MCID: URN010
MIFTS: 52

Urinary Tract Obstruction malady

Nephrological category

Summaries for Urinary Tract Obstruction

Sources:
64Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:64 Urinary tract obstruction is a urologic disease consisting of a decrease in the free passage of urine... more...

MalaCards: Urinary Tract Obstruction, also known as obstructive uropathy, is related to ureteral obstruction and diabetes insipidus. An important gene associated with Urinary Tract Obstruction is HBEGF (heparin-binding EGF-like growth factor), and among its related pathways are Passive Transport by Aquaporins and Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics. The compounds estrogen and hgcl2 have been mentioned in the context of this disorder. Affiliated tissues include kidney, lung and smooth muscle, and related mouse phenotypes are adipose tissue and respiratory system.

Aliases & Classifications for Urinary Tract Obstruction

Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 45Novoseek, 57SNOMED-CT, 27ICD9CM, 40NCIt, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological


Aliases & Descriptions:

urinary tract obstruction 8 10 61
obstructive uropathy 8 45
obstructive uropathy, unspecified 8
urinary obstruction, unspecified 8
urinary obstruction unspecified 8
obstructive uropathy nos 8
urinary obstruction 8


External Ids:

Disease Ontology8 DOID:5200
ICD9CM27 599.6, 599.60
ICD1025 N13.9, N20.9

Related Diseases for Urinary Tract Obstruction

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Urinary Tract Obstruction via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 154)
idRelated DiseaseScoreTop Affiliating Genes
1ureteral obstruction30.5TGFB1
2diabetes insipidus30.4AQP2
3vesicoureteral reflux30.1UMOD
4nephrolithiasis30.1UMOD, CHRM3
5arthritis30.1TGFB1, PTGS2, B2M
6adenocarcinoma30.1PTGS2, PIK3CA, KLK3, HBEGF, AQP3, TGFB1
7wilms tumor30.1HBEGF
8anuria30.1ACE
9nephritis30.1B2M, FBXL20, ACE
10vascular disease29.9PTGS2
11urethral obstruction10.5
12retroperitoneal fibrosis10.4
13hydronephrosis10.4
14posterior valve urethra10.4
15posterior urethral valve10.4
16nephrogenic diabetes insipidus10.3
17kashani strom utley syndrome10.3
18glandular cystitis10.3
19prune belly syndrome10.3
20posterior urethral valves10.3
21ovarian hyperstimulation syndrome10.2
22split hand urinary anomalies spina bifida10.2
23transient pseudohypoaldosteronism10.2
24bacteriuria10.1
25dyskeratosis congenita10.1
26erdheim-chester disease10.1
27sarcomatoid renal cell carcinoma10.1
28pseudohypoaldosteronism10.1
29urethral syndrome10.1
30syndactyly10.1
31gastroschisis10.1
32acute pyelonephritis10.1
33urethral diverticulum10.1
34ureterocele10.1
35renal tuberculosis10.1
36renal tubular acidosis10.1
37n syndrome10.1
38amyloidosis10.1
39tuberculosis10.1
40urethral stricture10.1
41penoscrotal transposition10.1
42neural tube defects10.1
43renal tubular acidosis, distal10.1
44hypoxia10.1
45teratoma10.1
46split foot10.1
47split hand10.1
48renal dysplasia10.1
49nodular prostate10.1
50pelvic lipomatosis10.1

Graphical network of the top 20 diseases related to Urinary Tract Obstruction:



Diseases related to urinary tract obstruction

Clinical Features for Urinary Tract Obstruction

Drugs & Therapeutics for Urinary Tract Obstruction

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Urinary Tract Obstruction

Drug clinical trials:

Search ClinicalTrials for Urinary Tract Obstruction

Search NIH Clinical Center for Urinary Tract Obstruction

Search CenterWatch for Urinary Tract Obstruction

Genetic Tests for Urinary Tract Obstruction

Anatomical Context for Urinary Tract Obstruction

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Urinary Tract Obstruction:

33
Kidney, Lung, Smooth muscle, Prostate, Cervix, Monocytes, B cells, Fetal lung

Animal Models for Urinary Tract Obstruction or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Urinary Tract Obstruction

Sources:
51PubMed
See all sources

Articles related to Urinary Tract Obstruction:

(show top 50)    (show all 328)
idTitleAuthorsYear
1
Fetal lower urinary tract obstruction and its management. (23138754)
2013
2
Urinary tract obstruction in the mouse: the kinetics of distal nephron injury. (23917879)
2013
3
Monosodium glutamate (MSG) consumption is associated with urolithiasis and urinary tract obstruction in rats. (24086562)
2013
4
Urinary tract infection associated with conditions causing urinary tract obstruction and stasis, excluding urolithiasis and neuropathic bladder. (21720861)
2012
5
Urinary tract obstruction: ureteral stents--weighing up the risks and benefits. (22158593)
2012
6
Congenital urinary tract obstruction: defining markers of developmental kidney injury. (22902433)
2012
7
Urinary tract obstruction: stents in pyeloplasty: beware of false precision. (21562481)
2011
8
Quantitative analysis of renal vascularization in fetuses with urinary tract obstruction by three-dimensional power-Doppler. (21861967)
2011
9
Systematic review of the effectiveness of antenatal intervention for the treatment of congenital lower urinary tract obstruction. (20374578)
2010
10
Urinary tract obstruction induces transient accumulation of COX-2-derived prostanoids in kidney tissue. (20147610)
2010
11
Plumbing the depths of urinary tract obstruction by using murine models. (19568351)
2009
12
Acute pyelonephritis associated with transudative pleural effusion in a middle-aged woman without urinary tract obstruction. (16763401)
2006
13
Dynamic MR urography in urinary tract obstruction: implementation and preliminary results. (16465573)
2006
14
Pulmonary endocrine cells in hypoplastic lungs due to foetal urinary tract obstruction: a microscopic immunohistochemical study. (16428096)
2006
15
Correlation between ultrasound and anatomical findings in fetuses with lower urinary tract obstruction in the first half of pregnancy. (15816021)
2005
16
Factors influencing the non-recovery of renal function after the relief of urinary tract obstruction in women with cancer of cervix. (12739828)
2003
17
Simultaneous upper and lower urinary tract obstruction associated with severe genital prolapse: diagnosis and evaluation with magnetic resonance imaging. (11374515)
2001
18
Perinatal differential diagnosis of cystic kidney disease and urinary tract obstruction: anatomic pathologic, ultrasonographic and genetic findings. (10725570)
2000
19
Combined static-dynamic MR urography for the simultaneous evaluation of morphology and function in urinary tract obstruction. I. Evaluation of the normal status in an animal model. (10993535)
2000
20
MR urography in the diagnosis of urinary tract obstruction. (9933803)
1999
21
Imaging and urinary tract obstruction: forward (and backward). (9437054)
1998
22
Advances in radionuclide evaluation of urinary tract obstruction. (9437057)
1998
23
A prospective randomized trial comparing 2 diuresis renography techniques for evaluation of suspected upper urinary tract obstruction in children. (9554395)
1998
24
Indinavir urinary stones as origin of upper urinary tract obstruction. (9444746)
1997
25
Acute urinary tract obstruction. Imaging update. (9275979)
1997
26
Urinary tract obstruction during pregnancy: recent developments in imaging. (9240216)
1997
27
Spontaneous resolution of upper urinary tract obstruction in an anuric premature neonate. (8865264)
1996
28
Physiopathology of hypernatremia following relief of urinary tract obstruction. (7871935)
1994
29
Split hand/split foot, syndactyly, urinary tract obstruction, radial, diaphragmatic, and neural tube defects: Czeizel-Losonci syndrome? (8074153)
1994
30
Non-dilated urinary tract obstruction. (1620019)
1992
31
Image guided localized 31P magnetic resonance spectroscopy of acute urinary tract obstruction. (1997726)
1991
32
Acute renal failure due to urinary tract obstruction. (2195262)
1990
33
Fetal urinary tract obstruction and trisomy 18 mosaicism. A case report. (3285006)
1988
34
A comparison of technetium-99m-thiodiglycolic acid and iodine-123-hippuran in the evaluation of equivocal upper urinary tract obstruction. (3620825)
1987
35
Fetal urinary tract obstruction: is active intervention before delivery indicated? (6838791)
1983
36
Radionuclide measurement of differential glomerular filtration rate in urinary tract obstruction. (6290414)
1982
37
Use of the radionuclide washout test in evaluation of suspected upper urinary tract obstruction. (7206088)
1981
38
Pleural effusion associated with urinary tract obstruction: support for a hypothesis. (7314037)
1981
39
Severe hypernatremia complicating urinary tract obstruction. (6189276)
1980
40
Urinary tract obstruction in polycystic renal disease. (928684)
1977
41
Upper urinary tract obstruction: pressure/flow studies in children. (1009324)
1976
42
Ascites and lower urinary tract obstruction in the newborn. (4696924)
1973
43
Intra-renal effects of urinary tract obstruction. (4655919)
1972
44
Drip infusion pyelography with delayed drainage films in urinary tract obstruction. (4502571)
1972
45
Urinary tract obstruction in causation of infection, stone formation and renal failure. (4643956)
1972
46
Hypernatremia complicating partial urinary-tract obstruction. (5454766)
1970
47
Pronounced polyuria and natriuresis following surgical relief of urinary tract obstruction. (5943546)
1966
48
Changing concepts in lower urinary-tract obstruction in children. (13711036)
1961
49
Urinary tract obstruction: what has been learned about it, and what is still to be learned. (13564595)
1958
50
Aneurysm of the hypogastric artery producing urinary tract obstruction; report of a case. (20295855)
1947

Genetic Variations for Urinary Tract Obstruction

Expression for genes affiliated with Urinary Tract Obstruction

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Urinary Tract Obstruction

Search GEO for disease gene expression data for Urinary Tract Obstruction.

Pathways for genes affiliated with Urinary Tract Obstruction

Sources:
54Reactome, 50PharmGKB, 38NCBI BioSystems Database, 12EMD Millipore, 30KEGG
See all sources

Pathways related to Urinary Tract Obstruction according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9AQP2, AQP3
2
Hide members
9.8TGFB1, ACE
3
Transcription Androgen Receptor nuclear signaling
Hide members
9.1PIK3CA, KLK3, HBEGF, TGFB1
48.9TGFB1, KLK3, PIK3CA, PTGS2

Compounds for genes affiliated with Urinary Tract Obstruction

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 50PharmGKB, 60Tocris Bioscience, 24HMDB, 2BitterDB
See all sources

Compounds related to Urinary Tract Obstruction according to GeneCards/GeneDecks:

(show top 50)    (show all 62)
idCompoundScoreTop Affiliating Genes
1estrogen4510.5KLK3
2hgcl24510.3AQP2, AQP3
3hg2+2910.3AQP2, AQP3
4mannitol45 1111.2AQP3, HBEGF
5benazepril45 1111.1ACE, TGFB1
6an 694510.1ACE, B2M
7ang ii459.9ACE, TGFB1, HBEGF
8isradipine45 29 1111.9B2M, ACE
9tramadol45 50 1111.9CHRM3, PTGS2
10candesartan45 29 1111.9KLK3, ACE, TGFB1
11pge2459.8TGFB1, AQP2, PTGS2
12exisulind459.8PTGS2, KLK3
13desmopressin45 60 29 1112.7AQP2, PTGS2, B2M
14urea45 11 2411.7AQP2, AQP3, B2M, UMOD
15metformin45 50 1111.7TGFB1, ACE, PIK3CA
16ramipril45 1110.7ACE, TGFB1
176-ketoprostaglandin f1alpha459.6B2M, PTGS2
18ag 1478459.6PIK3CA, HBEGF, PTGS2
19potassium45 11 2411.6AQP2, SLC5A6, ACE
20thalidomide45 50 60 1112.6PTGS2, B2M, KLK3
21pdtc459.6PIK3CA, PTGS2, TGFB1
22docetaxel45 50 60 1112.5PIK3CA, TGFB1, KLK3
23gefitinib45 50 1111.5PIK3CA, KLK3, PTGS2
24nifedipine45 50 29 1112.5B2M, TGFB1, ACE
25bromodeoxyuridine459.5HBEGF, PIK3CA, TGFB1
26paraffin459.5KLK3, TGFB1, HBEGF, B2M
27creatinine459.4AQP3, UMOD, TGFB1, ACE, AQP2
28polysaccharide459.4TGFB1, KLK3, B2M, UMOD, HBEGF
29sodium45 2410.4SLC5A6, AQP2, ACE, UMOD
30doxorubicin45 50 1111.3KLK3, TGFB1, B2M, PIK3CA
31aspirin45 50 29 2412.3PTGS2, ACE, KLK3, TGFB1
32biotin45 11 2411.3AQP2, B2M, SLC5A6, KLK3
33pd 98,059459.3HBEGF, PIK3CA, PTGS2, TGFB1
34ly294002459.3TGFB1, PTGS2, HBEGF, PIK3CA
35actinomycin d459.3TGFB1, PTGS2, PIK3CA, HBEGF
36etoposide45 50 60 1112.2KLK3, PIK3CA, TGFB1, PTGS2
37cyclosporin a45 29 6011.2AQP2, B2M, PIK3CA, TGFB1, CHRM3
38threonine459.1AQP2, AQP3, CHRM3, TGFB1, PIK3CA
39cycloheximide459.1TGFB1, PTGS2, HBEGF, B2M, KLK3
40genistein45 29 60 2 11 2414.1PIK3CA, B2M, HBEGF, PTGS2
41inositol459.1CHRM3, SLC5A6, PIK3CA
42chloride459.1AQP2, AQP3, SLC5A6, CHRM3, B2M
43nitric oxide45 11 2410.9AQP2, PTGS2, ACE, PIK3CA, HBEGF
44cisplatin45 50 60 1111.8PIK3CA, TGFB1, AQP2, PTGS2, HBEGF, B2M
45lactate458.7TGFB1, B2M, PIK3CA, KLK3
46vegf458.7KLK3, TGFB1, PTGS2, HBEGF, B2M, PIK3CA
47dexamethasone45 50 29 1111.5KLK3, PIK3CA, HBEGF, PTGS2, AQP3, AQP2
48lipid458.5ACE, SLC5A6, CHRM3, PIK3CA, AQP2, HBEGF
49calcium45 50 11 2410.9AQP2, ACE, CHRM3, SLC5A6, HBEGF, B2M
50glucose457.7CHRM3, UMOD, PIK3CA, B2M, HBEGF, SLC5A6

GO Terms for genes affiliated with Urinary Tract Obstruction

Sources:
16Gene Ontology
See all sources

Cellular components related to Urinary Tract Obstruction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1basolateral plasma membraneGO:0163239.1AQP2, AQP3, CHRM3, UMOD
2extracellular spaceGO:0056158.9TGFB1, ACE, HBEGF, B2M, UMOD

Biological processes related to Urinary Tract Obstruction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mononuclear cell proliferationGO:0329439.8TGFB1, ACE
2excretionGO:0075889.7AQP2, UMOD, AQP3
3positive regulation vascular endothelial growth factor productionGO:0105759.7PTGS2, TGFB1
4response to lithium ionGO:0102269.6PTGS2, AQP2
5response to vitamin DGO:0332809.5PTGS2, AQP3, TGFB1
6positive regulation of smooth muscle contractionGO:0459879.3PTGS2, CHRM3

Products for genes affiliated with Urinary Tract Obstruction

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Urinary Tract Obstruction

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet