Urethritis malady

Wikipedia: Urethritis is inflammation of the urethra. The most common symptom is painful or difficult urination.⁴⁴ more...

MalaCards: Urethritis, also known as nonspecific urethritis, is related to urethral syndrome and urethral diverticulum. An important gene associated with Urethritis is KLK3 (kallikrein-related peptidase 3), and among its related pathways are ACE Inhibitor Pathway, Pharmacodynamics and Bacterial infections in CF airways. The compounds isoproterenol and captopril have been mentioned in the context of this disorder. Affiliated tissues include prostate and t cells, and related mouse phenotypes are craniofacial and homeostasis/metabolism.

Aliases & Descriptions:

urethritis 6 8 nonspecific urethritis 6 43 nongonococcal urethritis (disorder) 6 urethritis unspecified (disorder) 6

non-gonococcal urethritis 6 nongonococcal urethritis 32 urethritis, unspecified 6 urethritis (disorder) 6

Diseases related to urethritis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 635)

id	Related Disease	Score	Top Affiliating Genes
1	urethral syndrome	33.9	BCKDHA, MN1, KLK4
2	urethral diverticulum	32.2	CEACAM5, MIR4273, CYS1, NKX3-1
3	urethral stricture	32.0	KLHL24, CIAPIN1, MEMO1, GRAP, FAT4, CTGF
4	posterior urethral valves	31.8	ACE, ACE2, AGT, AGTR1, TGFB1
5	urethral intrinsic sphincter deficiency	31.2	LPP, MYBPC1, CLPP, PARP15, MEOX2, ALPP
6	urethral obstruction	30.8	VSIG4, BOLL, BCL2L10, CASK, TRPC4AP, PRUNE
7	hypospadias	28.5	BNC2, GRAP, ESR1, CTGF, PRUNE
8	reactive arthritis	27.1	CD79A, HSPD1, HLA-B, LTF
9	paine syndrome	24.5	IL8, CALCA, HLA-B, TNF, DRD2, KLK3
10	leiomyoma	24.1	CHGA, CDH1, IL8, ESR1, TNF, DRD2
11	sinusitis	22.0	BGLAP, LACTB, CD79A, IL8, ALPP, CALCA
12	adenocarcinoma	18.8	BNC2, BIRC2, BGLAP, CHGA, CEACAM5, CEACAM3
13	cervicitis	17.7	BIRC2, BCL2L10, CHGA, CEACAM5, CEACAM3, CD79A
14	prostatitis	17.6	LPP, BNC2, BIRC2, CLPP, BGLAP, BCL2A1
15	urinary tract obstruction	13.9	KLK3, ACE, TGFB1, PRUNE
16	renal tubular dysgenesis	13.9	ACE, AGT, AGTR1
17	mitral valve disease	13.9	ACE, AGT, AGTR1
18	neurogenic bladder	13.8	KLHL24, LPP, BCL2L10, MEOX2, CASK, KLK3
19	renal vascular disease	13.8	HSPD1, CTGF, ACE
20	anuria	13.8	ACE, AGT, AGTR1
21	ischemic optic neuropathy	13.7	ACE, G6PD, AGT, AGTR1
22	otosclerosis	13.7	ACE, AGT, AGTR1, TGFB1
23	neurocirculatory asthenia	13.7	LACTB, ACE, AGT, AGTR1, TGFB1
24	postural orthostatic tachycardia syndrome	13.6	NOS1, ACE2, AGT, AGTR1
25	nephrosclerosis	13.6	CALCA, CTGF, ACE, ACE2, AGTR1, TGFB1
26	sex cord-gonadal stromal tumor	13.6	CEACAM5, ALPP, KRT7, NPY
27	endodermal sinus tumor	13.6	CEACAM5, ALPP, KRT7
28	normal pressure hydrocephalus	13.6	ACE, TGFB1, NPY, GAL
29	fibromuscular dysplasia	13.6	ACE, AGT, AGTR1
30	salpingitis	13.6	CD79A, MARVELD2, HSPD1
31	aortic coarctation	13.6	EDN1, ACE, AGT, AGTR1
32	malignant hypertension	13.5	EDN1, ACE, AGT, AGTR1
33	ureteral disease	13.5	CDH1, CTGF, TGFB1
34	oligohydramnios	13.5	EDN1, ACE, AGT, AGTR1, PRUNE
35	hypertrophic pyloric stenosis	13.5	BLVRB, HMOX2, NOS1, TGFB1
36	panhypopituitarism	13.5	BGLAP, ALPP, CALCA, KLK3
37	breast cyst	13.5	CALCA, KLK3, ACE, TGFB1
38	anus basaloid carcinoma	13.5	CEACAM3, ALPP, CALCA
39	eisenmenger syndrome	13.5	EDN1, ACE, TGFB1
40	microsporidiosis	13.5	LTF, DEFB4A, DEFA5
41	enthesopathy	13.5	MRAP, HLA-B, PHB2
42	pyloric stenosis	13.5	BLVRB, HMOX2, NOS1, TGFB1
43	mucoepidermoid carcinoma	13.5	CHGA, CEACAM5, CALCA, KRT7
44	signet ring basal cell carcinoma	13.4	CHGA, CEACAM5, CDH1, KRT7
45	prostatic hypertrophy	13.4	BCL2L10, ESR1, KLK3, SIRPA, ADRA1A
46	intestinal perforation	13.4	CEACAM3, TRPC4AP, NOS1
47	vulvovaginal candidiasis	13.4	CD79A, DEFB4A, DEFA5
48	whipple disease	13.4	MRAP, HSPD1, HLA-B
49	orthostatic hypotension	13.4	CHGA, CALCA, ACE, G6PD, AGT, AGTR1
50	hepatic fibrosis renal cysts mental retardation	13.4	IFNA2, CTGF, ACE2, AGTR1, TGFB1

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to urethritis:

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MGI Mouse Phenotypes related to urethritis:

²⁵ (show all 21)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	craniofacial phenotype	MP:0005382	INF	, CYP26A1, CASK, MEOX2, , ZIC3
2	homeostasis/metabolism phenotype	MP:0005376	INF	ACE2, EDN1, , LTF, NFKBIA, NFKB1
3	mortality/aging	MP:0010768	INF	ADRA1B, NOS1, PHB2, NFKBIA, , EDN1
4	liver/biliary system phenotype	MP:0005370	10.2	SIRPA, AGT, PLIN1, CYS1, DRD2, MEOX2
5	hematopoietic system phenotype	MP:0005397	10.0	SIRPA, PURA, CYS1, GRAP, MEOX2, CIAPIN1
6	endocrine/exocrine gland phenotype	MP:0005379	9.9	GAL, NKX3-1, STC1, PHB2, CYS1, TBPL1
7	embryogenesis phenotype	MP:0005380	9.7	NKX3-1, G6PD, CYP26A1, ALPP, FAT4, MEOX2
8	renal/urinary system phenotype	MP:0005367	9.3	ADRA1B, ADRA1A, AGTR1, AGT, ACE2, CYS1
9	integument phenotype	MP:0010771	8.8	GAL, NEU1, NFKBIA, PHB2, PLIN1, DRD2
10	nervous system phenotype	MP:0003631	7.8	G6PD, AGT, TGFB1, NPY, NEU1, ADRA1B
11	immune system phenotype	MP:0005387	7.7	CYS1, NOS1, NFKBIA, LTF, AGTR1, PURA
12	reproductive system phenotype	MP:0005389	7.7	CYP26A1, PHB2, AGT, TGFB1, STC1, NKX3-1
13	adipose tissue phenotype	MP:0005375	7.5	ACE, AGT, TGFB1, NPY, ADRA1B, NOS1
14	muscle phenotype	MP:0005369	6.5	NFKB1, EDN1, ACE2, AGT, TGFB1, NEU1
15	cardiovascular system phenotype	MP:0005385	5.5	ACE2, ACE, EDN1, NOS1, CTGF, G6PD
16	cellular phenotype	MP:0005384	5.1	ACE, NFKBIA, NFKB1, PHB2, NOS1, CTGF
17	respiratory system phenotype	MP:0005388	INF	PURA, ACE2, NOS1, DRD2, HMOX2, CALCA
18	skeleton phenotype	MP:0005390	INF	CYP26A1, CTGF, NOS1, NFKB1, NKX3-1, NEU1
19	digestive/alimentary phenotype	MP:0005381	INF	CYP26A1, CYS1, CTGF, NOS1, EDN1, TGFB1
20	behavior/neurological phenotype	MP:0005386	INF	AGT, PURA, NPY, NKX3-1, NEU1, SIRPA
21	growth/size phenotype	MP:0005378	INF	AGT, ACE, , NFKBIA, NFKB1, PHB2

Articles related to urethritis:

(show all 38)

id	Title	Authors	Year	Affiliating Genes
1	Human balanced translocation and mouse gene inactivat ion implicate Basonuclin 2 in distal urethral development. (21368915)	Bhoj E.J.... Zinn A.R.	2011	BNC2
2	E-cadherin expression in male urethral smears and cor relation with PCR-based detection of human papillomavirus infection. (19998427)	Tena-Suck M.L.... Astudillo-de la Vega H.	2010	CDH1
3	Distribution and significance of I+1-adrenoceptor sub types in patients with chronic prostatitis in prostate, bladder detrusor and po sterior urethral tissue]. (21223784)	Yang Y.... Shen J.H.	2010	ADRA1B, ADRA1A
4	Growth inhibition and apoptosis induction by tumor ne crosis factor-alpha in human urethral rhabdosphincter satellite cells. (20403612)	Hanada M.... Mimata H.	2010	TNF, CASP8, NFKBIA
5	Factors affecting urethral stricture development afte r radical retropubic prostatectomy. (19165616)	Altinova S.... Balbay M.D.	2009	KLK3
6	Effects of long-term dietary soy treatment on female urethral morphology and function in ovariectomized nonhuman primates. (18804802)	Gratzke C.... Badlani G.	2008	EDN1
7	Increased expression of connective tissue growth factor in patients with urethral stricture. (18648180)	Zhang P.... Bu H.	2008	CTGF
8	Angiotensin-converting enzyme gene polymorphism in North-west Indian children with posterior urethral valves. (18947757)	Narasimhan K.L.... Kaur B.	2007	ACE
9	Interleukin-8 levels in seminal plasma in chronic prostatitis/chronic pelvic pain syndrome and nonspecific urethritis. (16643489)	Khadra A.... Hay P.	2006	IL8
10	Dopaminergic mechanisms controlling urethral function in rats. (16721842)	Ogawa T.... Yoshimura N.	2006	DRD2
11	Female para-urethral adenocarcinoma: histological and immunohistochemical study. (15661069)	Kato H.... Nishizawa O.	2005	KLK3, CHGA, CEACAM3
12	Low renin-angiotensin system activity gene polymorphism and dysplasia associated with posterior urethral valves. (16006956)	Peruzzi L.... Coppo R.	2005	ACE2, ACE, AGTR1
13	Distinct defensin profiles in Neisseria gonorrhoeae and Chlamydia trachomatis urethritis reveal novel epithelial cell-neutrophil interactions. (16040996)	Porter E.... Quayle A.J.	2005	DEFA5, DEFB4A
14	Urethral leiomyoma expressing estrogen receptors. (15242374)	Kato T.... Inoue T.	2004	ESR1
15	Gonococcal porin IB activates NF-kappaB in human urethral epithelium and increases the expression of host antiapoptotic factors. (15501771)	Binnicker M.J.... Apicella M.A.	2004	NFKB1, PTGS2, BIRC2
16	Lactoferrin assay in urethritis and urethral prostatitis (12942724)	LutskiA- D.L.... Miroshnikov V.M.	2003	LTF
17	Antibodies to Chlamydia trachomatis heat-shock protein 60 kDa and detection of Mycoplasma genitalium and ureaplasma urealyticum are associated independently with chronic nongonococcal urethritis. (12567170)	Horner P.... Taylor-Robinson D.	2003	HSPD1
18	Multiple vesico-urethral biopsies following radical prostatectomy: the predictive roles of TRUS, DRE, PSA and the pathological stage. (14499673)	Scattoni V.... Rigatti P.	2003	KLK3
19	Receptor-mediated endocytosis of Neisseria gonorrhoeae into primary human urethral epithelial cells: the role of the asialoglycoprotein receptor. (11722733)	Harvey H.A.... Apicella M.A.	2001	ASGR2
20	Congenital prepubic sinus: a variant of dorsal urethral duplication suggested by immunohistochemical analysis. (11586253)	Huang C.C.... Chuang J.H.	2001	KRT7, KRT3
21	External genitalia formation: role of fibroblast growth factor, retinoic acid signaling, and distal urethral epithelium. (11795391)	Ogino Y.... Yamada G.	2001	CYP26A1
22	Increased urinary transforming growth factor-beta(1) excretion in children with posterior urethral valves. (10925100)	MacRae Dell K.... Schulman S.L.	2000	TGFB1
23	Endocrine cell distribution and expression of tissue- associated antigens in human female paraurethral duct: possible clue to the ori gin of urethral diverticular cancer. (10701885)	Ogihara S.... Kato H.	2000	CEACAM5
24	Female urethral adenocarcinoma: immunohistochemical evidence of more than 1 tissue of origin. (10332458)	Murphy D.P.... Weiss R.E.	1999	KLK3
25	Co-localization of carbon monoxide and nitric oxide synthesizing enzymes in the human urethral sphincter. (10332482)	Ho K.M.... Noble J.G.	1999	HMOX2
26	Estrogen receptors in the human male prostatic urethr a and prostate in prostatic cancer and benign prostatic hyperplasia. (10515086)	BA... Andersson K.E.	1999	ESR1
27	Nitric oxide synthase in the heterogeneous population of intramural striated muscle fibres of the human membranous urethral sphincter. (9474237)	Ho K.M.... Andersson K.E.	1998	NOS1, BLVRB
28	Neurotransmitters in the human urethral sphincter in the absence of voiding dysfunction. (9840338)	von Heyden B.... Hertle L.	1998	CALCA, NPY, GAL
29	Carcinoembryonic antigen positive adenocarcinoma of a female urethral diverticulum: case report and review of the literature. (9624564)	Kato H.... Nishizawa O.	1998	CEACAM5
30	Bone metabolism following bladder substitution with t he ileal urethral Kock reservoir. (9117211)	Poulsen A.L.... Steven K.	1997	BGLAP
31	Association of antibodies to Chlamydia trachomatis heat-shock protein 60 kD with chronic nongonococcal urethritis. (9145740)	Horner P.J.... Taylor-Robinson D.	1997	HSPD1
32	Ultrastructural analysis of primary human urethral ep ithelial cell cultures infected with Neisseria gonorrhoeae. (9169783)	Harvey H.A.... Apicella M.A.	1997	ASGR2
33	Buccal mucosal urethral replacement. (7715003)	Duckett J.W.... Baskin L.S.	1995	INTS12
34	Estrogen receptors in a urethral leiomyoma presenting in pregnancy. (7813754)	Kesari D.... Sibi J.	1994	ESR1
35	Treatment of urethral condylomata acuminata or flat condylomata with interferon-alpha 2a. (7966664)	Cardamakis E.... Papathanasiou Z.	1994	IFNA2
36	Histochemistry of human urethral glands. (2009030)	Sirigu P.... Hafez E.S.	1991	PGD, G6PD
37	Comparison of single-dose ceftizoxime or ceftriaxone in the treatment of uncomplicated urethral gonorrhea. (1948517)	Goldstein A.M.... Wickler M.A.	1991	LACTB
38	Resistance to human serum of gonococci in urethral exudates is reduced by neuraminidase. (1978333)	Parsons N.J.... Smith H.	1990	NEU1

Genes related to urethritis according to GeneCards:

(show top 50)    (show all 79)

id	Symbol	Description	Score	GeneCards Section Context
1	KLK3	kallikrein-related peptidase 3	11.0	Publications
2	MIR4273	microRNA 4273	11.0
3	GRAP	GRB2-related adaptor protein	11.0
4	CLPP	ClpP caseinolytic peptidase, ATP-dependent, proteolytic subunit homolog (E. coli)	11.0
5	BCL2L10	BCL2-like 10 (apoptosis facilitator)	11.0
6	NKX3-1	NK3 homeobox 1	11.0
7	PRUNE	prune homolog (Drosophila)	11.0
8	BOLL	bol, boule-like (Drosophila)	11.0
9	TBPL1	TBP-like 1	11.0
10	STC1	stanniocalcin 1	11.0
11	MEOX2	mesenchyme homeobox 2	11.0
12	PARP15	poly (ADP-ribose) polymerase family, member 15	11.0
13	ACE2	angiotensin I converting enzyme (peptidyl-dipeptidase A) 2	11.0	Publications
14	PLIN1	perilipin 1	11.0
15	CTGF	connective tissue growth factor	11.0	Publications
16	MEMO1	mediator of cell motility 1	11.0
17	CEACAM5	carcinoembryonic antigen-related cell adhesion molecule 5	11.0	Publications
18	SIRPA	signal-regulatory protein alpha	11.0
19	ADRA1A	adrenoceptor alpha 1A	11.0	Publications
20	FAT4	FAT tumor suppressor homolog 4 (Drosophila)	11.0
21	CASK	calcium/calmodulin-dependent serine protein kinase (MAGUK family)	11.0
22	AGT	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	11.0	Publications
23	HSPD1	heat shock 60kDa protein 1 (chaperonin)	11.0	Publications
24	ALPP	alkaline phosphatase, placental	11.0
25	LPP	LIM domain containing preferred translocation partner in lipoma	11.0
26	AGTR1	angiotensin II receptor, type 1	11.0	Publications
27	ACE	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	11.0	Publications
28	TGFB1	transforming growth factor, beta 1	11.0	Publications
29	ZIC3	Zic family member 3	11.0
30	ASGR2	asialoglycoprotein receptor 2	11.0	Publications
31	DEFA5	defensin, alpha 5, Paneth cell-specific	11.0	Publications
32	MRAP	melanocortin 2 receptor accessory protein	11.0
33	CYS1	cystin 1	11.0
34	CYP26A1	cytochrome P450, family 26, subfamily A, polypeptide 1	11.0	Publications
35	KRT3	keratin 3	11.0	Publications
36	VSIG4	V-set and immunoglobulin domain containing 4	11.0
37	CIAPIN1	cytokine induced apoptosis inhibitor 1	11.0
38	MARVELD2	MARVEL domain containing 2	11.0
39	INTS12	integrator complex subunit 12	11.0	Publications
40	HMOX2	heme oxygenase (decycling) 2	11.0	Publications
41	PGD	phosphogluconate dehydrogenase	11.0	Publications
42	KLHL24	kelch-like 24 (Drosophila)	11.0
43	BCL2A1	BCL2-related protein A1	11.0	Publications
44	DEFB4A	defensin, beta 4A	11.0	Publications
45	ADRA1B	adrenoceptor alpha 1B	11.0	Publications
46	PURA	purine-rich element binding protein A	11.0
47	BLVRB	biliverdin reductase B (flavin reductase (NADPH))	11.0	Publications
48	BIRC2	baculoviral IAP repeat containing 2	11.0	Publications
49	PHB2	prohibitin 2	11.0
50	TRPC4AP	transient receptor potential cation channel, subfamily C, member 4 associated protein	11.0

Pathways related to urethritis according to GeneDecks:

(show all 38)

id	Pathway	Score	Top Affiliating Genes
1	ACE Inhibitor Pathway, Pharmacodynamics34	10.8	AGTR1, ACE2
2	Bacterial infections in CF airways41	10.7	DEFB4A
3	RIG-I-like receptor signaling pathway20	10.6	CASP8
4	Renin-angiotensin system20	10.6	AGTR1, AGT, ACE2, ACE
5	Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics34	10.6	TGFB1, AGTR1, AGT, ACE2, ACE
6	DR3 Signaling36	9.9	NFKBIA, NFKB1, CASP8, BIRC2
7	TWEAK Pathway36	9.9	NFKBIA, NFKB1, CASP8, BIRC2
8	Pathways in cancer20	9.8	NKX3-1, TGFB1, NFKBIA, CASP8, CDH1, BIRC2
9	Apoptosis and survival_Anti-apoptotic TNFs/NF-kB/IAP pathway41	9.5	NFKBIA, NFKB1, TNF, BIRC2
10	Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway10	9.4	NFKBIA, NFKB1, TNF, BIRC2
11	TNFR2 Pathway36	9.4	NFKBIA, NFKB1, TNF, BIRC2
12	TNFR1 Pathway36	9.3	NFKBIA, NFKB1, TNF, CASP8, BIRC2
13	Apoptosis and survival_TNFR1 signaling pathway41	9.3	NFKBIA, NFKB1, TNF, CASP8, BIRC2
14	Apoptosis and survival TNFR1 signaling pathway10	9.3	NFKBIA, NFKB1, TNF, CASP8, BIRC2
15	TNF Signaling36	9.3	NFKBIA, NFKB1, TNF, CASP8, BIRC2
16	Apoptosis and survival_Lymphotoxin-beta receptor signaling41	9.3	NFKBIA, NFKB1, IL8, BIRC2
17	Apoptosis through Death Receptors36	9.3	NFKBIA, NFKB1, TNF, CASP8, BIRC2
18	Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway10	9.2	NFKBIA, NFKB1, TNF, BCL2A1
19	Apoptosis and survival Lymphotoxin-beta receptor signaling10	9.2	NFKBIA, NFKB1, IL8, BIRC2
20	TRAF Pathway36	9.2	TLR6, NFKBIA, NFKB1, TNF, CASP8, BIRC2
21	Apoptosis and survival_APRIL and BAFF signaling41	9.1	NFKBIA, NFKB1, PTGS2, BCL2A1
22	Apoptosis20	9.1	NFKBIA, NFKB1, TNF, CASP8, BIRC2
23	Toxoplasmosis20	9.1	TGFB1, NFKBIA, NFKB1, TNF, CASP8, BIRC2
24	Apoptosis and survival APRIL and BAFF signaling10	9.1	NFKBIA, NFKB1, PTGS2, BCL2A1
25	Cellular Apoptosis Pathway36	9.1	TGFB1, NFKBIA, NFKB1, CTGF, TNF, CASP8
26	Tuberculosis20	9.0	TGFB1, TLR6, NFKB1, TNF, CASP8, HSPD1
27	Apoptosis and survival_Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway41	8.9	NFKB1, TNF, BCL2A1, NFKBIA
28	NOD-like receptor signaling pathway20	8.8	NFKBIA, NFKB1, TNF, CASP8, IL8, BIRC2
29	Chagas disease (American trypanosomiasis)20	8.7	IL8, TGFB1, TLR6, ACE, NFKBIA, NFKB1
30	Leishmaniasis20	8.7	TGFB1, NFKBIA, NFKB1, PTGS2, TNF
31	Toll-like receptor signaling pathway20	8.5	TLR6, NFKBIA, NFKB1, TNF, CASP8, IFNA2
32	Immune response_MIF-mediated glucocorticoid regulation41	8.4	NFKBIA, NFKB1, PTGS2, TNF, IL8
33	Immune response MIF-mediated glucocorticoid regulation10	8.3	NFKBIA, NFKB1, PTGS2, TNF, IL8
34	Immune response_MIF in innate immunity response41	8.3	NFKBIA, NFKB1, PTGS2, TNF, IL8
35	Immune response MIF in innate immunity response10	8.3	NFKBIA, NFKB1, PTGS2, TNF, IL8
36	Colorectal Cancer Metastasis36	8.1	TGFB1, TLR6, NFKB1, PTGS2, TNF, CDH1
37	Immune response IL-1 signaling pathway10	8.0	EDN1, NFKBIA, NFKB1, PTGS2, TNF, IL8
38	Immune response_IL-1 signaling pathway41	8.0	EDN1, NFKBIA, NFKB1, PTGS2, TNF, IL8

Compounds related to urethritis according to GeneDecks:

(show top 50)    (show all 220)

id	Compound	Score	Top Affiliating Genes
1	isoproterenol32 9 9	12.1	CHGA, MYBPC1, PLIN1, LTF
2	captopril32 42 9 9	13.0	AGT, ACE2, ACE, CTGF, CD79A, CALCA
3	glucose32	10.0	STC1, SIRPA, PGD, KRT7, HMOX2, BLVRB
4	sodium nitroprusside32	10.0	BLVRB, NFKBIA, G6PD, AGTR1, NPY
5	n acetylcysteine32	9.7	CD79A, HSPD1, CDH1, CTGF, LTF, AGT
6	acth32	9.6	BCL2A1, CEACAM3, IFNA2, NFKBIA, NPY, GAL
7	pge232	9.6	NOS1, LTF, EDN1, AGT, CDH1
8	h2o232	9.5	PGD, AGTR1, AGT, BGLAP, LTF, NOS1
9	nifedipine32 9 9	11.4	AGT, AGTR1, EDN1, TGFB1, NPY, G6PD
10	clonidine32 9 9	11.4	BGLAP, NPY, CHGA, CALCA, AGTR1, TGFB1
11	epinephrine32 9 18 9	12.3	ADRA1A, GAL, CHGA, CD79A, CASP8, KLK3
12	b 72332	9.1	CDH1, CHGA, CEACAM5, CEACAM3, KRT7, ALPP
13	dopamine32 9 18 9	12.1	AGT, NFKBIA, ADRA1B, NEU1, ADRA1A, GAL
14	polyethylene glycol32	9.0	IFNA2, CD79A, CDH1, NEU1, TGFB1, G6PD
15	thyroxine32 18	10.0	BGLAP, CALCA, ALPP, IFNA2, CD79A, CEACAM3
16	etoposide32 42 9 9	11.9	CHGA, KLK3, TGFB1, GAL, NFKBIA, HSPD1
17	methacholine32 9 9	10.9	CD79A, CALCA, TGFB1, AGTR1, NOS1, LTF
18	polysaccharide32	8.9	CD79A, HSPD1, CASP8, HLA-B, LTF, KLK3
19	formaldehyde32 18	9.8	TGFB1, KLK3, CDH1, NOS1, BLVRB, CHGA
20	retinoid32	8.6	CASP8, ALPP, IFNA2, CDH1, ESR1, CYP26A1
21	simvastatin32 34 42 9 18 9	13.5	TNF, AGT, IL8, AGTR1, BGLAP, ALPP
22	glutamate32	8.5	HMOX2, CALCA, ALPP, CDH1, CD79A, BCL2A1
23	sb 20358032 42	9.4	TNF, CASP8, CTGF, EDN1, AGT, AGTR1
24	acetylcholine32 9 18 9	11.4	HMOX2, DRD2, NOS1, EDN1, AGT, GAL
25	doxorubicin32 34 9 9	11.4	CEACAM5, CEACAM3, CDH1, ASGR2, IFNA2, HSPD1
26	norepinephrine32 9 18 9	11.2	BCL2A1, ACE, CHGA, CD79A, ALPP, LTF
27	creatinine32	8.1	NPY, G6PD, CTGF, EDN1, HLA-B, HSPD1
28	tamoxifen32 34 9 9	11.1	BGLAP, CHGA, NOS1, CDH1, G6PD, CEACAM3
29	oxygen32 18	9.0	HMOX2, CTGF, PGD, AGTR1, AGT, G6PD
30	nitric oxide32 9 18 9	11.0	ACE, NPY, CTGF, GAL, PGD, AGT
31	superoxide32 18	8.8	G6PD, BLVRB, PGD, AGTR1, AGT, ACE2
32	calcium32 9 18 9	10.8	ALPP, GAL, MYBPC1, ADRA1B, HMOX2, CTGF
33	histamine32 18	8.8	IFNA2, NPY, NEU1, GAL, NOS1, CALCA
34	testosterone32 9 18 9	10.7	G6PD, CHGA, NOS1, BCL2A1, BGLAP, GAL
35	cisplatin32 34 9 9	10.6	CHGA, CEACAM5, IFNA2, ALPP, HSPD1, DRD2
36	adenylate32	7.5	CDH1, HLA-B, DRD2, NOS1, LTF, G6PD
37	paraffin32	7.4	BLVRB, TGFB1, AGT, KLK3, LTF, KRT7
38	pd 98,05932	7.3	TNF, CASP8, ALPP, IL8, CDH1, PLIN1
39	arginine32	7.3	GAL, AGTR1, NPY, ALPP, AGT, CHGA
40	cyclosporin a32 42	8.2	CTGF, CD79A, IL8, ALPP, NFKBIA, NOS1
41	lactate32	7.0	CDH1, PGD, NPY, TGFB1, G6PD, CHGA
42	actinomycin d32	6.8	G6PD, AGT, AGTR1, TGFB1, TNF, EDN1
43	vegf32	6.7	BIRC2, BGLAP, CHGA, CEACAM5, CEACAM3, CDH1
44	indomethacin32 9 9	8.7	HSPD1, PTGS2, CALCA, CDH1, CD79A, BLVRB
45	cycloheximide32	6.4	BIRC2, CASP8, NFKBIA, GAL, ADRA1B, KLK3
46	dexamethasone32 42 34 9 9	9.6	IL8, ALPP, CDH1, CD79A, CHGA, BCL2A1
47	progesterone32 42 9 18 9	INF	STC1, NKX3-1, BCL2A1, , KRT7, HMOX2
48	estrogen32	INF	NPY, CTGF, CALCA, ALPP, CDH1, CEACAM3
49	serine32	INF	G6PD, AGT, CHGA, CLPP, BGLAP, NFKBIA
50	retinoic acid32 42 18	INF	ALPP, NPY, NKX3-1, NEU1, GAL, DEFB4A

Cellular components related to urethritis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	secretory granule	GO:030141	9.5	GAL, DEFA5, LTF, HSPD1, CHGA
2	extracellular space	GO:005615	7.5	BGLAP, NPY, STC1, DEFA5, TGFB1, AGT
3	extracellular region	GO:005576	INF	EDN1, ACE2, AGT, TGFB1, DEFB4A, DEFA5

Biological processes related to urethritis according to GeneDecks:

(show all 22)

id	Name	GO ID	Score	Top Affiliating Genes
1	regulation of systemic arterial blood pressure by renin-angiotensin	GO:003081	10.6	ACE, ACE2, AGTR1
2	regulation of vasodilation	GO:042312	10.6	AGTR1, ACE2, ACE
3	positive regulation of cellular protein metabolic process	GO:032270	10.4	TGFB1, AGTR1, AGT, NFKBIA
4	regulation of vasoconstriction	GO:019229	10.3	EDN1, ACE, ACE2, AGT, AGTR1
5	regulation of cell proliferation	GO:042127	10.1	AGTR1, AGT, ACE2, NFKBIA, BIRC2
6	positive regulation of macrophage derived foam cell differentiation	GO:010744	10.0	AGTR1, AGT, NFKB1
7	positive regulation of renal sodium excretion	GO:035815	9.9	DRD2, EDN1, AGT
8	regulation of sodium ion transport	GO:002028	9.9	TGFB1, NOS1, DRD2
9	elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway	GO:051482	9.9	AGTR1, EDN1, DRD2, CALCA
10	feeding behavior	GO:007631	9.8	CALCA, DRD2, NPY, GAL
11	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO:006919	9.7	NKX3-1, TNF, CASP8, HSPD1, BCL2L10
12	response to vitamin D	GO:033280	9.6	STC1, TGFB1, PTGS2, BGLAP
13	cell-cell signaling	GO:007267	9.6	ADRA1B, ADRA1A, STC1, AGT, EDN1, CALCA
14	regulation of inflammatory response	GO:050727	9.5	AGTR1, ACE2, PTGS2, CALCA, BIRC2
15	cellular response to interleukin-1	GO:071347	9.4	NKX3-1, EDN1, NFKB1, IL8
16	anti-apoptosis	GO:006916	9.2	NFKBIA, NFKB1, TNF, CIAPIN1, BCL2L10, BCL2A1
17	positive regulation of smooth muscle contraction	GO:045987	9.0	EDN1, PTGS2, ADRA1A
18	response to estradiol stimulus	GO:032355	9.0	TGFB1, CTGF, PTGS2, ESR1, CASP8
19	calcium-mediated signaling	GO:019722	8.8	IL8, TNF, EDN1, AGTR1
20	positive regulation of nitric oxide biosynthetic process	GO:045429	8.4	ESR1, TNF, PTGS2, EDN1
21	response to drug	GO:042493	7.8	CDH1, TNF, DRD2, PTGS2, EDN1, TGFB1
22	inflammatory response	GO:006954	7.5	GAL, IL8, IFNA2, CALCA, TNF, PTGS2

Molecular functions related to urethritis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:005515	INF	VSIG4, HMOX2, TRPC4AP, TNF, DRD2, CYS1