MCID: URN010
MIFTS: 55

Urinary Tract Obstruction malady

Nephrological diseases category

Summaries for Urinary Tract Obstruction

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63Wikipedia, 32MalaCards
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Wikipedia:63 Urinary tract obstruction is a urologic disease consisting of a decrease in the free passage of urine... more...

MalaCards: Urinary Tract Obstruction, also known as obstructive uropathy, is related to ureteral obstruction and prostatitis. An important gene associated with Urinary Tract Obstruction is HBEGF (heparin-binding EGF-like growth factor), and among its related pathways are Passive Transport by Aquaporins and Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics. The compounds estrogen and hgcl2 have been mentioned in the context of this disorder. Affiliated tissues include kidney, prostate and testes, and related mouse phenotypes are adipose tissue and respiratory system.

Aliases & Classifications for Urinary Tract Obstruction

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 27ICD9CM, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological diseases


Aliases & Descriptions:

urinary tract obstruction 8 10 60
obstructive uropathy 8 44
obstructive uropathy, unspecified 8
urinary obstruction, unspecified 8
urinary obstruction unspecified 8
obstructive uropathy nos 8
urinary obstruction 8


External Ids:

Disease Ontology8 DOID:5200
ICD9CM27 599.6, 599.60
ICD1025 N13.9, N20.9

Related Diseases for Urinary Tract Obstruction

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17GeneCards, 18GeneDecks
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Diseases related to Urinary Tract Obstruction via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 148)
idRelated DiseaseScoreTop Affiliating Genes
1ureteral obstruction30.6TGFB1
2prostatitis30.6KLK3
3diabetes insipidus30.4AQP2
4vesicoureteral reflux30.3UMOD
5leiomyoma30.1HBEGF
6pyelonephritis30.1B2M, UMOD
7nephrolithiasis30.1CHRM3, UMOD
8hypertension30.1FBXL20, ACE, TGFB1
9ovarian cancer30.1PIK3CA, HBEGF, TGFB1
10arthritis30.1TGFB1, PTGS2, B2M
11prostate cancer30.1KLK3, PIK3CA, HBEGF, PTGS2, TGFB1
12adenocarcinoma30.1KLK3, PIK3CA, HBEGF, PTGS2, AQP3, TGFB1
13oligohydramnios30.1ACE
14sarcoidosis30.1ACE
15anuria30.1ACE
16vascular disease29.8PTGS2
17chronic pyelonephritis29.8B2M, UMOD
18urethritis10.5
19urethral obstruction10.5
20hydronephrosis10.3
21nephrogenic diabetes insipidus10.3
22kashani strom utley syndrome10.3
23renal artery obstruction10.2
24cystitis10.2
25ovarian hyperstimulation syndrome10.2
26phimosis10.2
27split hand urinary anomalies spina bifida10.2
28retroperitoneal fibrosis10.2
29bacteriuria10.1
30dyskeratosis congenita10.1
31erdheim-chester disease10.1
32sarcomatoid renal cell carcinoma10.1
33pseudohypoaldosteronism10.1
34urethral syndrome10.1
35syndactyly10.1
36gastroschisis10.1
37acute pyelonephritis10.1
38urethral diverticulum10.1
39ureterocele10.1
40renal tuberculosis10.1
41renal tubular acidosis10.1
42amyloidosis10.1
43constipation10.1
44cystic kidney10.1
45endometriosis10.1
46histoplasmosis10.1
47kidney disease10.1
48neurofibroma10.1
49renal cell carcinoma10.1
50tuberculosis10.1

Graphical network of the top 20 diseases related to Urinary Tract Obstruction:



Diseases related to urinary tract obstruction

Clinical Features for Urinary Tract Obstruction

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Drugs & Therapeutics for Urinary Tract Obstruction

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Urinary Tract Obstruction

Drug clinical trials:

Search ClinicalTrials for Urinary Tract Obstruction

Search NIH Clinical Center for Urinary Tract Obstruction

Search CenterWatch for Urinary Tract Obstruction

Genetic Tests for Urinary Tract Obstruction

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Anatomical Context for Urinary Tract Obstruction

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32MalaCards
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MalaCards organs/tissues related to Urinary Tract Obstruction:

32
Kidney, Prostate, Testes, Lung, Smooth muscle, Cervix, Monocytes, B cells, Fetal lung

Animal Models for Urinary Tract Obstruction or affiliated genes

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36MGI
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Publications for Urinary Tract Obstruction

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Sources:
50PubMed
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Articles related to Urinary Tract Obstruction:

(show top 50)    (show all 338)
idTitleAuthorsYear
1
Erdheim-Chester disease: an uncommon cause of upper urinary tract obstruction. (24088590)
2013
2
Laparoscopic ureterocalicostomy for complicated upper urinary tract obstruction: mid-term follow-up. (24217801)
2013
3
Prenatal cytogenetic diagnosis from fetal urine in lower urinary tract obstruction. (23751043)
2013
4
Outcome of prenatally detected bilateral higher urinary tract obstruction or megacystis: sex-related study on a series of 709 cases. (22544566)
2012
5
Re: Use of Inverted Fluoroscope's C-Arm During Endoscopic Treatment of Urinary Tract Obstruction in Pregnancy: A Practicable Solution to Cut Radiation. (22082925)
2011
6
Candida bezoars with urinary tract obstruction in two women without immunocompromising conditions. (21666985)
2011
7
Glomerular sclerosis is prevented during urinary tract obstruction due to podocyte protection. (21177778)
2011
8
An unusual aetiology of lower urinary tract obstruction. (21365315)
2011
9
Urinary tract obstruction: Renal function reserve predicts long-term renal deterioration in children with posterior urethral valve. (21647185)
2011
10
Use of inverted fluoroscope's C-arm during endoscopic treatment of urinary tract obstruction in pregnancy: a practicable solution to cut radiation. (20363496)
2010
11
The effect of alpha-blocker treatment on bladder hypoxia inducible factor-1 alpha regulation during lower urinary tract obstruction. (20202240)
2010
12
Fetal cardiovascular effects of lower urinary tract obstruction with giant bladder. (20503245)
2010
13
Prenatal intervention for lower urinary tract obstruction. (19484159)
2009
14
Lower urinary tract obstruction secondary to congenital bladder diverticula in infants. (19727770)
2009
15
Occurrence of urinary tract infection in children with significant upper urinary tract obstruction. (18619654)
2009
16
Four-dimensional ultrasonographic imaging of fetal lower urinary tract obstruction and guidance of percutaneous cystoscopy. (19173237)
2009
17
Antenatal ultrasound to predict postnatal renal function in congenital lower urinary tract obstruction: systematic review of test accuracy. (19438489)
2009
18
Requirements for accurately diagnosing chronic partial upper urinary tract obstruction in children with hydronephrosis. (18074126)
2008
19
PLUTO trial protocol: percutaneous shunting for lower urinary tract obstruction randomised controlled trial. (17567421)
2007
20
Feasibility of percutaneous nephrolithotomy under assisted local anaesthesia: a prospective study on selected patients with upper urinary tract obstruction. (16842905)
2007
21
Discordant lower urinary tract obstruction in early twin gestations: management and outcome. (16199638)
2005
22
The association of obstructive defecation, lower urinary tract dysfunction and the benign joint hypermobility syndrome: a case-control study. (12851757)
2003
23
Possible maternal inheritance of a common obstructive urinary tract anomaly. Report of a case of a woman with multiple urinary tract infections and two sons with posterior urethral valves. (12497693)
2002
24
Data from frequency-volume charts versus maximum free flow rate, residual volume, and voiding cystometric estimated urethral obstruction grade and detrusor contractility grade in men with lower urinary tract symptoms suggestive of benign prostatic hyperplasia. (12232879)
2002
25
Urinary tract obstruction. (11245776)
2001
26
Functional urinary tract obstruction developing in fetuses with isolated gastroschisis. (10846773)
2000
27
The diagnosis of upper urinary tract obstruction. (10368226)
1999
28
Radiologic findings in acute urinary tract obstruction. (9258784)
1997
29
Abdominoscrotal hydrocele causing upper urinary tract displacement and obstruction. (8442305)
1993
30
Re: Bladder outflow tract obstruction and urinary retention from benign prostatic hypertrophy treated by balloon dilatation. (1699630)
1990
31
Serum and renal tissue concentrations of cefotaxime in urinary tract obstruction in rabbits. (3396491)
1988
32
Upper urinary tract obstruction in children: current controversies in diagnosis. (3309851)
1987
33
Fetal urinary tract obstruction: management and selection for treatment. (3898388)
1985
34
Renal cortical drug and xenobiotic metabolism following urinary tract obstruction. (6433098)
1984
35
Uterine prolapse and urinary tract obstruction. (6430426)
1984
36
External bladder--amniotic fluid shunt for fetal urinary tract obstruction. (6538325)
1984
37
Correction of congenital hydronephrosis in utero II. Decompression reverses the effects of obstruction on the fetal lung and urinary tract. (7161685)
1982
38
Acute urinary tract obstruction in dyskeratosis congenita. (7240462)
1981
39
Diuresis renography in equivocal urinary tract obstruction. (754856)
1978
40
Letter: Constipation: a cause of urinary tract obstruction and infection. (1246799)
1976
41
Assessment of urinary tract obstruction using a perfusion technique. (1005670)
1976
42
Editorial: Lower urinary tract obstruction. (4772824)
1973
43
Fibromuscular hyperplasia of the posterior urethra: a cause for lower urinary tract obstruction in male children. (5058027)
1972
44
Perineal neurofibroma. An unusual cause of urinary tract obstruction. (5428533)
1970
45
Plastic reconstruction in the treatment of urinary-tract obstruction caused by aberrant renal arteries. (5352294)
1969
46
The case for loop ureterostomy in the infant with advanced lower urinary tract obstruction. (5776033)
1969
47
PROSTATIC ENLARGEMENT AND LOWER URINARY TRACT OBSTRUCTION. (14141801)
1964
48
MASSIVE POLYURIA AND NATRURESIS FOLLOWING RELIEF OF URINARY TRACT OBSTRUCTION. (14206763)
1964
49
EXPERIMENTAL BLADDER NECK OBSTRUCTION. I. INCIDENCE OF VESICOURETERAL REFLUX, UPPER TRACT DILATION, AND URINARY INFECTION IN RABBITS. (14078534)
1963
50
Lower urinary tract obstruction in children; a pediatric review. (13224167)
1955

Genetic Variations for Urinary Tract Obstruction

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Expression for genes affiliated with Urinary Tract Obstruction

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Urinary Tract Obstruction

Search GEO for disease gene expression data for Urinary Tract Obstruction.

Pathways for genes affiliated with Urinary Tract Obstruction

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Sources:
53Reactome, 49PharmGKB, 37NCBI BioSystems Database, 12EMD Millipore, 29KEGG
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Pathways related to Urinary Tract Obstruction according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9AQP2, AQP3
2
Hide members
9.8TGFB1, ACE
3
Transcription Androgen Receptor nuclear signaling
Hide members
9.1TGFB1, HBEGF, PIK3CA, KLK3
48.9KLK3, PIK3CA, PTGS2, TGFB1

Compounds for genes affiliated with Urinary Tract Obstruction

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 49PharmGKB, 59Tocris Bioscience, 24HMDB, 2BitterDB
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Compounds related to Urinary Tract Obstruction according to GeneCards/GeneDecks:

(show top 50)    (show all 62)
idCompoundScoreTop Affiliating Genes
1estrogen4410.5KLK3
2hgcl24410.3AQP2, AQP3
3hg2+2810.3AQP2, AQP3
4mannitol44 1111.2AQP3, HBEGF
5benazepril44 1111.1ACE, TGFB1
6an 694410.1ACE, B2M
7ang ii449.9ACE, TGFB1, HBEGF
8isradipine44 28 1111.9B2M, ACE
9tramadol44 49 1111.9CHRM3, PTGS2
10candesartan44 28 1111.9KLK3, ACE, TGFB1
11pge2449.8TGFB1, AQP2, PTGS2
12exisulind449.8PTGS2, KLK3
13desmopressin44 59 28 1112.7AQP2, PTGS2, B2M
14urea44 11 2411.7AQP2, AQP3, B2M, UMOD
15metformin44 49 1111.7TGFB1, ACE, PIK3CA
16ramipril44 1110.7ACE, TGFB1
176-ketoprostaglandin f1alpha449.6B2M, PTGS2
18ag 1478449.6PIK3CA, HBEGF, PTGS2
19potassium44 11 2411.6AQP2, SLC5A6, ACE
20thalidomide44 49 59 1112.6PTGS2, B2M, KLK3
21pdtc449.6PIK3CA, PTGS2, TGFB1
22docetaxel44 49 59 1112.5PIK3CA, TGFB1, KLK3
23gefitinib44 49 1111.5PIK3CA, KLK3, PTGS2
24nifedipine44 49 28 1112.5B2M, TGFB1, ACE
25bromodeoxyuridine449.5HBEGF, PIK3CA, TGFB1
26paraffin449.5KLK3, TGFB1, HBEGF, B2M
27creatinine449.4AQP3, UMOD, TGFB1, ACE, AQP2
28polysaccharide449.4TGFB1, KLK3, B2M, UMOD, HBEGF
29sodium44 2410.4SLC5A6, AQP2, ACE, UMOD
30doxorubicin44 49 1111.3KLK3, TGFB1, B2M, PIK3CA
31aspirin44 49 28 2412.3PTGS2, ACE, KLK3, TGFB1
32biotin44 11 2411.3AQP2, B2M, SLC5A6, KLK3
33pd 98,059449.3HBEGF, PIK3CA, PTGS2, TGFB1
34ly294002449.3TGFB1, PTGS2, HBEGF, PIK3CA
35actinomycin d449.3TGFB1, PTGS2, PIK3CA, HBEGF
36etoposide44 49 59 1112.2KLK3, PIK3CA, TGFB1, PTGS2
37cyclosporin a44 28 5911.2AQP2, B2M, PIK3CA, TGFB1, CHRM3
38threonine449.1AQP2, AQP3, CHRM3, TGFB1, PIK3CA
39cycloheximide449.1TGFB1, PTGS2, HBEGF, B2M, KLK3
40genistein44 28 59 2 11 2414.1PIK3CA, B2M, HBEGF, PTGS2
41inositol449.1CHRM3, SLC5A6, PIK3CA
42chloride449.1AQP2, AQP3, SLC5A6, CHRM3, B2M
43nitric oxide44 11 2410.9AQP2, PTGS2, ACE, PIK3CA, HBEGF
44cisplatin44 49 59 1111.8PIK3CA, TGFB1, AQP2, PTGS2, HBEGF, B2M
45lactate448.7TGFB1, B2M, PIK3CA, KLK3
46vegf448.7KLK3, TGFB1, PTGS2, HBEGF, B2M, PIK3CA
47dexamethasone44 49 28 1111.5KLK3, PIK3CA, HBEGF, PTGS2, AQP3, AQP2
48lipid448.5ACE, SLC5A6, CHRM3, PIK3CA, AQP2, HBEGF
49calcium44 49 11 2410.9AQP2, ACE, CHRM3, SLC5A6, HBEGF, B2M
50glucose447.7CHRM3, UMOD, PIK3CA, B2M, HBEGF, SLC5A6

GO Terms for genes affiliated with Urinary Tract Obstruction

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16Gene Ontology
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Cellular components related to Urinary Tract Obstruction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1basolateral plasma membraneGO:0163239.1AQP2, AQP3, CHRM3, UMOD
2extracellular spaceGO:0056158.9TGFB1, ACE, HBEGF, B2M, UMOD

Biological processes related to Urinary Tract Obstruction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mononuclear cell proliferationGO:0329439.8TGFB1, ACE
2excretionGO:0075889.7UMOD, AQP3, AQP2
3positive regulation vascular endothelial growth factor productionGO:0105759.7TGFB1, PTGS2
4response to lithium ionGO:0102269.6AQP2, PTGS2
5response to vitamin DGO:0332809.5TGFB1, AQP3, PTGS2
6positive regulation of smooth muscle contractionGO:0459879.3PTGS2, CHRM3

Products for genes affiliated with Urinary Tract Obstruction

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  • Antibodies
  • Proteins
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Sources for Urinary Tract Obstruction

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet