MCID: URN003
MIFTS: 48

Urinary Schistosomiasis malady

Categories: Infectious diseases, Nephrological diseases, Blood diseases

Aliases & Classifications for Urinary Schistosomiasis

Aliases & Descriptions for Urinary Schistosomiasis:

Name: Urinary Schistosomiasis 12 14 69
Schistosoma Hematobium Infection 12 69
Schistosomiasis Due to Schistosoma Haematobium 12
Schistosoma Hematobium Infectious Disease 12
Schistosoma Haematobium Infection 12
Cystitis with Bilharziasis 12
Schistosomiasis of Bladder 12
Schistosomiasis Haematobia 42
Bladder Schistosomiasis 12
Schistosoma Haematobium 12
Vesical Schistosomiasis 12
Schistosomiasis Urinary 52

Classifications:



External Ids:

Disease Ontology 12 DOID:1394
ICD9CM 35 120.0
MeSH 42 D012553
UMLS 69 C0276926

Summaries for Urinary Schistosomiasis

Disease Ontology : 12 A schistosomiasis that involves parasitic infection of the urinary tract caused by a digenetic trematode Schistosoma haematobium causing cystitis, ureteritis, fibrosis of the bladder and haematuria, which can progress to bladder cancer.

MalaCards based summary : Urinary Schistosomiasis, also known as schistosoma hematobium infection, is related to neuroschistosomiasis and schistosomiasis. An important gene associated with Urinary Schistosomiasis is RNASE3 (Ribonuclease A Family Member 3), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Albendazole and Artemether have been mentioned in the context of this disorder. Affiliated tissues include testes, kidney and neutrophil, and related phenotypes are hematopoietic system and immune system

Related Diseases for Urinary Schistosomiasis

Diseases related to Urinary Schistosomiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 156)
id Related Disease Score Top Affiliating Genes
1 neuroschistosomiasis 11.4
2 schistosomiasis 11.2
3 restrictive cardiomyopathy 10.3 IL5 RNASE3
4 brown shrimp allergy 10.3 IL5 RNASE3
5 latent syphilis 10.3 IL5 RNASE3
6 anterior dislocation of lens 10.3 IL4 RNASE3
7 papillary squamous carcinoma 10.2 IL4 IL5
8 gastroschisis abdominal wall defects, included 10.2 IFNG IL5
9 benign meningioma 10.2 IL5 RNASE3
10 myoglobinuria recurrent 10.2 IFNG IL4
11 infectious anterior uveitis 10.2 IL5 RNASE3
12 allescheriosis 10.2 IL4 IL5
13 asymptomatic neurosyphilis 10.2 IFNG IL4
14 albinism 10.2 IFNG IL5
15 autosomal dominant deafness-onychodystrophy syndrome 10.2 IFNG IL4
16 cataract, total congenital 10.2 IFNG IL5
17 tungiasis 10.2 IFNG IL4
18 breast intracanalicular fibroadenoma 10.2 IL4 IL5
19 hemangioma of spleen 10.2 IFNG IL5
20 amelogenesis imperfecta 1j 10.2 EPX RNASE3
21 centronuclear myopathy 5 10.2 IFNG IL4
22 histoplasmosis retinitis 10.2 IL4 IL5
23 clostridium difficile colitis 10.2 IFNG IL4
24 hypotrichosis 4 10.2 IFNG IL4
25 osteodysplasty precocious of danks mayne and kozlowski 10.2 IFNG IL4
26 appendix carcinoid tumor 10.2 EPX RNASE3
27 ovarian papillary cystadenoma 10.2 IFNG IL4
28 marasmus 10.2 IL4 IL5 RNASE3
29 lens-induced iridocyclitis 10.2 IL4 IL5 RNASE3
30 neurotic disorder 10.2 IFNG IL4
31 chemical colitis 10.2 EPX RNASE3
32 cerebral primitive neuroectodermal tumor 10.2 IL4 IL5 RNASE3
33 apricot allergy 10.1 IL4 IL5 RNASE3
34 multiple mitochondrial dysfunctions syndrome 10.1 IFNG IL5
35 orbit alveolar rhabdomyosarcoma 10.1 IL4 IL5 RNASE3
36 bile duct signet ring cell carcinoma 10.1 IL5 RNASE3
37 urethral intrinsic sphincter deficiency 10.1 IFNG IL4 IL5
38 cutaneous fibrous histiocytoma 10.1 IFNG IL4 IL5
39 hyperinsulinism due to glutamodehydrogenase deficiency 10.1 IFNG IL4
40 isolated klippel-feil syndrome 10.1 IFNG IL4 IL5
41 balkan nephropathy 10.1 IFNG IL4 IL5
42 inflammatory bowel disease 2 10.1 IFNG IL4 IL5
43 parasitic protozoa infectious disease 10.1 IFNG IL4 IL5
44 small intestine lymphoma 10.1 IL5 RNASE3
45 scalp dermatosis 10.1 EPX RNASE3
46 tularemia 10.1 IFNG IL4
47 cockayne syndrome, type b 10.1 IFNG IL4 IL5
48 necrotizing gastritis 10.1 EPX IL5 RNASE3
49 dahlberg borer newcomer syndrome 10.1 IL13 IL5
50 hypersensitivity vasculitis 10.1 IL4 IL5 STAT6

Graphical network of the top 20 diseases related to Urinary Schistosomiasis:



Diseases related to Urinary Schistosomiasis

Symptoms & Phenotypes for Urinary Schistosomiasis

MGI Mouse Phenotypes related to Urinary Schistosomiasis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.86 CTLA4 EPX HP IFNG IL13 IL4
2 immune system MP:0005387 9.76 HP IFNG IL13 IL4 IL5 STAT6
3 digestive/alimentary MP:0005381 9.72 CTLA4 IFNG IL13 IL4 IL5
4 liver/biliary system MP:0005370 9.43 CTLA4 HP IFNG IL4 IL5 STAT6
5 respiratory system MP:0005388 9.1 CTLA4 IFNG IL13 IL4 IL5 STAT6

Drugs & Therapeutics for Urinary Schistosomiasis

Drugs for Urinary Schistosomiasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 53)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Albendazole Approved, Vet_approved Phase 4,Phase 3 54965-21-8 2082
2
Artemether Approved Phase 4 71963-77-4 119380 68911
3
Lumefantrine Approved Phase 4 82186-77-4 6437380
4
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
5
Praziquantel Approved, Vet_approved Phase 4,Phase 3,Phase 2 55268-74-1 4891
6 Anthelmintics Phase 4,Phase 3,Phase 2
7 Antifungal Agents Phase 4
8 Anti-Infective Agents Phase 4,Phase 3,Phase 2
9 Antimalarials Phase 4,Phase 2,Phase 3
10 Antimitotic Agents Phase 4,Phase 3
11 Antiparasitic Agents Phase 4,Phase 3,Phase 2
12 Antiprotozoal Agents Phase 4,Phase 2,Phase 3
13 Artemether-lumefantrine combination Phase 4
14 Artemisinine Phase 4,Phase 2,Phase 3
15 Artemisinins Phase 4,Phase 2,Phase 3
16
Artesunate Approved Phase 2, Phase 3 88495-63-0 6917864 5464098
17
Pyrimethamine Approved, Vet_approved Phase 2, Phase 3 58-14-0 4993
18
Sulfadoxine Approved Phase 3,Phase 2 2447-57-6 17134
19
Myrrh Approved, Nutraceutical Phase 3 9000-45-7
20
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2, Phase 3 59-30-3 6037
21
leucovorin Approved, Nutraceutical Phase 2, Phase 3 58-05-9 54575, 6560146 143
22 Vaccines Phase 3,Phase 2,Phase 1
23 Folic Acid Antagonists Phase 2, Phase 3
24 Renal Agents Phase 2, Phase 3
25 Sulfalene Phase 2, Phase 3
26 Vitamin B Complex Phase 2, Phase 3
27 Fanasil, pyrimethamine drug combination Phase 3,Phase 2
28
Piperaquine Phase 3 4085-31-8 5079497
29 Triclabendazole Phase 3
30 Folate Nutraceutical Phase 2, Phase 3
31 Vitamin B9 Nutraceutical Phase 2, Phase 3
32
Mefloquine Approved Phase 2 53230-10-7 4046
33 Pharmaceutical Solutions Phase 2
34
Aluminum hydroxide Approved Phase 1 21645-51-2
35 Adjuvants, Immunologic Phase 1
36 Aluminum sulfate Phase 1
37 Antacids Phase 1
38 Antibodies Phase 1
39 Anti-Ulcer Agents Phase 1
40 Gastrointestinal Agents Phase 1
41 Immunoglobulins Phase 1
42
Iron Approved 7439-89-6 23925
43
Azithromycin Approved 83905-01-5 55185 53477736 447043
44
Cefuroxime Approved 55268-75-2 5361202 5479529
45
Ciprofloxacin Approved, Investigational 85721-33-1 2764
46
Doxycycline Approved, Investigational, Vet_approved 564-25-0 54671203
47
Metronidazole Approved 443-48-1 4173
48 Micronutrients
49 Trace Elements
50 cefuroxime axetil

Interventional clinical trials:

(show all 21)
id Name Status NCT ID Phase
1 Artemisinin-based Combination Therapy-Intermittent Preventive Treatment (ACT-IPT) Trial Among Schoolchildren in Kassena-Nankana, Ghana Unknown status NCT01459146 Phase 4
2 Effect of Concomitant Mansonella Perstans Microfilaremia on Immune Responses Following Single Dose Praziquantel in People With Schistosomiasis Not yet recruiting NCT02734186 Phase 4
3 Schistosoma Haematobium Infections and Praziquantel Completed NCT01558336 Phase 3
4 Safety and Efficacy of Mirazid for Schistosomiasis Treatment Completed NCT01529710 Phase 3
5 Efficacy of Bilhvax in Association With Praziquantel for Prevention of Clinical Recurrences of Schistosoma Haematobium Completed NCT00870649 Phase 3
6 Comparing Praziquantel Versus Artesunate + Sulfamethoxypyrazine/Pyrimethamine for Treating Schistosomiasis Completed NCT00510159 Phase 2, Phase 3
7 Impact IPT With Sulfadoxine-pyrimethamine or Sulfadoxine-pyrimethamine Plus Piperaquine in Schoolchildren Completed NCT01722539 Phase 3
8 The Chinese-made Praziquantel for Treatment of Schistosoma Haematobium Recruiting NCT03133832 Phase 3
9 Activity of Mefloquine Against Urinary Schistosomiasis Completed NCT01132248 Phase 2
10 An Open Label Dose Finding Safety and Efficacy in Children and Infants Infected With Schistosomiasis (S.Mansoni) Recruiting NCT02806232 Phase 2
11 Study of Safety and Immune Response of the Sm14 Vaccine in Adults of Endemic Regions Active, not recruiting NCT03041766 Phase 2
12 Clinical Trial of Bilhvax,a Vaccine Candidate Against Schistosomiasis Completed NCT01512277 Phase 1
13 Influence of Transmission Season on Outcome of Treatment of Schistosoma Haematobium Infection in Mozambique Completed NCT00231322
14 Urinary Schistosomiasis Infection Completed NCT00138450
15 Iron Absorption and Utilization in Adolescents Infected With Malaria Parasites, Hookworms or Schistosoma Completed NCT01163877
16 Urogenital Schistosomiasis and Sexually Transmitted Infections in Madagascar Completed NCT00713999
17 Schistosomiasis Effect on Response to Vaccines, Anaemia and Nutritional Status of Children of Northern Senegal Completed NCT01553552
18 Iron Supplementation in Schistosomiasis and Soil Transmitted Helminths Control Programmes in Zambia Completed NCT00276224
19 Health Benefits of Repeated Treatment in Pediatric Schistosomiasis Completed NCT01424410
20 Prevention of Female Genital Schistosomiasis (FGS) in Rural High-endemic South Africa Active, not recruiting NCT01154907
21 Childhood Schistosomiasis: a Novel Strategy Extending the Benefits/Reach of Antihelminthic Treatment Not yet recruiting NCT02495909

Search NIH Clinical Center for Urinary Schistosomiasis

Cochrane evidence based reviews: schistosomiasis haematobia

Genetic Tests for Urinary Schistosomiasis

Anatomical Context for Urinary Schistosomiasis

MalaCards organs/tissues related to Urinary Schistosomiasis:

39
Testes, Kidney, Neutrophil, Skin, Colon

Publications for Urinary Schistosomiasis

Articles related to Urinary Schistosomiasis:

(show top 50) (show all 350)
id Title Authors Year
1
Circulating cathodic antigen cassette test versus haematuria strip test in diagnosis of urinary schistosomiasis. ( 27876913 )
2016
2
Urinary schistosomiasis among preschool children in Malengachanzi, Nkhotakota District, Malawi: Prevalence and risk factors. ( 27217911 )
2016
3
Incidental pseudolymphomatous bladder inflammatory polyp revealing urinary schistosomiasis. ( 27810520 )
2016
4
Prevalence and intensity of genito-urinary schistosomiasis and associated risk factors among junior high school students in two local government areas around Zobe Dam in Katsina State, Nigeria. ( 27388007 )
2016
5
Lectin Complement Protein Collectin 11 (CL-K1) and Susceptibility to Urinary Schistosomiasis. ( 25807310 )
2015
6
Salmonella Typhi meningitis in a 9-year old boy with urinary schistosomiasis: a case report. ( 25889776 )
2015
7
Prevalence of urinary schistosomiasis and associated risk factors among Abobo Primary School children in Gambella Regional State, southwestern Ethiopia: a cross sectional study. ( 25886292 )
2015
8
Efficacy of praziquantel against urinary schistosomiasis and reinfection in Senegalese school children where there is a single well-defined transmission period. ( 26156522 )
2015
9
Bladder cancer and urinary Schistosomiasis in Angola. ( 26167543 )
2015
10
Immunolocalization of the 29 kDa Schistosoma haematobium species-specific antigen: a potential diagnostic marker for urinary schistosomiasis. ( 25927905 )
2015
11
Urinary Schistosomiasis in an Adolescent Refugee from Africa: An Uncommon Cause of Hematuria and an Emerging Infectious Disease in Europe. ( 26335551 )
2015
12
High levels of urinary schistosomiasis among children in Bunuso, a rural community in Ghana: an urgent call for increased surveillance and control programs. ( 26688622 )
2015
13
Prevalence and intensity of urinary schistosomiasis among school children in the district of Niakhar, region of Fatick, Senegal. ( 24387599 )
2014
14
Urinary schistosomiasis. ( 24469437 )
2014
15
Clinical efficacy and tolerability of praziquantel for intestinal and urinary schistosomiasis-a meta-analysis of comparative and non-comparative clinical trials. ( 25412105 )
2014
16
Drugs for treating urinary schistosomiasis. ( 25099517 )
2014
17
Bacteriuria and urinary schistosomiasis in primary school children in rural communities in Enugu State, Nigeria, 2012. ( 25328634 )
2014
18
The effect of hookworm infection and urinary schistosomiasis on blood hemoglobin concentration of schoolchildren living in northern Mozambique. ( 24879000 )
2014
19
The unacknowledged impact of urinary schistosomiasis in children: 5 cases from Kumasi, Ghana. ( 25709140 )
2014
20
Prevalence, intensity of infection and risk factors of urinary schistosomiasis in pre-school and school aged children in Guma Local Government Area, Nigeria. ( 24418080 )
2014
21
Urinary schistosomiasis and malaria associated anemia in Ethiopia. ( 23620856 )
2013
22
Urinary schistosomiasis: review. ( 25685452 )
2013
23
Ultrasound findings in urinary schistosomiasis infection in school children in Gezira State, Central Sudan. ( 24231496 )
2013
24
Urinary schistosomiasis among schoolchildren in Yemen: prevalence, risk factors, and the effect of a chemotherapeutic intervention. ( 24374945 )
2013
25
Urinary schistosomiasis in asylum seekers in Italy: an emergency currently undervalued. ( 23135629 )
2013
26
Prevalence of Urinary Schistosomiasis among School Children in a Rural Community in South-South, Nigeria. ( 23913499 )
2013
27
Urinary schistosomiasis in urban and semi-urban communities in South-eastern Nigeria. ( 24454442 )
2013
28
A rare case of urinary schistosomiasis in Turkey. ( 24280295 )
2013
29
Spatial distribution of urinary schistosomiasis in Cross River State, Nigeria using geographical information system and school based questionnaire. ( 24506017 )
2013
30
Immunohistochemical expression of COX2 and iNOS in bladder cancer and its association with urinary schistosomiasis among Sudanese patients. ( 23414519 )
2013
31
Safety and immunogenicity of rSh28GST antigen in humans: phase 1 randomized clinical study of a vaccine candidate against urinary schistosomiasis. ( 22802974 )
2012
32
Urinary schistosomiasis in children in the United Kingdom. ( 22209502 )
2012
33
Prevalence of urinary schistosomiasis in school-aged children in Langai, Plateau State: pre- and post-intervention. ( 23311180 )
2012
34
A pilot study on cytotoxic T lymphocyte-4 gene polymorphisms in urinary schistosomiasis. ( 22288822 )
2012
35
The role of artesunate for the treatment of urinary schistosomiasis in schoolchildren: a systematic review and meta-analysis. ( 23265611 )
2012
36
Urinary schistosomiasis among pregnant women in some endemic tropical semi - urban communities of Anambra State, Nigeria. ( 23202602 )
2012
37
Comparative analysis of urinary schistosomiasis among primary school children and rural farmers in Obollo-Eke, Enugu State, Nigeria: implications for control. ( 23043919 )
2012
38
Urinary schistosomiasis with simultaneous bladder squamous cell carcinoma and transitional cell carcinoma. ( 23109968 )
2012
39
Pathognomonic radiological findings of chronic urinary schistosomiasis. ( 22863226 )
2012
40
Urinary schistosomiasis among preschool-aged children in Sahelian rural communities in Mali. ( 21338486 )
2011
41
High prevalence of urinary schistosomiasis in two communities in South Darfur: implication for interventions. ( 21299881 )
2011
42
Proportion of Urinary Schistosomiasis among HIV-Infected Subjects in Benin City, Nigeria. ( 22043410 )
2011
43
Preparing for national school-based deworming in Kenya: the validation and large-scale distribution of school questionnaires with urinary schistosomiasis. ( 21767334 )
2011
44
Urinary schistosomiasis in France. ( 21524931 )
2011
45
Studies on the prevalence of urinary schistosomiasis in Ogun State, South-Western Nigeria. ( 21863592 )
2011
46
Urinary schistosomiasis among preschool children in a rural community near Abeokuta, Nigeria. ( 20602792 )
2010
47
Urinary Schistosomiasis around Oyan Reservoir, Nigeria: Twenty Years after the First Outbreak. ( 23112995 )
2010
48
Factors associated with urinary schistosomiasis in two peri-urban communities in south-western Nigeria. ( 20819309 )
2010
49
A wake up call for urinary schistosomiasis: reconciling research effort with public health importance. ( 19627633 )
2009
50
A simple approach improving the performance of urine reagent strips for rapid diagnosis of urinary schistosomiasis in Nigerian schoolchildren. ( 19547872 )
2009

Variations for Urinary Schistosomiasis

Expression for Urinary Schistosomiasis

Search GEO for disease gene expression data for Urinary Schistosomiasis.

Pathways for Urinary Schistosomiasis

Pathways related to Urinary Schistosomiasis according to GeneCards Suite gene sharing:

(show all 27)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.76 CTLA4 EPX HP IFNG IL13 IL4
2
Show member pathways
13.14 IFNG IL13 IL4 IL5 STAT6
3
Show member pathways
12.43 IFNG IL13 IL4 IL5 STAT6
4 12.39 CTLA4 IFNG IL4 STAT6
5
Show member pathways
12.29 CTLA4 IFNG IL4 IL5
6
Show member pathways
12.24 CTLA4 EPX IFNG IL13 IL4 IL5
7
Show member pathways
12.18 IFNG IL13 IL4 IL5
8
Show member pathways
12.03 IFNG IL13 IL4 IL5
9
Show member pathways
12 IFNG IL13 IL4 IL5 STAT6
10 11.86 IFNG IL4 IL5
11 11.84 IL13 IL4 STAT6
12
Show member pathways
11.83 IFNG IL4 STAT6
13 11.67 IFNG IL13 IL4 IL5
14 11.64 IFNG IL13 IL4 IL5
15 11.61 CTLA4 IL4 IL5
16
Show member pathways
11.59 CTLA4 IFNG IL4 IL5
17 11.54 IL4 IL5 STAT6
18 11.53 IL13 IL4 IL5
19 11.23 IFNG IL4 IL5
20 11.13 IFNG IL13 IL4 IL5
21 11.08 IFNG IL13
22 11.03 IL13 IL4 IL5
23 11.03 IFNG IL13 IL4 IL5
24 10.94 IL4 STAT6
25 10.87 IFNG IL13 IL4 IL5
26 10.83 IL13 IL4 IL5
27 10.69 IFNG IL13 IL4 IL5 STAT6

GO Terms for Urinary Schistosomiasis

Cellular components related to Urinary Schistosomiasis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.7 EPX HP IFNG IL13 IL4 IL5
2 external side of plasma membrane GO:0009897 9.26 CTLA4 IFNG IL13 IL4
3 extracellular space GO:0005615 9.17 EPX HP IFNG IL13 IL4 IL5

Biological processes related to Urinary Schistosomiasis according to GeneCards Suite gene sharing:

(show all 16)
id Name GO ID Score Top Affiliating Genes
1 defense response to bacterium GO:0042742 9.73 HP IFNG RNASE3
2 negative regulation of endothelial cell apoptotic process GO:2000352 9.55 IL13 IL4
3 immune response GO:0006955 9.55 CTLA4 IFNG IL13 IL4 IL5
4 innate immune response in mucosa GO:0002227 9.54 IL4 RNASE3
5 defense response to protozoan GO:0042832 9.52 IFNG IL4
6 microglial cell activation GO:0001774 9.51 IL13 IL4
7 positive regulation of chemokine biosynthetic process GO:0045080 9.49 IFNG IL4
8 positive regulation of isotype switching to IgG isotypes GO:0048304 9.48 IFNG IL4
9 positive regulation of mast cell degranulation GO:0043306 9.46 IL13 IL4
10 positive regulation of MHC class II biosynthetic process GO:0045348 9.43 IFNG IL4
11 positive regulation of immunoglobulin production GO:0002639 9.4 IL13 IL4
12 regulation of proton transport GO:0010155 9.37 IL13 IL4
13 negative regulation of complement-dependent cytotoxicity GO:1903660 9.32 IL13 IL4
14 positive regulation of isotype switching to IgE isotypes GO:0048295 9.26 IL4 STAT6
15 positive regulation of B cell proliferation GO:0030890 9.13 IL13 IL4 IL5
16 T-helper 1 cell lineage commitment GO:0002296 8.62 IL4 STAT6

Molecular functions related to Urinary Schistosomiasis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine receptor binding GO:0005126 8.96 IL13 IL4
2 cytokine activity GO:0005125 8.92 IFNG IL13 IL4 IL5

Sources for Urinary Schistosomiasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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