MCID: URT001
MIFTS: 62

Urethritis malady

Nephrological diseases category

Summaries for Urethritis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Urethritis is inflammation of the urethra. The most common symptom is painful or difficult urination. more...

MalaCards: Urethritis, also known as nongonococcal urethritis, is related to urethral stricture and urethral syndrome. An important gene associated with Urethritis is UBR1 (ubiquitin protein ligase E3 component n-recognin 1), and among its related pathways are Renin-angiotensin system and Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics. The compounds captopril and aliskiren have been mentioned in the context of this disorder. Affiliated tissues include prostate, testes and kidney, and related mouse phenotypes are adipose tissue and mortality/aging.

Aliases & Classifications for Urethritis

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological diseases


Aliases & Descriptions:

urethritis 8 10
nongonococcal urethritis 8 44
nonspecific urethritis 8 60
non-gonococcal urethritis 8
urethritis, unspecified 8
urethritis unspecified 8


External Ids:

Disease Ontology8 DOID:1343
NCIt39 C26904
MeSH34 D014526
ICD9CM27 597.80
ICD1025 N34.1, N37.0

Related Diseases for Urethritis

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17GeneCards, 18GeneDecks
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Diseases related to Urethritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 287)
idRelated DiseaseScoreTop Affiliating Genes
1urethral stricture31.7KLK3
2urethral syndrome31.4KLK4, BCKDHA
3prostatitis31.1KLK3
4urinary tract obstruction30.5ACE
5vesicoureteral reflux30.5AGT, AGTR1
6adenoma30.4KLK4
7ureterocele30.3CYS1
8urethral intrinsic sphincter deficiency30.2PURA
9hypertension30.1TGFB1, ACE2, AGT, AGTR1, ACE
10anuria29.9ACE
11oligohydramnios29.6ACE
12diabetes mellitus29.6ACE, PLIN1, AGT, AGTR1, TGFB1
13urethral obstruction11.0
14urethral diverticulum11.0
15hypospadias10.7
16urethral calculus10.7
17cervicitis10.6
18adenocarcinoma10.5
19vaginitis10.5
20cystitis10.4
21imperforate anus10.4
22detrusor sphincter dyssynergia10.3
23gonorrhea10.3
24prostatic urethral cancer10.3
25lymphogranuloma venereum10.3
26arthritis10.3
27prostate cancer10.3
28clear cell adenocarcinoma10.3
29transitional cell carcinoma10.3
30nephrogenic adenoma10.2
31neurogenic bladder10.2
32balanitis xerotica obliterans10.2
33reactive arthritis10.2
34balanitis10.2
35male urethral cancer10.2
36prostatic hypertrophy10.2
37bladder neck obstruction10.2
38rhinosporidiosis10.2
39female urethral cancer10.2
40impotence10.2
41pyelonephritis10.2
42prostate calculus10.2
43urethral false passage10.2
44female stress incontinence10.2
45down syndrome10.2
46squamous cell carcinoma10.2
47urethra cancer10.2
48cervical ribs, sprengel anomaly, anal atresia, and urethral obstruction10.2
49posterior urethral valve10.2
50pyuria10.1

Graphical network of the top 20 diseases related to Urethritis:



Diseases related to urethritis

Clinical Features for Urethritis

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Drugs & Therapeutics for Urethritis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Urethritis

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Anatomical Context for Urethritis

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32MalaCards
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MalaCards organs/tissues related to Urethritis:

32
Prostate, Testes, Kidney, Skin, Spinal cord, Colon, Pancreas, Small intestine, Bone, Smooth muscle, Heart, T cells, Cervix, Ovary, Lung, Skeletal muscle, Brain, Endothelial

Animal Models for Urethritis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Urethritis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537510.4TGFB1, ACE, PLIN1, AGT, UBR1
2MP:001076810.4ACE, ACE2, TGFB1, CYS1, AGT, AGTR1
3MP:000537610.3TGFB1, ACE, KLK4, PURA, UBR1, AGTR1
4MP:000537810.3CIAPIN1, TGFB1, ACE, PLIN1, CYS1, AGT
5MP:000537010.3CIAPIN1, AGT, CYS1, PLIN1, ACE, TGFB1
6MP:000536710.1AGTR1, AGT, CYS1, ACE, ACE2, TGFB1

Publications for Urethritis

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50PubMed
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Articles related to Urethritis:

(show top 50)    (show all 2525)
idTitleAuthorsYear
1
Urethral diverticulum calculi in a male: a case report. (23401841)
2013
2
Impact of asymptomatic prostatitis on re-operations due to urethral stricture or bladder neck contracture developed after TUR-P. (22252218)
2012
3
Posterior urethral valves and adult sexual function. (22448709)
2012
4
Fournier's Gangrene in a Heterosexual Man: A Complication of Neisseria meningitidis Urethritis. (23304623)
2012
5
Triamcinolone injection following internal urethrotomy for treatment of urethral stricture. (21656472)
2011
6
Evaluation of anterior urethral stricture using thick slab SSFSE MR urethrography. (20942737)
2010
7
Distribution and significance of I+1-adrenoceptor subtypes in patients with chronic prostatitis in prostate, bladder detrusor and posterior urethral tissue]. (21223784)
2010
8
Is tubularization of the mobilized urethral plate a better alternative to tubularization of an incised urethral plate for hypospadias repair? (19096854)
2009
9
Congenital urethral hypoplasia with urethral fistula without imperforate anus: report of two cases. (19858662)
2008
10
Internal urethrotomy combined with antegrade flexible cystoscopy for management of obliterative urethral stricture. (18825626)
2008
11
Imaging of female urethral diverticulum: an update. (19001648)
2008
12
Quantitative detection of Ureaplasma parvum (biovar 1) and Ureaplasma urealyticum (biovar 2) in urine specimens from men with and without urethritis by real-time polymerase chain reaction. (17522569)
2007
13
Nongonococcal urethritis: a few answers but mostly questions. (16388479)
2006
14
Mycoplasma hominis and Ureaplasma urealyticum infections in male urethritis and its complications. (17357320)
2006
15
Posterior urethral valve: Outcome of antenatal intervention. (17010011)
2006
16
Asymptomatic Chlamydia trachomatis-negative non-gonococcal urethritis. (15899091)
2005
17
Re: Lichen sclerosus of the male genitalia and urethral stricture diseases. (16123579)
2005
18
Prostatitis, interstitial cystitis, chronic pelvic pain, and urethral syndrome share a common pathophysiology: lower urinary dysfunctional epithelium and potassium recycling. (14665339)
2003
19
Urethral reconstruction of strictures resulting from treatment of benign prostatic hypertrophy and prostate cancer. (12371233)
2002
20
The detection of Chlamydia trachomatis by DNA amplification methods in urine samples from men with urethritis. (11779369)
2001
21
Increased urinary transforming growth factor-beta(1) excretion in children with posterior urethral valves. (10925100)
2000
22
Functional urethral obstruction in 3 dogs: clinical and urethral pressure profile findings. (10668816)
2000
23
Predictive factors of fetal urethral obstruction: a multivariate analysis. (10782006)
2000
24
A case of female large urethral diverticulum treated by electrofulguration. (10609545)
1999
25
Urethritis. Diagnosis of nongonococcal urethritis. (9891671)
1998
26
Posterior urethral valves: inaccuracy of prenatal diagnosis. (9708443)
1998
27
The management of unilateral poorly functioning kidneys in patients with posterior urethral valves. (9258129)
1997
28
Standardization of terminology of lower urinary tract function: pressure-flow studies of voiding, urethral resistance, and urethral obstruction. International Continence Society Subcommittee on Standardization of Terminology of Pressure-Flow Studies. (9021786)
1997
29
Impotence following pelvic fracture urethral injury: incidence, aetiology and management. (7850299)
1995
30
Analysis of factors contributing to success or failure of 1-stage urethroplasty for urethral stricture disease. (8126813)
1994
31
Transitional cell carcinoma in a urethral diverticulum. (1586346)
1992
32
Prolapsing congenital polyp of posterior urethra and urethral duplication associated with imperforate anus. (1466105)
1992
33
The mysterious "urethral syndrome". (1859947)
1991
34
Azithromycin vs doxycycline in the treatment of non-gonococcal urethritis. (1655056)
1991
35
Clinical and microbiologic features of urethritis in men in Toulouse, France. (1907404)
1991
36
Endoscopic management of urethral stricture: "cut to the light" procedure. (2305533)
1990
37
Detecting Chlamydia trachomatis in men with urethritis: serology v isolation in cell culture. (2668155)
1989
38
Teflon injection in female stress incontinence. Effect on urethral pressure profile and flow rate. (3408866)
1988
39
Antibacterial therapy for women with abacterial cystitis (urethral syndrome) (6346159)
1983
40
Unsuspected urethral stricture presenting as acute water intoxication. (6887381)
1983
41
Large caliber urethral false passage after catheterization: a case report. (7143610)
1982
42
Ultrasonic characteristics of posterior urethral valves. (7122871)
1982
43
Urethro-caverno-cutaneous fistula with distal urethral stricture and aberrant voiding into corpora cavernosa. (7394989)
1980
44
Posterior urethral valves. (588718)
1977
45
Urethral diverticulum: diagnosis by ultrasound. (403810)
1977
46
The effect of a 6FG urethral catheter on urinary flow in benign prostatic hypertrophy. (61185)
1976
47
Detrusor and urethral dysfunction in prostatic hypertrophy. (64268)
1976
48
Repair of urethral diverticulum or vesicovaginal fistula by vaginal flap technic. (817241)
1976
49
GONOCOCCAL URETHRAL STRICTURE AND HYPERTENSION. EXPERIENCE IN UGANDA. (14210486)
1964
50
Urethral obstruction in childhood; the use of urethrography in diagnosis. (13269355)
1955

Genetic Variations for Urethritis

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Expression for genes affiliated with Urethritis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Urethritis

Search GEO for disease gene expression data for Urethritis.

Pathways for genes affiliated with Urethritis

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29KEGG, 53Reactome, 49PharmGKB, 37NCBI BioSystems Database
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Pathways related to Urethritis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.5ACE2
2
Hide members
10.4TGFB1, ACE2
3
Hide members
10.4ACE2, ACE, AGT

Compounds for genes affiliated with Urethritis

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44Novoseek, 28IUPHAR, 49PharmGKB, 59Tocris Bioscience, 11DrugBank, 24HMDB
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Compounds related to Urethritis according to GeneCards/GeneDecks:

(show all 48)
idCompoundScoreTop Affiliating Genes
1captopril44 28 49 59 1114.9ACE2
2aliskiren44 1111.9ACE, AGT, AGTR1
3benazepril44 1111.9AGTR1, AGT, ACE, TGFB1
4saralasin4410.9AGTR1, AGT, ACE
5eprosartan44 28 1112.9ACE, AGT, AGTR1
6perindopril44 49 1112.9AGTR1, AGT, ACE, TGFB1
7candesartan44 28 1112.9TGFB1, ACE, AGT, AGTR1, KLK3
8angiotensin ii28 2411.9AGTR1, ACE, ACE2
9lisinopril44 11 2412.9AGTR1, AGT, ACE, ACE2
10pd12331944 2811.9ACE, AGT, AGTR1
11ramipril44 1111.9TGFB1, ACE2, ACE, AGTR1
12olmesartan44 28 1112.9AGTR1, AGT, ACE
13ang ii4410.8AGTR1, AGT, ACE, TGFB1
14eplerenone44 59 28 1113.8AGTR1, ACE, ACE2
15chymostatin4410.8ACE, AGT, AGTR1
16atenolol44 28 49 11 2414.8ACE, AGT, AGTR1
17enalaprilat4410.8ACE2, ACE, AGT
18valsartan44 59 28 1113.8AGTR1, AGT, ACE
19losartan44 49 28 1113.8AGTR1, AGT, ACE, TGFB1
20telmisartan44 28 1112.8ACE, AGT, AGTR1
21temocaprilat4410.8AGTR1, ACE
22doxazosin44 1111.8ACE, AGTR1, KLK3
23irbesartan44 28 49 1113.8AGTR1, AGT, ACE
24benazepril hydrochloride5910.8ACE, ACE2
25moexipril hydrochloride5910.8ACE, ACE2
26perindopril erbumine5910.8ACE, ACE2
27hydrochlorothiazide44 49 28 11 2414.8AGTR1, AGT, ACE
28diltiazem44 28 1112.8ACE, AGT, AGTR1
29enalapril44 49 1112.8AGTR1, AGT, ACE
30spironolactone49 44 59 28 1114.8ACE, AGTR1, KLK3
31amlodipine44 49 11 2413.8ACE, AGT, AGTR1
32remikiren44 1111.8ACE, AGT
33nifedipine44 49 28 1113.7AGTR1, AGT, ACE, TGFB1
34cv 119744410.7AGT, AGTR1
35moexipril44 1111.7ACE2, ACE
36cgp42112a4410.7AGTR1, AGT
37lacidipine4410.7ACE, AGTR1
38deoxyribonucleic acid4410.7AGT, AGTR1, KLK3
39trandolapril44 1111.7ACE, AGTR1
40aspirin44 49 28 2413.6KLK3, AGTR1, ACE, TGFB1
41cilazapril44 1111.6ACE, AGTR1
42bradykinin59 28 2412.6ACE, AGTR1
43fosinopril44 1111.6AGTR1, ACE
44quinapril44 1111.5ACE, AGTR1
45norepinephrine44 11 2412.5PLIN1
46serine4410.4TGFB1, PLIN1, CLPP, AGT, AGTR1, KLK3
47sele4410.4ACE, AGT
48cholesterol44 28 11 2413.1AGTR1, AGT, PLIN1, ACE, ACE2

GO Terms for genes affiliated with Urethritis

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16Gene Ontology
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Biological processes related to Urethritis according to GeneCards/GeneDecks:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1regulation of systemic arterial blood pressure by renin-angiotensinGO:00308110.8AGTR1, ACE, ACE2
2positive regulation of cellular protein metabolic processGO:03227010.8AGTR1, AGT, TGFB1
3regulation of vasoconstrictionGO:01922910.8ACE2, ACE, AGT, AGTR1
4regulation of vasodilationGO:04231210.8ACE2, ACE, AGTR1
5angiotensin maturationGO:00200310.7AGT, ACE, ACE2
6positive regulation of NAD(P)H oxidase activityGO:03386410.7AGTR1, AGT
7positive regulation of reactive oxygen species metabolic processGO:200037910.7ACE2, AGT, AGTR1
8mononuclear cell proliferationGO:03294310.7ACE, TGFB1
9kidney developmentGO:00182210.7AGTR1, AGT, CYS1, ACE
10regulation of renal output by angiotensinGO:00201910.7AGT, ACE
11angiotensin-mediated drinking behaviorGO:00305110.7AGT, ACE2
12regulation of blood vessel size by renin-angiotensinGO:00203410.7AGTR1, AGT
13angiotensin catabolic process in bloodGO:00200510.7ACE, ACE2
14renin-angiotensin regulation of aldosterone productionGO:00201810.7AGT, AGTR1
15regulation of renal sodium excretionGO:03581310.6AGT, AGTR1
16positive regulation of superoxide anion generationGO:03293010.6AGT, TGFB1
17positive regulation of cholesterol esterificationGO:01087310.6AGTR1, AGT
18proteolysisGO:00650810.5ACE2, ACE, CLPP, KLK3, KLK4
19low-density lipoprotein particle remodelingGO:03437410.5AGTR1, AGT
20negative regulation of mitotic cell cycleGO:04593010.4TGFB1, NKX3-1
21regulation of cell proliferationGO:04212710.3ACE2, AGT, AGTR1
22positive regulation of macrophage derived foam cell differentiationGO:01074410.2AGT, AGTR1

Molecular functions related to Urethritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1bradykinin receptor bindingGO:03171110.5AGTR1, ACE
2acetyltransferase activator activityGO:01069810.5AGTR1, AGT
3carboxypeptidase activityGO:00418010.4ACE, ACE2
4peptidyl-dipeptidase activityGO:00824110.1ACE, ACE2
5protein bindingGO:00551510.1NKX3-1, PRUNE, CIAPIN1, PURA, KLK3, AGTR1

Products for genes affiliated with Urethritis

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  • Antibodies
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Sources for Urethritis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet