MCID: URT001
MIFTS: 54

Urethritis malady

Nephrological diseases category

Summaries for Urethritis

About this section
Sources:
66Wikipedia, 34MalaCards
See all sources

Fully expand this MalaCard

Download this MalaCard
Wikipedia:66 Urethritis is inflammation of the urethra. The most common symptom is painful or difficult urination. more...

MalaCards: Urethritis, also known as nongonococcal urethritis, is related to prostatitis and arthritis. An important gene associated with Urethritis is HSPD1 (heat shock 60kDa protein 1 (chaperonin)), and among its related pathways are Selected targets of GCR alpha and Legionellosis. The compounds bifidobacterium and tuberculin have been mentioned in the context of this disorder. Affiliated tissues include prostate, testes and kidney.

Aliases & Classifications for Urethritis

About this section
Sources:
9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 36MeSH, 59SNOMED-CT, 41NCIt, 28ICD9CM, 26ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological diseases


Aliases & Descriptions:

urethritis 9 11
nongonococcal urethritis 9 46
nonspecific urethritis 9 63
non-gonococcal urethritis 9
urethritis, unspecified 9
urethritis unspecified 9


External Ids:

Disease Ontology9 DOID:1343
MeSH36 D014526
NCIt41 C26904
ICD9CM28 597.80
ICD1026 N34.1, N37.0

Related Diseases for Urethritis

About this section
Sources:
18GeneCards, 19GeneDecks
See all sources

Graphical network of the top 20 diseases related to Urethritis:



Diseases related to urethritis

Symptoms for Urethritis

About this section

Drugs & Therapeutics for Urethritis

About this section
Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Urethritis

Drug clinical trials:

Search ClinicalTrials for Urethritis

Search NIH Clinical Center for Urethritis

Search CenterWatch for Urethritis

Genetic Tests for Urethritis

About this section

Anatomical Context for Urethritis

About this section
Sources:
34MalaCards
See all sources

MalaCards organs/tissues related to Urethritis:

34
Prostate, Testes, Kidney, Skin, Spinal cord, Colon, Pancreas, Bone, Small intestine, T cells, Smooth muscle, Heart, Skeletal muscle, Endothelial, Lung, Ovary, Brain, Cervix

Animal Models for Urethritis or affiliated genes

About this section

Publications for Urethritis

About this section
Sources:
53PubMed
See all sources

Articles related to Urethritis:

(show top 50)    (show all 2499)
idTitleAuthorsYear
1
Renal Parenchymal Area and Risk of ESRD in Boys with Posterior Urethral Valves. (24311709)
2013
2
First experiences with the Spannera8c temporary prostatic stent for prostatic urethral obstruction. (23886821)
2013
3
Posterior urethral valves: determinants of outcome in a developing country. (23331631)
2013
4
Robotic-Assisted Urethrolysis for Urethral Obstruction After Retropubic Bladder Neck Suspension-A Case Series Report. (24074259)
2013
5
Urethral strictures following urethral plate and proximal urethral elevation during proximal TIP hypospadias repair. (23707201)
2013
6
Commentary to 'Role of urethral bulking agents in epispadias/exstrophy complex patients' (24183655)
2013
7
Urethral diverticulum calculi in a male: a case report. (23401841)
2013
8
Re: Preputial/penile skin flap, as a dorsal onlay or tubularized flap: a versatile substitute for complex anterior urethral stricture. (23931204)
2013
9
Therapeutic outcome and quality of life between urethral and detrusor botulinum toxin treatment for patients with spinal cord lesions and detrusor sphincter dyssynergia. (24073977)
2013
10
PCR for diagnosis of male Trichomonas vaginalis infection with chronic prostatitis and urethritis. (22711929)
2012
11
Development of a porcine animal model for urethral stricture repair using autologous urothelial cells. (21398188)
2012
12
The clinical spectrum of the presenting signs and symptoms of anterior urethral stricture: detailed analysis of a single institutional cohort. (22446349)
2012
13
Coccygeal epidural with local anesthetic for catheterization and pain management in the treatment of feline urethral obstruction. (21288294)
2011
14
In vitro activity of azithromycin against Mycoplasma genitalium and its efficacy in the treatment of male Mycoplasma genitalium-positive nongonococcal urethritis. (21710162)
2011
15
Re: chlorhexidine rinse for prevention of urethritis in men linked to oral sex. (22088634)
2011
16
Management of anterior urethral stricture: an evidence-based approach. (20827208)
2010
17
Fluoroscopic stent placement for the relief of malignant urethral obstruction in a cat. (21091459)
2010
18
A rare cause of ascites in a newborn: posterior urethral valve. (20158664)
2010
19
The new pattern of urethral stricture disease in Lagos, Nigeria. (19606199)
2009
20
Bulbar urethral ligation for managing persistent urinary incontinence in young men with myelomeningocele. (19245443)
2009
21
Posterior urethral valves are often associated with cryptorchidism and inguinal hernias. (18554641)
2008
22
Staged pendulous-prostatic anastomotic urethroplasty followed by reconstruction of the anterior urethra: an effective treatment for long-segment bulbar and membranous urethral stricture. (16904816)
2007
23
A comparison of clinical features between chlamydial and non-chlamydial urethritis in men negative for gonococcal infection who attended a urological outpatient clinic in Japan. (17211572)
2007
24
Management of urethral hemangiomas associated with Klippel-Trenaunay-Weber syndrome by endoscopic sclerotherapy. (17645615)
2007
25
Renal transplantation in children with posterior urethral valves. (16491414)
2006
26
Urethral obstruction due to lobular mesonephric hyperplasia of the vagina--a case report. (16758778)
2005
27
Suprapubic electroresection of prostate in three patients with benign prostatic hyperplasia and previous surgery for long urethral stricture. (15833539)
2005
28
Asymptomatic Chlamydia trachomatis-negative non-gonococcal urethritis. (15899091)
2005
29
Long-term followup of bilateral high (sober) urinary diversion in patients with posterior urethral valves and its effect on bladder function. (15821568)
2005
30
Meningococcal urethritis in a heterosexual man. (15278728)
2004
31
Transvaginal sonographic findings in diagnosis and treatment of urethral stricture. (14682433)
2003
32
Prevalence of asymptomatic chlamydial urethritis in military recruits in the Celje region, Slovenia. (14624741)
2003
33
Posterior urethral valves: prognostic factors. (12699486)
2003
34
Risk behaviours associated with urethritis and genital ulcer disease in prison inmates, Sindh, Pakistan. (15568455)
2002
35
Increased urinary transforming growth factor-beta(1) excretion in children with posterior urethral valves. (10925100)
2000
36
Equal symptomatic outcome after antibacterial treatment of acute lower urinary tract infection and the acute urethral syndrome in adult women. (10555247)
1999
37
Urethritis and cervicitis. (10330757)
1999
38
Urethral diverticulum and urethrocutaneous fistula presenting as a mass over the medical thigh. (9722775)
1998
39
Congenital posterior urethral obstruction: the historical perspective. (9156879)
1997
40
Immunity to reinfection and immunization of male guinea pigs against urethral infection with the agent of guinea pig inclusion conjunctivitis. (8919742)
1996
41
Pseudo-haematuria caused by utero-urethral fistula from Mayer-Rokitansky-KA1ster-Hauser syndrome. (7788277)
1995
42
Prevention of urethral stricture recurrence using clean intermittent self-catheterization. (8032838)
1994
43
Mercapto-acetyltriglycine (MAG 3) renography and indirect radionuclide cystography in posterior urethral valves. (7827852)
1994
44
Female urethral cancer--an overview. (3429167)
1987
45
Urinary tract infections and the urethral syndrome in adult women: pathogenesis, diagnosis, and therapy. (3902456)
1985
46
The ultrastructure of human male urethral stricture. (1222353)
1975
47
Carcinoma of Skene's gland associated with urethral diverticulum: a case report. (4369830)
1974
48
Congenital urethral membranes causing urethral obstruction. (4810775)
1974
49
Urethral stricture. (4691433)
1973
50
Case of Vesico-urethral Calculus. (19983442)
1923

Variations for Urethritis

About this section

Expression for genes affiliated with Urethritis

About this section
Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Urethritis

Search GEO for disease gene expression data for Urethritis.

Pathways for genes affiliated with Urethritis

About this section
Sources:
51PathCards, 13EMD Millipore, 31KEGG, 61Thomson Reuters, 56Reactome
See all sources

Pathways related to Urethritis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5IL8, HSPD1
29.5IL8, HSPD1
3
Show member pathways
Transcription NF kB signaling pathway61
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response61
9.4IL8, DEFB4A
4
Show member pathways
9.2DEFA5, DEFB4A

Compounds for genes affiliated with Urethritis

About this section
Sources:
46Novoseek, 25HMDB, 12DrugBank, 30IUPHAR, 52PharmGKB, 62Tocris Bioscience
See all sources

Compounds related to Urethritis according to GeneCards/GeneDecks:

(show top 50)    (show all 61)
idCompoundScoreTop Affiliating Genes
1bifidobacterium4610.0HSPD1, LTF
2tuberculin469.9CD79A, HSPD1
3hypothiocyanite46 2510.9LTF, CD79A
4lactulose469.9CD79A, LTF
5pneumococcal469.9CD79A, LTF
6thiocyanate46 2510.9CD79A, LTF
7toxin-1469.8IL8, HSPD1
8pmma469.8LTF, CD79A
9fluconazole46 1210.8LTF, CD79A
10hcec469.8IL8, DEFB4A
11citric acid46 30 25 1212.7LTF, HSPD1
12azithromycin46 1210.7CD79A, IL8
13lipoteichoic acid469.7IL8, DEFB4A
14budesonide46 52 1211.6LTF, IL8
15protamine469.5LTF, IL8
16doxycycline46 1210.5LTF, CD79A, HSPD1
17sulfasalazine30 46 52 1212.5CD79A, IL8
18flagellin46 3010.5DEFB4A, HSPD1, IL8
19anti-fungal469.5DEFB4A, CD79A, LTF
20citrate469.5LTF, CD79A, HSPD1
21salbutamol46 52 30 25 1213.5IL8, CD79A
22polymyxin b469.5HSPD1, IL8, LTF
23indomethacin46 30 62 1212.4LTF, CD79A, HSPD1
24polysaccharide469.4HSPD1, CD79A, LTF
25rantes469.4DEFB4A, HSPD1, IL8
26n-formylmethionyl-leucylphenylalanine469.4LTF, IL8
27fibrinogen469.4LTF, CD79A, HSPD1
28pd 98,059469.3DEFB4A, HSPD1, IL8
29clarithromycin46 1210.3IL8, CD79A, LTF
30methacholine46 52 1211.3LTF, CD79A, IL8
31neopterin469.3LTF, CD79A, IL8
32hyaluronic acid46 2510.3LTF, CD79A, IL8
33mannose469.2DEFB4A, HSPD1, CD79A, LTF
34peptidoglycan46 3010.1IL8, DEFB4A
35paraffin469.1DEFB4A, HSPD1, CD79A, LTF
36hbd2469.1IL8, DEFA5, DEFB4A
37endotoxin469.1LTF, IL8, HSPD1, DEFB4A
38retinoic acid46 2510.0DEFB4A, HSPD1, CD79A, LTF
39pge2469.0LTF, CD79A, IL8
40lactate469.0HSPD1, IL8, CD79A
41n acetylcysteine468.9HSPD1, IL8, CD79A, LTF
42superoxide46 259.9LTF, IL8, HSPD1
43cyclosporin a46 30 6210.9LTF, CD79A, IL8, HSPD1
44h2o2468.9HSPD1, IL8, CD79A, LTF
45histamine46 30 2510.9DEFB4A, IL8, CD79A, LTF
46heparin46 30 25 1211.9DEFB4A, IL8, CD79A, LTF
47vegf468.9HSPD1, IL8, CD79A, LTF
48estrogen468.6DEFB4A, HSPD1, PHB2, CD79A, LTF
49dexamethasone46 52 30 1211.5LTF, CD79A, IL8, HSPD1, DEFB4A
50cysteine468.5DEFB4A, HSPD1, IL8, CD79A, LTF

GO Terms for genes affiliated with Urethritis

About this section
Sources:
17Gene Ontology
See all sources

Cellular components related to Urethritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granuleGO:0301419.3LTF, HSPD1
2Golgi lumenGO:0057969.2DEFA5, DEFB4A
3extracellular spaceGO:0056158.2LTF, IL8, HSPD1, DEFA5
4extracellular regionGO:0055768.1DEFB4A, DEFA5, IL8, LTF

Biological processes related to Urethritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1B cell activationGO:0421139.5CD79A, HSPD1
2chemotaxisGO:0069359.4IL8, DEFB4A
3B cell proliferationGO:0421009.3CD79A, HSPD1
4antibacterial humoral responseGO:0197319.2LTF, DEFA5

Products for genes affiliated with Urethritis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Urethritis

About this section
4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet