MCID: URN003
MIFTS: 57

Urinary Schistosomiasis malady

Infectious diseases, Nephrological diseases, Blood diseases categories
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Summaries for Urinary Schistosomiasis

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8Disease Ontology, 33MalaCards
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Disease Ontology:8 A schistosomiasis that involves parasitic infection of the urinary tract caused by a digenetic trematode schistosoma haematobium causing cystitis, ureteritis, fibrosis of the bladder and haematuria, which can progress to bladder cancer.

MalaCards: Urinary Schistosomiasis, also known as schistosoma hematobium infection, is related to schistosomiasis and malaria. An important gene associated with Urinary Schistosomiasis is EPX (eosinophil peroxidase), and among its related pathways are IL-4 Signaling and its Primary Biological Effects in Different Immune Cell Types and IL12 signaling mediated by STAT4. The compounds ltc4 and tele-methylhistamine have been mentioned in the context of this disorder. Affiliated tissues include testes, kidney and skin, and related mouse phenotypes are tumorigenesis and liver/biliary system.

Aliases & Classifications for Urinary Schistosomiasis

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8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 40NCIt, 58SNOMED-CT, 35MeSH, 27ICD9CM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Nephrological diseases, Blood diseases


Aliases & Descriptions:

urinary schistosomiasis 8 10 62
schistosoma hematobium infection 8 62
schistosomiasis due to schistosoma haematobium 8
schistosoma hematobium infectious disease 8
vesical schistosomiasis nos 8
schistosomiasis of bladder 8
cystitis with bilharziasis 8
schistosoma haematobium 8
bladder schistosomiasis 8
schistosomiasis urinary 45


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Disease Ontology8 DOID:1394
MeSH35 D012553
ICD9CM27 120.0

Related Diseases for Urinary Schistosomiasis

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17GeneCards, 18GeneDecks
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Diseases related to Urinary Schistosomiasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 129)
idRelated DiseaseScoreTop Affiliating Genes
1schistosomiasis31.7IL13, IL10, IL5, IL4, IFNG, RNASE3
2malaria30.6IFNG, IL10
3plasmodium falciparum malaria30.5IFNG, IL10
4onchocerciasis30.4RNASE3, EPX, IL5
5atopy30.2CTLA4, IL13, IL10, IL5, IL4, IFNG
6helminthiasis30.1IGHE, RNASE3, IL5, IL13
7hepatitis b30.1IFNG, IL10, CTLA4
8hepatitis c30.0IFNG, IL4, IL10, CTLA4
9proteinuria10.5
10neuroschistosomiasis10.4
11cerebritis10.2
12intestinal schistosomiasis10.2
13bladder neck obstruction10.2
14dacryoadenitis10.2
15vaginal discharge10.2
16vaginitis10.2
17splenomegaly10.2
18epididymitis10.2
19bacteriuria10.2
20hepatitis10.2
21hypertension10.2
22eosinophilic fasciitis10.1IL5
23chronic rhinitis10.1RNASE3
24collagenous colitis10.1RNASE3
25bronchitis10.1RNASE3
26eosinophilia-myalgia syndrome10.1IL5
27aspergillosis10.1IFNG
28eosinophilic esophagitis10.1IL5
29periapical granuloma10.1IL4
30eczema herpeticum10.1IGHE
31proctitis10.1RNASE3, EPX
32thyroiditis10.1CTLA4
33chronic eosinophilic pneumonia10.1IL5, RNASE3
34conjunctivitis10.1IGHE, RNASE3
35giant papillary conjunctivitis10.1RNASE3, IL5
36churg-strauss syndrome10.1RNASE3, IL5
37trachoma10.1
38hydronephrosis10.1
39verrucous carcinoma10.1
40bladder squamous cell carcinoma10.1
41glomerulonephritis10.1
42nephrotic syndrome10.1
43transitional cell carcinoma10.1
44hepatitis c virus10.1
45blindness10.1
46anisakiasis10.1IGHE, RNASE3
47toxocariasis10.1IGHE, RNASE3
48paragonimiasis10.1IL5, IGHE
49strongyloidiasis10.1IL5, IGHE
50intraocular lymphoma10.1IL10

Graphical network of the top 20 diseases related to Urinary Schistosomiasis:



Diseases related to urinary schistosomiasis

Symptoms for Urinary Schistosomiasis

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Drugs & Therapeutics for Urinary Schistosomiasis

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Urinary Schistosomiasis

Search NIH Clinical Center for Urinary Schistosomiasis

Genetic Tests for Urinary Schistosomiasis

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Anatomical Context for Urinary Schistosomiasis

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33MalaCards
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MalaCards organs/tissues related to Urinary Schistosomiasis:

33
Testes, Kidney, Skin, Colon

Animal Models for Urinary Schistosomiasis or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Urinary Schistosomiasis:

37 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.6IL10, IL5, IFNG, STAT6
2MP:00053708.0STAT6, IFNG, IL4, IL5, IL10, CTLA4
3MP:00053817.9IFNG, IL4, IL5, IL10, IL13, CTLA4
4MP:00053797.8STAT6, IFNG, IL4, IL10, IL13, CTLA4
5MP:00107717.7STAT6, IFNG, IL4, IL10, IL13, CTLA4
6MP:00053887.6STAT6, IFNG, IL4, IL5, IL10, IL13
7MP:00053897.5STAT6, IFNG, IL4, IL5, IL10, IL13
8MP:00030127.3IGHE, IFNG, IL4, IL10, IL13, ARAP2
9MP:00053766.7IGHE, STAT6, IFNG, IL4, IL5, IL10
10MP:00053976.6CTLA4, IGHE, EPX, STAT6, IFNG, IL4
11MP:00053876.6IGHE, EPX, STAT6, IFNG, IL4, IL5

Publications for Urinary Schistosomiasis

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52PubMed
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Articles related to Urinary Schistosomiasis:

(show top 50)    (show all 329)
idTitleAuthorsYear
1
Prevalence of urinary schistosomiasis in school-aged children in Langai, Plateau State: pre- and post-intervention. (23311180)
2012
2
Proportion of Urinary Schistosomiasis among HIV-Infected Subjects in Benin City, Nigeria. (22043410)
2011
3
Urinary Schistosomiasis around Oyan Reservoir, Nigeria: Twenty Years after the First Outbreak. (23112995)
2010
4
Use of circulating cathodic antigen strips for the diagnosis of urinary schistosomiasis. (18951599)
2009
5
Evaluation of circulating cathodic antigen (CCA) strip for diagnosis of urinary schistosomiasis in Hassoba school children, Afar, Ethiopia. (18416249)
2008
6
Age and gender effects in self-reported urinary schistosomiasis in Tanzania. (18419586)
2008
7
Cystoscopy in the diagnosis and follow-up of urinary schistosomiasis in Brazilian soldiers returning from Mozambique, Africa. (16547578)
2006
8
Use of circulating cathodic antigen (CCA) dipsticks for detection of intestinal and urinary schistosomiasis. (16386231)
2006
9
Applicability of a monoclonal antibody-based dipstick in diagnosis of urinary schistosomiasis in the Central Region of Ghana. (15361112)
2004
10
Urinary schistosomiasis in Zimbabwean school children: predictors of morbidity. (15477190)
2004
11
Diagnosis of urinary schistosomiasis: a novel approach to compare bladder pathology measured by ultrasound and three methods for hematuria detection. (15238697)
2004
12
Efficacy of artesunate in the treatment of urinary schistosomiasis, in an endemic community in Nigeria. (15257799)
2004
13
Urinary schistosomiasis in schoolchildren on Zanzibar Island (Unguja), Tanzania: a parasitological survey supplemented with questionnaires. (12474477)
2002
14
Prevalence and morbidity of urinary schistosomiasis among schoolchildren in the Mwera division of Pangani district, Tanzania, 30 months after the last round of annual, selective treatments. (12625941)
2002
15
Prevalence and intensity of urinary schistosomiasis in primary school children of the Kotto Barombi Health Area, Cameroon. (12002103)
2001
16
Impact of urinary schistosomiasis on rural land use: empirical evidence from Nigeria. (11144785)
2001
17
Urinary schistosomiasis in schoolchildren in Dar-es-Salaam, Tanzania, and the factors influencing its transmission. (11784423)
2001
18
Recent urban growth and urinary schistosomiasis in Niamey, Niger. (10929143)
2000
19
Urinary schistosomiasis among schoolchildren in Ibadan, an urban community in south-western Nigeria. (10320657)
1999
20
A monoclonal antibody-based dipstick assay for diagnosis of urinary schistosomiasis. (9463666)
1997
21
The use of questionnaires for the identification of high risk areas for urinary schistosomiasis: the Ethiopian experience. (8840611)
1996
22
Urinary schistosomiasis in rural communities of some local government areas in Plateau State, Nigeria: a preliminary parasitological and malacological survey. (8960195)
1996
23
Limited field evaluation of a rapid monoclonal antibody-based dipstick assay for urinary schistosomiasis. (8985756)
1996
24
Identification and characterization of Schistosoma mansoni antigens recognized by T and B lymphocytes of humans with early active intestinal and/or urinary schistosomiasis. (7541026)
1995
25
Prevalence and severity of urinary schistosomiasis in Ibadan, Nigeria. (8904071)
1995
26
Urinary schistosomiasis in Nebraska. (7566250)
1995
27
Urinary schistosomiasis in childhood. (8073544)
1994
28
Egg viability in urinary schistosomiasis. II. Simplifying modifications and standardization of new methods. (7681485)
1993
29
Egg viability in urinary schistosomiasis. I. New methods compared with available methods. (7679149)
1993
30
Urinary schistosomiasis in the Sichili Health Zone, Western Province, Zambia. (1801143)
1991
31
Metrifonate in the control of urinary schistosomiasis in Zanzibar. (2127381)
1990
32
To wash or not to wash (Nytrel filters and urinary Schistosomiasis). (15463042)
1988
33
Efficacy of metrifonate in a highly endemic area of urinary schistosomiasis in Kenya. (3124647)
1988
34
Chronic urinary schistosomiasis: patterns of abnormalities in radionuclide Tc-99 m DTPA diuretic renogram. (3140850)
1988
35
Urinalysis reagent strips in the screening of children for urinary schistosomiasis in the RSA. (3116682)
1987
36
Ultrasonographical aspects of urinary schistosomiasis: assessment of morphological lesions in the upper and lower urinary tract. (3085056)
1986
37
Urinary schistosomiasis acquired in Mali, West Africa. I. Case report of Schistosoma haematobium infection in a Sri Lankan with a note on the parasitic life cycle and the risk of local transmission. (3109751)
1986
38
Effect of praziquantel on hematuria and proteinuria in urinary schistosomiasis. (3938926)
1985
39
Single dose oral treatment in urinary schistosomiasis: a double blind trial. (6401550)
1983
40
The effect of metrifonate on hookworm infections in Kenyan children treated for urinary schistosomiasis. A preliminary report. (6892236)
1982
41
Malumfashi Endemic Diseases Research Project, VI. Urinary schistosomiasis: abnormal urograms in infected males from the Malumfashi study area, northern Nigeria. (496461)
1979
42
Treatment of urinary schistosomiasis. (5058172)
1972
43
Manifestations of urinary schistosomiasis in a British provincial city. (5162609)
1971
44
Calcification of the bladder in urinary schistosomiasis. (5485619)
1970
45
II. Fractionation of the antigen of Fasciola gigantica by salting out with reference to the use of the isolated fractions as skin test antigens in cases of urinary schistosomiasis. (5726942)
1968
46
Steroid therapy in chronic urinary schistosomiasis (bilharziasis). (6050892)
1967
47
Urinary schistosomiasis. A case report. (5594207)
1967
48
Urinary Schistosomiasis in Ibadan school-children. (14036619)
1962
49
Urinary schistosomiasis: report of a case in a Canadian soldier. (13511306)
1958
50
The test of cure in urinary schistosomiasis. (13422576)
1957

Variations for Urinary Schistosomiasis

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Expression for genes affiliated with Urinary Schistosomiasis

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Urinary Schistosomiasis

Search GEO for disease gene expression data for Urinary Schistosomiasis.

Pathways for genes affiliated with Urinary Schistosomiasis

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50PathCards, 54R&D Systems, 38NCBI BioSystems Database, 30KEGG, 5Cell Signaling Technology, 60Thomson Reuters, 53QIAGEN, 12EMD Millipore
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Pathways related to Urinary Schistosomiasis according to GeneCards/GeneDecks:

(show all 27)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7STAT6, IL4
29.5IFNG, IL13
39.3IL10, IFNG
4
Show member pathways
9.3IL10, IFNG
59.2IL13, IL5, IL4
6
Show member pathways
Development Thrombopoetin signaling via JAK STAT pathway60
9.1IL4, IFNG, STAT6
7
Show member pathways
Immune response IL 12 induced IFN gamma production60
9.1STAT6, IFNG, IL4
8
Show member pathways
IL23-mediated signaling events38
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling38
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
9.0IL10, IFNG, STAT6
9
Show member pathways
Toll-like receptor signaling pathway38
Regulation of toll-like receptor signaling pathway38
9.0IL10, IFNG, STAT6
109.0IFNG, IL4, IL5
11
Show member pathways
Immune response IL 4 signaling pathway60
Signal transduction AKT signaling60
8.9IL4, STAT6, IGHE
12
Show member pathways
8.7IL13, IL10, IL5, IL4
13
Show member pathways
Calcium signaling in the CD4+ TCR pathway38
8.6IFNG, IL4, IL5, CTLA4
148.6IFNG, IL4, IL5, IL13
15
Show member pathways
Immune response BCR pathway60
Fc-epsilon receptor I signaling in mast cells38
8.4IGHE, IL4, IL5, IL13
16
Show member pathways
8.4STAT6, IL4, IL5, IL10, IL13
17
Show member pathways
8.4STAT6, IL4, IL5, IL10, IL13
18
Show member pathways
BCR signaling pathway38
TCR Signaling Pathway38
8.1IFNG, IL4, IL5, IL10, CTLA4
198.1IFNG, IL4, IL5, IL10, IL13
208.1IFNG, IL4, IL5, IL10, IL13
218.1IFNG, IL4, IL5, IL10, IL13
22
Show member pathways
8.1IL13, IL10, IL5, IL4, IFNG
237.9IGHE, STAT6, IL4, IL5, IL10
24
Show member pathways
7.8STAT6, IFNG, IL4, IL5, IL10, IL13
25
Show member pathways
Type III interferon signaling38
7.8STAT6, IFNG, IL4, IL5, IL10, IL13
26
Show member pathways
7.8IL13, IL10, IL5, IL4, IFNG, STAT6
27
Show member pathways
7.2CTLA4, RNASE3, EPX, IFNG, IL4, IL5

Compounds for genes affiliated with Urinary Schistosomiasis

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45Novoseek, 51PharmGKB, 29IUPHAR, 11DrugBank, 24HMDB, 61Tocris Bioscience, 3BitterDB
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Compounds related to Urinary Schistosomiasis according to GeneCards/GeneDecks:

(show top 50)    (show all 156)
idCompoundScoreTop Affiliating Genes
1ltc4459.3EPX, IL5, RNASE3, IL13
2tele-methylhistamine459.1RNASE3, EPX, IGHE
3salmeterol45 51 29 1112.1IL5, EPX, IL13, RNASE3, IL4
4sodium cromoglycate459.0RNASE3, IL5, EPX, IGHE
5cetirizine45 29 24 1112.0EPX, RNASE3, IL5, IGHE
6ketotifen45 1110.0EPX, RNASE3, IL5, IGHE
7unicap458.9IL5, RNASE3, IGHE
8betaseron458.9IFNG, IL4, IL10
9theophylline45 29 24 1111.9RNASE3, IL13, IL10, IL5, EPX
10amphotericin b458.9IL4, IL13, IL5, IFNG
11alpha-galactosylceramide458.9IFNG, IL13, IL10, IL4
12nedocromil sodium458.8IGHE, RNASE3, IL4, IL5
13indoleamine458.8IL10, IFNG, IL13, CTLA4
14omalizumab45 119.8IL4, IL5, IGHE, IL13
15ovomucoid458.8IL5, IL4, IGHE, IL13
16azelastine45 119.8RNASE3, IL4, IL5, IGHE
17pgd2458.7IL5, IGHE, RNASE3, EPX, IL13
18polyinosinic-polycytidylic acid458.6IL5, IL4, IFNG, IL10
19interferon gamma458.6IFNG, IL4, IL10
20con a458.5IL10, IL5, CTLA4, IFNG, IL4
21il-12458.5IL4, IL10, IFNG, IL5, IL13
22gm-csf45 299.5IFNG, IL13, IL10, IL4, IL5
23methacholine45 51 1110.5IGHE, RNASE3, IL13, IL4, IL5
24thalidomide45 51 61 1111.5CTLA4, IL13, IFNG, IL5, IL10
25rolipram45 61 2910.3IL13, IL4, IL5, IFNG, EPX, IL10
26salbutamol45 51 29 24 1112.2RNASE3, IGHE, IL13, EPX, IL5, IL10
27glatiramer acetate45 119.2IFNG, IL4, IL5, CTLA4, IL10, IL13
28il 10458.2IL4, IFNG, CTLA4, IL5, IL10, IL13
29tacrolimus45 51 1110.1IL10, IL5, IFNG, IL4, IL13, CTLA4
30infliximab45 51 1110.1CTLA4, IL10, IFNG, IL4, IGHE
31montelukast45 51 29 1111.0IL10, IL4, RNASE3, IGHE, IL13, IL5
32thyroxine45 249.0IL4, IL5, IL10, IL13, IGHE
33praziquantel45 119.0IL13, IL10, IL5, IL4, RNASE3, IGHE
34sb 20358045 619.0IL13, IL10, IL5, IL4, IFNG, STAT6
35ivig458.0IFNG, IGHE, IL4, IL5, IL10
36rantes457.8IL13, IL10, IL4, IFNG, CTLA4, IL5
37pge2457.8IL10, IFNG, IL4, EPX, IL5, RNASE3
38ionomycin457.8IL13, CTLA4, IL5, IFNG, IL10, IL4
39tarc457.7IL5, IL10, IL13, IFNG, IGHE, IL4
40budesonide45 51 119.7IL5, IL4, IFNG, EPX, RNASE3, IL13
41hydrocortisone45 3 61 1110.7IL5, IFNG, IL4, IL10, IGHE, IL13
42thymidine45 248.6IL5, IFNG, IL4, CTLA4, IL13, IL10
43fluticasone propionate45 51 61 1110.6IL13, IL5, IL4, RNASE3, IGHE, STAT6
44prednisolone45 29 119.6IL10, IGHE, IFNG, EPX, RNASE3, IL13
45cycloheximide457.2IL13, IL10, IL4, IFNG, STAT6, IGHE
46vegf457.1IL10, IL5, IL4, IFNG, IGHE, IL13
47cyclosporin a45 29 619.0RNASE3, IGHE, IL5, IL10, CTLA4, IL13
48histamine45 29 248.8IL5, IL4, IFNG, STAT6, EPX, RNASE3
49allergens456.5CTLA4, IL4, IFNG, IGHE, RNASE3, EPX
50dexamethasone45 51 29 119.5IL4, IL13, STAT6, EPX, RNASE3, IFNG

GO Terms for genes affiliated with Urinary Schistosomiasis

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16Gene Ontology
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Cellular components related to Urinary Schistosomiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.6CTLA4, IL13, IL4, IFNG
2extracellular regionGO:0055767.9IL13, IL5, IFNG, RNASE3, IGHE
3extracellular spaceGO:0056157.8IFNG, IL4, IL5, IL10, IL13

Biological processes related to Urinary Schistosomiasis according to GeneCards/GeneDecks:

(show all 21)
idNameGO IDScoreTop Affiliating Genes
1T-helper 1 cell lineage commitmentGO:00229610.0IL4, STAT6
2positive regulation of isotype switching to IgE isotypesGO:04829510.0STAT6, IL4
3regulation of proton transportGO:0101559.9IL13, IL4
4regulation of isotype switchingGO:0451919.8IL4, IL10
5type 2 immune responseGO:0420929.8IL10, IL4
6negative regulation of B cell proliferationGO:0308899.8IL10, CTLA4
7negative regulation of nitric oxide biosynthetic processGO:0450199.7IL10, IL4
8negative regulation of T cell proliferationGO:0421309.7IL10, CTLA4
9positive regulation of isotype switching to IgG isotypesGO:0483049.7IFNG, IL4
10positive regulation of chemokine biosynthetic processGO:0450809.6IFNG, IL4
11positive regulation of B cell proliferationGO:0308909.6IL13, IL5, IL4
12defense response to protozoanGO:0428329.5IL4, IFNG
13negative regulation of growth of symbiont in hostGO:0441309.5IFNG, IL10
14positive regulation of T cell proliferationGO:0421029.4IL4, IFNG
15positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.3IL10, IL5, IL4
16defense response to bacteriumGO:0427429.3IL10, IFNG, RNASE3
17positive regulation of MHC class II biosynthetic processGO:0453489.2IL10, IL4, IFNG
18inflammatory responseGO:0069548.9IL13, IL10, IL5
19response to drugGO:0424938.8IFNG, IL4, IL10
20positive regulation of transcription from RNA polymerase II promoterGO:0459448.6IL10, IL4, IFNG, STAT6
21immune responseGO:0069558.4IGHE, IL4, IL5, IL13, CTLA4

Molecular functions related to Urinary Schistosomiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:0080839.1IL10, IL5, IL4
2cytokine activityGO:0051257.8IL13, IL10, IL5, IL4, IFNG

Products for genes affiliated with Urinary Schistosomiasis

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Sources for Urinary Schistosomiasis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet