MCID: URT001
MIFTS: 56

Urethritis malady

Nephrological category

Summaries for Urethritis

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Urethritis is inflammation of the urethra. The most common symptom is painful or difficult urination. more...

MalaCards: Urethritis, also known as nongonococcal urethritis, is related to urethral stricture and urethral syndrome. An important gene associated with Urethritis is UBR1 (ubiquitin protein ligase E3 component n-recognin 1), and among its related pathways are Renin-angiotensin system and Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics. The compounds captopril and aliskiren have been mentioned in the context of this disorder. Affiliated tissues include skin, kidney and pancreas, and related mouse phenotypes are adipose tissue and mortality/aging.

Aliases & Classifications for Urethritis

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 40NCIt, 35MeSH, 27ICD9CM, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological


Aliases & Descriptions:

urethritis 8 10
nongonococcal urethritis 8 45
nonspecific urethritis 8 61
non-gonococcal urethritis 8
urethritis, unspecified 8
urethritis unspecified 8


External Ids:

Disease Ontology8 DOID:1343
NCIt40 C26904
MeSH35 D014526
ICD9CM27 597.80
ICD1025 N34.1, N37.0

Related Diseases for Urethritis

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Urethritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 275)
idRelated DiseaseScoreTop Affiliating Genes
1urethral stricture31.7KLK3
2urethral syndrome31.4KLK4, BCKDHA
3urinary tract obstruction30.5ACE
4vesicoureteral reflux30.5AGT, AGTR1
5adenoma30.5KLK4
6ureterocele30.3CYS1
7urethral intrinsic sphincter deficiency30.2PURA
8anuria29.9ACE
9posterior urethral valve11.2
10posterior valve urethra11.2
11posterior urethral valves11.1
12urethral obstruction11.0
13urethral diverticulum11.0
14hypospadias10.7
15urethral calculus10.7
16trachoma10.7
17urethra adenocarcinoma10.5
18adenocarcinoma10.5
19urethra cancer10.5
20prune belly syndrome10.5
21gonorrhea10.4
22imperforate anus10.4
23n syndrome10.4
24epispadias10.4
25detrusor sphincter dyssynergia10.3
26lymphogranuloma venereum10.3
27urethra transitional cell carcinoma10.3
28urethra clear cell adenocarcinoma10.3
29arthritis10.3
30urethral obstruction sequence10.3
31clear cell adenocarcinoma10.3
32transitional cell carcinoma10.3
33nephrogenic adenoma10.3
34neurogenic bladder10.3
35lichen sclerosus10.3
36epididymitis10.3
37balanitis xerotica obliterans10.2
38reactive arthritis10.2
39balanitis10.2
40urethra squamous cell carcinoma10.2
41renal dysplasia10.2
42bladder neck obstruction10.2
43rhinosporidiosis10.2
44urethral false passage10.2
45urethra leiomyoma10.2
46female stress incontinence10.2
47squamous cell carcinoma10.2
48cervical ribs, sprengel anomaly, anal atresia, and urethral obstruction10.2
49pyuria10.1
50hydronephrosis10.1

Graphical network of the top 20 diseases related to Urethritis:



Diseases related to urethritis

Clinical Features for Urethritis

Drugs & Therapeutics for Urethritis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Urethritis

Drug clinical trials:

Search ClinicalTrials for Urethritis

Search NIH Clinical Center for Urethritis

Search CenterWatch for Urethritis

Genetic Tests for Urethritis

Anatomical Context for Urethritis

Sources:
33MalaCards
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MalaCards organs/tissues related to Urethritis:

33
Skin, Kidney, Pancreas, Prostate, T cells, B cells

Animal Models for Urethritis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Urethritis

Sources:
51PubMed
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Articles related to Urethritis:

(show top 50)    (show all 539)
idTitleAuthorsYear
1
Suboptimal adherence to doxycycline and treatment outcomes among men with non-gonococcal urethritis: a prospective cohort study. (24106340)
2014
2
Antimicrobial susceptibility and penicillin-binding protein 1 and 2 mutations in Neisseria gonorrhoeae isolated from male urethritis in Sapporo, Japan. (22797875)
2013
3
Clinical efficacy of sitafloxacin 100A mg twice daily for 7A days for patients with non-gonococcal urethritis. (23749142)
2013
4
Fournier's Gangrene in a Heterosexual Man: A Complication of Neisseria meningitidis Urethritis. (23304623)
2012
5
Recalibrating the Gram stain diagnosis of male urethritis in the era of nucleic acid amplification testing. (22183839)
2012
6
Association of Mycoplasma genitalium with balanoposthitis in men with non-gonococcal urethritis. (20852310)
2011
7
Chlamydia trachomatis serovar distribution and Neisseria gonorrhoeae coinfection in male patients with urethritis in Greece. (20357220)
2010
8
Intravesical steroid instillation--a novel therapeutic intervention for idiopathic urethritis of childhood. (19199232)
2009
9
A comparison of clinical features between chlamydial and non-chlamydial urethritis in men negative for gonococcal infection who attended a urological outpatient clinic in Japan. (17211572)
2007
10
Asymptomatic Chlamydia trachomatis-negative non-gonococcal urethritis. (15899091)
2005
11
Evaluation of a rapid antigen detection test for Neisseria gonorrhoeae in urine sediment for diagnosis of gonococcal urethritis in males. (15365860)
2004
12
Uroflow in murine urethritis. (15302511)
2004
13
Screening for non-gonococcal urethritis. (14769182)
2004
14
Association of Ureaplasma urealyticum (biovar 2) with nongonococcal urethritis. (15076934)
2004
15
Urinary tract infection in patients with acute non-gonococcal urethritis -- 1. (14596778)
2003
16
Urinary tract infection in patients with acute non-gonococcal urethritis. (12537729)
2002
17
Quantitative detection of Mycoplasma genitalium from first-pass urine of men with urethritis and asymptomatic men by real-time PCR. (11923372)
2002
18
Sexually transmitted infections in Estonia--syndromic management of urethritis in a European country? (11487388)
2001
19
An audit of the 'two-glass' test for urethritis. (10997506)
2000
20
Chlamydial infection. Incidence in 'non-specific' urethritis. 1972. (10911857)
2000
21
Ciprofloxacin 250 mg for treating gonococcal urethritis and cervicitis. (11221138)
2000
22
Non-gonococcal urethritis (NGU) due to trichomonas vaginalis in Ibadan. (10876736)
1999
23
Treatment with jimei'an of nongonococcal urethritis caused by Chlamydia and Ureaplasma urealyticum. (10921144)
1999
24
Practical recommendations for the drug treatment of bacterial infections of the male genital tract including urethritis, epididymitis and prostatitis. (10353299)
1999
25
Cefaclor, an alternative to third generation cephalosporins for the treatment of gonococcal urethritis in the developing world? (9582471)
1997
26
Detection of Mycoplasma genitalium and Chlamydia trachomatis DNAs in male patients with urethritis using the polymerase chain reaction. (9385602)
1997
27
Chlamydia trachomatis antibodies in serum and ejaculate of male patients without acute urethritis. (8766151)
1996
28
Chlamydial cervicitis and urethritis: single dose treatment compared with doxycycline for seven days in community based practises. (8698374)
1996
29
Comparative efficacy and safety of single oral doses of sparfloxacin versus ciprofloxacin in the treatment of acute gonococcal urethritis in men. (8737131)
1996
30
The role of Chlamydia trachomatis in urethritis and urethral symptoms in women. (7794376)
1995
31
Male urethritis with and without discharge: a clinical and microbiological study. (7482108)
1995
32
Mycoplasma genitalium: a cause of non-gonococcal urethritis? (8001961)
1994
33
Urethral stricture and urethritis in men in Scotland. (7705858)
1994
34
Single-dose oral azithromycin versus seven-day doxycycline in the treatment of non-gonococcal urethritis in males. (8396091)
1993
35
Mycoplasma genitalium: a cause of male urethritis? (7721285)
1993
36
A reappraisal of chlamydial and nonchlamydial acute non-gonococcal urethritis. (1616966)
1992
37
Clinical and microbiologic features of urethritis in men in Toulouse, France. (1907404)
1991
38
Moraxella urethritis mimicking gonorrhoea. (2032713)
1991
39
Aetiology of non-gonococcal urethritis. (1863655)
1991
40
The Limulus amoebocyte lysate assay for prediction of chlamydial infection in males with non-gonococcal urethritis: an evaluation. (1787774)
1991
41
Microbiological study of urethritis in men attending a STD clinic. (2128698)
1990
42
Recent advances in non-gonococcal urethritis: pathogenesis, investigation and treatment. (2083289)
1990
43
Chlamydia trachomatis urethritis in university men: risk factors and rates. (2185610)
1990
44
Oral ciprofloxacin versus ceftriaxone for the treatment of urethritis from resistant Neisseria gonorrhoeae in Zambia. (2113796)
1990
45
Meningococcal urethritis. (2114384)
1990
46
Diagnosing Chlamydia trachomatis urethritis by first-catch urine enzyme immunoassay in adolescent males. (2654106)
1989
47
Recent reduction in male urethritis in France. (2705606)
1989
48
Etiology of urethritis in Thai men. (2510327)
1989
49
Chronic cystitis and urethritis associated with ureaplasmal and mycoplasmal infection in primary hypogammaglobulinaemia. (7104592)
1982
50
Functional abnormalities of the bladder in children: characteristics of chronic cystitis and chronic urethritis. (5532922)
1970

Genetic Variations for Urethritis

Expression for genes affiliated with Urethritis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Urethritis

Search GEO for disease gene expression data for Urethritis.

Pathways for genes affiliated with Urethritis

Sources:
30KEGG, 54Reactome, 50PharmGKB, 38NCBI BioSystems Database
See all sources

Pathways related to Urethritis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.5ACE2
2
Hide members
10.4TGFB1, ACE2
3
Hide members
10.4ACE2, ACE, AGT

Compounds for genes affiliated with Urethritis

Sources:
45Novoseek, 29IUPHAR, 50PharmGKB, 60Tocris Bioscience, 11DrugBank, 24HMDB
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Compounds related to Urethritis according to GeneCards/GeneDecks:

(show all 48)
idCompoundScoreTop Affiliating Genes
1captopril45 29 50 60 1114.9ACE2
2aliskiren45 1111.9ACE, AGT, AGTR1
3benazepril45 1111.9AGTR1, AGT, ACE, TGFB1
4saralasin4510.9AGTR1, AGT, ACE
5eprosartan45 29 1112.9ACE, AGT, AGTR1
6perindopril45 50 1112.9AGTR1, AGT, ACE, TGFB1
7candesartan45 29 1112.9TGFB1, ACE, AGT, AGTR1, KLK3
8angiotensin ii29 2411.9AGTR1, ACE, ACE2
9lisinopril45 11 2412.9AGTR1, AGT, ACE, ACE2
10pd12331945 2911.9ACE, AGT, AGTR1
11ramipril45 1111.9TGFB1, ACE2, ACE, AGTR1
12olmesartan45 29 1112.9AGTR1, AGT, ACE
13ang ii4510.8AGTR1, AGT, ACE, TGFB1
14eplerenone45 60 29 1113.8AGTR1, ACE, ACE2
15chymostatin4510.8ACE, AGT, AGTR1
16atenolol45 29 50 11 2414.8ACE, AGT, AGTR1
17enalaprilat4510.8ACE2, ACE, AGT
18valsartan45 60 29 1113.8AGTR1, AGT, ACE
19losartan45 50 29 1113.8AGTR1, AGT, ACE, TGFB1
20telmisartan45 29 1112.8ACE, AGT, AGTR1
21temocaprilat4510.8AGTR1, ACE
22doxazosin45 1111.8ACE, AGTR1, KLK3
23irbesartan45 29 50 1113.8AGTR1, AGT, ACE
24benazepril hydrochloride6010.8ACE, ACE2
25moexipril hydrochloride6010.8ACE, ACE2
26perindopril erbumine6010.8ACE, ACE2
27hydrochlorothiazide45 50 29 11 2414.8AGTR1, AGT, ACE
28diltiazem45 29 1112.8ACE, AGT, AGTR1
29enalapril45 50 1112.8AGTR1, AGT, ACE
30spironolactone50 45 60 29 1114.8ACE, AGTR1, KLK3
31amlodipine45 50 11 2413.8ACE, AGT, AGTR1
32remikiren45 1111.8ACE, AGT
33nifedipine45 50 29 1113.7AGTR1, AGT, ACE, TGFB1
34cv 119744510.7AGT, AGTR1
35moexipril45 1111.7ACE2, ACE
36cgp42112a4510.7AGTR1, AGT
37lacidipine4510.7ACE, AGTR1
38deoxyribonucleic acid4510.7AGT, AGTR1, KLK3
39trandolapril45 1111.7ACE, AGTR1
40aspirin45 50 29 2413.6KLK3, AGTR1, ACE, TGFB1
41cilazapril45 1111.6ACE, AGTR1
42bradykinin60 29 2412.6ACE, AGTR1
43fosinopril45 1111.6AGTR1, ACE
44quinapril45 1111.5ACE, AGTR1
45norepinephrine45 11 2412.5PLIN1
46serine4510.4TGFB1, PLIN1, CLPP, AGT, AGTR1, KLK3
47sele4510.4ACE, AGT
48cholesterol45 29 11 2413.1AGTR1, AGT, PLIN1, ACE, ACE2

GO Terms for genes affiliated with Urethritis

Sources:
16Gene Ontology
See all sources

Biological processes related to Urethritis according to GeneCards/GeneDecks:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1regulation of systemic arterial blood pressure by renin-angiotensinGO:00308110.8ACE2, ACE, AGTR1
2regulation of vasoconstrictionGO:01922910.8ACE2, ACE, AGT, AGTR1
3regulation of vasodilationGO:04231210.8ACE2, ACE, AGTR1
4positive regulation of cellular protein metabolic processGO:03227010.8TGFB1, AGT, AGTR1
5angiotensin maturationGO:00200310.8ACE2, AGT, ACE
6mononuclear cell proliferationGO:03294310.7ACE, TGFB1
7positive regulation of NAD(P)H oxidase activityGO:03386410.7AGT, AGTR1
8positive regulation of reactive oxygen species metabolic processGO:200037910.7AGTR1, AGT, ACE2
9kidney developmentGO:00182210.7CYS1, AGT, AGTR1, ACE
10regulation of renal output by angiotensinGO:00201910.7AGT, ACE
11angiotensin catabolic process in bloodGO:00200510.7ACE2, ACE
12angiotensin-mediated drinking behaviorGO:00305110.7ACE2, AGT
13regulation of blood vessel size by renin-angiotensinGO:00203410.7AGTR1, AGT
14regulation of renal sodium excretionGO:03581310.7AGTR1, AGT
15renin-angiotensin regulation of aldosterone productionGO:00201810.6AGT, AGTR1
16positive regulation of cholesterol esterificationGO:01087310.6AGTR1, AGT
17positive regulation of superoxide anion generationGO:03293010.6AGT, TGFB1
18proteolysisGO:00650810.5ACE2, ACE, KLK3, KLK4, CLPP
19low-density lipoprotein particle remodelingGO:03437410.5AGTR1, AGT
20negative regulation of mitotic cell cycleGO:04593010.4TGFB1, NKX3-1
21regulation of cell proliferationGO:04212710.3AGTR1, AGT, ACE2
22positive regulation of macrophage derived foam cell differentiationGO:01074410.2AGT, AGTR1

Molecular functions related to Urethritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1bradykinin receptor bindingGO:03171110.5AGTR1, ACE
2acetyltransferase activator activityGO:01069810.5AGTR1, AGT
3carboxypeptidase activityGO:00418010.4ACE, ACE2
4peptidyl-dipeptidase activityGO:00824110.1ACE, ACE2
5protein bindingGO:00551510.1NKX3-1, PRUNE, CIAPIN1, PURA, KLK3, AGTR1

Products for genes affiliated with Urethritis

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  • Proteins
  • Lysates
  • Antibodies

Sources for Urethritis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet