MCID: URN003
MIFTS: 50

Urinary Schistosomiasis

Categories: Blood diseases, Nephrological diseases, Infectious diseases

Aliases & Classifications for Urinary Schistosomiasis

MalaCards integrated aliases for Urinary Schistosomiasis:

Name: Urinary Schistosomiasis 12 14 69
Schistosoma Hematobium Infection 12 69
Schistosomiasis Due to Schistosoma Haematobium 12
Schistosoma Hematobium Infectious Disease 12
Schistosoma Haematobium Infection 12
Cystitis with Bilharziasis 12
Schistosomiasis of Bladder 12
Schistosomiasis Haematobia 41
Bladder Schistosomiasis 12
Schistosoma Haematobium 12
Vesical Schistosomiasis 12
Schistosomiasis Urinary 51

Classifications:



External Ids:

Disease Ontology 12 DOID:1394
ICD9CM 34 120.0
MeSH 41 D012553

Summaries for Urinary Schistosomiasis

Disease Ontology : 12 A schistosomiasis that involves parasitic infection of the urinary tract caused by a digenetic trematode Schistosoma haematobium causing cystitis, ureteritis, fibrosis of the bladder and haematuria, which can progress to bladder cancer.

MalaCards based summary : Urinary Schistosomiasis, also known as schistosoma hematobium infection, is related to schistosomiasis and parasitic helminthiasis infectious disease. An important gene associated with Urinary Schistosomiasis is RNASE3 (Ribonuclease A Family Member 3), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Albendazole and Artemether have been mentioned in the context of this disorder. Affiliated tissues include testes, kidney and neutrophil, and related phenotypes are hematopoietic system and immune system

Related Diseases for Urinary Schistosomiasis

Diseases related to Urinary Schistosomiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 173)
# Related Disease Score Top Affiliating Genes
1 schistosomiasis 30.7 IFNG IL13 IL4 IL5 RNASE3 STAT6
2 parasitic helminthiasis infectious disease 29.2 IL13 IL4 IL5 RNASE3
3 onchocerciasis 28.8 EPX IL13 IL4 IL5 RNASE3
4 malaria 28.2 CTLA4 HP IFNG IL13 IL4 IL5
5 neuroschistosomiasis 11.6
6 schistosoma mansoni infection, susceptibility/ 11.3
7 loeffler endocarditis 10.4 IL5 RNASE3
8 cow milk allergy 10.4 IL5 RNASE3
9 chronic eosinophilic pneumonia 10.4 IL5 RNASE3
10 blepharoconjunctivitis 10.4 IL4 RNASE3
11 status asthmaticus 10.4 IL5 RNASE3
12 egg allergy 10.4 IL4 IL5
13 trichinosis 10.4 IL4 IL5
14 non-suppurative otitis media 10.4 IL4 IL5
15 scleritis 10.4 IL4 IL5
16 sinusitis 10.4 IL5 RNASE3
17 eosinophilic fasciitis 10.4 IFNG IL5
18 cellulitis 10.4 IL5 RNASE3
19 mycoplasmal pneumonia 10.4 IFNG IL4
20 cercarial dermatitis 10.4 IL4 IL5
21 hyperlucent lung 10.4 IFNG IL4
22 eosinophilia-myalgia syndrome 10.4 IFNG IL5
23 b-cell growth factor 10.4 IFNG IL4
24 ascaris lumbricoides infection 10.4 IFNG IL5
25 baylisascariasis 10.3 IFNG IL4
26 wells syndrome 10.3 IL5 RNASE3
27 hyper ige syndrome 10.3 IFNG IL4
28 multicentric castleman disease 10.3 IFNG IL5
29 orofacial granulomatosis 10.3 IFNG IL4
30 buruli ulcer 10.3 IFNG IL4
31 microscopic colitis 10.3 IFNG IL4
32 poliomyelitis 10.3 IFNG IL4
33 cytokine deficiency 10.3 IL13 IL5
34 primary systemic mycosis 10.3 IFNG IL4
35 churg-strauss syndrome 10.3 IL5 RNASE3
36 vulvovaginal candidiasis 10.3 IFNG IL4
37 angioimmunoblastic lymphadenopathy with dysproteinemia 10.3 IL13 IL5
38 respiratory syncytial virus infectious disease 10.3 IL13 IL5
39 coccidiosis 10.3 IFNG IL4
40 eales disease 10.3 IFNG IL4
41 lichen disease 10.3 IFNG IL4
42 jak3-deficient severe combined immunodeficiency 10.3 IL4 STAT6
43 night blindness, congenital stationary, type 1a 10.3 IL13 IL5
44 proliferative glomerulonephritis 10.2 IFNG IL4
45 radiation cystitis 10.2 IL13 IL5
46 african tick-bite fever 10.2 IFNG IL13
47 eosinophilic granuloma 10.2 EPX RNASE3
48 cryptococcosis 10.2 IFNG IL4
49 ocular cicatricial pemphigoid 10.2 IL4 RNASE3
50 radiculopathy 10.2 IL13 IL5

Graphical network of the top 20 diseases related to Urinary Schistosomiasis:



Diseases related to Urinary Schistosomiasis

Symptoms & Phenotypes for Urinary Schistosomiasis

MGI Mouse Phenotypes related to Urinary Schistosomiasis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.86 CTLA4 STAT6 EPX HP IFNG IL13
2 immune system MP:0005387 9.76 CTLA4 STAT6 EPX HP IFNG IL13
3 digestive/alimentary MP:0005381 9.72 CTLA4 IFNG IL13 IL4 IL5
4 liver/biliary system MP:0005370 9.43 CTLA4 STAT6 HP IFNG IL4 IL5
5 respiratory system MP:0005388 9.1 CTLA4 STAT6 IFNG IL13 IL4 IL5

Drugs & Therapeutics for Urinary Schistosomiasis

Drugs for Urinary Schistosomiasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 35)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Albendazole Approved, Vet_approved Phase 4 54965-21-8 2082
2
Artemether Approved Phase 4 71963-77-4 68911 119380
3
Lumefantrine Approved Phase 4 82186-77-4 6437380
4
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
5
Praziquantel Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 55268-74-1 4891
6 Anthelmintics Phase 4,Phase 3
7 Antifungal Agents Phase 4
8 Anti-Infective Agents Phase 4,Phase 3,Phase 2
9 Antimalarials Phase 4,Phase 2
10 Antimitotic Agents Phase 4
11 Antiparasitic Agents Phase 4,Phase 3,Phase 2
12 Antiprotozoal Agents Phase 4,Phase 2
13 Artemether-lumefantrine combination Phase 4
14 Artemisinine Phase 4
15 Artemisinins Phase 4
16 Vaccines Phase 3,Phase 2,Phase 1
17
Mefloquine Approved, Investigational Phase 2 53230-10-7 4046
18
Pyrimethamine Approved, Investigational, Vet_approved Phase 2 58-14-0 4993
19
Sulfadoxine Approved, Investigational Phase 2 2447-57-6 17134
20 Fanasil, pyrimethamine drug combination Phase 2
21 Pharmaceutical Solutions Phase 2
22
Aluminum hydroxide Approved, Investigational Phase 1 21645-51-2
23
Aluminum sulfate Approved Phase 1 10043-01-3
24 Adjuvants, Immunologic Phase 1
25 Antacids Phase 1
26 Antibodies Phase 1
27 Anti-Ulcer Agents Phase 1
28 Gastrointestinal Agents Phase 1
29 Immunoglobulins Phase 1
30
Azithromycin Approved 83905-01-5 53477736 447043 55185
31
Cefuroxime Approved 55268-75-2 5479529 5361202
32
Ciprofloxacin Approved, Investigational 85721-33-1 2764
33
Doxycycline Approved, Investigational, Vet_approved 564-25-0 54671203
34
Metronidazole Approved 443-48-1 4173
35 cefuroxime axetil

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Artemisinin-based Combination Therapy-Intermittent Preventive Treatment (ACT-IPT) Trial Among Schoolchildren in Kassena-Nankana, Ghana Unknown status NCT01459146 Phase 4 Artemether-lumefantrine combination plus albendazole;Artemether-lumefantrine plus Praziquantel plus Albendazole;Albendazole plus Praziquantel
2 Efficacy of Bilhvax in Association With Praziquantel for Prevention of Clinical Recurrences of Schistosoma Haematobium Completed NCT00870649 Phase 3
3 Activity of Mefloquine Against Urinary Schistosomiasis Completed NCT01132248 Phase 2 Mefloquine;S/P
4 Study of Safety and Immune Response of the Sm14 Vaccine in Adults of Endemic Regions Completed NCT03041766 Phase 2 GLA-SE solution
5 Clinical Trial of Bilhvax,a Vaccine Candidate Against Schistosomiasis Completed NCT01512277 Phase 1
6 Urogenital Schistosomiasis and Sexually Transmitted Infections in Madagascar Completed NCT00713999 Treatment with anti-STI and anti-schistosoma regimens
7 Urinary Schistosomiasis Infection Completed NCT00138450
8 Health Benefits of Repeated Treatment in Pediatric Schistosomiasis Completed NCT01424410
9 Prevention of Female Genital Schistosomiasis (FGS) in Rural High-endemic South Africa Recruiting NCT01154907 Praziquantel
10 Childhood Schistosomiasis: a Novel Strategy Extending the Benefits/Reach of Antihelminthic Treatment Active, not recruiting NCT02495909

Search NIH Clinical Center for Urinary Schistosomiasis

Cochrane evidence based reviews: schistosomiasis haematobia

Genetic Tests for Urinary Schistosomiasis

Anatomical Context for Urinary Schistosomiasis

MalaCards organs/tissues related to Urinary Schistosomiasis:

38
Testes, Kidney, Neutrophil, Skin, Colon

Publications for Urinary Schistosomiasis

Articles related to Urinary Schistosomiasis:

(show top 50) (show all 361)
# Title Authors Year
1
A comparative study on the efficacy of praziquantel and albendazole in the treatment of urinary schistosomiasis in Adim, Cross River State, Nigeria. ( 28911129 )
2017
2
Prevalence of Urinary Schistosomiasis in Migrants in Apulia, a Region of Southern Italy, in the Years 2006-2016. ( 29435460 )
2017
3
Epidemiology of Urinary Schistosomiasis among School Children in the Alsaial Alsagair Village, River Nile State, Sudan. ( 28761490 )
2017
4
Urinary schistosomiasis in school aged children of two rural endemic communities in Edo State, Nigeria. ( 28970097 )
2017
5
Using the hierarchical ordinal regression model to analyse the intensity of urinary schistosomiasis infection in school children in Lusaka Province, Zambia. ( 28219411 )
2017
6
Urinary schistosomiasis:<i>Schistosoma haematobium</i>infection diagnosed by histopathology. ( 29323093 )
2017
7
Rapid mapping of urinary schistosomiasis: An appraisal of the diagnostic efficacy of some questionnaire-based indices among high school students in Katsina State, northwestern Nigeria. ( 28369090 )
2017
8
Urinary schistosomiasis among vulnerable children in a rehabilitation home in Ibadan, Oyo state, Nigeria. ( 28693436 )
2017
9
Urinary schistosomiasis in school children of a southern nigerian community 8 years after the provision of potable water. ( 29355157 )
2017
10
Prevalence and intensity of genito-urinary schistosomiasis and associated risk factors among junior high school students in two local government areas around Zobe Dam in Katsina State, Nigeria. ( 27388007 )
2016
11
Incidental pseudolymphomatous bladder inflammatory polyp revealing urinary schistosomiasis. ( 27810520 )
2016
12
Circulating cathodic antigen cassette test versus haematuria strip test in diagnosis of urinary schistosomiasis. ( 27876913 )
2016
13
Urinary Schistosomiasis among Children in Murbai and Surbai Communities of Ardo-Kola Local Government Area, Taraba State, Nigeria. ( 28096819 )
2016
14
Urinary schistosomiasis among preschool children in Malengachanzi, Nkhotakota District, Malawi: Prevalence and risk factors. ( 27217911 )
2016
15
Bladder cancer and urinary Schistosomiasis in Angola. ( 26167543 )
2015
16
Urinary Schistosomiasis in an Adolescent Refugee from Africa: An Uncommon Cause of Hematuria and an Emerging Infectious Disease in Europe. ( 26335551 )
2015
17
Lectin Complement Protein Collectin 11 (CL-K1) and Susceptibility to Urinary Schistosomiasis. ( 25807310 )
2015
18
Immunolocalization of the 29 kDa Schistosoma haematobium species-specific antigen: a potential diagnostic marker for urinary schistosomiasis. ( 25927905 )
2015
19
Prevalence of urinary schistosomiasis and associated risk factors among Abobo Primary School children in Gambella Regional State, southwestern Ethiopia: a cross sectional study. ( 25886292 )
2015
20
High levels of urinary schistosomiasis among children in Bunuso, a rural community in Ghana: an urgent call for increased surveillance and control programs. ( 26688622 )
2015
21
Salmonella Typhi meningitis in a 9-year old boy with urinary schistosomiasis: a case report. ( 25889776 )
2015
22
Efficacy of praziquantel against urinary schistosomiasis and reinfection in Senegalese school children where there is a single well-defined transmission period. ( 26156522 )
2015
23
Prevalence and intensity of urinary schistosomiasis among school children in the district of Niakhar, region of Fatick, Senegal. ( 24387599 )
2014
24
Drugs for treating urinary schistosomiasis. ( 25099517 )
2014
25
Prevalence, intensity of infection and risk factors of urinary schistosomiasis in pre-school and school aged children in Guma Local Government Area, Nigeria. ( 24418080 )
2014
26
The effect of hookworm infection and urinary schistosomiasis on blood hemoglobin concentration of schoolchildren living in northern Mozambique. ( 24879000 )
2014
27
The unacknowledged impact of urinary schistosomiasis in children: 5 cases from Kumasi, Ghana. ( 25709140 )
2014
28
Clinical efficacy and tolerability of praziquantel for intestinal and urinary schistosomiasis-a meta-analysis of comparative and non-comparative clinical trials. ( 25412105 )
2014
29
Urinary schistosomiasis. ( 24469437 )
2014
30
Bacteriuria and urinary schistosomiasis in primary school children in rural communities in Enugu State, Nigeria, 2012. ( 25328634 )
2014
31
Urinary schistosomiasis: review. ( 25685452 )
2013
32
Urinary schistosomiasis among schoolchildren in Yemen: prevalence, risk factors, and the effect of a chemotherapeutic intervention. ( 24374945 )
2013
33
Prevalence of Urinary Schistosomiasis among School Children in a Rural Community in South-South, Nigeria. ( 23913499 )
2013
34
Spatial distribution of urinary schistosomiasis in Cross River State, Nigeria using geographical information system and school based questionnaire. ( 24506017 )
2013
35
Ultrasound findings in urinary schistosomiasis infection in school children in Gezira State, Central Sudan. ( 24231496 )
2013
36
Urinary schistosomiasis in asylum seekers in Italy: an emergency currently undervalued. ( 23135629 )
2013
37
Urinary schistosomiasis and malaria associated anemia in Ethiopia. ( 23620856 )
2013
38
A rare case of urinary schistosomiasis in Turkey. ( 24280295 )
2013
39
Urinary schistosomiasis in urban and semi-urban communities in South-eastern Nigeria. ( 24454442 )
2013
40
Immunohistochemical expression of COX2 and iNOS in bladder cancer and its association with urinary schistosomiasis among Sudanese patients. ( 23414519 )
2013
41
A pilot study on cytotoxic T lymphocyte-4 gene polymorphisms in urinary schistosomiasis. ( 22288822 )
2012
42
Urinary schistosomiasis in children in the United Kingdom. ( 22209502 )
2012
43
Pathognomonic radiological findings of chronic urinary schistosomiasis. ( 22863226 )
2012
44
Comparative analysis of urinary schistosomiasis among primary school children and rural farmers in Obollo-Eke, Enugu State, Nigeria: implications for control. ( 23043919 )
2012
45
Urinary schistosomiasis among pregnant women in some endemic tropical semi - urban communities of Anambra State, Nigeria. ( 23202602 )
2012
46
Safety and immunogenicity of rSh28GST antigen in humans: phase 1 randomized clinical study of a vaccine candidate against urinary schistosomiasis. ( 22802974 )
2012
47
Urinary schistosomiasis with simultaneous bladder squamous cell carcinoma and transitional cell carcinoma. ( 23109968 )
2012
48
Prevalence of urinary schistosomiasis in school-aged children in Langai, Plateau State: pre- and post-intervention. ( 23311180 )
2012
49
The role of artesunate for the treatment of urinary schistosomiasis in schoolchildren: a systematic review and meta-analysis. ( 23265611 )
2012
50
Preparing for national school-based deworming in Kenya: the validation and large-scale distribution of school questionnaires with urinary schistosomiasis. ( 21767334 )
2011

Variations for Urinary Schistosomiasis

Expression for Urinary Schistosomiasis

Search GEO for disease gene expression data for Urinary Schistosomiasis.

Pathways for Urinary Schistosomiasis

Pathways related to Urinary Schistosomiasis according to GeneCards Suite gene sharing:

(show all 29)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.76 CTLA4 EPX HP IFNG IL13 IL4
2
Show member pathways
13.14 IFNG IL13 IL4 IL5 STAT6
3 12.67 IFNG IL13 IL4 IL5 STAT6
4
Show member pathways
12.43 IFNG IL13 IL4 IL5 STAT6
5 12.41 CTLA4 IFNG IL4 STAT6
6
Show member pathways
12.3 CTLA4 IFNG IL4 IL5
7
Show member pathways
12.24 CTLA4 EPX IFNG IL13 IL4 IL5
8
Show member pathways
12.19 IFNG IL13 IL4 IL5
9
Show member pathways
12.15 IFNG IL13 IL4 IL5 STAT6
10
Show member pathways
12.03 IFNG IL13 IL4 IL5
11 11.86 IFNG IL4 IL5
12 11.84 IL13 IL4 STAT6
13
Show member pathways
11.83 IFNG IL4 STAT6
14 11.69 IFNG IL13 IL4 IL5
15 11.66 IFNG IL13 IL4 IL5
16
Show member pathways
11.61 CTLA4 IFNG IL4 IL5
17 11.59 CTLA4 IL4 IL5
18 11.55 IL4 IL5 STAT6
19 11.54 IL13 IL4 IL5
20 11.33 IL13 IL4
21 11.23 IFNG IL4 IL5
22 11.13 IFNG IL13 IL4 IL5
23 11.08 IFNG IL13
24 11.03 IL13 IL4 IL5
25 11.03 IFNG IL13 IL4 IL5
26 10.87 IFNG IL13 IL4 IL5
27 10.85 IL4 STAT6
28 10.68 IFNG IL13 IL4 IL5 STAT6
29 10.66 IL13 IL4 IL5

GO Terms for Urinary Schistosomiasis

Cellular components related to Urinary Schistosomiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.5 EPX HP IFNG IL13 IL4 IL5
2 extracellular space GO:0005615 9.17 EPX HP IFNG IL13 IL4 IL5

Biological processes related to Urinary Schistosomiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of receptor activity GO:0010469 9.67 IFNG IL13 IL4 IL5
2 negative regulation of endothelial cell apoptotic process GO:2000352 9.4 IL13 IL4
3 immune response GO:0006955 9.35 CTLA4 IFNG IL13 IL4 IL5
4 regulation of regulatory T cell differentiation GO:0045589 9.32 CTLA4 IFNG
5 positive regulation of isotype switching to IgE isotypes GO:0048295 9.26 IL4 STAT6
6 negative regulation of complement-dependent cytotoxicity GO:1903660 9.16 IL13 IL4
7 positive regulation of B cell proliferation GO:0030890 8.8 IL13 IL4 IL5

Molecular functions related to Urinary Schistosomiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine receptor binding GO:0005126 8.96 IL13 IL4
2 cytokine activity GO:0005125 8.92 IFNG IL13 IL4 IL5

Sources for Urinary Schistosomiasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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