MCID: URN010
MIFTS: 57

Urinary Tract Obstruction malady

Nephrological diseases category
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Summaries for Urinary Tract Obstruction

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65Wikipedia, 33MalaCards
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Wikipedia:65 Urinary tract obstruction is a urologic disease consisting of a decrease in the free passage of urine... more...

MalaCards: Urinary Tract Obstruction, also known as obstructive uropathy, is related to nephrogenic diabetes insipidus and cystitis. An important gene associated with Urinary Tract Obstruction is AQP3 (aquaporin 3 (Gill blood group)), and among its related pathways are Vasopressin-regulated water reabsorption and ErbB4 signaling events. The compounds hgcl2 and hg2+ have been mentioned in the context of this disorder. Affiliated tissues include kidney, testes and prostate, and related mouse phenotypes are integument and vision/eye.

Aliases & Classifications for Urinary Tract Obstruction

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8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 27ICD9CM, 40NCIt, 58SNOMED-CT, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological diseases


Aliases & Descriptions:

urinary tract obstruction 8 10 62
obstructive uropathy 8 45
obstructive uropathy, unspecified 8
urinary obstruction, unspecified 8
urinary obstruction unspecified 8
obstructive uropathy nos 8
urinary obstruction 8


External Ids:

Disease Ontology8 DOID:5200
ICD9CM27 599.6, 599.60
ICD1025 N13.9, N20.9

Related Diseases for Urinary Tract Obstruction

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Urinary Tract Obstruction:



Diseases related to urinary tract obstruction

Symptoms for Urinary Tract Obstruction

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Drugs & Therapeutics for Urinary Tract Obstruction

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Urinary Tract Obstruction

Search NIH Clinical Center for Urinary Tract Obstruction

Genetic Tests for Urinary Tract Obstruction

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Anatomical Context for Urinary Tract Obstruction

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33MalaCards
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MalaCards organs/tissues related to Urinary Tract Obstruction:

33
Kidney, Testes, Prostate, Smooth muscle, Lung, Cervix, Monocytes, B cells

Animal Models for Urinary Tract Obstruction or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Urinary Tract Obstruction:

37 (show all 18)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.3PIK3CA, HBEGF, PTGS2, TGFB1, AQP2
2MP:00053918.3PIK3CA, PTGS2, TGFB1, AQP3, CHRM3
3MP:00053698.2CHRM3, TGFB1, PTGS2, HBEGF, PIK3CA
4MP:00053818.2SLC5A6, CHRM3, AQP3, TGFB1, PTGS2
5MP:00020068.2ACE, TGFB1, PTGS2, PIK3CA
6MP:00053888.0HBEGF, PTGS2, TGFB1, AQP3, CHRM3, SLC5A6
7MP:00053707.7PTGS2, TGFB1, CHRM3, ACE, SLC5A6
8MP:00053757.6PIK3CA, PTGS2, TGFB1, CHRM3, ACE, UMOD
9MP:00036317.5PIK3CA, HBEGF, PTGS2, TGFB1, CHRM3, SLC5A6
10MP:00053897.5PIK3CA, PTGS2, TGFB1, AQP2, ACE
11MP:00053797.3PIK3CA, PTGS2, TGFB1, CHRM3, ACE, SLC5A6
12MP:00053877.2PIK3CA, PTGS2, TGFB1, AQP3, ACE, UMOD
13MP:00107686.9PIK3CA, HBEGF, PTGS2, TGFB1, AQP3, AQP2
14MP:00053676.8PTGS2, TGFB1, AQP3, AQP2, CHRM3, ACE
15MP:00053856.8PIK3CA, HBEGF, PTGS2, TGFB1, AQP3, CHRM3
16MP:00053866.4PIK3CA, HBEGF, PTGS2, TGFB1, AQP3, AQP2
17MP:00053786.1SLC5A6, PIK3CA, HBEGF, PTGS2, TGFB1, AQP3
18MP:00053766.1PIK3CA, HBEGF, PTGS2, TGFB1, AQP3, AQP2

Publications for Urinary Tract Obstruction

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52PubMed
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Articles related to Urinary Tract Obstruction:

(show top 50)    (show all 307)
idTitleAuthorsYear
1
Erdheim-Chester disease: an uncommon cause of upper urinary tract obstruction. (24088590)
2013
2
Fetal lower urinary tract obstruction and its management. (23138754)
2013
3
Urinary tract obstruction in the mouse: the kinetics of distal nephron injury. (23917879)
2013
4
The Percutaneous shunting in Lower Urinary Tract Obstruction (PLUTO) study and randomised controlled trial: evaluation of the effectiveness, cost-effectiveness and acceptability of percutaneous vesicoamniotic shunting for lower urinary tract obstruction. (24331029)
2013
5
Use of inverted fluoroscope's C-arm during endoscopic treatment of urinary tract obstruction in pregnancy: a practicable solution to cut radiation. (20363496)
2010
6
The effect of alpha-blocker treatment on bladder hypoxia inducible factor-1 alpha regulation during lower urinary tract obstruction. (20202240)
2010
7
In utero management of fetal lower urinary tract obstruction with a novel shunt: a landmark development in fetal therapy. (19968590)
2010
8
Fetal lower urinary tract obstruction. (19559326)
2009
9
Aberrant planar cell polarity induced by urinary tract obstruction. (19794107)
2009
10
Prenatal intervention for lower urinary tract obstruction. (19484159)
2009
11
Diffusion-weighted magnetic resonance imaging of urinary epithelial cancer with upper urinary tract obstruction: preliminary results. (19031182)
2008
12
Role of urinary biomarkers in the diagnosis of congenital upper urinary tract obstruction. (19468460)
2008
13
Vesicoamniotic shunting for fetal lower urinary tract obstruction: an overview. (17449853)
2007
14
An unusual case of urinary tract obstruction due to imperforate hymen in an 11-month-old infant. (19675802)
2007
15
Lower urinary tract obstruction in a Mediterranean spur-thighed tortoise (Testudo graeca) with coxofemoral arthritis. (17028253)
2006
16
The GP's role in lower urinary tract obstruction. (15686258)
2005
17
Magnetic resonance urography in the diagnosis of urinary tract obstruction after renal transplantation. (12133293)
2002
18
Role of urinary transforming growth factor-beta1 concentration in the diagnosis of upper urinary tract obstruction in children. (12352362)
2002
19
In utero therapy for lower urinary tract obstruction. (11746151)
2001
20
Urinary tract obstruction. (11245776)
2001
21
Simultaneous upper and lower urinary tract obstruction associated with severe genital prolapse: diagnosis and evaluation with magnetic resonance imaging. (11374515)
2001
22
Perinatal differential diagnosis of cystic kidney disease and urinary tract obstruction: anatomic pathologic, ultrasonographic and genetic findings. (10725570)
2000
23
Elevated bladder urine concentration of transforming growth factor-beta1 correlates with upper urinary tract obstruction in children. (10458426)
1999
24
MR pyelography and conventional MR imaging in urinary tract obstruction. (10080734)
1999
25
Imaging and urinary tract obstruction: forward (and backward). (9437054)
1998
26
MR urography in the evaluation of urinary tract obstruction. (9437058)
1998
27
The impact of renal impairment on the management of patients with lower urinary tract obstruction. (9133785)
1997
28
Indinavir urinary stones as origin of upper urinary tract obstruction. (9444746)
1997
29
Urinary tract obstruction in children. (7563375)
1995
30
Physiopathology of hypernatremia following relief of urinary tract obstruction. (7871935)
1994
31
Haemorrhagic infarction of a prolapsed orthotopic ureterocele causing upper urinary tract obstruction. (7827823)
1994
32
Percutaneous nephrostomy in malignant urinary tract obstruction. (8241936)
1993
33
Re: Why renography can fail in the diagnosis of upper urinary tract obstruction. (8435728)
1993
34
The diagnosis of upper urinary tract obstruction. (2362903)
1990
35
Treatment of urinary tract obstruction by cancer of the prostate. (2674991)
1989
36
Fetal urinary tract obstruction and trisomy 18 mosaicism. A case report. (3285006)
1988
37
The effect of radiopharmaceutical choice on the assessment of the relative renal function in upper urinary tract obstruction. (2838283)
1988
38
The prenatal diagnosis of lower urinary tract obstruction using B scan ultrasound: a case report. (142096)
1977
39
Letter: Constipation: a cause of urinary tract obstruction and infection. (1246799)
1976
40
Sodium excretion after relief of urinary tract obstruction in children. (4856776)
1974
41
Quantitative analysis of the third segment of the renogram and its application for the detection of urinary tract obstruction and renal arterial constriction. (5058031)
1972
42
Intra-renal effects of urinary tract obstruction. (4655919)
1972
43
Fibromuscular hyperplasia of the posterior urethra: a cause for lower urinary tract obstruction in male children. (5058027)
1972
44
Hypernatremia complicating partial urinary-tract obstruction. (5454766)
1970
45
Plastic reconstruction in the treatment of urinary-tract obstruction caused by aberrant renal arteries. (5352294)
1969
46
Pronounced polyuria and natriuresis following surgical relief of urinary tract obstruction. (5943546)
1966
47
Electrolyte balance following relief of chronic urinary tract obstruction. (13836557)
1959
48
The management of hydronephrosis due to upper urinary tract obstruction. (14804202)
1951
49
Aneurysm of the hypogastric artery producing urinary tract obstruction; report of a case. (20295855)
1947
50
Congenital lower urinary tract obstruction; case report. (20279604)
1946

Variations for Urinary Tract Obstruction

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Expression for genes affiliated with Urinary Tract Obstruction

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Urinary Tract Obstruction

Search GEO for disease gene expression data for Urinary Tract Obstruction.

Pathways for genes affiliated with Urinary Tract Obstruction

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Sources:
50PathCards, 30KEGG, 38NCBI BioSystems Database, 60Thomson Reuters, 55Reactome, 51PharmGKB, 53QIAGEN
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Pathways related to Urinary Tract Obstruction according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8AQP2, AQP3
29.7PIK3CA, HBEGF
39.7HBEGF, PIK3CA
49.6TGFB1, PIK3CA
59.6TGFB1, PIK3CA
6
Show member pathways
Translation Non genomic rapid action of Androgen Receptor60
9.3TGFB1, HBEGF, PIK3CA
79.3TGFB1, HBEGF, PIK3CA
8
Show member pathways
9.2PIK3CA, HBEGF, CHRM3
9
Show member pathways
9.2TGFB1, ACE
109.0PIK3CA, PTGS2, TGFB1
11
Show member pathways
Transcription Receptor mediated HIF regulation60
Development CNTF receptor signaling60
Class IB PI3K non-lipid kinase events38
ErbB2/ErbB3 signaling events38
Development Growth hormone signaling via PI3K AKT and MAPK cascades60
Translation Regulation activity of EIF260
Regulation of lipid metabolism Insulin signaling generic cascades60
Transcription PPAR Pathway60
Cell adhesion PLAU signaling60
Translation Regulation activity of EIF4F60
9.0TGFB1, PTGS2, PIK3CA
129.0TGFB1, PTGS2, PIK3CA
13
Show member pathways
9.0PIK3CA, PTGS2, TGFB1
14
Show member pathways
8.9CHRM3, PTGS2, PIK3CA
15
Show member pathways
Toll-like receptor signaling pathway38
Regulation of toll-like receptor signaling pathway38
8.8ACE, TGFB1, PIK3CA
168.8PIK3CA, HBEGF, TGFB1, SLC5A6
17
Show member pathways
8.6PTGS2, TGFB1, ACE

Compounds for genes affiliated with Urinary Tract Obstruction

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Sources:
45Novoseek, 29IUPHAR, 24HMDB, 11DrugBank, 51PharmGKB, 61Tocris Bioscience
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Compounds related to Urinary Tract Obstruction according to GeneCards/GeneDecks:

(show top 50)    (show all 64)
idCompoundScoreTop Affiliating Genes
1hgcl24510.2AQP3, AQP2
2hg2+2910.2AQP2, AQP3
3hcec4510.1PIK3CA, HBEGF
4mercury4510.1AQP3, AQP2
5staurosporin4510.0PIK3CA, HBEGF
6urea45 24 1111.8UMOD, AQP2, AQP3
7nacl459.8UMOD, AQP2, HBEGF
8alginate459.7TGFB1, HBEGF
9tramadol51 45 1111.7CHRM3, PTGS2
10bromodeoxyuridine459.7TGFB1, HBEGF, PIK3CA
11dmso459.6AQP2, TGFB1, PIK3CA
12benazepril45 51 1111.6ACE, TGFB1
13ramipril45 1110.5TGFB1, ACE
14ag 1478459.5PTGS2, HBEGF, PIK3CA
15matrigel459.5TGFB1, HBEGF, PIK3CA
16perindopril45 51 1111.5TGFB1, ACE
17desmopressin45 61 29 1112.5AQP2, PTGS2
18hydrochlorothiazide45 29 51 24 1113.4ACE, AQP2
19polysaccharide459.4HBEGF, TGFB1, UMOD
20amiodarone45 51 29 1112.4TGFB1, ACE
21pdtc459.4PIK3CA, PTGS2, TGFB1
22inositol459.4PIK3CA, CHRM3, SLC5A6
23candesartan45 51 29 1112.4TGFB1, ACE
24bumetanide45 61 29 51 1113.3ACE, PTGS2
25ang ii459.3HBEGF, TGFB1, ACE
26heparin45 29 24 1112.3PIK3CA, HBEGF, CHRM3, UMOD
27adenylate459.2PIK3CA, AQP3, AQP2, CHRM3
28metformin45 51 1111.2ACE, TGFB1, PIK3CA
29etoposide45 51 61 1112.2PIK3CA, PTGS2, TGFB1
30chloride459.2SLC5A6, CHRM3, AQP2, AQP3
31sb 20358045 6110.2TGFB1, PTGS2, HBEGF
32cyclosporin a45 29 6111.1PIK3CA, TGFB1, AQP2, CHRM3
33sildenafil29 45 51 24 1113.1ACE, TGFB1
34pge2459.1AQP2, TGFB1, PTGS2, HBEGF
35pd 98,059459.1PIK3CA, HBEGF, PTGS2, TGFB1
36ly294002459.1TGFB1, PTGS2, HBEGF, PIK3CA
37actinomycin d459.1PIK3CA, HBEGF, PTGS2, TGFB1
38vegf458.9PIK3CA, HBEGF, PTGS2, TGFB1
39aspirin45 51 29 2411.9ACE, TGFB1, PTGS2
40threonine458.8PIK3CA, TGFB1, AQP3, AQP2, CHRM3
41cisplatin45 51 61 1111.7PIK3CA, HBEGF, PTGS2, TGFB1, AQP2
42creatinine458.6TGFB1, AQP3, AQP2, ACE, UMOD
43potassium45 24 1110.4PIK3CA, AQP2, ACE, UMOD, SLC5A6
44sodium45 249.4SLC5A6, UMOD, ACE, AQP2, PIK3CA
45dexamethasone45 51 29 1111.4PIK3CA, HBEGF, PTGS2, TGFB1, AQP3, AQP2
46nitric oxide45 24 1110.4PIK3CA, HBEGF, PTGS2, AQP2, ACE
47norepinephrine45 24 1110.3CHRM3, ACE, SLC5A6
48lipid457.9PIK3CA, HBEGF, AQP2, CHRM3, ACE, SLC5A6
49calcium45 51 24 1110.6PIK3CA, HBEGF, AQP2, CHRM3, ACE, UMOD
50glucose457.3SLC5A6, PIK3CA, HBEGF, AQP3, AQP2, CHRM3

GO Terms for genes affiliated with Urinary Tract Obstruction

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16Gene Ontology
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Cellular components related to Urinary Tract Obstruction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1basolateral plasma membraneGO:0163238.8UMOD, CHRM3, AQP2, AQP3
2extracellular spaceGO:0056158.5UMOD, ACE, TGFB1, HBEGF
3plasma membraneGO:0058866.8PIK3CA, TGFB1, AQP3, AQP2, CHRM3, ACE

Biological processes related to Urinary Tract Obstruction according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1water transportGO:00683310.0AQP2, AQP3
2protein kinase B signalingGO:0434919.8PIK3CA, TGFB1
3response to lithium ionGO:0102269.7PTGS2, AQP2
4excretionGO:0075889.7UMOD, AQP2, AQP3
5response to calcium ionGO:0515929.7AQP2, AQP3
6positive regulation vascular endothelial growth factor productionGO:0105759.6TGFB1, PTGS2
7positive regulation of peptidyl-serine phosphorylationGO:0331389.6PIK3CA, TGFB1
8positive regulation of smooth muscle cell proliferationGO:0486619.6PTGS2, HBEGF
9positive regulation of smooth muscle contractionGO:0459879.6CHRM3, PTGS2
10negative regulation of cell cycleGO:0457869.5TGFB1, PTGS2
11epidermal growth factor receptor signaling pathwayGO:0071739.5TGFB1, HBEGF, PIK3CA
12mononuclear cell proliferationGO:0329439.5ACE, TGFB1
13response to vitamin DGO:0332809.4AQP3, TGFB1, PTGS2
14regulation of blood pressureGO:0082179.0ACE, PTGS2
15negative regulation of cell proliferationGO:0082858.8UMOD, TGFB1, PTGS2

Molecular functions related to Urinary Tract Obstruction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1drug bindingGO:0081449.1ACE, CHRM3

Products for genes affiliated with Urinary Tract Obstruction

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  • Antibodies
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Sources for Urinary Tract Obstruction

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet