MCID: URT001
MIFTS: 41

Urethritis malady

Categories: Nephrological diseases

Aliases & Classifications for Urethritis

Aliases & Descriptions for Urethritis:

Name: Urethritis 12 42 14 69
Non-Gonococcal Urethritis 12 69
Nongonococcal Urethritis 12 52
Nonspecific Urethritis 69

Classifications:



External Ids:

Disease Ontology 12 DOID:1343
ICD9CM 35 597.80
MeSH 42 D014526
NCIt 47 C26904

Summaries for Urethritis

MalaCards based summary : Urethritis, also known as non-gonococcal urethritis, is related to chlamydia and hydronephrosis. An important gene associated with Urethritis is DEFB4A (Defensin Beta 4A), and among its related pathways/superpathways is Primary immunodeficiency. The drugs Azithromycin and Doxycycline have been mentioned in the context of this disorder. Affiliated tissues include prostate, testes and kidney.

Wikipedia : 71 Urethritis is inflammation of the urethra. The most common symptom is painful or difficult urination. It... more...

Related Diseases for Urethritis

Diseases related to Urethritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 377)
id Related Disease Score Top Affiliating Genes
1 chlamydia 30.8 CD40LG HSPD1
2 hydronephrosis 29.9 CD40LG HSPD1
3 endocarditis 29.4 CD40LG CD79A
4 syphilis 29.4 CD40LG CD79A EXTL3
5 megacolon 29.3 CD40LG CD79A
6 urethral syndrome 12.4
7 urethral stricture 12.3
8 posterior urethral valves 12.3
9 urethral diverticulum 12.2
10 urethral cancer 12.1
11 urethral calculus 11.9
12 urethral obstruction sequence 11.9
13 female urethral cancer 11.9
14 urethral gland abscess 11.9
15 male urethral cancer 11.8
16 urethral false passage 11.8
17 anterior urethral valve 11.8
18 urethral benign neoplasm 11.8
19 urethral verrucous carcinoma 11.7
20 urethral intrinsic sphincter deficiency 11.7
21 urethral villous adenoma 11.7
22 cervical ribs, sprengel anomaly, anal atresia, and urethral obstruction 11.7
23 urethral urothelial papilloma 11.7
24 penile urethral cancer 11.6
25 bulbomembranous urethral cancer 11.6
26 prostatic urethral cancer 11.6
27 infective urethral stricture 11.6
28 duplication of urethra 11.5
29 hypospadias 11.3
30 cervicitis 11.1
31 fowler's syndrome 11.1
32 reactive arthritis 11.1
33 hypospadias 1, x-linked 11.0
34 congenital anomalies of kidney and urinary tract 10.9
35 vacterl association, x-linked 10.9
36 posterior urethra cancer 10.8
37 urethra squamous cell carcinoma 10.8
38 urethra transitional cell carcinoma 10.8
39 anterior urethra cancer 10.8
40 testicular regression syndrome 10.7
41 mucoepithelial dysplasia, hereditary 10.7
42 pigmentary disorder, reticulate, with systemic manifestations 10.7
43 hypospadias 2, x-linked 10.7
44 pelviureteric junction obstruction 10.7
45 urethra clear cell adenocarcinoma 10.6
46 fibroepithelial polyp of urethra 10.6
47 atresia of urethra 10.6
48 urethra inverted papilloma 10.6
49 urethra adenocarcinoma 10.6
50 urethra leiomyoma 10.6

Comorbidity relations with Urethritis via Phenotypic Disease Network (PDN):


Acute Cystitis Bladder Neck Obstruction
Cystitis Prostate Cancer
Prostatic Hypertrophy Trigonitis
Urethral Stricture

Graphical network of the top 20 diseases related to Urethritis:



Diseases related to Urethritis

Symptoms & Phenotypes for Urethritis

Drugs & Therapeutics for Urethritis

Drugs for Urethritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azithromycin Approved Phase 4,Phase 3,Phase 2 83905-01-5 55185 53477736 447043
2
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 564-25-0 54671203
3
Lymecycline Approved Phase 4 992-21-2 5280963
4
Tetracycline Approved, Vet_approved Phase 4 60-54-8 5353990
5 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2
6 Antibiotics, Antitubercular Phase 4,Phase 3
7 Anti-Infective Agents Phase 4,Phase 3,Phase 2
8 Antimalarials Phase 4,Phase 3,Phase 2
9 Antiparasitic Agents Phase 4,Phase 3,Phase 2
10 Antiprotozoal Agents Phase 4,Phase 3,Phase 2
11
Tinidazole Approved, Investigational Phase 2 19387-91-8 5479
12 Alkylating Agents Phase 2
13 Renal Agents Phase 2
14
Ceftriaxone Approved 73384-59-5 5479530 5361919

Interventional clinical trials:


id Name Status NCT ID Phase
1 Time to Eradication of Mycoplasma Genitalium and Chlamydia Trachomatis After Treatment Commenced Unknown status NCT01661985 Phase 4
2 Mycoplasma Genitalium Antibiotic Susceptibility and Treatment (MEGA) Completed NCT00358462 Phase 3
3 NGU: Doxycycline (Plus or Minus Tinidazole) Versus Azithromycin (Plus or Minus Tinidazole) Completed NCT00322465 Phase 2
4 Study to Improve Partner Services for STD Prevention Completed NCT00207467 Phase 2
5 Mecillinam for Treatment of Genital Chlamydia Infection Terminated NCT02083276 Phase 2
6 Antimicrobial Susceptibility Patterns of N. Gonorrhea Isolates in an Era of Quinolone Resistance Completed NCT00692822
7 Chlamydia Trachomatis Immunology and Vaccinology Study Completed NCT01150747
8 Combined Spinal Epidural Urinary Retention Recruiting NCT01597791
9 Chronic Inflammatory Condition of the Male Genital Tract Active, not recruiting NCT01732172

Search NIH Clinical Center for Urethritis

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: urethritis

Genetic Tests for Urethritis

Anatomical Context for Urethritis

MalaCards organs/tissues related to Urethritis:

39
Prostate, Testes, Kidney, Skin, Spinal Cord, Colon, Pancreas

Publications for Urethritis

Articles related to Urethritis:

(show top 50) (show all 2887)
id Title Authors Year
1
Quantitative Real-Time Polymerase Chain Reaction for the Diagnosis of Mycoplasma genitalium Infection in South African Men With and Without Symptoms of Urethritis. ( 27898565 )
2017
2
Anastomotic Urethroplasty for an Obstructing Calculus Within a Bulbar Urethral Diverticulum and Urethral Stricture. ( 27981035 )
2017
3
Role of tubularization of urethral plate in development of urethrocutaneous fistula post hypospadias repair. ( 28479764 )
2017
4
mTUEPA: Trans-Urethral Monopolar Enucleation of Prostatic Adenoma. Preliminary Report. ( 28087281 )
2017
5
The Prostate in Female? Clear Cell Adenocarcinoma in a Female Urethral Diverticulum. ( 27789300 )
2017
6
Genital lichen sclerosus developing around 'ectopic' urethral orifices supports the role of occlusion and urine in its pathogenesis. ( 28081682 )
2017
7
Clinical Characteristics of Herpes Simplex Virus Urethritis Compared With Chlamydial Urethritis Among Men. ( 28079748 )
2017
8
Cost-effective Strategies for the Management and Treatment of Urethral Stricture Disease. ( 27908365 )
2017
9
Re: Outpatient Ultrasound Urethrogram for Assessment of Anterior Urethral Stricture: Early Experience. ( 27979534 )
2017
10
Management of Herpetic Urethritis and Female Partners of Men With Nongonococcal Urethritis. ( 28079750 )
2017
11
Should Female Partners of Men With Non-Gonococcal Urethritis, Negative for Chlamydia trachomatis and Mycoplasma genitalium, Be Informed and Treated? Clinical Outcomes From a Partner Study of Heterosexual Men With NGU. ( 28079749 )
2017
12
Definition of Successful Treatment and Optimal Follow-up after Urethral Reconstruction for Urethral Stricture Disease. ( 27908363 )
2017
13
Successful outcome of macrolide-resistant Mycoplasma genitalium urethritis after spectinomycin treatment: a case report. ( 27707988 )
2017
14
Posterior urethral valves (PUV) in pediatric practice - Promoting methods to understand how to diagnose and incise (PUV). ( 26921022 )
2016
15
Symptomatic urethritis should be confirmed by microscopy. ( 27794144 )
2016
16
Female Urethral Diverticulum: Presentation, Diagnosis, and Predictors of Outcomes After Surgery. ( 27636213 )
2016
17
2016 European guideline on the management of non-gonococcal urethritis. ( 27147267 )
2016
18
High-pressure balloon dilation for male anterior urethral stricture: single-center experience. ( 27604864 )
2016
19
Novel Concept and Method of Endoscopic Urethral Stricture Treatment Using Liquid Buccal Mucosal Graft. ( 27177425 )
2016
20
Angiomyomatous Leiomyoma of a Female Urethral Meatus Recurrence After Seven Years of the Resection: A Case Report. ( 27656416 )
2016
21
Acute Urinary Retention in a Female Following Bladder Tumor Resection Due To a Stone in a Urethral Diverticulum. ( 27085569 )
2016
22
Outcomes and Prognostic Factors of Primary Urethral Cancer. ( 27720774 )
2016
23
Comparative Influence of Imidafenacin and Oxybutynin on Voiding Function in Rats with Functional Urethral Obstruction. ( 26979753 )
2016
24
Female urethral stricture: a contemporary series. ( 27704202 )
2016
25
Vesicostomy and Colostomy in a Premature Neonate With Posterior Urethral Valves, Bilateral Dysplastic Kidneys, and High Imperforate Anus: The Challenge of Stoma Placement. ( 27015939 )
2016
26
Multicenter Analysis of Urinary Urgency and Urge Incontinence in Patients with Anterior Urethral Stricture Disease: Before and after Urethroplasty. ( 27521692 )
2016
27
Early removal of urinary catheter after excision and primary anastomosis in anterior urethral stricture. ( 27274892 )
2016
28
The application of CT voiding urethrography in the evaluation of urethral stricture associated with fistula: a preliminary report. ( 27146077 )
2016
29
Male non-gonococcal urethritis: From microbiological etiologies to demographic and clinical features. ( 26845624 )
2016
30
Predictors of outcome for urethral injection of botulinum toxin to treat detrusor sphincter dyssynergia in men with spinal cord injury. ( 27256824 )
2016
31
Use of an Absorbable Urethral Stent for the Management of a Urethral Stricture in a Stallion. ( 27558926 )
2016
32
Characteristics Associated With Urethral and Rectal Gonorrhea and Chlamydia Diagnoses in a US National Sample of Gay and Bisexual Men: Results From the One Thousand Strong Panel. ( 26859803 )
2016
33
Outpatient Ultrasound Urethrogram for Assessment of Anterior Urethral Stricture: Early Experience. ( 26993351 )
2016
34
Diversity of patient profile, urethral stricture, and other disease manifestations in a cohort of adult men with lichen sclerosus. ( 27195319 )
2016
35
Acute Urethritis and Balonoposthitis Associated to Neisseria elongata. ( 27832027 )
2016
36
Urethral Diverticulum in Women: Retrospective Case Series. ( 26924907 )
2016
37
Urethral Stricture Disease: Challenges and Ongoing Controversies. ( 27051419 )
2016
38
Non-gonococcal urethritis. ( 27107783 )
2016
39
Vaginal-sparing ventral buccal mucosal graft urethroplasty for female urethral stricture: A novel modification of surgical technique. ( 27437540 )
2016
40
Contemporary Management of Primary Distal Urethral Cancer. ( 27717435 )
2016
41
Penile Circular Fasciocutaneous (McAninch) Flap as an Option for Complex Anterior Urethral Stricture in Case of Non-Viable Buccal Mucosal Graft. ( 27630900 )
2016
42
Cultural background, non-therapeutic circumcision and the risk of meatal stenosis and other urethral stricture disease: Two nationwide register-based cohort studies in Denmark 1977-2013. ( 28017691 )
2016
43
Anterior Urethral Valve: A Rare But an Important Cause of Infravesical Urinary Tract Obstruction. ( 27231492 )
2016
44
Lateral-based Anterior Vaginal Wall Flap in the Treatment of Female Urethral Stricture: Efficacy and Safety. ( 27692474 )
2016
45
Long-term outcomes after the excision of horseshoe urethral diverticulum. ( 26670574 )
2016
46
Re: Practice Patterns in the Treatment of Urethral Stricture among American Urologists: A Paradigm Change? ( 26887720 )
2016
47
Buccal mucosal graft urethroplasty for proximal bulbar urethral stricture: A revisit of the surgical technique and analysis of eleven consecutive cases. ( 27833245 )
2016
48
Incomplete Urethral Duplication Associated with a Dermoid Cyst in a Dog with Urinary Obstruction. ( 27890404 )
2016
49
Outcome of Antenatally Presenting Posterior Urethral Valves (PUV) in Children. ( 28031548 )
2016
50
Results of a Two-stage Technique for Treatment of Proximal Hypospadias with Severe Curvature: Creation of a Urethral Plate Using a Vascularized Preputial Island Flap. ( 27085564 )
2016

Variations for Urethritis

Expression for Urethritis

Search GEO for disease gene expression data for Urethritis.

Pathways for Urethritis

Pathways related to Urethritis according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.19 CD40LG CD79A

GO Terms for Urethritis

Cellular components related to Urethritis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 membrane raft GO:0045121 8.8 CD79A HSPD1 TLR6

Biological processes related to Urethritis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.32 HSPD1 TLR6
2 B cell activation GO:0042113 9.26 CD79A HSPD1
3 positive regulation of interleukin-12 production GO:0032735 9.16 CD40LG HSPD1
4 positive regulation of interleukin-10 production GO:0032733 8.96 CD40LG HSPD1
5 B cell proliferation GO:0042100 8.8 CD40LG CD79A HSPD1

Sources for Urethritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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