MCID: URN009
MIFTS: 50

Urinary System Disease malady

Categories: Nephrological diseases

Aliases & Classifications for Urinary System Disease

Aliases & Descriptions for Urinary System Disease:

Name: Urinary System Disease 12 29 14
Congenital Malformation of the Urinary System 69
Non-Neoplastic Urinary System Disorder 69
Non-Neoplastic Urinary Tract Disease 12
Urinary Tract Diseases 52
Urinary Tract Disease 12
Urinary Tract Anomaly 52
Urologic Diseases 69

Classifications:



External Ids:

Disease Ontology 12 DOID:18
NCIt 47 C27599
UMLS 69 C1335051

Summaries for Urinary System Disease

Disease Ontology : 12 A disease of anatomical entity that is located in kidney, ureter, bladder and urethra.

MalaCards based summary : Urinary System Disease, also known as congenital malformation of the urinary system, is related to pyelonephritis and exstrophy of bladder bladder exstrophy and epispadias complex, included, and has symptoms including dysuria, polyuria and pain in urethra. An important gene associated with Urinary System Disease is B2M (Beta-2-Microglobulin), and among its related pathways/superpathways is Osteoblast Signaling. The drugs Levofloxacin and Ofloxacin have been mentioned in the context of this disorder. Affiliated tissues include kidney, smooth muscle and kidney, and related phenotypes are homeostasis/metabolism and cardiovascular system

Wikipedia : 71 The urinary system, also known as the renal system, consists of the kidneys, ureters, bladder, and the... more...

Related Diseases for Urinary System Disease

Diseases related to Urinary System Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 111)
id Related Disease Score Top Affiliating Genes
1 pyelonephritis 30.0 ACE CRP REN
2 exstrophy of bladder bladder exstrophy and epispadias complex, included 10.8
3 lower urinary tract calculus 10.7
4 bladder disease 10.7
5 urethral syndrome 10.7
6 bacteriuria 10.7
7 ureteral disease 10.7
8 kidney disease 10.7
9 atopic dermatitis 6 10.4 ALB CD79A
10 hypotrichosis simplex 10.4 ACE REN
11 gliosarcoma 10.4 ALB B2M NAGLU
12 prostate neuroendocrine neoplasm 10.4 ACE ALB REN
13 spondyloarthropathy 2 10.4 ACE ALB NAGLU
14 gilles de la tourette syndrome 10.4 ALB B2M
15 angiokeratoma 10.4 ALB B2M CD79A
16 striatonigral degeneration 10.4 ALB CD79A PTH
17 breast metaplastic carcinoma 10.4 B2M EPO PTH
18 venezuelan equine encephalitis 10.4 ALB B2M CD79A
19 dientamoebiasis 10.4 ACE EPO REN
20 secernentea infections 10.4 CD79A PTH
21 transsexualism 10.4 ALB AVP REN
22 colloid adenoma 10.4 ALB CD79A
23 aphthous stomatitis 10.4 ALB NPHS1 NPHS2
24 early yaws 10.4 ALB B2M CD79A
25 syringomelia hyperkeratosis 10.4 ACE ALB AVP
26 henoch-schoenlein purpura 10.4 ALB B2M NAGLU
27 hyperinsulinemic hypoglycemia, familial, 3 10.4 ACE REN
28 plummer's disease 10.4 ALB B2M CRP
29 pythiosis 10.4 ACE EPO REN
30 fallopian tube serous adenocarcinoma 10.4 ALB CRP NAGLU
31 dermatomycosis 10.4 ALB CD79A CRP
32 acute lymphoblastic leukemia, childhood 10.4 ALB B2M CST3 REN
33 schneiderian carcinoma 10.4 ALB CD79A
34 allergic bronchopulmonary aspergillosis 10.4 ALB CRP KLK3
35 central nervous system origin vertigo 10.4 B2M CD79A MGEA5
36 myopia 10.4 ACE ALB CST3 REN
37 spastic entropion 10.4 ALB CD79A CRP
38 agammaglobulinemia 6 10.4 ACE ALB NAGLU NPHS1
39 opiate dependence 10.4 ACE AVP CST3
40 hypertrichosis of eyelid 10.4 ACE NPHS1 NPHS2
41 toxic myocarditis 10.4 ACE CRP CST3
42 petrositis 10.4 ACE ALB EPO REN
43 ischemic optic neuropathy 10.4 ACE ALB CRP
44 anterior foramen magnum meningioma 10.4 ALB B2M CD79A EPO
45 prediabetes syndrome 10.4 AVP FGF23 PTH
46 paranasal sinus sarcoma 10.4 ALB CD79A REN
47 gait apraxia 10.4 ACE ALB CRP
48 choroiditis 10.4 ACE ALB CRP NAGLU
49 focal dystonia 10.4 ACE CRP CST3
50 indian tick typhus 10.4 FGF23 PTH REN

Graphical network of the top 20 diseases related to Urinary System Disease:



Diseases related to Urinary System Disease

Symptoms & Phenotypes for Urinary System Disease

UMLS symptoms related to Urinary System Disease:


dysuria, polyuria, pain in urethra, renal colic, urethral burning on micturition, loin pain, ureteral pain, flank tenderness, difficulty passing urine, urinary tenesmus, burning urination, uti symptoms, bladder discomfort, renal pain, other and unspecified genitourinary symptoms, urologic problem

MGI Mouse Phenotypes related to Urinary System Disease:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.13 ACE ALB AVP B2M CD79A CRP
2 cardiovascular system MP:0005385 10.11 ACE B2M CRP CST3 EPO FGF23
3 hematopoietic system MP:0005397 10.02 ACE B2M CD79A EPO FGF23 LCN2
4 immune system MP:0005387 9.93 CRP EPO FGF23 LCN2 NAGLU PTH
5 mortality/aging MP:0010768 9.83 REN SIX1 ACE ALB AVP B2M
6 renal/urinary system MP:0005367 9.4 UMOD ACE ALB AVP CD79A FGF23

Drugs & Therapeutics for Urinary System Disease

Drugs for Urinary System Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 1187)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Levofloxacin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 100986-85-4 149096
2
Ofloxacin Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 82419-36-1 4583
3
Nitrofurantoin Approved, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1 67-20-9 5353830
4
Trimethoprim Approved, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 738-70-5 5578
5
Cefotaxime Approved Phase 4 63527-52-6 456256 5742673
6
Cefoxitin Approved Phase 4 35607-66-0 441199
7
Sulbactam Approved Phase 4,Phase 3,Phase 2 68373-14-8
8
Piperacillin Approved Phase 4,Phase 3,Phase 2 66258-76-2 43672
9
Tacrolimus Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 104987-11-3 445643 439492
10
Pitavastatin Approved Phase 4 147511-69-1, 147526-32-7 6366718 5282452
11
Everolimus Approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 159351-69-6 6442177
12
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 22916-47-8 4189
13
Sirolimus Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 53123-88-9 5284616 6436030 46835353
14
Acetylcysteine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 616-91-1 12035
15
Cyclosporine Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 79217-60-0, 59865-13-3 5284373 6435893
16
Daclizumab Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 152923-56-3
17
Mycophenolate mofetil Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 128794-94-5 5281078
18
Mycophenolic acid Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 24280-93-1 446541
19
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 53-03-2 5865
20
alemtuzumab Approved, Investigational Phase 4,Phase 1,Phase 2 216503-57-0
21
Candesartan Approved Phase 4,Phase 3,Phase 2,Phase 1 139481-59-7 2541
22
Enalapril Approved, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 75847-73-3 5362032 40466924
23
Enalaprilat Approved Phase 4,Phase 3,Phase 1,Phase 2 76420-72-9 6917719
24
Iron Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 7439-89-6 23925
25
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603
26
Perindopril Approved Phase 4 107133-36-8, 82834-16-0 107807
27
Valsartan Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 137862-53-4 60846
28
Digoxin Approved Phase 4 20830-75-5 30322 2724385
29
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741 24759
30
Furosemide Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 54-31-9 3440
31
Hydrochlorothiazide Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 58-93-5 3639
32
Heparin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 9005-49-6 772 46507594
33
Basiliximab Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 152923-56-3, 179045-86-4
34
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 83-43-2 6741
35
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-24-8 5755
36
Spironolactone Approved Phase 4,Phase 3,Phase 2,Phase 1 1952-01-7, 52-01-7 5833
37
Benzocaine Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 1994-09-7, 94-09-7 2337
38
Simvastatin Approved Phase 4,Phase 3,Phase 1 79902-63-9 54454
39
Nitric Oxide Approved Phase 4,Phase 2,Phase 3,Phase 1 10102-43-9 145068
40
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 2,Phase 3 76631-46-4, 113775-47-6 68602 5311068 56032
41
Nifedipine Approved Phase 4,Phase 3,Phase 2,Phase 1 21829-25-4 4485
42
Progesterone Approved, Vet_approved Phase 4 57-83-0 5994
43
Propantheline Approved Phase 4,Phase 1 298-50-0 4934
44
Tamsulosin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 106133-20-4 129211
45
Cilnidipine Approved Phase 4,Phase 2 132203-70-4 5282138
46
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 9552079 2713
47
Povidone-iodine Approved Phase 4,Phase 2 25655-41-8
48
Zaleplon Approved, Illicit, Investigational Phase 4 151319-34-5 5719
49 Moxonidine Approved Phase 4 75438-57-2 4810
50
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 1 50-78-2 2244

Interventional clinical trials:

(show top 50) (show all 5000)
id Name Status NCT ID Phase
1 Folic Acid for Prevention of Contrast Induced Nephropathy Unknown status NCT02444013 Phase 4
2 Low Dose Estriol With Lactobacilli Treatment for Preventing Recurrent Urinary Tract Infection in Postmenopausal Women Unknown status NCT00900653 Phase 4
3 The Efficacy of Solifenacin Succinate as Adjuvant Therapy for Urinary Tract Infection in Females Unknown status NCT02094703 Phase 4
4 Evaluation of the Effectiveness of Antibiotic Prophylaxis in Children With a Previous Urinary Tract Infection Unknown status NCT00156546 Phase 4
5 Effects of Antibiotic Prophylaxis on Recurrent UTI in Children Unknown status NCT02357758 Phase 4
6 Gentamicin Bladder Instillation Trial Unknown status NCT01884467 Phase 4
7 Study on Cefotaxime and Sulbactam Sodium for Injection (2:1) for Treatment of Respiratory and Urinary Tract Infection Unknown status NCT01426191 Phase 4
8 Piperacillin Sodium and Sulbactam Sodium for Injection (2:1) for Treatment of Respiratory and Urinary Tract Infection Unknown status NCT01897831 Phase 4
9 Practical Use of Advagraf de Novo After Kidney Transplantation According to Recipient Genetic Polymorphism Unknown status NCT02311010 Phase 4
10 Preventive Effect of Pitavastatin on Contrast-Induced Nephropathy in Patients With Renal Dysfunction Unknown status NCT01871792 Phase 4
11 The Effects of AST-120 on Endothelial Dysfunction in Patients With Chronic Kidney Disease Unknown status NCT01157260 Phase 4
12 Impact of Conversion From Tacrolimus to Sirolimus in African American Renal Transplant Recipients Unknown status NCT00999258 Phase 4
13 Prevention of Contrast-Induced Nephropathy in Diabetic Patients With Undergoing Coronary Angiography Unknown status NCT00950079 Phase 4
14 Effect of Intravenous Acetadote on Incidence of Contrast Induced Nephropathy Unknown status NCT00939913 Phase 4
15 Safe Renal Function In Long Term Heart Transplanted Patients Unknown status NCT00505102 Phase 4
16 Reduction or Discontinuation of CNI's With Conversion to Everolimus-Based Immunosuppresion Unknown status NCT00443508 Phase 4
17 Renal Function Optimization With Mycophenolate Mofetil (MMF) Immunosuppressor Regimes (ALHAMBRA) Unknown status NCT00290069 Phase 4
18 A Study Comparing Outcomes of Kidney Transplants in Patients on Steroids Versus Those Who Discontinue Steroids Unknown status NCT00273559 Phase 4
19 Comparison of Alemtuzumab/Tacrolimus Versus Interleukin-2 Receptor (IL-2R) Monoclonal Antibody (MoAb)/Tacrolimus/Mycophenolate in Kidney Transplantation Unknown status NCT00246129 Phase 4
20 Pulse Wave Velocity, Pulse Wave Morphology and Blocking of the Reninangiotensin System in Patients With Chronic Kidney Disease Unknown status NCT00235287 Phase 4
21 Intravenous Iron in Patients With Anemia of Chronic Kidney Disease Unknown status NCT00204256 Phase 4
22 Piperacillin Sodium and Sulbactam Sodium for Injection(2:1) for Treatment of Respiratory and Urinary System Infection Unknown status NCT01760109 Phase 4
23 Opioids in Chronic Kidney Disease Patients Undergoing Hemodialysis Unknown status NCT02452437 Phase 4
24 Effect of Valsartan vs Perindopril on HOMA-IR Index in Patients With Chronic Kidney Disease Unknown status NCT02299310 Phase 4
25 Effect of Vitamin D Supplement on Osteoprotegin Expression and Disease Progression in Patients With Chronic Kidney Disease Stage 1 and 2 Unknown status NCT01561222 Phase 4
26 Enhancing Dialysis Adequacy: Effects of Intradialytic Exercise Unknown status NCT01481688 Phase 4
27 The Prevention of Contrast Induced Nephropathy by Sarpogrelate in Patients With Chronic Kidney Disease Unknown status NCT01165567 Phase 4
28 Effects of an Exercise Program in Patients With Hypertensive Chronic Kidney Disease Unknown status NCT01155128 Phase 4
29 Anti-Oxidant Effect on Peritoneal Membrane in Peritoneal Dialysis (PD) Patients Unknown status NCT01111422 Phase 4
30 Pilot Study Evaluating Doxercalciferol Replacement Therapy in Kidney Transplant Recipients Unknown status NCT00889629 Phase 4
31 Marinobufagenin as a Target for DIGIBIND in Hypertensive Patients With End-stage Renal Disease Unknown status NCT00852787 Phase 4
32 More Frequent Dialysis (>3 Treatments Per Week) Unknown status NCT00575497 Phase 4
33 Keto-/Amino Acid Supplemented Low Protein Diet in Patients With Chronic Kidney Disease Unknown status NCT00364884 Phase 4
34 The Canadian Prevention of Renal and Cardiovascular Endpoints Trial Unknown status NCT00231803 Phase 4
35 A Prospective Study Comparing the Success Rate of Injection of (DefluxR) Versus (VantrisR) for VUR in Children Unknown status NCT02271035 Phase 4
36 Efficacy of Combined Intravesical Therapy With Hyaluronic Acid and Chondroitin Sulphate in the Treatment of Recurrent Cystitis Refractory to Escherichia Coli Extract Unknown status NCT02366676 Phase 4
37 Clinical Trial to Compare Effectiveness of Diuretics in Hemodialysis Patients With Residual Renal Function Unknown status NCT01977430 Phase 4
38 Citrate Versus Heparin for the Lock of Non-tunneled Hemodialysis Catheters in Patients Hospitalised in ICU Unknown status NCT01962116 Phase 4
39 Effect of 3g Versus 2 g MMF in Combination With Tacrolimus on Progression of Renal Allograft Interstitial Fibrosis Unknown status NCT01860183 Phase 4
40 Efficacy and Safety of a Covered Self-expandable Dual-layered Metallic Mesh Stent (UVENTA) in Ureteral Obstruction Unknown status NCT01788865 Phase 4
41 Steroid Free Immunosuppression or Calcineurin Inhibitor Minimization After Basiliximab Induction Therapy in Kidney Transplantation: Comparison With a Standard Quadruple Immunosuppressive Regimen Unknown status NCT01560572 Phase 4
42 Inspiratory Muscle Training in Patients With End Stage Renal Failure Unknown status NCT01347775 Phase 4
43 Effects of Spironolactone in Dialysis Unknown status NCT01128101 Phase 4
44 Standard Versus Prolonged-release Tacrolimus Monotherapy After Alemtuzumab Induction in Kidney Transplantation Unknown status NCT00807144 Phase 4
45 Efficacy Study of Everolimus on Renal Function in Heart Transplant Recipients With Established Chronic Renal Failure Unknown status NCT00716573 Phase 4
46 Effect of Hydration With Sodium Bicarbonate for Long-Term Clinical Outcomes in Patients With Chronic Kidney Disease Undergoing an Emergent Coronary Procedure Unknown status NCT00716001 Phase 4
47 Simvastatin Effect on End Stage Renal Failure Patients Treated by Peritoneal Dialysis Unknown status NCT00291863 Phase 4
48 Far Infrared Therapy on AV Fistula Flow, Endothelial Function and Echocardiography in ESRD Patients Unknown status NCT01138254 Phase 4
49 Bladder Lavage as Decontamination Method for Asymptomatic Bacteriuria With Uropathogens in Catheterized Patients Unknown status NCT01772875 Phase 4
50 Mineralocorticoid Receptor Antagonist and Kidney Allograft Histology Unknown status NCT01510795 Phase 4

Search NIH Clinical Center for Urinary System Disease

Genetic Tests for Urinary System Disease

Genetic tests related to Urinary System Disease:

id Genetic test Affiliating Genes
1 Abnormality of the Urinary System 29

Anatomical Context for Urinary System Disease

MalaCards organs/tissues related to Urinary System Disease:

39
Kidney, Smooth Muscle

The Foundational Model of Anatomy Ontology organs/tissues related to Urinary System Disease:

18
Kidney

Publications for Urinary System Disease

Variations for Urinary System Disease

Expression for Urinary System Disease

Search GEO for disease gene expression data for Urinary System Disease.

Pathways for Urinary System Disease

Pathways related to Urinary System Disease according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 9.77 FGF23 PTH

GO Terms for Urinary System Disease

Cellular components related to Urinary System Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.9 ACE ALB B2M CRP CST3 KLK3
2 extracellular region GO:0005576 9.77 ACE ALB AVP B2M CRP CST3
3 extracellular space GO:0005615 9.4 ACE ALB AVP B2M CRP CST3
4 slit diaphragm GO:0036057 9.26 NPHS1 NPHS2

Biological processes related to Urinary System Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 apoptotic process GO:0006915 9.8 AVP CST3 EPO KRT20 LCN2 SIX1
2 kidney development GO:0001822 9.61 ACE REN SIX1
3 response to drug GO:0042493 9.55 B2M CST3 LCN2 PTH REN
4 response to nutrient levels GO:0031667 9.43 CST3 LCN2 PTH
5 beta-amyloid metabolic process GO:0050435 9.4 ACE REN
6 angiotensin maturation GO:0002003 9.37 ACE REN
7 excretion GO:0007588 9.13 NPHS1 NPHS2 UMOD
8 cellular protein metabolic process GO:0044267 9.02 ALB B2M CST3 FGF23 KLK3

Molecular functions related to Urinary System Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 endopeptidase activity GO:0004175 8.8 ACE KLK3 REN

Sources for Urinary System Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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