MCID: URT001
MIFTS: 40

Urethritis

Categories: Nephrological diseases

Aliases & Classifications for Urethritis

MalaCards integrated aliases for Urethritis:

Name: Urethritis 12 42 14 69
Non-Gonococcal Urethritis 12 69
Nongonococcal Urethritis 12 52
Nonspecific Urethritis 69

Classifications:



External Ids:

Disease Ontology 12 DOID:1343
ICD10 33 N34.2 N37.0
ICD9CM 35 597.80
MeSH 42 D014526
NCIt 47 C26904

Summaries for Urethritis

MalaCards based summary : Urethritis, also known as non-gonococcal urethritis, is related to chlamydia and inclusion conjunctivitis. An important gene associated with Urethritis is DEFB4A (Defensin Beta 4A), and among its related pathways/superpathways is Primary immunodeficiency. The drugs Azithromycin and Doxycycline have been mentioned in the context of this disorder. Affiliated tissues include prostate, testes and kidney.

Wikipedia : 72 Urethritis is inflammation of the urethra. The most common symptom is painful or difficult urination. It... more...

Related Diseases for Urethritis

Diseases related to Urethritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 409)
id Related Disease Score Top Affiliating Genes
1 chlamydia 31.4 CD40LG HSPD1
2 inclusion conjunctivitis 29.9 CD79A MRAP
3 bladder diverticulum 29.8 CD40LG CD79A
4 urethral syndrome 12.4
5 urethral stricture 12.3
6 posterior urethral valves 12.3
7 urethral diverticulum 12.2
8 urethral cancer 12.1
9 urethral calculus 11.9
10 urethral obstruction sequence 11.9
11 female urethral cancer 11.8
12 urethral false passage 11.8
13 urethral gland abscess 11.8
14 anterior urethral valve 11.8
15 male urethral cancer 11.8
16 urethral benign neoplasm 11.8
17 cervical ribs, sprengel anomaly, anal atresia, and urethral obstruction 11.7
18 penile urethral cancer 11.6
19 urethral villous adenoma 11.6
20 bulbomembranous urethral cancer 11.6
21 urethral intrinsic sphincter deficiency 11.6
22 prostatic urethral cancer 11.6
23 infective urethral stricture 11.6
24 urethral urothelial papilloma 11.6
25 urethral verrucous carcinoma 11.6
26 duplication of urethra 11.5
27 hypospadias 11.4
28 fowler's syndrome 11.1
29 cervicitis 11.1
30 reactive arthritis 11.1
31 hypospadias 1, x-linked 11.0
32 vacterl association, x-linked 10.9
33 congenital anomalies of kidney and urinary tract 10.9
34 testicular regression syndrome 10.7
35 mucoepithelial dysplasia, hereditary 10.7
36 congenital anomalies of kidney and urinary tract 2 10.7
37 pigmentary disorder, reticulate, with systemic manifestations, x-linked 10.7
38 otopalatodigital syndrome, type ii 10.7
39 hypospadias 2, x-linked 10.7
40 transient retinal arterial occlusion 10.7 HSPD1 MRAP
41 urethra squamous cell carcinoma 10.7
42 anterior urethra cancer 10.7
43 urethra transitional cell carcinoma 10.7
44 atresia of urethra 10.7
45 posterior urethra cancer 10.7
46 fibroepithelial polyp of urethra 10.7
47 tick-borne relapsing fever 10.6 MRAP PHB2
48 queensland tick typhus 10.6 HSPD1 MRAP
49 acute maxillary sinusitis 10.6 MRAP PHB2
50 urticaria 10.6 MRAP PHB2

Comorbidity relations with Urethritis via Phenotypic Disease Network (PDN):


Acute Cystitis Bladder Neck Obstruction
Cystitis Prostate Cancer
Prostatic Hypertrophy Trigonitis
Urethral Stricture

Graphical network of the top 20 diseases related to Urethritis:



Diseases related to Urethritis

Symptoms & Phenotypes for Urethritis

Drugs & Therapeutics for Urethritis

Drugs for Urethritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azithromycin Approved Phase 4,Phase 3,Phase 2 83905-01-5 55185 53477736 447043
2
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 564-25-0 54671203
3
Lymecycline Approved Phase 4 992-21-2 5280963
4
Tetracycline Approved, Vet_approved Phase 4 60-54-8 5353990
5 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2
6 Antibiotics, Antitubercular Phase 4,Phase 3
7 Anti-Infective Agents Phase 4,Phase 3,Phase 2
8 Antimalarials Phase 4,Phase 3,Phase 2
9 Antiparasitic Agents Phase 4,Phase 3,Phase 2
10 Antiprotozoal Agents Phase 4,Phase 3,Phase 2
11
Tinidazole Approved, Investigational Phase 2 19387-91-8 5479
12 Alkylating Agents Phase 2
13 Amdinocillin Pivoxil Phase 2
14 Renal Agents Phase 2
15
Ceftriaxone Approved 73384-59-5 5479530 5361919

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Time to Eradication of Mycoplasma Genitalium and Chlamydia Trachomatis After Treatment Commenced Unknown status NCT01661985 Phase 4 Azithromycin;Doxycycline;lymecycline
2 Mycoplasma Genitalium Antibiotic Susceptibility and Treatment (MEGA) Completed NCT00358462 Phase 3 Azithromycin;Doxycycline
3 NGU: Doxycycline (Plus or Minus Tinidazole) Versus Azithromycin (Plus or Minus Tinidazole) Completed NCT00322465 Phase 2 Tinidazole;Doxycycline;Azithromycin
4 Study to Improve Partner Services for STD Prevention Completed NCT00207467 Phase 2
5 Trial to Assess the Efficacy of F598 in Preventing an Experimental Urethral Infection With N. Gonorrhoeae in Healthy Males Not yet recruiting NCT03222401 Phase 2 1 mg/kg single infusion of F598;3 mg/kg single infusion of F598;10 mg/kg single infusion of F598
6 Mecillinam for Treatment of Genital Chlamydia Infection Terminated NCT02083276 Phase 2 Pivmecillinamhydrochlorid
7 Antimicrobial Susceptibility Patterns of N. Gonorrhea Isolates in an Era of Quinolone Resistance Completed NCT00692822
8 Chlamydia Trachomatis Immunology and Vaccinology Study Completed NCT01150747 ceftriaxone;Azithromycin
9 Chronic Inflammatory Condition of the Male Genital Tract Active, not recruiting NCT01732172
10 Combined Spinal Epidural Urinary Retention Terminated NCT01597791

Search NIH Clinical Center for Urethritis

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: urethritis

Genetic Tests for Urethritis

Anatomical Context for Urethritis

MalaCards organs/tissues related to Urethritis:

39
Prostate, Testes, Kidney, Skin, Spinal Cord, Colon, Pancreas

Publications for Urethritis

Articles related to Urethritis:

(show top 50) (show all 2942)
id Title Authors Year
1
Incidence and predictors of complications due to urethral stricture in patients awaiting urethroplasty. ( 28899769 )
2017
2
Substitution urethroplasty using oral mucosa graft for male anterior urethral stricture disease: Current topics and reviews. ( 28600871 )
2017
3
Should Female Partners of Men With Non-Gonococcal Urethritis, Negative for Chlamydia trachomatis and Mycoplasma genitalium, Be Informed and Treated? Clinical Outcomes From a Partner Study of Heterosexual Men With NGU. ( 28079749 )
2017
4
Incidence and Management of Lower Urinary Tract Symptoms After Urethral Stricture Repair. ( 28718163 )
2017
5
Re: Incidence of Urethral Stricture in Patients with Spinal Cord Injury Treated with Clean Intermittent Self-Catheterization. ( 28905775 )
2017
6
Role of urodynamics in management of urethral diverticulum in females. ( 28807625 )
2017
7
The Prostate in Female? Clear Cell Adenocarcinoma in a Female Urethral Diverticulum. ( 27789300 )
2017
8
Neisseria meningitidis ST11 Complex Isolates Associated with Nongonococcal Urethritis, Indiana, USA, 2015-2016. ( 28098538 )
2017
9
Predicting postnatal renal function of prenatally detected posterior urethral valves using fetal diffusion-weighted magnetic resonance imaging with apparent diffusion coefficient determination. ( 28453880 )
2017
10
Neisseria gonorrhoeae DNA bacterial load in men with symptomatic and asymptomatic gonococcal urethritis. ( 28148678 )
2017
11
Anastomotic Urethroplasty for an Obstructing Calculus Within a Bulbar Urethral Diverticulum and Urethral Stricture. ( 27981035 )
2017
12
Genital lichen sclerosus developing around 'ectopic' urethral orifices supports the role of occlusion and urine in its pathogenesis. ( 28081682 )
2017
13
Prevalence of Mycoplasma genitalium and other sexually transmitted infections causing urethritis among high-risk heterosexual male patients in Estonia. ( 28868962 )
2017
14
'Haemophilus quentini' in the urethra of men complaining of urethritis symptoms. ( 28889986 )
2017
15
Treatment outcomes and loss to follow-up rate of male patients with gonococcal and nongonococcal urethritis who attended the sexually transmitted disease clinic: An 8-year retrospective study. ( 28442801 )
2017
16
A complicated urethrovaginal fistula following an inappropriate urethral diverticulum management. ( 28805613 )
2017
17
Antimicrobial susceptibility of Haemophilus influenzae strains isolated from the urethra of men with acute urethritis and/or epididymitis. ( 28619239 )
2017
18
Ventral-onlay buccal mucosa graft substitution urethroplasty for urethral stricture in women. ( 28749039 )
2017
19
Initial experience with Alliuma8c stent in the management of bulbar urethral stricture. ( 28791227 )
2017
20
Genomic characterization of urethritis-associated Neisseria meningitidis shows that a wide range of N. meningitidis strains can cause urethritis. ( 28904187 )
2017
21
A rare presentation of alkaptonuria: Extensive prostatic calculi with highlight of stones found in a unique paraprostatic urethral diverticulum. ( 28779694 )
2017
22
Management of bladder neck stenosis and urethral stricture and stenosis following treatment for prostate cancer. ( 28791228 )
2017
23
Cost-effective Strategies for the Management and Treatment of Urethral Stricture Disease. ( 27908365 )
2017
24
Management of Urethral Stricture and Bladder Neck Contracture Following Primary and Salvage Treatment of Prostate Cancer. ( 28776126 )
2017
25
The predictive value of platelet to lymphocyte and neutrophil to lymphocyte ratio in determining urethral stricture after transurethral resection of prostate. ( 28861306 )
2017
26
Histological and Biochemical Evaluation of Urethral Scar following Three Different Hypospadias Repairs: An Experimental Study in Rabbits. ( 28838000 )
2017
27
A Preclinical Study of Cell-seeded Tubularized Scaffolds Specially Secreting LL37 for Reconstruction of Long Urethral Defects. ( 28739721 )
2017
28
Low Prevalence of Urethral Lymphogranuloma Venereum Infections Among Men Who Have Sex With Men: A Prospective Observational Study, Sexually Transmitted Infection Clinic in Amsterdam, the Netherlands. ( 28809772 )
2017
29
A new modification of the Duckett technique for one-stage repairing urethral plate transected hypospadias: Another option for severe hypospadias? ( 28917023 )
2017
30
The Diagnosis of Nongonococcal Urethritis in Men: Can There Be a Universal Standard? ( 28178119 )
2017
31
Fulfilling Patient Expectations of Urethral Stricture Surgery. ( 28822234 )
2017
32
Re: Analysis of Risk Factors Leading to Postoperative Urethral Stricture and Bladder Neck Contracture following Transurethral Resection of Prostate. ( 28905747 )
2017
33
Macrolide and quinolone-resistant Mycoplasma genitalium in a man with persistent urethritis: the tip of the British iceberg? ( 28438948 )
2017
34
Definition of Successful Treatment and Optimal Follow-up after Urethral Reconstruction for Urethral Stricture Disease. ( 27908363 )
2017
35
Diagnosis of urethral diverticulum mimicking pelvic organ prolapse with translabial ultrasonography. ( 28666694 )
2017
36
Anterior Urethral Valve: Uncommon Association with Renal Duplicity. ( 28770138 )
2017
37
Successful outcome of macrolide-resistant Mycoplasma genitalium urethritis after spectinomycin treatment: a case report. ( 27707988 )
2017
38
Re: Cultural background, non-therapeutic circumcision and the risk of meatal stenosis and other urethral stricture disease: Two nationwide register-based cohort studies in Denmark 1977-2013. ( 28869139 )
2017
39
Editorial Comment to Substitution urethroplasty using oral mucosa graft for male anterior urethral stricture disease: Current topics and reviews. ( 28626935 )
2017
40
Syndrome of Inappropriate Secretion of Antidiuretic Hormone Caused by Carboplatin After Switching from Cisplatin in a Metastatic Urethral Cancer Patient. ( 28271051 )
2017
41
Aggressive diagnosis and treatment for posterior urethral valve as an etiology for vesicoureteral reflux or urge incontinence in children. ( 28612060 )
2017
42
Re: Outpatient Ultrasound Urethrogram for Assessment of Anterior Urethral Stricture: Early Experience. ( 27979534 )
2017
43
Comparison of Diagnostic Value of Sonourethrography with Retrograde Urethrography in Diagnosis of Anterior Urethral Stricture. ( 28698753 )
2017
44
Clinical courses of herpes simplex virus-induced urethritis in men. ( 28412134 )
2017
45
Squamous Cell Carcinoma Penis in a Case of Urethral Stricture Due to Lichen Sclerosus Balanitis Xerotica Obliterans: A Case Report and Review of Literature. ( 28892974 )
2017
46
Clinical Characteristics of Herpes Simplex Virus Urethritis Compared With Chlamydial Urethritis Among Men. ( 28079748 )
2017
47
Haemophilus influenzae Isolated From Men With Acute Urethritis: Its Pathogenic Roles, Responses to Antimicrobial Chemotherapies, and Antimicrobial Susceptibilities. ( 28282645 )
2017
48
Female Urethral Diverticulum Carcinoma: A Case Report and Literature Review. ( 28630778 )
2017
49
Three-Dimensional Computerized Model Based on the Sonourethrogram: A Novel Technique for Evaluating the Anterior Urethral Stricture. ( 28866465 )
2017
50
Comment on "Predicting postnatal renal function of prenatally detected posterior urethral valves using fetal diffusion-weighted magnetic resonance imaging with apparent diffusion coefficient determination". ( 28777461 )
2017

Variations for Urethritis

Expression for Urethritis

Search GEO for disease gene expression data for Urethritis.

Pathways for Urethritis

Pathways related to Urethritis according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.19 CD40LG CD79A

GO Terms for Urethritis

Biological processes related to Urethritis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.43 HSPD1 TLR6
2 negative regulation of apoptotic process GO:0043066 9.43 CD40LG HSPD1 PHB2
3 B cell activation GO:0042113 9.4 CD79A HSPD1
4 positive regulation of interleukin-12 production GO:0032735 9.37 CD40LG HSPD1
5 positive regulation of interleukin-10 production GO:0032733 9.32 CD40LG HSPD1
6 mitochondrial calcium ion transport GO:0006851 9.16 PHB2 YME1L1
7 B cell proliferation GO:0042100 8.8 CD40LG CD79A HSPD1
8 positive regulation of macrophage activation GO:0043032 8.65 HSPD1

Sources for Urethritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....