MCID: URT037
MIFTS: 35

Urethral Stricture

Categories: Nephrological diseases

Aliases & Classifications for Urethral Stricture

MalaCards integrated aliases for Urethral Stricture:

Name: Urethral Stricture 12 51 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:1829
ICD9CM 34 598.8
ICD10 32 N35

Summaries for Urethral Stricture

MalaCards based summary : Urethral Stricture is related to urethral syndrome and urinary tract obstruction. An important gene associated with Urethral Stricture is KLK3 (Kallikrein Related Peptidase 3), and among its related pathways/superpathways is Adhesion. The drugs Pharmaceutical Solutions and Lidocaine have been mentioned in the context of this disorder. Affiliated tissues include prostate, skin and kidney.

Wikipedia : 72 A urethral stricture is a narrowing of the urethra caused by injury, instrumentation, infection and... more...

Related Diseases for Urethral Stricture

Diseases related to Urethral Stricture via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 54)
# Related Disease Score Top Affiliating Genes
1 urethral syndrome 32.5 BCL2L10 KLK3
2 urinary tract obstruction 29.9 CTGF KLK3
3 infective urethral stricture 12.1
4 urethritis 11.2
5 pigmentary disorder, reticulate, with systemic manifestations, x-linked 11.2
6 prostatitis 10.6
7 mucositis 10.5
8 hypospadias 10.4
9 lichen sclerosus 10.3
10 prostate cancer 10.2
11 balanitis 10.2
12 balanitis xerotica obliterans 10.2
13 vaginitis 10.2
14 leukoplakia of penis 10.2
15 prostatic cyst 10.2 BCL2L10 KLK3
16 bladder neck obstruction 10.1 KLK3 SIRPA
17 polyarteritis nodosa, childhood-onset 10.1
18 posterior urethral valves 10.1
19 prostatic hyperplasia, benign 10.0
20 cystitis 10.0
21 squamous cell carcinoma 10.0
22 urinary system disease 10.0 CTGF KLK3
23 male reproductive organ cancer 9.9 KLK3 SHC4
24 fibrosis of extraocular muscles, congenital, 1 9.9
25 spinal cord injury 9.9
26 impotence 9.9
27 neuropathy 9.9
28 eosinophilic cystitis 9.9
29 schistosoma mansoni infection, susceptibility/ 9.8
30 ureterocele 9.8
31 transsexuality 9.8
32 episodic pain syndrome, familial, 1 9.8
33 metabolic encephalomyopathic crises, recurrent, with rhabdomyolysis, cardiac arrhythmias, and neurodegeneration 9.8
34 brain injury 9.8
35 end stage renal failure 9.8
36 hemangioma 9.8
37 malignant hypertension 9.8
38 transsexualism 9.8
39 schistosomiasis 9.8
40 lymphangioma 9.8
41 melanoma 9.8
42 epidermolysis bullosa 9.8
43 junctional epidermolysis bullosa 9.8
44 ischemia 9.8
45 urethra squamous cell carcinoma 9.8
46 primary syphilis 9.8
47 syphilis 9.8
48 neuronitis 9.8
49 priapism 9.8
50 urethral diverticulum 9.8

Comorbidity relations with Urethral Stricture via Phenotypic Disease Network (PDN): (show all 27)


Acute Cystitis Acute Kidney Failure
Balanoposthitis Bladder Cancer
Bladder Neck Obstruction Chronic Kidney Failure
Chronic Myocardial Ischemia Cystitis
Cystitis Cystica Deficiency Anemia
Epididymo-Orchitis Hydronephrosis
Ischemic Heart Disease Nephrolithiasis, X-Linked Recessive, with Renal Failure
Neurogenic Bladder Peyronie's Disease
Prostate Calculus Prostate Cancer
Prostatic Hypertrophy Prostatitis
Radiation Cystitis Trigonitis
Ureterolithiasis Urethral Calculus
Urethral Gland Abscess Urethritis
Urinary Tract Obstruction

Graphical network of the top 20 diseases related to Urethral Stricture:



