskan H.... Oktay B.	2005	TGFB1
13	COX-2 inhibition prevents downregulation of key renal water and sodium transport proteins in response to bilateral ureteral obstruction. (15840770)	Norregaard R.... Frokiaer J.	2005	PTGS1, PTGS2, SLC12A1
14	Suppression of 15-hydroxyprostaglandin dehydrogenase messenger RNA concentration, protein expression, and enzymatic activity during human ureteral obstruction. (14718596)	Jerde T.J.... Nakada S.Y.	2004	HPGD, RPS26
15	Liposome-mediated transfer of nitric oxide synthase gene improves renal function in ureteral obstruction in rats. (15458429)	Ito K.... Felsen D.	2004	NOS2
16	Prevention of renal fibrosis by spironolactone in mice with complete unilateral ureteral obstruction. (15371767)	Trachtman H.... Palmer L.S.	2004	CD36, NR3C2
17	Angiotensin II, via AT1 and AT2 receptors and NF-kappaB pathway, regulates the inflammatory response in unilateral ureteral obstruction. (15153562)	Esteban V.... Ruiz-Ortega M.	2004	AGTR2, AGTR1
18	Prevention of kidney ischemia/reperfusion-induced functional injury, MAPK and MAPK kinase activation, and inflammation by remote transient ureteral obstruction. (11696540)	Park K.M.... Bonventre J.V.	2002	MAPK8, MAPK14, MAP3K12
19	Nitric oxide in unilateral ureteral obstruction: effe ct on regional renal blood flow. (11231361)	Hegarty N.J.... Fitzpatrick J.M.	2001	NOS2
20	H+-ATPase activity on unilateral ureteral obstruction : interaction of endogenous nitric oxide and angiotensin II. (11012898)	Valles P.G.... Manucha W.A.	2000	NOS2
21	Osteogenic protein-1 prevents renal fibrogenesis associated with ureteral obstruction. (10894795)	Hruska K.A.... Morrissey J.	2000	BMP7
22	L-selectin and its ligands mediate infiltration of mononuclear cells into kidney interstitium after ureteric obstruction. (10398147)	Shikata K.... Miyasaka M.	1999	SELL
23	Ureteral obstruction in a patient with chronic granulomatous disease, receiving combined prophylaxis with IFN-gamma and antibiotics. (9578979)	Schumacher R.F.... Ugazio A.G.	1998	IFNG
24	Polyamine oxidase and diamine oxidase activities in a cute ureteral obstruction. (9678451)	BjelakoviA8 G.... StefanoviA8 V.	1998	ABP1
25	Control of p53 and p21 (WAF1) expression during unilateral ureteral obstruction. (8941927)	Morrissey J.J.... Klahr S.	1996	CDKN1A
26	Bilateral ureteral obstruction downregulates expressi on of vasopressin-sensitive AQP-2 water channel in rat kidney. (8967344)	FrA... Nielsen S.	1996	AQP2
27	Effects of experimental ureteral obstruction on platelet-derived growth factor-A and type I procollagen expression in fetal metanephric kidneys. (7819000)	Liapis H.... Steinhardt G.	1994	PDGFA
28	Leuprolide acetate in the management of ureteral obstruction caused by endometriosis. (2106110)	Rivlin M.E.... Bower J.D.	1990	GNRH1

Genes related to ureteral obstruction according to GeneCards:

(show all 46)

id	Symbol	Description	Score	GeneCards Section Context
1	PDGFA	platelet-derived growth factor alpha polypeptide	11.0	Publications
2	AMBP	alpha-1-microglobulin/bikunin precursor	11.0
3	BMP7	bone morphogenetic protein 7	11.0	Publications
4	CLU	clusterin	11.0
5	PTGS1	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	11.0	Publications
6	AGTR1	angiotensin II receptor, type 1	11.0	Publications
7	TGFB1	transforming growth factor, beta 1	11.0	Publications
8	DCXR	dicarbonyl/L-xylulose reductase	11.0	Publications
9	RPS26	ribosomal protein S26	11.0	Publications
10	MAP3K12	mitogen-activated protein kinase kinase kinase 12	11.0	Publications
11	SAMD7	sterile alpha motif domain containing 7	11.0	Disorders
12	MPV17L	MPV17 mitochondrial membrane protein-like	11.0
13	SFRP4	secreted frizzled-related protein 4	11.0	Publications
14	ADAMTS1	ADAM metallopeptidase with thrombospondin type 1 motif, 1	11.0	Publications
15	CLK1	CDC-like kinase 1	11.0
16	ABP1	amiloride binding protein 1 (amine oxidase (copper-containing))	11.0	Publications
17	FABP1	fatty acid binding protein 1, liver	11.0	Publications
18	HPGD	hydroxyprostaglandin dehydrogenase 15-(NAD)	11.0	Publications
19	AQP3	aquaporin 3 (Gill blood group)	11.0
20	AGTR2	angiotensin II receptor, type 2	11.0	Publications
21	AQP2	aquaporin 2 (collecting duct)	11.0	Publications
22	SLC12A1	solute carrier family 12 (sodium/potassium/chloride transporters), member 1	11.0	Publications
23	SELL	selectin L	11.0	Publications
24	SMAD7	SMAD family member 7	11.0
25	S100A4	S100 calcium binding protein A4	11.0
26	SMURF2	SMAD specific E3 ubiquitin protein ligase 2	11.0
27	NR3C2	nuclear receptor subfamily 3, group C, member 2	11.0	Publications
28	TIMP1	TIMP metallopeptidase inhibitor 1	11.0	Publications
29	SMAD3	SMAD family member 3	11.0
30	SMAD2	SMAD family member 2	11.0
31	PTPRC	protein tyrosine phosphatase, receptor type, C	11.0	Publications
32	GNRH1	gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)	11.0	Publications
33	HNF4A	hepatocyte nuclear factor 4, alpha	11.0	Publications
34	MPO	myeloperoxidase	11.0	Publications
35	NOS2	nitric oxide synthase 2, inducible	11.0	Publications
36	CYP19A1	cytochrome P450, family 19, subfamily A, polypeptide 1	11.0	Publications
37	CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	11.0	Publications
38	CDH1	cadherin 1, type 1, E-cadherin (epithelial)	11.0	Publications
39	CD36	CD36 molecule (thrombospondin receptor)	11.0	Publications
40	BMP6	bone morphogenetic protein 6	11.0	Publications
41	EPO	erythropoietin	11.0	Publications
42	MAPK8	mitogen-activated protein kinase 8	11.0	Publications
43	MAPK14	mitogen-activated protein kinase 14	11.0	Publications
44	HGF	hepatocyte growth factor (hepapoietin A; scatter factor)	11.0
45	PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	11.0	Publications
46	IFNG	interferon, gamma	11.0	Publications

Pathways related to ureteral obstruction according to GeneDecks:

(show top 50)    (show all 89)

id	Pathway	Score	Top Affiliating Genes
1	PPAR Pathway36	10.3	MAPK14
2	Actin-Based Motility by Rho Family GTPases36	10.3	BMP7
3	ACE Inhibitor Pathway, Pharmacodynamics34	10.2	AGTR2, NR3C2, AGTR1, TGFB1
4	Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics34	10.2	AGTR1, AGTR2, NR3C2, TGFB1
5	Ras Pathway36	10.2	TIMP1, GNRH1, BMP7, PDGFA
6	Breast Cancer Regulation by Stathmin136	10.1	BMP7, PDGFA, HGF
7	JNK Pathway36	9.8	BMP6, BMP7, MAPK8, TGFB1
8	Paxillin Interactions36	9.4	MAPK14, TIMP1, PDGFA, GNRH1, MAPK8
9	Glioma Invasiveness36	9.3	HGF, BMP6, BMP7, GNRH1, PDGFA, TIMP1
10	14-3-3 Induced Intracellular Signaling36	9.3	TIMP1, MAPK14, MAPK8, GNRH1, TGFB1, BMP7
11	Development TGF-beta receptor signaling10	9.2	TGFB1, SMURF2, SMAD7, SMAD3, SMAD2, MAPK14
12	Development_TGF-beta receptor signaling41	9.2	TGFB1, SMURF2, SMAD7, SMAD3, SMAD2, MAPK14
13	Telomerase Components in Cell Signaling36	9.2	BMP6, BMP7, GNRH1, PDGFA, TIMP1, HGF
14	ERK5 Signaling36	9.2	HGF, BMP6, TGFB1, PDGFA, GNRH1, BMP7
15	Apoptotic Pathways in Synovial Fibroblasts36	9.1	TGFB1, TIMP1, PDGFA, GNRH1, BMP7, BMP6
16	p53 Mediated Apoptosis36	9.1	GNRH1, BMP7, HGF, TGFB1, TIMP1, PDGFA
17	Mitochondrial Apoptosis36	9.1	HGF, TGFB1, TIMP1, PDGFA, GNRH1, BMP7
18	TGF-beta signaling pathway20	9.1	BMP6, BMP7, IFNG, SMAD3, SMAD7, SMURF2
19	NF-KappaB (p50-p65) Pathway36	9.1	PDGFA, GNRH1, BMP7, BMP6, TIMP1, HGF
20	DHA Signaling36	9.1	TIMP1, BMP6, PDGFA, BMP7, GNRH1, TGFB1
21	NF-KappaB Family Pathway36	9.0	HGF, BMP7, BMP6, GNRH1, PDGFA, TIMP1
22	Cellular Apoptosis Pathway36	9.0	GNRH1, HGF, BMP7, TGFB1, PDGFA, TIMP1
23	eIF2 Pathway36	8.9	GNRH1, HGF, PDGFA, BMP6, TGFB1, TIMP1
24	eNOS Signaling36	8.9	TGFB1, AQP3, BMP6, AQP2, BMP7, PDGFA
25	Nanog in Mammalian ESC Pluripotency36	8.9	BMP6, TGFB1, TIMP1, GNRH1, BMP7, PDGFA
26	TGF-beta Signaling Pathways37	8.8	HNF4A, MAPK8, MAPK14, SMAD2, TGFB1, SMAD3
27	Nuclear Receptor Activation by Vitamin-A36	8.8	HGF, BMP7, PDGFA, BMP6, GNRH1, TGFB1
28	Rac1 Pathway36	8.7	HGF, GNRH1, TIMP1, PDGFA, MAPK8, TGFB1
29	Chagas disease (American trypanosomiasis)20	8.6	MAPK8, SMAD2, IFNG, TGFB1, NOS2, SMAD3
30	Pathways in cancer20	8.5	PDGFA, SMAD2, NOS2, HGF, MAPK8, CDH1
31	PAK Pathway36	8.5	PDGFA, TIMP1, TGFB1, GNRH1, MAPK8, HGF
32	ILK Signaling36	8.5	HNF4A, GNRH1, TIMP1, PDGFA, BMP7, PTGS2
33	Epithelial Adherens Junctions36	8.4	TIMP1, PDGFA, BMP6, PTPRC, HNF4A, GNRH1
34	mTOR Pathway36	8.2	BMP6, BMP7, MAPK8, MAPK14, GNRH1, PDGFA
35	Leishmaniasis20	8.2	IFNG, PTGS2, NOS2, TGFB1, MAPK14
36	p70S6K Signaling36	8.2	TIMP1, TGFB1, BMP6, BMP7, MAPK8, MAPK14
37	Immune response_MIF in innate immunity response41	8.2	PTGS2, MAPK8, MAPK14, NOS2, IFNG
38	Immune response MIF in innate immunity response10	8.2	NOS2, PTGS2, IFNG, MAPK14, MAPK8
39	NFAT in Immune Response36	8.2	PDGFA, HGF, BMP6, TGFB1, TIMP1, GNRH1
40	Estrogen Pathway36	8.2	TIMP1, GNRH1, MAPK14, MAPK8, BMP7, BMP6
41	GPCR Pathway36	8.2	PDGFA, GNRH1, MAPK14, MAPK8, BMP7, BMP6
42	MAPK Family Pathway36	8.1	GNRH1, HGF, PDGFA, TIMP1, TGFB1, MAP3K12
43	Pancreatic Adenocarcinoma36	8.1	BMP6, BMP7, CDKN1A, GNRH1, PTGS2, PDGFA
44	JAK-STAT Pathway36	8.1	BMP6, BMP7, IFNG, GNRH1, PDGFA, AGTR1
45	Molecular Mechanisms of Cancer36	8.0	CDKN1A, CDH1, MAPK8, GNRH1, PDGFA, TIMP1
46	TGF-Beta Pathway36	7.9	MAPK8, MAPK14, PDGFA, GNRH1, HGF, CDH1
47	MAPK Signaling36	7.9	BMP7, MAPK8, BMP6, MAPK14, HNF4A, TIMP1
48	GSK3 Signaling36	7.9	PDGFA, GNRH1, BMP6, BMP7, CDH1, MAPK8
49	Rho Family GTPases36	7.7	GNRH1, MAPK8, BMP7, BMP6, CDH1, PDGFA
50	Renin-Angiotensin Pathway36	7.2	MAPK8, AGTR2, AGTR1, PDGFA, PTGS2, GNRH1

Compounds related to ureteral obstruction according to GeneDecks:

(show top 50)    (show all 246)

id	Compound	Score	Top Affiliating Genes
1	bleomycin32 9 9	11.9	SMAD7, SMAD2, SMAD3
2	dmso32	9.5	AQP2, CD36, PTGS1, BMP6, GNRH1
3	pirfenidone32	9.3	TGFB1, IFNG, CD36, BMP7, BMP6
4	egcg32	9.3	TIMP1, MAPK8, MAPK14, PTGS1
5	threonine32	9.2	SLC12A1, HNF4A, HPGD, MAP3K12, AQP3, AQP2
6	ns 39832 42	10.2	MAPK8, TGFB1, PTGS1, MAPK14, NOS2
7	dihydrotestosterone32 9 18 9	12.1	SMAD2, BMP6, CLU, GNRH1, HPGD, CYP19A1
8	pge232	9.1	BMP7, CDH1, AQP2, HPGD, PTGS1, CYP19A1
9	cyclosporin a32 42	10.0	AQP2, HGF, TGFB1, TIMP1, GNRH1, NR3C2
10	enalapril32 9 9	11.0	BMP6, AGTR2, AGTR1, AMBP, BMP7, EPO
11	ang ii32	8.9	AGTR1, TGFB1, CD36, MAPK8, NR3C2, AGTR2
12	aminoguanidine32 9 9	10.9	AGTR1, ABP1, NOS2, IFNG, EPO, CLU
13	progesterone32 42 9 18 9	12.9	BMP7, CLU, PTPRC, SFRP4, GNRH1, CDKN1A
14	h2o232	8.8	AGTR1, PTPRC, MAPK14, MAPK8, FABP1, CLU
15	losartan32 34 9 9	11.7	AGTR1, HGF, BMP6, CD36, NR3C2, SMAD2
16	n acetylcysteine32	8.6	HGF, TIMP1, CLU, CDKN1A, CDH1, PTPRC
17	calcitriol32 42 9 18 9	12.5	CLU, BMP7, BMP6, SFRP4, CD36, EPO
18	heparin32 9 18 9	11.5	ABP1, CDH1, CD36, MPO, AGTR1, TIMP1
19	paraffin32	7.9	PDGFA, SELL, CLU, CDKN1A, CD36, CDH1
20	estrogen32	7.7	TIMP1, AGTR2, BMP7, GNRH1, HPGD, HNF4A
21	ly29400232	7.7	NOS2, SMAD3, SMAD2, PTGS1, PTGS2, MAPK14
22	tgf beta132	7.7	AGTR1, CDKN1A, HGF, CD36, CDH1, SMAD2
23	lactate32	7.7	HGF, EPO, TIMP1, MPO, SELL, BMP6
24	aspirin32 34 18	9.6	HGF, PTGS1, PTGS2, HNF4A, CDH1, BMP6
25	matrigel32	7.6	BMP6, S100A4, HGF, TIMP1, SMAD2, HNF4A
26	superoxide32 18	8.4	CLU, MPO, FABP1, SELL, MAPK8, MAPK14
27	curcumin32	7.4	PTGS1, PTGS2, TGFB1, MAPK14, MAPK8, CDH1
28	celecoxib32 42 34 9 18 9	12.4	PTGS1, CDKN1A, CDH1, MAPK8, MAPK14, EPO
29	alanine32	7.3	SELL, TIMP1, BMP6, HGF, GNRH1, AGTR2
30	15-deoxy-delta-12,14-prostaglandin j232	7.1	BMP6, IFNG, MAPK14, MAPK8, CD36, CDKN1A
31	sb 20358032 42	8.0	SMAD3, SMAD7, AGTR1, TIMP1, HGF, SMAD2
32	pdtc32	7.0	MAPK8, IFNG, MAPK14, HGF, TGFB1, NOS2
33	creatinine32	7.0	SELL, BMP6, BMP7, MPO, CD36, CDH1
34	retinoid32	6.9	BMP6, CDH1, MAPK8, MAPK14, IFNG, HNF4A
35	oxygen32 18	7.8	PDGFA, NOS2, ABP1, AGTR1, HGF, AGTR2
36	vitamin d32	6.8	BMP7, CLU, CDKN1A, CD36, CDH1, HPGD
37	butyrate32	6.5	BMP6, CLU, MPO, CDKN1A, CDH1, MAPK8
38	nitric oxide32 9 18 9	9.3	MAPK14, HNF4A, AQP2, MPO, BMP6, IFNG
39	actinomycin d32	6.3	CLU, CDKN1A, MAPK8, MAPK14, IFNG, GNRH1
40	pd 98,05932	6.3	PTGS2, SMAD7, TIMP1, SMAD2, TGFB1, HNF4A
41	herbimycin a32 42	7.0	SELL, BMP6, CD36, CDH1, MAPK8, MAPK14
42	indomethacin32 9 9	7.9	HPGD, HNF4A, PTGS2, PTGS1, CYP19A1, NOS2
43	cisplatin32 34 9 9	8.7	EPO, MAPK8, MAPK14, AMBP, GNRH1, PTGS2
44	genistein32 9 18 9	8.7	MAPK8, IFNG, PTGS1, PTPRC, CYP19A1, HGF
45	tyrosine32	5.4	MAPK14, CDH1, EPO, S100A4, CLU, BMP6
46	serine32	5.1	HGF, HNF4A, PTGS1, PTPRC, NR3C2, SMAD2
47	retinoic acid32 42 18	6.9	CLU, S100A4, MPO, CDKN1A, CD36, CDH1
48	cycloheximide32	4.6	AGTR2, CD36, CDKN1A, CLU, BMP7, BMP6
49	vegf32	4.1	PTGS2, EPO, HGF, PTGS1, SMAD2, SMAD3
50	dexamethasone32 42 34 9 9	7.7	GNRH1, HPGD, HNF4A, PTGS2, PTGS1, PTPRC

Cellular components related to ureteral obstruction according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	platelet alpha granule lumen	GO:031093	9.1	HGF, TGFB1, TIMP1, PDGFA, CLU
2	nucleoplasm	GO:005654	7.9	SMAD7, SMAD3, SMAD2, NR3C2, HNF4A, MAPK14
3	extracellular space	GO:005615	7.4	SFRP4, EPO, HGF, TGFB1, ABP1, PDGFA

Biological processes related to ureteral obstruction according to GeneDecks:

(show all 42)

id	Name	GO ID	Score	Top Affiliating Genes
1	pathway-restricted SMAD protein phosphorylation	GO:060389	10.5	TGFB1, SMAD7, BMP7
2	evasion or tolerance of host defenses by virus	GO:019049	10.4	TGFB1, SMAD3
3	regulation of DNA biosynthetic process	GO:2000278	10.4	PDGFA, CDKN1A
4	regulation of binding	GO:051098	10.4	SMAD2, SMAD3, TGFB1
5	SMAD protein complex assembly	GO:007183	10.3	TGFB1, SMAD3, SMAD2
6	endoderm development	GO:007492	10.3	TGFB1, SMAD3, SMAD2
7	negative regulation of mitotic cell cycle	GO:045930	10.3	TGFB1, SMAD3, HNF4A
8	positive regulation of epithelial to mesenchymal transition	GO:010718	10.2	TGFB1, SMAD3, SMAD2
9	female pregnancy	GO:007565	10.2	TGFB1, HPGD, GNRH1, AMBP, AQP2
10	ureteric bud development	GO:001657	10.1	TGFB1, SMAD7, SMAD3, SMAD2, BMP7
11	positive regulation of bone mineralization	GO:030501	10.1	BMP6, BMP7, SMAD3, TGFB1
12	SMAD protein signal transduction	GO:060395	10.1	HNF4A, BMP7, BMP6
13	regulation of transforming growth factor beta receptor signaling pathway	GO:017015	10.1	SMAD2, SMAD3, SMAD7, SMURF2, TGFB1
14	negative regulation of transforming growth factor beta receptor signaling pathway	GO:030512	10.0	TGFB1, SMURF2, SMAD7, SMAD3, SMAD2
15	BMP signaling pathway	GO:030509	10.0	BMP6, BMP7, SMAD7, SMURF2
16	positive regulation of pathway-restricted SMAD protein phosphorylation	GO:010862	10.0	BMP6, BMP7, TGFB1
17	cell-cell junction organization	GO:045216	9.9	TGFB1, SMAD3, HNF4A, CDH1
18	aging	GO:007568	9.9	EPO, TGFB1, TIMP1, PTGS1, AQP2
19	transforming growth factor beta receptor signaling pathway	GO:007179	9.9	TGFB1, SMURF2, SMAD7, SMAD3, SMAD2, HPGD
20	epithelial to mesenchymal transition	GO:001837	9.9	HGF, TGFB1, S100A4, BMP7
21	negative regulation of cell growth	GO:030308	9.8	TGFB1, AGTR2, SMAD3, HNF4A, CDKN1A
22	cyclooxygenase pathway	GO:019371	9.8	PTGS1, PTGS2
23	paraxial mesoderm morphogenesis	GO:048340	9.8	SMAD3, SMAD2
24	response to vitamin D	GO:033280	9.7	TGFB1, PTGS2, AQP3
25	stress-induced premature senescence	GO:090400	9.7	MAPK14, CDKN1A
26	transcription initiation from RNA polymerase II promoter	GO:006367	9.7	HNF4A, NR3C2, SMAD2, SMAD3, SMAD7, SMURF2
27	response to glucose stimulus	GO:009749	9.6	TGFB1, SMAD2, HNF4A, MAPK14
28	positive regulation of reactive oxygen species metabolic process	GO:2000379	9.6	AGTR1, MAPK14, CD36, CDKN1A
29	positive regulation of killing of cells of other organism	GO:051712	9.6	NOS2, IFNG
30	platelet degranulation	GO:002576	9.5	HGF, TGFB1, TIMP1, PDGFA, CD36, CLU
31	peptidyl-serine phosphorylation	GO:018105	9.3	EPO, MAP3K12, MAPK14, MAPK8, CLK1
32	response to estradiol stimulus	GO:032355	9.3	TGFB1, CYP19A1, PTGS2, SFRP4
33	cellular response to hypoxia	GO:071456	9.2	EPO, PTGS2, FABP1, BMP7
34	positive regulation of transcription, DNA-dependent	GO:045893	9.1	EPO, TGFB1, AGTR2, SMAD3, SMAD2, HNF4A
35	negative regulation of apoptotic process	GO:043066	9.1	EPO, TIMP1, SMAD3, MAPK8, FABP1, CDKN1A
36	platelet activation	GO:030168	8.9	HGF, TGFB1, TIMP1, PDGFA, MAPK14, CD36
37	cell surface receptor signaling pathway	GO:007166	8.9	AGTR2, PTPRC, IFNG, MAPK14, CD36
38	negative regulation of transcription from RNA polymerase II promoter	GO:000122	8.8	SMURF2, SMAD7, SMAD3, SMAD2, IFNG, CD36
39	negative regulation of cell proliferation	GO:008285	8.7	ADAMTS1, TGFB1, SMAD2, PTGS2, HNF4A, GNRH1
40	positive regulation of transcription from RNA polymerase II promoter	GO:045944	8.3	TGFB1, SMAD7, SMAD3, SMAD2, HNF4A, IFNG
41	blood coagulation	GO:007596	8.3	HGF, TGFB1, TIMP1, PDGFA, NOS2, HNF4A
42	response to drug	GO:042493	8.2	TGFB1, ABP1, CYP19A1, PTGS2, HNF4A, IFNG

Molecular functions related to ureteral obstruction according to GeneDecks:

(show all 8)

id	Name	GO ID	Score	Top Affiliating Genes
1	eukaryotic cell surface binding	GO:043499	9.9	PDGFA, TGFB1, EPO
2	heparin binding	GO:008201	9.7	ADAMTS1, ABP1, PTPRC, MPO, SELL
3	prostaglandin-endoperoxide synthase activity	GO:004666	9.6	PTGS2, PTGS1
4	peroxidase activity	GO:004601	9.2	MPO, PTGS2, PTGS1
5	growth factor activity	GO:008083	8.9	HGF, TGFB1, PDGFA, BMP7, BMP6
6	heme binding	GO:020037	8.8	NOS2, CYP19A1, PTGS1, PTGS2, AMBP, MPO
7	protein homodimerization activity	GO:042803	8.5	MAP3K12, TGFB1, ABP1, PDGFA, NOS2, SMAD3
8	protein binding	GO:005515	5.0	SMAD3, SMAD7, SMURF2, NOS2, RPS26, AGTR1