MCID: URN003
MIFTS: 56

Urinary Schistosomiasis malady

Nephrological diseases, Blood diseases categories

Summaries for Urinary Schistosomiasis

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8Disease Ontology, 32MalaCards
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Disease Ontology:8 A schistosomiasis that involves parasitic infection of the urinary tract caused by a digenetic trematode schistosoma haematobium causing cystitis, ureteritis, fibrosis of the bladder and haematuria, which can progress to bladder cancer.

MalaCards: Urinary Schistosomiasis, also known as schistosoma hematobium infection, is related to schistosomiasis and malaria. An important gene associated with Urinary Schistosomiasis is EPX (eosinophil peroxidase), and among its related pathways are PEDF Induced Signaling and IL-4 Signaling and its Primary Biological Effects in Different Immune Cell Types. The compounds rolipram and pge2 have been mentioned in the context of this disorder. Affiliated tissues include testes, kidney and colon, and related mouse phenotypes are respiratory system and endocrine/exocrine gland.

Aliases & Classifications for Urinary Schistosomiasis

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8Disease Ontology, 10DISEASES, 60UMLS, 44Novoseek, 56SNOMED-CT, 34MeSH, 27ICD9CM, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological diseases, Blood diseases


Aliases & Descriptions:

urinary schistosomiasis 8 10 60
schistosoma hematobium infection 8 60
schistosomiasis due to schistosoma haematobium 8
schistosoma hematobium infectious disease 8
vesical schistosomiasis nos 8
cystitis with bilharziasis 8
schistosomiasis of bladder 8
schistosoma haematobium 8
bladder schistosomiasis 8
schistosomiasis urinary 44


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Disease Ontology8 DOID:1394
MeSH34 D012553
ICD9CM27 120.0

Related Diseases for Urinary Schistosomiasis

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17GeneCards, 18GeneDecks
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Diseases related to Urinary Schistosomiasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 164)
idRelated DiseaseScoreTop Affiliating Genes
1schistosomiasis31.9IFNG, IL4, RNASE3, IL13, IL10, IL5
2malaria30.4IFNG, IL10
3hepatitis30.2CTLA4
4onchocerciasis30.2EPX, RNASE3, IL5
5nephrotic syndrome30.0IL13
6hepatitis c30.0IFNG, IL10
7hepatitis b30.0IL10, IFNG, CTLA4
8proteinuria10.4
9plasmodium malariae malaria10.4
10plasmodium falciparum malaria10.4
11neuroschistosomiasis10.4
12intestinal schistosomiasis10.3
13ureteral obstruction10.2
14cerebritis10.2
15bladder neck obstruction10.2
16dacryoadenitis10.2
17vaginal discharge10.2
18vaginal disease10.2
19vaginitis10.2
20bacteriuria10.2
21bladder carcinoma10.2
22hypertension10.2
23trachoma10.0
24hydronephrosis10.0
25bladder carcinoma in situ10.0
26intestinal impaction10.0
27verrucous carcinoma10.0
28bladder squamous cell carcinoma10.0
29bladder transitional cell carcinoma10.0
30glomerulonephritis10.0
31in situ carcinoma10.0
32squamous cell carcinoma10.0
33transitional cell carcinoma10.0
34cystic fibrosis10.0RNASE3
35deficiency anemia10.0EPX
36bronchopulmonary dysplasia10.0RNASE3
37dilated cardiomyopathy10.0STAT6
38pulmonary fibrosis10.0IL13
39eosinophilic esophagitis10.0IL5
40mycosis fungoides10.0IL5
41hypothyroidism10.0CTLA4
42celiac disease10.0CTLA4
43hyperthyroidism10.0CTLA4
44eosinophilic fasciitis10.0IL5
45vasculitis10.0CTLA4
46osteoarthritis10.0CTLA4
47diabetes mellitus10.0CTLA4
48arthropathy10.0CTLA4
49chronic rhinitis10.0RNASE3
50thyroiditis10.0CTLA4

Graphical network of the top 20 diseases related to Urinary Schistosomiasis:



Diseases related to urinary schistosomiasis

Clinical Features for Urinary Schistosomiasis

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Drugs & Therapeutics for Urinary Schistosomiasis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Urinary Schistosomiasis

Drug clinical trials:

Search ClinicalTrials for Urinary Schistosomiasis

Search NIH Clinical Center for Urinary Schistosomiasis

Search CenterWatch for Urinary Schistosomiasis

Genetic Tests for Urinary Schistosomiasis

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Anatomical Context for Urinary Schistosomiasis

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32MalaCards
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MalaCards organs/tissues related to Urinary Schistosomiasis:

32
Testes, Kidney, Colon, Liver, Skin

Animal Models for Urinary Schistosomiasis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Urinary Schistosomiasis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538810.0CTLA4, STAT6
2MP:00053799.5IL4, IFNG
3MP:00053708.2IFNG, CTLA4, STAT6, IL10, IL5, IL4
4MP:00053818.1IFNG, CTLA4, IL13, IL10, IL5, IL4
5MP:00053898.1STAT6, IL13, IL10, IL5, IL4, IFNG
6MP:00107718.0IFNG, CTLA4, STAT6, IL13, IL10, IL4
7MP:00053976.9IL4, IFNG, CTLA4, STAT6, IGHE, EPX
8MP:00053876.8IFNG, CTLA4, STAT6, IGHE, EPX, IL13
9MP:00053766.6IFNG, CTLA4, STAT6, IGHE, IL13, IL10

Publications for Urinary Schistosomiasis

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50PubMed
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Articles related to Urinary Schistosomiasis:

(show top 50)    (show all 342)
idTitleAuthorsYear
1
Sonographic response in the liver and urinary bladder of children 14 months after treatment for schistosomiasis. (23796675)
2013
2
Urinary schistosomiasis transmission in Epe, an urban community of Southwest Nigeria. (23507989)
2011
3
Use of circulating cathodic antigen strips for the diagnosis of urinary schistosomiasis. (18951599)
2009
4
Micro-epidemiology of urinary schistosomiasis in Zanzibar: Local risk factors associated with distribution of infections among schoolchildren and relevance for control. (17996207)
2008
5
Elevated oxidative stress and DNA damage and repair levels in urinary bladder carcinomas associated with schistosomiasis. (18478569)
2008
6
Urinary schistosomiasis: an uncommon cause of gross hematuria in the industrialized countries. (17377821)
2007
7
Long-term outcomes of school-based treatment for control of urinary schistosomiasis: a review of experience in Coast Province, Kenya. (17308786)
2006
8
Impact of school health programme on urinary schistosomiasis control in schoolchildren in Kilosa, Tanzania. (16941948)
2005
9
Evaluation of CD4(+)/CD8(+) status and urinary tract infections associated with urinary schistosomiasis among some rural Nigerians. (16006219)
2005
10
Complement factors and circulating immune complexes in children with urinary schistosomiasis and asymptomatic malaria. (15971548)
2005
11
Preliminary studies on the prevalence and distribution of urinary schistosomiasis in Ondo State, Nigeria. (15819467)
2004
12
The prevalence, intensity and clinical signs of urinary schistosomiasis in Imo state, Nigeria. (15575992)
2004
13
Highly symptom-aware children were heavily infected with urinary schistosomiasis in southern Ghana. (14562596)
2003
14
Prevalence and intensity of urinary schistosomiasis in primary school children of the Kotto Barombi Health Area, Cameroon. (12002103)
2001
15
Health education and community participation in the control of urinary schistosomiasis in Ghana. (10750519)
1999
16
The public health significance of urinary schistosomiasis as a cause of morbidity in two districts in Mali. (9749635)
1998
17
New sites of Bulinus truncatus and indigenous cases of urinary schistosomiasis in Jordan. (9879562)
1998
18
Detection of urinary schistosomiasis in a low prevalence region. (9231197)
1997
19
The use of questionnaires for the identification of high risk areas for urinary schistosomiasis: the Ethiopian experience. (8840611)
1996
20
Urinary schistosomiasis in rural communities of some local government areas in Plateau State, Nigeria: a preliminary parasitological and malacological survey. (8960195)
1996
21
Urinary schistosomiasis in Nebraska. (7566250)
1995
22
Traditional herbal remedies used for the treatment of urinary schistosomiasis in Zimbabwe. (8072305)
1994
23
A synoptic inventory of needs for research on women and tropical parasitic diseases. I. Application to urinary and intestinal schistosomiasis. (7903837)
1993
24
Urinary schistosomiasis: testing with urine filtration and reagent sticks for haematuria provides a comparable prevalence estimate. (8096108)
1993
25
Diagnosis of active urinary schistosomiasis using homologous adult Schistosoma haematobium antigen. (8376848)
1993
26
Radiological changes and circulating immune complexes in patients with urinary schistosomiasis. (2508987)
1989
27
Verrucous carcinoma in situ of the bladder, not associated with urinary schistosomiasis. (2517753)
1989
28
Significance of eosinophiluria in urinary schistosomiasis. A study using Hansel's stain and electron microscopy. (2505608)
1989
29
The prevalence of urinary schistosomiasis among primary school children in Benue State, Nigeria. (2513784)
1989
30
Chronic urinary schistosomiasis: patterns of abnormalities in radionuclide Tc-99 m DTPA diuretic renogram. (3140850)
1988
31
Transmission of urinary schistosomiasis in Sukumaland, Tanzania. 1. Snail infection rates and incidence of infection in school children. (3192912)
1988
32
Urinary schistosomiasis in schoolchildren. (3124307)
1988
33
Screening methods for urinary schistosomiasis in an endemic area (the Kraboa/Coaltar district of Ghana). (3099659)
1986
34
Urinary schistosomiasis acquired in Mali, West Africa. II. Investigation of returnees exposed to risk environment. (3109752)
1986
35
Morbidity in urinary schistosomiasis: relation between sonographical lesions and pathological urine findings. (3936156)
1985
36
Circadian variation of ova excretion, proteinuria, hematuria, and leukocyturia in urinary schistosomiasis. (4040188)
1985
37
Day-to-day variation and circadian rhythm of egg excretion in urinary schistosomiasis in the Sudan. (6660966)
1983
38
Malumfashi Endemic Diseases Research Project, VI. Urinary schistosomiasis: abnormal urograms in infected males from the Malumfashi study area, northern Nigeria. (496461)
1979
39
IgE serum levels in urinary schistosomiasis. (543003)
1979
40
Malumfashi Endemic Diseases Research Project, III. Urinary schistosomiasis: a longitudinal study. (718301)
1978
41
Manifestations of urinary schistosomiasis in a British provincial city. (5162609)
1971
42
Mortality in urinary schistosomiasis. (4196042)
1970
43
Death attributed to kidney failure in communities with endemic urinary schistosomiasis. (4195155)
1970
44
Extracorporeal hemofiltration in urinary schistosomiasis. (5768770)
1969
45
LDH activity in urinary schistosomiasis and its complications. (5768446)
1969
46
Treatment of urinary schistosomiasis. Practice and theory. (4163311)
1967
47
Apossible relationship between the nephrotic syndrome and urinary schistosomiasis. (13947063)
1963
48
Treatment of active urinary schistosomiasis in children with sodium antimony dimercapto-succinate by the slow method. (13966736)
1963
49
Oral therapy of urinary schistosomiasis with Lucanthone Hcl. The effect of meclizine HCl on the incidence of its side effects. (13865624)
1961
50
Some observations on the problem of urinary schistosomiasis control in Adamawa Province, Northern Nigeria. (13659992)
1959

Genetic Variations for Urinary Schistosomiasis

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Expression for genes affiliated with Urinary Schistosomiasis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Urinary Schistosomiasis

Search GEO for disease gene expression data for Urinary Schistosomiasis.

Pathways for genes affiliated with Urinary Schistosomiasis

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51QIAGEN, 29KEGG, 52R&D Systems, 4Cell Signaling Technology, 12EMD Millipore, 37NCBI BioSystems Database, 53Reactome
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Pathways related to Urinary Schistosomiasis according to GeneCards/GeneDecks:

(show all 21)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.8IL13, IL5
29.8IL4, STAT6
3
Hide members
9.5IL10, IFNG
49.4IL4, IL5, IL13
5
Development Thrombopoetin signaling via JAK-STAT pathway
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9.2IL4, STAT6, IFNG
6
Hide members
9.2IL4, STAT6, IFNG
7
Development PDGF signaling via STATs and NF-kB
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9.2IFNG, STAT6, IL10
89.2IFNG, IL5, IL4
98.9IFNG, IL13, IL5, IL4
10
Hide members
8.8IL4, IL5, CTLA4, IFNG
11
Hide members
8.6STAT6, IL13, IL10, IL5, IL4
128.4IGHE, IL10, IL5, IL4
138.4IFNG, IL13, IL10, IL5, IL4
148.4IFNG, IL13, IL10, IL5, IL4
15
Hide members
8.4IFNG, CTLA4, IL10, IL5, IL4
16
Hide members
8.1IL5, IGHE, STAT6, CTLA4, IFNG
178.1IFNG, STAT6, IL13, IL10, IL5, IL4
18
Hide members
8.1IFNG, STAT6, IL13, IL10, IL5, IL4
19
Hide members
8.1IFNG, STAT6, IL13, IL10, IL5, IL4
20
Hide members
7.7IFNG, STAT6, IGHE, IL13, IL5, IL4
21
Hide members
7.5IL4, IFNG, CTLA4, EPX, RNASE3, IL13

Compounds for genes affiliated with Urinary Schistosomiasis

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44Novoseek, 59Tocris Bioscience, 28IUPHAR, 2BitterDB, 11DrugBank, 49PharmGKB, 24HMDB
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Compounds related to Urinary Schistosomiasis according to GeneCards/GeneDecks:

(show top 50)    (show all 134)
idCompoundScoreTop Affiliating Genes
1rolipram44 59 2812.7EPX
2pge24410.5EPX
3amphotericin b4410.4IL13
4indoleamine4410.4IL13
5hydrocortisone44 2 59 1113.0IGHE
6ovomucoid4410.0IGHE
7gm-csf44 2810.9IFNG, IL10
8rantes449.7IL4, RNASE3, IFNG
9ltc4449.5EPX, IL5, IL13, RNASE3
10salmeterol44 49 28 1112.3IL13, EPX, RNASE3, IL5, IL4
11betaseron449.3IL4, IL10, IFNG
12unicap449.2IL5, RNASE3, IGHE
13interferon gamma449.2IL4, IFNG, IL10
14alpha-galactosylceramide449.1IL10, IL4, IFNG, IL13
15tele-methylhistamine449.1EPX, RNASE3, IGHE
16sodium cromoglycate449.1IL5, RNASE3, EPX, IGHE
17cetirizine44 28 11 2412.1IGHE, EPX, RNASE3, IL5
18theophylline44 28 11 2412.1EPX, IL5, IL13, IL10, RNASE3
19ketotifen44 1110.1IGHE, EPX, IL5, RNASE3
20nedocromil sodium449.0IL5, IGHE, RNASE3, IL4
21omalizumab44 1110.0IGHE, IL4, IL5, IL13
22cyclosporin a44 28 5910.9IFNG, IGHE, RNASE3, CTLA4
23beclomethasone dipropionate448.9IGHE, RNASE3, IL5
24azelastine44 119.9IL5, IGHE, RNASE3, IL4
25polyinosinic-polycytidylic acid448.9IL5, IL10, IFNG, IL4
26prednisolone44 28 1110.9IGHE, RNASE3, IL13, IL5, EPX
27pgd2448.8IGHE, IL5, EPX, RNASE3, IL13
28il-12448.8IL5, IL4, IL10, IFNG, IL13
29pentoxifylline44 119.8IL10, IL4, IFNG, IL13
30con a448.8IL4, IL5, IL10, CTLA4, IFNG
31thalidomide44 49 59 1111.7IFNG, IL5, IL10, IL13, CTLA4
32methacholine44 119.6IL5, IL13, RNASE3, IGHE, IL4
33glatiramer acetate44 119.5IL5, IL4, IL10, IL13, CTLA4, IFNG
34il 10448.5IL5, IL4, IL10, IFNG, CTLA4, IL13
35salbutamol44 49 28 11 2412.4IL5, IL10, IL13, RNASE3, EPX, IGHE
36tacrolimus44 49 1110.4IFNG, CTLA4, IL4, IL10, IL13, IL5
37sb 20358044 599.3IL10, IL4, IL5, IFNG, IL13, STAT6
38infliximab44 49 1110.3IL10, IGHE, IL4, CTLA4, IFNG
39praziquantel44 119.3IGHE, IL13, IL10, IL5, IL4, RNASE3
40montelukast44 49 28 1111.3RNASE3, IL13, IL5, IL4, IGHE, IL10
41ivig448.2IFNG, IGHE, IL5, IL4, IL10
42thyroxine44 249.2IL13, IL10, IL5, IL4, IGHE
43ionomycin448.2IL5, IL10, STAT6, CTLA4, IFNG, IL4
44tarc448.0IGHE, IL4, IL13, IL5, IL10, IFNG
45budesonide44 49 1110.0IL4, IGHE, IFNG, EPX, RNASE3, IL13
46fluticasone propionate44 49 59 1110.9IL4, IFNG, STAT6, IGHE, RNASE3, IL13
47histamine44 28 249.2IL13, RNASE3, EPX, IGHE, STAT6, IFNG
48vegf447.0IGHE, RNASE3, IL13, IL5, IL10, IL4
49allergens446.9IFNG, CTLA4, STAT6, IGHE, EPX, RNASE3
50dexamethasone44 49 28 119.8IL5, IL4, IL10, IL13, RNASE3, EPX

GO Terms for genes affiliated with Urinary Schistosomiasis

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16Gene Ontology
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Cellular components related to Urinary Schistosomiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.6IL4, IL13, CTLA4, IFNG
2extracellular spaceGO:0056158.4IL4, IL5, IL10, IL13, IFNG

Biological processes related to Urinary Schistosomiasis according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1T-helper 1 cell lineage commitmentGO:00229610.0IL4, STAT6
2positive regulation of isotype switching to IgE isotypesGO:04829510.0IL4, STAT6
3regulation of proton transportGO:0101559.9IL13, IL4
4regulation of isotype switchingGO:0451919.9IL4, IL10
5type 2 immune responseGO:0420929.8IL4, IL10
6positive regulation of isotype switching to IgG isotypesGO:0483049.7IL4, IFNG
7negative regulation of nitric oxide biosynthetic processGO:0450199.7IL10, IL4
8positive regulation of chemokine biosynthetic processGO:0450809.7IL4, IFNG
9positive regulation of B cell proliferationGO:0308909.6IL13, IL5, IL4
10negative regulation of B cell proliferationGO:0308899.6CTLA4, IL10
11defense response to protozoanGO:0428329.5IL4, IFNG
12positive regulation of MHC class II biosynthetic processGO:0453489.4IL4, IL10, IFNG
13positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.4IL4, IL5, IL10
14defense response to bacteriumGO:0427429.2IL10, RNASE3, IFNG
15negative regulation of growth of symbiont in hostGO:0441309.2IL10, IFNG
16immune responseGO:0069558.5CTLA4, IGHE, IL13, IL5, IL4

Molecular functions related to Urinary Schistosomiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:0080839.2IL4, IL5, IL10
2cytokine activityGO:0051258.1IL4, IL5, IL10, IL13, IFNG

Products for genes affiliated with Urinary Schistosomiasis

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Sources for Urinary Schistosomiasis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet