MCID: URN010
MIFTS: 57

Urinary Tract Obstruction

Categories: Nephrological diseases

Aliases & Classifications for Urinary Tract Obstruction

MalaCards integrated aliases for Urinary Tract Obstruction:

Name: Urinary Tract Obstruction 12 14 69
Obstructive Uropathy 12 51
Urinary Obstruction 12
Urologic Diseases 69

Classifications:



External Ids:

Disease Ontology 12 DOID:5200
ICD10 32 N13.9
ICD9CM 34 599.6 599.60
NCIt 46 C3675 C79805

Summaries for Urinary Tract Obstruction

MalaCards based summary : Urinary Tract Obstruction, also known as obstructive uropathy, is related to cystitis and vesicoureteral reflux 1, and has symptoms including urologic problem, other and unspecified genitourinary symptoms and renal pain. An important gene associated with Urinary Tract Obstruction is TGFB1 (Transforming Growth Factor Beta 1), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Endometrial cancer. The drugs Tamsulosin and Adrenergic Agents have been mentioned in the context of this disorder. Affiliated tissues include prostate, kidney and bone, and related phenotypes are growth/size/body region and homeostasis/metabolism

Wikipedia : 72 Urinary tract obstruction is a urologic disease consisting of a decrease in the free passage of urine... more...

Related Diseases for Urinary Tract Obstruction

Diseases related to Urinary Tract Obstruction via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 124)
# Related Disease Score Top Affiliating Genes
1 cystitis 30.4 EGF HBEGF PTGS2 UMOD
2 vesicoureteral reflux 1 30.0 NAGLU REN UMOD
3 pyelonephritis 29.9 ALB CCL2 NAGLU UMOD
4 hydronephrosis 29.2 ALB AQP2 B2M CCL2 EGF NAGLU
5 kidney disease 28.4 ALB B2M NAGLU PKDREJ REN UMOD
6 pelvic lipomatosis 11.2
7 adult hepatocellular carcinoma 10.5 EGF PIK3CA
8 lipoid nephrosis 10.4 ALB CCL2 NAGLU
9 tuberculous meningitis 10.4 CCL2 GGT1 TGFB1
10 interstitial cystitis 10.4 EGF HBEGF UMOD
11 acute kidney tubular necrosis 10.4 ALB NAGLU UMOD
12 immunodeficiency 43 10.4 ALB B2M
13 leukoregulin 10.4 PTGS2 TGFB1
14 acute cystitis 10.4 ALB CCL2 KLK3
15 end stage renal failure 10.4 ALB TGFB1 UMOD
16 benign essential hypertension 10.3 ALB REN
17 fanconi-like syndrome 10.3 B2M PTGS2
18 peyronie's disease 10.3 CCL2 SMAD3 TGFB1
19 peritonitis 10.3 ALB B2M CCL2
20 hypertension, diastolic 10.3 GGT1 REN
21 gastrointestinal system cancer 10.3 ALB PIK3CA PTGS2
22 interstitial nephritis 10.2 ALB REN UMOD
23 squamous cell carcinoma, head and neck 10.2 EGF PIK3CA PTGS2 TGFB1
24 orthostatic proteinuria 10.2 ALB B2M REN
25 chagas disease 10.2 CCL2 SMAD2 TGFB1
26 arteries, anomalies of 10.2 ALB CCL2 REN
27 idiopathic hypercalciuria 10.2 NAGLU REN SLPI
28 penile disease 10.2 SMAD2 SMAD3 TGFB1
29 kidney papillary necrosis 10.2 ALB REN
30 hypertrophic scars 10.2 SMAD2 SMAD3 TGFB1
31 obstructive jaundice 10.2 ALB GGT1 REN
32 ureteral obstruction 10.2 AQP2 PTGS2 TGFB1
33 keloids 10.2 SMAD2 SMAD3 TGFB1
34 hepatitis b 10.2 ALB GGT1 PIK3CA TGFB1
35 nephrosclerosis 10.2 CCL2 CTGF TGFB1
36 gastrointestinal system disease 10.2 ALB GGT1 PTGS2
37 acquired metabolic disease 10.2 ALB CCL2 REN
38 urethritis 10.1
39 sialolithiasis 10.1 ALB CTGF TGFB1
40 vitreoretinopathy, neovascular inflammatory 10.1 CCL2 CTGF TGFB1
41 idiopathic interstitial pneumonia 10.1 CCL2 CTGF TGFB1
42 biliary atresia 10.1 ALB CTGF TGFB1
43 pauci-immune glomerulonephritis 10.1 CTGF SMAD2
44 acute kidney failure 10.1 ALB B2M EGF REN
45 hepatorenal syndrome 10.1 ALB AQP2 REN
46 iga glomerulonephritis 10.0 ALB CCL2 NAGLU REN TGFB1
47 clear cell adenocarcinoma 10.0 KLK3 SMAD2 SMAD3
48 ascending cholangitis 10.0 ALB PKDREJ TGFB1
49 xanthogranulomatous pyelonephritis 10.0 CCL2 EGF PKDREJ
50 prostatitis 10.0

Comorbidity relations with Urinary Tract Obstruction via Phenotypic Disease Network (PDN): (show all 21)


Acute Cystitis Acute Kidney Failure
Bladder Cancer Bladder Neck Obstruction
Chronic Kidney Failure Chronic Myocardial Ischemia
Decubitus Ulcer Deficiency Anemia
Familial Atrial Fibrillation Heart Disease
Hydronephrosis Kidney Disease
Nephrolithiasis, X-Linked Recessive, with Renal Failure Paralytic Ileus
Prostate Calculus Prostate Cancer
Prostatic Hypertrophy Prostatitis
Protein-Energy Malnutrition Ureterolithiasis
Urethral Stricture

Graphical network of the top 20 diseases related to Urinary Tract Obstruction:



Diseases related to Urinary Tract Obstruction

Symptoms & Phenotypes for Urinary Tract Obstruction

UMLS symptoms related to Urinary Tract Obstruction:


urologic problem, other and unspecified genitourinary symptoms, renal pain, bladder discomfort, uti symptoms, burning urination, urinary tenesmus, difficulty passing urine, flank tenderness, ureteral pain, loin pain, urethral burning on micturition, renal colic, pain in urethra, urgency of micturition, polyuria, dysuria

MGI Mouse Phenotypes related to Urinary Tract Obstruction:

43 (show all 15)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.37 GGT1 SMAD2 TGFB1 HBEGF CTGF AQP2
2 homeostasis/metabolism MP:0005376 10.35 B2M GGT1 SLPI SMAD2 TGFB1 CTGF
3 behavior/neurological MP:0005386 10.33 SLC5A6 SMAD3 GGT1 SMAD2 TGFB1 AQP2
4 immune system MP:0005387 10.3 B2M GGT1 SLPI SMAD2 CCL2 TGFB1
5 cardiovascular system MP:0005385 10.28 SLC5A6 SMAD3 B2M SMAD2 CTGF TGFB1
6 endocrine/exocrine gland MP:0005379 10.25 SMAD3 B2M GGT1 SMAD2 CTGF TGFB1
7 mortality/aging MP:0010768 10.24 B2M GGT1 SLPI SMAD2 CTGF TGFB1
8 integument MP:0010771 10.21 SMAD2 TGFB1 HBEGF CTGF AQP2 EGF
9 digestive/alimentary MP:0005381 10.18 SLC5A6 SMAD3 B2M SMAD2 CTGF TGFB1
10 liver/biliary system MP:0005370 10.06 SLC5A6 SMAD3 B2M SMAD2 CTGF TGFB1
11 renal/urinary system MP:0005367 9.96 GGT1 TGFB1 ALB AQP2 SMAD3 UMOD
12 reproductive system MP:0005389 9.9 B2M GGT1 SMAD2 TGFB1 EGF AQP2
13 neoplasm MP:0002006 9.87 SMAD3 B2M ALB SMAD2 TGFB1 PIK3CA
14 skeleton MP:0005390 9.7 GGT1 SMAD2 CTGF TGFB1 SLC5A6 SMAD3
15 vision/eye MP:0005391 9.28 SMAD3 GGT1 SMAD2 CTGF TGFB1 EGF

Drugs & Therapeutics for Urinary Tract Obstruction

Drugs for Urinary Tract Obstruction (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 53)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tamsulosin Approved, Investigational Phase 4,Phase 3,Phase 2 106133-20-4 129211
2 Adrenergic Agents Phase 4,Phase 3,Phase 2
3 Adrenergic alpha-1 Receptor Antagonists Phase 4,Phase 3,Phase 2
4 Adrenergic alpha-Antagonists Phase 4,Phase 3,Phase 2
5 Adrenergic Antagonists Phase 4,Phase 3,Phase 2
6 Neurotransmitter Agents Phase 4,Phase 3,Phase 2
7 Cholinergic Agents Phase 4
8 Cholinergic Antagonists Phase 4
9 Muscarinic Antagonists Phase 4
10 Tolterodine tartrate Phase 4 124937-52-6
11
Indomethacin Approved, Investigational Phase 3 53-86-1 3715
12 Anti-Bacterial Agents Phase 3
13 Antibiotics, Antitubercular Phase 3
14 Anti-Infective Agents Phase 3
15 Analgesics Phase 3
16 Analgesics, Non-Narcotic Phase 3
17 Anti-Inflammatory Agents Phase 3,Phase 2
18 Anti-Inflammatory Agents, Non-Steroidal Phase 3
19 Antirheumatic Agents Phase 3
20 Arginine Vasopressin Phase 3
21 Coagulants Phase 3
22 Cyclooxygenase Inhibitors Phase 3
23 Deamino Arginine Vasopressin Phase 3
24 Hemostatics Phase 3
25 Natriuretic Agents Phase 3
26 Peripheral Nervous System Agents Phase 3
27 Tocolytic Agents Phase 3
28 Vasopressins Phase 3
29 carnitine Nutraceutical Phase 3
30 Omega 3 Fatty Acid Nutraceutical Phase 3
31 arginine Nutraceutical Phase 3
32
Prednisone Approved, Vet_approved Phase 2 53-03-2 5865
33
Tamoxifen Approved Phase 2 10540-29-1 2733526
34
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 2 437-38-7 3345
35
Pancuronium Approved Phase 2 15500-66-0 441289 27350
36 Antineoplastic Agents, Hormonal Phase 2
37 Bone Density Conservation Agents Phase 2
38 Estrogen Antagonists Phase 2
39 Estrogen Receptor Modulators Phase 2
40 Estrogens Phase 2
41 glucocorticoids Phase 2
42 Hormone Antagonists Phase 2
43 Hormones Phase 2
44 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
45 Selective Estrogen Receptor Modulators Phase 2
46 Anesthetics Phase 2
47
Cisplatin Approved 15663-27-1 2767 441203 84093
48 Cariostatic Agents
49 Fluorides
50 Protective Agents

Interventional clinical trials:

(show all 26)

# Name Status NCT ID Phase Drugs
1 Functional MR Urography Completed NCT00301470 Phase 4
2 Treatment of Symptoms After Stent Placement for Urinary Tract Obstruction Active, not recruiting NCT01741454 Phase 4 Tamsulosin;Tolterodine ER
3 L-carnitine on the Prevention of Renal Scarring in Acute Pyelonephritis Unknown status NCT02007889 Phase 3 L-carnitine
4 Oral Omega-3 for Reduction of Kidney Scar Due to Pyelonephritis in Children Unknown status NCT02192580 Phase 3 Omega-3
5 Analgesic Efficacy of Intranasal Desmopressin in Acute Renal Colic Unknown status NCT01742689 Phase 3 Desmopressin intranasal spray;Placebo intranasal spray;Indomethacin suppository
6 Evaluation of the Efficacy of Tamsulosin (Alpha Blockers) Compared to Phloroglucinol in Improving JJ Ureteral Stent Tolerance. A Randomized Controlled Trial Completed NCT01061073 Phase 3 Omexel;spasfon
7 Transobturator Subtrigonal Tape vs Transobturator Suburethral Tape for Stress Urinary Incontinence Recruiting NCT02112591 Phase 3
8 Prednisone Versus Tamoxifen in Idiopathic Retroperitoneal Fibrosis Unknown status NCT00440349 Phase 2 Tamoxifen;Prednisone
9 Study of FLOMAX® Versus Placebo in Female Patients With Lower Urinary Tract Symptoms (LUTS) With a Significant Component of Voiding Symptoms Completed NCT02244281 Phase 2 tamsulosin hydrochloride;Placebo
10 Use of Autologous Adipose-Derived Stem/Stromal Cells (AD-cSVF) in Symptomatic Benign Prostate Hypertrophy Recruiting NCT02961114 Phase 1, Phase 2
11 Fetal Cystoscopy Versus Vesico-amniotic Shunting in Severe Lower Urinary Tract Obstructions Not yet recruiting NCT01552824 Phase 2
12 Delayed or Direct Ureteroscopy in the Treatment of Pediatric Calcular Anuria Unknown status NCT02139059
13 Early Versus Late Catheter Removal in Patients With Acute Urinary Retention Secondary to BPH Under Tamsulosin Treatment Completed NCT03280420
14 Dismembered Pyeloplasty With and Without After Coming Stent Completed NCT02138877
15 Ureteral Stents Versus Percutaneous Nephrostomy for Initial Urinary Drainage Completed NCT02055430
16 Acute Kidney Outreach to Reduce Deterioration and Death (AKORDD) Completed NCT02398682
17 Fetal Cystoscopy for Severe Lower Urinary Tract Obstruction (LUTO) Recruiting NCT03281798
18 Standardized Prenatal Clinical Care for LUTO Recruiting NCT02315521
19 Prostatic Artery Embolization for Obstructive Uropathy Due to Locally Advanced Prostate Cancer Recruiting NCT03104907
20 Prostate Artery Embolization for the Treatment of Symptomatic Benign Prostatic Hyperplasia Recruiting NCT03055624
21 Indwelling Stent Discoloration Project Recruiting NCT02007980
22 Green LEP vs ThuLEP vs HoLEP in Management of Marked Enlarged Prostate Active, not recruiting NCT03305861
23 Advanced Genital Prolapse Surgery With and Without Mid Urethral Sling to Prevent Stress Urinary Incontinence Enrolling by invitation NCT02578056
24 Fetal Cystoscopy for Lower Urinary Tract Obstruction Terminated NCT02446184
25 Tc-99m Renography and Cisplatin-induced Nephrotoxicity Terminated NCT00213642
26 Functional, Dynamic, and Anatomic MR Urography Withdrawn NCT00585767

Search NIH Clinical Center for Urinary Tract Obstruction

Genetic Tests for Urinary Tract Obstruction

Anatomical Context for Urinary Tract Obstruction

MalaCards organs/tissues related to Urinary Tract Obstruction:

38
Prostate, Kidney, Bone, Testes, Lung, Smooth Muscle, Neutrophil

Publications for Urinary Tract Obstruction

Articles related to Urinary Tract Obstruction:

(show top 50) (show all 348)
# Title Authors Year
1
Successful medical management of pseudomembranous cystitis in three cats with lower urinary tract obstruction. ( 29226304 )
2018
2
Combined prostatic urethral lift and remodeling of the prostate and bladder neck: a modified transurethral approach in the treatment of symptomatic lower urinary tract obstruction. ( 29450732 )
2018
3
Fetal surgery for lower urinary tract obstruction: the importance of staging prior to intervention. ( 29160637 )
2017
4
Natural History of Fetal Lower Urinary Tract Obstruction with Normal Amniotic Fluid Volume at Initial Diagnosis. ( 28700992 )
2017
5
Influence of bladder fullness on the detection of urinary tract obstruction by dynamic renal scintigraphy. ( 28894331 )
2017
6
Forkhead box O3 (FoxO3) regulates kidney tubular autophagy following urinary tract obstruction. ( 28705935 )
2017
7
Diagnostic value of 64-slice spiral computed tomography imaging of the urinary tract during the excretory phase for urinary tract obstruction. ( 29201177 )
2017
8
Lower urinary tract obstruction: fetal intervention based on prenatal staging. ( 28730376 )
2017
9
Three-dimensional virtual cystoscopy: Noninvasive approach for the assessment of urinary tract in fetuses with lower urinary tract obstruction. ( 29178428 )
2017
10
Ultrasound guided balloon catheterisation: a new method of fetal lower urinary tract obstruction management. ( 28580571 )
2017
11
Spontaneous rupture of the renal pelvis caused by upper urinary tract obstruction: A case report and review of the literature. ( 29390332 )
2017
12
Can bladder fibrosis in congenital urinary tract obstruction be reversed? ( 29037864 )
2017
13
Complete upper urinary tract obstruction caused by penetrating pellet injury of the ureterintroduction. ( 28513528 )
2017
14
Early vesico-amniotic shunting - does it change the prognosis in fetal lower urinary tract obstruction diagnosed in the first trimester? ( 29057434 )
2017
15
Analysis of Preoperative Urinary Tract Obstruction in Patients with Scoliosis. ( 27507671 )
2016
16
Urinary tract obstruction: NLRP3 inhibition prevents BOO. ( 26754189 )
2016
17
Are ultrasound renal aspects associated with urinary biochemistry in fetuses with lower urinary tract obstruction? ( 27862070 )
2016
18
Vesico-amniotic shunting for lower urinary tract obstruction in a fetus with VACTERL association. ( 27061706 )
2016
19
Effectiveness of vesico-amniotic shunt in fetuses with congenital lower urinary tract obstruction: An updated systematic review and meta-analysis. ( 27270578 )
2016
20
Urinary tract obstruction: Stem cells hinder stricture formation. ( 27349369 )
2016
21
Use of an Amnioport to Maintain Amniotic Fluid Volume in Fetuses with Oligohydramnios Secondary to Lower Urinary Tract Obstruction or Fetal Renal Anomalies. ( 27287190 )
2016
22
Factors associated with fetal shunt dislodgement in lower urinary tract obstruction. ( 27247093 )
2016
23
Sequential fetal serum I^2-microglobulin to predict postnatal renal function in bilateral or low urinary tract obstruction. ( 27197901 )
2016
24
Fetal Serum I^2-Microglobulin and Postnatal Renal Function in Lower Urinary Tract Obstruction Treated with Vesicoamniotic Shunt. ( 27603215 )
2016
25
Anterior Urethral Valve: A Rare But an Important Cause of Infravesical Urinary Tract Obstruction. ( 27231492 )
2016
26
Lower urinary tract obstruction in male children - a report of three cases. ( 27622420 )
2016
27
EP21.11: Prediction of shunt dislodgement in fetuses with lower urinary tract obstruction. ( 27646514 )
2016
28
Two-year outcomes after diagnostic and therapeutic fetal cystoscopy for lower urinary tract obstruction. ( 26739350 )
2016
29
Current applications of in utero intervention for lower urinary tract obstruction. ( 26441047 )
2015
30
Defining and predicting 'intrauterine fetal renal failure' in congenital lower urinary tract obstruction. ( 26525197 )
2015
31
Congenital urinary tract obstruction: the long view. ( 26088076 )
2015
32
Fetal Lower Urinary Tract Obstruction (LUTO): a practical review for providers. ( 27057343 )
2015
33
Postobstructive diuresis in cats with naturally occurring lower urinary tract obstruction: incidence, severity and association with laboratory parameters on admission. ( 26179575 )
2015
34
Re: Fetal intervention for severe lower urinary tract obstruction: a multicenter case-control study comparing fetal cystoscopy with vesicoamniotic shunting. R. Ruano, N. Sananes, H. Sangi-Haghpeykar, S. Hernandez-Ruano, R. Moog, F. Becmeur, A. Zaloszyc, A. M. Giron, B. Morin and R. Favre. Ultrasound Obstet Gynecol 2015; 45: 452-458. ( 25833370 )
2015
35
Fetal Lower Urinary Tract Obstruction - A proposal of Standardized Multidisciplinary Prenatal Management based on Disease Severity. ( 26690832 )
2015
36
Outcome in fetal lower urinary tract obstruction: a prospective registry. ( 25689128 )
2015
37
Fetal intervention for severe lower urinary tract obstruction: a multicenter case-control study comparing fetal cystoscopy with vesico-amniotic shunting. ( 25157756 )
2014
38
Palliative management of malignant upper urinary tract obstruction. ( 26052193 )
2014
39
Fetal urine biochemistry at 13-23 weeks in low urinary tract obstruction: criteria for in utero treatment. ( 25412852 )
2014
40
Pathological feature and immunoprofile of cystitis glandularis accompanied with upper urinary tract obstruction. ( 25136635 )
2014
41
Lower urinary tract obstruction in the fetus and neonate. ( 25155733 )
2014
42
Laparoscopic ureterocalicostomy for complicated upper urinary tract obstruction: mid-term follow-up. ( 24217801 )
2013
43
Erdheim-Chester disease: an uncommon cause of upper urinary tract obstruction. ( 24088590 )
2013
44
Urinary tract obstruction in the mouse: the kinetics of distal nephron injury. ( 23917879 )
2013
45
Monosodium glutamate (MSG) consumption is associated with urolithiasis and urinary tract obstruction in rats. ( 24086562 )
2013
46
Postmortem high-resolution fetal magnetic resonance imaging in three cases of lower urinary tract obstruction. ( 23752166 )
2013
47
Epidermal growth factor and monocyte chemotactic peptide-1: potential biomarkers of urinary tract obstruction in children with hydronephrosis. ( 23228281 )
2013
48
Prenatal cytogenetic diagnosis from fetal urine in lower urinary tract obstruction. ( 23751043 )
2013
49
Microtomographic analysis of lower urinary tract obstruction. ( 23977847 )
2013
50
The experience of pregnant women with a diagnosis of fetal lower urinary tract obstruction (LUTO). ( 24290423 )
2013

Variations for Urinary Tract Obstruction

Expression for Urinary Tract Obstruction

Search GEO for disease gene expression data for Urinary Tract Obstruction.

Pathways for Urinary Tract Obstruction

Pathways related to Urinary Tract Obstruction according to GeneCards Suite gene sharing:

(show all 38)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.32 B2M CCL2 EGF HBEGF PIK3CA PTGS2
2
Show member pathways
12.99 EGF KLK3 PIK3CA SMAD2 SMAD3 TGFB1
3
Show member pathways
12.97 CCL2 CTGF EGF HBEGF PTGS2 REN
4
Show member pathways
12.71 EGF PIK3CA SMAD2 SMAD3 TGFB1
5 12.67 EGF KLK3 PIK3CA PTGS2 SMAD2 SMAD3
6
Show member pathways
12.5 HBEGF PIK3CA SMAD2 SMAD3 TGFB1
7
Show member pathways
12.46 CCL2 PIK3CA SMAD2 SMAD3 TGFB1
8 12.37 PIK3CA SMAD2 SMAD3 TGFB1
9
Show member pathways
12.27 ALB CCL2 GGT1 PTGS2
10 12.23 HBEGF PIK3CA SMAD2 TGFB1
11 12.17 CTGF SMAD2 SMAD3 TGFB1
12 12.1 PIK3CA SMAD2 SMAD3 TGFB1
13 12.08 CTGF SMAD2 SMAD3 TGFB1
14 12.07 EGF PTGS2 SMAD2 SMAD3 TGFB1
15 12.04 GGT1 HBEGF SLC5A6 TGFB1
16
Show member pathways
11.95 EGF PIK3CA SMAD2 SMAD3 TGFB1
17 11.83 EGF HBEGF TGFB1
18 11.83 SMAD2 SMAD3 TGFB1
19
Show member pathways
11.81 SMAD2 SMAD3 TGFB1
20
Show member pathways
11.8 SMAD2 SMAD3 TGFB1
21
Show member pathways
11.79 EGF PIK3CA SMAD2 SMAD3 TGFB1
22 11.76 SMAD2 SMAD3 TGFB1
23 11.76 CCL2 PTGS2 REN TGFB1
24
Show member pathways
11.71 SMAD2 SMAD3 TGFB1
25 11.68 SMAD2 SMAD3 TGFB1
26
Show member pathways
11.65 SMAD2 SMAD3 TGFB1
27 11.62 EGF SMAD3 TGFB1
28
Show member pathways
11.6 EGF HBEGF KLK3 PIK3CA SMAD3 TGFB1
29 11.58 CCL2 CTGF EGF TGFB1
30 11.55 CCL2 PIK3CA SMAD2 SMAD3 TGFB1
31 11.5 EGF SMAD2 SMAD3 TGFB1
32 11.49 PTGS2 SMAD3 TGFB1
33 11.33 CTGF SMAD2 SMAD3 TGFB1
34 11.21 SMAD2 SMAD3 TGFB1
35 11.11 CTGF SMAD2 SMAD3
36 11.1 CCL2 HBEGF PIK3CA
37 10.93 SMAD2 SMAD3 TGFB1
38
Show member pathways
10.79 EGF HBEGF PIK3CA SMAD2 SMAD3 TGFB1

GO Terms for Urinary Tract Obstruction

Cellular components related to Urinary Tract Obstruction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.7 ALB B2M CCL2 CTGF EGF HBEGF
2 platelet alpha granule lumen GO:0031093 9.43 ALB EGF TGFB1
3 extracellular space GO:0005615 9.36 ALB B2M CCL2 CTGF EGF GGT1
4 SMAD protein complex GO:0071141 9.32 SMAD2 SMAD3
5 heteromeric SMAD protein complex GO:0071144 9.16 SMAD2 SMAD3

Biological processes related to Urinary Tract Obstruction according to GeneCards Suite gene sharing:

(show all 39)
# Name GO ID Score Top Affiliating Genes
1 MAPK cascade GO:0000165 9.98 CCL2 EGF HBEGF TGFB1
2 positive regulation of gene expression GO:0010628 9.97 CTGF EGF SMAD2 SMAD3 TGFB1
3 positive regulation of cell migration GO:0030335 9.89 EGF HBEGF SMAD3 TGFB1
4 transforming growth factor beta receptor signaling pathway GO:0007179 9.85 SMAD2 SMAD3 TGFB1
5 wound healing GO:0042060 9.85 SMAD2 SMAD3 TGFB1
6 response to organic substance GO:0010033 9.84 PTGS2 REN TGFB1
7 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.83 EGF HBEGF TGFB1
8 positive regulation of protein kinase B signaling GO:0051897 9.83 EGF HBEGF PIK3CA TGFB1
9 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.82 PIK3CA PTGS2 TGFB1
10 response to glucose GO:0009749 9.81 CTGF SMAD2 TGFB1
11 cell chemotaxis GO:0060326 9.8 CCL2 HBEGF PIK3CA
12 negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 9.78 SMAD2 SMAD3 TGFB1
13 SMAD protein signal transduction GO:0060395 9.76 SMAD2 SMAD3 TGFB1
14 angiogenesis GO:0001525 9.72 CCL2 CTGF EGF PIK3CA PTGS2
15 protein kinase B signaling GO:0043491 9.71 CCL2 PIK3CA TGFB1
16 positive regulation of epithelial to mesenchymal transition GO:0010718 9.69 SMAD2 SMAD3 TGFB1
17 negative regulation of ERBB signaling pathway GO:1901185 9.67 EGF HBEGF
18 ureteric bud development GO:0001657 9.67 SMAD2 SMAD3 TGFB1
19 positive regulation of SMAD protein import into nucleus GO:0060391 9.66 SMAD3 TGFB1
20 lens fiber cell differentiation GO:0070306 9.65 SMAD3 TGFB1
21 positive regulation of catenin import into nucleus GO:0035413 9.64 EGF SMAD3
22 response to cholesterol GO:0070723 9.64 SMAD2 TGFB1
23 ERBB2 signaling pathway GO:0038128 9.63 EGF HBEGF PIK3CA
24 primary miRNA processing GO:0031053 9.62 SMAD2 SMAD3
25 embryonic foregut morphogenesis GO:0048617 9.62 SMAD2 SMAD3
26 pericardium development GO:0060039 9.61 SMAD2 SMAD3
27 endoderm development GO:0007492 9.61 SMAD2 SMAD3 TGFB1
28 nodal signaling pathway GO:0038092 9.58 SMAD2 SMAD3
29 common-partner SMAD protein phosphorylation GO:0007182 9.56 SMAD2 TGFB1
30 regulation of striated muscle tissue development GO:0016202 9.55 SMAD3 TGFB1
31 positive regulation of extracellular matrix assembly GO:1901203 9.48 SMAD3 TGFB1
32 epidermal growth factor receptor signaling pathway GO:0007173 9.46 EGF HBEGF PIK3CA TGFB1
33 regulation of transforming growth factor beta receptor signaling pathway GO:0017015 9.43 SMAD2 SMAD3 TGFB1
34 paraxial mesoderm morphogenesis GO:0048340 9.4 SMAD2 SMAD3
35 evasion or tolerance of host defenses by virus GO:0019049 9.37 SMAD3 TGFB1
36 SMAD protein complex assembly GO:0007183 9.13 SMAD2 SMAD3 TGFB1
37 regulation of binding GO:0051098 8.8 SMAD2 SMAD3 TGFB1
38 positive regulation of cell proliferation GO:0008284 10.06 CTGF EGF HBEGF PTGS2 TGFB1
39 negative regulation of cell proliferation GO:0008285 10 PTGS2 SMAD2 SMAD3 TGFB1 UMOD

Molecular functions related to Urinary Tract Obstruction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.5 EGF HBEGF PIK3CA
2 growth factor activity GO:0008083 9.46 CTGF EGF HBEGF TGFB1
3 enhancer binding GO:0035326 9.43 SMAD2 SMAD3
4 co-SMAD binding GO:0070410 9.4 SMAD2 SMAD3
5 type I transforming growth factor beta receptor binding GO:0034713 9.37 SMAD2 TGFB1
6 primary miRNA binding GO:0070878 9.26 SMAD2 SMAD3
7 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity GO:0030618 8.96 SMAD2 SMAD3
8 transforming growth factor beta receptor binding GO:0005160 8.8 SMAD2 SMAD3 TGFB1

Sources for Urinary Tract Obstruction

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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