MCID: URT014
MIFTS: 35

Ureterolithiasis

Categories: Nephrological diseases

Aliases & Classifications for Ureterolithiasis

MalaCards integrated aliases for Ureterolithiasis:

Name: Ureterolithiasis 12 42 14 69
Calculus of Ureter 12
Ureteric Calculus 12
Ureteral Calculi 69
Ureteric Stone 12

Classifications:



External Ids:

Disease Ontology 12 DOID:14146
ICD9CM 35 592.1
MeSH 42 D053039
NCIt 47 C114696
SNOMED-CT 64 31054009 95573009
ICD10 33 N20.1
UMLS 69 C0041952

Summaries for Ureterolithiasis

MalaCards based summary : Ureterolithiasis, also known as calculus of ureter, is related to nephrolithiasis and brain glioblastoma multiforme. An important gene associated with Ureterolithiasis is APRT (Adenine Phosphoribosyltransferase), and among its related pathways/superpathways are Salivary secretion and Monoamine GPCRs. The drugs Tamsulosin and Alfuzosin have been mentioned in the context of this disorder. Affiliated tissues include kidney and adrenal gland, and related phenotypes are behavior/neurological and homeostasis/metabolism

Wikipedia : 72 Kidney stone disease, also known as urolithiasis, is when a solid piece of material (kidney stone)... more...

Related Diseases for Ureterolithiasis

Graphical network of the top 20 diseases related to Ureterolithiasis:



Diseases related to Ureterolithiasis

Symptoms & Phenotypes for Ureterolithiasis

MGI Mouse Phenotypes related to Ureterolithiasis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.55 ADRA1A AKAP5 APRT CHRM3 TRPV1
2 homeostasis/metabolism MP:0005376 9.43 ADRA1A AKAP5 APRT CHRM3 SLC12A3 TRPV1
3 renal/urinary system MP:0005367 9.02 ADRA1A APRT CHRM3 SLC12A3 TRPV1

Drugs & Therapeutics for Ureterolithiasis

Drugs for Ureterolithiasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 67)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tamsulosin Approved, Investigational Phase 4,Phase 3,Phase 2,Early Phase 1 106133-20-4 129211
2
Alfuzosin Approved, Investigational Phase 4,Phase 3,Phase 2,Early Phase 1 81403-80-7 2092
3
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
4
Morphine Approved, Investigational Phase 4 57-27-2 5288826
5
Ketoprofen Approved, Vet_approved Phase 4 22071-15-4 3825
6
Silodosin Approved Phase 4,Phase 3,Phase 2 160970-54-7
7
Acetaminophen Approved Phase 4,Phase 3 103-90-2 1983
8
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
9
Tadalafil Approved, Investigational Phase 4 171596-29-5 110635
10 Naftopidil Investigational Phase 4,Phase 3 57149-07-2
11 Nefopam Investigational Phase 4 13669-70-0
12 Adrenergic Agents Phase 4,Phase 3,Phase 2,Early Phase 1
13 Adrenergic alpha-1 Receptor Antagonists Phase 4,Phase 3,Phase 2,Early Phase 1
14 Adrenergic alpha-Antagonists Phase 4,Phase 3,Phase 2,Early Phase 1
15 Adrenergic Antagonists Phase 4,Phase 3,Phase 2,Early Phase 1
16 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Early Phase 1
17 Antihypertensive Agents Phase 4,Phase 3
18 calcium channel blockers Phase 4,Phase 3
19 Calcium, Dietary Phase 4,Phase 3
20 Platelet Aggregation Inhibitors Phase 4,Phase 3
21 Analgesics Phase 4,Phase 3
22 Analgesics, Non-Narcotic Phase 4
23 Analgesics, Opioid Phase 4
24 Anti-Inflammatory Agents Phase 4
25 Anti-Inflammatory Agents, Non-Steroidal Phase 4
26 Antirheumatic Agents Phase 4
27 Central Nervous System Depressants Phase 4
28 Cyclooxygenase Inhibitors Phase 4
29 Ketorolac Tromethamine Phase 4
30 Narcotics Phase 4
31 Peripheral Nervous System Agents Phase 4,Phase 3
32 Vasodilator Agents Phase 4,Phase 3
33 Antipyretics Phase 4
34 Pharmaceutical Solutions Phase 4
35 Phosphodiesterase 5 Inhibitors Phase 4
36 Phosphodiesterase Inhibitors Phase 4
37 Sildenafil Citrate Phase 4 171599-83-0
38 Citrate Nutraceutical Phase 4
39
Citric Acid Nutraceutical, Vet_approved Phase 4 77-92-9 311
40
Doxazosin Approved Phase 3 74191-85-8 3157
41
Nifedipine Approved Phase 3 21829-25-4 4485
42
Prazosin Approved Phase 3 19216-56-9 4893
43
Aceclofenac Approved Phase 3 89796-99-6
44
Tramadol Approved, Investigational Phase 3 27203-92-5 33741
45 Tocolytic Agents Phase 3
46 Mirabegron Approved Phase 2 223673-61-8
47 Adrenergic Agonists Phase 2
48 Adrenergic beta-3 Receptor Agonists Phase 2
49 Adrenergic beta-Agonists Phase 2
50
Lidocaine Approved, Vet_approved 137-58-6 3676

Interventional clinical trials:

(show top 50) (show all 66)

id Name Status NCT ID Phase Drugs
1 The Use of Medical-Expulsive Therapy With Alfuzocine xl 10mg x1/d for Distal Ureterolithiasis.a Randomized Prospective Study Unknown status NCT00489112 Phase 4 Alfuzocine XL 10 mg once a day
2 Efficacy of Tamsulosin Oral-controlled Absorption System (OCAS) in the Treatment of Distal Ureteral Stones Unknown status NCT01167062 Phase 4 Tamsulosin Hydrochloride OCAS 0.4 mg
3 The Efficacy of Alpha-blockers for Expulsion of Distal Ureteral Stones Unknown status NCT00451061 Phase 4 Alfuzosin;Tamsulosin
4 Naftopidil 75mg for Improving Clearance of Urinary Stones Unknown status NCT02011737 Phase 4 naftopidil 75mg
5 Efficacy of Nefopam and Morphine in Balanced Analgesia for Acute Ureteric Colic Unknown status NCT01543165 Phase 4 Ketorolac and nefopam balanced analgesia;Balanced analgesia using ketorolac and morphine;Pain control with single analgesics (ketorolac)
6 Nefopam and Morphine Consumption in the Treatment of Ureteral Calculi Completed NCT00639574 Phase 4 Néfopam
7 Efficacy and Safety of Silodosin in the Treatment of Natural Expulsion in Patients With Ureteral Stones Completed NCT01533389 Phase 4 Silodosin;Placebo
8 Tamsulosin for Urolithiasis in the Emergency Dept Completed NCT00382265 Phase 4 tamsulosin
9 Efficacy Study of Different Analgesic Options in Kidney Stone Pain Management Completed NCT02187614 Phase 4 Diclofenac;Morphine;Paracetamol;Placebos
10 Treatment of Upper Ureteric Stones Recruiting NCT02469766 Phase 4
11 Phosphodiesterase 5 Inhibitors (PDE5i) (Sildenafil) as Medical Expulsive Therapy in Distal Ureteral Stones Active, not recruiting NCT02519153 Phase 4 Sildenafil
12 Trial of Tadalafil, Tamsulosin and Combination for Access Sheath Deployment Enrolling by invitation NCT03229889 Phase 4 Cialis 5Mg Tablet;Flomax 0.4Mg Capsule;Placebo
13 Silodosin Versus Tamsulosin for Treatment of Ureteral Stones Terminated NCT02369744 Phase 4 Silodosin;Tamsulosin
14 Celecoxib (Celebrex) in the Management of Acute Renal Colic Withdrawn NCT00304317 Phase 4 celecoxib
15 Alfuzosin for Medical Expulsion Therapy of Ureteral Stones Unknown status NCT00713739 Phase 3 Alfuzosin;nifedipine;doxazosin;prazosin
16 Evaluation of Tamsulosin in the Treatment of Ureteral Stones Completed NCT00151567 Phase 3 Tamsulosin;Placebo
17 Medical Expulsive Therapy for Ureter Stone Using Naftopidil Completed NCT01952314 Phase 3 Naftopidil 75mg;Placebo for Naftopidil;Standard treatment
18 Alfuzosin Hydrochloride to Promote Passage of Distal Ureteral Calculi Completed NCT00177086 Phase 3
19 Effectiveness of Silodosin in Medical Expulsive Therapy for Ureteral Pelvic Stone From 4 to 10 mm. Terminated NCT02090439 Phase 3 Silodosin
20 Use of Alfuzosin in Stone Treatment With ESWL Withdrawn NCT00388271 Phase 3 Alfuzosin (Xatral);standard treatment
21 Comparing Patients After ESWL Treated With Ureteral Stents Versus Expulsion Therapy With Tamsulosin Unknown status NCT00478998 Phase 2 Tamsulosin
22 Does Treatment With Alfuzosin Increase Success Rates of (SWL) Shock Wave Lithotripsy Unknown status NCT00409227 Phase 2 Alpha blocker-alfuzosin;placebo
23 Study of Silodosin to Facilitate Passage of Urinary Stones Completed NCT01144949 Phase 2 silodosin;placebo
24 A Dose-finding Study of Silodosin in Patients With Urinary Calculi Completed NCT01539265 Phase 2 silodosin;silodosin;placebo
25 Mirabegron as Medical Expulsive Therapy (MET) for Ureteral Stones and Ureteral Stent Pain Not yet recruiting NCT02744430 Phase 2 Mirabegron
26 Feasibility Study of the Uriprene Stent Following Uncomplicated Ureteroscopy Completed NCT02032316 Phase 1
27 Silent Ureteral Stone: Impact on Renal Function and Kidney Anatomy Unknown status NCT01884870
28 Comparative Treatment Study in Patients With Lower Ureteral Stones Unknown status NCT00397397 Early Phase 1
29 Shockwave Lithotripsy (SWL) Under Selective, General Anesthesia. Unknown status NCT01008267
30 Prospective Comparison Between Different Laser Settings for Ureteral \ Kidney Stones Treatment During Ureteroscopy Unknown status NCT02279927
31 Intraureteral Lidocaine for Post-Ureteroscopy Pain Unknown status NCT01450566 Lidocaine;Saline
32 Delayed or Direct Ureteroscopy in the Treatment of Pediatric Calcular Anuria Unknown status NCT02139059
33 The Efficacy of Tamsulosin in the Treatment of Ureteral Stones in Emergency Department Patients Completed NCT00600405 tamsulosin;Standard therapy with ibuprofen and oxycodone.
34 Study on 'The Use of Non-contrast Helical Computerized Tomogram in Predicting Treatment Outcomes of Upper Ureteric Stone by Extracorporeal Shock Wave Lithotripsy Using the Sonolith 4000+ Lithotripter' Completed NCT00517205
35 Medical Expulsive Therapy of Single Distal Ureteral Stones Completed NCT00831701 Tamsulosin;Placebo
36 The Efficacy of Tamsulosin in the Treatment of Ureteral Stones in Emergency Department Patients Completed NCT00448123 Tamsulosin;Placebo
37 Management of Ureteral Calculi Using Ultrasound Guidance: A Radiation Free Approach Completed NCT01792765
38 Effect of Tamsulosin on Stone Expulsion and Pain Resolution in ED Patients With Ureterolithiasis Completed NCT00762424 Flowmax;placebo
39 Is Prophylactic Antibiotics Necessary In Otherwise Healthy Adult Patients Undergoing Ureteroscopic Procedures for Ureteral Stones? Completed NCT02635490 Early Phase 1
40 Use of the PercSys MicroStent Device to Alleviate Ureteral Stone Symptoms and Hydronephrosis Completed NCT01637519
41 Ureteral Stents Versus Percutaneous Nephrostomy for Initial Urinary Drainage Completed NCT02055430
42 Role of Flexible Cystoscopy in Laparoscopic Stone Surgery Completed NCT01277198
43 The Usefulness of Flexible Cystoscopy for Preventing Double-J Stent Malposition After Laparoscopic Ureterolithotomy Completed NCT03150446
44 Management of Fragments During Ureteroscopy Completed NCT00637650
45 Evaluating Ureteral Length Using Computed Tomography (CT) Completed NCT01542593
46 Analysis the Relationship Between the Abdomen CT and Outcomes in Acute Urinary Stone Patients Completed NCT02983409
47 Escalating, Constant and Reduction Energy Output in SWL for Renal Stones Completed NCT02037906
48 Trial Comparing Relapse Rates Between Standard Ureteroscopic Removal Of Ureteral Stone And Standard Removal With Additional Ureterorenic Clearing Of Non-Symptomatic Stones In The Kidney Recruiting NCT02210650
49 ESWL for Distal Ureteric Stone: Supine Versus Prone Recruiting NCT02298465
50 US-Non Contrast Computed Tomography Real-time Fusion for Urinary Stones Follow up Recruiting NCT02539004

Search NIH Clinical Center for Ureterolithiasis

Cochrane evidence based reviews: ureterolithiasis

Genetic Tests for Ureterolithiasis

Anatomical Context for Ureterolithiasis

MalaCards organs/tissues related to Ureterolithiasis:

39
Kidney, Adrenal Gland

Publications for Ureterolithiasis

Articles related to Ureterolithiasis:

(show top 50) (show all 90)
id Title Authors Year
1
Spontaneous proximal ureteric rupture secondary to ureterolithiasis. ( 28069871 )
2017
2
Ureterolithiasis: Management in an environment with limited facilities. ( 28513524 )
2017
3
Comparison between double-pigtail ureteral stents and ureteral bypass devices for treatment of ureterolithiasis in cats. ( 28763282 )
2017
4
Clinical relevance of seasonal changes in the prevalence of ureterolithiasis in the diagnosis of renal colic. ( 27314408 )
2016
5
Management of Ureterolithiasis in a Patient with Crossed Unfused Renal Ectopia. ( 27403369 )
2016
6
Is hydronephrosis on ultrasound predictive of ureterolithiasis in patients with renal colic? ( 27154825 )
2016
7
Beyond ureterolithiasis: gamut of abnormalities affecting the ureter. ( 27317212 )
2016
8
Medical Expulsive Therapy for Ureterolithiasis: The EAU Recommendations in 2016. ( 27506951 )
2016
9
Comparison of prone vs. supineA unenhanced CT imaging in patients with clinically suspected ureterolithiasis. ( 27670877 )
2016
10
The use of alpha-1 adrenergic blockers in children with distal ureterolithiasis: a systematic review and meta-analysis. ( 26717117 )
2015
11
Long-term Adverse Effects of Extracorporeal Shock-wave Lithotripsy for Nephrolithiasis and Ureterolithiasis: A Systematic Review. ( 25917723 )
2015
12
Tamsulosin for treatment of unilateral distal ureterolithiasis: a systematic review and meta-analysis. ( 24852587 )
2014
13
Indwelling double pigtail ureteral stent combined or not with surgery for feline ureterolithiasis: complications and outcome in 15 cases. ( 24305471 )
2013
14
Terpene compound drug as medical expulsive therapy for ureterolithiasis: a meta-analysis. ( 23503876 )
2013
15
Anuria and abdominal pain induced by ceftriaxone-associated ureterolithiasis in adults. ( 23180444 )
2013
16
Tamsulosin for treatment of unilateral distal ureterolithiasis: a systematic review and meta-analysis. ( 23870675 )
2013
17
Re: terpene compound drug as medical expulsive therapy for ureterolithiasis: a meta-analysis. ( 23421365 )
2013
18
Pyeloduodenal fistula due to proximal ureterolithiasis and its successful conservative management. ( 24051966 )
2013
19
Bedside renal ultrasound in the evaluation of suspected ureterolithiasis. ( 21185667 )
2012
20
Endoscopic holmium laser treatment for ureterolithiasis. ( 24578918 )
2012
21
Synchronous obstructive ureterolithiasis and acute appendicitis. ( 24960802 )
2012
22
Unusual presentation of bilateral ureteroceles with ureterolithiasis in a patient after robotic prostatectomy. ( 22546412 )
2012
23
Bladder bulge: unifying old and new sonographic bladder wall abnormalities in ureterolithiasis. ( 23358632 )
2012
24
Ureterolithiasis in children. ( 21585171 )
2011
25
Health related quality of life in ureteral stone patients: post-ureterolithiasis. ( 21461963 )
2011
26
The effect of alpha-blockade in emergency department patients with ureterolithiasis. ( 19217243 )
2010
27
The sensitivity of transabdominal ultrasound in the diagnosis of ureterolithiasis. ( 21203595 )
2010
28
A case of calcified ureteritis cystica: an indiscernible condition from ureterolithiasis. ( 19655701 )
2009
29
Acute onset of renal colic from bilateral ureterolithiasis: a case report. ( 19829794 )
2009
30
Usefulness of urinalysis in following patients with distal ureterolithiasis. ( 18578655 )
2008
31
Cost-effectiveness analysis (CEA) of intravenous urography (IVU) and unenhanced multidetector computed tomography (MDCT) for initial investigation of suspected acute ureterolithiasis. ( 18300151 )
2008
32
Conventional and reduced radiation dose of 16-MDCT for detection of nephrolithiasis and ureterolithiasis. ( 18094305 )
2008
33
The utility of unenhanced helical CT in assessing the frequency of ureterolithiasis in Saudi patients. ( 18246228 )
2008
34
Type IV ureteral triplication associated with ipsilateral ureterocele with ureterolithiasis and contralateral duplication with an ectopic ureteral orifice. ( 19138195 )
2008
35
Comparison between ultrasound and noncontrast helical computed tomography for identification of acute ureterolithiasis in a teaching hospital setting. ( 17625708 )
2007
36
Ureteroscopical treatment of ureterolithiasis in childhood. Our experience. ( 16752883 )
2006
37
Electro-acupuncture treatment for the upper segment ureterolithiasis under B-ultrasonography. ( 15889513 )
2005
38
Medical-expulsive therapy for distal ureterolithiasis: randomized prospective study on role of corticosteroids used in combination with tamsulosin-simplified treatment regimen and health-related quality of life. ( 16230122 )
2005
39
Diagnostic value of attenuation measurements of the kidney on unenhanced helical CT of obstructive ureterolithiasis. ( 15100127 )
2004
40
Unenhanced helical CT of ureterolithiasis: incidence of secondary urinary tract findings. ( 15058632 )
2004
41
Ureterolithiasis after Cohen re-implantation--case report. ( 15070415 )
2004
42
Unenhanced helical CT scan for ureterolithiasis. ( 15321049 )
2004
43
Helical CT for nephrolithiasis and ureterolithiasis: comparison of conventional and reduced radiation-dose techniques. ( 14526095 )
2003
44
Pneumatic lithotripsy for ureterolithiasis: clinical analysis of 512 cases. ( 12865242 )
2003
45
Acute ureterolithiasis: incidence of secondary signs on unenhanced helical CT and influence on patient management. ( 14654033 )
2003
46
Acute flank pain: comparison of unenhanced helical CT and ultrasonography in detecting causes other than ureterolithiasis. ( 15290574 )
2002
47
Speedy elimination of ureterolithiasis in lower part of ureters with the alpha 1-blocker--Tamsulosin. ( 12549635 )
2002
48
Ureterolithiasis: classical and atypical findings on unenhanced helical computed tomography. ( 15290602 )
2002
49
Management of calcium ureterolithiasis in a French lop rabbit. ( 11791774 )
2001
50
The role of renal scintigraphy and unenhanced helical computerized tomography in patients with ureterolithiasis. ( 10805118 )
2000

Variations for Ureterolithiasis

Expression for Ureterolithiasis

Search GEO for disease gene expression data for Ureterolithiasis.

Pathways for Ureterolithiasis

Pathways related to Ureterolithiasis according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
11.17 ADRA1A CHRM3
2
Show member pathways
10.68 ADRA1A CHRM3

GO Terms for Ureterolithiasis

Cellular components related to Ureterolithiasis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 8.92 ADRA1A CHRM3 SLC12A3 TRPV1

Biological processes related to Ureterolithiasis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 positive regulation of cytosolic calcium ion concentration GO:0007204 9.26 ADRA1A TRPV1
2 regulation of vasoconstriction GO:0019229 9.16 ADRA1A CHRM3
3 positive regulation of smooth muscle contraction GO:0045987 8.96 ADRA1A CHRM3
4 smooth muscle contraction GO:0006939 8.62 ADRA1A CHRM3

Sources for Ureterolithiasis

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7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
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48 NDF-RT
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55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
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67 TGDB
68 Tocris
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70 UMLS via Orphanet
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