MCID: URN010
MIFTS: 57

Urinary Tract Obstruction malady

Nephrological diseases category

Summaries for Urinary Tract Obstruction

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66Wikipedia, 34MalaCards
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Wikipedia:66 Urinary tract obstruction is a urologic disease consisting of a decrease in the free passage of urine... more...

MalaCards: Urinary Tract Obstruction, also known as obstructive uropathy, is related to nephrogenic diabetes insipidus and cystitis. An important gene associated with Urinary Tract Obstruction is AQP3 (aquaporin 3 (Gill blood group)), and among its related pathways are Vasopressin-regulated water reabsorption and ErbB4 signaling events. The compounds hgcl2 and hg2+ have been mentioned in the context of this disorder. Affiliated tissues include kidney, testes and prostate, and related mouse phenotypes are integument and vision/eye.

Aliases & Classifications for Urinary Tract Obstruction

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Sources:
9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 28ICD9CM, 41NCIt, 59SNOMED-CT, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological diseases


Aliases & Descriptions:

urinary tract obstruction 9 11 63
obstructive uropathy 9 46
obstructive uropathy, unspecified 9
urinary obstruction, unspecified 9
urinary obstruction unspecified 9
obstructive uropathy nos 9
urinary obstruction 9


External Ids:

Disease Ontology9 DOID:5200
ICD9CM28 599.6, 599.60
ICD1026 N13.9, N20.9

Related Diseases for Urinary Tract Obstruction

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18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Urinary Tract Obstruction:



Diseases related to urinary tract obstruction

Symptoms for Urinary Tract Obstruction

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Drugs & Therapeutics for Urinary Tract Obstruction

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Urinary Tract Obstruction

Drug clinical trials:

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Search NIH Clinical Center for Urinary Tract Obstruction

Search CenterWatch for Urinary Tract Obstruction

Genetic Tests for Urinary Tract Obstruction

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Anatomical Context for Urinary Tract Obstruction

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34MalaCards
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MalaCards organs/tissues related to Urinary Tract Obstruction:

34
Kidney, Testes, Prostate, Smooth muscle, Lung, Cervix, Monocytes, B cells

Animal Models for Urinary Tract Obstruction or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Urinary Tract Obstruction:

38 (show all 18)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.3PIK3CA, HBEGF, PTGS2, TGFB1, AQP2
2MP:00053918.3PIK3CA, PTGS2, TGFB1, AQP3, CHRM3
3MP:00053698.2CHRM3, TGFB1, PTGS2, HBEGF, PIK3CA
4MP:00053818.2SLC5A6, CHRM3, AQP3, TGFB1, PTGS2
5MP:00020068.2ACE, TGFB1, PTGS2, PIK3CA
6MP:00053888.0HBEGF, PTGS2, TGFB1, AQP3, CHRM3, SLC5A6
7MP:00053707.7PTGS2, TGFB1, CHRM3, ACE, SLC5A6
8MP:00053757.6PIK3CA, PTGS2, TGFB1, CHRM3, ACE, UMOD
9MP:00036317.5PIK3CA, HBEGF, PTGS2, TGFB1, CHRM3, SLC5A6
10MP:00053897.5PIK3CA, PTGS2, TGFB1, AQP2, ACE
11MP:00053797.3PIK3CA, PTGS2, TGFB1, CHRM3, ACE, SLC5A6
12MP:00053877.2PIK3CA, PTGS2, TGFB1, AQP3, ACE, UMOD
13MP:00107686.9PIK3CA, HBEGF, PTGS2, TGFB1, AQP3, AQP2
14MP:00053676.8PTGS2, TGFB1, AQP3, AQP2, CHRM3, ACE
15MP:00053856.8PIK3CA, HBEGF, PTGS2, TGFB1, AQP3, CHRM3
16MP:00053866.4PIK3CA, HBEGF, PTGS2, TGFB1, AQP3, AQP2
17MP:00053786.1SLC5A6, PIK3CA, HBEGF, PTGS2, TGFB1, AQP3
18MP:00053766.1PIK3CA, HBEGF, PTGS2, TGFB1, AQP3, AQP2

Publications for Urinary Tract Obstruction

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Sources:
53PubMed
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Articles related to Urinary Tract Obstruction:

(show top 50)    (show all 307)
idTitleAuthorsYear
1
Erdheim-Chester disease: an uncommon cause of upper urinary tract obstruction. (24088590)
2013
2
Fetal lower urinary tract obstruction and its management. (23138754)
2013
3
Urinary tract obstruction in the mouse: the kinetics of distal nephron injury. (23917879)
2013
4
The Percutaneous shunting in Lower Urinary Tract Obstruction (PLUTO) study and randomised controlled trial: evaluation of the effectiveness, cost-effectiveness and acceptability of percutaneous vesicoamniotic shunting for lower urinary tract obstruction. (24331029)
2013
5
Use of inverted fluoroscope's C-arm during endoscopic treatment of urinary tract obstruction in pregnancy: a practicable solution to cut radiation. (20363496)
2010
6
The effect of alpha-blocker treatment on bladder hypoxia inducible factor-1 alpha regulation during lower urinary tract obstruction. (20202240)
2010
7
In utero management of fetal lower urinary tract obstruction with a novel shunt: a landmark development in fetal therapy. (19968590)
2010
8
Fetal lower urinary tract obstruction. (19559326)
2009
9
Aberrant planar cell polarity induced by urinary tract obstruction. (19794107)
2009
10
Prenatal intervention for lower urinary tract obstruction. (19484159)
2009
11
Diffusion-weighted magnetic resonance imaging of urinary epithelial cancer with upper urinary tract obstruction: preliminary results. (19031182)
2008
12
Role of urinary biomarkers in the diagnosis of congenital upper urinary tract obstruction. (19468460)
2008
13
Vesicoamniotic shunting for fetal lower urinary tract obstruction: an overview. (17449853)
2007
14
An unusual case of urinary tract obstruction due to imperforate hymen in an 11-month-old infant. (19675802)
2007
15
Lower urinary tract obstruction in a Mediterranean spur-thighed tortoise (Testudo graeca) with coxofemoral arthritis. (17028253)
2006
16
The GP's role in lower urinary tract obstruction. (15686258)
2005
17
Magnetic resonance urography in the diagnosis of urinary tract obstruction after renal transplantation. (12133293)
2002
18
Role of urinary transforming growth factor-beta1 concentration in the diagnosis of upper urinary tract obstruction in children. (12352362)
2002
19
In utero therapy for lower urinary tract obstruction. (11746151)
2001
20
Urinary tract obstruction. (11245776)
2001
21
Simultaneous upper and lower urinary tract obstruction associated with severe genital prolapse: diagnosis and evaluation with magnetic resonance imaging. (11374515)
2001
22
Perinatal differential diagnosis of cystic kidney disease and urinary tract obstruction: anatomic pathologic, ultrasonographic and genetic findings. (10725570)
2000
23
Elevated bladder urine concentration of transforming growth factor-beta1 correlates with upper urinary tract obstruction in children. (10458426)
1999
24
MR pyelography and conventional MR imaging in urinary tract obstruction. (10080734)
1999
25
Imaging and urinary tract obstruction: forward (and backward). (9437054)
1998
26
MR urography in the evaluation of urinary tract obstruction. (9437058)
1998
27
The impact of renal impairment on the management of patients with lower urinary tract obstruction. (9133785)
1997
28
Indinavir urinary stones as origin of upper urinary tract obstruction. (9444746)
1997
29
Urinary tract obstruction in children. (7563375)
1995
30
Physiopathology of hypernatremia following relief of urinary tract obstruction. (7871935)
1994
31
Haemorrhagic infarction of a prolapsed orthotopic ureterocele causing upper urinary tract obstruction. (7827823)
1994
32
Percutaneous nephrostomy in malignant urinary tract obstruction. (8241936)
1993
33
Re: Why renography can fail in the diagnosis of upper urinary tract obstruction. (8435728)
1993
34
The diagnosis of upper urinary tract obstruction. (2362903)
1990
35
Treatment of urinary tract obstruction by cancer of the prostate. (2674991)
1989
36
Fetal urinary tract obstruction and trisomy 18 mosaicism. A case report. (3285006)
1988
37
The effect of radiopharmaceutical choice on the assessment of the relative renal function in upper urinary tract obstruction. (2838283)
1988
38
The prenatal diagnosis of lower urinary tract obstruction using B scan ultrasound: a case report. (142096)
1977
39
Letter: Constipation: a cause of urinary tract obstruction and infection. (1246799)
1976
40
Sodium excretion after relief of urinary tract obstruction in children. (4856776)
1974
41
Quantitative analysis of the third segment of the renogram and its application for the detection of urinary tract obstruction and renal arterial constriction. (5058031)
1972
42
Intra-renal effects of urinary tract obstruction. (4655919)
1972
43
Fibromuscular hyperplasia of the posterior urethra: a cause for lower urinary tract obstruction in male children. (5058027)
1972
44
Hypernatremia complicating partial urinary-tract obstruction. (5454766)
1970
45
Plastic reconstruction in the treatment of urinary-tract obstruction caused by aberrant renal arteries. (5352294)
1969
46
Pronounced polyuria and natriuresis following surgical relief of urinary tract obstruction. (5943546)
1966
47
Electrolyte balance following relief of chronic urinary tract obstruction. (13836557)
1959
48
The management of hydronephrosis due to upper urinary tract obstruction. (14804202)
1951
49
Aneurysm of the hypogastric artery producing urinary tract obstruction; report of a case. (20295855)
1947
50
Congenital lower urinary tract obstruction; case report. (20279604)
1946

Variations for Urinary Tract Obstruction

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Expression for genes affiliated with Urinary Tract Obstruction

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Urinary Tract Obstruction

Search GEO for disease gene expression data for Urinary Tract Obstruction.

Pathways for genes affiliated with Urinary Tract Obstruction

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Sources:
51PathCards, 31KEGG, 39NCBI BioSystems Database, 61Thomson Reuters, 56Reactome, 52PharmGKB, 54QIAGEN
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Pathways related to Urinary Tract Obstruction according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8AQP2, AQP3
29.7PIK3CA, HBEGF
39.7HBEGF, PIK3CA
49.6TGFB1, PIK3CA
59.6TGFB1, PIK3CA
6
Show member pathways
Translation Non genomic rapid action of Androgen Receptor61
9.3TGFB1, HBEGF, PIK3CA
79.3TGFB1, HBEGF, PIK3CA
8
Show member pathways
9.2PIK3CA, HBEGF, CHRM3
9
Show member pathways
9.2TGFB1, ACE
109.0PIK3CA, PTGS2, TGFB1
11
Show member pathways
Transcription Receptor mediated HIF regulation61
Development CNTF receptor signaling61
Class IB PI3K non-lipid kinase events39
ErbB2/ErbB3 signaling events39
Development Growth hormone signaling via PI3K AKT and MAPK cascades61
Translation Regulation activity of EIF261
Regulation of lipid metabolism Insulin signaling generic cascades61
Transcription PPAR Pathway61
Cell adhesion PLAU signaling61
Translation Regulation activity of EIF4F61
9.0TGFB1, PTGS2, PIK3CA
129.0TGFB1, PTGS2, PIK3CA
13
Show member pathways
9.0PIK3CA, PTGS2, TGFB1
14
Show member pathways
8.9CHRM3, PTGS2, PIK3CA
15
Show member pathways
Toll-like receptor signaling pathway39
Regulation of toll-like receptor signaling pathway39
8.8ACE, TGFB1, PIK3CA
168.8PIK3CA, HBEGF, TGFB1, SLC5A6
17
Show member pathways
8.6PTGS2, TGFB1, ACE

Compounds for genes affiliated with Urinary Tract Obstruction

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Sources:
46Novoseek, 30IUPHAR, 25HMDB, 12DrugBank, 52PharmGKB, 62Tocris Bioscience
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Compounds related to Urinary Tract Obstruction according to GeneCards/GeneDecks:

(show top 50)    (show all 64)
idCompoundScoreTop Affiliating Genes
1hgcl24610.2AQP3, AQP2
2hg2+3010.2AQP2, AQP3
3hcec4610.1PIK3CA, HBEGF
4mercury4610.1AQP3, AQP2
5staurosporin4610.0PIK3CA, HBEGF
6urea46 25 1211.8UMOD, AQP2, AQP3
7nacl469.8UMOD, AQP2, HBEGF
8alginate469.7TGFB1, HBEGF
9tramadol52 46 1211.7CHRM3, PTGS2
10bromodeoxyuridine469.7TGFB1, HBEGF, PIK3CA
11dmso469.6AQP2, TGFB1, PIK3CA
12benazepril46 52 1211.6ACE, TGFB1
13ramipril46 1210.5TGFB1, ACE
14ag 1478469.5PTGS2, HBEGF, PIK3CA
15matrigel469.5TGFB1, HBEGF, PIK3CA
16perindopril46 52 1211.5TGFB1, ACE
17desmopressin46 62 30 1212.5AQP2, PTGS2
18hydrochlorothiazide46 30 52 25 1213.4ACE, AQP2
19polysaccharide469.4HBEGF, TGFB1, UMOD
20amiodarone46 52 30 1212.4TGFB1, ACE
21pdtc469.4PIK3CA, PTGS2, TGFB1
22inositol469.4PIK3CA, CHRM3, SLC5A6
23candesartan46 52 30 1212.4TGFB1, ACE
24bumetanide46 62 30 52 1213.3ACE, PTGS2
25ang ii469.3HBEGF, TGFB1, ACE
26heparin46 30 25 1212.3PIK3CA, HBEGF, CHRM3, UMOD
27adenylate469.2PIK3CA, AQP3, AQP2, CHRM3
28metformin46 52 1211.2ACE, TGFB1, PIK3CA
29etoposide46 52 62 1212.2PIK3CA, PTGS2, TGFB1
30chloride469.2SLC5A6, CHRM3, AQP2, AQP3
31sb 20358046 6210.2TGFB1, PTGS2, HBEGF
32cyclosporin a46 30 6211.1PIK3CA, TGFB1, AQP2, CHRM3
33sildenafil30 46 52 25 1213.1ACE, TGFB1
34pge2469.1AQP2, TGFB1, PTGS2, HBEGF
35pd 98,059469.1PIK3CA, HBEGF, PTGS2, TGFB1
36ly294002469.1TGFB1, PTGS2, HBEGF, PIK3CA
37actinomycin d469.1PIK3CA, HBEGF, PTGS2, TGFB1
38vegf468.9PIK3CA, HBEGF, PTGS2, TGFB1
39aspirin46 52 30 2511.9ACE, TGFB1, PTGS2
40threonine468.8PIK3CA, TGFB1, AQP3, AQP2, CHRM3
41cisplatin46 52 62 1211.7PIK3CA, HBEGF, PTGS2, TGFB1, AQP2
42creatinine468.6TGFB1, AQP3, AQP2, ACE, UMOD
43potassium46 25 1210.4PIK3CA, AQP2, ACE, UMOD, SLC5A6
44sodium46 259.4SLC5A6, UMOD, ACE, AQP2, PIK3CA
45dexamethasone46 52 30 1211.4PIK3CA, HBEGF, PTGS2, TGFB1, AQP3, AQP2
46nitric oxide46 25 1210.4PIK3CA, HBEGF, PTGS2, AQP2, ACE
47norepinephrine46 25 1210.3CHRM3, ACE, SLC5A6
48lipid467.9PIK3CA, HBEGF, AQP2, CHRM3, ACE, SLC5A6
49calcium46 52 25 1210.6PIK3CA, HBEGF, AQP2, CHRM3, ACE, UMOD
50glucose467.3SLC5A6, PIK3CA, HBEGF, AQP3, AQP2, CHRM3

GO Terms for genes affiliated with Urinary Tract Obstruction

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17Gene Ontology
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Cellular components related to Urinary Tract Obstruction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1basolateral plasma membraneGO:0163238.8UMOD, CHRM3, AQP2, AQP3
2extracellular spaceGO:0056158.5UMOD, ACE, TGFB1, HBEGF
3plasma membraneGO:0058866.8PIK3CA, TGFB1, AQP3, AQP2, CHRM3, ACE

Biological processes related to Urinary Tract Obstruction according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1water transportGO:00683310.0AQP2, AQP3
2protein kinase B signalingGO:0434919.8PIK3CA, TGFB1
3response to lithium ionGO:0102269.7PTGS2, AQP2
4excretionGO:0075889.7UMOD, AQP2, AQP3
5response to calcium ionGO:0515929.7AQP2, AQP3
6positive regulation vascular endothelial growth factor productionGO:0105759.6TGFB1, PTGS2
7positive regulation of peptidyl-serine phosphorylationGO:0331389.6PIK3CA, TGFB1
8positive regulation of smooth muscle cell proliferationGO:0486619.6PTGS2, HBEGF
9positive regulation of smooth muscle contractionGO:0459879.6CHRM3, PTGS2
10negative regulation of cell cycleGO:0457869.5TGFB1, PTGS2
11epidermal growth factor receptor signaling pathwayGO:0071739.5TGFB1, HBEGF, PIK3CA
12mononuclear cell proliferationGO:0329439.5ACE, TGFB1
13response to vitamin DGO:0332809.4AQP3, TGFB1, PTGS2
14regulation of blood pressureGO:0082179.0ACE, PTGS2
15negative regulation of cell proliferationGO:0082858.8UMOD, TGFB1, PTGS2

Molecular functions related to Urinary Tract Obstruction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1drug bindingGO:0081449.1ACE, CHRM3

Products for genes affiliated with Urinary Tract Obstruction

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  • Antibodies
  • Proteins
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Sources for Urinary Tract Obstruction

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet