MCID: URT037
MIFTS: 33

Urethral Stricture malady

Categories: Nephrological diseases

Aliases & Classifications for Urethral Stricture

Aliases & Descriptions for Urethral Stricture:

Name: Urethral Stricture 12 52 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:1829
ICD9CM 35 598.8
ICD10 33 N35
UMLS 69 C0029752

Summaries for Urethral Stricture

MalaCards based summary : Urethral Stricture is related to infective urethral stricture and urethral syndrome. An important gene associated with Urethral Stricture is KLK3 (Kallikrein Related Peptidase 3), and among its related pathways/superpathways is Adhesion. The drugs Ropivacaine and Dexmedetomidine have been mentioned in the context of this disorder. Affiliated tissues include prostate, skin and kidney.

Wikipedia : 71 A urethral stricture is a narrowing of the urethra caused by injury, instrumentation, infection and... more...

Related Diseases for Urethral Stricture

Diseases related to Urethral Stricture via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 42)
id Related Disease Score Top Affiliating Genes
1 infective urethral stricture 12.0
2 urethral syndrome 11.4
3 urethritis 11.1
4 pigmentary disorder, reticulate, with systemic manifestations 11.1
5 prostatitis 10.5
6 mucositis 10.4
7 hypospadias 10.3
8 lichen sclerosus 10.2
9 calcinosis 10.1 CTGF KLK3
10 vaginitis 10.1
11 balanitis 10.0
12 balanitis xerotica obliterans 10.0
13 prostate cancer 10.0
14 uterine corpus epithelioid leiomyoma 10.0 KLK3 SIRPA
15 hairy tongue 10.0 KLK3 MVD
16 posterior urethral valves 10.0
17 acute necrotizing encephalitis 10.0 CTGF KLK3
18 cystitis 9.9
19 squamous cell carcinoma 9.8
20 impotence 9.8
21 neuropathy 9.8
22 eosinophilic cystitis 9.8
23 brain injury 9.7
24 hemangioma 9.7
25 spinal cord injury 9.7
26 melanoma 9.7
27 urachal diverticulum 9.7
28 malignant hypertension 9.7
29 epidermolysis bullosa 9.7
30 junctional epidermolysis bullosa 9.7
31 transsexualism 9.7
32 ischemia 9.7
33 ureterocele 9.7
34 primary syphilis 9.7
35 syphilis 9.7
36 urinary tract obstruction 9.7
37 neuronitis 9.7
38 schistosomiasis 9.7
39 priapism 9.7
40 lymphangioma 9.7
41 urethral diverticulum 9.7
42 mononeuritis of upper limb 8.8 CLMP CTGF FAT4 KLHL24 KLK3 MVD

Comorbidity relations with Urethral Stricture via Phenotypic Disease Network (PDN): (show all 27)


Acute Cystitis Acute Kidney Failure
Balanoposthitis Bladder Neck Obstruction
Chronic Kidney Failure Chronic Myocardial Ischemia
Cystitis Cystitis Cystica
Deficiency Anemia Epididymo-Orchitis
Hydronephrosis Ischemic Heart Disease
Nephrolithiasis, Type I Neurogenic Bladder
Peyronie's Disease Prostate Calculus
Prostate Cancer Prostatic Hypertrophy
Prostatitis Radiation Cystitis
Trigonitis Ureterolithiasis
Urethral Calculus Urethral Gland Abscess
Urethritis Urinary Bladder Cancer
Urinary Tract Obstruction

Graphical network of the top 20 diseases related to Urethral Stricture:



Diseases related to Urethral Stricture

Symptoms & Phenotypes for Urethral Stricture

Drugs & Therapeutics for Urethral Stricture

Drugs for Urethral Stricture (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 70)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
2
Dexmedetomidine Approved, Vet_approved Phase 4 76631-46-4, 113775-47-6 68602 5311068 56032
3 Adrenergic Agents Phase 4
4 Adrenergic Agonists Phase 4
5 Adrenergic alpha-Agonists Phase 4
6 Anesthetics Phase 4,Phase 1,Phase 2
7 Neurotransmitter Agents Phase 4
8 Peripheral Nervous System Agents Phase 4,Phase 2
9 Central Nervous System Depressants Phase 4,Phase 2
10 Anesthetics, Local Phase 4,Phase 2
11 Adrenergic alpha-2 Receptor Agonists Phase 4
12 Analgesics Phase 4
13 Analgesics, Non-Narcotic Phase 4
14 Hypnotics and Sedatives Phase 4
15
Tacrolimus Approved, Investigational Phase 2, Phase 3 104987-11-3 445643 439492
16 Pharmaceutical Solutions Phase 3
17 Antibodies Phase 2, Phase 3
18 Antibodies, Monoclonal Phase 2, Phase 3
19 Calcineurin Inhibitors Phase 2, Phase 3
20 Immunoglobulins Phase 2, Phase 3
21 Immunosuppressive Agents Phase 2, Phase 3
22
Lidocaine Approved, Vet_approved Phase 2 137-58-6 3676
23 Alkylating Agents Phase 1, Phase 2
24 Anti-Bacterial Agents Phase 1, Phase 2
25 Antibiotics, Antitubercular Phase 1, Phase 2
26 Mitomycins Phase 1, Phase 2
27 Nucleic Acid Synthesis Inhibitors Phase 1, Phase 2
28 Anti-Arrhythmia Agents Phase 2
29 Diuretics, Potassium Sparing Phase 2
30 Sodium Channel Blockers Phase 2
31 Fibrin Tissue Adhesive Phase 1
32
Epinephrine Approved, Vet_approved 51-43-4 5816
33
Menthol Approved 2216-51-5 16666
34
Triamcinolone Approved, Vet_approved 124-94-7 31307
35
Methylprednisolone Approved, Vet_approved 83-43-2 6741
36
Prednisolone Approved, Vet_approved 50-24-8 5755
37
Vitamin A Approved, Nutraceutical, Vet_approved 11103-57-4, 68-26-8 445354
38 Adrenergic beta-Agonists
39 Anti-Asthmatic Agents
40 Autonomic Agents
41 Bronchodilator Agents
42 Coagulants
43 Epinephryl borate
44 Hemostatics
45 Mydriatics
46 Racepinephrine
47 Respiratory System Agents
48 Vasoconstrictor Agents
49 Parasympatholytics
50 Anti-Inflammatory Agents

Interventional clinical trials:

(show all 28)
id Name Status NCT ID Phase
1 Efficiency of Cold vs. Laser Internal Urethrotomy Treatment of Urethral Strictures Unknown status NCT01196572 Phase 4
2 PVP Compared to TURP for the Treatment of Benign Hyperplasia of the Prostate Completed NCT00527371 Phase 4
3 Effects of Dexmedetomidine as Adjunct to Pudendal Block for Pediatric Penile Surgery Not yet recruiting NCT02848157 Phase 4
4 Diagnosis of Urethral Stricture With Sono-urethrography vs Conventional Urethrography (SONO-URETHRA) Unknown status NCT01790776 Phase 3
5 Memokath® 044TW Stent for Treatment of Urethral Stricture Completed NCT00270504 Phase 3
6 Human Penile Allotransplantation Recruiting NCT02395497 Phase 2, Phase 3
7 Dorsal vs. Ventral Buccal Graft Dorsal vs. Ventral Buccal Graft Not yet recruiting NCT02551783 Phase 3
8 Effect of Mitomycin C on Urethral Stricture Recurrence After Internal Urethrotomy Unknown status NCT00918528 Phase 1, Phase 2
9 Effectiveness and Safety of Autologous Adipose-Derived Regenerative Cells for the Treatment of Urethral Strictures Unknown status NCT01889888 Phase 1, Phase 2
10 Role of Uttarbasti in the Management of Mutra Marga Sankoch (Urethral Stricture) Completed NCT00535717 Phase 2
11 Clinical Interest of the Temporary Urethral Stent Allium " Bulbar Urethral Stent " in the Treatment of Detrusor Sphincter Dyssynergia Completed NCT02323243 Phase 1, Phase 2
12 Effectiveness and Safety of Adipose-derived Regenerative Cells for Reduction of Risk of Bladder Neck Contracture Enrolling by invitation NCT02869061 Phase 1, Phase 2
13 Clostridium Histolyticum Collagenase Injection for Urethral Disease Not yet recruiting NCT02948842 Phase 2
14 Liquid Buccal Mucosa Graft Urethroplasty Not yet recruiting NCT03061344 Phase 1
15 Hemostasis During Hypospadias Surgery Unknown status NCT02268019
16 The Improvement in Uroflow and Postvoid Residual Urine After Urethral Meatotomy in Children With Meatal Stenosis Unknown status NCT01214525
17 Long Term Outcome of Hypospadias Repair Completed NCT02103712
18 Study Comparing Urinary Diversion (Transurethral/Suprapubic) After Radical Prostatectomy Completed NCT01465594
19 Effects of Thoracic Epidural Anesthesia on Lower Urinary Tract Function Completed NCT00790231
20 Does Thoracic Epidural Analgesia Influence Urinary Micturition by Patients Undergoing Thoracic Surgery? Completed NCT00976313
21 A Study of Dorsal Versus Ventral Buccal Mucosa Graft Onlay for Bulbar Urethroplasty Recruiting NCT02634619
22 Functional Outcome of Urethral Reconstructive Surgery Recruiting NCT01982136
23 ROBUST I Pilot Study Recruiting NCT03014726
24 Scandinavian Urethroplasty Study Recruiting NCT02321670
25 Effect of Caudal and Penile Block on Hypospadias Repair Complications Recruiting NCT02851290
26 Circumcision Versus Preputioplasty for BXO in Children Recruiting NCT02854995
27 Effect of Steroids on Post-Operative Complications Following Proximal Hypospadias Repair Recruiting NCT02162810
28 Foreskin Graft Tubularized Incised Plate Urethroplasty vs Tubularized Incised Plate for Primary Hypospadias (FGTIP-TIP) Not yet recruiting NCT02497963

Search NIH Clinical Center for Urethral Stricture

Genetic Tests for Urethral Stricture

Anatomical Context for Urethral Stricture

MalaCards organs/tissues related to Urethral Stricture:

39
Prostate, Skin, Kidney, Colon, Small Intestine, Testes, Brain

Publications for Urethral Stricture

Articles related to Urethral Stricture:

(show top 50) (show all 624)
id Title Authors Year
1
Anastomotic Urethroplasty for an Obstructing Calculus Within a Bulbar Urethral Diverticulum and Urethral Stricture. ( 27981035 )
2017
2
Cost-effective Strategies for the Management and Treatment of Urethral Stricture Disease. ( 27908365 )
2017
3
Re: Outpatient Ultrasound Urethrogram for Assessment of Anterior Urethral Stricture: Early Experience. ( 27979534 )
2017
4
Definition of Successful Treatment and Optimal Follow-up after Urethral Reconstruction for Urethral Stricture Disease. ( 27908363 )
2017
5
High-pressure balloon dilation for male anterior urethral stricture: single-center experience. ( 27604864 )
2016
6
Novel Concept and Method of Endoscopic Urethral Stricture Treatment Using Liquid Buccal Mucosal Graft. ( 27177425 )
2016
7
Female urethral stricture: a contemporary series. ( 27704202 )
2016
8
Multicenter Analysis of Urinary Urgency and Urge Incontinence in Patients with Anterior Urethral Stricture Disease: Before and after Urethroplasty. ( 27521692 )
2016
9
Early removal of urinary catheter after excision and primary anastomosis in anterior urethral stricture. ( 27274892 )
2016
10
The application of CT voiding urethrography in the evaluation of urethral stricture associated with fistula: a preliminary report. ( 27146077 )
2016
11
Use of an Absorbable Urethral Stent for the Management of a Urethral Stricture in a Stallion. ( 27558926 )
2016
12
Outpatient Ultrasound Urethrogram for Assessment of Anterior Urethral Stricture: Early Experience. ( 26993351 )
2016
13
Diversity of patient profile, urethral stricture, and other disease manifestations in a cohort of adult men with lichen sclerosus. ( 27195319 )
2016
14
Urethral Stricture Disease: Challenges and Ongoing Controversies. ( 27051419 )
2016
15
Vaginal-sparing ventral buccal mucosal graft urethroplasty for female urethral stricture: A novel modification of surgical technique. ( 27437540 )
2016
16
Penile Circular Fasciocutaneous (McAninch) Flap as an Option for Complex Anterior Urethral Stricture in Case of Non-Viable Buccal Mucosal Graft. ( 27630900 )
2016
17
Cultural background, non-therapeutic circumcision and the risk of meatal stenosis and other urethral stricture disease: Two nationwide register-based cohort studies in Denmark 1977-2013. ( 28017691 )
2016
18
Lateral-based Anterior Vaginal Wall Flap in the Treatment of Female Urethral Stricture: Efficacy and Safety. ( 27692474 )
2016
19
Re: Practice Patterns in the Treatment of Urethral Stricture among American Urologists: A Paradigm Change? ( 26887720 )
2016
20
Buccal mucosal graft urethroplasty for proximal bulbar urethral stricture: A revisit of the surgical technique and analysis of eleven consecutive cases. ( 27833245 )
2016
21
A Critical Evaluation of the Utility of Imaging After Urethroplasty for Bulbar Urethral Stricture Disease. ( 26923442 )
2016
22
Re: A Critical Evaluation of the Utility of Imaging after Urethroplasty for Bulbar Urethral Stricture Disease. ( 27845110 )
2016
23
The International Prostate Symptom Score (IPSS) is an Inadequate Tool to Screen for Urethral Stricture Recurrence after Anterior Urethroplasty. ( 27109599 )
2016
24
A Nationwide Assessment of the Emergency Department Management of Acute Urinary Retention Due to Urethral Stricture. ( 27658662 )
2016
25
Effect of Tadalafil on Prevention of Urethral Stricture After Urethral Injury: An Experimental Study. ( 26948527 )
2016
26
Adipose-derived Stem Cells Counteract Urethral Stricture Formation in Rats. ( 27156445 )
2016
27
Analysis of risk factors leading to postoperative urethral stricture and bladder neck contracture following transurethral resection of prostate. ( 27256185 )
2016
28
Current management of urethral stricture disease. ( 26941491 )
2016
29
Predictors of urethral stricture recurrence after endoscopic urethrotomy. ( 27207599 )
2016
30
Anterior Urethral Stricture Disease Negatively Impacts the Quality of Life of Family Members. ( 27034658 )
2016
31
Holmium laser vs. conventional (cold knife) direct visual internal urethrotomy for short-segment bulbar urethral stricture: Outcome analysis. ( 27790296 )
2016
32
Metastatic Malignant Melanoma of the Urinary Bladder in a Patient With Benign Prostatic Hyperplasia and Urethral Stricture. ( 27491496 )
2016
33
Incidence of Urethral Stricture in Patients with Spinal Cord Injury Treated with Clean Intermittent Self-Catheterization. ( 27566143 )
2016
34
Editorial - The case for excision and primary anastomotic urethroplasty for bulbar urethral stricture. ( 27716454 )
2016
35
Comparison Between End-to-end Anastomosis and Buccal Mucosa Graft in Short Segment Bulbar Urethral Stricture: a Meta-analysis Study. ( 27241540 )
2016
36
Re: Critical Analysis of the Use of Uroflowmetry for Urethral Stricture Disease Surveillance. ( 27845112 )
2016
37
A preliminary clinical study of endoscopic minimally-invasive surgery in urethral stricture complicated with false passage. ( 27652033 )
2016
38
Patient-Centered Treatment Decisions for Urethral Stricture: Conjoint Analysis Improves Surgical Decision-Making. ( 27645527 )
2016
39
The long-term results of temporary urethral stent placement for the treatment of recurrent bulbar urethral stricture disease? ( 27256191 )
2016
40
Management of the Recurrent Male Urethral Stricture. ( 26902627 )
2016
41
A comparative study of lingual mucosal graft urethroplasty with buccal mucosal graft urethroplasty in urethral stricture disease: An institutional experience. ( 27141184 )
2016
42
Adult urethral stricture: practice of Turkish urologists. ( 27256189 )
2016
43
Urethroplasty for treatment of long anterior urethral stricture: buccal mucosa graft versus penile skin graft-does the stricture length matter? ( 27401984 )
2016
44
Re: Dorsal versus Ventral Onlay Buccal Mucosal Graft Urethroplasty for Long-Segment Bulbar Urethral Stricture: A Prospective Randomized Study. ( 27191081 )
2016
45
Three-Dimensional Imaging of Urethral Stricture Disease and Urethral Pathology for Operative Planning. ( 27278565 )
2016
46
Treatment of long anterior urethral stricture associated to lichen sclerosus. ( 27816211 )
2016
47
Safety and efficacy of Intraurethral Mitomycin C Hydrogel for prevention of post-traumatic anterior urethral stricture recurrence after internal urethrotomy. ( 27093204 )
2016
48
Long-term management of luminal urethral stricture in women. ( 27026141 )
2016
49
Evaluation and management of anterior urethral stricture disease. ( 26918169 )
2016
50
W-V flap: a new technique for reconstruction of female distal urethral stricture using vestibular mucosa. ( 27170612 )
2016

Variations for Urethral Stricture

Expression for Urethral Stricture

Search GEO for disease gene expression data for Urethral Stricture.

Pathways for Urethral Stricture

Pathways related to Urethral Stricture according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.66 KLK3 SIRPA

GO Terms for Urethral Stricture

Biological processes related to Urethral Stricture according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 fibroblast growth factor receptor signaling pathway GO:0008543 9.16 CTGF FAT4
2 digestive tract development GO:0048565 8.96 CLMP FAT4
3 cell adhesion GO:0007155 8.92 CTGF FAT4 SCARF1 SIRPA

Sources for Urethral Stricture

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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