Diseases related to Urethral Stricture

Symptoms & Phenotypes for Urethral Stricture

Drugs & Therapeutics for Urethral Stricture

Drugs for Urethral Stricture (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 35)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Pharmaceutical Solutions Phase 3
2
Lidocaine Approved, Vet_approved Phase 2 137-58-6 3676
3 Alkylating Agents Phase 1, Phase 2
4 Anti-Bacterial Agents Phase 1, Phase 2
5 Antibiotics, Antitubercular Phase 1, Phase 2
6 Mitomycins Phase 1, Phase 2
7 Nucleic Acid Synthesis Inhibitors Phase 1, Phase 2
8 Anesthetics Phase 1, Phase 2
9 Peripheral Nervous System Agents Phase 2
10 Anesthetics, Local Phase 2
11 Central Nervous System Depressants Phase 2
12 Anti-Arrhythmia Agents Phase 2
13 Diuretics, Potassium Sparing Phase 2
14 Sodium Channel Blockers Phase 2
15 Fibrin Tissue Adhesive Phase 1
16
Epinephrine Approved, Vet_approved 51-43-4 5816
17 Racepinephrine Approved 329-65-7
18
Paclitaxel Approved, Vet_approved 33069-62-4 36314
19
Menthol Approved Early Phase 1 2216-51-5 16666
20
Ropivacaine Approved 84057-95-4 175805 71273
21 Adrenergic Agents
22 Adrenergic Agonists
23 Adrenergic alpha-Agonists
24 Adrenergic beta-Agonists
25 Anti-Asthmatic Agents
26 Autonomic Agents
27 Bronchodilator Agents
28 Coagulants
29 Epinephryl borate
30 Hemostatics
31 Mydriatics
32 Neurotransmitter Agents
33 Respiratory System Agents
34 Vasoconstrictor Agents
35 Albumin-Bound Paclitaxel

Interventional clinical trials:

(show all 22)

# Name Status NCT ID Phase Drugs
1 Efficiency of Cold vs. Laser Internal Urethrotomy Treatment of Urethral Strictures Unknown status NCT01196572 Phase 4
2 Diagnosis of Urethral Stricture With Sono-urethrography vs Conventional Urethrography (SONO-URETHRA) Unknown status NCT01790776 Phase 3
3 Memokath® 044TW Stent for Treatment of Urethral Stricture Completed NCT00270504 Phase 3
4 Effect of Mitomycin C on Urethral Stricture Recurrence After Internal Urethrotomy Unknown status NCT00918528 Phase 1, Phase 2 Mitomycin C - local injection
5 Effectiveness and Safety of Autologous Adipose-Derived Regenerative Cells for the Treatment of Urethral Strictures Unknown status NCT01889888 Phase 1, Phase 2
6 Role of Uttarbasti in the Management of Mutra Marga Sankoch (Urethral Stricture) Completed NCT00535717 Phase 2
7 Clostridium Histolyticum Collagenase Injection for Urethral Disease Not yet recruiting NCT02948842 Phase 2 Clostridium Histolyticum Collagenase;Lidocaine
8 Safety and Feasibility Study of Autologous Engineered Urethral Constructs for the Treatment of Strictures Recruiting NCT03258658 Phase 1
9 Liquid Buccal Mucosa Graft Urethroplasty Not yet recruiting NCT03061344 Phase 1
10 Hemostasis During Hypospadias Surgery Unknown status NCT02268019 epinephrine injection
11 The Improvement in Uroflow and Postvoid Residual Urine After Urethral Meatotomy in Children With Meatal Stenosis Unknown status NCT01214525
12 PVP Compared to TURP for the Treatment of Benign Hyperplasia of the Prostate Completed NCT00527371
13 Re-establishing Flow Via Drug Coated Balloon For The Treatment Of Urethral Stricture Disease Recruiting NCT03270384
14 A Study of Dorsal Versus Ventral Buccal Mucosa Graft Onlay for Bulbar Urethroplasty Recruiting NCT02634619
15 Tissue-engineered Construct Based on Buccal Mucosa Cells and Matrix From Collagen and Polylactoglycolide Fibers Recruiting NCT03205670 Early Phase 1
16 Functional Outcome of Urethral Reconstructive Surgery Recruiting NCT01982136
17 Dorsal vs. Ventral Buccal Graft Dorsal vs. Ventral Buccal Graft Recruiting NCT02551783
18 Scandinavian Urethroplasty Study Recruiting NCT02321670
19 A Prospective Evaluation of the Catheter Science M3 "Mini Catheter" for Patients With Prostatic Recruiting NCT03339076
20 Effect of Caudal and Penile Block on Hypospadias Repair Complications Recruiting NCT02851290
21 ROBUST I Pilot Study Active, not recruiting NCT03014726
22 Transgender Post-reassignment Urogynecologic Measures and Perceptions Not yet recruiting NCT03293771

Search NIH Clinical Center for Urethral Stricture

Genetic Tests for Urethral Stricture

Anatomical Context for Urethral Stricture

MalaCards organs/tissues related to Urethral Stricture:

38
Prostate, Skin, Kidney, Spinal Cord, Colon, Small Intestine, Brain

Publications for Urethral Stricture

Articles related to Urethral Stricture:

(show top 50) (show all 657)
# Title Authors Year
1
Re: Low Testosterone Levels Result in Decreased Periurethral Vascularity via an Androgen Receptor-Mediated Process: Pilot Study in Urethral Stricture Tissue. ( 29357549 )
2018
2
microRNA expression profiles of scar and normal tissue from patients with posterior urethral stricture caused by pelvic fracture urethral distraction defects. ( 29436608 )
2018
3
Hypoandrogenism is Prevalent in Males with Urethral Stricture Disease and is Associated with Longer Strictures. ( 29378279 )
2018
4
A novel heterozygous GLI2 mutation in a patient with congenital urethral stricture and renal hypoplasia/dysplasia leading to end-stage renal failure. ( 29318530 )
2018
5
Re: Urethral Stricture Outcomes after Artificial Urinary Sphincter Cuff Erosion: Results from a Multicenter Retrospective Analysis. ( 29357550 )
2018
6
Management of long segment anterior urethral stricture (a8Y 8cm) using buccal mucosal (BM) graft and penile skin (PS) flap: outcome and predictors of failure. ( 29211404 )
2018
7
AT<sub>1</sub>expression in human urethral stricture tissue. ( 28979891 )
2017
8
Re: Outpatient Ultrasound Urethrogram for Assessment of Anterior Urethral Stricture: Early Experience. ( 27979534 )
2017
9
The predictive value of platelet to lymphocyte and neutrophil to lymphocyte ratio in determining urethral stricture after transurethral resection of prostate. ( 28861306 )
2017
10
Definition of Successful Treatment and Optimal Follow-up after Urethral Reconstruction for Urethral Stricture Disease. ( 27908363 )
2017
11
Cost-effective Strategies for the Management and Treatment of Urethral Stricture Disease. ( 27908365 )
2017
12
Management of Urethral Stricture and Bladder Neck Contracture Following Primary and Salvage Treatment of Prostate Cancer. ( 28776126 )
2017
13
Three-Dimensional Computerized Model Based on the Sonourethrogram: A Novel Technique for Evaluating the Anterior Urethral Stricture. ( 28866465 )
2017
14
A novel method in decision making for the diagnosis of anterior urethral stricture: using methylene blue dye. ( 29201515 )
2017
15
Double inlay plus ventral onlay buccal mucosa graft for simultaneous penile and bulbar urethral stricture. ( 29135409 )
2017
16
Management of bladder neck stenosis and urethral stricture and stenosis following treatment for prostate cancer. ( 28791228 )
2017
17
Incidence and Management of Lower Urinary Tract Symptoms After Urethral Stricture Repair. ( 28718163 )
2017
18
Comparison of Diagnostic Value of Sonourethrography with Retrograde Urethrography in Diagnosis of Anterior Urethral Stricture. ( 28698753 )
2017
19
Urethroplasty and Quality of Life: Psychometric Validation of a Dutch Version of the Urethral Stricture Surgery Patient Reported Outcome Measures. ( 28850951 )
2017
20
Squamous Cell Carcinoma Penis in a Case of Urethral Stricture Due to Lichen Sclerosus Balanitis Xerotica Obliterans: A Case Report and Review of Literature. ( 28892974 )
2017
21
Substitution urethroplasty using oral mucosa graft for male anterior urethral stricture disease: Current topics and reviews. ( 28600871 )
2017
22
Fulfilling Patient Expectations of Urethral Stricture Surgery. ( 28822234 )
2017
23
Substitution urethroplasty for anterior urethral stricture repair: comparison between lingual mucosa graft and pedicled skin flap. ( 28738760 )
2017
24
Management of urethral stricture: High-pressure balloon dilation versus optical internal urethrotomy. ( 29119701 )
2017
25
Initial experience with Alliuma8c stent in the management of bulbar urethral stricture. ( 28791227 )
2017
26
Re: Outcomes for Management of Lichen Sclerosus Urethral Strictures by 3 Different Techniques. ( 29370640 )
2017
27
Understanding patients' preferences for surgical management of urethral stricture disease. ( 28664240 )
2017
28
Anastomotic Urethroplasty for an Obstructing Calculus Within a Bulbar Urethral Diverticulum and Urethral Stricture. ( 27981035 )
2017
29
Ventral-onlay buccal mucosa graft substitution urethroplasty for urethral stricture in women. ( 28749039 )
2017
30
Re: Incidence of Urethral Stricture in Patients with Spinal Cord Injury Treated with Clean Intermittent Self-Catheterization. ( 28905775 )
2017
31
Anti-fibrotic function of Cu-bearing stainless steel for reducing recurrence of urethral stricture after stent implantation. ( 29068537 )
2017
32
A 10-Year Review of Urethral Stricture Management in Irrua, Nigeria. ( 29089737 )
2017
33
Re: Comprehensive Qualitative Assessment of Urethral Stricture Disease: Toward the Development of a Patient Centered Outcome Measure. ( 28890244 )
2017
34
Editorial Comment to Substitution urethroplasty using oral mucosa graft for male anterior urethral stricture disease: Current topics and reviews. ( 28626935 )
2017
35
Re: Analysis of Risk Factors Leading to Postoperative Urethral Stricture and Bladder Neck Contracture following Transurethral Resection of Prostate. ( 28905747 )
2017
36
Incidence and predictors of complications due to urethral stricture in patients awaiting urethroplasty. ( 28899769 )
2017
37
Re: Cultural background, non-therapeutic circumcision and the risk of meatal stenosis and other urethral stricture disease: Two nationwide register-based cohort studies in Denmark 1977-2013. ( 28869139 )
2017
38
Patient-Centered Treatment Decisions for Urethral Stricture: Conjoint Analysis Improves Surgical Decision-Making. ( 27645527 )
2016
39
Incidence of Urethral Stricture in Patients with Spinal Cord Injury Treated with Clean Intermittent Self-Catheterization. ( 27566143 )
2016
40
Adipose-derived Stem Cells Counteract Urethral Stricture Formation in Rats. ( 27156445 )
2016
41
Female urethral stricture: a contemporary series. ( 27704202 )
2016
42
Holmium laser vs. conventional (cold knife) direct visual internal urethrotomy for short-segment bulbar urethral stricture: Outcome analysis. ( 27790296 )
2016
43
A comparative study of lingual mucosal graft urethroplasty with buccal mucosal graft urethroplasty in urethral stricture disease: An institutional experience. ( 27141184 )
2016
44
Management of the Recurrent Male Urethral Stricture. ( 26902627 )
2016
45
Re: Critical Analysis of the Use of Uroflowmetry for Urethral Stricture Disease Surveillance. ( 27845112 )
2016
46
Long-term management of luminal urethral stricture in women. ( 27026141 )
2016
47
W-V flap: a new technique for reconstruction of female distal urethral stricture using vestibular mucosa. ( 27170612 )
2016
48
Use of an Absorbable Urethral Stent for the Management of a Urethral Stricture in a Stallion. ( 27558926 )
2016
49
Bulbar urethral stricture: How to optimise the use of buccal mucosal grafts. ( 27489734 )
2016
50
Analysis of risk factors leading to postoperative urethral stricture and bladder neck contracture following transurethral resection of prostate. ( 27256185 )
2016

Variations for Urethral Stricture

Expression for Urethral Stricture

Search GEO for disease gene expression data for Urethral Stricture.

Pathways for Urethral Stricture

Pathways related to Urethral Stricture according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.88 CTGF KLK3 SIRPA

GO Terms for Urethral Stricture

Biological processes related to Urethral Stricture according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 fibroblast growth factor receptor signaling pathway GO:0008543 8.96 CTGF FAT4
2 cell adhesion GO:0007155 8.92 CTGF FAT4 SCARF1 SIRPA

Sources for Urethral Stricture

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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