MCID: URT010
MIFTS: 48

Ureteral Obstruction malady

Summaries for Ureteral Obstruction

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33MalaCards
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MalaCards: Ureteral Obstruction is related to hydronephrosis and vesicoureteral reflux. An important gene associated with Ureteral Obstruction is PTGS1 (prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)), and among its related pathways are p70S6K Signaling and Passive Transport by Aquaporins. The compounds angiotensin iii and angiotensin i have been mentioned in the context of this disorder. Affiliated tissues include liver, kidney and lymph node, and related mouse phenotypes are integument and reproductive system.

Aliases & Classifications for Ureteral Obstruction

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 27ICD9CM, 61UMLS, 57SNOMED-CT
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Aliases & Descriptions:

ureteral obstruction 8 10 45


External Ids:

Disease Ontology8 DOID:5199
SNOMED-CT57 197807001
ICD9CM27 593.4

Related Diseases for Ureteral Obstruction

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Ureteral Obstruction via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 107)
idRelated DiseaseScoreTop Affiliating Genes
1hydronephrosis30.8AGTR2
2vesicoureteral reflux30.6AGTR1, AGTR2, AMBP
3ureteral disease30.5BMP7, AQP3, AQP2, TGFB1
4diabetes insipidus30.2AQP2
5nephrogenic diabetes insipidus30.2AQP2, AQP3
6adenoma30.2PTGS1, HPGD, AGTR2, FABP1
7adenocarcinoma30.0AMBP, PDGFA, AGTR1, CLU, PTGS1, AQP3
8retroperitoneal fibrosis10.5
9anuria10.5
10pelvic lipomatosis10.4
11aortic aneurysm10.3
12ureter cancer10.3
13abdominal aortic aneurysm10.3
14renal dysplasia10.3
15aortitis10.2
16amyloidosis10.2
17desmoid tumor10.2
18ovarian remnant syndrome10.2
19hypoxia10.2
20nephritis10.2
21congenital hydronephrosis10.2
22nephrogenic adenoma10.0
23corpus luteum cyst10.0
24discitis10.0
25acute pancreatitis10.0
26myoma10.0
27cystitis cystica10.0
28xanthogranulomatous pyelonephritis10.0
29renal agenesis10.0
30erdheim-chester disease10.0
31chronic granulomatous disease10.0
32henoch-schoenlein purpura10.0
33familial adenomatous polyposis10.0
34immune-complex glomerulonephritis10.0
35nephrolithiasis10.0
36glandular cystitis10.0
37actinomycosis10.0
38myeloid sarcoma10.0
39ureteral lymphoma10.0
40ureterolithiasis10.0
41ureter adenocarcinoma10.0
42lymphoplasmacytic lymphoma10.0
43retroperitoneal lymphoma10.0
44ureter inverted papilloma10.0
45cystic lymphangioma10.0
46acute leukemia10.0
47hepatic coma10.0
48acute kidney failure10.0
49bladder diverticulum10.0
50transitional cell carcinoma10.0

Graphical network of the top 20 diseases related to Ureteral Obstruction:



Diseases related to ureteral obstruction

Clinical Features for Ureteral Obstruction

Drugs & Therapeutics for Ureteral Obstruction

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Ureteral Obstruction

Drug clinical trials:

Search ClinicalTrials for Ureteral Obstruction

Search NIH Clinical Center for Ureteral Obstruction

Search CenterWatch for Ureteral Obstruction

Genetic Tests for Ureteral Obstruction

Anatomical Context for Ureteral Obstruction

Sources:
33MalaCards
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MalaCards organs/tissues related to Ureteral Obstruction:

33
Liver, Kidney, Lymph node, Bone marrow, Cortex, Smooth muscle, Colon, Breast, Prostate, Myeloid, Monocytes, B lymphoblasts, B cells, Endothelial, Fetal liver

Animal Models for Ureteral Obstruction or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Ureteral Obstruction

Sources:
51PubMed
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Articles related to Ureteral Obstruction:

(show top 50)    (show all 539)
idTitleAuthorsYear
1
Proximal tubule PPARI+ attenuates renal fibrosis and inflammation caused by unilateral ureteral obstruction. (23804447)
2013
2
Quality-of-life assessment after palliative interventions to manage malignant ureteral obstruction. (23404519)
2013
3
Renal functional decline and glomerulotubular injury are arrested but not restored by release of unilateral ureteral obstruction (UUO). (23220725)
2013
4
Therapeutic effects of human amniotic fluid-derived stem cells on renal interstitial fibrosis in a murine model of unilateral ureteral obstruction. (23724119)
2013
5
Long-term results of metallic stents for malignant ureteral obstruction in advanced cervical carcinoma. (23199302)
2013
6
Would the Indwelling Internal Ureteral Stent Influence Renal Function Despite Relief of Benign Ureteral Obstruction? (24032464)
2013
7
The effect of simvastatin and erythropoietin on renal fibrosis in rats with unilateral ureteral obstruction. (24083846)
2013
8
Acute bilateral ureteral obstruction secondary to guaifenesin toxicity. (24128843)
2013
9
Transforming growth factor-I^1 receptor inhibition preserves glomerulotubular integrity during ureteral obstruction in adults but worsens injury in neonatal mice. (23303407)
2013
10
A peculiar complication of suprapubic catheterization: recurrent ureteral obstruction and hydronephrosis. (23809534)
2013
11
TGF-I^1 a89 SMAD/p53/USF2 a89 PAI-1 transcriptional axis in ureteral obstruction-induced renal fibrosis. (21638209)
2012
12
Orchiectomy attenuates kidney fibrosis after ureteral obstruction by reduction of oxidative stress in mice. (22143161)
2012
13
Association of PAX2 with cell apoptosis in unilateral ureteral obstruction rats. (22229793)
2012
14
Noncontrast multidetector-row computed tomography scanning for detection of radiolucent calculi in acute renal insufficiency caused by bilateral ureteral obstruction of ceftriaxone crystals. (22398584)
2012
15
Basigin/CD147 promotes renal fibrosis after unilateral ureteral obstruction. (21281789)
2011
16
Alterations in urinary metabolites due to unilateral ureteral obstruction in a rodent model. (21547298)
2011
17
Stent failure in the management of malignant extrinsic ureteral obstruction: risk factors. (21518020)
2011
18
Postpartum ovarian vein thrombosis presenting as ureteral obstruction. (22767678)
2010
19
Ureteral obstruction: is the full metallic double-pigtail stent the way to go? (19232816)
2010
20
Postobstructive regeneration of kidney is derailed when surge in renal stem cells during course of unilateral ureteral obstruction is halted. (19906947)
2010
21
INK4a knockout mice exhibit increased fibrosis under normal conditions and in response to unilateral ureteral obstruction. (20861074)
2010
22
A reduction of unilateral ureteral obstruction-induced renal fibrosis by a therapy combining valsartan with aliskiren. (20685818)
2010
23
Melatonin attenuates unilateral ureteral obstruction-induced renal injury by reducing oxidative stress, iNOS, MAPK, and NF-kB expression. (19530942)
2009
24
Evaluation of urothelial stretch-induced cyclooxygenase-2 expression in a mouse ureteral obstruction model. (19193137)
2009
25
Long-term EGF treatment partially prevents reduction of renal blood flow in response to neonatally induced partial unilateral ureteral obstruction. (19142026)
2009
26
Discrepancy between serum levels of low molecular weight proteins in acute kidney injury model rats with bilateral ureteral obstruction and bilateral nephrectomy. (19536607)
2009
27
Acute renal failure due to ureteral obstruction in a kidney transplant recipient with Candida albicans contamination of preservation fluid. (19392732)
2009
28
Persistent bilateral ureteral obstruction secondary to endometriosis despite treatment with an aromatase inhibitor. (18555228)
2008
29
Partial unilateral ureteral obstruction in newborn mice: magnetic resonance imaging and pathology studies. (18295263)
2008
30
Alterations in renal cilium length during transient complete ureteral obstruction in the mouse. (18537851)
2008
31
Erythropoietin decreases renal fibrosis in mice with ureteral obstruction: role of inhibiting TGF-beta-induced epithelial-to-mesenchymal transition. (17389738)
2007
32
Influence of irbesartan on expression of ILK and its relationship with epithelial-mesenchymal transition in mice with unilateral ureteral obstruction. (17959033)
2007
33
Altered regulation of renin-angiotensin, endothelin and natriuretic peptide systems in rat kidney with chronic unilateral ureteral obstruction. (17851289)
2007
34
Retrograde ureteral stents for extrinsic ureteral obstruction: nine years' experience at University of Michigan. (18068437)
2007
35
Re: Unusual cause of ureteral obstruction in transplant kidney. (17468809)
2007
36
Scintigraphic demonstration of urine extravasation secondary to acute ureteral obstruction: a case report and some considerations about acute ureteral obstruction. (17619724)
2006
37
Changes of microvascular perfusion during acute ureteral obstruction in the rat kidney - the influence of gastrin releasing peptide. (16687791)
2006
38
A case report of emphysematous pyelonephritis secondary to ureteral obstruction in a non-diabetic patient. (16984853)
2006
39
Activation of ERK in renal fibrosis after unilateral ureteral obstruction: modulation by antioxidants. (15698432)
2005
40
Non-invasive evaluation of bilateral renal regional blood flow and tubular dynamics during acute unilateral ureteral obstruction. (15632349)
2005
41
Low risk of ureteral obstruction with "deep" (dorsal/posterior) uterosacral ligament suture placement for transvaginal apical suspension. (15902153)
2005
42
Elevated plasma concentrations of transforming growth factor-beta 1 in patients with unilateral ureteral obstruction. (16315065)
2005
43
Using two ipsilateral double j ureteral stents for extrinsic ureteral obstruction due to colon carcinoma. (16327298)
2005
44
Renal structural and functional repair in a mouse model of reversal of ureteral obstruction. (16221872)
2005
45
Pathophysiology of unilateral ureteral obstruction: studies from Charlottesville to New York. (15538209)
2004
46
Renal hemodynamic and ureteral pressure changes in response to ureteral obstruction: the role of nitric oxide. (12478193)
2003
47
Fasudil attenuates interstitial fibrosis in rat kidneys with unilateral ureteral obstruction. (12445583)
2002
48
Diminished renal expression of aquaporin water channels in rats with experimental bilateral ureteral obstruction. (11562400)
2001
49
Covered metallic ureteral stent in the management of malignant ureteral obstruction: preliminary results. (11744459)
2001
50
Gastrocystoplasty in a woman with radiation-induced ureteral obstruction and low-compliance bladder. (9792987)
1998

Genetic Variations for Ureteral Obstruction

Expression for genes affiliated with Ureteral Obstruction

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Ureteral Obstruction

Search GEO for disease gene expression data for Ureteral Obstruction.

Pathways for genes affiliated with Ureteral Obstruction

Sources:
52QIAGEN, 54Reactome, 50PharmGKB, 38NCBI BioSystems Database
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Compounds for genes affiliated with Ureteral Obstruction

Sources:
29IUPHAR, 45Novoseek, 11DrugBank, 50PharmGKB, 60Tocris Bioscience, 24HMDB
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Compounds related to Ureteral Obstruction according to GeneCards/GeneDecks:

(show all 50)
idCompoundScoreTop Affiliating Genes
1angiotensin iii2910.7AGTR2, AGTR1
2angiotensin i2910.7AGTR2, AGTR1
3etoperidone4510.7AGTR2, AGTR1
413,14-dihydro-15-keto-pge24510.7HPGD, PTGS1
5Tasosartan1110.7AGTR1, AGTR2
6cgp42112a4510.6AGTR1, AGTR2
7pge24510.6AQP2, TGFB1
8irbesartan45 29 50 1113.6PTGS1, AGTR1, AGTR2
9cyclosporin a45 29 6012.6AQP2, AMBP
10saralasin4510.6AGTR1, AGTR2
11candesartan45 29 1112.6AGTR2, AGTR1, PTGS1, TGFB1
12angiotensin ii29 2411.6AGTR1, AGTR2
13ang ii4510.6AGTR2, AGTR1, TGFB1
14mercury4510.6AMBP, AQP3, AQP2
15deoxyribonucleic acid4510.5BMP7, AGTR1, CLU
16benazepril45 1111.5TGFB1, AGTR1
17enalapril45 50 1112.5AGTR1, AGTR2, BMP7, AMBP
18losartan45 50 29 1113.5TGFB1, AGTR1, AGTR2, PDGFA
19pd12331945 2911.5AGTR2, AGTR1
20hgcl24510.5AQP2, AQP3
21agarose4510.5AMBP, BMP7, CLU, TGFB1
22hg2+2910.4AQP3, AQP2
23tgf beta14510.4PDGFA, BMP7, AGTR1, ADAMTS1, TGFB1
24ribonucleic acid4510.4PDGFA, BMP7, HPGD, CLU, TGFB1
25ethanol45 50 11 2413.4FABP1, BMP7, AGTR2, AGTR1, CLU
26calcitriol45 60 11 2413.4SFRP4, BMP7, HPGD, CLU, TGFB1
27arachidonic acid45 29 11 2413.4PTGS1, HPGD, AGTR1, AGTR2, FABP1
28inulin4510.3AMBP, CLU
29prostaglandin4510.3AMBP, AGTR2, AGTR1, HPGD, PTGS1, AQP2
30cisplatin45 50 60 1113.3AMBP, AGTR1, CLU, AQP2, TGFB1
31vitamin d4510.3PDGFA, BMP7, AGTR1, HPGD, CLU, PTGS1
32cycloheximide4510.3PDGFA, BMP7, AGTR2, AGTR1, CLU, PTGS1
33vegf4510.2PDGFA, FABP1, BMP7, AGTR1, CLU, PTGS1
34sodium45 2411.2AMBP, SFRP4, AGTR2, AGTR1, AQP2
35heparin45 29 11 2413.2PDGFA, BMP7, AGTR1, CLU, ADAMTS1
36sodium nitroprusside4510.2TGFB1, PTGS1, AGTR1
37indomethacin45 60 29 1113.2TGFB1, PTGS1, HPGD, AGTR2
38alanine4510.2AMBP, AGTR2, AGTR1, HPGD, PTGS1, AQP2
39threonine4510.2BMP7, MAP3K12, HPGD, AQP3, AQP2, TGFB1
40silver4510.2AQP3, AGTR1, AMBP
41progesterone45 60 29 11 2414.2SFRP4, PDGFA, BMP7, HPGD, CLU, ADAMTS1
42glucose4510.2AMBP, FABP1, BMP7, DCXR, AGTR1, AQP3
43creatinine4510.1AMBP, FABP1, BMP7, AGTR2, AGTR1, AQP3
44dexamethasone45 50 29 1113.1TGFB1, PDGFA, FABP1, BMP7, HPGD, CLU
45oxygen45 2411.1PDGFA, BMP7, AGTR2, AGTR1, CLU, PTGS1
46retinoic acid45 2411.1AMBP, PDGFA, FABP1, BMP7, MAP3K12, CLU
47methionine4510.0AMBP, FABP1, HPGD, AQP2
48calcium45 50 11 2412.9AMBP, SFRP4, PDGFA, BMP7, AGTR2, AGTR1
49serine459.8AMBP, BMP7, AGTR1, MAP3K12, HPGD, CLU
50cysteine459.6AMBP, AGTR1, HPGD, CLU, PTGS1, AQP2

GO Terms for genes affiliated with Ureteral Obstruction

Sources:
16Gene Ontology
See all sources

Cellular components related to Ureteral Obstruction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1microvillusGO:00590210.1TGFB1, DCXR, PDGFA
2platelet alpha granule lumenGO:0310939.9TGFB1, CLU, PDGFA
3extracellular spaceGO:0056159.8SFRP4, PDGFA, BMP7, CLU, TGFB1, AMBP

Biological processes related to Ureteral Obstruction according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1renin-angiotensin regulation of aldosterone productionGO:00201810.5AGTR1, AGTR2
2cellular response to dexamethasone stimulusGO:07154910.5AGTR2, TGFB1
3negative regulation of immune responseGO:05077710.5TGFB1, AMBP
4negative regulation of cell cycleGO:04578610.4BMP7, HPGD, TGFB1
5positive regulation of cellular protein metabolic processGO:03227010.4TGFB1, AGTR1
6platelet degranulationGO:00257610.4TGFB1, CLU, PDGFA
7response to vitamin DGO:03328010.3TGFB1, AQP3
8female pregnancyGO:00756510.3TGFB1, AQP2, HPGD, AMBP
9negative regulation of blood vessel endothelial cell migrationGO:04353710.3AGTR2, TGFB1
10positive regulation of apoptotic processGO:04306510.2SFRP4, BMP7, CLU, TGFB1
11cyclooxygenase pathwayGO:01937110.2HPGD, PTGS1
12embryo developmentGO:00979010.1TGFB1, PDGFA, SFRP4
13positive regulation of peptidyl-threonine phosphorylationGO:01080010.0BMP7, TGFB1

Molecular functions related to Ureteral Obstruction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1angiotensin type II receptor activityGO:00494510.0AGTR1, AGTR2
2protein homodimerization activityGO:0428039.9TGFB1, HPGD, MAP3K12, PDGFA, AMBP

Products for genes affiliated with Ureteral Obstruction

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Sources for Ureteral Obstruction

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet