MCID: URT001
MIFTS: 44

Urethritis

Categories: Nephrological diseases

Aliases & Classifications for Urethritis

MalaCards integrated aliases for Urethritis:

Name: Urethritis 12 41 14 69
Non-Gonococcal Urethritis 12 69
Nongonococcal Urethritis 12 51
Nonspecific Urethritis 69

Classifications:



External Ids:

Disease Ontology 12 DOID:1343
ICD9CM 34 597.80
MeSH 41 D014526
NCIt 46 C26904

Summaries for Urethritis

MalaCards based summary : Urethritis, also known as non-gonococcal urethritis, is related to urethral syndrome and reactive arthritis. An important gene associated with Urethritis is DEFB4A (Defensin Beta 4A), and among its related pathways/superpathways is Primary immunodeficiency. The drugs Azithromycin and Doxycycline have been mentioned in the context of this disorder. Affiliated tissues include prostate, testes and kidney.

Wikipedia : 72 Urethritis is inflammation of the urethra. The most common symptom is painful or difficult urination. It... more...

Related Diseases for Urethritis

Diseases related to Urethritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 439)
# Related Disease Score Top Affiliating Genes
1 urethral syndrome 32.9 CD40LG CD79A MRAP MT-TG PHB2
2 reactive arthritis 31.7 CD79A HSPD1
3 cervicitis 31.4 CD79A DEFB4A HSPD1 MRAP MT-TG
4 chlamydia 30.8 CD40LG CD79A HSPD1
5 balanitis 30.7 MRAP PHB2
6 rhinosporidiosis 30.3 CD40LG CD79A
7 bacteriuria 30.0 CD40LG CD79A
8 pleuropneumonia 29.8 CD40LG CD79A
9 primary syphilis 29.6 CD40LG EXTL3
10 amebiasis 29.6 CD40LG CD79A
11 inclusion conjunctivitis 29.5 CD40LG CD79A
12 pyelitis 29.5 CD40LG CD79A
13 trichomoniasis 29.5 CD79A EXTL3
14 pelvic inflammatory disease 29.5 CD40LG HSPD1 TLR6
15 lymphoma, mucosa-associated lymphoid type 29.3 CD40LG CD79A HSPD1
16 syphilis 29.2 CD40LG CD79A EXTL3
17 urethral stricture 12.4
18 posterior urethral valves 12.4
19 urethral diverticulum 12.3
20 urethral cancer 12.2
21 urethral benign neoplasm 12.0
22 urethral calculus 12.0
23 urethral obstruction sequence 12.0
24 female urethral cancer 12.0
25 cervical ribs, sprengel anomaly, anal atresia, and urethral obstruction 12.0
26 urethral gland abscess 12.0
27 male urethral cancer 11.9
28 urethral false passage 11.9
29 urethral intrinsic sphincter deficiency 11.9
30 anterior urethral valve 11.9
31 urethral urothelial papilloma 11.8
32 urethral verrucous carcinoma 11.8
33 urethral villous adenoma 11.8
34 vitiligo, progressive, with mental retardation and urethral duplication 11.7
35 infective urethral stricture 11.7
36 prostatic urethral cancer 11.7
37 penile urethral cancer 11.7
38 bulbomembranous urethral cancer 11.7
39 duplication of urethra 11.6
40 hypospadias 11.5
41 urethra squamous cell carcinoma 11.2
42 fowler's syndrome 11.2
43 atresia of urethra 11.1
44 hypospadias 1, x-linked 11.1
45 vacterl association, x-linked, with or without hydrocephalus 11.0
46 congenital anomalies of kidney and urinary tract 1 11.0
47 urethra transitional cell carcinoma 10.9
48 posterior urethra cancer 10.9
49 anterior urethra cancer 10.9
50 congenital anomalies of kidney and urinary tract 2 10.8

Comorbidity relations with Urethritis via Phenotypic Disease Network (PDN):


Acute Cystitis Bladder Neck Obstruction
Cystitis Prostate Cancer
Prostatic Hypertrophy Trigonitis
Urethral Stricture

Graphical network of the top 20 diseases related to Urethritis:



Diseases related to Urethritis

Symptoms & Phenotypes for Urethritis

Drugs & Therapeutics for Urethritis

Drugs for Urethritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 48)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azithromycin Approved Phase 4,Phase 3,Phase 2 83905-01-5 53477736 447043 55185
2
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 564-25-0 54671203
3
Lymecycline Approved, Investigational Phase 4 992-21-2 5280963
4
Tetracycline Approved, Vet_approved Phase 4 60-54-8 5353990
5 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2
6 Antibiotics, Antitubercular Phase 4,Phase 3
7 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Not Applicable
8 Antimalarials Phase 4,Phase 3,Phase 2,Not Applicable
9 Antiparasitic Agents Phase 4,Phase 3,Phase 2,Not Applicable
10 Antiprotozoal Agents Phase 4,Phase 3,Phase 2,Not Applicable
11
Tinidazole Approved, Investigational Phase 2 19387-91-8 5479
12 Alkylating Agents Phase 2
13 Renal Agents Phase 2,Not Applicable
14 Amdinocillin Pivoxil Phase 2
15
Ceftriaxone Approved 73384-59-5 5479530 5361919
16
Methylprednisolone Approved, Vet_approved Not Applicable 83-43-2 6741
17
Prednisolone Approved, Vet_approved Not Applicable 50-24-8 5755
18
Sulfamethoxazole Approved Not Applicable 723-46-6 5329
19
Trimethoprim Approved, Vet_approved Not Applicable 738-70-5 5578
20 Orange Approved, Nutraceutical Not Applicable
21
Folic Acid Approved, Nutraceutical, Vet_approved Not Applicable 59-30-3 6037
22
leucovorin Approved, Nutraceutical Not Applicable 58-05-9 143 6006
23 Angiotensin-Converting Enzyme Inhibitors Not Applicable
24 Antiemetics Not Applicable
25 Anti-Inflammatory Agents Not Applicable
26 Antineoplastic Agents, Hormonal Not Applicable
27 Autonomic Agents Not Applicable
28 Cytochrome P-450 Enzyme Inhibitors Not Applicable
29 Folic Acid Antagonists Not Applicable
30 Gastrointestinal Agents Not Applicable
31 glucocorticoids Not Applicable
32 HIV Protease Inhibitors Not Applicable
33 Hormone Antagonists Not Applicable
34 Hormones Not Applicable
35 Hormones, Hormone Substitutes, and Hormone Antagonists Not Applicable
36 Immunoglobulin A Not Applicable
37 Methylprednisolone acetate Not Applicable
38 Methylprednisolone Hemisuccinate Not Applicable
39 Neuroprotective Agents Not Applicable
40 Peripheral Nervous System Agents Not Applicable
41 Prednisolone acetate Not Applicable
42 Prednisolone hemisuccinate Not Applicable
43 Prednisolone phosphate Not Applicable
44
protease inhibitors Not Applicable
45 Protective Agents Not Applicable
46 Vitamin B Complex Not Applicable
47 Folate Nutraceutical Not Applicable
48 Vitamin B9 Nutraceutical Not Applicable

Interventional clinical trials:

(show all 15)

# Name Status NCT ID Phase Drugs
1 Time to Eradication of Mycoplasma Genitalium and Chlamydia Trachomatis After Treatment Commenced Unknown status NCT01661985 Phase 4 Azithromycin;Doxycycline;lymecycline
2 Long-term Evaluation on Height and Weight in Patients With MPS II Who Started Treatment at < 6 Years of Age Recruiting NCT02455622 Phase 4 Elaprase for intravenous (IV) infusion
3 Mycoplasma Genitalium Antibiotic Susceptibility and Treatment (MEGA) Completed NCT00358462 Phase 3 Azithromycin;Doxycycline
4 NGU: Doxycycline (Plus or Minus Tinidazole) Versus Azithromycin (Plus or Minus Tinidazole) Completed NCT00322465 Phase 2 Tinidazole;Doxycycline;Azithromycin
5 Study to Improve Partner Services for STD Prevention Completed NCT00207467 Phase 2
6 Trial to Assess the Efficacy of F598 in Preventing an Experimental Urethral Infection With N. Gonorrhoeae in Healthy Males Recruiting NCT03222401 Phase 2 1 mg/kg single infusion of F598;3 mg/kg single infusion of F598;10 mg/kg single infusion of F598
7 Safety, Tolerability, and Efficacy of Etrasimod (APD334) in Patients With Primary Biliary Cholangitis Recruiting NCT03155932 Phase 2 APD334
8 Mecillinam for Treatment of Genital Chlamydia Infection Terminated NCT02083276 Phase 2 Pivmecillinamhydrochlorid
9 Accuracy of Detection Using ENdocuff Optimisation of Mucosal Abnormalities Unknown status NCT02552017 Not Applicable
10 Antimicrobial Susceptibility Patterns of N. Gonorrhea Isolates in an Era of Quinolone Resistance Completed NCT00692822
11 Chlamydia Trachomatis Immunology and Vaccinology Study Completed NCT01150747 ceftriaxone;Azithromycin
12 Therapeutic Evaluation of Steroids in IgA Nephropathy Global Study (TESTING Low Dose Study) Recruiting NCT01560052 Not Applicable methylprednisolone;Placebo
13 A Multicenter, Multinational, Observational Morquio A Registry Study (MARS) Recruiting NCT02294877 Vimizim® (elosulfase alfa)
14 Chronic Inflammatory Condition of the Male Genital Tract Active, not recruiting NCT01732172
15 Combined Spinal Epidural Urinary Retention Terminated NCT01597791

Search NIH Clinical Center for Urethritis

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: urethritis

Genetic Tests for Urethritis

Anatomical Context for Urethritis

MalaCards organs/tissues related to Urethritis:

38
Prostate, Testes, Kidney, Skin, Spinal Cord, Colon, Pancreas

Publications for Urethritis

Articles related to Urethritis:

(show top 50) (show all 2973)
# Title Authors Year
1
GyrA and/or ParC alterations of Haemophilus influenzae strains isolated from the urethra of men with acute urethritis. ( 29138021 )
2018
2
Re: Low Testosterone Levels Result in Decreased Periurethral Vascularity via an Androgen Receptor-Mediated Process: Pilot Study in Urethral Stricture Tissue. ( 29357549 )
2018
3
microRNA expression profiles of scar and normal tissue from patients with posterior urethral stricture caused by pelvic fracture urethral distraction defects. ( 29436608 )
2018
4
Asymptomatic urethral lymphogranuloma venereum: a case report. ( 29350113 )
2018
5
Evaluation of the Microbiological Efficacy of a Single 2-Gram Dose of Extended-Release Azithromycin by Population Pharmacokinetics and Simulation in Japanese Patients with Gonococcal Urethritis. ( 29038284 )
2018
6
Hypoandrogenism is Prevalent in Males with Urethral Stricture Disease and is Associated with Longer Strictures. ( 29378279 )
2018
7
A novel heterozygous GLI2 mutation in a patient with congenital urethral stricture and renal hypoplasia/dysplasia leading to end-stage renal failure. ( 29318530 )
2018
8
Combined prostatic urethral lift and remodeling of the prostate and bladder neck: a modified transurethral approach in the treatment of symptomatic lower urinary tract obstruction. ( 29450732 )
2018
9
Re: Urethral Stricture Outcomes after Artificial Urinary Sphincter Cuff Erosion: Results from a Multicenter Retrospective Analysis. ( 29357550 )
2018
10
Management of long segment anterior urethral stricture (a8Y 8cm) using buccal mucosal (BM) graft and penile skin (PS) flap: outcome and predictors of failure. ( 29211404 )
2018
11
AT<sub>1</sub>expression in human urethral stricture tissue. ( 28979891 )
2017
12
Re: Outpatient Ultrasound Urethrogram for Assessment of Anterior Urethral Stricture: Early Experience. ( 27979534 )
2017
13
Caring for infants with posterior urethral valves: A qualitative study of parents' experiences. ( 29110519 )
2017
14
The predictive value of platelet to lymphocyte and neutrophil to lymphocyte ratio in determining urethral stricture after transurethral resection of prostate. ( 28861306 )
2017
15
A rare presentation of alkaptonuria: Extensive prostatic calculi with highlight of stones found in a unique paraprostatic urethral diverticulum. ( 28779694 )
2017
16
Role of urodynamics in management of urethral diverticulum in females. ( 28807625 )
2017
17
Definition of Successful Treatment and Optimal Follow-up after Urethral Reconstruction for Urethral Stricture Disease. ( 27908363 )
2017
18
Successful outcome of macrolide-resistant Mycoplasma genitalium urethritis after spectinomycin treatment: a case report. ( 27707988 )
2017
19
Histological and Biochemical Evaluation of Urethral Scar following Three Different Hypospadias Repairs: An Experimental Study in Rabbits. ( 28838000 )
2017
20
Cost-effective Strategies for the Management and Treatment of Urethral Stricture Disease. ( 27908365 )
2017
21
Neisseria gonorrhoeae DNA bacterial load in men with symptomatic and asymptomatic gonococcal urethritis. ( 28148678 )
2017
22
Management of Urethral Stricture and Bladder Neck Contracture Following Primary and Salvage Treatment of Prostate Cancer. ( 28776126 )
2017
23
Three-Dimensional Computerized Model Based on the Sonourethrogram: A Novel Technique for Evaluating the Anterior Urethral Stricture. ( 28866465 )
2017
24
A novel method in decision making for the diagnosis of anterior urethral stricture: using methylene blue dye. ( 29201515 )
2017
25
Can quantity of amniotic fluid reliably predict postnatal renal function in boys with posterior urethral valves: a decision curve analysis. ( 28753736 )
2017
26
Aggressive diagnosis and treatment for posterior urethral valve as an etiology for vesicoureteral reflux or urge incontinence in children. ( 28612060 )
2017
27
Double inlay plus ventral onlay buccal mucosa graft for simultaneous penile and bulbar urethral stricture. ( 29135409 )
2017
28
Management of bladder neck stenosis and urethral stricture and stenosis following treatment for prostate cancer. ( 28791228 )
2017
29
Female Urethral Diverticulum Carcinoma: A Case Report and Literature Review. ( 28630778 )
2017
30
Microscopy of Stained Urethral Smear in Male Urethritis; Which Cutoff Should be Used? ( 28178118 )
2017
31
Syndrome of Inappropriate Secretion of Antidiuretic Hormone Caused by Carboplatin After Switching from Cisplatin in a Metastatic Urethral Cancer Patient. ( 28271051 )
2017
32
Predicting postnatal renal function of prenatally detected posterior urethral valves using fetal diffusion-weighted magnetic resonance imaging with apparent diffusion coefficient determination. ( 28453880 )
2017
33
Quantitative Real-Time Polymerase Chain Reaction for the Diagnosis of Mycoplasma genitalium Infection in South African Men With and Without Symptoms of Urethritis. ( 27898565 )
2017
34
Prevalence of Mycoplasma genitalium and other sexually transmitted infections causing urethritis among high-risk heterosexual male patients in Estonia. ( 28868962 )
2017
35
Case Report of Urethritis in a Male Patient Infected with Two Different Isolates of Multiple Drug-Resistant<i>Neisseria gonorrhoeae</i>. ( 29167794 )
2017
36
Incidence and Management of Lower Urinary Tract Symptoms After Urethral Stricture Repair. ( 28718163 )
2017
37
Urethral Diverticulum Presenting as a Large Vaginal Mass Complicating Pregnancy and Delivery. ( 29026065 )
2017
38
Large Cluster of Neisseria Meningitidis Urethritis in Columbus, Ohio, 2015. ( 28481980 )
2017
39
Preliminary Experience with Instillation of Triamcinolone Acetonide into the Urethra for Idiopathic Urethritis: A Prospective Pilot Study. ( 29023188 )
2017
40
Comparison of Diagnostic Value of Sonourethrography with Retrograde Urethrography in Diagnosis of Anterior Urethral Stricture. ( 28698753 )
2017
41
Comment on "Predicting postnatal renal function of prenatally detected posterior urethral valves using fetal diffusion-weighted magnetic resonance imaging with apparent diffusion coefficient determination". ( 28777461 )
2017
42
Clinical Characteristics of Herpes Simplex Virus Urethritis Compared With Chlamydial Urethritis Among Men. ( 28079748 )
2017
43
Diagnosis of urethral diverticulum mimicking pelvic organ prolapse with translabial ultrasonography. ( 28666694 )
2017
44
Urethroplasty and Quality of Life: Psychometric Validation of a Dutch Version of the Urethral Stricture Surgery Patient Reported Outcome Measures. ( 28850951 )
2017
45
Anterior Urethral Valve: Uncommon Association with Renal Duplicity. ( 28770138 )
2017
46
Posterior urethral valves: Impact of low birth weight and preterm delivery on the final renal outcome. ( 29071146 )
2017
47
Genomic characterization of urethritis-associated Neisseria meningitidis shows that a wide range of N. meningitidis strains can cause urethritis. ( 28904187 )
2017
48
Squamous Cell Carcinoma Penis in a Case of Urethral Stricture Due to Lichen Sclerosus Balanitis Xerotica Obliterans: A Case Report and Review of Literature. ( 28892974 )
2017
49
Prediction of need for intervention in posterior urethral valves: Use of urine osmolality. ( 29223674 )
2017
50
Haemophilus influenzae Isolated From Men With Acute Urethritis: Its Pathogenic Roles, Responses to Antimicrobial Chemotherapies, and Antimicrobial Susceptibilities. ( 28282645 )
2017

Variations for Urethritis

Expression for Urethritis

Search GEO for disease gene expression data for Urethritis.

Pathways for Urethritis

Pathways related to Urethritis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.19 CD40LG CD79A

GO Terms for Urethritis

Biological processes related to Urethritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.56 CD40LG HSPD1 PHB2 YME1L1
2 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.43 HSPD1 TLR6
3 B cell activation GO:0042113 9.4 CD79A HSPD1
4 positive regulation of interleukin-12 production GO:0032735 9.37 CD40LG HSPD1
5 positive regulation of interleukin-10 production GO:0032733 9.32 CD40LG HSPD1
6 mitochondrial calcium ion transmembrane transport GO:0006851 9.16 PHB2 YME1L1
7 positive regulation of macrophage activation GO:0043032 8.96 HSPD1 TLR6
8 B cell proliferation GO:0042100 8.8 CD40LG CD79A HSPD1

Sources for Urethritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....