MCID: URT035
MIFTS: 27

Urethral Benign Neoplasm

Categories: Cancer diseases, Rare diseases

Aliases & Classifications for Urethral Benign Neoplasm

MalaCards integrated aliases for Urethral Benign Neoplasm:

Name: Urethral Benign Neoplasm 12
Urethral Neoplasms 41 69
Urethra Cancer 12 14
Malignant Neoplasm of Urethra 69
Malignant Tumour of Urethra 12
Malignant Urethral Neoplasm 12
Neoplasm of Urethra 12
Urethral Carcinoma 69
Neoplasm. Urethra 12
Cancer of Urethra 12
Urethral Ca 12

Classifications:



External Ids:

Disease Ontology 12 DOID:730 DOID:734
MeSH 41 D014523
ICD10 32 C68.0
ICD9CM 34 189.3

Summaries for Urethral Benign Neoplasm

Disease Ontology : 12 An urinary tract cancer that derives from the tissues of the urethra.

MalaCards based summary : Urethral Benign Neoplasm, also known as urethral neoplasms, is related to urethra adenocarcinoma and posterior urethra cancer. An important gene associated with Urethral Benign Neoplasm is FNDC3B (Fibronectin Type III Domain Containing 3B), and among its related pathways/superpathways is Hematopoietic Stem Cell Gene Regulation by GABP alpha/beta Complex. The drugs Cisplatin and Carboplatin have been mentioned in the context of this disorder. Related phenotype is homeostasis/metabolism.

Related Diseases for Urethral Benign Neoplasm

Diseases in the Urethral Cancer family:

Urethral Benign Neoplasm

Diseases related to Urethral Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 45)
# Related Disease Score Top Affiliating Genes
1 urethra adenocarcinoma 27.8 ALK AMACR ANKRD28 APP ARID2 ATM
2 posterior urethra cancer 12.0
3 anterior urethra cancer 12.0
4 urethra transitional cell carcinoma 10.9
5 urethral cancer 10.9
6 urethra squamous cell carcinoma 10.9
7 small cell neuroendocrine carcinoma 10.3 CHGA KLK3
8 prostate signet ring cell adenocarcinoma 10.3 CEACAM5 KLK3
9 nodular ganglioneuroblastoma 10.2 ALK CHGA
10 prostate squamous cell carcinoma 10.2 CEACAM5 KLK3
11 prostatic acinar adenocarcinoma 10.2 AMACR KLK3
12 vulval paget's disease 10.2 CEACAM5 UPK3A
13 nephrogenic adenoma 10.2 AMACR KLK3
14 endodermal sinus tumor 10.2 CHGA KLK3
15 rete testis adenocarcinoma 10.2 CEACAM5 KLK3
16 vulva adenocarcinoma 10.2 CEACAM5 UPK3A
17 atypical follicular adenoma 10.2 CEACAM5 CHGA
18 acute thyroiditis 10.2 CEACAM5 CHGA
19 pancreatic serous cystadenoma 10.2 CEACAM5 CHGA
20 liver sarcoma 10.1 CEACAM5 CHGA
21 rete testis neoplasm 10.1 CEACAM5 KLK3
22 gastric small cell carcinoma 10.1 CEACAM5 CHGA
23 radiation cystitis 10.1 ATM KLK3 UPK3A
24 telangiectasis 10.1 ATM SMAD4
25 parotid gland cancer 10.1 ALK SMAD4
26 pancreatic cystadenocarcinoma 10.1 CEACAM5 CHGA
27 acinar cell carcinoma 10.1 CHGA SMAD4
28 urethral diverticulum 10.0 AMACR KLK3 UPK3A
29 clear cell adenocarcinoma 10.0 AMACR KLK3 SMAD4
30 female urethral cancer 10.0 CEACAM5 CHGA KLK3
31 suppression of tumorigenicity 12 10.0 AMACR CHGA KLK3
32 male reproductive organ cancer 10.0 AMACR CHGA KLK3
33 binswanger's disease 10.0 APP CHGA
34 mixed ductal-endocrine carcinoma 10.0 CEACAM5 CHGA SMAD4
35 descending colon cancer 9.9 APP CEACAM5
36 endocrine gland cancer 9.9 CEACAM5 CHGA SMAD4
37 bladder disease 9.9 KLK3 UPK3A
38 prostate disease 9.9 AMACR KLK3
39 gastric adenocarcinoma 9.9 CEACAM5 CHGA SMAD4
40 urethritis 9.7
41 prostatitis 9.7
42 prostatic adenoma 9.7
43 adenoma 9.7
44 cell type cancer 9.7 ALK CEACAM5 CHGA KLK3
45 urethra clear cell adenocarcinoma 7.7 ALK AMACR ANKRD28 APP ARID2 ATM

Comorbidity relations with Urethral Benign Neoplasm via Phenotypic Disease Network (PDN):


Acute Cystitis Bladder Cancer
Hydronephrosis Prostate Cancer
Prostatic Hypertrophy

Graphical network of the top 20 diseases related to Urethral Benign Neoplasm:



Diseases related to Urethral Benign Neoplasm

Symptoms & Phenotypes for Urethral Benign Neoplasm

MGI Mouse Phenotypes related to Urethral Benign Neoplasm:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.28 SMAD4 UPK3A ALK AMACR APP ARID2

Drugs & Therapeutics for Urethral Benign Neoplasm

Drugs for Urethral Benign Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 87)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved Phase 3,Phase 2,Phase 1 15663-27-1 2767 441203 84093
2
Carboplatin Approved Phase 3,Phase 2,Phase 1 41575-94-4 10339178 38904 498142
3
Gemcitabine Approved Phase 3,Phase 2,Phase 1 95058-81-4 60750
4
Doxorubicin Approved, Investigational Phase 3,Phase 2,Phase 1 23214-92-8 31703
5
Vinblastine Approved Phase 3,Phase 2,Phase 1 865-21-4 241903 13342
6
Paclitaxel Approved, Vet_approved Phase 3,Phase 2,Phase 1 33069-62-4 36314
7
Methotrexate Approved Phase 3,Phase 2 1959-05-2, 59-05-2 126941
8
Bevacizumab Approved, Investigational Phase 3 216974-75-3
9
leucovorin Approved, Nutraceutical Phase 3,Phase 2 58-05-9 143 6006
10
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3,Phase 2,Phase 1 59-30-3 6037
11
Doxil Approved June 1999 Phase 3,Phase 2,Phase 1 31703
12 Angiogenesis Inhibitors Phase 3,Phase 2,Phase 1
13 Angiogenesis Modulating Agents Phase 3,Phase 2,Phase 1
14 Anti-Infective Agents Phase 3,Phase 2,Phase 1
15 Immunosuppressive Agents Phase 3,Phase 2,Phase 1
16 Antimetabolites Phase 3,Phase 2,Phase 1
17 Antimetabolites, Antineoplastic Phase 3,Phase 2,Phase 1
18 Antiviral Agents Phase 3,Phase 2,Phase 1
19 Folic Acid Antagonists Phase 3,Phase 2
20 Albumin-Bound Paclitaxel Phase 3,Phase 2,Phase 1
21 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1
22 Nucleic Acid Synthesis Inhibitors Phase 3,Phase 2
23 Dermatologic Agents Phase 3,Phase 2
24 Vitamin B Complex Phase 3,Phase 2,Phase 1
25 Anti-Bacterial Agents Phase 3,Phase 1,Phase 2
26 Antimitotic Agents Phase 3,Phase 2,Phase 1
27 Antibiotics, Antitubercular Phase 3,Phase 1,Phase 2
28 Antineoplastic Agents, Phytogenic Phase 3,Phase 2,Phase 1
29 Antirheumatic Agents Phase 3,Phase 2
30 Antibodies, Monoclonal Phase 3,Phase 2,Phase 1
31 Immunoglobulins Phase 3,Phase 2,Phase 1
32 Antibodies Phase 3,Phase 2,Phase 1
33 Mitogens Phase 3
34 Endothelial Growth Factors Phase 3
35 Folate Nutraceutical Phase 3,Phase 2,Phase 1
36 Vitamin B9 Nutraceutical Phase 3,Phase 2,Phase 1
37
Sunitinib Approved, Investigational Phase 2 341031-54-7, 557795-19-4 5329102
38
Fluorouracil Approved Phase 2 51-21-8 3385
39
Irinotecan Approved, Investigational Phase 2 97682-44-5, 100286-90-6 60838
40
Gefitinib Approved, Investigational Phase 2 184475-35-2 123631
41
Ifosfamide Approved Phase 2 3778-73-2 3690
42
Bortezomib Approved, Investigational Phase 2,Phase 1 179324-69-7 387447 93860
43
Miconazole Approved, Investigational, Vet_approved Phase 1, Phase 2 22916-47-8 4189
44
Trastuzumab Approved, Investigational Phase 2,Phase 1 180288-69-1 9903
45
Mechlorethamine Approved, Investigational Phase 2 51-75-2 4033
46
Everolimus Approved Phase 1, Phase 2 159351-69-6 6442177
47
Lenograstim Approved, Investigational Phase 2 135968-09-1
48
Pemetrexed Approved, Investigational Phase 2 150399-23-8, 137281-23-3 60843 446556
49
Sirolimus Approved, Investigational Phase 1, Phase 2 53123-88-9 46835353 6436030 5284616
50
Arsenic trioxide Approved, Investigational Phase 2 1327-53-3 518740

Interventional clinical trials:

(show top 50) (show all 63)

# Name Status NCT ID Phase Drugs
1 Combination Chemotherapy in Treating Patients With Bladder Cancer Completed NCT00003701 Phase 3 carboplatin;cisplatin;doxorubicin hydrochloride;methotrexate;paclitaxel;vinblastine sulfate
2 Two-Drug Combination Chemotherapy Compared With Four-Drug Combination Chemotherapy in Treating Patients With Advanced Cancer of the Urothelium Completed NCT00003376 Phase 3 carboplatin;cisplatin;doxorubicin hydrochloride;methotrexate;paclitaxel;vinblastine
3 Cisplatin Plus Gemcitabine With or Without Paclitaxel in Treating Patients With Stage IV Urinary Tract Cancer Completed NCT00022191 Phase 3 cisplatin;gemcitabine hydrochloride;paclitaxel
4 Combination Chemotherapy in Treating Patients With Transitional Cell Cancer of the Urothelium Completed NCT00014274 Phase 2, Phase 3 carboplatin;gemcitabine hydrochloride;methotrexate;vinblastine sulfate
5 Four Cycles Versus Six Cycles of Cisplatin-based Chemotherapy in Metastatic Urothelial Carcinoma Recruiting NCT03296306 Phase 3 Treatment duration of cisplatin based chemotherapy
6 Gemcitabine Hydrochloride and Cisplatin With or Without Bevacizumab in Treating Patients With Advanced Urinary Tract Cancer Active, not recruiting NCT00942331 Phase 3 Cisplatin;Gemcitabine Hydrochloride
7 Carboplatin and Gemcitabine Hydrochloride With or Without Vandetanib as First-Line Therapy in Treating Patients With Locally Advanced or Metastatic Urinary Tract Cancer Unknown status NCT01191892 Phase 2 carboplatin;gemcitabine hydrochloride;vandetanib;Placebo
8 Sunitinib Malate in Treating Patients With Locally Recurrent, Locally Advanced, Unresectable, or Metastatic Urinary Tract Cancer Unknown status NCT01118039 Phase 2 sunitinib malate
9 Surgery Plus Combination Chemotherapy and Radiation Therapy in Treating Patients With Cancer of the Urinary Tract Unknown status NCT00006111 Phase 2 cisplatin;fluorouracil
10 Gemcitabine Hydrochloride, Cisplatin, and Sunitinib Malate as First-Line Therapy in Treating Patients With Locally Advanced And/or Metastatic Transitional Cell Carcinoma of the Urothelium Unknown status NCT01089088 Phase 2 cisplatin;gemcitabine hydrochloride;sunitinib malate
11 TOCOSOL(TM) Paclitaxel in Metastatic or Locally Advanced Unresectable Transitional Cell Carcinoma of the Urothelium Completed NCT00077688 Phase 2 TOCOSOL Paclitaxel
12 S0121, Neoadjuvant Carboplatin, Paclitaxel, and Gemcitabine Followed by Cisplatin and Radiation Therapy in Treating Patients With Locally Advanced or Recurrent Carcinoma of the Urothelium Completed NCT00055835 Phase 2 carboplatin;cisplatin;gemcitabine hydrochloride;paclitaxel
13 Combination Chemotherapy in Patients With Advanced Urinary Tract Cancer Completed NCT00002684 Phase 2 cisplatin;ifosfamide;paclitaxel
14 Pazopanib Hydrochloride in Treating Patients With Metastatic Urethral Cancer or Bladder Cancer That Has Relapsed or Not Responded to Treatment Completed NCT01031875 Phase 2 pazopanib hydrochloride
15 Gemcitabine Hydrochloride, Cisplatin, and Temsirolimus as First-Line Therapy in Treating Patients With Locally Advanced and/or Metastatic Transitional Cell Cancer of the Urothelium Completed NCT01090466 Phase 1, Phase 2 cisplatin;gemcitabine hydrochloride;temsirolimus
16 Piritrexim in Treating Patients With Advanced Cancer of the Urinary Tract Completed NCT00002914 Phase 2 piritrexim
17 Neoadjuvant Ifosfamide, Doxorubicin, Gemcitabine, and Cisplatin in Treating Patients Who Are Undergoing Radical Cystectomy for Locally Advanced Carcinoma (Cancer) of the Urothelium Completed NCT00080795 Phase 2 cisplatin;doxorubicin hydrochloride;gemcitabine hydrochloride;ifosfamide
18 Nitrocamptothecin in Treating Patients With Metastatic Cancer of the Urinary Tract Completed NCT00006026 Phase 2 rubitecan
19 Docetaxel and Gemcitabine in Treating Patients With Progressive Regional or Metastatic Bladder Cancer Completed NCT00004223 Phase 2 docetaxel;gemcitabine hydrochloride
20 Arsenic Trioxide in Treating Patients With Urothelial Cancer Completed NCT00009867 Phase 2 arsenic trioxide
21 Pemetrexed Disodium and Gemcitabine in Treating Patients With Advanced Cancer of the Urothelium Completed NCT00053209 Phase 2 gemcitabine hydrochloride;pemetrexed disodium
22 S0219, Combination Chemotherapy Followed By Observation or Surgery in Patients With Stage II or Stage III Cancer of the Urothelium Completed NCT00045630 Phase 2 carboplatin;gemcitabine;paclitaxel
23 SCH 66336 Plus Gemcitabine in Treating Patients With Advanced Cancer of the Urinary Tract Completed NCT00006351 Phase 2 gemcitabine hydrochloride;lonafarnib
24 Combination Chemotherapy in Treating Patients With Advanced Cancer of the Urothelium and Decreased Kidney Function Completed NCT00005644 Phase 2 gemcitabine hydrochloride;paclitaxel
25 Pazopanib in Treating Patients With Metastatic Urothelial Cancer Completed NCT00471536 Phase 2 pazopanib hydrochloride
26 Sunitinib in Treating Patients With Progressive Metastatic Transitional Cell Cancer of the Urothelium Completed NCT00397488 Phase 2 sunitinib malate
27 Fluorouracil in Treating Patients With Recurrent or Metastatic Bladder Cancer Completed NCT00003175 Phase 2 fluorouracil
28 S0031, ZD 1839 in Treating Patients With Advanced Cancer of the Urinary Tract Completed NCT00014144 Phase 2 gefitinib
29 S0306, Irinotecan in Treating Patients With Recurrent or Refractory Advanced Transitional Cell Cancer of the Urothelium Previously Treated With Chemotherapy Completed NCT00066612 Phase 2 irinotecan hydrochloride
30 A Phase II Study of AZD4877 (a Novel Anti-mitotic Agent) in Advanced Bladder Cancer Completed NCT00661609 Phase 2 AZD4877
31 Gemcitabine, Paclitaxel, Doxorubicin in Metastatic or Unresectable Bladder Cancer With Decreased Kidney Function Completed NCT00478361 Phase 2 Gemcitabine hydrochloride;Paclitaxel;Doxorubicin hydrochloride;Pegfilgrastim
32 Phase II Trial Of PS-341 (Bortezomib) In Patients With Previously Treated Advanced Urothelial Tract Transitional Cell Carcinoma Completed NCT00072150 Phase 2 bortezomib
33 Ixabepilone in Treating Patients With Advanced Urinary Tract Cancer Completed NCT00021099 Phase 2 ixabepilone
34 VEGF Trap in Treating Patients With Recurrent, Locally Advanced, or Metastatic Cancer of the Urothelium Completed NCT00407485 Phase 2
35 LCI-GU-URO-CRI-001: Crizotinib in Patients With c-MET or RON-Positive Metastatic Urothelial Cancer Recruiting NCT02612194 Phase 2 Crizotinib
36 A Study of Enfortumab Vedotin for Patients With Locally Advanced or Metastatic Urothelial Bladder Cancer Recruiting NCT03219333 Phase 2 Enfortumab vedotin
37 Afatinib in Advanced Refractory Urothelial Cancer Recruiting NCT02122172 Phase 2 afatinib dimaleate
38 Atezolizumab With or Without Eribulin Mesylate in Treating Patients With Recurrent Locally Advanced or Metastatic Urothelial Cancer Recruiting NCT03237780 Phase 2 Atezolizumab;Eribulin Mesylate
39 Cabozantinib for Advanced Urothelial Cancer Active, not recruiting NCT01688999 Phase 2 Cabozantinib
40 Gemcitabine Hydrochloride and Eribulin Mesylate in Treating Patients With Bladder Cancer That is Advanced or Cannot Be Removed by Surgery Active, not recruiting NCT02178241 Phase 2 Eribulin Mesylate;Gemcitabine Hydrochloride
41 Fluorouracil, Leucovorin, Gemcitabine, and Cisplatin in Treating Patients With Metastatic or Unresectable Adenocarcinoma of the Urothelium or Urachal Remnant Active, not recruiting NCT00082706 Phase 2 5-Fluorouracil (5-FU);Leucovorin;Cisplatin;Gemcitabine
42 A Study of ALT-801 in Combination With Cisplatin and Gemcitabine in Muscle Invasive or Metastatic Urothelial Cancer Active, not recruiting NCT01326871 Phase 1, Phase 2 Cisplatin;Gemcitabine
43 A Trial With Vinflunine in Patients With Metastatic Bladder Cancer and Impaired Renal Function Active, not recruiting NCT02665039 Phase 2 Vinflunine;Gemcitabine;Carboplatin
44 Gemcitabine Hydrochloride and Cisplatin Before Surgery in Treating Patients With Muscle Invasive Bladder Cancer Terminated NCT01611662 Phase 2 gemcitabine hydrochloride;cisplatin
45 S0028, Gemcitabine and Paclitaxel in Treating Patients With Advanced or Recurrent Cancer of the Urinary Tract Terminated NCT00022633 Phase 2 gemcitabine hydrochloride;paclitaxel
46 S0400, FR901228 in Treating Patients With Advanced Cancer of the Urothelium Terminated NCT00087295 Phase 2 Depsipeptide
47 Trastuzumab in Treating Patients With Previously Treated, Locally Advanced, or Metastatic Cancer of the Urothelium Terminated NCT00004856 Phase 2
48 Sorafenib in Treating Patients With Regional or Metastatic Cancer of the Urothelium Terminated NCT00112905 Phase 2 sorafenib tosylate
49 Gemcitabine Hydrochloride and Cisplatin or High-Dose Methotrexate, Vinblastine, Doxorubicin Hydrochloride, and Cisplatin in Treating Patients With Urothelial Cancer Withdrawn NCT01639521 Phase 2 cisplatin;gemcitabine hydrochloride;methotrexate;vinblastine;doxorubicin hydrochloride
50 Short-Term Low-Dose Interferon Alfa in Treating Patients With Cancer of the Urothelium Completed NCT00082719 Phase 1

Search NIH Clinical Center for Urethral Benign Neoplasm

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: urethral neoplasms

Genetic Tests for Urethral Benign Neoplasm

Anatomical Context for Urethral Benign Neoplasm

Publications for Urethral Benign Neoplasm

Articles related to Urethral Benign Neoplasm:

# Title Authors Year
1
Case profile: prostatic adenoma masquerading as primary urethral neoplasm. ( 2459832 )
1988

Variations for Urethral Benign Neoplasm

Expression for Urethral Benign Neoplasm

Search GEO for disease gene expression data for Urethral Benign Neoplasm.

Pathways for Urethral Benign Neoplasm

Pathways related to Urethral Benign Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 9.97 ATM SMAD4

GO Terms for Urethral Benign Neoplasm

Biological processes related to Urethral Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ovarian follicle development GO:0001541 9.16 ATM SMAD4
2 neuron apoptotic process GO:0051402 8.96 APP ATM
3 female gonad development GO:0008585 8.62 ATM SMAD4

Sources for Urethral Benign Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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