MCID: URN010
MIFTS: 55

Urinary Tract Obstruction malady

Nephrological diseases category

Summaries for Urinary Tract Obstruction

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63Wikipedia, 32MalaCards
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Wikipedia:63 Urinary tract obstruction is a urologic disease consisting of a decrease in the free passage of urine... more...

MalaCards: Urinary Tract Obstruction, also known as obstructive uropathy, is related to ureteral obstruction and prostatitis. An important gene associated with Urinary Tract Obstruction is HBEGF (heparin-binding EGF-like growth factor), and among its related pathways are Passive Transport by Aquaporins and Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics. The compounds estrogen and hgcl2 have been mentioned in the context of this disorder. Affiliated tissues include kidney, prostate and testes, and related mouse phenotypes are adipose tissue and respiratory system.

Aliases & Classifications for Urinary Tract Obstruction

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8Disease Ontology, 10DISEASES, 60UMLS, 44Novoseek, 56SNOMED-CT, 27ICD9CM, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological diseases


Aliases & Descriptions:

urinary tract obstruction 8 10 60
obstructive uropathy 8 44
obstructive uropathy, unspecified 8
urinary obstruction, unspecified 8
urinary obstruction unspecified 8
obstructive uropathy nos 8
urinary obstruction 8


External Ids:

Disease Ontology8 DOID:5200
ICD9CM27 599.6, 599.60
ICD1025 N13.9, N20.9

Related Diseases for Urinary Tract Obstruction

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Urinary Tract Obstruction via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 148)
idRelated DiseaseScoreTop Affiliating Genes
1ureteral obstruction30.6TGFB1
2prostatitis30.6KLK3
3diabetes insipidus30.4AQP2
4vesicoureteral reflux30.3UMOD
5leiomyoma30.1HBEGF
6pyelonephritis30.1B2M, UMOD
7nephrolithiasis30.1CHRM3, UMOD
8hypertension30.1FBXL20, ACE, TGFB1
9ovarian cancer30.1PIK3CA, HBEGF, TGFB1
10arthritis30.1TGFB1, PTGS2, B2M
11prostate cancer30.1KLK3, PIK3CA, HBEGF, PTGS2, TGFB1
12adenocarcinoma30.1KLK3, PIK3CA, HBEGF, PTGS2, AQP3, TGFB1
13oligohydramnios30.1ACE
14sarcoidosis30.1ACE
15anuria30.1ACE
16vascular disease29.8PTGS2
17chronic pyelonephritis29.8B2M, UMOD
18urethritis10.5
19urethral obstruction10.5
20hydronephrosis10.3
21nephrogenic diabetes insipidus10.3
22kashani strom utley syndrome10.3
23renal artery obstruction10.2
24cystitis10.2
25ovarian hyperstimulation syndrome10.2
26phimosis10.2
27split hand urinary anomalies spina bifida10.2
28retroperitoneal fibrosis10.2
29bacteriuria10.1
30dyskeratosis congenita10.1
31erdheim-chester disease10.1
32sarcomatoid renal cell carcinoma10.1
33pseudohypoaldosteronism10.1
34urethral syndrome10.1
35syndactyly10.1
36gastroschisis10.1
37acute pyelonephritis10.1
38urethral diverticulum10.1
39ureterocele10.1
40renal tuberculosis10.1
41renal tubular acidosis10.1
42amyloidosis10.1
43constipation10.1
44cystic kidney10.1
45endometriosis10.1
46histoplasmosis10.1
47kidney disease10.1
48neurofibroma10.1
49renal cell carcinoma10.1
50tuberculosis10.1

Graphical network of the top 20 diseases related to Urinary Tract Obstruction:



Diseases related to urinary tract obstruction

Clinical Features for Urinary Tract Obstruction

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Drugs & Therapeutics for Urinary Tract Obstruction

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Urinary Tract Obstruction

Drug clinical trials:

Search ClinicalTrials for Urinary Tract Obstruction

Search NIH Clinical Center for Urinary Tract Obstruction

Search CenterWatch for Urinary Tract Obstruction

Genetic Tests for Urinary Tract Obstruction

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Anatomical Context for Urinary Tract Obstruction

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Sources:
32MalaCards
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MalaCards organs/tissues related to Urinary Tract Obstruction:

32
Kidney, Prostate, Testes, Lung, Smooth muscle, Cervix, Monocytes, B cells, Fetal lung

Animal Models for Urinary Tract Obstruction or affiliated genes

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36MGI
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Publications for Urinary Tract Obstruction

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50PubMed
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Articles related to Urinary Tract Obstruction:

(show top 50)    (show all 338)
idTitleAuthorsYear
1
Clinical character of cystitis glandularis accompanied with upper urinary tract obstruction. (24282462)
2013
2
Urinary tract infection associated with conditions causing urinary tract obstruction and stasis, excluding urolithiasis and neuropathic bladder. (21720861)
2012
3
Possible association between hyperthyroidism in pregnant women and obstructive congenital abnormalities of urinary tract in their offspring--a population-based case-control study. (20504076)
2011
4
Fetal cystoscopy for severe lower urinary tract obstruction--initial experience of a single center. (19967749)
2010
5
Primary bladder amyloidosis--case report of a patient with delayed upper urinary tract obstruction 3 years after the diagnosis. (20132089)
2010
6
Phenotypic transition of the collecting duct epithelium in congenital urinary tract obstruction. (20037736)
2010
7
Role of urinary biomarkers in the diagnosis of congenital upper urinary tract obstruction. (19468460)
2008
8
Congenital urinary tract obstruction. (17904905)
2008
9
Vesicoamniotic shunting for fetal lower urinary tract obstruction: an overview. (17449853)
2007
10
Giant pelvic solitary fibrous tumor obstructing intestinal and urinary tract: a case report and literature review. (17521003)
2007
11
The GP's role in lower urinary tract obstruction. (15686258)
2005
12
Long-term outcomes in children treated by prenatal vesicoamniotic shunting for lower urinary tract obstruction. (16135579)
2005
13
Prenatal bladder drainage in the management of fetal lower urinary tract obstruction: a systematic review and meta-analysis. (12907115)
2003
14
Role of urinary transforming growth factor-beta1 concentration in the diagnosis of upper urinary tract obstruction in children. (12352362)
2002
15
Initial pathological events in renal dysplasia with urinary tract obstruction in utero. (11710644)
2001
16
Patterns of congenital lower urinary tract obstructive uropathy: relation to abnormal prostate and bladder development and the prune belly syndrome. (11779049)
2001
17
Elevated bladder urine concentration of transforming growth factor-beta1 correlates with upper urinary tract obstruction in children. (10458426)
1999
18
A prospective randomized trial comparing 2 diuresis renography techniques for evaluation of suspected upper urinary tract obstruction in children. (9554395)
1998
19
Urinary tract obstruction in children. (7563375)
1995
20
Uterine prolapse and urinary tract obstruction. (8644554)
1995
21
Haemorrhagic infarction of a prolapsed orthotopic ureterocele causing upper urinary tract obstruction. (7827823)
1994
22
Disseminated histoplasmosis presenting as urinary tract obstruction in a renal transplant recipient. (8154500)
1994
23
Labial fusion causing upper urinary tract obstruction. (8367931)
1993
24
Contemporary concepts for imaging urinary tract obstruction. (1615578)
1992
25
Complete prenatal urinary tract obstruction caused by congenital megalourethra. (1313834)
1992
26
Treatment of urinary tract obstruction by cancer of the prostate. (2674991)
1989
27
Bladder outflow tract obstruction and urinary retention from benign prostatic hypertrophy treated by balloon dilatation. (2483354)
1989
28
Urinary tract obstruction secondary to presacral teratoma: a missed diagnosis. (2677411)
1989
29
Non-dilated urinary tract obstruction: the importance of the plain abdominal X-ray. (2510074)
1989
30
Volume expansion diuretic renal scan in urinary tract obstruction. (3553462)
1987
31
Diuretic scintigraphy in diagnosis and treatment of urinary tract obstruction. (3515872)
1986
32
The diagnosis of upper urinary tract obstruction in children: comparison of diuresis renography and pressure flow studies. (3884844)
1985
33
Evaluation and management of upper urinary tract obstruction in infancy and childhood. (3883619)
1985
34
Diuresis renography in equivocal urinary tract obstruction. (6697111)
1984
35
The varied sonographic appearance of the urinary tract in the fetus and newborn with urethral obstruction. (7100473)
1982
36
Pleural effusion associated with urinary tract obstruction: support for a hypothesis. (7314037)
1981
37
Sodium excretion after relief of urinary tract obstruction in children. (4856776)
1974
38
Quantitative analysis of the third segment of the renogram and its application for the detection of urinary tract obstruction and renal arterial constriction. (5058031)
1972
39
Drip infusion pyelography with delayed drainage films in urinary tract obstruction. (4502571)
1972
40
Urinary tract obstruction in causation of infection, stone formation and renal failure. (4643956)
1972
41
Modern concepts of lower urinary tract obstruction in pediatric patients. (5413382)
1970
42
Studies on the mechanism of diuresis after relief of urinary-tract obstruction. (6015587)
1967
43
Observations on the effect of lower urinary tract obstruction. A report on urethral valvular obstruction in 17 Central African children. (6074275)
1967
44
Experimental descending Escherichia coli urinary tract infection: influence of specific immunization and chronic bladder neck obstruction. (5326169)
1966
45
Lower urinary tract obstruction in normal male children. Early detection by urinary diary. (5846688)
1965
46
Changing concepts in lower urinary-tract obstruction in children. (13711036)
1961
47
Renal function in water-losing syndrome due to lower urinary tract obstruction before and after treatment. (13636859)
1959
48
Urinary tract obstruction: what has been learned about it, and what is still to be learned. (13564595)
1958
49
An abnormality in renal function resulting from urinary tract obstruction. (13469826)
1957
50
Treatment of urinary tract obstruction due to sulfonamide crystals with special reference to lumbar sympathetic block. (20290734)
1946

Genetic Variations for Urinary Tract Obstruction

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Expression for genes affiliated with Urinary Tract Obstruction

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Urinary Tract Obstruction

Search GEO for disease gene expression data for Urinary Tract Obstruction.

Pathways for genes affiliated with Urinary Tract Obstruction

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Sources:
53Reactome, 49PharmGKB, 37NCBI BioSystems Database, 12EMD Millipore, 29KEGG
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Pathways related to Urinary Tract Obstruction according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9AQP2, AQP3
2
Hide members
9.8TGFB1, ACE
3
Transcription Androgen Receptor nuclear signaling
Hide members
9.1TGFB1, HBEGF, PIK3CA, KLK3
48.9KLK3, PIK3CA, PTGS2, TGFB1

Compounds for genes affiliated with Urinary Tract Obstruction

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 49PharmGKB, 59Tocris Bioscience, 24HMDB, 2BitterDB
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Compounds related to Urinary Tract Obstruction according to GeneCards/GeneDecks:

(show top 50)    (show all 62)
idCompoundScoreTop Affiliating Genes
1estrogen4410.5KLK3
2hgcl24410.3AQP2, AQP3
3hg2+2810.3AQP2, AQP3
4mannitol44 1111.2AQP3, HBEGF
5benazepril44 1111.1ACE, TGFB1
6an 694410.1ACE, B2M
7ang ii449.9ACE, TGFB1, HBEGF
8isradipine44 28 1111.9B2M, ACE
9tramadol44 49 1111.9CHRM3, PTGS2
10candesartan44 28 1111.9KLK3, ACE, TGFB1
11pge2449.8TGFB1, AQP2, PTGS2
12exisulind449.8PTGS2, KLK3
13desmopressin44 59 28 1112.7AQP2, PTGS2, B2M
14urea44 11 2411.7AQP2, AQP3, B2M, UMOD
15metformin44 49 1111.7TGFB1, ACE, PIK3CA
16ramipril44 1110.7ACE, TGFB1
176-ketoprostaglandin f1alpha449.6B2M, PTGS2
18ag 1478449.6PIK3CA, HBEGF, PTGS2
19potassium44 11 2411.6AQP2, SLC5A6, ACE
20thalidomide44 49 59 1112.6PTGS2, B2M, KLK3
21pdtc449.6PIK3CA, PTGS2, TGFB1
22docetaxel44 49 59 1112.5PIK3CA, TGFB1, KLK3
23gefitinib44 49 1111.5PIK3CA, KLK3, PTGS2
24nifedipine44 49 28 1112.5B2M, TGFB1, ACE
25bromodeoxyuridine449.5HBEGF, PIK3CA, TGFB1
26paraffin449.5KLK3, TGFB1, HBEGF, B2M
27creatinine449.4AQP3, UMOD, TGFB1, ACE, AQP2
28polysaccharide449.4TGFB1, KLK3, B2M, UMOD, HBEGF
29sodium44 2410.4SLC5A6, AQP2, ACE, UMOD
30doxorubicin44 49 1111.3KLK3, TGFB1, B2M, PIK3CA
31aspirin44 49 28 2412.3PTGS2, ACE, KLK3, TGFB1
32biotin44 11 2411.3AQP2, B2M, SLC5A6, KLK3
33pd 98,059449.3HBEGF, PIK3CA, PTGS2, TGFB1
34ly294002449.3TGFB1, PTGS2, HBEGF, PIK3CA
35actinomycin d449.3TGFB1, PTGS2, PIK3CA, HBEGF
36etoposide44 49 59 1112.2KLK3, PIK3CA, TGFB1, PTGS2
37cyclosporin a44 28 5911.2AQP2, B2M, PIK3CA, TGFB1, CHRM3
38threonine449.1AQP2, AQP3, CHRM3, TGFB1, PIK3CA
39cycloheximide449.1TGFB1, PTGS2, HBEGF, B2M, KLK3
40genistein44 28 59 2 11 2414.1PIK3CA, B2M, HBEGF, PTGS2
41inositol449.1CHRM3, SLC5A6, PIK3CA
42chloride449.1AQP2, AQP3, SLC5A6, CHRM3, B2M
43nitric oxide44 11 2410.9AQP2, PTGS2, ACE, PIK3CA, HBEGF
44cisplatin44 49 59 1111.8PIK3CA, TGFB1, AQP2, PTGS2, HBEGF, B2M
45lactate448.7TGFB1, B2M, PIK3CA, KLK3
46vegf448.7KLK3, TGFB1, PTGS2, HBEGF, B2M, PIK3CA
47dexamethasone44 49 28 1111.5KLK3, PIK3CA, HBEGF, PTGS2, AQP3, AQP2
48lipid448.5ACE, SLC5A6, CHRM3, PIK3CA, AQP2, HBEGF
49calcium44 49 11 2410.9AQP2, ACE, CHRM3, SLC5A6, HBEGF, B2M
50glucose447.7CHRM3, UMOD, PIK3CA, B2M, HBEGF, SLC5A6

GO Terms for genes affiliated with Urinary Tract Obstruction

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16Gene Ontology
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Cellular components related to Urinary Tract Obstruction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1basolateral plasma membraneGO:0163239.1AQP2, AQP3, CHRM3, UMOD
2extracellular spaceGO:0056158.9TGFB1, ACE, HBEGF, B2M, UMOD

Biological processes related to Urinary Tract Obstruction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mononuclear cell proliferationGO:0329439.8TGFB1, ACE
2excretionGO:0075889.7AQP2, UMOD, AQP3
3positive regulation vascular endothelial growth factor productionGO:0105759.7PTGS2, TGFB1
4response to lithium ionGO:0102269.6PTGS2, AQP2
5response to vitamin DGO:0332809.5PTGS2, AQP3, TGFB1
6positive regulation of smooth muscle contractionGO:0459879.3PTGS2, CHRM3

Products for genes affiliated with Urinary Tract Obstruction

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Urinary Tract Obstruction

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet