Aliases & Classifications for Urethral Syndrome

Summaries for Urethral Syndrome

MedlinePlus : 41 the urethra is the tube that allows urine to pass out of the body. in men, it's a long tube that runs through the penis. it also carries semen in men. in women, it's short and is just above the vagina. urethral problems may happen due to aging, illness, or injury. they include urethral cancer - a rare cancer that happens more often in men urethral stricture - a narrowing of the opening of the urethra urethritis - inflammation of the urethra, sometimes caused by infection urethral problems may cause pain or difficulty passing urine. you may also have bleeding or discharge from the urethra. doctors diagnose urethral problems using different tests. these include urine tests, x-rays and an examination of the urethra with a scope called a cystoscope. treatment depends on the cause of the problem. it may include medicines and, in severe cases, surgery.

MalaCards based summary : Urethral Syndrome, also known as urethral diseases, is related to urethritis and capillary leak syndrome, and has symptoms including pain in urethra An important gene associated with Urethral Syndrome is MRAP (Melanocortin 2 Receptor Accessory Protein), and among its related pathways/superpathways is Primary immunodeficiency. The drugs Solifenacin succinate and Acetylcholine have been mentioned in the context of this disorder. Affiliated tissues include testes, prostate and colon.

Disease Ontology : 12 A urinary system disease that is located in the urethra.

Wikipedia : 72 Urethral syndrome is characterised by a set of symptoms typically associated with lower urinary tract... more...

Related Diseases for Urethral Syndrome

Diseases related to Urethral Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 158)
id Related Disease Score Top Affiliating Genes
1 urethritis 10.9
2 capillary leak syndrome 10.8 BCKDHA MRAP
3 azoospermia 10.8 HPD MRAP
4 tick-borne relapsing fever 10.7 MRAP PHB2
5 acute maxillary sinusitis 10.7 MRAP PHB2
6 urticaria 10.7 MRAP PHB2
7 kidney cortex necrosis 10.7 MRAP PHB2
8 neuronal ceroid-lipofuscinoses 10.7 MRAP PHB2
9 uterine corpus epithelioid leiomyoma 10.6 KLK3 SAMHD1
10 hypersecretion glaucoma 10.6 BCL2L10 KLK3
11 allergic bronchopulmonary aspergillosis 10.6 BCKDHA KLK3
12 mononeuritis of upper limb 10.6 BCL2L10 KLK3
13 acute allergic mucoid otitis media 10.6 MRAP SAMHD1
14 hypochondriasis 10.5 KIDINS220 KLK3
15 fibular collateral ligament bursitis 10.5 KIDINS220 KLK3
16 primary lacrimal atrophy 10.5 CD79A MRAP
17 inclusion conjunctivitis 10.4 CD79A MRAP
18 malignant hypertensive renal disease 10.3 CD40LG MRAP
19 infiltrating angiolipoma 10.3 CD40LG MRAP
20 infectious anterior uveitis 10.3 CD40LG MRAP
21 barbiturate dependence 10.2 CD79A MRAP MT-TG
22 estrogen excess 10.2 CD40LG SAMHD1
23 fetal akinesia deformation sequence 10.1 CD40LG MT-TG
24 cryptococcosis 10.1 CD40LG MRAP
25 urethral gland abscess 10.1
26 trench fever 10.0 CD40LG SAMHD1
27 alcoholic neuropathy 10.0 CD40LG CD79A
28 calloso-genital dysplasia 10.0 CD40LG CD79A
29 variola major 10.0 CD40LG CD79A
30 mu chain disease 10.0 CD40LG CD79A
31 rabies 10.0 CD40LG CD79A
32 familial retinoblastoma 10.0 CD40LG CD79A
33 anti-basement membrane glomerulonephritis 10.0 CD40LG CD79A
34 microinvasive cervical squamous cell carcinoma 10.0 CD40LG CD79A
35 fetal erythroblastosis 10.0 CD40LG CD79A
36 spinal canal and spinal cord meningioma 10.0 CD40LG CD79A
37 trichostrongyloidiasis 10.0 CD40LG CD79A
38 leukodystrophy 10.0 CD40LG CD79A
39 retinal microaneurysm 9.9 CD40LG CD79A
40 heart septal defect 9.9 CD40LG CD79A
41 plasmodium falciparum malaria 9.9 CD40LG MRAP PHB2
42 cryptorchidism arachnodactyly mental retardation 9.9 CD40LG CD79A
43 vulvar sarcoma 9.9 CD40LG MRAP PHB2
44 acute kidney tubular necrosis 9.9 CD40LG CD79A
45 secretory meningioma 9.9 CD40LG CD79A
46 hodgkin's lymphoma, nodular sclerosis 9.9 CD40LG CD79A
47 imperforate oropharynx-costo vetebral anomalies 9.9 CD40LG CD79A
48 malignant otitis externa 9.9 CD40LG CD79A
49 transient hypogammaglobulinemia 9.9 CD40LG CD79A
50 benign epilepsy with centrotemporal spikes 9.9 CD40LG CD79A

Comorbidity relations with Urethral Syndrome via Phenotypic Disease Network (PDN):


Acute Cystitis

Graphical network of the top 20 diseases related to Urethral Syndrome:



Diseases related to Urethral Syndrome

Symptoms & Phenotypes for Urethral Syndrome

UMLS symptoms related to Urethral Syndrome:


pain in urethra

Drugs & Therapeutics for Urethral Syndrome

Drugs for Urethral Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 44)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Solifenacin succinate Phase 4,Phase 2 242478-38-2
2
Acetylcholine Approved Phase 2, Phase 3 51-84-3 187
3
Fluconazole Approved Phase 3 86386-73-4 3365
4
Metronidazole Approved Phase 3 443-48-1 4173
5
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
6
Secnidazole Approved Phase 3 3366-95-8
7 abobotulinumtoxinA Phase 2, Phase 3
8 Botulinum Toxins Phase 2, Phase 3
9 Botulinum Toxins, Type A Phase 2, Phase 3
10 Cholinergic Agents Phase 2, Phase 3
11 incobotulinumtoxinA Phase 2, Phase 3
12 Neuromuscular Agents Phase 2, Phase 3
13 Neurotransmitter Agents Phase 2, Phase 3
14 onabotulinumtoxinA Phase 2, Phase 3
15 Peripheral Nervous System Agents Phase 2, Phase 3
16 Antifungal Agents Phase 3
17 Anti-Infective Agents Phase 3,Phase 1
18 Antiparasitic Agents Phase 3
19 Antiprotozoal Agents Phase 3
20 Cytochrome P-450 CYP2C9 Inhibitors Phase 3
21 Cytochrome P-450 Enzyme Inhibitors Phase 3
22 Hormone Antagonists Phase 3
23 Hormones Phase 3
24 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
25 Steroid Synthesis Inhibitors Phase 3
26 Pharmaceutical Solutions Phase 3
27
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 2 437-38-7 3345
28
Pancuronium Approved Phase 2 15500-66-0 27350 441289
29 Anesthetics Phase 2
30 Cholinergic Antagonists Phase 2
31 Muscarinic Antagonists Phase 2
32
Carboplatin Approved Phase 1 41575-94-4 10339178 498142 38904
33
Paclitaxel Approved, Vet_approved Phase 1 33069-62-4 36314
34
Trastuzumab Approved, Investigational Phase 1 180288-69-1 9903
35 Adjuvants, Immunologic Phase 1
36 Albumin-Bound Paclitaxel Phase 1
37 Angiogenesis Inhibitors Phase 1
38 Angiogenesis Modulating Agents Phase 1
39 Antimitotic Agents Phase 1
40 Antineoplastic Agents, Phytogenic Phase 1
41 Interleukin-12 Phase 1
42
Hyaluronic acid Approved, Vet_approved 9004-61-9 53477741 24759
43 Central Nervous System Depressants
44 Tolterodine tartrate 124937-52-6

Interventional clinical trials:

(show all 28)

id Name Status NCT ID Phase Drugs
1 Evaluating the Change of Overactive Bladder Symptoms in Women Post Pubovaginal Sling Procedure for Stress Incontinence Completed NCT01194999 Phase 4
2 Mechanical Nerve Stimulation in the Treatment of Post Prostatectomy Incontinence Unknown status NCT01540656 Phase 3
3 Botulinum Toxin A Injections in Patients With Fowler's Syndrome Completed NCT02428881 Phase 2, Phase 3 onabotulinumtoxinA
4 Safety and Clinical and Microbiological Efficacy of the Combination of Fluconazole and Secnidazole for the Treatment of Symptomatic Vaginal Discharge Completed NCT02111629 Phase 3 Fluconazole and Secnidazole
5 Botulinum Toxin Type A for the Treatment of Male Chronic Pelvic Pain Syndrome Terminated NCT00464373 Phase 3 Botulinum Toxin Type A;Placebo
6 Transcutaneous Mechanical Nerve Stimulation in the Treatment of Incontinence Terminated NCT01366066 Phase 3
7 Transcutaneous Mechanical Nerve Stimulation (TMNS) by Vibration in the Treatment of Incontinence Withdrawn NCT00695058 Phase 3
8 Safety And Efficacy Of Solifenacin In Men With Overactive Bladder (OAB) And Detrusor Underactivity Completed NCT00441428 Phase 2 solifenacin
9 Fetal Cystoscopy Versus Vesico-amniotic Shunting in Severe Lower Urinary Tract Obstructions Not yet recruiting NCT01552824 Phase 2
10 SPL7013 Gel - Male Tolerance Study Completed NCT00370357 Phase 1 3% w/w SPL7013 Gel (VivaGel™)
11 Interleukin-12 and Trastuzumab in Treating Patients With Cancer That Has High Levels of HER2/Neu Completed NCT00004074 Phase 1
12 Cystoscopy Plus Urethral Dilatation Versus Cystoscopy Alone in Women With Overactive Bladder Syndrome and Impaired Voiding Unknown status NCT00839969
13 Efficacy of Extracorporal Shock Wave Therapy in Patient With Chronic Non-bacterial Prostatitis / Chronic Pelvic Pain Syndrome Unknown status NCT01714830
14 Comparison of Electrical Pudendal Nerve Stimulation and Tolterodine Tartrate for Urgency-Frequency Syndrome in Women Completed NCT02723279 TT
15 A Comparison of Electrical Ilioinguinal Nerve Stimulation With Intravesical Irrigation for Bladder Pain Syndrome Completed NCT02856022
16 Colonization of the Female Urethra With Mycoplasma Hominis, Ureaplasma Urealyticum, Chlamydia Trachomatis, or Neisseria Gonorrhea in Patients With Lower Urinary Tract Symptoms Completed NCT01559623
17 PREMAPIV : Intravesical Pressure Variation at Different Bladder Instillation Volumes in Newborn Children Completed NCT01296724
18 Pelvic Floor Muscle Training (PFMT) in Treatment and Prevention of POP (POP Study) Completed NCT00271297
19 Efficacy of Electrical Pudendal Nerve Stimulation for Neurogenic Lower Urinary Tract Dysfunction Completed NCT02554201
20 The Role of microRNAs in Organ Remodeling in Lower Urinary Tract Dysfunction Completed NCT01482676
21 Correlations of 3D Urethral and Paraurethral Sonographic Findings With Urodynamic Studies, Lower Urinary Tract Symptoms & Sexual Dysfunction in Female Patients With Lower Urinary Tract Symptoms. Recruiting NCT01884753
22 A Retrospective Analysis of Spinal Anaesthesia for TURBT Procedures in Elderly Patients Recruiting NCT03221829
23 Standardized Prenatal Clinical Care for LUTO Recruiting NCT02315521
24 Clinical and Urodynamic Predictors for Sacral Neuromodulation Outcomes in Overactive Bladder Active, not recruiting NCT03156088
25 Chronic Inflammatory Condition of the Male Genital Tract Active, not recruiting NCT01732172
26 Fetal Cystoscopy for Lower Urinary Tract Obstruction Terminated NCT02446184
27 A Follow-net Investigation of a Randomised Study of Cystoscopy and Urethral Dilatation Versus Cystoscopy Alone in Women With Overactive Bladder Syndrome and Impaired Voiding Withdrawn NCT02297178
28 Microbiome of Urologic Chronic Pelvic Pain Syndrome Withdrawn NCT03027076

Search NIH Clinical Center for Urethral Syndrome

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: urethral diseases

Genetic Tests for Urethral Syndrome

Genetic tests related to Urethral Syndrome:

id Genetic test Affiliating Genes
1 Abnormality of the Urethra 29

Anatomical Context for Urethral Syndrome

MalaCards organs/tissues related to Urethral Syndrome:

39
Testes, Prostate, Colon, Cervix

Publications for Urethral Syndrome

Articles related to Urethral Syndrome:

(show top 50) (show all 131)
id Title Authors Year
1
Gonococcal Conjunctivitis Despite Successful Treatment of Male Urethritis Syndrome. ( 26760182 )
2016
2
Epidemiology and laboratory characteristics of Trichomonas vaginalis infection in Croatian men with and without urethritis syndrome: a case-control study. ( 25568091 )
2015
3
A prospective study to evaluate the efficacy of cistiquer in improving lower urinary tract symptoms in females with urethral syndrome. ( 25034330 )
2014
4
The role of a leaky epithelium and potassium in the generation of bladder symptoms in interstitial cystitis/overactive bladder, urethral syndrome, prostatitis and gynaecological chronic pelvic pain. ( 21176078 )
2011
5
The detection of urethritis pathogens among patients with the male urethritis syndrome, genital ulcer syndrome and HIV voluntary counselling and testing clients: should South Africa's syndromic management approach be revised? ( 18192290 )
2008
6
Urethral syndrome: response to alpha-adrenergic blocking agents. ( 16261427 )
2006
7
Treatment of urethral syndrome: a prospective randomized study with Nd:YAG laser. ( 16493214 )
2006
8
Treatment of post-menopausal urethral syndrome with the formula niao chang shu--a report of 40 cases. ( 15119161 )
2004
9
Dr. Li Yueqing's experience in treating female urethral syndrome. ( 15270256 )
2004
10
Transabdominal vesical sonography of urethral syndrome and stress incontinence. ( 12534925 )
2003
11
Prostatitis, interstitial cystitis, chronic pelvic pain, and urethral syndrome share a common pathophysiology: lower urinary dysfunctional epithelium and potassium recycling. ( 14665339 )
2003
12
Electric acupuncture in the treatment of 36 cases of female urethral syndrome. ( 14719301 )
2003
13
Treatment of female urethral syndrome refractory to antibiotics. ( 12402379 )
2002
14
The incidence of Chlamydia trachomatis in women with urethral syndrome. ( 11695072 )
2001
15
Azithromycin and doxycycline in the treatment of female patients with acute urethral syndrome caused by Ureaplasma urealyticum: significance of duration of clinical symptoms. ( 11822223 )
2001
16
Intravesical potassium sensitivity in patients with interstitial cystitis and urethral syndrome. ( 11248610 )
2001
17
Duration of clinical symptoms in female patients with acute urethral syndrome caused by Chlamydia trachomatis treated with azithromycin or doxycycline. ( 11330365 )
2001
18
Comparative analysis of azithromycin and doxycycline efficacy in the treatment of female patients with acute urethral syndrome caused by Ureaplasma urealyticum. ( 10789560 )
2000
19
Duration of clinical symptoms in female patients with acute urethral syndrome caused by Ureaplasma urealyticum treated with azithromycin or doxycycline. ( 11154040 )
2000
20
Urethral syndrome and associated risk factors related to obstetrics and gynecology. ( 10221602 )
1999
21
Equal symptomatic outcome after antibacterial treatment of acute lower urinary tract infection and the acute urethral syndrome in adult women. ( 10555247 )
1999
22
Urinary bacterial flora of women with urethral syndrome and interstitial cystitis. ( 9852391 )
1999
23
Study on acupuncture and moxibustion therapy for female urethral syndrome. ( 10437230 )
1998
24
Female urethral syndrome. A female prostatitis? ( 8686301 )
1996
25
1-day azithromycin was as effective as 7-day doxycycline for nongonococcal urethritis syndrome in men. ( 8912627 )
1996
26
Azithromycin for empirical treatment of the nongonococcal urethritis syndrome in men. A randomized double-blind study. ( 7629982 )
1995
27
Evolving strategies for management of the nongonococcal urethritis syndrome. ( 7629989 )
1995
28
Fibromyalgia associated with female urethral syndrome. ( 8187451 )
1994
29
Urethral syndrome: clinical results with antibiotics alone or combined with estrogen. ( 7957464 )
1994
30
The urethral syndrome: a controlled evaluation. J Psychosom Res 1993; 37: 737-743. ( 8027965 )
1994
31
The urethral syndrome and its management. ( 7928838 )
1994
32
The urethral syndrome: a controlled evaluation. ( 8229904 )
1993
33
The urethral syndrome--why what we do works, or doesn't. ( 1479977 )
1992
34
A psychophysiological evaluation of female urethral syndrome: evidence for a muscular abnormality. ( 1625341 )
1992
35
Surgical repair of hypospadias in women with symptoms of urethral syndrome. ( 1569664 )
1992
36
The painful bladder: urethral syndrome and interstitial cystitis. ( 2130959 )
1990
37
Genitourinary manifestations of fibrositis: an increased association with the female urethral syndrome. ( 2319522 )
1990
38
Prostatodynia or painful male urethral syndrome? ( 2385883 )
1990
39
The urethral syndrome: myth or reality? A commentary. ( 2233643 )
1990
40
Pharmacokinetic data and therapeutic efficacy of miocamycin: serum, urinary and prostatic levels. Therapeutic aspects in acute urethral syndrome and non-gonococcal urethritis. ( 16312542 )
1989
41
Urethral syndrome. A comparison of different treatment modalities. ( 2926732 )
1989
42
Cryosurgery versus dilation and massage for the treatment of recurrent urethral syndrome. ( 2810238 )
1989
43
Interstitial cystitis and the urethral syndrome: a possible answer. ( 2670041 )
1989
44
Urethral syndrome: a study in psychosomatic urology. ( 2486388 )
1989
45
Urethral syndrome: patient suggestions. ( 3420419 )
1988
46
Efficacy of miocamycin in the therapy of non-specific genital infections (NSGI): non-gonococcal urethritis (NGU) and acute urethral syndrome (AUS). ( 3259948 )
1988
47
The urethral syndrome. ( 3170107 )
1988
48
Sexually transmitted diseases in women with urethral syndrome. ( 2903082 )
1988
49
The urethral syndrome. ( 3055620 )
1988
50
The acute urethral syndrome in routine practice. ( 3494789 )
1987

Variations for Urethral Syndrome

Expression for Urethral Syndrome

Search GEO for disease gene expression data for Urethral Syndrome.

Pathways for Urethral Syndrome

Pathways related to Urethral Syndrome according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.19 CD40LG CD79A

GO Terms for Urethral Syndrome

Biological processes related to Urethral Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 B cell proliferation GO:0042100 8.62 CD40LG CD79A

Sources for Urethral Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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