MCID: URN003
MIFTS: 52

Urinary Schistosomiasis malady

Nephrological, Blood categories

Summaries for Urinary Schistosomiasis

Sources:
8Disease Ontology, 33MalaCards
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Disease Ontology:8 A schistosomiasis that involves parasitic infection of the urinary tract caused by a digenetic trematode schistosoma haematobium causing cystitis, ureteritis, fibrosis of the bladder and haematuria, which can progress to bladder cancer.

MalaCards: Urinary Schistosomiasis, also known as schistosoma hematobium infection, is related to atopy and onchocerciasis. An important gene associated with Urinary Schistosomiasis is EPX (eosinophil peroxidase), and among its related pathways are PEDF Induced Signaling and IL-4 Signaling and its Primary Biological Effects in Different Immune Cell Types. The compounds rolipram and pge2 have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and kidney, and related mouse phenotypes are respiratory system and endocrine/exocrine gland.

Aliases & Classifications for Urinary Schistosomiasis

Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 45Novoseek, 57SNOMED-CT, 35MeSH, 27ICD9CM, 40NCIt
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological, Blood


Aliases & Descriptions:

urinary schistosomiasis 8 10 61
schistosoma hematobium infection 8 61
schistosomiasis due to schistosoma haematobium 8
schistosoma hematobium infectious disease 8
vesical schistosomiasis nos 8
cystitis with bilharziasis 8
schistosomiasis of bladder 8
schistosoma haematobium 8
bladder schistosomiasis 8
schistosomiasis urinary 45


External Ids:

Disease Ontology8 DOID:1394
MeSH35 D012553
ICD9CM27 120.0

Related Diseases for Urinary Schistosomiasis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Urinary Schistosomiasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 158)
idRelated DiseaseScoreTop Affiliating Genes
1atopy30.5IL4, IL5, IL10, IL13, RNASE3, EPX
2onchocerciasis30.3IL5, RNASE3, EPX
3helminthiasis30.0IGHE, RNASE3, IL13, IL5
4plasmodium falciparum malaria10.5
5neuroschistosomiasis10.4
6intestinal schistosomiasis10.4
7bladder neck obstruction10.2
8vaginal discharge10.2
9vaginal disease10.2
10splenomegaly10.2
11epididymitis10.2
12bacteriuria10.2
13bladder carcinoma10.2
14m�ni�re disease10.2
15trachoma10.1
16hydronephrosis10.1
17verrucous carcinoma10.1
18n syndrome10.1
19hepatitis a10.1
20bladder squamous cell carcinoma10.1
21bladder transitional cell carcinoma10.1
22squamous cell carcinoma10.1
23transitional cell carcinoma10.1
24cystic fibrosis10.0RNASE3
25deficiency anemia10.0EPX
26bronchopulmonary dysplasia10.0RNASE3
27nephrotic syndrome10.0IL13
28dilated cardiomyopathy10.0STAT6
29pulmonary fibrosis10.0IL13
30eosinophilic esophagitis10.0IL5
31mycosis fungoides10.0IL5
32hypothyroidism10.0CTLA4
33celiac disease10.0CTLA4
34hyperthyroidism10.0CTLA4
35eosinophilic fasciitis10.0IL5
36vasculitis10.0CTLA4
37osteoarthritis10.0CTLA4
38diabetes mellitus10.0CTLA4
39arthropathy10.0CTLA4
40chronic rhinitis10.0RNASE3
41thyroiditis10.0CTLA4
42hepatitis10.0CTLA4
43aspergillosis10.0IFNG
44vitiligo10.0CTLA4
45candidiasis10.0IFNG
46alopecia areata10.0IFNG
47aplastic anemia10.0IFNG
48toxic shock syndrome10.0IFNG
49astrocytoma10.0IL13
50collagenous colitis10.0RNASE3

Graphical network of the top 20 diseases related to Urinary Schistosomiasis:



Diseases related to urinary schistosomiasis

Clinical Features for Urinary Schistosomiasis

Drugs & Therapeutics for Urinary Schistosomiasis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Urinary Schistosomiasis

Drug clinical trials:

Search ClinicalTrials for Urinary Schistosomiasis

Search NIH Clinical Center for Urinary Schistosomiasis

Search CenterWatch for Urinary Schistosomiasis

Genetic Tests for Urinary Schistosomiasis

Anatomical Context for Urinary Schistosomiasis

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Urinary Schistosomiasis:

33
Skin, Liver, Kidney, Small intestine, Colon, T cells, B cells

Animal Models for Urinary Schistosomiasis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Urinary Schistosomiasis

Sources:
51PubMed
See all sources

Articles related to Urinary Schistosomiasis:

(show top 50)    (show all 342)
idTitleAuthorsYear
1
Immunohistochemical expression of COX2 and iNOS in bladder cancer and its association with urinary schistosomiasis among Sudanese patients. (23414519)
2013
2
Ultrasound findings in urinary schistosomiasis infection in school children in Gezira State, Central Sudan. (24231496)
2013
3
Prevalence of urinary schistosomiasis in school-aged children in Langai, Plateau State: pre- and post-intervention. (23311180)
2012
4
Urinary schistosomiasis with simultaneous bladder squamous cell carcinoma and transitional cell carcinoma. (23109968)
2012
5
Pathognomonic radiological findings of chronic urinary schistosomiasis. (22863226)
2012
6
Safety and immunogenicity of rSh28GST antigen in humans: phase 1 randomized clinical study of a vaccine candidate against urinary schistosomiasis. (22802974)
2012
7
Urinary schistosomiasis among preschool-aged children in Sahelian rural communities in Mali. (21338486)
2011
8
Factors associated with urinary schistosomiasis in two peri-urban communities in south-western Nigeria. (20819309)
2010
9
Measuring morbidity associated with urinary schistosomiasis: assessing levels of excreted urine albumin and urinary tract pathologies. (19806223)
2009
10
Evaluation of circulating cathodic antigen (CCA) strip for diagnosis of urinary schistosomiasis in Hassoba school children, Afar, Ethiopia. (18416249)
2008
11
Age and gender effects in self-reported urinary schistosomiasis in Tanzania. (18419586)
2008
12
Bayesian spatial analysis of a national urinary schistosomiasis questionnaire to assist geographic targeting of schistosomiasis control in Tanzania, East Africa. (17920605)
2008
13
School-based control of urinary schistosomiasis on Zanzibar, Tanzania: monitoring micro-haematuria with reagent strips as a rapid urological assessment. (18947774)
2007
14
Prevalence of urinary schistosomiasis and HIV in females living in a rural community of Zimbabwe: does age matter? (17064746)
2007
15
Diagnosis of urinary schistosomiasis: a novel approach to compare bladder pathology measured by ultrasound and three methods for hematuria detection. (15238697)
2004
16
Health education strategy in the control of urinary schistosomiasis. (12875488)
2003
17
Screening of Tanzanian women of childbearing age for urinary schistosomiasis: validity of urine reagent strip readings and self-reported symptoms. (10885183)
2000
18
Urinary schistosomiasis in southern Ghana: 1. Prevalence and morbidity assessment in three (defined) rural areas drained by the Densu river. (10882905)
2000
19
The transmission status of Bulinus on Zanzibar Island (Unguja), with implications for control of urinary schistosomiasis. (10723528)
2000
20
Leucocyte migration inhibitory factor assay in Nigerians with urinary schistosomiasis. (10504865)
1999
21
A cost effective two step rapid diagnosis of urinary schistosomiasis in Zimbabwe. (10028189)
1998
22
Predicting the impact of school-based treatment for urinary schistosomiasis given by the Ghana Partnership for Child Development. (9850386)
1998
23
A monoclonal antibody-based dipstick assay for diagnosis of urinary schistosomiasis. (9463666)
1997
24
Progress in urinary schistosomiasis control measures in Iran. (7714937)
1995
25
Urinary schistosomiasis in childhood. (8073544)
1994
26
Community-based questionnaires and health statistics as tools for the cost-efficient identification of communities at risk of urinary schistosomiasis. (1955266)
1991
27
Urinary schistosomiasis on Pemba Island: low-cost diagnosis for control in a primary health care setting. (15463144)
1989
28
Ultrasonographical aspects of urinary schistosomiasis: assessment of morphological lesions in the upper and lower urinary tract. (3085056)
1986
29
False epidemiological results from the bulk transport of dried filter papers in urinary schistosomiasis. (3097800)
1986
30
Influence of the dosing interval on the response of urinary schistosomiasis to therapy with niridazole. (3102208)
1986
31
Effect of praziquantel on hematuria and proteinuria in urinary schistosomiasis. (3938926)
1985
32
Endemicity of urinary schistosomiasis in Enta-doyta village, Gewane flood-plain, eastern Ethiopia. (4006923)
1985
33
Single dose oral treatment in urinary schistosomiasis: a double blind trial. (6401550)
1983
34
Urinary schistosomiasis in the Sahelian region of the Senegal River Basin. (6649050)
1983
35
Morbidity in urinary schistosomiasis in relation to the intensity of infection in Kisumu, Kenya. (6887316)
1983
36
Simultaneous use of a sensitive filtration technique and reagent strips in urinary schistosomiasis. (7112663)
1982
37
Use of metrifonate for selective population chemotherapy against urinary schistosomiasis in an endemic area at Mwanza, Tanzania. (7215272)
1981
38
Malumfashi Endemic Diseases Research Project IX. Urinary schistosomiasis and hypertension in the Malumfashi area. (496480)
1979
39
The study of the immune responses in patients with uncomplicated urinary schistosomiasis. (556281)
1978
40
Metrifonate in urinary schistosomiasis. A field trial in northern Nigeria. (1092278)
1975
41
Calcification of the bladder in urinary schistosomiasis. (5485619)
1970
42
Bacteriological and urinary findings in adolescent Egyptian males with and without urinary schistosomiasis. (4920427)
1970
43
Activity of niridazole in urinary schistosomiasis: prophylaxis and principles of control. (5259287)
1969
44
Studies on the capability of the snail transmitting urinary schistosomiasis in western Nigeria to survive dry conditions. (5700123)
1968
45
CORRELATION BETWEEN THE RESULTS OF INTRADERMAL AND COMPLEMENT FIXATION TESTS IN THE DIAGNOSIS OF URINARY SCHISTOSOMIASIS. (14347466)
1965
46
Urinary schistosomiasis: report of a case in a Canadian soldier. (13511306)
1958
47
Experiences in the treatment of urinary schistosomiasis with nilodin (miracil D). (13391909)
1956
48
Long term investigation of blood loss and egg load in urinary schistosomiasis in the adult African Bantu. (13077708)
1953
49
Urinary schistosomiasis treated with miracil D. (18124286)
1949
50
Renal concentration test in urinary schistosomiasis and the effect of tartar-emetic on it. (18873861)
1948

Genetic Variations for Urinary Schistosomiasis

Expression for genes affiliated with Urinary Schistosomiasis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Urinary Schistosomiasis

Search GEO for disease gene expression data for Urinary Schistosomiasis.

Pathways for genes affiliated with Urinary Schistosomiasis

Sources:
52QIAGEN, 30KEGG, 53R&D Systems, 4Cell Signaling Technology, 12EMD Millipore, 38NCBI BioSystems Database, 54Reactome
See all sources

Pathways related to Urinary Schistosomiasis according to GeneCards/GeneDecks:

(show all 21)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.8IL5, IL13
29.8IL4, STAT6
3
Hide members
9.5IL10, IFNG
49.4IL4, IL5, IL13
5
Development Thrombopoetin signaling via JAK-STAT pathway
Hide members
9.2IFNG, STAT6, IL4
6
Hide members
9.2IFNG, STAT6, IL4
7
Development PDGF signaling via STATs and NF-kB
Hide members
9.2IL10, STAT6, IFNG
89.2IL4, IL5, IFNG
98.9IL5, IFNG, IL13, IL4
10
Hide members
8.8IFNG, IL4, IL5, CTLA4
11
Hide members
8.6IL4, IL5, IL10, IL13, STAT6
128.4IL4, IL5, IL10, IGHE
138.4IFNG, IL13, IL10, IL5, IL4
148.4IL13, IL5, IL4, IFNG, IL10
15
Hide members
8.4IFNG, CTLA4, IL10, IL5, IL4
16
Hide members
8.1IGHE, IFNG, CTLA4, STAT6, IL5
178.1IFNG, IL13, IL10, IL5, IL4, STAT6
18
Hide members
8.1IL5, STAT6, IL13, IL10, IFNG, IL4
19
Hide members
8.1IL10, IL13, IFNG, STAT6, IL4, IL5
20
Hide members
7.7STAT6, IL4, IFNG, IL5, IL13, IGHE
21
Hide members
7.5IL5, IL4, IL10, IL13, RNASE3, EPX

Compounds for genes affiliated with Urinary Schistosomiasis

Sources:
45Novoseek, 60Tocris Bioscience, 29IUPHAR, 2BitterDB, 11DrugBank, 50PharmGKB, 24HMDB
See all sources

Compounds related to Urinary Schistosomiasis according to GeneCards/GeneDecks:

(show top 50)    (show all 134)
idCompoundScoreTop Affiliating Genes
1rolipram45 60 2912.7EPX
2pge24510.5EPX
3amphotericin b4510.4IL13
4indoleamine4510.4IL13
5hydrocortisone45 2 60 1113.0IGHE
6ovomucoid4510.0IGHE
7gm-csf45 2910.9IFNG, IL10
8rantes459.7IL4, RNASE3, IFNG
9ltc4459.5EPX, IL5, IL13, RNASE3
10salmeterol45 50 29 1112.3IL13, EPX, RNASE3, IL5, IL4
11betaseron459.3IL4, IL10, IFNG
12unicap459.2IL5, RNASE3, IGHE
13interferon gamma459.2IL4, IFNG, IL10
14alpha-galactosylceramide459.1IL10, IL4, IFNG, IL13
15tele-methylhistamine459.1EPX, RNASE3, IGHE
16sodium cromoglycate459.1IL5, RNASE3, EPX, IGHE
17cetirizine45 29 11 2412.1IGHE, EPX, RNASE3, IL5
18theophylline45 29 11 2412.1EPX, IL5, IL13, IL10, RNASE3
19ketotifen45 1110.1IGHE, EPX, IL5, RNASE3
20nedocromil sodium459.0IL5, IGHE, RNASE3, IL4
21omalizumab45 1110.0IGHE, IL4, IL5, IL13
22cyclosporin a45 29 6010.9IFNG, IGHE, RNASE3, CTLA4
23beclomethasone dipropionate458.9IGHE, RNASE3, IL5
24azelastine45 119.9IL5, IGHE, RNASE3, IL4
25polyinosinic-polycytidylic acid458.9IL5, IL10, IFNG, IL4
26prednisolone45 29 1110.9IGHE, RNASE3, IL13, IL5, EPX
27pgd2458.8IGHE, IL5, EPX, RNASE3, IL13
28il-12458.8IL5, IL4, IL10, IFNG, IL13
29pentoxifylline45 119.8IL10, IL4, IFNG, IL13
30con a458.8IL4, IL5, IL10, CTLA4, IFNG
31thalidomide45 50 60 1111.7IFNG, IL5, IL10, IL13, CTLA4
32methacholine45 119.6IL5, IL13, RNASE3, IGHE, IL4
33glatiramer acetate45 119.5IL5, IL4, IL10, IL13, CTLA4, IFNG
34il 10458.5IL5, IL4, IL10, IFNG, CTLA4, IL13
35salbutamol45 50 29 11 2412.4IL5, IL10, IL13, RNASE3, EPX, IGHE
36tacrolimus45 50 1110.4IFNG, CTLA4, IL4, IL10, IL13, IL5
37sb 20358045 609.3IL10, IL4, IL5, IFNG, IL13, STAT6
38infliximab45 50 1110.3IL10, IGHE, IL4, CTLA4, IFNG
39praziquantel45 119.3IGHE, IL13, IL10, IL5, IL4, RNASE3
40montelukast45 50 29 1111.3RNASE3, IL13, IL5, IL4, IGHE, IL10
41ivig458.2IFNG, IGHE, IL5, IL4, IL10
42thyroxine45 249.2IL13, IL10, IL5, IL4, IGHE
43ionomycin458.2IL5, IL10, STAT6, CTLA4, IFNG, IL4
44tarc458.0IGHE, IL4, IL13, IL5, IL10, IFNG
45budesonide45 50 1110.0IL4, IGHE, IFNG, EPX, RNASE3, IL13
46fluticasone propionate45 50 60 1110.9IL4, IFNG, STAT6, IGHE, RNASE3, IL13
47histamine45 29 249.2IL13, RNASE3, EPX, IGHE, STAT6, IFNG
48vegf457.0IGHE, RNASE3, IL13, IL5, IL10, IL4
49allergens456.9IFNG, CTLA4, STAT6, IGHE, EPX, RNASE3
50dexamethasone45 50 29 119.8IL5, IL4, IL10, IL13, RNASE3, EPX

GO Terms for genes affiliated with Urinary Schistosomiasis

Sources:
16Gene Ontology
See all sources

Cellular components related to Urinary Schistosomiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.6IL4, IL13, CTLA4, IFNG
2extracellular spaceGO:0056158.4IL4, IL5, IL10, IL13, IFNG

Biological processes related to Urinary Schistosomiasis according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1T-helper 1 cell lineage commitmentGO:00229610.0IL4, STAT6
2positive regulation of isotype switching to IgE isotypesGO:04829510.0IL4, STAT6
3regulation of proton transportGO:0101559.9IL13, IL4
4regulation of isotype switchingGO:0451919.9IL4, IL10
5type 2 immune responseGO:0420929.8IL4, IL10
6positive regulation of isotype switching to IgG isotypesGO:0483049.7IL4, IFNG
7negative regulation of nitric oxide biosynthetic processGO:0450199.7IL10, IL4
8positive regulation of chemokine biosynthetic processGO:0450809.7IL4, IFNG
9positive regulation of B cell proliferationGO:0308909.6IL13, IL5, IL4
10negative regulation of B cell proliferationGO:0308899.6CTLA4, IL10
11defense response to protozoanGO:0428329.5IL4, IFNG
12positive regulation of MHC class II biosynthetic processGO:0453489.4IL4, IL10, IFNG
13positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.4IL4, IL5, IL10
14defense response to bacteriumGO:0427429.2IL10, RNASE3, IFNG
15negative regulation of growth of symbiont in hostGO:0441309.2IL10, IFNG
16immune responseGO:0069558.5CTLA4, IGHE, IL13, IL5, IL4

Molecular functions related to Urinary Schistosomiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:0080839.2IL4, IL5, IL10
2cytokine activityGO:0051258.1IL4, IL5, IL10, IL13, IFNG

Products for genes affiliated with Urinary Schistosomiasis

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Sources for Urinary Schistosomiasis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet