MCID: URT010
MIFTS: 49

Ureteral Obstruction malady

Summaries for Ureteral Obstruction

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32MalaCards
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MalaCards: Ureteral Obstruction is related to hydronephrosis and vesicoureteral reflux. An important gene associated with Ureteral Obstruction is PTGS1 (prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)), and among its related pathways are p70S6K Signaling and Passive Transport by Aquaporins. The compounds angiotensin iii and angiotensin i have been mentioned in the context of this disorder. Affiliated tissues include kidney, bone and bone marrow, and related mouse phenotypes are integument and reproductive system.

Aliases & Classifications for Ureteral Obstruction

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8Disease Ontology, 10DISEASES, 44Novoseek, 27ICD9CM, 60UMLS, 56SNOMED-CT
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Aliases & Descriptions:

ureteral obstruction 8 10 44


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Disease Ontology8 DOID:5199
SNOMED-CT56 197807001
ICD9CM27 593.4

Related Diseases for Ureteral Obstruction

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17GeneCards, 18GeneDecks
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Diseases related to Ureteral Obstruction via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 118)
idRelated DiseaseScoreTop Affiliating Genes
1hydronephrosis30.8AGTR2
2vesicoureteral reflux30.6AGTR1, AGTR2, AMBP
3ureteral disease30.5BMP7, AQP3, AQP2, TGFB1
4hypertension30.3TGFB1, AGTR1
5ischemia30.3CLU, AGTR2, BMP7
6pancreatitis30.2TGFB1
7diabetes insipidus30.2AQP2
8nephrogenic diabetes insipidus30.2AQP2, AQP3
9glomerulonephritis30.0AMBP, AGTR1, CLU, TGFB1
10adenoma30.0PTGS1, HPGD, AGTR2, FABP1
11prostate cancer30.0TGFB1, PTGS1, CLU, BMP7
12adenocarcinoma30.0AMBP, PDGFA, AGTR1, CLU, PTGS1, AQP3
13anuria10.5
14endometriosis10.4
15pelvic lipomatosis10.4
16lipomatosis10.4
17aortic aneurysm10.3
18renal artery obstruction10.2
19abdominal aortic aneurysm10.2
20perinephritis10.2
21aortitis10.2
22amyloidosis10.2
23cervicitis10.2
24osteomyelitis10.2
25prostatitis10.2
26pyelonephritis10.2
27schistosomiasis10.2
28vaginitis10.2
29nephrogenic adenoma10.0
30corpus luteum cyst10.0
31discitis10.0
32acute pancreatitis10.0
33myoma10.0
34cystitis cystica10.0
35xanthogranulomatous pyelonephritis10.0
36renal agenesis10.0
37erdheim-chester disease10.0
38chronic granulomatous disease10.0
39henoch-schoenlein purpura10.0
40familial adenomatous polyposis10.0
41low compliance bladder10.0
42immune-complex glomerulonephritis10.0
43nephrolithiasis10.0
44actinomycosis10.0
45myeloid sarcoma10.0
46duodenitis10.0
47ureteral lymphoma10.0
48ureterolithiasis10.0
49lymphoplasmacytic lymphoma10.0
50retroperitoneal lymphoma10.0

Graphical network of the top 20 diseases related to Ureteral Obstruction:



Diseases related to ureteral obstruction

Clinical Features for Ureteral Obstruction

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Drugs & Therapeutics for Ureteral Obstruction

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Ureteral Obstruction

Drug clinical trials:

Search ClinicalTrials for Ureteral Obstruction

Search NIH Clinical Center for Ureteral Obstruction

Search CenterWatch for Ureteral Obstruction

Genetic Tests for Ureteral Obstruction

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Anatomical Context for Ureteral Obstruction

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32MalaCards
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MalaCards organs/tissues related to Ureteral Obstruction:

32
Kidney, Bone, Bone marrow, Monocytes, Endothelial, Colon, Smooth muscle, Prostate, Myeloid, Liver, Cortex, Breast, Uterus, Lymph node

Animal Models for Ureteral Obstruction or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Ureteral Obstruction:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107719.8TGFB1, AQP2, CLK1, AGTR2, BMP7, PDGFA
2MP:00053899.8AMBP, SFRP4, PDGFA, PTGS1, ADAMTS1, AQP2
3MP:00053859.6SFRP4, PDGFA, BMP7, AGTR2, AGTR1, HPGD
4MP:00053679.5TGFB1, SFRP4, PDGFA, BMP7, AGTR2, AGTR1
5MP:00053799.5AMBP, BMP7, AGTR2, HPGD, PTGS1, ADAMTS1
6MP:00053789.3SFRP4, PDGFA, BMP7, AGTR2, AGTR1, CLK1
7MP:00107689.1AGTR1, AGTR2, BMP7, PDGFA, SFRP4, MAP3K12
8MP:00053769.1MAP3K12, AGTR1, AGTR2, FABP1, PDGFA, SFRP4

Publications for Ureteral Obstruction

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50PubMed
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Articles related to Ureteral Obstruction:

(show top 50)    (show all 586)
idTitleAuthorsYear
1
Resveratrol as a therapeutic agent for renal fibrosis induced by unilateral ureteral obstruction. (24152192)
2013
2
Racial disparities in the use of palliative therapy for ureteral obstruction among elderly patients with advanced prostate cancer. (23292697)
2013
3
Re: Symptomatic bilateral delayed partial ureteral obstruction after bilateral endoscopic correction of vesicoureteral reflux with dextranomer/hyaluronic acid polymer. (23931230)
2013
4
Cystoscopic extraction technique and external drainage rescue of a failed attempt to traverse a severe transplanted ureteral obstruction. (24363871)
2013
5
Re: Wenske et al.: Outcomes of distal ureteral reconstruction through reimplantation with psoas hitch, Boari flap, or ureteroneocystostomy for benign or malignant ureteral obstruction or injury (Urology 2013;82:231-236). (24074992)
2013
6
Pelvi-ureteric junction obstruction in autosomal-dominant polycystic kidney disease: an association yet to be reported. (22778470)
2012
7
Alteration of renal cyclooxygenase expression due to partial unilateral ureteral obstruction in neonatal. (22398203)
2012
8
Unusual malignant ureteral obstruction and management. (22875445)
2012
9
Atorvastatin prevents the downregulation of aquaporin-2 receptor after bilateral ureteral obstruction and protects renal function in a rat model. (22503765)
2012
10
Robotic ureterolysis for relief of ureteral obstruction from retroperitoneal fibrosis. (21296397)
2011
11
The Nrf2-Keap1 cellular defense pathway and heat shock protein 70 (Hsp70) response. Role in protection against oxidative stress in early neonatal unilateral ureteral obstruction (UUO). (20734248)
2011
12
Presence of bioactive lysophosphatidic acid in renal effluent of rats with unilateral ureteral obstruction. (21693124)
2011
13
28S-ribosomal RNA is superior to glyceraldehyde-3-phosphate dehydrogenase as a RNA reference gene in p53-deficient mice with unilateral ureteral obstruction. (21565186)
2011
14
Ureteral obstruction: is the full metallic double-pigtail stent the way to go? (19232816)
2010
15
Melatonin attenuates unilateral ureteral obstruction-induced renal injury by reducing oxidative stress, iNOS, MAPK, and NF-kB expression. (19530942)
2009
16
Re: Management of ureteral obstruction due to advanced malignancy: optimizing therapeutic and palliative outcomes: E. Kouba, E. M. Wallen and R. S. Pruthi J Urol 2008; 180: 444-450. (19157435)
2009
17
Persistent bilateral ureteral obstruction secondary to endometriosis despite treatment with an aromatase inhibitor. (18555228)
2008
18
Robotically assisted excision of ovarian vein for intermittent ureteral obstruction. (18435891)
2008
19
Suppression of renal alpha-dicarbonyl compounds generated following ureteral obstruction by kidney-specific alpha-dicarbonyl/L-xylulose reductase. (18079483)
2008
20
Nonerythropoietic derivative of erythropoietin protects against tubulointerstitial injury in a unilateral ureteral obstruction model. (18194980)
2008
21
Altered expression of epithelial sodium channel in rats with bilateral or unilateral ureteral obstruction. (17475897)
2007
22
Comparison of the effects of captopril, tamoxifen and L-carnitine on renal structure and fibrosis after total unilateral ureteral obstruction in the rat. (17454945)
2007
23
Bilateral pelvi-ureteric junction obstruction in a neonate presenting with sudden anuria. (18947670)
2006
24
Tissue inhibitor of metalloproteinase-3 plays important roles in the kidney following unilateral ureteral obstruction. (16778336)
2006
25
Ureteral obstruction after dextranomer/hyaluronic acid copolymer injection for treatment of secondary vesicoureteral reflux after renal transplantation. (16808962)
2006
26
Compensatory renal growth due to neonatal ureteral obstruction: implications for clinical studies. (16382318)
2006
27
Evaluation of the effects of ischemic injury and ureteral obstruction on delayed graft function in cats after renal autotransplantation. (16756614)
2006
28
Activation of ERK in renal fibrosis after unilateral ureteral obstruction: modulation by antioxidants. (15698432)
2005
29
Low risk of ureteral obstruction with "deep" (dorsal/posterior) uterosacral ligament suture placement for transvaginal apical suspension. (15902153)
2005
30
Elevated plasma concentrations of transforming growth factor-beta 1 in patients with unilateral ureteral obstruction. (16315065)
2005
31
Suppression of 15-hydroxyprostaglandin dehydrogenase messenger RNA concentration, protein expression, and enzymatic activity during human ureteral obstruction. (14718596)
2004
32
Smad3 deficiency attenuates renal fibrosis, inflammation,and apoptosis after unilateral ureteral obstruction. (15253712)
2004
33
Acatalasemia sensitizes renal tubular epithelial cells to apoptosis and exacerbates renal fibrosis after unilateral ureteral obstruction. (14722014)
2004
34
Schistosomiasis--an unusual cause of ureteral obstruction: a case history and perspective. (15931361)
2004
35
Effects of mycophenolate mofetil on renal interstitial fibrosis after Unilateral ureteral obstruction in rats. (14526430)
2003
36
LIMP-2/LGP85 deficiency causes ureteric pelvic junction obstruction, deafness and peripheral neuropathy in mice. (12620969)
2003
37
Resistive index: an experimental study of acute complete unilateral ureteral obstruction. (12595795)
2003
38
Palliative Subcutaneous Tunneled Nephrostomy Tube (PSTN): a simple and effective technique for management of malignant extrinsic ureteral obstruction. (11886602)
2002
39
Prospective evaluation of ureteral stent durability in patients with chronic ureteral obstruction. (12031366)
2002
40
Long-term results of ileum interposition for ureteral obstruction. (12160591)
2002
41
Ureteral and sigmoid obstruction caused by pelvic actinomycosis in an intrauterine contraceptive device user. (12592067)
2002
42
Does cyclooxygenase-2 inhibitor prevent renal tissue damage in unilateral ureteral obstruction? (11490310)
2001
43
Nephrogenic adenoma associated with cytomegalovirus infection of the ureter in a renal transplant patient: presentation as ureteral obstruction. (11370164)
2001
44
Urethral obstruction and bilateral ureteral hydronephroses secondary to fecal impaction. (10777196)
2000
45
Polyamine oxidase and diamine oxidase activities in acute ureteral obstruction. (9678451)
1998
46
Bilateral ureteral obstruction downregulates expression of vasopressin-sensitive AQP-2 water channel in rat kidney. (8967344)
1996
47
Bilateral obstructing ureteral uric acid stones in an infant with hereditary renal hypouricemia. (8501797)
1993
48
A new approach to ureteral obstruction and pelvic lipomatosis. (7276698)
1981
49
Reflex anuria from unilateral ureteral obstruction. (7354536)
1980
50
Clinicopathological conference: Hepatic coma and ureteral obstruction. (5528015)
1970

Genetic Variations for Ureteral Obstruction

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Expression for genes affiliated with Ureteral Obstruction

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Ureteral Obstruction

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Pathways for genes affiliated with Ureteral Obstruction

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51QIAGEN, 53Reactome, 49PharmGKB, 37NCBI BioSystems Database
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Compounds for genes affiliated with Ureteral Obstruction

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28IUPHAR, 44Novoseek, 11DrugBank, 49PharmGKB, 59Tocris Bioscience, 24HMDB
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Compounds related to Ureteral Obstruction according to GeneCards/GeneDecks:

(show all 50)
idCompoundScoreTop Affiliating Genes
1angiotensin iii2810.7AGTR2, AGTR1
2angiotensin i2810.7AGTR2, AGTR1
3etoperidone4410.7AGTR2, AGTR1
413,14-dihydro-15-keto-pge24410.7HPGD, PTGS1
5Tasosartan1110.7AGTR1, AGTR2
6cgp42112a4410.6AGTR1, AGTR2
7pge24410.6AQP2, TGFB1
8irbesartan44 28 49 1113.6PTGS1, AGTR1, AGTR2
9cyclosporin a44 28 5912.6AQP2, AMBP
10saralasin4410.6AGTR1, AGTR2
11candesartan44 28 1112.6AGTR2, AGTR1, PTGS1, TGFB1
12angiotensin ii28 2411.6AGTR1, AGTR2
13ang ii4410.6AGTR2, AGTR1, TGFB1
14mercury4410.6AMBP, AQP3, AQP2
15deoxyribonucleic acid4410.5BMP7, AGTR1, CLU
16benazepril44 1111.5TGFB1, AGTR1
17enalapril44 49 1112.5AGTR1, AGTR2, BMP7, AMBP
18losartan44 49 28 1113.5TGFB1, AGTR1, AGTR2, PDGFA
19pd12331944 2811.5AGTR2, AGTR1
20hgcl24410.5AQP2, AQP3
21agarose4410.5AMBP, BMP7, CLU, TGFB1
22hg2+2810.4AQP3, AQP2
23tgf beta14410.4PDGFA, BMP7, AGTR1, ADAMTS1, TGFB1
24ribonucleic acid4410.4PDGFA, BMP7, HPGD, CLU, TGFB1
25ethanol44 49 11 2413.4FABP1, BMP7, AGTR2, AGTR1, CLU
26calcitriol44 59 11 2413.4SFRP4, BMP7, HPGD, CLU, TGFB1
27arachidonic acid44 28 11 2413.4PTGS1, HPGD, AGTR1, AGTR2, FABP1
28inulin4410.3AMBP, CLU
29prostaglandin4410.3AMBP, AGTR2, AGTR1, HPGD, PTGS1, AQP2
30cisplatin44 49 59 1113.3AMBP, AGTR1, CLU, AQP2, TGFB1
31vitamin d4410.3PDGFA, BMP7, AGTR1, HPGD, CLU, PTGS1
32cycloheximide4410.3PDGFA, BMP7, AGTR2, AGTR1, CLU, PTGS1
33vegf4410.2PDGFA, FABP1, BMP7, AGTR1, CLU, PTGS1
34sodium44 2411.2AMBP, SFRP4, AGTR2, AGTR1, AQP2
35heparin44 28 11 2413.2PDGFA, BMP7, AGTR1, CLU, ADAMTS1
36sodium nitroprusside4410.2TGFB1, PTGS1, AGTR1
37indomethacin44 59 28 1113.2TGFB1, PTGS1, HPGD, AGTR2
38alanine4410.2AMBP, AGTR2, AGTR1, HPGD, PTGS1, AQP2
39threonine4410.2BMP7, MAP3K12, HPGD, AQP3, AQP2, TGFB1
40silver4410.2AQP3, AGTR1, AMBP
41progesterone44 59 28 11 2414.2SFRP4, PDGFA, BMP7, HPGD, CLU, ADAMTS1
42glucose4410.2AMBP, FABP1, BMP7, DCXR, AGTR1, AQP3
43creatinine4410.1AMBP, FABP1, BMP7, AGTR2, AGTR1, AQP3
44dexamethasone44 49 28 1113.1TGFB1, PDGFA, FABP1, BMP7, HPGD, CLU
45oxygen44 2411.1PDGFA, BMP7, AGTR2, AGTR1, CLU, PTGS1
46retinoic acid44 2411.1AMBP, PDGFA, FABP1, BMP7, MAP3K12, CLU
47methionine4410.0AMBP, FABP1, HPGD, AQP2
48calcium44 49 11 2412.9AMBP, SFRP4, PDGFA, BMP7, AGTR2, AGTR1
49serine449.8AMBP, BMP7, AGTR1, MAP3K12, HPGD, CLU
50cysteine449.6AMBP, AGTR1, HPGD, CLU, PTGS1, AQP2

GO Terms for genes affiliated with Ureteral Obstruction

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16Gene Ontology
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Cellular components related to Ureteral Obstruction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1microvillusGO:00590210.1TGFB1, PDGFA, DCXR
2platelet alpha granule lumenGO:0310939.9CLU, TGFB1, PDGFA
3extracellular spaceGO:0056159.8AMBP, SFRP4, PDGFA, BMP7, CLU, TGFB1

Biological processes related to Ureteral Obstruction according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1renin-angiotensin regulation of aldosterone productionGO:00201810.5AGTR1, AGTR2
2cellular response to dexamethasone stimulusGO:07154910.5TGFB1, AGTR2
3negative regulation of immune responseGO:05077710.5AMBP, TGFB1
4negative regulation of cell cycleGO:04578610.4TGFB1, BMP7, HPGD
5positive regulation of cellular protein metabolic processGO:03227010.4TGFB1, AGTR1
6platelet degranulationGO:00257610.4PDGFA, TGFB1, CLU
7response to vitamin DGO:03328010.3AQP3, TGFB1
8female pregnancyGO:00756510.3TGFB1, AMBP, HPGD, AQP2
9negative regulation of blood vessel endothelial cell migrationGO:04353710.3TGFB1, AGTR2
10positive regulation of apoptotic processGO:04306510.2CLU, SFRP4, BMP7, TGFB1
11positive regulation of peptidyl-threonine phosphorylationGO:01080010.2TGFB1, BMP7
12embryo developmentGO:00979010.1PDGFA, TGFB1, SFRP4
13cyclooxygenase pathwayGO:01937110.0HPGD, PTGS1

Molecular functions related to Ureteral Obstruction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1angiotensin type II receptor activityGO:00494510.0AGTR1, AGTR2
2protein homodimerization activityGO:0428039.9TGFB1, HPGD, MAP3K12, PDGFA, AMBP

Products for genes affiliated with Ureteral Obstruction

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Sources for Ureteral Obstruction

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet