MCID: URN010
MIFTS: 45

Urinary Tract Obstruction malady

Nephrological diseases category

Aliases & Classifications for Urinary Tract Obstruction

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Urinary Tract Obstruction, Aliases & Descriptions:

Name: Urinary Tract Obstruction 9 11 60
Obstructive Uropathy 9 43
 
Urinary Obstruction 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological diseases


External Ids:

Disease Ontology9 DOID:5200
ICD9CM27 599.60, 599.6

Summaries for Urinary Tract Obstruction

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MalaCards based summary: Urinary Tract Obstruction, also known as obstructive uropathy, is related to cystitis and oligohydramnios. An important gene associated with Urinary Tract Obstruction is AQP3 (aquaporin 3 (Gill blood group)), and among its related pathways are Vasopressin-regulated water reabsorption and ErbB4 signaling events. The compounds hgcl2 and hg2+ have been mentioned in the context of this disorder. Affiliated tissues include kidney, testes and prostate, and related mouse phenotypes are integument and vision/eye.

Related Diseases for Urinary Tract Obstruction

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Diseases related to Urinary Tract Obstruction via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 139)
idRelated DiseaseScoreTop Affiliating Genes
1cystitis31.2UMOD
2oligohydramnios30.8ACE
3nephrolithiasis30.4CHRM3, UMOD
4kidney disease30.0UMOD, TGFB1, PTGS2
5adenocarcinoma29.6PTGS2, AQP3, TGFB1, HBEGF, PIK3CA
6prostate cancer29.3HBEGF, TGFB1, PTGS2, PIK3CA
7urethritis10.6
8retroperitoneal fibrosis10.5
9prostatitis10.4
10hydronephrosis10.4
11posterior urethral valves10.4
12diabetes insipidus10.4
13diabetes insipidus, nephrogenic10.3AQP3, AQP2
14vesicoureteral reflux10.3
15ovarian hyperstimulation syndrome10.3
16phimosis10.3
17kashani strom utley syndrome10.3
18split hand urinary anomalies spina bifida10.3
19transient pseudohypoaldosteronism10.3
20idiopathic edema10.2ACE, AQP2
21hypokalemia10.2ACE, AQP2
22nephrosclerosis10.2TGFB1, ACE
23polycystic kidney disease, autosomal dominant10.2ACE, AQP2
24cystic fibrosis10.2UMOD, AQP2, AQP3
25thyroid cancer, anaplastic10.1TGFB1, PIK3CA
26neural tube defects10.1
27renal cell carcinoma10.1
28arthritis10.1
29b-cell lymphomas10.1
30pseudohypoaldosteronism10.1
31renal tubular acidosis10.1
32dyskeratosis congenita10.1
33bacteriuria10.1
34urethral diverticulum10.1
35acute pyelonephritis10.1
36ureterocele10.1
37erdheim-chester disease10.1
38sarcomatoid renal cell carcinoma10.1
39gastroschisis10.1
40amyloidosis10.1
41constipation10.1
42cystic kidney10.1
43endometriosis10.1
44histoplasmosis10.1
45leiomyoma10.1
46neurofibroma10.1
47pyelonephritis10.1
48syndactyly10.1
49tuberculosis10.1
50urethral stricture10.1

Graphical network of the top 20 diseases related to Urinary Tract Obstruction:



Diseases related to urinary tract obstruction

Symptoms for Urinary Tract Obstruction

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Drugs & Therapeutics for Urinary Tract Obstruction

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Drug clinical trials:

Search ClinicalTrials for Urinary Tract Obstruction

Search NIH Clinical Center for Urinary Tract Obstruction

Genetic Tests for Urinary Tract Obstruction

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Anatomical Context for Urinary Tract Obstruction

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MalaCards organs/tissues related to Urinary Tract Obstruction:

31
Kidney, Testes, Prostate, Smooth muscle, Lung, Cervix, Monocytes, B cells, Neutrophil

Animal Models for Urinary Tract Obstruction or affiliated genes

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Publications for Urinary Tract Obstruction

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Articles related to Urinary Tract Obstruction:

(show top 50)    (show all 313)
idTitleAuthorsYear
1
Erdheim-Chester disease: an uncommon cause of upper urinary tract obstruction. (24088590)
2013
2
Fetal lower urinary tract obstruction and its management. (23138754)
2013
3
Urinary tract obstruction in the mouse: the kinetics of distal nephron injury. (23917879)
2013
4
The Percutaneous shunting in Lower Urinary Tract Obstruction (PLUTO) study and randomised controlled trial: evaluation of the effectiveness, cost-effectiveness and acceptability of percutaneous vesicoamniotic shunting for lower urinary tract obstruction. (24331029)
2013
5
Use of inverted fluoroscope's C-arm during endoscopic treatment of urinary tract obstruction in pregnancy: a practicable solution to cut radiation. (20363496)
2010
6
The effect of alpha-blocker treatment on bladder hypoxia inducible factor-1 alpha regulation during lower urinary tract obstruction. (20202240)
2010
7
In utero management of fetal lower urinary tract obstruction with a novel shunt: a landmark development in fetal therapy. (19968590)
2010
8
Fetal lower urinary tract obstruction. (19559326)
2009
9
Aberrant planar cell polarity induced by urinary tract obstruction. (19794107)
2009
10
Prenatal intervention for lower urinary tract obstruction. (19484159)
2009
11
Diffusion-weighted magnetic resonance imaging of urinary epithelial cancer with upper urinary tract obstruction: preliminary results. (19031182)
2008
12
Role of urinary biomarkers in the diagnosis of congenital upper urinary tract obstruction. (19468460)
2008
13
Vesicoamniotic shunting for fetal lower urinary tract obstruction: an overview. (17449853)
2007
14
An unusual case of urinary tract obstruction due to imperforate hymen in an 11-month-old infant. (19675802)
2007
15
Lower urinary tract obstruction in a Mediterranean spur-thighed tortoise (Testudo graeca) with coxofemoral arthritis. (17028253)
2006
16
The GP's role in lower urinary tract obstruction. (15686258)
2005
17
Magnetic resonance urography in the diagnosis of urinary tract obstruction after renal transplantation. (12133293)
2002
18
Role of urinary transforming growth factor-beta1 concentration in the diagnosis of upper urinary tract obstruction in children. (12352362)
2002
19
In utero therapy for lower urinary tract obstruction. (11746151)
2001
20
Urinary tract obstruction. (11245776)
2001
21
Simultaneous upper and lower urinary tract obstruction associated with severe genital prolapse: diagnosis and evaluation with magnetic resonance imaging. (11374515)
2001
22
Perinatal differential diagnosis of cystic kidney disease and urinary tract obstruction: anatomic pathologic, ultrasonographic and genetic findings. (10725570)
2000
23
Elevated bladder urine concentration of transforming growth factor-beta1 correlates with upper urinary tract obstruction in children. (10458426)
1999
24
MR pyelography and conventional MR imaging in urinary tract obstruction. (10080734)
1999
25
Imaging and urinary tract obstruction: forward (and backward). (9437054)
1998
26
MR urography in the evaluation of urinary tract obstruction. (9437058)
1998
27
The impact of renal impairment on the management of patients with lower urinary tract obstruction. (9133785)
1997
28
Indinavir urinary stones as origin of upper urinary tract obstruction. (9444746)
1997
29
Urinary tract obstruction in children. (7563375)
1995
30
Physiopathology of hypernatremia following relief of urinary tract obstruction. (7871935)
1994
31
Haemorrhagic infarction of a prolapsed orthotopic ureterocele causing upper urinary tract obstruction. (7827823)
1994
32
Percutaneous nephrostomy in malignant urinary tract obstruction. (8241936)
1993
33
Re: Why renography can fail in the diagnosis of upper urinary tract obstruction. (8435728)
1993
34
The diagnosis of upper urinary tract obstruction. (2362903)
1990
35
Treatment of urinary tract obstruction by cancer of the prostate. (2674991)
1989
36
Fetal urinary tract obstruction and trisomy 18 mosaicism. A case report. (3285006)
1988
37
The effect of radiopharmaceutical choice on the assessment of the relative renal function in upper urinary tract obstruction. (2838283)
1988
38
The prenatal diagnosis of lower urinary tract obstruction using B scan ultrasound: a case report. (142096)
1977
39
Letter: Constipation: a cause of urinary tract obstruction and infection. (1246799)
1976
40
Sodium excretion after relief of urinary tract obstruction in children. (4856776)
1974
41
Quantitative analysis of the third segment of the renogram and its application for the detection of urinary tract obstruction and renal arterial constriction. (5058031)
1972
42
Intra-renal effects of urinary tract obstruction. (4655919)
1972
43
Fibromuscular hyperplasia of the posterior urethra: a cause for lower urinary tract obstruction in male children. (5058027)
1972
44
Hypernatremia complicating partial urinary-tract obstruction. (5454766)
1970
45
Plastic reconstruction in the treatment of urinary-tract obstruction caused by aberrant renal arteries. (5352294)
1969
46
Pronounced polyuria and natriuresis following surgical relief of urinary tract obstruction. (5943546)
1966
47
Electrolyte balance following relief of chronic urinary tract obstruction. (13836557)
1959
48
The management of hydronephrosis due to upper urinary tract obstruction. (14804202)
1951
49
Aneurysm of the hypogastric artery producing urinary tract obstruction; report of a case. (20295855)
1947
50
Congenital lower urinary tract obstruction; case report. (20279604)
1946

Variations for Urinary Tract Obstruction

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Expression for genes affiliated with Urinary Tract Obstruction

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Search GEO for disease gene expression data for Urinary Tract Obstruction.

Pathways for genes affiliated with Urinary Tract Obstruction

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Pathways related to Urinary Tract Obstruction according to GeneCards Suite gene sharing:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8AQP2, AQP3
29.7PIK3CA, HBEGF
39.7HBEGF, PIK3CA
49.6TGFB1, PIK3CA
59.6TGFB1, PIK3CA
6
Show member pathways
Translation Non genomic rapid action of Androgen Receptor58
9.3TGFB1, HBEGF, PIK3CA
79.3TGFB1, HBEGF, PIK3CA
8
Show member pathways
9.2PIK3CA, HBEGF, CHRM3
9
Show member pathways
9.2TGFB1, ACE
109.0PIK3CA, PTGS2, TGFB1
11
Show member pathways
Transcription Receptor mediated HIF regulation58
Development CNTF receptor signaling58
Class IB PI3K non-lipid kinase events36
ErbB2/ErbB3 signaling events36
Development Growth hormone signaling via PI3K AKT and MAPK cascades58
Translation Regulation activity of EIF258
Regulation of lipid metabolism Insulin signaling generic cascades58
Transcription PPAR Pathway58
Cell adhesion PLAU signaling58
Translation Regulation activity of EIF4F58
9.0TGFB1, PTGS2, PIK3CA
129.0TGFB1, PTGS2, PIK3CA
13
Show member pathways
9.0PIK3CA, PTGS2, TGFB1
14
Show member pathways
8.9CHRM3, PTGS2, PIK3CA
15
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
8.8ACE, TGFB1, PIK3CA
168.8PIK3CA, HBEGF, TGFB1, SLC5A6
17
Show member pathways
8.6PTGS2, TGFB1, ACE

Compounds for genes affiliated with Urinary Tract Obstruction

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Compounds related to Urinary Tract Obstruction according to GeneCards Suite gene sharing:

(show top 50)    (show all 64)
idCompoundScoreTop Affiliating Genes
1hgcl24310.2AQP3, AQP2
2hg2+2810.2AQP2, AQP3
3hcec4310.1PIK3CA, HBEGF
4mercury4310.1AQP3, AQP2
5staurosporin4310.0PIK3CA, HBEGF
6urea43 24 1211.8UMOD, AQP2, AQP3
7nacl439.8UMOD, AQP2, HBEGF
8alginate439.7TGFB1, HBEGF
9tramadol49 43 1211.7CHRM3, PTGS2
10bromodeoxyuridine439.7TGFB1, HBEGF, PIK3CA
11dmso439.6AQP2, TGFB1, PIK3CA
12benazepril43 49 1211.6ACE, TGFB1
13ramipril43 1210.5TGFB1, ACE
14ag 1478439.5PTGS2, HBEGF, PIK3CA
15matrigel439.5TGFB1, HBEGF, PIK3CA
16perindopril43 49 1211.5TGFB1, ACE
17desmopressin43 59 28 1212.5AQP2, PTGS2
18hydrochlorothiazide43 28 49 24 1213.4ACE, AQP2
19polysaccharide439.4HBEGF, TGFB1, UMOD
20amiodarone43 49 28 1212.4TGFB1, ACE
21pdtc439.4PIK3CA, PTGS2, TGFB1
22inositol439.4PIK3CA, CHRM3, SLC5A6
23candesartan43 49 28 1212.4TGFB1, ACE
24bumetanide43 59 28 49 1213.3ACE, PTGS2
25ang ii439.3HBEGF, TGFB1, ACE
26heparin43 28 24 1212.3PIK3CA, HBEGF, CHRM3, UMOD
27adenylate439.2PIK3CA, AQP3, AQP2, CHRM3
28metformin43 49 1211.2ACE, TGFB1, PIK3CA
29etoposide43 49 59 1212.2PIK3CA, PTGS2, TGFB1
30chloride439.2SLC5A6, CHRM3, AQP2, AQP3
31sb 20358043 5910.2TGFB1, PTGS2, HBEGF
32cyclosporin a43 28 5911.1PIK3CA, TGFB1, AQP2, CHRM3
33sildenafil28 43 49 24 1213.1ACE, TGFB1
34pge2439.1AQP2, TGFB1, PTGS2, HBEGF
35pd 98,059439.1PIK3CA, HBEGF, PTGS2, TGFB1
36ly294002439.1TGFB1, PTGS2, HBEGF, PIK3CA
37actinomycin d439.1PIK3CA, HBEGF, PTGS2, TGFB1
38vegf438.9PIK3CA, HBEGF, PTGS2, TGFB1
39aspirin43 49 28 2411.9ACE, TGFB1, PTGS2
40threonine438.8PIK3CA, TGFB1, AQP3, AQP2, CHRM3
41cisplatin43 49 59 1211.7PIK3CA, HBEGF, PTGS2, TGFB1, AQP2
42creatinine438.6TGFB1, AQP3, AQP2, ACE, UMOD
43potassium43 24 1210.4PIK3CA, AQP2, ACE, UMOD, SLC5A6
44sodium43 249.4SLC5A6, UMOD, ACE, AQP2, PIK3CA
45dexamethasone43 49 28 1211.4PIK3CA, HBEGF, PTGS2, TGFB1, AQP3, AQP2
46nitric oxide43 24 1210.4PIK3CA, HBEGF, PTGS2, AQP2, ACE
47norepinephrine43 24 1210.3CHRM3, ACE, SLC5A6
48lipid437.9PIK3CA, HBEGF, AQP2, CHRM3, ACE, SLC5A6
49calcium43 49 24 1210.6PIK3CA, HBEGF, AQP2, CHRM3, ACE, UMOD
50glucose437.3SLC5A6, PIK3CA, HBEGF, AQP3, AQP2, CHRM3

GO Terms for genes affiliated with Urinary Tract Obstruction

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Cellular components related to Urinary Tract Obstruction according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1basolateral plasma membraneGO:00163238.8UMOD, CHRM3, AQP2, AQP3
2extracellular spaceGO:00056158.5UMOD, ACE, TGFB1, HBEGF
3plasma membraneGO:00058866.8PIK3CA, TGFB1, AQP3, AQP2, CHRM3, ACE

Biological processes related to Urinary Tract Obstruction according to GeneCards Suite gene sharing:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1water transportGO:000683310.0AQP2, AQP3
2protein kinase B signalingGO:00434919.8PIK3CA, TGFB1
3response to lithium ionGO:00102269.7PTGS2, AQP2
4excretionGO:00075889.7UMOD, AQP2, AQP3
5response to calcium ionGO:00515929.7AQP2, AQP3
6positive regulation vascular endothelial growth factor productionGO:00105759.6TGFB1, PTGS2
7positive regulation of peptidyl-serine phosphorylationGO:00331389.6PIK3CA, TGFB1
8positive regulation of smooth muscle cell proliferationGO:00486619.6PTGS2, HBEGF
9positive regulation of smooth muscle contractionGO:00459879.6CHRM3, PTGS2
10negative regulation of cell cycleGO:00457869.5TGFB1, PTGS2
11epidermal growth factor receptor signaling pathwayGO:00071739.5TGFB1, HBEGF, PIK3CA
12mononuclear cell proliferationGO:00329439.5ACE, TGFB1
13response to vitamin DGO:00332809.4AQP3, TGFB1, PTGS2
14regulation of blood pressureGO:00082179.0ACE, PTGS2
15negative regulation of cell proliferationGO:00082858.8UMOD, TGFB1, PTGS2

Molecular functions related to Urinary Tract Obstruction according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1drug bindingGO:00081449.1ACE, CHRM3

Products for genes affiliated with Urinary Tract Obstruction

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Sources for Urinary Tract Obstruction

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet