Aliases & Classifications for Ureteral Obstruction

MalaCards integrated aliases for Ureteral Obstruction:

Name: Ureteral Obstruction 12 52 14

External Ids:

Disease Ontology 12 DOID:5199
ICD9CM 35 593.4
SNOMED-CT 64 197807001
UMLS 69 C0029866

Summaries for Ureteral Obstruction

MalaCards based summary : Ureteral Obstruction is related to ovarian remnant syndrome and 12q15q21.1 microdeletion syndrome. An important gene associated with Ureteral Obstruction is TGFB1 (Transforming Growth Factor Beta 1), and among its related pathways/superpathways are PEDF Induced Signaling and TGF-Beta Pathway. The drugs Tamsulosin and Silodosin have been mentioned in the context of this disorder. Affiliated tissues include kidney, endothelial and bone, and related phenotypes are Increased shRNA abundance (Z-score > 2) and cardiovascular system

Related Diseases for Ureteral Obstruction

Diseases related to Ureteral Obstruction via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 129)
id Related Disease Score Top Affiliating Genes
1 ovarian remnant syndrome 28.7 PTGS1 PTGS2
2 12q15q21.1 microdeletion syndrome 10.8 AGTR2 TGFB1
3 primary microcephaly-mild intellectual disability-young-onset diabetes syndrome 10.7 IL10 TGFB1
4 pulmonary valve insufficiency 10.6 AQP2 BMP7 TGFB1
5 pulpitis 10.5 AQP2 SLC12A1 TGFB1
6 chronic inflammatory demyelinating polyradiculoneuropathy 10.5 AQP2 PTGS2 TGFB1
7 potato nose 10.5 AGTR1 AGTR2 TGFB1
8 renal fibrosis 10.5
9 glycogen storage disease due to lactate dehydrogenase deficiency 10.5 CTNNB1 TP53
10 episodic ataxia 10.4 AGTR1 AGTR2 TGFB1
11 calcinosis 10.4 AQP2 EPO TGFB1
12 exocrine pancreatic insufficiency 10.4 AGTR1 EPO TGFB1
13 tendon sheath lipoma 10.4 PTGS2 TP53
14 atrophy of prostate 10.3 IL10 SLC12A1 SLC9A3
15 detrusor sphincter dyssynergia 10.3 IL10 NOS2 TGFB1
16 breast myoepithelial neoplasm 10.3 CTNNB1 TP53
17 clitoris cancer 10.3 AGTR1 EPO
18 discoid lupus erythematosus of eyelid 10.3 IL10 NOS2 TGFB1
19 conjunctival concretion 10.2 PTGS2 TGFB1 TP53
20 rectum kaposi's sarcoma 10.2 CTNNB1 PTGS2 TP53
21 gastrointestinal neuroendocrine tumor 10.2 CTNNB1 PTGS2 TP53
22 maxillary neoplasm 10.2 CTNNB1 PTGS2 TP53
23 congenital hypomyelination neuropathy 10.2 CTNNB1 PTGS2 TP53
24 arteritic anterior ischemic optic neuropathy 10.2 CTNNB1 PTGS2 TP53
25 hypertension, essential 10.1 AGTR1 AGTR2 NOS2 SLC12A1
26 hydronephrosis 10.1
27 retroperitoneal fibrosis 10.1
28 gallbladder cancer 10.1 CTNNB1 PTGS2 TP53
29 craniosynostosis 10.1 AGTR1 AQP2 EPO
30 strawberry gallbladder 10.1 BMP6 IL10 TGFB1
31 anuria 10.0
32 nail disorder, nonsyndromic congenital, 1 10.0 CTNNB1 PTGS2 TP53
33 aneurysm 10.0
34 vesicoureteral reflux 10.0
35 endotheliitis 10.0
36 perrault syndrome 10.0 AGTR1 BMP6 BMP7 TGFB1
37 acral lentiginous melanoma 10.0 EPO IL10 TP53
38 villous adenoma 9.9 CTNNB1 PTGS2 TP53
39 endometriosis 9.9
40 lipomatosis 9.9
41 pelvic lipomatosis 9.9
42 acute porphyria 9.9 CTNNB1 PTGS2 TP53
43 pulmonary artery hypoplasia 9.9 PTGS1 PTGS2 SLC12A1
44 pyelonephritis 9.9
45 aortic aneurysm 9.9
46 hypoxia 9.9
47 prostatitis 9.8
48 cystitis 9.8
49 ischemia 9.8
50 kidney disease 9.8

Graphical network of the top 20 diseases related to Ureteral Obstruction:



Diseases related to Ureteral Obstruction

Symptoms & Phenotypes for Ureteral Obstruction

GenomeRNAi Phenotypes related to Ureteral Obstruction according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.92 BMP7 IL10
2 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.92 PTGS1 TGFB1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-11 9.92 BMP7
4 Increased shRNA abundance (Z-score > 2) GR00366-A-113 9.92 IL10
5 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.92 TGFB1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-121 9.92 PTGS1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-125 9.92 IL10
8 Increased shRNA abundance (Z-score > 2) GR00366-A-128 9.92 IL10
9 Increased shRNA abundance (Z-score > 2) GR00366-A-132 9.92 IL10
10 Increased shRNA abundance (Z-score > 2) GR00366-A-137 9.92 PTGS1 BMP7
11 Increased shRNA abundance (Z-score > 2) GR00366-A-140 9.92 TGFB1
12 Increased shRNA abundance (Z-score > 2) GR00366-A-143 9.92 TGFB1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-152 9.92 IL10
14 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.92 IL10
15 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.92 TGFB1 PTGS1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.92 BMP7
17 Increased shRNA abundance (Z-score > 2) GR00366-A-178 9.92 TGFB1
18 Increased shRNA abundance (Z-score > 2) GR00366-A-198 9.92 TGFB1 BMP7 IL10 PTGS1
19 Increased shRNA abundance (Z-score > 2) GR00366-A-210 9.92 IL10
20 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.92 IL10
21 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.92 IL10
22 Increased shRNA abundance (Z-score > 2) GR00366-A-35 9.92 TGFB1
23 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.92 BMP7 IL10
24 Increased shRNA abundance (Z-score > 2) GR00366-A-56 9.92 TGFB1
25 Increased shRNA abundance (Z-score > 2) GR00366-A-67 9.92 IL10
26 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.92 BMP7
27 Increased shRNA abundance (Z-score > 2) GR00366-A-78 9.92 BMP7
28 Increased shRNA abundance (Z-score > 2) GR00366-A-80 9.92 IL10
29 Increased shRNA abundance (Z-score > 2) GR00366-A-82 9.92 IL10
30 Increased shRNA abundance (Z-score > 2) GR00366-A-83 9.92 BMP7
31 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.92 IL10
32 Increased shRNA abundance (Z-score > 2) GR00366-A-96 9.92 BMP7

MGI Mouse Phenotypes related to Ureteral Obstruction:

44 (show all 20)
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.42 AGTR1 AGTR2 BMP7 CLU CTNNB1 EPO
2 behavior/neurological MP:0005386 10.4 TGFB1 TP53 AGTR1 AGTR2 AQP2 BMP7
3 homeostasis/metabolism MP:0005376 10.39 AGTR1 AGTR2 AQP2 CLU CTNNB1 EPO
4 growth/size/body region MP:0005378 10.38 TP53 AGTR1 AGTR2 AQP2 BMP6 BMP7
5 hematopoietic system MP:0005397 10.34 AGTR1 AQP2 BMP7 CTNNB1 EPO HSPB1
6 immune system MP:0005387 10.31 AGTR1 BMP7 CLU CTNNB1 EPO HSPB1
7 cellular MP:0005384 10.27 TGFB1 TP53 AGTR2 CTNNB1 EPO HSPB1
8 digestive/alimentary MP:0005381 10.26 NOS2 PTGS1 PTGS2 SLC9A3 TGFB1 TP53
9 integument MP:0010771 10.26 PTGS2 SLC12A1 TGFB1 TP53 AGTR2 AQP2
10 endocrine/exocrine gland MP:0005379 10.25 AGTR2 BMP7 CTNNB1 IL10 NOS2 PTGS1
11 mortality/aging MP:0010768 10.25 PTGS1 PTGS2 SLC12A1 TGFB1 TP53 AGTR1
12 adipose tissue MP:0005375 10.14 AGTR1 AGTR2 NOS2 PTGS2 SLC9A3 TGFB1
13 muscle MP:0005369 10.1 AGTR2 CLU CTNNB1 EPO IL10 NOS2
14 renal/urinary system MP:0005367 10.07 NOS2 PTGS1 PTGS2 SLC12A1 SLC9A3 TGFB1
15 nervous system MP:0003631 10.06 AGTR1 AGTR2 BMP7 CLU CTNNB1 IL10
16 liver/biliary system MP:0005370 10 TP53 CTNNB1 EPO IL10 NOS2 PTGS2
17 neoplasm MP:0002006 9.97 PTGS2 TGFB1 TP53 AGTR2 CTNNB1 IL10
18 reproductive system MP:0005389 9.93 AQP2 BMP6 BMP7 CTNNB1 IL10 NOS2
19 respiratory system MP:0005388 9.61 BMP7 CTNNB1 EPO IL10 NOS2 PTGS1
20 skeleton MP:0005390 9.4 AGTR2 BMP6 BMP7 CTNNB1 EPO IL10

Drugs & Therapeutics for Ureteral Obstruction

Drugs for Ureteral Obstruction (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 49)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tamsulosin Approved, Investigational Phase 4,Phase 3 106133-20-4 129211
2
Silodosin Approved Phase 4 160970-54-7
3
Acetaminophen Approved Phase 4 103-90-2 1983
4 Mirabegron Approved Phase 4,Phase 2 223673-61-8
5 Central Nervous System Depressants Phase 4,Phase 2
6 Adrenergic Agents Phase 4,Phase 3,Phase 2
7 Adrenergic alpha-1 Receptor Antagonists Phase 4,Phase 3
8 Adrenergic alpha-Antagonists Phase 4,Phase 3
9 Adrenergic Antagonists Phase 4,Phase 3
10 Neurotransmitter Agents Phase 4,Phase 3,Phase 2
11 Peripheral Nervous System Agents Phase 4,Phase 2
12 Analgesics Phase 4
13 Acetaminophen, hydrocodone drug combination Phase 4
14 Adrenergic Agonists Phase 4,Phase 2
15 Adrenergic beta-3 Receptor Agonists Phase 4,Phase 2
16 Adrenergic beta-Agonists Phase 4,Phase 2
17 Narcotics Phase 4
18 Analgesics, Non-Narcotic Phase 4
19 Antipyretics Phase 4
20 Tolterodine tartrate Phase 4 124937-52-6
21 Cholinergic Agents Phase 4
22 Muscarinic Antagonists Phase 4
23 Cholinergic Antagonists Phase 4
24
Lidocaine Approved, Vet_approved Phase 2 137-58-6 3676
25
Triclosan Approved Phase 2 3380-34-5 5564
26
Gemcitabine Approved Phase 2 95058-81-4 60750
27
Iodine Investigational Phase 2 7553-56-2 807
28 Sodium Channel Blockers Phase 2
29 Anesthetics Phase 2
30 Anesthetics, Local Phase 2
31 Diuretics, Potassium Sparing Phase 2
32 Anti-Arrhythmia Agents Phase 2
33 Hypolipidemic Agents Phase 2
34 Anti-Infective Agents Phase 2
35 Anti-Infective Agents, Local Phase 2
36 Lipid Regulating Agents Phase 2
37 Antimetabolites Phase 2
38 Immunosuppressive Agents Phase 2
39 Antimetabolites, Antineoplastic Phase 2
40 Antiviral Agents Phase 2
41
Ropivacaine Approved 84057-95-4 71273 175805
42
Ibuprofen Approved 15687-27-1 3672
43
Nickel 7440-02-0 934
44 Cyclooxygenase Inhibitors
45 Anti-Inflammatory Agents
46 Anti-Inflammatory Agents, Non-Steroidal
47 Antirheumatic Agents
48 diuretics
49 Natriuretic Agents

Interventional clinical trials:

(show all 35)

id Name Status NCT ID Phase Drugs
1 Efficacy and Safety of a Covered Self-expandable Dual-layered Metallic Mesh Stent (UVENTA) in Ureteral Obstruction Unknown status NCT01788865 Phase 4
2 Functional MR Urography Completed NCT00301470 Phase 4
3 Efficacy and Safety of Silodosin in the Treatment of Natural Expulsion in Patients With Ureteral Stones Completed NCT01533389 Phase 4 Silodosin;Placebo
4 Ureteral Stent-related Pain and Mirabegron (SPAM) Trial Recruiting NCT02095665 Phase 4 Mirabegron;Tamsulosin;Tylenol #3
5 Treatment of Symptoms After Stent Placement for Urinary Tract Obstruction Active, not recruiting NCT01741454 Phase 4 Tamsulosin;Tolterodine ER
6 Evaluation of the Efficacy of Tamsulosin (Alpha Blockers) Compared to Phloroglucinol in Improving JJ Ureteral Stent Tolerance. A Randomized Controlled Trial Completed NCT01061073 Phase 3 Omexel;spasfon
7 Comparison of Silicone-covered Metallic Ureteral Stent and Double-J Stent for Malignant Ureteral Obstruction Unknown status NCT01823575 Phase 2
8 Tolerance and Effectiveness of Ureteral Stents MEMOKATH ® 051 in Chronic Strictures of the Ureter Completed NCT00790686 Phase 2
9 Assessment of Drug-eluting Ureteral Stent on Bacterial Adherence and Biofilm Formation Completed NCT00250406 Phase 2
10 A Randomized Control Trial Comparing Single vs. Multiple Application of Lidocaine Analgesia Prior to Urethral Catheterization Procedures Completed NCT00142064 Phase 2
11 Randomized Controlled Trial of Cystocele Plication Risks ("CPR Trial"): A Pilot Study Completed NCT01197248 Phase 2
12 Mirabegron as Medical Expulsive Therapy (MET) for Ureteral Stones and Ureteral Stent Pain Not yet recruiting NCT02744430 Phase 2 Mirabegron
13 Assessment of Gemcitabine as Chemoradiotherapy in Patients With Locally Advanced Carcinoma of Cervix and Renal Disease Not yet recruiting NCT03101995 Phase 2 Gemcitabine
14 The Correlation Between Renal Injury and Biomarkers in Pediatric Ureteropelvic Junction Obstruction Patients Unknown status NCT01711996
15 Ureteropelvic Junction Obstruction in Early Childhood: Comparison of Surgical Therapy and Surveillance. A Prospective, Randomized, Controlled Multi-Center Study Unknown status NCT00444431
16 A Prospective Comparison Between Ureteral Stent and Nephrostomy Tube for an Urgent Drainage of Obstructed Kidney Unknown status NCT00739284
17 Drainage of Malignant Extrinsic Ureteral Obstruction Using the Memokath Ureteral Stent Completed NCT00166361
18 Urinary Biomarkers as Predictors on Renal Function in Congenital Hydronephrosis Completed NCT00568724
19 Laparoscopic Pyeloplasty Registry and Database Completed NCT00169650
20 Evaluating Ureteral Length Using Computed Tomography (CT) Completed NCT01542593
21 The Efficacy and Safety of Local Anesthetic Infusion With Ropivacaine Completed NCT00930046
22 Dismembered Pyeloplasty With and Without After Coming Stent Completed NCT02138877
23 Uretal Flow Assessment During Gynecological Procedures Completed NCT00453882
24 Urinary Markers for Unilateral Kidney Obstruction Completed NCT01979042
25 Comparison of Two Position for Ultrasound Guided Lumbar Plexus and Sciatic Nerve Block Completed NCT00988234
26 Early Infancy Ureteral Reimplantation for Distal Ureteral Obstruction Recruiting NCT02419339
27 Indwelling Double-J Ureteral Stent Versus Externalized Modified-Salle Stent for Pyeloplasty Recruiting NCT02713633
28 Multi-Center Comparison of Dual Lumen Versus Single Lumen Ureteroscopes Recruiting NCT02123082
29 Randomized Trial of NSAID vs Placebo Prior to Ureteral Stent Removal Recruiting NCT02140970 Ibuprofen;Placebo
30 Indwelling Stent Discoloration Project Recruiting NCT02007980
31 Diagnostic Relevance of Laser Confocal Microscopy for the Screening of Upper Urinary Tract Tumors Active, not recruiting NCT02276924
32 Ureteral Reimplantation for the Treatment of Extrinsic Malignant Ureteral Obstruction Enrolling by invitation NCT02160652
33 The RELIEF™ Ureteral Stent - Assessment of Retrograde Urinary Reflux and Distal Coil Bladder Position Not yet recruiting NCT03266770
34 CTT on Renogram as an Early Marker of Significant Obstruction in Uretero-pelvic Junction Syndrome Not yet recruiting NCT02812212
35 Comparison of Dynamic Contrast Enhanced CT and Diuretic Renogram in The Evaluation of UPJO Withdrawn NCT00199472

Search NIH Clinical Center for Ureteral Obstruction

Genetic Tests for Ureteral Obstruction

Anatomical Context for Ureteral Obstruction

MalaCards organs/tissues related to Ureteral Obstruction:

39
Kidney, Endothelial, Bone, Cervix, Bone Marrow, Monocytes, Prostate

Publications for Ureteral Obstruction

Articles related to Ureteral Obstruction:

(show top 50) (show all 693)
id Title Authors Year
1
Macrophages Regulate Unilateral Ureteral Obstruction-Induced Renal Lymphangiogenesis through C-C Motif Chemokine Receptor 2-Dependent Phosphatidylinositol 3-Kinase-AKT-Mechanistic Target ofA Rapamycin Signaling and Hypoxia-Inducible Factor-1I+/Vascular Endothelial Growth Factor-C Expression. ( 28627412 )
2017
2
Kidney Injury due to Ureteral Obstruction Caused by Compression from Infected Simple Hepatic Cyst. ( 28626377 )
2017
3
Human Umbilical Cord-Derived Mesenchymal Stem Cells Conditioned Medium Attenuate Interstitial Fibrosis and Stimulate the Repair of Tubular Epithelial Cells in an Irreversible Model of Unilateral Ureteral Obstruction. ( 28667820 )
2017
4
Inhibition of Necroptosis Attenuates Kidney Inflammation and Interstitial Fibrosis Induced By Unilateral Ureteral Obstruction. ( 28723681 )
2017
5
Demethylzeylasteral ameliorates inflammation in a rat model of unilateral ureteral obstruction through inhibiting activation of the NFa89I_B pathway. ( 28534978 )
2017
6
TRAP1 ameliorates renal tubulointerstitial fibrosis in mice with unilateral ureteral obstruction by protecting renal tubular epithelial cell mitochondria. ( 28710113 )
2017
7
Lee AS, Lee JE, Jung YJ, etA al. Vascular endothelial growth factor-C and -D are involved in lymphangiogenesis in mouse unilateral ureteral obstruction. Kidney Int. 2013;83:50-62. ( 28938942 )
2017
8
Reactive oxygen species modulator 1 regulates oxidative stress and induces renal and pulmonary fibrosis in a unilateral ureteral obstruction rat model and in HKa892 cells. ( 28791399 )
2017
9
Sphingosine Kinase-2 Deficiency Ameliorates Kidney Fibrosis by Up-Regulating Smad7 in a Mouse Model of Unilateral Ureteral Obstruction. ( 28807595 )
2017
10
Intermedin inhibits unilateral ureteral obstruction-induced oxidative stress via NADPH oxidase Nox4 and cAMP-dependent mechanisms. ( 28805491 )
2017
11
Renal recruitment of B lymphocytes exacerbates tubulointerstitial fibrosis by promoting monocyte mobilization and infiltration after unilateral ureteral obstruction. ( 27763657 )
2017
12
Deficiency of mPGES-1 exacerbates renal fibrosis and inflammation in mice with unilateral ureteral obstruction. ( 27784694 )
2017
13
Fungal Bezoar: A Rare Cause of Ureteral Obstruction. ( 28804662 )
2017
14
Thymoquinone ameliorates renal damage in unilateral ureteral obstruction in rats. ( 28521173 )
2017
15
Notch signaling in the collecting duct regulates renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction in mice. ( 28602064 )
2017
16
Ethanol extract of gardenia fruit alleviates renal interstitial fibrosis induced by unilateral ureteral obstruction in rats. ( 28810600 )
2017
17
Mast Cells and MCPT4 Chymase Promote Renal Impairment after Partial Ureteral Obstruction. ( 28523000 )
2017
18
Retrograde pyelography predicts retrograde ureteral stenting failure and reduces unnecessary stenting trials in patients with advanced non-urological malignant ureteral obstruction. ( 28931043 )
2017
19
The bladder ran dry: bilateral ureteral obstruction. ( 28784872 )
2017
20
Intermedin attenuates renal fibrosis by induction of heme oxygenase-1 in rats with unilateral ureteral obstruction. ( 28697727 )
2017
21
Inguinal Bladder Hernia With Acute Ureteral Obstruction 14 Years After Kidney Transplantation: A Case Report. ( 28838448 )
2017
22
Breviscapine prevents downregulation of renal water and sodium transport proteins in response to unilateral ureteral obstruction. ( 27403265 )
2016
23
T-type calcium channel blocker attenuates unilateral ureteral obstruction-induced renal interstitial fibrosis by activating the Nrf2 antioxidant pathway. ( 27904663 )
2016
24
Ureteral obstruction secondary to disseminated penicilliosis in a German shepherd dog. ( 27928169 )
2016
25
CD11ca8_ CD8a8_ T Cells Reduce Renal Fibrosis Following Ureteric Obstruction by Inducing Fibroblast Apoptosis. ( 28025478 )
2016
26
CD39 overexpression does not attenuate renal fibrosis in the unilateral ureteric obstructive model of chronic kidney disease. ( 27565966 )
2016
27
A Curious Case of Ureteral Obstruction in a 15-Year-Old Female. ( 27449991 )
2016
28
Taking the STING Out of Ureteral Obstruction. ( 27785466 )
2016
29
Use of percutaneous nephrostomy and ureteral stenting in management of ureteral obstruction. ( 26981442 )
2016
30
Effects of exendin-4 on the intrarenal renin-angiotensin system and interstitial fibrosis in unilateral ureteral obstruction mice: Exendin-4 and unilateral ureteral obstruction. ( 27913661 )
2016
31
Screening and identification of the differentially expressed proteins in neonatal rat kidney after partial unilateral ureteral obstruction. ( 27222353 )
2016
32
Elsholtzia ciliata (Thunb.) Hylander attenuates renal inflammation and interstitial fibrosis via regulation of TGF-A9 and Smad3 expression on unilateral ureteral obstruction rat model. ( 27002403 )
2016
33
The study on serum and urine of renal interstitial fibrosis rats induced by unilateral ureteral obstruction based on metabonomics and network analysis methods. ( 26873208 )
2016
34
Piceatannol Attenuates Renal Fibrosis Induced by Unilateral Ureteral Obstruction via Downregulation of Histone Deacetylase 4/5 or p38-MAPK Signaling. ( 27902771 )
2016
35
Protective role of propofol on the kidney during early unilateral ureteral obstruction through inhibition of epithelial-mesenchymal transition. ( 27158339 )
2016
36
Mesenchymal Stromal Cells Prevent Renal Fibrosis in a Rat Model of Unilateral Ureteral Obstruction by Suppressing the Renin-Angiotensin System via HuR. ( 26866372 )
2016
37
Cells of renin lineage express hypoxia inducible factor 2I+ following experimental ureteral obstruction. ( 26746687 )
2016
38
Peroxisome proliferator-activated receptor-I^ agonist pioglitazone fails to attenuate renal fibrosis caused by unilateral ureteral obstruction in mice. ( 26838738 )
2016
39
Regulation of eIF2I+ expression and renal interstitial fibrosis by resveratrol in rat renal tissue after unilateral ureteral obstruction. ( 26923138 )
2016
40
A porcine model of relief of unilateral ureteral obstruction: study on self-repairing capability over multiple time points. ( 27381184 )
2016
41
SREBP inhibition ameliorates renal injury after unilateral ureteral obstruction. ( 27385736 )
2016
42
The Protective Effect of Melittin on Renal Fibrosis in an Animal Model of Unilateral Ureteral Obstruction. ( 27618890 )
2016
43
Metabolomics study of renal fibrosis and intervention effects of total aglycone extracts of Scutellaria baicalensis in unilateral ureteral obstruction rats. ( 27286917 )
2016
44
Artesunate attenuates unilateral ureteral obstruction-induced renal fibrosis by regulating the expressions of bone morphogenetic protein-7 and uterine sensitization-associated gene-1 in rats. ( 26865179 )
2016
45
Outcomes of patients with ureteral obstruction who achieved stent-free state following balloon dilatation. ( 27603427 )
2016
46
Downregulation of angiotensin type 1 receptor and nuclear factor-I_B by sirtuin 1 contributes to renoprotection in unilateral ureteral obstruction. ( 27659793 )
2016
47
Persistent activation of autophagy in kidney tubular cells promotes renal interstitial fibrosis during unilateral ureteral obstruction. ( 27123926 )
2016
48
A high affinity kidney targeting by chitobionic acid-conjugated polysorbitol gene transporter alleviates unilateral ureteral obstruction in rats. ( 27318934 )
2016
49
Nitric oxide and asymmetric dimethyl arginine (ADMA) levels in an experimental hydronephrotic kidney caused by unilateral partial ureteral obstruction. ( 27286129 )
2016
50
Placement of subcutaneous ureteral bypasses without fluoroscopic guidance in cats with ureteral obstruction: 19 cases (2014-2016). ( 27694368 )
2016

Variations for Ureteral Obstruction

Expression for Ureteral Obstruction

Search GEO for disease gene expression data for Ureteral Obstruction.

Pathways for Ureteral Obstruction

Pathways related to Ureteral Obstruction according to GeneCards Suite gene sharing:

(show all 25)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.54 BMP6 BMP7 EPO IL10 NOS2 PTGS1
2
Show member pathways
13.4 AGTR1 AGTR2 BMP6 BMP7 EPO HSPB1
3
Show member pathways
12.94 AGTR1 AGTR2 BMP6 BMP7 PTGS2 TGFB1
4 12.48 AGTR1 CTNNB1 NOS2 PTGS2 TGFB1 TP53
5
Show member pathways
12.45 AGTR1 CTNNB1 IL10 NOS2 TP53
6
Show member pathways
12.25 CTNNB1 HSPB1 NOS2 PTGS1 PTGS2
7
Show member pathways
12.14 IL10 NOS2 PTGS2 TGFB1
8 12.12 BMP6 BMP7 CTNNB1 TGFB1
9 12.02 BMP6 BMP7 CTNNB1 TGFB1
10 11.98 CTNNB1 NOS2 PTGS2 TGFB1 TP53
11 11.87 NOS2 PTGS2 TGFB1 TP53
12 11.78 BMP6 BMP7 TGFB1
13 11.72 HSPB1 IL10 NOS2 TGFB1
14 11.71 NOS2 PTGS2 TP53
15 11.71 BMP6 BMP7 TGFB1
16 11.71 IL10 NOS2 PTGS2 TGFB1 TP53
17 11.62 IL10 NOS2 TGFB1
18 11.58 BMP6 BMP7 TGFB1
19 11.52 CTNNB1 PTGS1 PTGS2
20 11.33 NOS2 PTGS2 TGFB1 TP53
21 11.18 BMP6 BMP7 CTNNB1 HSPB1 TGFB1 TP53
22 11.1 NOS2 PTGS1 PTGS2
23 11.02 EPO NOS2 PTGS2 TP53
24 10.8 PTGS1 PTGS2
25 10.8 HSPB1 NOS2 PTGS2 TP53

GO Terms for Ureteral Obstruction

Biological processes related to Ureteral Obstruction according to GeneCards Suite gene sharing:

(show all 39)
id Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.95 EPO HSPB1 IL10 TP53
2 positive regulation of apoptotic process GO:0043065 9.95 BMP7 CTNNB1 PTGS2 TGFB1 TP53
3 response to lipopolysaccharide GO:0032496 9.89 EPO IL10 NOS2 PTGS2
4 aging GO:0007568 9.88 EPO IL10 PTGS2 TGFB1
5 response to organic substance GO:0010033 9.85 IL10 PTGS2 TGFB1
6 negative regulation of cell proliferation GO:0008285 9.85 BMP7 CTNNB1 IL10 PTGS2 TGFB1 TP53
7 BMP signaling pathway GO:0030509 9.84 BMP6 BMP7 TGFB1
8 positive regulation of neuron differentiation GO:0045666 9.83 BMP6 BMP7 EPO
9 cellular response to mechanical stimulus GO:0071260 9.81 BMP6 PTGS2 TGFB1
10 negative regulation of cell death GO:0060548 9.8 BMP7 CLU CTNNB1
11 response to glucocorticoid GO:0051384 9.79 BMP6 IL10 PTGS2
12 regulation of blood pressure GO:0008217 9.78 AGTR2 PTGS1 PTGS2
13 SMAD protein signal transduction GO:0060395 9.77 BMP6 BMP7 TGFB1
14 positive regulation of osteoblast differentiation GO:0045669 9.76 BMP6 BMP7 CTNNB1
15 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 9.73 BMP6 BMP7 TGFB1
16 kidney development GO:0001822 9.73 AGTR1 BMP6 BMP7 CTNNB1
17 inflammatory response GO:0006954 9.73 AGTR2 BMP6 IL10 PTGS1 PTGS2 TGFB1
18 response to estradiol GO:0032355 9.71 BMP7 CTNNB1 PTGS2 TGFB1
19 positive regulation of nitric oxide biosynthetic process GO:0045429 9.7 AGTR2 CLU PTGS2
20 positive regulation of transcription, DNA-templated GO:0045893 9.7 AGTR2 BMP7 CTNNB1 EPO IL10 TGFB1
21 prostaglandin biosynthetic process GO:0001516 9.68 PTGS1 PTGS2
22 positive regulation of endothelial cell differentiation GO:0045603 9.68 BMP6 CTNNB1
23 negative regulation of cell cycle GO:0045786 9.67 BMP7 PTGS2 TGFB1
24 positive regulation of SMAD protein import into nucleus GO:0060391 9.66 BMP6 TGFB1
25 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.66 BMP7 IL10
26 epithelial to mesenchymal transition GO:0001837 9.65 BMP7 CTNNB1 TGFB1
27 positive regulation of histone deacetylation GO:0031065 9.64 TGFB1 TP53
28 cyclooxygenase pathway GO:0019371 9.64 PTGS1 PTGS2
29 salivary gland morphogenesis GO:0007435 9.63 BMP7 TGFB1
30 positive regulation of bone mineralization GO:0030501 9.63 BMP6 BMP7 TGFB1
31 angiotensin-activated signaling pathway GO:0038166 9.62 AGTR1 AGTR2
32 negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress GO:1902219 9.57 EPO PTGS2
33 positive regulation of epithelial to mesenchymal transition GO:0010718 9.54 CTNNB1 TGFB1
34 renin-angiotensin regulation of aldosterone production GO:0002018 9.51 AGTR1 AGTR2
35 response to vitamin D GO:0033280 9.5 BMP7 PTGS2 TGFB1
36 regulation of apoptotic process GO:0042981 9.43 AGTR2 BMP6 BMP7 CTNNB1 TGFB1 TP53
37 regulation of blood vessel diameter GO:0097746 9.37 AGTR1
38 regulation of cell proliferation GO:0042127 9.1 AGTR1 CTNNB1 NOS2 PTGS1 PTGS2 TGFB1
39 positive regulation of cell proliferation GO:0008284 10.05 AGTR2 CTNNB1 EPO PTGS2 TGFB1

Molecular functions related to Ureteral Obstruction according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein heterodimerization activity GO:0046982 9.8 AGTR1 BMP6 CTNNB1 TGFB1 TP53
2 cytokine activity GO:0005125 9.62 BMP6 BMP7 IL10 TGFB1
3 growth factor activity GO:0008083 9.56 BMP6 BMP7 IL10 TGFB1
4 BMP receptor binding GO:0070700 9.37 BMP6 BMP7
5 transforming growth factor beta receptor binding GO:0005160 9.33 BMP6 BMP7 TGFB1
6 angiotensin type II receptor activity GO:0004945 8.96 AGTR1 AGTR2
7 prostaglandin-endoperoxide synthase activity GO:0004666 8.62 PTGS1 PTGS2

Sources for Ureteral Obstruction

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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