Urolithiasis malady

Wikipedia: Urolithiasis (from Greek oûron, \"urine\" and lithos, \"stone\") is the condition where urinary calculi...⁴⁴ more...

MalaCards: Urolithiasis is related to adenine phosphoribosyltransferase deficiency and acute urate nephropathy. An important gene associated with Urolithiasis is APRT (adenine phosphoribosyltransferase), and among its related pathways are Metabolism of amino acids and derivatives and Selected targets of ESR1. The compounds hyaluronic acid and oxalate have been mentioned in the context of this disorder. Affiliated tissues include kidney and t cells, and related mouse phenotypes are endocrine/exocrine gland and hematopoietic system.

urolithiasis 7 32 43

Diseases related to urolithiasis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 563)

id	Related Disease	Score	Top Affiliating Genes
1	adenine phosphoribosyltransferase deficiency	32.0	XDH, APRT, HPRT1
2	acute urate nephropathy	29.9	XDH, HPRT1
3	nephrocalcinosis	29.4	NAGLU, UMOD, XDH, ALB, CASR, CA2
4	primary hyperoxaluria	28.6	SPP1, AGXT
5	lesch-nyhan syndrome	28.3	XDH, APRT, HPRT1, PRPS1
6	hydronephrosis	27.2	NAGLU, MME, IL6, AMBP
7	nephrolithiasis	24.7	NAGLU, VDR, UMOD, XDH, MME, IL1B
8	osteoporosis	21.4	VDR, AR, IL1A, IL1B, IL1RN, IL6
9	interstitial nephritis	13.8	UMOD, APRT
10	urinary tract obstruction	13.7	NAGLU, UMOD, AMBP
11	asphyxia neonatorum	13.7	NAGLU, CKB, XDH
12	familial juvenile hyperuricemic nephropathy	13.6	UMOD, HPRT1
13	hypercalciuria, absorptive	13.5	VDR, CASR
14	purine nucleoside phosphorylase deficiency	13.5	APRT, HPRT1, PRPS1
15	phosphoribosylpyrophosphate synthetase superactivity	13.5	HPRT1, PRPS1
16	purine-pyrimidine metabolic disorder	13.5	APRT, HPRT1
17	gout	13.5	UMOD, HPRT1
18	familial hypophosphatemia	13.5	VDR, MME, SLC34A1
19	renal tubular acidosis	13.4	UMOD, AMBP, CA2, SLC26A1
20	lacrimal duct obstruction	13.4	UMOD, XDH, AMBP, TTF2
21	hypertensive nephropathy	13.3	NAGLU, AMBP, ALB
22	chronic pyelonephritis	13.3	NAGLU, UMOD, ALB
23	lepromatous leprosy	13.3	VDR, IL1RN, F2
24	calciphylaxis	13.3	ALB, CASR, SPP1
25	hypouricemia	13.2	XDH, ALB, HPRT1
26	fanconi syndrome	13.2	NAGLU, AMBP, ALB
27	esophageal varix	13.2	F2, ALB
28	bilirubin metabolic disorder	13.2	XDH, APRT, CA2, AGXT, TTF2
29	secondary hyperparathyroidism of renal origin	13.2	VDR, ALB, CASR
30	acute kidney tubular necrosis	13.2	AMBP, ALB, NPPA
31	twin-to-twin transfusion syndrome	13.2	AMBP, ALB, NPPA
32	twin twin transfusion syndrome	13.2	AMBP, ALB, NPPA
33	alcoholic pancreatitis	13.2	XDH, NQO1, SOD2
34	warfarin resistance	13.2	F2, ALB, TTF2
35	autoimmune myocarditis	13.1	CCL2, SPP1, NPPA
36	gastric cancer risk after h. pylori infection	13.1	IL1B, IL1RN
37	chronic rapidly progressive glomerulonephritis	13.1	NAGLU, AMBP, ALB, NPPA
38	mayer-rokitansky-kuster-hauser syndrome	13.1	VDR, APRT, CASR, HPRT1, AGXT, SOX9
39	diabetic angiopathy	13.1	NAGLU, CCL2, SOD2
40	hyperphosphatemia	13.0	VDR, ALB, CASR, SPP1, SLC34A1
41	portal vein thrombosis	13.0	F2, ALB, TTF2
42	hypocalcemia	13.0	VDR, ALB, CASR
43	osteoporosis, postmenopausal	13.0	VDR, IL1RN, ESR1
44	steroid-resistant nephrotic syndrome	13.0	NAGLU, CCL2, ALB
45	lipoid nephrosis	13.0	NAGLU, CCL2, ALB, SPP1
46	glycogen storage disease	13.0	NAGLU, CKM, F2, ALB
47	hepatorenal syndrome	13.0	NAGLU, F2, ALB, NPPA
48	interstitial lung disease	13.0	IL1A, IL1RN, CCL2
49	primary biliary cirrhosis	12.9	VDR, F2, ALB, CA2
50	aortic valve stenosis	12.9	VDR, MME, CCL2, NPPA

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to urolithiasis:

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MGI Mouse Phenotypes related to urolithiasis:

²⁵ (show all 19)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	9.9	XDH, SOX9, HPRT1
2	hematopoietic system phenotype	MP:0005397	9.4	SOX9, SOD2, NQO1, HPRT1, APRT, CASR
3	integument phenotype	MP:0010771	9.1	F2, HPRT1, NQO1, XDH, MME, APRT
4	nervous system phenotype	MP:0003631	8.8	SOX9, F2, NAGLU, SPP1, PLAU, HPRT1
5	liver/biliary system phenotype	MP:0005370	8.8	NQO1, HPRT1, IL6, AR, SLC26A1
6	reproductive system phenotype	MP:0005389	7.9	HPRT1, SOD2, CCL2, IL6, VDR, SLC34A1
7	renal/urinary system phenotype	MP:0005367	7.9	UMOD, NAGLU, AR, APRT, CASR, HPRT1
8	immune system phenotype	MP:0005387	7.7	F2, HPRT1, NQO1, SOD2, SOX9, SLC26A1
9	skeleton phenotype	MP:0005390	7.4	AR, CASR, ESR1, SPP1, SLC34A1, SLC9A3R1
10	growth/size phenotype	MP:0005378	7.3	SPP1, PLAU, CA2, APRT, AR, XDH
11	behavior/neurological phenotype	MP:0005386	7.3	AMBP, SOD2, NAGLU, IL6, APRT, SLC9A3R1
12	adipose tissue phenotype	MP:0005375	7.0	IL6, SOD2, PLAU, NQO1, ESR1, CCL2
13	tumorigenesis	MP:0002006	6.2	SOD2, SPP1, IL1A, PLAU, IL1B, IL6
14	muscle phenotype	MP:0005369	6.2	AR, SLC34A1, IL6, NPPA, SOX9, SOD2
15	digestive/alimentary phenotype	MP:0005381	5.9	VDR, CASR, CA2, ESR1, PLAU, SOX9
16	cellular phenotype	MP:0005384	5.3	F2, CASR, ESR1, NQO1, PLAU, SOD2
17	cardiovascular system phenotype	MP:0005385	4.9	CCL2, NAGLU, IL6, IL1RN, IL1B, IL1A
18	mortality/aging	MP:0010768	4.1	HPRT1, ESR1, SOD2, CASR, SPP1, SOX9
19	homeostasis/metabolism phenotype	MP:0005376	2.6	GGCX, CCL2, APRT, IL6, IL1RN, IL1B

Articles related to urolithiasis:

(show top 50)    (show all 58)

id	Title	Authors	Year	Affiliating Genes
1	Primary hyperoxaluria type III gene HOGA1 (formerly D HDPSL) as a possible risk factor for idiopathic calcium oxalate urolithiasis. (21896830)	Monico C.G.... Milliner D.S.	2011	HOGA1
2	Vitamin D receptor genetic polymorphisms and the risk of urolithiasis: a meta-analysis. (21325790)	Lin Y.... Xie L.	2011	VDR
3	The impact of osteopontin promoter polymorphisms on t he risk of calcium urolithiasis. (20144595)	Liu C.C.... Wu M.T.	2010	SPP1
4	Urolithiasis and hepatotoxicity are linked to the ani on transporter Sat1 in mice. (20160351)	Dawson P.A.... Markovich D.	2010	SLC26A1
5	Xanthine urolithiasis. (20228523)	Gargah T.... Lakhoua M.R.	2010	XDH
6	Activity and expression of vitamin K-dependent gamma- glutamyl carboxylase in patients with calcium oxalate urolithiasis. (20332604)	Wang T.... Ye Z.	2010	GGCX
7	Urolithiasis and osteoporosis: clinical relevance and therapeutic implications. (20120412)	BiliA8-CurciA8 I.... Tucak-ZoriA8 S.	2009	SPP1
8	A novel SOX9 mutation, 972delC, causes 46,XY sex-reversed campomelic dysplasia with nephrocalcinosis, urolithiasis, and dysgerminoma. (19231556)	Cost N.G.... Baker L.A.	2009	SOX9
9	Genetic mutation of vitamin K-dependent gamma-glutamy l carboxylase domain in patients with calcium oxalate urolithiasis. (19821094)	Qiao J.... Ye Z.	2009	GGCX
10	Association of urokinase gene 3'-UTR T/C polymorphism with calcium oxalate urolithiasis in children. (18240004)	Ozturk M.... Oktay B.	2008	PLAU
11	Urine fetuin-A values in relation to the presence of urolithiasis. (18190622)	Stejskal D.... Stejskal P.	2008	ALB
12	Manganese superoxide dismutase (Mn-SOD) gene polymorphisms in urolithiasis. (17628794)	Tugcu V.... Tasci A.I.	2007	SOD2
13	Xanthinuria type I: a rare cause of urolithiasis. (17115198)	Arikyants N.... Steinmann B.	2007	XDH
14	Association of vitamin D receptor gene Taq I polymorphism with recurrent urolithiasis in children. (18036039)	Seyhan S.... Kordan Y.	2007	VDR
15	Association of vitamin D receptor (Fok-I) polymorphism with the clinical presentation of calcium urolithiasis. (17419705)	Liu C.C.... Wu M.T.	2007	VDR
16	Association of interleukin-1beta gene and receptor antagonist polymorphisms with calcium oxalate urolithiasis. (18186699)	Mittal R.D.... Kapoor R.	2007	IL1B, IL1RN
17	Xanthine urolithiasis in a cat: a case report and evaluation of a candidate gene for xanthine dehydrogenase. (17576085)	Tsuchida S.... Tagawa M.	2007	XDH
18	Acute renal failure due to bilateral xanthine urolithiasis in a boy with Lesch-Nyhan syndrome. (16773422)	Sikora P.... Zajczkowska M.	2006	HPRT1
19	Vitamin D receptor gene polymorphisms in patients with urolithiasis. (16397775)	Gunes S.... Yilmaz A.F.	2006	VDR
20	Is idiopathic recurrent calcium urolithiasis in males a cellular disease? Laboratory findings in plasma, urine and erythrocytes, emphasizing the absence and presence of stones, oxidative and mineral metabolism: an observational study. (16006254)	Schwille P.O.... Schmiedl A.	2005	ALB
21	Is calcium oxalate nucleation in postprandial urine o f males with idiopathic recurrent calcium urolithiasis related to calcium phosp hate nucleation and the intensity of stone formation? Studies allowing insight into a possible role of urinary free citrate and protein. (15080561)	Schwille P.O.... Manoharan M.	2004	ALB
22	Three-dimensional structure of human adenine phosphoribosyltransferase and its relation to DHA-urolithiasis. (15196008)	Silva M.... Thiemann O.H.	2004	APRT
23	Surface-enhanced laser desorption/ionization-time of flight-mass spectrometry (SELDI-TOF-MS): a new proteomic urinary test for patients with urolithiasis. (15103681)	Cadieux P.A.... Reid G.	2004	SPP1
24	Identification of two novel mutations in adenine phosphoribosyltransferase gene in patients with 2,8-dihydroxyadenine urolithiasis. (15571218)	Taniguchi A.... Kamatani N.	2004	APRT
25	Urinary NAG in children with urolithiasis, nephrocalcinosis, or risk of urolithiasis. (12920632)	Sikora P.... Hoppe B.	2003	NAGLU
26	Intracrystalline proteins and urolithiasis: a synchrotron X-ray diffraction study of calcium oxalate monohydrate. (12854839)	Fleming D.E.... Ryall R.L.	2003	F2
27	2,8-dihydoroxyadenine (DHA) urolithiasis: a case report (14518391)	Shiba M.... Takatera H.	2003	APRT
28	Association of vitamin D receptor gene polymorphism with urolithiasis. (11956476)	Nishijima S.... Ogawa Y.	2002	VDR
29	Urokinase gene 3'-UTR T/C polymorphism is associated with urolithiasis. (11880102)	Tsai F.J.... Chen W.C.	2002	PLAU
30	The association of androgen- and oestrogen-receptor gene polymorphisms with urolithiasis in men. (11564035)	Chen W.C.... Tsai F.J.	2001	AR, ESR1
31	2,8-Dihydroxyadenine urolithiasis in a patient with considerable residual adenine phosphoribosyltransferase activity in cell extracts but with mutations in both copies of APRT. (11243733)	Deng L.... Sahota A.	2001	APRT
32	Exclusion mapping of major crystallization inhibitors in idiopathic calcium urolithiasis. (11547117)	Cailhier J.F.... Bonnardeaux A.	2001	SPP1, UMOD
33	Analysis of osteopontin DNA in patients with urolithiasis. (10929424)	Yamate T.... Kohri K.	2000	SPP1
34	The prothrombin gene is expressed in the rat kidney: Implications for urolithiasis research. (10601851)	Grover P.K.... Ryall R.L.	2000	F2
35	Circulating adhesion molecules and neutral endopeptidase enzymuria in patients with urolithiasis and hydronephrosis. (10840126)	Huang H.... Chen C.	2000	MME
36	Proteoglycan core protein in human urine and its possible role on calcium oxalate urolithiasis. (10585122)	Yoshimura K.... Okuyama A.	1999	AMBP
37	Urinary IL-6 is elevated in patients with urolithiasis. (9817385)	Rhee E.... Bellman G.C.	1998	IL1A
38	N-acetyl-beta-D-glucosaminidase excretion in healthy children and in pediatric patients with urolithiasis. (9870291)	Balla A.A.... Hesse A.	1998	NAGLU
39	Predisposition towards urolithiasis associated with the NQO1 null-allele. (9825838)	Schulz W.A.... Sies H.	1998	NQO1
40	2,8-dihydroxyadenine urolithiasis due to partial deficiency of adenine phosphoribosyltransferase: a case report (9850838)	Ohne T.... Uchida M.	1998	APRT
41	Nephrocalcinosis and urolithiasis in carbonic anhydrase II deficiency syndrome. (9453381)	Ismail E.A.... Sabry M.A.	1997	CA2
42	A fast and simple screening method for detection of 2,8-dihydroxyadenine urolithiasis by capillary zone electrophoresis. (8646818)	SevcA-k J.... MazA!covA! H.	1996	APRT
43	Blood coagulation proteins and urolithiasis are linked: crystal matrix protein is the F1 activation peptide of human prothrombin. (7613825)	Stapleton A.M.... Ryall R.L.	1995	F2
44	Identification of a 7-basepair deletion in the adenine phosphoribosyltransferase gene as a cause of 2,8-dihydroxyadenine urolithiasis. (7981585)	Bye S.... Sahota A.	1994	APRT
45	Missense mutation in the adenine phosphoribosyltransferase gene causing 2,8-dihydroxyadenine urolithiasis. (7915931)	Sahota A.... Tischfield J.A.	1994	APRT
46	A case of a compound heterozygote for adenine phosphoribosyltransferase deficiency (APRT*J/APRT*Q0) leading to 2,8-dihydroxyadenine urolithiasis: review of the reported cases with 2,8-dihydroxyadenine stones in Japan. (8455250)	Takeuchi H.... Yoshida O.	1993	APRT
47	2,8-Dihydroxyadenine urolithiasis due to partial deficit in adenine phosphoribosyltransferase: a case report. (1609669)	Katsuoka Y.... Ikeda T.	1992	APRT
48	Renal insufficiency secondary to 2,8-dihydroxyadenine urolithiasis. (1516930)	Gelb A.B.... Sibley R.K.	1992	APRT
49	Paediatric urolithiasis in Greece. (2004238)	Androulakakis P.A.... Aghioutantis C.	1991	TTF2
50	Identification of a compound heterozygote for adenine phosphoribosyltransferase deficiency (APRT*J/APART*Q0) leading to 2,8-dihydroxyadenine urolithiasis. (2227934)	Kamatani N.... Hakoda M.	1990	APRT

Genes related to urolithiasis according to GeneCards:

(show all 35)

id	Symbol	Description	Score	GeneCards Section Context
1	APRT	adenine phosphoribosyltransferase	11.1	Publications, Summaries
2	GGCX	gamma-glutamyl carboxylase	11.0	Publications
3	CKM	creatine kinase, muscle	11.0	Publications
4	CKB	creatine kinase, brain	11.0	Publications
5	AGXT	alanine-glyoxylate aminotransferase	11.0
6	UMOD	uromodulin	11.0	Publications
7	AMBP	alpha-1-microglobulin/bikunin precursor	11.0	Publications
8	NAGLU	N-acetylglucosaminidase, alpha	11.0	Publications
9	SPP1	secreted phosphoprotein 1	11.0	Publications
10	VDR	vitamin D (1,25- dihydroxyvitamin D3) receptor	11.0	Publications
11	XDH	xanthine dehydrogenase	11.0	Publications
12	CASR	calcium-sensing receptor	11.0
13	SLC26A1	solute carrier family 26 (sulfate transporter), member 1	11.0	Publications
14	HOGA1	4-hydroxy-2-oxoglutarate aldolase 1	11.0	Publications
15	SLC34A1	solute carrier family 34 (sodium phosphate), member 1	11.0
16	PRPS1	phosphoribosyl pyrophosphate synthetase 1	11.0
17	SOX9	SRY (sex determining region Y)-box 9	11.0	Publications
18	SLC9A3R1	solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1	11.0
19	TTF2	transcription termination factor, RNA polymerase II	11.0	Publications
20	CA2	carbonic anhydrase II	11.0	Publications
21	NQO1	NAD(P)H dehydrogenase, quinone 1	11.0	Publications
22	HPRT1	hypoxanthine phosphoribosyltransferase 1	11.0	Publications
23	MME	membrane metallo-endopeptidase	11.0	Publications
24	SOD2	superoxide dismutase 2, mitochondrial	11.0	Publications
25	IL1RN	interleukin 1 receptor antagonist	11.0	Publications
26	PLAU	plasminogen activator, urokinase	11.0	Publications
27	IL1A	interleukin 1, alpha	11.0	Publications
28	F2	coagulation factor II (thrombin)	11.0	Publications
29	NPPA	natriuretic peptide A	11.0	Publications
30	AR	androgen receptor	11.0	Publications
31	CCL2	chemokine (C-C motif) ligand 2	11.0	Publications
32	IL1B	interleukin 1, beta	11.0	Publications
33	ESR1	estrogen receptor 1	11.0	Publications
34	IL6	interleukin 6 (interferon, beta 2)	11.0	Publications
35	ALB	albumin	11.0	Publications

Pathways related to urolithiasis according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Metabolism of amino acids and derivatives38	9.9	AGXT, CKM, CKB, NQO1
2	Selected targets of ESR110	9.4	SOX9, SLC9A3R1, ESR1, MME
3	Prion diseases20	8.8	IL1A, IL6, IL1B
4	Cytokine Network36	8.7	IL1B, IL1A, IL6
5	Hematopoietic cell lineage20	8.7	IL6, MME, IL1A, IL1B
6	IL-10 Pathway36	8.5	IL1B, IL6, IL1A
7	Rheumatoid arthritis20	8.4	IL6, CCL2, IL1B, IL1A
8	PEDF Induced Signaling36	8.2	IL1A, SOD2, CCL2, IL6, IL1B
9	Transcription_Role of VDR in regulation of genes involved in osteoporosis41	8.1	VDR, AR, IL6, IL1A, IL1B, CA2
10	Transcription Role of VDR in regulation of genes involved in osteoporosis10	8.1	CA2, IL1A, IL6, AR, VDR, IL1B

Compounds related to urolithiasis according to GeneDecks:

(show top 50)    (show all 229)

id	Compound	Score	Top Affiliating Genes
1	hyaluronic acid32 18	11.5	F2
2	oxalate32	10.1	UMOD, SLC26A1, AGXT, SPP1, NAGLU
3	phosphorus32	9.9	VDR, SPP1, SLC34A1, CASR, NAGLU
4	citrate32	9.7	UMOD, CA2, SOD2, NAGLU, VDR, MME
5	allopurinol32 9 9	11.7	SOD2, NQO1, APRT, XDH, HPRT1, UMOD
6	calcium oxalate32	9.7	GGCX, AGXT, F2, AMBP, APRT, UMOD
7	aprotinin32 9 9	11.5	NAGLU, IL1A, AMBP, F2, PLAU
8	h2o232	9.4	XDH, NQO1, APRT, IL1RN, NAGLU, MME
9	oxygen32 18	10.3	CA2, GGCX, NAGLU, CKB, NQO1, TTF2
10	5 aminosalicylic acid32	9.2	CCL2, NAGLU, XDH, IL1B, AMBP, NQO1
11	vitamin a32 9 18 9	12.0	NAGLU, VDR, MME, HPRT1, ALB, AMBP
12	uric acid32 18	9.9	NAGLU, HPRT1, UMOD, APRT, PRPS1, AMBP
13	epinephrine32 9 18 9	11.9	NPPA, IL1RN, PLAU, IL1A, CA2, F2
14	pge232	8.8	AR, IL1A, MME, IL1RN, CASR, CA2
15	pdtc32	8.8	SOD2, CCL2, IL6, IL1A, XDH
16	ascorbic acid32 18	9.7	VDR, AR, IL1A, HPRT1, SPP1, NQO1
17	aspartate32	8.7	SLC9A3R1, SOD2, AGXT, PLAU, NQO1, CA2
18	calcitriol32 42 9 18 9	12.6	SLC34A1, SOD2, PLAU, SPP1, CA2, CASR
19	calcium32 9 18 9	11.5	NAGLU, GGCX, CASR, SLC34A1, TTF2, AGXT
20	testosterone32 9 18 9	11.4	IL1A, MME, VDR, AR, IL1RN, HPRT1
21	sodium32 18	9.3	TTF2, NAGLU, CASR, SLC34A1, SLC9A3R1, NPPA
22	heparin32 9 18 9	11.3	SOD2, IL1RN, UMOD, F2, ALB, TTF2
23	pentoxifylline32 9 9	10.3	IL1RN, IL6, AMBP, IL1A, NAGLU, IL1B
24	ribonucleic acid32	8.0	SPP1, SOX9, PLAU, IL1A, MME, IL1B
25	il 1032	8.0	IL6, IL1RN, IL1A, IL1B, CCL2, VDR
26	sodium dodecylsulfate32	7.9	NPPA, PLAU, CA2, AR, ALB, AMBP
27	glutamine32	7.8	SOD2, SOX9, VDR, AR, IL1A, CCL2
28	estrogen32	7.5	ESR1, CA2, CASR, F2, IL1RN, VDR
29	fibrinogen32	7.5	PLAU, TTF2, IL1RN, IL6, CCL2, ALB
30	cyclosporin a32 42	8.3	SOD2, TTF2, SPP1, CASR, F2, NAGLU
31	curcumin32	7.2	CCL2, SOD2, IL6, NQO1, SPP1, HPRT1
32	indomethacin32 9 9	9.2	ALB, IL1RN, IL6, PLAU, SOD2, SPP1
33	arginine32	7.1	NPPA, IL1A, CCL2, MME, XDH, CA2
34	methotrexate32 34 42 9 9	10.9	ESR1, NQO1, SOD2, F2, IL6, IL1RN
35	lactate32	6.9	MME, XDH, CKM, CKB, NAGLU, IL1RN
36	lipid32	6.6	IL1RN, MME, XDH, CKM, NAGLU, ALB
37	genistein32 9 18 9	9.6	SOD2, VDR, AR, IL1A, IL1B, IL6
38	nitric oxide32 9 18 9	9.5	TTF2, SLC9A3R1, NAGLU, CKM, XDH, MME
39	alanine32	6.5	AGXT, SLC9A3R1, PLAU, NQO1, SPP1, CA2
40	serine32	6.4	SPP1, IL1RN, IL1A, CASR, AR, MME
41	dexamethasone32 42 34 9 9	10.3	VDR, IL1RN, SOX9, IL6, CCL2, HPRT1
42	actinomycin d32	6.2	SOD2, PLAU, SPP1, ESR1, CASR, CCL2
43	vitamin d32	6.1	TTF2, CCL2, SPP1, ESR1, CASR, ALB
44	cycloheximide32	5.8	IL1RN, IL1B, IL1A, AR, MME, CKB
45	retinoic acid32 42 18	7.8	ESR1, SOX9, PLAU, IL1A, AR, IL1B
46	vegf32	5.7	SOX9, CCL2, MME, AR, IL1A, IL1B
47	glutamate32	INF	CASR, MME, VDR, CKM, GGCX, HPRT1
48	cysteine32	INF	ALB, CASR, NQO1, PLAU, TTF2,
49	n acetylcysteine32	INF	AR, F2, PLAU, , NQO1, NAGLU
50	creatinine32	INF	AMBP, CCL2, APRT, IL1RN, IL1A, CKM

Cellular components related to urolithiasis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:005576	6.4	NPPA, IL1A, IL1B, IL6, CCL2, AMBP
2	extracellular space	GO:005615	6.1	PLAU, IL1A, IL1B, IL1RN, IL6, CCL2

Biological processes related to urolithiasis according to GeneDecks:

(show all 19)

id	Name	GO ID	Score	Top Affiliating Genes
1	glyoxylate catabolic process	GO:009436	10.4	HOGA1, AGXT
2	purine ribonucleoside salvage	GO:006166	10.2	APRT, HPRT1
3	purine nucleobase metabolic process	GO:006144	10.1	XDH, APRT, HPRT1, PRPS1
4	lactation	GO:007595	10.1	VDR, XDH, APRT
5	chronic inflammatory response to antigenic stimulus	GO:002439	9.9	IL1B, IL1RN
6	fever generation	GO:001660	9.9	IL1A, IL1B
7	response to ozone	GO:010193	9.6	IL1A, IL1B
8	protein kinase B signaling cascade	GO:043491	9.6	IL1B, CCL2, SOX9
9	neutrophil chemotaxis	GO:030593	9.5	SPP1, CCL2, IL1B
10	response to organic nitrogen	GO:010243	9.5	IL1B, IL1A, IL1RN
11	regulation of vascular endothelial growth factor production	GO:010574	9.4	CCL2, IL6
12	response to gamma radiation	GO:010332	9.4	IL1A, IL1B, CCL2
13	acute-phase response	GO:006953	8.9	F2, IL6, IL1RN
14	positive regulation of interleukin-6 production	GO:032755	8.9	IL1B, IL6, IL1A
15	response to glucocorticoid stimulus	GO:051384	8.6	AGXT, IL1B, CCL2, IL6, IL1RN
16	negative regulation of cell proliferation	GO:008285	8.4	SLC9A3R1, SOD2, VDR, UMOD, IL1A, IL1B
17	negative regulation of apoptotic process	GO:043066	8.3	IL1RN, IL6, ALB, SOD2, AR, SOX9
18	positive regulation of transcription from RNA polymerase II promoter	GO:045944	7.1	SOX9, ESR1, IL6, IL1B, AR, VDR
19	small molecule metabolic process	GO:044281	INF	ALB, AGXT, NQO1, HPRT1, CA2, NAGLU

Molecular functions related to urolithiasis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	creatine kinase activity	GO:004111	10.2	CKM, CKB
2	interleukin-1 receptor binding	GO:005149	9.4	IL1RN, IL1B, IL1A
3	beta-catenin binding	GO:008013	8.9	SLC9A3R1, SOX9, ESR1, AR
4	receptor binding	GO:005102	8.3	SLC9A3R1, NPPA, AGXT, F2, CCL2, AR