Aliases & Classifications for Ureteral Obstruction

MalaCards integrated aliases for Ureteral Obstruction:

Name: Ureteral Obstruction 12 51 14

External Ids:

Disease Ontology 12 DOID:5199
ICD9CM 34 593.4
SNOMED-CT 64 197807001
UMLS 69 C0029866

Summaries for Ureteral Obstruction

MalaCards based summary : Ureteral Obstruction is related to renal fibrosis and hydronephrosis. An important gene associated with Ureteral Obstruction is TGFB1 (Transforming Growth Factor Beta 1), and among its related pathways/superpathways are ERK Signaling and PEDF Induced Signaling. The drugs Silodosin and Tamsulosin have been mentioned in the context of this disorder. Affiliated tissues include kidney, endothelial and bone, and related phenotypes are cardiovascular system and homeostasis/metabolism

Related Diseases for Ureteral Obstruction

Diseases related to Ureteral Obstruction via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 147)
# Related Disease Score Top Affiliating Genes
1 renal fibrosis 30.9 AGTR1 BMP6 BMP7 TGFB1
2 hydronephrosis 30.8 AQP2 SLC12A1 TGFB1
3 esophagitis 29.5 PTGS2 TGFB1 TP53
4 familial adenomatous polyposis 28.6 CTNNB1 PTGS2 TP53
5 fibrosis of extraocular muscles, congenital, 1 10.7
6 juvenile myasthenia gravis 10.4 IL10 TGFB1
7 ureteral disease 10.4 AQP2 BMP7 TGFB1
8 familial vesicoureteral reflux 10.4 AGTR2 TGFB1
9 urinary tract obstruction 10.3 AQP2 PTGS2 TGFB1
10 posterior urethral valves 10.3 AGTR1 AGTR2 TGFB1
11 end stage renal failure 10.3 AGTR1 EPO TGFB1
12 leptospirosis 10.2 IL10 SLC12A1 SLC9A3
13 leukoregulin 10.2 PTGS2 TGFB1
14 retroperitoneal fibrosis 10.2
15 autoinflammation, lipodystrophy, and dermatosis syndrome 10.2 IL10 NOS2 PTGS2
16 chagas disease 10.2 IL10 NOS2 TGFB1
17 adult hepatocellular carcinoma 10.1 CTNNB1 TP53
18 protoplasmic astrocytoma 10.1 PTGS2 TP53
19 anuria 10.1
20 fanconi-like syndrome 10.1 LRP2 PTGS2
21 aneurysm 10.1
22 endotheliitis 10.1
23 tuberculoid leprosy 10.1 BMP6 IL10 TGFB1
24 squamous cell carcinoma of the oropharynx 10.1 IL10 TP53
25 leishmaniasis 10.1 IL10 NOS2 TGFB1
26 vesicoureteral reflux 1 10.1
27 blood group, i system 10.0
28 endometriosis 10.0
29 urinary system disease 10.0 AQP2 EPO LRP2 TGFB1
30 uterine carcinosarcoma 10.0 CTNNB1 PTGS2 TP53
31 gastrointestinal system benign neoplasm 10.0 CTNNB1 PTGS2 TP53
32 hypertension, essential 10.0 AGTR1 AGTR2 NOS2 SLC12A1
33 intestinal benign neoplasm 10.0 CTNNB1 PTGS2 TP53
34 fibrosclerosis, multifocal 10.0
35 lipomatosis 10.0
36 pelvic lipomatosis 10.0
37 colorectal adenoma 9.9 CTNNB1 PTGS2 TP53
38 pyelonephritis 9.9
39 cystitis 9.9
40 aortic aneurysm 9.9
41 hypoxia 9.9
42 colorectal adenocarcinoma 9.9 CTNNB1 PTGS2 TP53
43 tongue squamous cell carcinoma 9.9 CTNNB1 TP53 VEGFC
44 tongue cancer 9.9 CTNNB1 TP53 VEGFC
45 aortic aneurysm, familial abdominal, 1 9.9
46 chronic kidney failure 9.9
47 prostatitis 9.9
48 ischemia 9.9
49 kidney disease 9.9
50 renal dysplasia 9.9

Graphical network of the top 20 diseases related to Ureteral Obstruction:



Diseases related to Ureteral Obstruction

Symptoms & Phenotypes for Ureteral Obstruction

MGI Mouse Phenotypes related to Ureteral Obstruction:

43 (show all 24)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.51 LRP2 CTNNB1 AGTR1 NOX4 BMP7 NOS2
2 homeostasis/metabolism MP:0005376 10.44 LRP2 AQP2 CTNNB1 AGTR1 NOX4 NOS2
3 growth/size/body region MP:0005378 10.43 LRP2 AQP2 AGTR1 BMP6 NOX4 BMP7
4 behavior/neurological MP:0005386 10.39 BMP7 AGTR2 NOS2 LRP2 AQP2 AGTR1
5 hematopoietic system MP:0005397 10.36 BMP7 NOS2 LRP2 AQP2 AGTR1 IL10
6 mortality/aging MP:0010768 10.35 BMP7 AGTR2 NOS2 LRP2 AQP2 AGTR1
7 cellular MP:0005384 10.34 AGTR2 NOS2 LRP2 NOX4 IL10 EPO
8 immune system MP:0005387 10.34 BMP7 NOS2 LRP2 AGTR1 SLC12A1 IL10
9 digestive/alimentary MP:0005381 10.28 AGTR2 NOS2 LRP2 BMP7 IL10 PTGS2
10 endocrine/exocrine gland MP:0005379 10.27 BMP7 AGTR2 NOS2 LRP2 IL10 SLC9A3
11 integument MP:0010771 10.25 NOS2 AQP2 BMP7 AGTR2 IL10 PTGS2
12 embryo MP:0005380 10.18 IL10 BMP7 LRP2 CTNNB1 EPO PTGS2
13 adipose tissue MP:0005375 10.16 AGTR2 NOS2 AGTR1 SLC9A3 PTGS2 TP53
14 craniofacial MP:0005382 10.14 BMP7 NOS2 LRP2 IL10 CTNNB1 TGFB1
15 nervous system MP:0003631 10.14 BMP7 AGTR2 NOS2 LRP2 AGTR1 NOX4
16 renal/urinary system MP:0005367 10.13 LRP2 AQP2 CTNNB1 AGTR1 NOX4 BMP7
17 muscle MP:0005369 10.11 AGTR2 NOS2 NOX4 IL10 PTGS2 EPO
18 liver/biliary system MP:0005370 10.04 IL10 NOS2 CTNNB1 EPO PTGS2 TGFB1
19 reproductive system MP:0005389 10.03 LRP2 AQP2 BMP6 BMP7 NOS2 PTGS2
20 neoplasm MP:0002006 9.98 AGTR2 NOS2 IL10 PTGS2 CTNNB1 TP53
21 no phenotypic analysis MP:0003012 9.91 IL10 LRP2 NOX4 CTNNB1 PTGS2 HSPB1
22 respiratory system MP:0005388 9.85 LRP2 NOX4 BMP7 NOS2 PTGS2 EPO
23 skeleton MP:0005390 9.73 LRP2 BMP6 BMP7 AGTR2 NOS2 PTGS2
24 vision/eye MP:0005391 9.23 BMP7 NOS2 LRP2 IL10 CTNNB1 PTGS2

Drugs & Therapeutics for Ureteral Obstruction

Drugs for Ureteral Obstruction (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 45)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Silodosin Approved Phase 4 160970-54-7
2
Tamsulosin Approved, Investigational Phase 4 106133-20-4 129211
3 Adrenergic Agents Phase 4,Phase 2
4 Adrenergic alpha-1 Receptor Antagonists Phase 4
5 Adrenergic alpha-Antagonists Phase 4
6 Adrenergic Antagonists Phase 4
7 Neurotransmitter Agents Phase 4,Phase 2
8 Cholinergic Agents Phase 4
9 Cholinergic Antagonists Phase 4
10 Muscarinic Antagonists Phase 4
11 Tolterodine tartrate Phase 4 124937-52-6
12
Iodine Approved, Investigational Phase 2 7553-56-2 807
13
Triclosan Approved, Investigational Phase 2 3380-34-5 5564
14
Lidocaine Approved, Vet_approved Phase 2 137-58-6 3676
15 Mirabegron Approved Phase 2 223673-61-8
16
Gemcitabine Approved Phase 2 95058-81-4 60750
17 Anesthetics Phase 2
18 Anti-Infective Agents Phase 2
19 Anti-Infective Agents, Local Phase 2
20 Antimetabolites Phase 2
21 Hypolipidemic Agents Phase 2
22 Lipid Regulating Agents Phase 2
23 Anesthetics, Local Phase 2
24 Anti-Arrhythmia Agents Phase 2
25 Central Nervous System Depressants Phase 2
26 Diuretics, Potassium Sparing Phase 2
27 Peripheral Nervous System Agents Phase 2
28 Sodium Channel Blockers Phase 2
29 Adrenergic Agonists Phase 2
30 Adrenergic beta-3 Receptor Agonists Phase 2
31 Adrenergic beta-Agonists Phase 2
32 Antimetabolites, Antineoplastic Phase 2
33 Antiviral Agents Phase 2
34 Immunosuppressive Agents Phase 2
35
Ropivacaine Approved 84057-95-4 175805 71273
36
Ibuprofen Approved 15687-27-1 3672
37
Nickel 7440-02-0 934
38 Analgesics
39 Analgesics, Non-Narcotic
40 Anti-Inflammatory Agents
41 Anti-Inflammatory Agents, Non-Steroidal
42 Antirheumatic Agents
43 Cyclooxygenase Inhibitors
44 diuretics
45 Natriuretic Agents

Interventional clinical trials:

(show all 28)

# Name Status NCT ID Phase Drugs
1 Efficacy and Safety of a Covered Self-expandable Dual-layered Metallic Mesh Stent (UVENTA) in Ureteral Obstruction Unknown status NCT01788865 Phase 4
2 Functional MR Urography Completed NCT00301470 Phase 4
3 Efficacy and Safety of Silodosin in the Treatment of Natural Expulsion in Patients With Ureteral Stones Completed NCT01533389 Phase 4 Silodosin;Placebo
4 Treatment of Symptoms After Stent Placement for Urinary Tract Obstruction Active, not recruiting NCT01741454 Phase 4 Tamsulosin;Tolterodine ER
5 Comparison of Silicone-covered Metallic Ureteral Stent and Double-J Stent for Malignant Ureteral Obstruction Unknown status NCT01823575 Phase 2
6 Tolerance and Effectiveness of Ureteral Stents MEMOKATH ® 051 in Chronic Strictures of the Ureter Completed NCT00790686 Phase 2
7 Assessment of Drug-eluting Ureteral Stent on Bacterial Adherence and Biofilm Formation Completed NCT00250406 Phase 2
8 A Randomized Control Trial Comparing Single vs. Multiple Application of Lidocaine Analgesia Prior to Urethral Catheterization Procedures Completed NCT00142064 Phase 2
9 Randomized Controlled Trial of Cystocele Plication Risks ("CPR Trial"): A Pilot Study Completed NCT01197248 Phase 2
10 Mirabegron as Medical Expulsive Therapy (MET) for Ureteral Stones and Ureteral Stent Pain Not yet recruiting NCT02744430 Phase 2 Mirabegron
11 Assessment of Gemcitabine as Chemoradiotherapy in Patients With Locally Advanced Carcinoma of Cervix and Renal Disease Not yet recruiting NCT03101995 Phase 2 Gemcitabine
12 The Correlation Between Renal Injury and Biomarkers in Pediatric Ureteropelvic Junction Obstruction Patients Unknown status NCT01711996
13 Ureteropelvic Junction Obstruction in Early Childhood: Comparison of Surgical Therapy and Surveillance. A Prospective, Randomized, Controlled Multi-Center Study Unknown status NCT00444431
14 Drainage of Malignant Extrinsic Ureteral Obstruction Using the Memokath Ureteral Stent Completed NCT00166361
15 Urinary Biomarkers as Predictors on Renal Function in Congenital Hydronephrosis Completed NCT00568724
16 Laparoscopic Pyeloplasty Registry and Database Completed NCT00169650
17 Evaluating Ureteral Length Using Computed Tomography (CT) Completed NCT01542593
18 The Efficacy and Safety of Local Anesthetic Infusion With Ropivacaine Completed NCT00930046
19 Dismembered Pyeloplasty With and Without After Coming Stent Completed NCT02138877
20 Early Infancy Ureteral Reimplantation for Distal Ureteral Obstruction Recruiting NCT02419339
21 Multi-Center Comparison of Dual Lumen Versus Single Lumen Ureteroscopes Recruiting NCT02123082
22 Indwelling Double-J Ureteral Stent Versus Externalized Modified-Salle Stent for Pyeloplasty Recruiting NCT02713633
23 Randomized Trial of NSAID vs Placebo Prior to Ureteral Stent Removal Recruiting NCT02140970 Ibuprofen;Placebo
24 Diagnostic Relevance of Laser Confocal Microscopy for the Screening of Upper Urinary Tract Tumors Active, not recruiting NCT02276924
25 Ureteral Reimplantation for the Treatment of Extrinsic Malignant Ureteral Obstruction Enrolling by invitation NCT02160652
26 The RELIEF™ Ureteral Stent - Assessment of Retrograde Urinary Reflux and Distal Coil Bladder Position Not yet recruiting NCT03266770
27 CTT on Renogram as an Early Marker of Significant Obstruction in Uretero-pelvic Junction Syndrome Not yet recruiting NCT02812212
28 Comparison of Dynamic Contrast Enhanced CT and Diuretic Renogram in The Evaluation of UPJO Withdrawn NCT00199472

Search NIH Clinical Center for Ureteral Obstruction

Genetic Tests for Ureteral Obstruction

Anatomical Context for Ureteral Obstruction

MalaCards organs/tissues related to Ureteral Obstruction:

38
Kidney, Endothelial, Bone, Cervix, Bone Marrow, Monocytes, Prostate

Publications for Ureteral Obstruction

Articles related to Ureteral Obstruction:

(show top 50) (show all 713)
# Title Authors Year
1
As in Real Estate, Location Is What Matters: A Case Report of Transplant Ureteral Obstruction Due to an Inguinal Hernia. ( 29372065 )
2018
2
Is hydrogen sulfide a potential novel therapy to prevent renal damage during ureteral obstruction? ( 29269061 )
2018
3
Adenovirus-mediated P311 ameliorates renal fibrosis through inhibition of epithelial-mesenchymal transition via TGF-I^1-Smad-ILK pathway in unilateral ureteral obstruction rats. ( 29436600 )
2018
4
Validation of a model of feline ureteral obstruction as a tool for teaching microsurgery to veterinary surgeons. ( 29380880 )
2018
5
Encrusted Cystitis with Suspected Ureteral Obstruction Following Cystoscopic-Guided Laser Ablation of Ectopic Ureters in a Dog. ( 29372865 )
2018
6
Ablation of C/EBP homologous protein attenuates renal fibrosis after ureteral obstruction by reducing autophagy and microtubule disruption. ( 29425932 )
2018
7
Ultrasonography in the diagnosis and management of cats with ureteral obstruction. ( 29172872 )
2018
8
Ureteral obstruction and ruptured kidney following ovarian hyperstimulation syndrome. ( 29391290 )
2018
9
First Experience of Inserting a Metallic Mesh Stent (Uventa Stent) in Malignant Ureteral Obstruction in Iran. ( 29427286 )
2018
10
Does a Ureteral Obstruction Affect the Contralateral Kidney Morphology? A Stereological Analysis in a Rodent Model. ( 29421794 )
2018
11
Evaluation of renal metabolic response to partial ureteral obstruction with hyperpolarized<sup>13</sup>C MRI. ( 29130537 )
2018
12
Renal parenchyma impairment characterization in partial unilateral ureteral obstruction in mice with intravoxel incoherent motion-MRI. ( 29178439 )
2018
13
Demethylzeylasteral ameliorates inflammation in a rat model of unilateral ureteral obstruction through inhibiting activation of the NFa89I_B pathway. ( 28534978 )
2017
14
Sphingosine Kinase-2 Deficiency Ameliorates Kidney Fibrosis by Up-Regulating Smad7 in a Mouse Model of Unilateral Ureteral Obstruction. ( 28807595 )
2017
15
Longitudinal assessment of rabbit renal fibrosis induced by unilateral ureteral obstruction using two-dimensional susceptibility weighted imaging. ( 29236342 )
2017
16
Reactive oxygen species modulator 1 regulates oxidative stress and induces renal and pulmonary fibrosis in a unilateral ureteral obstruction rat model and in HKa892 cells. ( 28791399 )
2017
17
Fungal Bezoar: A Rare Cause of Ureteral Obstruction. ( 28804662 )
2017
18
Postrenal acute kidney injury in a patient with unilateral ureteral obstruction caused by urolithiasis: A case report. ( 29069033 )
2017
19
Lee AS, Lee JE, Jung YJ, etA al. Vascular endothelial growth factor-C and -D are involved in lymphangiogenesis in mouse unilateral ureteral obstruction. Kidney Int. 2013;83:50-62. ( 28938942 )
2017
20
Renal recruitment of B lymphocytes exacerbates tubulointerstitial fibrosis by promoting monocyte mobilization and infiltration after unilateral ureteral obstruction. ( 27763657 )
2017
21
Outcomes of indwelling metallic stents for malignant extrinsic ureteral obstruction. ( 29194771 )
2017
22
Ethanol extract of gardenia fruit alleviates renal interstitial fibrosis induced by unilateral ureteral obstruction in rats. ( 28810600 )
2017
23
Ureteral Obstruction Due to Radiolucent Atazanavir Ureteral Stones. ( 29098200 )
2017
24
The bladder ran dry: bilateral ureteral obstruction. ( 28784872 )
2017
25
TRAP1 ameliorates renal tubulointerstitial fibrosis in mice with unilateral ureteral obstruction by protecting renal tubular epithelial cell mitochondria. ( 28710113 )
2017
26
Intermedin attenuates renal fibrosis by induction of heme oxygenase-1 in rats with unilateral ureteral obstruction. ( 28697727 )
2017
27
Kidney Injury due to Ureteral Obstruction Caused by Compression from Infected Simple Hepatic Cyst. ( 28626377 )
2017
28
Invasive Candida Infection with Ureteral Obstruction. ( 29279474 )
2017
29
Notch signaling in the collecting duct regulates renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction in mice. ( 28602064 )
2017
30
Inguinal Bladder Hernia With Acute Ureteral Obstruction 14 Years After Kidney Transplantation: A Case Report. ( 28838448 )
2017
31
Inhibition of Necroptosis Attenuates Kidney Inflammation and Interstitial Fibrosis Induced By Unilateral Ureteral Obstruction. ( 28723681 )
2017
32
Vascular endothelial growth factor-C ameliorates renal interstitial fibrosis through lymphangiogenesis in mouse unilateral ureteral obstruction. ( 29083411 )
2017
33
MicroRNA-148b regulates megalin expression and is associated with receptor downregulation in mice with unilateral ureteral obstruction. ( 28331063 )
2017
34
Nrf2 deficiency promotes the progression from acute tubular damage to chronic renal fibrosis following unilateral ureteral obstruction. ( 29126308 )
2017
35
Deficiency of mPGES-1 exacerbates renal fibrosis and inflammation in mice with unilateral ureteral obstruction. ( 27784694 )
2017
36
Macrophages Regulate Unilateral Ureteral Obstruction-Induced Renal Lymphangiogenesis through C-C Motif Chemokine Receptor 2-Dependent Phosphatidylinositol 3-Kinase-AKT-Mechanistic Target ofA Rapamycin Signaling and Hypoxia-Inducible Factor-1I+/Vascular Endothelial Growth Factor-C Expression. ( 28627412 )
2017
37
Mast Cells and MCPT4 Chymase Promote Renal Impairment after Partial Ureteral Obstruction. ( 28523000 )
2017
38
Retrograde pyelography predicts retrograde ureteral stenting failure and reduces unnecessary stenting trials in patients with advanced non-urological malignant ureteral obstruction. ( 28931043 )
2017
39
Thymoquinone ameliorates renal damage in unilateral ureteral obstruction in rats. ( 28521173 )
2017
40
Fluoride potentiates tubulointerstitial nephropathy caused by unilateral ureteral obstruction. ( 29024711 )
2017
41
Human Umbilical Cord-Derived Mesenchymal Stem Cells Conditioned Medium Attenuate Interstitial Fibrosis and Stimulate the Repair of Tubular Epithelial Cells in an Irreversible Model of Unilateral Ureteral Obstruction. ( 28667820 )
2017
42
Intermedin inhibits unilateral ureteral obstruction-induced oxidative stress via NADPH oxidase Nox4 and cAMP-dependent mechanisms. ( 28805491 )
2017
43
The effect of aliskiren on the renal dysfunction following unilateral ureteral obstruction in the rat. ( 27570581 )
2016
44
Delayed-onset Ureteral Obstruction and Calcification Masquerading as Renal Colic Following Deflux Injection. ( 26970448 )
2016
45
T-type calcium channel blocker attenuates unilateral ureteral obstruction-induced renal interstitial fibrosis by activating the Nrf2 antioxidant pathway. ( 27904663 )
2016
46
Metabolomics study of renal fibrosis and intervention effects of total aglycone extracts of Scutellaria baicalensis in unilateral ureteral obstruction rats. ( 27286917 )
2016
47
Improving Comfort of Patients with Ureteral Obstruction and Malignant Disease Should Be of Concern. ( 27387032 )
2016
48
Melatonin protects kidney against apoptosis induced by acute unilateral ureteral obstruction in rats. ( 27551563 )
2016
49
CD11ca8_ CD8a8_ T Cells Reduce Renal Fibrosis Following Ureteric Obstruction by Inducing Fibroblast Apoptosis. ( 28025478 )
2016
50
Downregulation of angiotensin type 1 receptor and nuclear factor-I_B by sirtuin 1 contributes to renoprotection in unilateral ureteral obstruction. ( 27659793 )
2016

Variations for Ureteral Obstruction

Expression for Ureteral Obstruction

Search GEO for disease gene expression data for Ureteral Obstruction.

Pathways for Ureteral Obstruction

Pathways related to Ureteral Obstruction according to GeneCards Suite gene sharing:

(show all 33)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.74 BMP6 BMP7 CTNNB1 IL10 NOS2 PTGS2
2
Show member pathways
13.54 BMP6 BMP7 EPO IL10 NOS2 PTGS2
3
Show member pathways
13.39 AGTR1 AGTR2 BMP6 BMP7 EPO HSPB1
4
Show member pathways
13.35 BMP6 BMP7 HSPB1 IL10 TGFB1 TP53
5
Show member pathways
13.21 BMP6 BMP7 CTNNB1 IL10 NOX4 TGFB1
6
Show member pathways
12.93 BMP6 BMP7 CTNNB1 NOS2 PTGS2 VEGFC
7
Show member pathways
12.93 AGTR1 AGTR2 BMP6 BMP7 PTGS2 TGFB1
8
Show member pathways
12.45 AGTR1 CTNNB1 IL10 NOS2 TP53
9
Show member pathways
12.4 BMP7 CTNNB1 NOX4 TGFB1
10
Show member pathways
12.31 CTNNB1 HSPB1 NOS2 PTGS2
11
Show member pathways
12.15 IL10 NOS2 PTGS2 TGFB1
12 12.13 BMP6 BMP7 CTNNB1 TGFB1
13 12.05 CTNNB1 NOS2 PTGS2 TGFB1 TP53
14 12.02 BMP6 BMP7 CTNNB1 TGFB1
15 11.95 AGTR1 CTNNB1 EPO NOS2 PTGS2 TGFB1
16 11.85 NOS2 NOX4 PTGS2 TGFB1 TP53
17 11.81 BMP6 BMP7 TGFB1
18 11.79 NOS2 PTGS2 TP53
19 11.79 AGTR1 NOX4 TGFB1 VEGFC
20
Show member pathways
11.78 CTNNB1 HSPB1 VEGFC
21 11.78 IL10 NOS2 PTGS2 TGFB1 TP53
22 11.76 HSPB1 IL10 NOS2 TGFB1
23 11.75 PTGS2 TGFB1 VEGFC
24 11.73 BMP6 BMP7 TGFB1
25
Show member pathways
11.69 AGTR1 AGTR2 TGFB1
26 11.6 IL10 NOS2 TGFB1
27 11.58 BMP6 BMP7 TGFB1
28 11.52 BMP6 BMP7 CTNNB1 HSPB1 TGFB1 TP53
29 11.47 EPO TP53 VEGFC
30 11.41 NOS2 PTGS2 TGFB1 TP53
31 11.13 EPO NOS2 PTGS2 TP53
32 11 HSPB1 NOS2 PTGS2 TP53
33 10.95 BMP6 BMP7 IL10 TGFB1 VEGFC

GO Terms for Ureteral Obstruction

Cellular components related to Ureteral Obstruction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 apical plasma membrane GO:0016324 9.02 AQP2 LRP2 NOX4 SLC12A1 SLC9A3

Biological processes related to Ureteral Obstruction according to GeneCards Suite gene sharing:

(show all 47)
# Name GO ID Score Top Affiliating Genes
1 regulation of receptor activity GO:0010469 9.97 BMP6 BMP7 EPO IL10 TGFB1 VEGFC
2 response to lipopolysaccharide GO:0032496 9.95 EPO IL10 NOS2 PTGS2
3 positive regulation of transcription, DNA-templated GO:0045893 9.95 AGTR2 BMP7 CTNNB1 EPO IL10 TGFB1
4 inflammatory response GO:0006954 9.91 AGTR2 BMP6 IL10 NOX4 PTGS2 TGFB1
5 regulation of cell proliferation GO:0042127 9.88 AGTR1 CTNNB1 NOS2 PTGS2 TGFB1
6 response to organic substance GO:0010033 9.87 IL10 PTGS2 TGFB1
7 BMP signaling pathway GO:0030509 9.87 BMP6 BMP7 TGFB1
8 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.86 TGFB1 TP53 VEGFC
9 positive regulation of neuron differentiation GO:0045666 9.85 BMP6 BMP7 EPO
10 cellular response to mechanical stimulus GO:0071260 9.85 BMP6 PTGS2 TGFB1
11 positive regulation of apoptotic process GO:0043065 9.85 BMP7 CTNNB1 NOX4 PTGS2 TGFB1 TP53
12 positive regulation of endothelial cell proliferation GO:0001938 9.83 BMP6 IL10 VEGFC
13 response to glucocorticoid GO:0051384 9.83 BMP6 IL10 PTGS2
14 positive regulation of epithelial cell proliferation GO:0050679 9.83 BMP6 TGFB1 VEGFC
15 kidney development GO:0001822 9.83 AGTR1 BMP6 BMP7 CTNNB1
16 SMAD protein signal transduction GO:0060395 9.82 BMP6 BMP7 TGFB1
17 positive regulation of osteoblast differentiation GO:0045669 9.81 BMP6 BMP7 CTNNB1
18 response to estradiol GO:0032355 9.81 BMP7 CTNNB1 PTGS2 TGFB1
19 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 9.8 BMP6 BMP7 TGFB1
20 positive regulation of epithelial to mesenchymal transition GO:0010718 9.79 BMP7 CTNNB1 TGFB1
21 negative regulation of cell cycle GO:0045786 9.78 BMP7 PTGS2 TGFB1
22 positive regulation of protein secretion GO:0050714 9.77 BMP6 TGFB1 VEGFC
23 epithelial to mesenchymal transition GO:0001837 9.76 BMP7 CTNNB1 TGFB1
24 response to organonitrogen compound GO:0010243 9.75 AGTR2 PTGS2 TP53
25 positive regulation of blood vessel endothelial cell migration GO:0043536 9.74 HSPB1 TGFB1 VEGFC
26 positive regulation of bone mineralization GO:0030501 9.73 BMP6 BMP7 TGFB1
27 response to drug GO:0042493 9.73 CTNNB1 IL10 PTGS2 TGFB1 TP53 VEGFC
28 response to hypoxia GO:0001666 9.72 EPO NOS2 NOX4 TGFB1 VEGFC
29 positive regulation of reactive oxygen species metabolic process GO:2000379 9.71 AGTR1 NOX4 TP53
30 regulation of blood vessel diameter GO:0097746 9.7 AGTR1 AGTR2
31 positive regulation of endothelial cell differentiation GO:0045603 9.7 BMP6 CTNNB1
32 positive regulation of SMAD protein import into nucleus GO:0060391 9.69 BMP6 TGFB1
33 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.68 BMP7 IL10
34 morphogenesis of embryonic epithelium GO:0016331 9.68 CTNNB1 VEGFC
35 positive regulation of histone deacetylation GO:0031065 9.67 TGFB1 TP53
36 salivary gland morphogenesis GO:0007435 9.67 BMP7 TGFB1
37 angiotensin-activated signaling pathway GO:0038166 9.66 AGTR1 AGTR2
38 regulation of protein import into nucleus GO:0042306 9.64 AGTR2 TGFB1
39 response to vitamin D GO:0033280 9.63 BMP7 PTGS2 TGFB1
40 regulation of apoptotic process GO:0042981 9.63 AGTR2 BMP6 BMP7 CTNNB1 TGFB1 TP53
41 negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress GO:1902219 9.62 EPO PTGS2
42 renin-angiotensin regulation of aldosterone production GO:0002018 9.59 AGTR1 AGTR2
43 aging GO:0007568 9.43 EPO IL10 NOX4 PTGS2 TGFB1 TP53
44 negative regulation of cell proliferation GO:0008285 9.23 BMP7 CTNNB1 IL10 NOX4 PTGS2 TGFB1
45 negative regulation of apoptotic process GO:0043066 10.09 EPO HSPB1 IL10 PTGS2 TP53
46 cell proliferation GO:0008283 10.03 CTNNB1 EPO LRP2 TGFB1 TP53
47 positive regulation of cell proliferation GO:0008284 10.02 AGTR2 CTNNB1 EPO PTGS2 TGFB1 VEGFC

Molecular functions related to Ureteral Obstruction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein heterodimerization activity GO:0046982 9.8 AGTR1 BMP6 CTNNB1 TGFB1 TP53
2 transforming growth factor beta receptor binding GO:0005160 9.43 BMP6 BMP7 TGFB1
3 BMP receptor binding GO:0070700 9.37 BMP6 BMP7
4 cytokine activity GO:0005125 9.35 BMP6 BMP7 EPO IL10 TGFB1
5 angiotensin type II receptor activity GO:0004945 9.16 AGTR1 AGTR2
6 growth factor activity GO:0008083 9.02 BMP6 BMP7 IL10 TGFB1 VEGFC
7 protein binding GO:0005515 10.25 AGTR1 AGTR2 AQP2 BMP7 CTNNB1 EPO

Sources for Ureteral Obstruction

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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