MCID: URT001
MIFTS: 54

Urethritis malady

Nephrological diseases category
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Summaries for Urethritis

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65Wikipedia, 33MalaCards
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Wikipedia:65 Urethritis is inflammation of the urethra. The most common symptom is painful or difficult urination. more...

MalaCards: Urethritis, also known as nongonococcal urethritis, is related to prostatitis and arthritis. An important gene associated with Urethritis is HSPD1 (heat shock 60kDa protein 1 (chaperonin)), and among its related pathways are Selected targets of GCR alpha and Legionellosis. The compounds bifidobacterium and tuberculin have been mentioned in the context of this disorder. Affiliated tissues include prostate, testes and kidney.

Aliases & Classifications for Urethritis

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Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 35MeSH, 58SNOMED-CT, 40NCIt, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological diseases


Aliases & Descriptions:

urethritis 8 10
nongonococcal urethritis 8 45
nonspecific urethritis 8 62
non-gonococcal urethritis 8
urethritis, unspecified 8
urethritis unspecified 8


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Disease Ontology8 DOID:1343
MeSH35 D014526
NCIt40 C26904
ICD9CM27 597.80
ICD1025 N34.1, N37.0

Related Diseases for Urethritis

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Urethritis:



Diseases related to urethritis

Symptoms for Urethritis

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Drugs & Therapeutics for Urethritis

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Urethritis

Search NIH Clinical Center for Urethritis

Genetic Tests for Urethritis

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Anatomical Context for Urethritis

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33MalaCards
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MalaCards organs/tissues related to Urethritis:

33
Prostate, Testes, Kidney, Skin, Spinal cord, Colon, Pancreas, Bone, Small intestine, T cells, Smooth muscle, Heart, Skeletal muscle, Endothelial, Lung, Ovary, Brain, Cervix

Animal Models for Urethritis or affiliated genes

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Publications for Urethritis

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52PubMed
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Articles related to Urethritis:

(show top 50)    (show all 2499)
idTitleAuthorsYear
1
Renal Parenchymal Area and Risk of ESRD in Boys with Posterior Urethral Valves. (24311709)
2013
2
First experiences with the Spannera8c temporary prostatic stent for prostatic urethral obstruction. (23886821)
2013
3
Posterior urethral valves: determinants of outcome in a developing country. (23331631)
2013
4
Robotic-Assisted Urethrolysis for Urethral Obstruction After Retropubic Bladder Neck Suspension-A Case Series Report. (24074259)
2013
5
Urethral strictures following urethral plate and proximal urethral elevation during proximal TIP hypospadias repair. (23707201)
2013
6
Commentary to 'Role of urethral bulking agents in epispadias/exstrophy complex patients' (24183655)
2013
7
Urethral diverticulum calculi in a male: a case report. (23401841)
2013
8
Re: Preputial/penile skin flap, as a dorsal onlay or tubularized flap: a versatile substitute for complex anterior urethral stricture. (23931204)
2013
9
Therapeutic outcome and quality of life between urethral and detrusor botulinum toxin treatment for patients with spinal cord lesions and detrusor sphincter dyssynergia. (24073977)
2013
10
PCR for diagnosis of male Trichomonas vaginalis infection with chronic prostatitis and urethritis. (22711929)
2012
11
Development of a porcine animal model for urethral stricture repair using autologous urothelial cells. (21398188)
2012
12
The clinical spectrum of the presenting signs and symptoms of anterior urethral stricture: detailed analysis of a single institutional cohort. (22446349)
2012
13
Coccygeal epidural with local anesthetic for catheterization and pain management in the treatment of feline urethral obstruction. (21288294)
2011
14
In vitro activity of azithromycin against Mycoplasma genitalium and its efficacy in the treatment of male Mycoplasma genitalium-positive nongonococcal urethritis. (21710162)
2011
15
Re: chlorhexidine rinse for prevention of urethritis in men linked to oral sex. (22088634)
2011
16
Management of anterior urethral stricture: an evidence-based approach. (20827208)
2010
17
Fluoroscopic stent placement for the relief of malignant urethral obstruction in a cat. (21091459)
2010
18
A rare cause of ascites in a newborn: posterior urethral valve. (20158664)
2010
19
The new pattern of urethral stricture disease in Lagos, Nigeria. (19606199)
2009
20
Bulbar urethral ligation for managing persistent urinary incontinence in young men with myelomeningocele. (19245443)
2009
21
Posterior urethral valves are often associated with cryptorchidism and inguinal hernias. (18554641)
2008
22
Staged pendulous-prostatic anastomotic urethroplasty followed by reconstruction of the anterior urethra: an effective treatment for long-segment bulbar and membranous urethral stricture. (16904816)
2007
23
A comparison of clinical features between chlamydial and non-chlamydial urethritis in men negative for gonococcal infection who attended a urological outpatient clinic in Japan. (17211572)
2007
24
Management of urethral hemangiomas associated with Klippel-Trenaunay-Weber syndrome by endoscopic sclerotherapy. (17645615)
2007
25
Renal transplantation in children with posterior urethral valves. (16491414)
2006
26
Urethral obstruction due to lobular mesonephric hyperplasia of the vagina--a case report. (16758778)
2005
27
Suprapubic electroresection of prostate in three patients with benign prostatic hyperplasia and previous surgery for long urethral stricture. (15833539)
2005
28
Asymptomatic Chlamydia trachomatis-negative non-gonococcal urethritis. (15899091)
2005
29
Long-term followup of bilateral high (sober) urinary diversion in patients with posterior urethral valves and its effect on bladder function. (15821568)
2005
30
Meningococcal urethritis in a heterosexual man. (15278728)
2004
31
Transvaginal sonographic findings in diagnosis and treatment of urethral stricture. (14682433)
2003
32
Prevalence of asymptomatic chlamydial urethritis in military recruits in the Celje region, Slovenia. (14624741)
2003
33
Posterior urethral valves: prognostic factors. (12699486)
2003
34
Risk behaviours associated with urethritis and genital ulcer disease in prison inmates, Sindh, Pakistan. (15568455)
2002
35
Increased urinary transforming growth factor-beta(1) excretion in children with posterior urethral valves. (10925100)
2000
36
Equal symptomatic outcome after antibacterial treatment of acute lower urinary tract infection and the acute urethral syndrome in adult women. (10555247)
1999
37
Urethritis and cervicitis. (10330757)
1999
38
Urethral diverticulum and urethrocutaneous fistula presenting as a mass over the medical thigh. (9722775)
1998
39
Congenital posterior urethral obstruction: the historical perspective. (9156879)
1997
40
Immunity to reinfection and immunization of male guinea pigs against urethral infection with the agent of guinea pig inclusion conjunctivitis. (8919742)
1996
41
Pseudo-haematuria caused by utero-urethral fistula from Mayer-Rokitansky-KA1ster-Hauser syndrome. (7788277)
1995
42
Prevention of urethral stricture recurrence using clean intermittent self-catheterization. (8032838)
1994
43
Mercapto-acetyltriglycine (MAG 3) renography and indirect radionuclide cystography in posterior urethral valves. (7827852)
1994
44
Female urethral cancer--an overview. (3429167)
1987
45
Urinary tract infections and the urethral syndrome in adult women: pathogenesis, diagnosis, and therapy. (3902456)
1985
46
The ultrastructure of human male urethral stricture. (1222353)
1975
47
Carcinoma of Skene's gland associated with urethral diverticulum: a case report. (4369830)
1974
48
Congenital urethral membranes causing urethral obstruction. (4810775)
1974
49
Urethral stricture. (4691433)
1973
50
Case of Vesico-urethral Calculus. (19983442)
1923

Variations for Urethritis

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Expression for genes affiliated with Urethritis

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Urethritis

Search GEO for disease gene expression data for Urethritis.

Pathways for genes affiliated with Urethritis

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50PathCards, 12EMD Millipore, 30KEGG, 60Thomson Reuters, 55Reactome
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Pathways related to Urethritis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5IL8, HSPD1
29.5IL8, HSPD1
3
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
9.4IL8, DEFB4A
4
Show member pathways
9.2DEFA5, DEFB4A

Compounds for genes affiliated with Urethritis

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Sources:
45Novoseek, 24HMDB, 11DrugBank, 29IUPHAR, 51PharmGKB, 61Tocris Bioscience
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Compounds related to Urethritis according to GeneCards/GeneDecks:

(show top 50)    (show all 61)
idCompoundScoreTop Affiliating Genes
1bifidobacterium4510.0HSPD1, LTF
2tuberculin459.9CD79A, HSPD1
3hypothiocyanite45 2410.9LTF, CD79A
4lactulose459.9CD79A, LTF
5pneumococcal459.9CD79A, LTF
6thiocyanate45 2410.9CD79A, LTF
7toxin-1459.8IL8, HSPD1
8pmma459.8LTF, CD79A
9fluconazole45 1110.8LTF, CD79A
10hcec459.8IL8, DEFB4A
11citric acid45 29 24 1112.7LTF, HSPD1
12azithromycin45 1110.7CD79A, IL8
13lipoteichoic acid459.7IL8, DEFB4A
14budesonide45 51 1111.6LTF, IL8
15protamine459.5LTF, IL8
16doxycycline45 1110.5LTF, CD79A, HSPD1
17sulfasalazine29 45 51 1112.5CD79A, IL8
18flagellin45 2910.5DEFB4A, HSPD1, IL8
19anti-fungal459.5DEFB4A, CD79A, LTF
20citrate459.5LTF, CD79A, HSPD1
21salbutamol45 51 29 24 1113.5IL8, CD79A
22polymyxin b459.5HSPD1, IL8, LTF
23indomethacin45 29 61 1112.4LTF, CD79A, HSPD1
24polysaccharide459.4HSPD1, CD79A, LTF
25rantes459.4DEFB4A, HSPD1, IL8
26n-formylmethionyl-leucylphenylalanine459.4LTF, IL8
27fibrinogen459.4LTF, CD79A, HSPD1
28pd 98,059459.3DEFB4A, HSPD1, IL8
29clarithromycin45 1110.3IL8, CD79A, LTF
30methacholine45 51 1111.3LTF, CD79A, IL8
31neopterin459.3LTF, CD79A, IL8
32hyaluronic acid45 2410.3LTF, CD79A, IL8
33mannose459.2DEFB4A, HSPD1, CD79A, LTF
34peptidoglycan45 2910.1IL8, DEFB4A
35paraffin459.1DEFB4A, HSPD1, CD79A, LTF
36hbd2459.1IL8, DEFA5, DEFB4A
37endotoxin459.1LTF, IL8, HSPD1, DEFB4A
38retinoic acid45 2410.0DEFB4A, HSPD1, CD79A, LTF
39pge2459.0LTF, CD79A, IL8
40lactate459.0HSPD1, IL8, CD79A
41n acetylcysteine458.9HSPD1, IL8, CD79A, LTF
42superoxide45 249.9LTF, IL8, HSPD1
43cyclosporin a45 29 6110.9LTF, CD79A, IL8, HSPD1
44h2o2458.9HSPD1, IL8, CD79A, LTF
45histamine45 29 2410.9DEFB4A, IL8, CD79A, LTF
46heparin45 29 24 1111.9DEFB4A, IL8, CD79A, LTF
47vegf458.9HSPD1, IL8, CD79A, LTF
48estrogen458.6DEFB4A, HSPD1, PHB2, CD79A, LTF
49dexamethasone45 51 29 1111.5LTF, CD79A, IL8, HSPD1, DEFB4A
50cysteine458.5DEFB4A, HSPD1, IL8, CD79A, LTF

GO Terms for genes affiliated with Urethritis

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16Gene Ontology
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Cellular components related to Urethritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granuleGO:0301419.3LTF, HSPD1
2Golgi lumenGO:0057969.2DEFA5, DEFB4A
3extracellular spaceGO:0056158.2LTF, IL8, HSPD1, DEFA5
4extracellular regionGO:0055768.1DEFB4A, DEFA5, IL8, LTF

Biological processes related to Urethritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1B cell activationGO:0421139.5CD79A, HSPD1
2chemotaxisGO:0069359.4IL8, DEFB4A
3B cell proliferationGO:0421009.3CD79A, HSPD1
4antibacterial humoral responseGO:0197319.2LTF, DEFA5

Products for genes affiliated with Urethritis

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  • Antibodies
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Sources for Urethritis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet