Urethral Calculus disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MalaCards based summary: Urethral Calculus, also known as calculus in urethra, is related to urethritis and prostatitis. An important gene associated with Urethral Calculus is PLIN1 (Perilipin 1), and among its related pathways are Platelet Aggregation Inhibitor Pathway, Pharmacodynamics and Androgen receptor signaling pathway. Affiliated tissues include prostate, pancreas and kidney.

Related Diseases for Urethral Calculus

Sources:
²⁰GeneAnalytics, ²¹GeneCards, ⁶⁸UMLS
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Diseases related to Urethral Calculus via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 24)

id	Related Disease	Score	Top Affiliating Genes
1	urethritis	10.6
2	prostatitis	10.1
3	myiasis	10.0	F2, FLNA
4	boomerang dysplasia	10.0	FLNA, ITGA2
5	cervical polyp	10.0	FLNA, ITGA2
6	fibular collateral ligament bursitis	10.0	F2, FLNA
7	gingival hypertrophy	9.9	FLNA, KLK3
8	nephrolithiasis	9.7
9	hypospadias	9.7
10	ureterocele	9.7
11	choreatic disease	9.7	ITGA2, KLK3
12	sacrococcygeal teratoma	9.7	F2, ITGA2
13	pyridoxamine 5'-phosphate oxidase deficiency	9.7	F2, ITGA2
14	carotid artery dissection	9.7	KLK3, MCU
15	senile entropion	9.7	F2, KLK3
16	malignant granular cell skin tumor	9.7	F2, KLK3
17	guillain-barre syndrome	9.7	F2, KLK3
18	balanitis xerotica obliterans	9.7
19	scrotum melanoma	9.6	KLK3, MCU
20	thrombocytopenia with elevated serum iga and renal disease	9.6	F2, ITGA2
21	brain glioblastoma multiforme	9.6	KLK3, MCU
22	fasciitis	9.6	F2, FLNA, ITGA2
23	bernard-soulier syndrome, type c	9.5	F2, ITGA2
24	lower urinary tract calculus	8.9	F2, FLNA, ITGA2, KLK3

Comorbidity relations with Urethral Calculus via Phenotypic Disease Network (PDN):

Prostate Cancer	Nephrolithiasis
Hydronephrosis	Prostatic Hypertrophy
Acute Cystitis	Bladder Neck Obstruction
Ureterolithiasis	Urethral Stricture

Graphical network of the top 20 diseases related to Urethral Calculus:

Symptoms & Phenotypes for Urethral Calculus

Drugs & Therapeutics for Urethral Calculus

Sources:
¹BitterDB, ⁴ClinicalTrials, ¹⁰DGIdb, ¹⁴DrugBank, ²⁹HMDB, ³³IUPHAR, ⁵⁰Novoseek, ⁵⁶PharmGKB
See all MalaCards sources

Drugs for Urethral Calculus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

id	Name	Status	Phase	Clinical Trials	Cas Number	PubChem Id
1	Central Nervous System Depressants			12806
2	Anesthetics			9001

Interventional clinical trials:

id	Name	Status	NCT ID	Phase
1	Shock Wave Lithotripsy Versus Visual Cystolitholapaxy in The Management of Patients Presenting With Calcular Acute Urinary Retention: A Randomized Controlled Trial.	Recruiting	NCT02594631	Phase 4
2	Effects of Thoracic Epidural Anesthesia on Lower Urinary Tract Function	Completed	NCT00790231
3	Natural Orifice Translumenal Endoscopic Surgery (NOTES) Transvaginal Cholecystectomy	Completed	NCT00984100
4	"Dusting" Versus "Basketing" - Treatment Of Intrarenal Stones	Active, not recruiting	NCT01619735
5	Conditional Imaging Prescription Strategy for Exploration of Acute Uncomplicated Renal Colic	Not yet recruiting	NCT02878148
6	The Effect of Transvaginal vs. Conventional Laparoscopic Cholecystectomy on the Postoperative Course	Terminated	NCT01552421

Search NIH Clinical Center for Urethral Calculus

Genetic Tests for Urethral Calculus

Anatomical Context for Urethral Calculus

Sources:
³⁶MalaCards
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MalaCards organs/tissues related to Urethral Calculus:

³⁶

Prostate, Pancreas, Kidney

Publications for Urethral Calculus

Sources:
⁵⁷PubMed
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Articles related to Urethral Calculus:

(show top 50) (show all 57)

id	Title	Authors	Year
1	Giant anterior urethral calculus associated with urethrocutaneous fistula in an elderly man. (27671903)	Wei T.... Wang K.	2016
2	Urethral calculus originating from ureterocele and causing urinary retention. (26498566)	Penkoff P.... Bariol S.	2015
3	A Giant Urethral Calculus. (26982670)	Sigdel G.... Keshaw B.W.	2014
4	A giant dumbbell shaped vesico-prostatic urethral calculus: a case report and review of literature. (23762742)	Prabhuswamy V.K.... Krishnamoorthy R.	2013
5	Large anterior urethral calculus presented as scrotal mass with urethrocutaneous fistula. (24068377)	Prakash J.... Goel A.	2013
6	Impacted anterior urethral calculus complicated by a stone-containing diverticulum in an elderly man: outcome of transurethral lithotripsy without resection of the diverticulum. (24267119)	Zhou T.... Sun Y.	2013
7	Urethral calculus. (19939603)	Halberg M.... Sweeney T.W.	2012
8	Obstructing urethral calculus in a woman revealed to be the cause of chronic pelvic pain. (22407234)	Thomas J.S.... Crew J.	2012
9	Giant urethral calculus. (24950400)	Kotkar K.... Songra M.	2011
10	Unusual giant prostatic urethral calculus. (22091328)	Bello A.... Ahmed A.	2010
11	Acute urinary retention secondary to a urethral calculus in a bladder-drained kidney pancreas transplant patient - a metallic clip nidus. (19215698)	Smith J.B.... Olsburgh J.	2009
12	Impacted urethral calculus discovered on pelvic ultrasound: a case report. (19947057)	Soe K.... Moskowitz H.	2009
13	Giant urethral calculus in a 6-year-old girl. (19013415)	Rivilla F.... Ruiz A.	2008
14	Transrectal voiding sonourethrography for diagnosis of a prostatic urethral calculus. (17060434)	Mihmanli I.... Kadioglu A.	2006
15	Giant prostatic urethral calculus associated with urethrocutaneous fistula. (16771746)	Kaplan M.... Inci O.	2006
16	Laser lithotripsy of a urethral calculus via ischial urethrotomy in a steer. (11549094)	Streeter R.N.... Bartels K.E.	2001
17	Urethral calculus extraction using a penile ring block anesthetic. (9800901)	Jezior J.R.... Schwartz B.F.	1998
18	Giant urethral calculus: a rare cause of acute urinary retention. (8969990)	Larkin G.L.... Weber J.E.	1996
19	Giant urethral calculus. (7899907)	Win T.	1994
20	Pediatric bladder outlet obstruction due to urethral calculus. Case report and review of the literature. (8309762)	Seltzer L.G.... Miller S.Z.	1993
21	Formation of a urethral calculus around an unusual foreign body. (8402033)	Noble J.G.... Chapple C.R.	1993
22	Use of transperineal sonography to locate an obstructing urethral calculus. (8416631)	Lewellyn S.... Abbitt P.L.	1993
23	Struvite urethral calculus in a three-month-old thoroughbred colt. (1643877)	Vacek J.R.... Everett K.A.	1992
24	Giant posterior urethral calculus. (2337755)	Bolukbasi A.... Gumus B.	1990
25	Re: Giant posterior urethral calculus. A. Bolukbasi and B. Gumus. Br. J. Urol., 65, 301-302, 1990. (2249137)	HADDAD F.S.	1990
26	Giant urethral calculus. (2611634)	BaA+os J.L.... RodrA-guez R.H.	1989
27	Expulsion of urethral calculus following intermittent closure of suprapubic catheter. (2804575)	Mhiri M.N.... Smida M.L.	1989
28	Sonographic diagnosis of an obstructing urethral calculus. (3054147)	Bundy A.L.... Gluck C.L.	1988
29	Spontaneous passage of large urethral calculus. (3942026)	Cummings J.M.... Gregory J.G.	1986
30	Ultrasonic detection of urethral calculus. (3904910)	Gammelgaard J.... Hastak S.M.	1985
31	Giant urethral calculus in a nine-year-old girl. (3971095)	Ahmed S.	1985
32	Giant anterior urethral calculus associated with hypospadias and congenital meatal stenosis. (3971094)	Al-Saleh B.M.... Adam S.	1985
33	Foreign body urethral calculus 9 years after traumatic perforation of the rectum. (4005511)	Ahmed S.... Morris L.	1985
34	Impacted membranous urethral calculus. (6520412)	Maatman T.J.... Resnick M.I.	1984
35	Spontaneous delivery of giant urethral calculus. (6674358)	Khamesra H.L.... Agarwal R.K.	1983
36	Submucosal urethral calculus secondary to foxtail awn migration in a dog. (6345496)	Morshead D.	1983
37	Giant prostatic urethral calculus. (A case report). (6864581)	Deodhar S.D.... Khope S.	1983
38	Case profile: radiolucent urethral calculus with hemostatic clip nidus. (7064268)	Miedema E.B.... Redman J.F.	1982
39	Giant urethral calculus: a case report. (561198)	de Carvalho H.A.	1977
40	Giant urethral calculus: a case report. (940221)	Hassan R.M.	1976
41	Prostatic urethral calculus. (5016075)	Ireland G.W.... Cass A.S.	1972
42	Urethral calculus in a six-week-old puppy. (6070657)	Fowler N.G.	1967
43	Impacted urethral calculus. An analysis of 42 cases. (5945414)	Sachdev Y.V.	1966
44	Surgical management of an unusual urethral calculus. (13980456)	TEIMOURIAN B.... CULBERTSON L.R.	1963
45	Impacted vesico-urethral calculus: a case report. (13900169)	GONZALES A.C.... MALATE B.A.	1961
46	Giant urethral calculus: a case report. (13564579)	VANDERHORST L.F.	1958
47	Urethral calculus: its roentgen evaluation. (13134511)	FRIEDMAN P.S.... JOFFE S.M.	1954
48	Urethral calculus in the male, with particular reference to giant primary stones. (15399440)	LOWSLEY O.S.... Gentile A.	1950
49	Large urethral calculus; case report. (18141445)	Reynolds L.R.... HAMMER H.J.	1949
50	Giant urethral calculus. (18921040)	HIGGINS C.C.... HAUSFELD K.F.	1948

Genes related to Urethral Calculus

Sources:
¹³DISEASES, ²¹GeneCards
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Genes related to Urethral Calculus:

- Elite gene

- Cancer Census gene in COSMIC

id	Symbol	Description	Score	Implication
1	PLIN1	Perilipin 1	15.46	DISEASES inferred ¹³
2	USF1	Upstream Transcription Factor 1	15.30	DISEASES inferred ¹³
3	FLNA	Filamin A	14.86	DISEASES inferred ¹³
4	ITGA2	Integrin Subunit Alpha 2	14.64	DISEASES inferred ¹³
5	F2	Coagulation Factor II, Thrombin	13.55	DISEASES inferred ¹³
6	KLK3	Kallikrein Related Peptidase 3	13.30	DISEASES inferred ¹³
7	MCU	Mitochondrial Calcium Uniporter	6.05	DISEASES inferred ¹³

Variations for Urethral Calculus

Expression for genes affiliated with Urethral Calculus

Sources:
¹⁸Gene Expression Omnibus DataSets
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Search GEO for disease gene expression data for Urethral Calculus.

Pathways for genes affiliated with Urethral Calculus

Sources:
⁴²NCBI BioSystems Database, ⁵⁵PathCards, ⁵⁶PharmGKB, ⁶⁰Reactome
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Pathways related to Urethral Calculus according to GeneCards Suite gene sharing:

id	Super pathways	Score	Top Affiliating Genes
1	Platelet Aggregation Inhibitor Pathway, Pharmacodynamics⁵⁶	9.3	F2, ITGA2
2	Androgen receptor signaling pathway⁴²	9.2	FLNA, KLK3
3	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)⁶⁰	9.0	F2, KLK3

GO Terms for genes affiliated with Urethral Calculus

Sources:
¹⁹Gene Ontology
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Biological processes related to Urethral Calculus according to GeneCards Suite gene sharing:

id	Name	GO ID	Score	Top Affiliating Genes
1	glucose homeostasis	GO:0042593	10.1	MCU, USF1
2	establishment of protein localization	GO:0045184	10.1	FLNA, ITGA2
3	negative regulation of fibrinolysis	GO:0051918	10.0	F2, USF1
4	cellular response to mechanical stimulus	GO:0071260	9.9	F2, ITGA2
5	platelet activation	GO:0030168	9.8	F2, FLNA
6	positive regulation of collagen biosynthetic process	GO:0032967	9.3	F2, ITGA2