MCID: URN003
MIFTS: 56

Urinary Schistosomiasis malady

Nephrological diseases, Blood diseases categories

Summaries for Urinary Schistosomiasis

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8Disease Ontology, 32MalaCards
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Disease Ontology:8 A schistosomiasis that involves parasitic infection of the urinary tract caused by a digenetic trematode schistosoma haematobium causing cystitis, ureteritis, fibrosis of the bladder and haematuria, which can progress to bladder cancer.

MalaCards: Urinary Schistosomiasis, also known as schistosoma hematobium infection, is related to schistosomiasis and malaria. An important gene associated with Urinary Schistosomiasis is EPX (eosinophil peroxidase), and among its related pathways are PEDF Induced Signaling and IL-4 Signaling and its Primary Biological Effects in Different Immune Cell Types. The compounds rolipram and pge2 have been mentioned in the context of this disorder. Affiliated tissues include testes, kidney and skin, and related mouse phenotypes are respiratory system and endocrine/exocrine gland.

Aliases & Classifications for Urinary Schistosomiasis

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8Disease Ontology, 10DISEASES, 60UMLS, 44Novoseek, 56SNOMED-CT, 34MeSH, 27ICD9CM, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological diseases, Blood diseases


Aliases & Descriptions:

urinary schistosomiasis 8 10 60
schistosoma hematobium infection 8 60
schistosomiasis due to schistosoma haematobium 8
schistosoma hematobium infectious disease 8
vesical schistosomiasis nos 8
cystitis with bilharziasis 8
schistosomiasis of bladder 8
schistosoma haematobium 8
bladder schistosomiasis 8
schistosomiasis urinary 44


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Disease Ontology8 DOID:1394
MeSH34 D012553
ICD9CM27 120.0

Related Diseases for Urinary Schistosomiasis

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17GeneCards, 18GeneDecks
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Diseases related to Urinary Schistosomiasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 164)
idRelated DiseaseScoreTop Affiliating Genes
1schistosomiasis31.9IFNG, IL4, RNASE3, IL13, IL10, IL5
2malaria30.4IFNG, IL10
3hepatitis30.2CTLA4
4onchocerciasis30.2EPX, RNASE3, IL5
5nephrotic syndrome30.0IL13
6hepatitis c30.0IFNG, IL10
7hepatitis b30.0IL10, IFNG, CTLA4
8proteinuria10.4
9plasmodium malariae malaria10.4
10plasmodium falciparum malaria10.4
11neuroschistosomiasis10.4
12intestinal schistosomiasis10.3
13ureteral obstruction10.2
14cerebritis10.2
15bladder neck obstruction10.2
16dacryoadenitis10.2
17vaginal discharge10.2
18vaginal disease10.2
19vaginitis10.2
20bacteriuria10.2
21bladder carcinoma10.2
22hypertension10.2
23trachoma10.0
24hydronephrosis10.0
25bladder carcinoma in situ10.0
26intestinal impaction10.0
27verrucous carcinoma10.0
28bladder squamous cell carcinoma10.0
29bladder transitional cell carcinoma10.0
30glomerulonephritis10.0
31in situ carcinoma10.0
32squamous cell carcinoma10.0
33transitional cell carcinoma10.0
34cystic fibrosis10.0RNASE3
35deficiency anemia10.0EPX
36bronchopulmonary dysplasia10.0RNASE3
37dilated cardiomyopathy10.0STAT6
38pulmonary fibrosis10.0IL13
39eosinophilic esophagitis10.0IL5
40mycosis fungoides10.0IL5
41hypothyroidism10.0CTLA4
42celiac disease10.0CTLA4
43hyperthyroidism10.0CTLA4
44eosinophilic fasciitis10.0IL5
45vasculitis10.0CTLA4
46osteoarthritis10.0CTLA4
47diabetes mellitus10.0CTLA4
48arthropathy10.0CTLA4
49chronic rhinitis10.0RNASE3
50thyroiditis10.0CTLA4

Graphical network of the top 20 diseases related to Urinary Schistosomiasis:



Diseases related to urinary schistosomiasis

Clinical Features for Urinary Schistosomiasis

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Drugs & Therapeutics for Urinary Schistosomiasis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Urinary Schistosomiasis

Drug clinical trials:

Search ClinicalTrials for Urinary Schistosomiasis

Search NIH Clinical Center for Urinary Schistosomiasis

Search CenterWatch for Urinary Schistosomiasis

Genetic Tests for Urinary Schistosomiasis

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Anatomical Context for Urinary Schistosomiasis

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32MalaCards
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MalaCards organs/tissues related to Urinary Schistosomiasis:

32
Testes, Kidney, Skin, Liver, Colon

Animal Models for Urinary Schistosomiasis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Urinary Schistosomiasis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538810.0CTLA4, STAT6
2MP:00053799.5IL4, IFNG
3MP:00053708.2IFNG, CTLA4, STAT6, IL10, IL4, IL5
4MP:00053818.1IL13, IL5, IL4, IFNG, CTLA4, IL10
5MP:00053898.1IFNG, STAT6, IL13, IL10, IL4, IL5
6MP:00107718.0CTLA4, IL13, IL10, IL4, STAT6, IFNG
7MP:00053976.9IGHE, IL10, IL13, EPX, IL4, STAT6
8MP:00053876.8STAT6, IFNG, CTLA4, IL4, IGHE, EPX
9MP:00053766.6IL4, IFNG, CTLA4, STAT6, IGHE, IL13

Publications for Urinary Schistosomiasis

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50PubMed
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Articles related to Urinary Schistosomiasis:

(show top 50)    (show all 342)
idTitleAuthorsYear
1
A pilot study on cytotoxic T lymphocyte-4 gene polymorphisms in urinary schistosomiasis. (22288822)
2012
2
Proportion of Urinary Schistosomiasis among HIV-Infected Subjects in Benin City, Nigeria. (22043410)
2011
3
Preparing for national school-based deworming in Kenya: the validation and large-scale distribution of school questionnaires with urinary schistosomiasis. (21767334)
2011
4
The performance of haematuria reagent strips for the rapid mapping of urinary schistosomiasis: field experience from Southern Sudan. (19818057)
2009
5
Diagnostic accuracy of different urine dipsticks to detect urinary schistosomiasis: a comparative study in five endemic communities in Osun and Ogun States, Nigeria. (19068147)
2009
6
Treatment of urinary schistosomiasis: methodological issues and research needs identified through a Cochrane systematic review. (19493363)
2009
7
A wake up call for urinary schistosomiasis: reconciling research effort with public health importance. (19627633)
2009
8
A simple approach improving the performance of urine reagent strips for rapid diagnosis of urinary schistosomiasis in Nigerian schoolchildren. (19547872)
2009
9
Human urinary schistosomiasis transmission foci and period in an endemic town of Ijebu North, Southwest Nigeria. (16493394)
2004
10
Some social determinants of urinary schistosomiasis in Northern Cameroon: implications for schistosomiasis control. (17298128)
2004
11
Urinary schistosomiasis in a Japanese man. (15242371)
2004
12
Urinary schistosomiasis. (12205023)
2002
13
Implication of Bulinus truncatus in the transmission of urinary schistosomiasis in Senegal, West Africa. (12080978)
2002
14
Urinary schistosomiasis in southern Ghana: a logistic regression approach to data from a community-based integrated control program. (11716102)
2001
15
Recent urban growth and urinary schistosomiasis in Niamey, Niger. (10929143)
2000
16
Morbidity assessment in urinary schistosomiasis infection through ultrasonography and measurement of eosinophil cationic protein (ECP) in urine. (10747267)
2000
17
Control of urinary schistosomiasis: an investigation into the effective use of questionnaires to identify high-risk communities and individuals in Niger State, Nigeria. (10672206)
2000
18
Concurrent infections and neutrophil phagocytic function in Nigerians with urinary schistosomiasis. (12953997)
1999
19
The diagnostic potential of three indirect tests for urinary schistosomiasis in Nigeria. (9492912)
1997
20
Serum immunoglobins in Nigerians with urinary schistosomiasis. (9337015)
1997
21
Urinary schistosomiasis: options for control within endemic rural communities: a case study in south-west Nigeria. (8757703)
1996
22
Decline of urinary schistosomiasis in Kurmuk town, western Ethio-Sudanese border, Ethiopia. (8674500)
1996
23
Preliminary study of urinary schistosomiasis in a village in the delta of the Senegal river basin, Senegal. (7570817)
1994
24
Estimation of prevalences of urinary schistosomiasis using haematuria. (7954730)
1994
25
Egg viability in urinary schistosomiasis. II. Simplifying modifications and standardization of new methods. (7681485)
1993
26
Indirect assessment of eosinophiluria in urinary schistosomiasis using eosinophil cationic protein (ECP) and eosinophil protein X (EPX). (8103623)
1993
27
Urological complications following live donor kidney transplantation: effect of urinary schistosomiasis. (1422682)
1992
28
Urinary schistosomiasis in the Sichili Health Zone, Western Province, Zambia. (1801143)
1991
29
Urinary schistosomiasis: influence of the circadian variation of hematuria and proteinuria on reagent stick testing. (1674405)
1991
30
Urinary schistosomiasis and the coming of age in Nigeria. (15463425)
1991
31
Field diagnosis of urinary schistosomiasis by multiple use of nuclepore urine filters. (2498496)
1989
32
Efficacy of metrifonate in a highly endemic area of urinary schistosomiasis in Kenya. (3124647)
1988
33
Screening and treatment of urinary schistosomiasis in Dar es Salaam. (3102735)
1987
34
Transmission of urinary schistosomiasis in man-made habitats in The Gambia. (3111025)
1986
35
Urban transmission of urinary schistosomiasis in Dar es Salaam, Tanzania. (2859753)
1985
36
Urinary schistosomiasis in a sheep: a case report. (6476936)
1984
37
Intermittent chemotherapy with trichlorfon (metrifonate) reverses proteinuria, hematuria, and leukocyturia in urinary schistosomiasis: results of a three-year field study. (6725993)
1984
38
The oral treatment of urinary schistosomiasis in Egyptian patients with 'Oltipraz'. (6474558)
1984
39
Treatment of urinary schistosomiasis. (5058172)
1972
40
Urinary schistosomiasis treated with sodium antimony tartrate--a quantitative evaluation. (4877078)
1968
41
Steroid therapy in chronic urinary schistosomiasis (bilharziasis). (6050892)
1967
42
Treatment of urinary schistosomiasis with niridazole (Ambilhar) in 576 African schoolchildren. (4163775)
1967
43
Astiban therapy of urinary schistosomiasis: a quantitative evaluation. (5962469)
1966
44
Relation between urinary schistosomiasis and chronic enteric urinary carrier state among Egyptians. (4956231)
1966
45
TREATMENT OF URINARY SCHISTOSOMIASIS IN GHANAIANS WITH TWSB (ASTIBAN). (14222434)
1964
46
THE USE OF ANTIGENS PREPARED FROM ADULT FASCIOLA GIGANTICA, SCHISTOSOMA MANSONI AND SCHISTOSOMA BOVIS IN THE DIAGNOSIS OF URINARY SCHISTOSOMIASIS BY THE INTRA-DERMAL TEST (IDT). (14081299)
1963
47
Urinary Schistosomiasis in Ibadan school-children. (14036619)
1962
48
Ambulant treatment of urinary schistosomiasis with Astiban (TWSb/6). (13865538)
1962
49
The test of cure in urinary schistosomiasis. (13422576)
1957
50
Bacteriological flora in urinary schistosomiasis; a report on 150 cases. (20242818)
1946

Genetic Variations for Urinary Schistosomiasis

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Expression for genes affiliated with Urinary Schistosomiasis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Urinary Schistosomiasis

Search GEO for disease gene expression data for Urinary Schistosomiasis.

Pathways for genes affiliated with Urinary Schistosomiasis

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51QIAGEN, 29KEGG, 52R&D Systems, 4Cell Signaling Technology, 12EMD Millipore, 37NCBI BioSystems Database, 53Reactome
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Pathways related to Urinary Schistosomiasis according to GeneCards/GeneDecks:

(show all 21)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.8IL5, IL13
29.8IL4, STAT6
3
Hide members
9.5IL10, IFNG
49.4IL4, IL5, IL13
5
Development Thrombopoetin signaling via JAK-STAT pathway
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9.2IFNG, STAT6, IL4
6
Hide members
9.2IFNG, STAT6, IL4
7
Development PDGF signaling via STATs and NF-kB
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9.2IL10, STAT6, IFNG
89.2IL4, IL5, IFNG
98.9IL5, IFNG, IL13, IL4
10
Hide members
8.8IFNG, IL4, IL5, CTLA4
11
Hide members
8.6IL4, IL5, IL10, IL13, STAT6
128.4IL4, IL5, IL10, IGHE
138.4IFNG, IL13, IL10, IL5, IL4
148.4IL13, IL5, IL4, IFNG, IL10
15
Hide members
8.4IFNG, CTLA4, IL10, IL5, IL4
16
Hide members
8.1IGHE, IFNG, CTLA4, STAT6, IL5
178.1IFNG, IL13, IL10, IL5, IL4, STAT6
18
Hide members
8.1IL5, STAT6, IL13, IL10, IFNG, IL4
19
Hide members
8.1IL10, IL13, IFNG, STAT6, IL4, IL5
20
Hide members
7.7STAT6, IL4, IFNG, IL5, IL13, IGHE
21
Hide members
7.5IL5, IL4, IL10, IL13, RNASE3, EPX

Compounds for genes affiliated with Urinary Schistosomiasis

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44Novoseek, 59Tocris Bioscience, 28IUPHAR, 2BitterDB, 11DrugBank, 49PharmGKB, 24HMDB
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Compounds related to Urinary Schistosomiasis according to GeneCards/GeneDecks:

(show top 50)    (show all 134)
idCompoundScoreTop Affiliating Genes
1rolipram44 59 2812.7EPX
2pge24410.5EPX
3amphotericin b4410.4IL13
4indoleamine4410.4IL13
5hydrocortisone44 2 59 1113.0IGHE
6ovomucoid4410.0IGHE
7gm-csf44 2810.9IFNG, IL10
8rantes449.7IL4, RNASE3, IFNG
9ltc4449.5EPX, IL5, IL13, RNASE3
10salmeterol44 49 28 1112.3IL13, EPX, RNASE3, IL5, IL4
11betaseron449.3IL4, IL10, IFNG
12unicap449.2IL5, RNASE3, IGHE
13interferon gamma449.2IL4, IFNG, IL10
14alpha-galactosylceramide449.1IL10, IL4, IFNG, IL13
15tele-methylhistamine449.1EPX, RNASE3, IGHE
16sodium cromoglycate449.1IL5, RNASE3, EPX, IGHE
17cetirizine44 28 11 2412.1IGHE, EPX, RNASE3, IL5
18theophylline44 28 11 2412.1EPX, IL5, IL13, IL10, RNASE3
19ketotifen44 1110.1IGHE, EPX, IL5, RNASE3
20nedocromil sodium449.0IL5, IGHE, RNASE3, IL4
21omalizumab44 1110.0IGHE, IL4, IL5, IL13
22cyclosporin a44 28 5910.9IFNG, IGHE, RNASE3, CTLA4
23beclomethasone dipropionate448.9IGHE, RNASE3, IL5
24azelastine44 119.9IL5, IGHE, RNASE3, IL4
25polyinosinic-polycytidylic acid448.9IL5, IL10, IFNG, IL4
26prednisolone44 28 1110.9IGHE, RNASE3, IL13, IL5, EPX
27pgd2448.8IGHE, IL5, EPX, RNASE3, IL13
28il-12448.8IL5, IL4, IL10, IFNG, IL13
29pentoxifylline44 119.8IL10, IL4, IFNG, IL13
30con a448.8IL4, IL5, IL10, CTLA4, IFNG
31thalidomide44 49 59 1111.7IFNG, IL5, IL10, IL13, CTLA4
32methacholine44 119.6IL5, IL13, RNASE3, IGHE, IL4
33glatiramer acetate44 119.5IL5, IL4, IL10, IL13, CTLA4, IFNG
34il 10448.5IL5, IL4, IL10, IFNG, CTLA4, IL13
35salbutamol44 49 28 11 2412.4IL5, IL10, IL13, RNASE3, EPX, IGHE
36tacrolimus44 49 1110.4IFNG, CTLA4, IL4, IL10, IL13, IL5
37sb 20358044 599.3IL10, IL4, IL5, IFNG, IL13, STAT6
38infliximab44 49 1110.3IL10, IGHE, IL4, CTLA4, IFNG
39praziquantel44 119.3IGHE, IL13, IL10, IL5, IL4, RNASE3
40montelukast44 49 28 1111.3RNASE3, IL13, IL5, IL4, IGHE, IL10
41ivig448.2IFNG, IGHE, IL5, IL4, IL10
42thyroxine44 249.2IL13, IL10, IL5, IL4, IGHE
43ionomycin448.2IL5, IL10, STAT6, CTLA4, IFNG, IL4
44tarc448.0IGHE, IL4, IL13, IL5, IL10, IFNG
45budesonide44 49 1110.0IL4, IGHE, IFNG, EPX, RNASE3, IL13
46fluticasone propionate44 49 59 1110.9IL4, IFNG, STAT6, IGHE, RNASE3, IL13
47histamine44 28 249.2IL13, RNASE3, EPX, IGHE, STAT6, IFNG
48vegf447.0IGHE, RNASE3, IL13, IL5, IL10, IL4
49allergens446.9IFNG, CTLA4, STAT6, IGHE, EPX, RNASE3
50dexamethasone44 49 28 119.8IL5, IL4, IL10, IL13, RNASE3, EPX

GO Terms for genes affiliated with Urinary Schistosomiasis

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16Gene Ontology
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Cellular components related to Urinary Schistosomiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.6IL4, IL13, CTLA4, IFNG
2extracellular spaceGO:0056158.4IL4, IL5, IL10, IL13, IFNG

Biological processes related to Urinary Schistosomiasis according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1T-helper 1 cell lineage commitmentGO:00229610.0IL4, STAT6
2positive regulation of isotype switching to IgE isotypesGO:04829510.0IL4, STAT6
3regulation of proton transportGO:0101559.9IL13, IL4
4regulation of isotype switchingGO:0451919.9IL4, IL10
5type 2 immune responseGO:0420929.8IL4, IL10
6positive regulation of isotype switching to IgG isotypesGO:0483049.7IL4, IFNG
7negative regulation of nitric oxide biosynthetic processGO:0450199.7IL10, IL4
8positive regulation of chemokine biosynthetic processGO:0450809.7IL4, IFNG
9positive regulation of B cell proliferationGO:0308909.6IL13, IL5, IL4
10negative regulation of B cell proliferationGO:0308899.6CTLA4, IL10
11defense response to protozoanGO:0428329.5IL4, IFNG
12positive regulation of MHC class II biosynthetic processGO:0453489.4IL4, IL10, IFNG
13positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.4IL4, IL5, IL10
14defense response to bacteriumGO:0427429.2IL10, RNASE3, IFNG
15negative regulation of growth of symbiont in hostGO:0441309.2IL10, IFNG
16immune responseGO:0069558.5CTLA4, IGHE, IL13, IL5, IL4

Molecular functions related to Urinary Schistosomiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:0080839.2IL4, IL5, IL10
2cytokine activityGO:0051258.1IL4, IL5, IL10, IL13, IFNG

Products for genes affiliated with Urinary Schistosomiasis

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  • Antibodies
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Sources for Urinary Schistosomiasis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet