MCID: URT011
MIFTS: 30

Urethral Calculus

Categories: Nephrological diseases

Aliases & Classifications for Urethral Calculus

MalaCards integrated aliases for Urethral Calculus:

Name: Urethral Calculus 12 14
Calculus in Urethra 69
Urethral Stone 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9589
ICD10 32 N21.1
ICD9CM 34 594.2
NCIt 46 C26995
SNOMED-CT 64 155880008 20342001
UMLS 69 C0162301

Summaries for Urethral Calculus

MalaCards based summary : Urethral Calculus, also known as calculus in urethra, is related to urethritis and prostatitis. An important gene associated with Urethral Calculus is PLIN1 (Perilipin 1), and among its related pathways/superpathways are Ca, cAMP and Lipid Signaling and Androgen receptor signaling pathway. Affiliated tissues include kidney, prostate and pancreas, and related phenotype is behavior/neurological.

Wikipedia : 72 Kidney stone disease, also known as urolithiasis, is when a solid piece of material (kidney stone)... more...

Related Diseases for Urethral Calculus

Diseases related to Urethral Calculus via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 15)
# Related Disease Score Top Affiliating Genes
1 urethritis 10.7
2 prostatitis 10.2
3 ureterocele 9.8
4 aging 9.8
5 episodic pain syndrome, familial, 1 9.8
6 nephrolithiasis 9.8
7 hypospadias 9.8
8 leech infestation 9.8 F2 FLNA
9 taylor's syndrome 9.8 F2 FLNA
10 paraphimosis 9.7 FLNA KLK3
11 suprasellar meningioma 9.6 F2 KLK3
12 urethral diverticulum 9.6 KLK3 MCU
13 acute cystitis 9.5 KLK3 MCU
14 bladder disease 9.4 KLK3 MCU
15 lower urinary tract calculus 8.9 F2 FLNA MCU PLIN1 USF1

Comorbidity relations with Urethral Calculus via Phenotypic Disease Network (PDN):


Acute Cystitis Bladder Neck Obstruction
Hydronephrosis Nephrolithiasis, X-Linked Recessive, with Renal Failure
Prostate Cancer Prostatic Hypertrophy
Ureterolithiasis Urethral Stricture

Graphical network of the top 20 diseases related to Urethral Calculus:



Diseases related to Urethral Calculus

Symptoms & Phenotypes for Urethral Calculus

MGI Mouse Phenotypes related to Urethral Calculus:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.02 F2 FLNA MCU PLIN1 USF1

Drugs & Therapeutics for Urethral Calculus

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Shock Wave Lithotripsy Versus Visual Cystolitholapaxy in The Management of Patients Presenting With Calcular Acute Urinary Retention: A Randomized Controlled Trial. Unknown status NCT02594631 Phase 4
2 Conditional Imaging Prescription Strategy for Exploration of Acute Uncomplicated Renal Colic Not yet recruiting NCT02878148

Search NIH Clinical Center for Urethral Calculus

Genetic Tests for Urethral Calculus

Anatomical Context for Urethral Calculus

MalaCards organs/tissues related to Urethral Calculus:

38
Kidney, Prostate, Pancreas

Publications for Urethral Calculus

Articles related to Urethral Calculus:

(show top 50) (show all 57)
# Title Authors Year
1
Giant anterior urethral calculus associated with urethrocutaneous fistula in an elderly man. ( 27671903 )
2016
2
Urethral calculus originating from ureterocele and causing urinary retention. ( 26498566 )
2015
3
A Giant Urethral Calculus. ( 26982670 )
2014
4
Impacted anterior urethral calculus complicated by a stone-containing diverticulum in an elderly man: outcome of transurethral lithotripsy without resection of the diverticulum. ( 24267119 )
2013
5
Large anterior urethral calculus presented as scrotal mass with urethrocutaneous fistula. ( 24068377 )
2013
6
A giant dumbbell shaped vesico-prostatic urethral calculus: a case report and review of literature. ( 23762742 )
2013
7
Obstructing urethral calculus in a woman revealed to be the cause of chronic pelvic pain. ( 22407234 )
2012
8
Urethral calculus. ( 19939603 )
2012
9
Giant urethral calculus. ( 24950400 )
2011
10
Unusual giant prostatic urethral calculus. ( 22091328 )
2010
11
Acute urinary retention secondary to a urethral calculus in a bladder-drained kidney pancreas transplant patient - a metallic clip nidus. ( 19215698 )
2009
12
Impacted urethral calculus discovered on pelvic ultrasound: a case report. ( 19947057 )
2009
13
Giant urethral calculus in a 6-year-old girl. ( 19013415 )
2008
14
Transrectal voiding sonourethrography for diagnosis of a prostatic urethral calculus. ( 17060434 )
2006
15
Giant prostatic urethral calculus associated with urethrocutaneous fistula. ( 16771746 )
2006
16
Laser lithotripsy of a urethral calculus via ischial urethrotomy in a steer. ( 11549094 )
2001
17
Urethral calculus extraction using a penile ring block anesthetic. ( 9800901 )
1998
18
Giant urethral calculus: a rare cause of acute urinary retention. ( 8969990 )
1996
19
Giant urethral calculus. ( 7899907 )
1994
20
Use of transperineal sonography to locate an obstructing urethral calculus. ( 8416631 )
1993
21
Pediatric bladder outlet obstruction due to urethral calculus. Case report and review of the literature. ( 8309762 )
1993
22
Formation of a urethral calculus around an unusual foreign body. ( 8402033 )
1993
23
Struvite urethral calculus in a three-month-old thoroughbred colt. ( 1643877 )
1992
24
Giant posterior urethral calculus. ( 2337755 )
1990
25
Re: Giant posterior urethral calculus. A. Bolukbasi and B. Gumus. Br. J. Urol., 65, 301-302, 1990. ( 2249137 )
1990
26
Giant urethral calculus. ( 2611634 )
1989
27
Expulsion of urethral calculus following intermittent closure of suprapubic catheter. ( 2804575 )
1989
28
Sonographic diagnosis of an obstructing urethral calculus. ( 3054147 )
1988
29
Spontaneous passage of large urethral calculus. ( 3942026 )
1986
30
Foreign body urethral calculus 9 years after traumatic perforation of the rectum. ( 4005511 )
1985
31
Ultrasonic detection of urethral calculus. ( 3904910 )
1985
32
Giant urethral calculus in a nine-year-old girl. ( 3971095 )
1985
33
Giant anterior urethral calculus associated with hypospadias and congenital meatal stenosis. ( 3971094 )
1985
34
Impacted membranous urethral calculus. ( 6520412 )
1984
35
Giant prostatic urethral calculus. (A case report). ( 6864581 )
1983
36
Submucosal urethral calculus secondary to foxtail awn migration in a dog. ( 6345496 )
1983
37
Spontaneous delivery of giant urethral calculus. ( 6674358 )
1983
38
Case profile: radiolucent urethral calculus with hemostatic clip nidus. ( 7064268 )
1982
39
Giant urethral calculus: a case report. ( 561198 )
1977
40
Giant urethral calculus: a case report. ( 940221 )
1976
41
Prostatic urethral calculus. ( 5016075 )
1972
42
Urethral calculus in a six-week-old puppy. ( 6070657 )
1967
43
Impacted urethral calculus. An analysis of 42 cases. ( 5945414 )
1966
44
Surgical management of an unusual urethral calculus. ( 13980456 )
1963
45
Impacted vesico-urethral calculus: a case report. ( 13900169 )
1961
46
Giant urethral calculus: a case report. ( 13564579 )
1958
47
Urethral calculus: its roentgen evaluation. ( 13134511 )
1954
48
Urethral calculus in the male, with particular reference to giant primary stones. ( 15399440 )
1950
49
Large urethral calculus; case report. ( 18141445 )
1949
50
Giant urethral calculus. ( 18921040 )
1948

Variations for Urethral Calculus

Expression for Urethral Calculus

Search GEO for disease gene expression data for Urethral Calculus.

Pathways for Urethral Calculus

Pathways related to Urethral Calculus according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.26 MCU PLIN1
2 10.91 FLNA KLK3
3 9.95 F2 KLK3

GO Terms for Urethral Calculus

Biological processes related to Urethral Calculus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 platelet activation GO:0030168 9.16 F2 FLNA
2 glucose homeostasis GO:0042593 8.96 MCU USF1
3 negative regulation of fibrinolysis GO:0051918 8.62 F2 USF1

Molecular functions related to Urethral Calculus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type peptidase activity GO:0008236 8.62 F2 KLK3

Sources for Urethral Calculus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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